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Pesquisa : D12.776.395.550.200.200.500.500 [Categoria DeCS]
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[PMID]:29301743
[Au] Autor:Dowlatshahi EA; Diercks G; van Doorn M
[Ad] Endereço:Erasmus Medical Centre, Rotterdam, Netherlands emmilia.dowlat@gmail.com.
[Ti] Título:Blisters in disguise.
[So] Source:BMJ;360:j5364, 2018 01 04.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Vesícula/imunologia
Vesícula/patologia
Pênfigo/imunologia
Pênfigo/patologia
Pele/patologia
[Mh] Termos MeSH secundário: Corticosteroides/administração & dosagem
Corticosteroides/uso terapêutico
Idoso
Vesícula/tratamento farmacológico
Vesícula/epidemiologia
Desmogleínas/imunologia
Diagnóstico Diferencial
Ensaio de Imunoadsorção Enzimática/métodos
Técnica Direta de Fluorescência para Anticorpo/métodos
Seres Humanos
Fatores Imunológicos/administração & dosagem
Fatores Imunológicos/uso terapêutico
Imunossupressores/administração & dosagem
Imunossupressores/uso terapêutico
Incidência
Masculino
Pênfigo/tratamento farmacológico
Pênfigo/epidemiologia
Rituximab/administração & dosagem
Rituximab/uso terapêutico
Pele/imunologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Desmogleins); 0 (Immunologic Factors); 0 (Immunosuppressive Agents); 4F4X42SYQ6 (Rituximab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5364


  2 / 420 MEDLINE  
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[PMID]:27501241
[Au] Autor:Sawant S; Dongre H; Singh AK; Joshi S; Costea DE; Mahadik S; Ahire C; Makani V; Dange P; Sharma S; Chaukar D; Vaidya M
[Ad] Endereço:Vaidya Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra, India.
[Ti] Título:Establishment of 3D Co-Culture Models from Different Stages of Human Tongue Tumorigenesis: Utility in Understanding Neoplastic Progression.
[So] Source:PLoS One;11(8):e0160615, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To study multistep tumorigenesis process, there is a need of in-vitro 3D model simulating in-vivo tissue. Present study aimed to reconstitute in-vitro tissue models comprising various stages of neoplastic progression of tongue tumorigenesis and to evaluate the utility of these models to investigate the role of stromal fibroblasts in maintenance of desmosomal anchoring junctions using transmission electron microscopy. We reconstituted in-vitro models representing normal, dysplastic, and malignant tissues by seeding primary keratinocytes on either fibroblast embedded in collagen matrix or plain collagen matrix in growth factor-free medium. The findings of histomorphometry, immunohistochemistry, and electron microscopy analyses of the three types of 3D cultures showed that the stratified growth, cell proliferation, and differentiation were comparable between co-cultures and their respective native tissues; however, they largely differed in cultures grown without fibroblasts. The immunostaining intensity of proteins, viz., desmoplakin, desmoglein, and plakoglobin, was reduced as the disease stage increased in all co-cultures as observed in respective native tissues. Desmosome-like structures were identified using immunogold labeling in these cultures. Moreover, electron microscopic observations revealed that the desmosome number and their length were significantly reduced and intercellular spaces were increased in cultures grown without fibroblasts when compared with their co-culture counterparts. Our results showed that the major steps of tongue tumorigenesis can be reproduced in-vitro. Stromal fibroblasts play a role in regulation of epithelial thickness, cell proliferation, differentiation, and maintenance of desmosomalanchoring junctions in in-vitro grown tissues. The reconstituted co-culture models could help to answer various biological questions especially related to tongue tumorigenesis.
[Mh] Termos MeSH primário: Técnicas de Cocultura/métodos
Neoplasias da Língua/patologia
[Mh] Termos MeSH secundário: Diferenciação Celular
Proliferação Celular
Transformação Celular Neoplásica
Desmogleínas/metabolismo
Desmoplaquinas/metabolismo
Desmossomos/metabolismo
Desmossomos/ultraestrutura
Fibroblastos/patologia
Seres Humanos
Queratinócitos/patologia
Língua/patologia
gama Catenina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DSP protein, human); 0 (Desmogleins); 0 (Desmoplakins); 0 (JUP protein, human); 0 (gamma Catenin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0160615


  3 / 420 MEDLINE  
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[PMID]:27298358
[Au] Autor:Harrison OJ; Brasch J; Lasso G; Katsamba PS; Ahlsen G; Honig B; Shapiro L
[Ad] Endereço:Department of Systems Biology, Columbia University, New York, NY 10032; Howard Hughes Medical Institute, Columbia University, New York, NY 10032;
[Ti] Título:Structural basis of adhesive binding by desmocollins and desmogleins.
[So] Source:Proc Natl Acad Sci U S A;113(26):7160-5, 2016 06 28.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues. Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and desmocollins (Dscs), but the nature of trans-cellular interactions between these specialized cadherins is unclear. Here, using solution biophysics and coated-bead aggregation experiments, we demonstrate family-wise heterophilic specificity: All Dsgs form adhesive dimers with all Dscs, with affinities characteristic of each Dsg:Dsc pair. Crystal structures of ectodomains from Dsg2 and Dsg3 and from Dsc1 and Dsc2 show binding through a strand-swap mechanism similar to that of homophilic classical cadherins. However, conserved charged amino acids inhibit Dsg:Dsg and Dsc:Dsc interactions by same-charge repulsion and promote heterophilic Dsg:Dsc interactions through opposite-charge attraction. These findings show that Dsg:Dsc heterodimers represent the fundamental adhesive unit of desmosomes and provide a structural framework for understanding desmosome assembly.
[Mh] Termos MeSH primário: Adesivos/química
Desmocolinas/química
Desmogleínas/química
[Mh] Termos MeSH secundário: Adesivos/metabolismo
Desmocolinas/metabolismo
Desmogleínas/metabolismo
Dimerização
Seres Humanos
Cinética
Conformação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adhesives); 0 (Desmocollins); 0 (Desmogleins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1606272113


  4 / 420 MEDLINE  
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[PMID]:26985930
[Au] Autor:E GX; Zhao YJ; Ma YH; Cao GL; He JN; Na RS; Zhao ZQ; Jiang CD; Zhang JH; Arlvd S; Chen LP; Qiu XY; Hu W; Huang YF
[Ad] Endereço:Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
[Ti] Título:Desmoglein 4 diversity and correlation analysis with coat color in goat.
[So] Source:Genet Mol Res;15(1):15017814, 2016 Mar 04.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Desmoglein 4 (DSG4) has an important role in the development of wool traits in domestic animals. The full-length DSG4 gene, which contains 3918 bp, a complete open-reading-frame, and encodes a 1040-amino acid protein, was amplified from Liaoning cashmere goat. The sequence was compared with that of DSG4 from other animals and the results show that the DSG4 coding region is consistent with interspecies conservation. Thirteen single-nucleotide polymorphisms (SNPs) were identified in a highly variable region of DSG4, and one SNP (M-1, G>T) was significantly correlated with white and black coat color in goat. Haplotype distribution of the highly variable region of DSG4 was assessed in 179 individuals from seven goat breeds to investigate its association with coat color and its differentiation among populations. However, the lack of a signature result indicates DGS4 haplotypes related with the color of goat coat.
[Mh] Termos MeSH primário: Desmogleínas/genética
Cabras/metabolismo
Cor de Cabelo/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Animais
Cabras/genética
Haplótipos
Filogenia
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Desmogleins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160318
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15017814


  5 / 420 MEDLINE  
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[PMID]:26831096
[Au] Autor:Sajda T; Hazelton J; Patel M; Seiffert-Sinha K; Steinman L; Robinson W; Haab BB; Sinha AA
[Ad] Endereço:Department of Dermatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203;
[Ti] Título:Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus.
[So] Source:Proc Natl Acad Sci U S A;113(7):1859-64, 2016 Feb 16.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patients with pemphigus vulgaris (PV) harbor antibodies reactive against self-antigens expressed at the surface of keratinocytes, primarily desmoglein (Dsg) 3 and, to a lesser extent, Dsg1. Conventionally, only antibodies targeting these molecules have been thought to contribute to disease pathogenesis. This notion has been challenged by a growing pool of evidence that suggests that antibodies toward additional targets may play a role in disease. The aims of this study were to (i) establish high-throughput protein microarray technology as a method to investigate traditional and putative autoantibodies (autoAbs) in PV and (ii) use multiplexed protein array technology to define the scope and specificity of the autoAb response in PV. Our analysis demonstrated significant IgG reactivity in patients with PV toward the muscarinic acetylcholine receptor subtypes 3, 4, and 5 as well as thyroid peroxidase. Furthermore, we found that healthy first- and second-degree relatives of patients with PV express autoAbs toward desmoglein and non-Dsg targets. Our analysis also identified genetic elements, particularly HLA, as key drivers of autoAb expression. Finally, we show that patients with PV exhibit significantly reduced IgM reactivity toward disease-associated antigens relative to controls. The use of protein microarrays to profile the autoAb response in PV advanced the current understanding of disease and provided insight into the complex relationship between genetics and disease development.
[Mh] Termos MeSH primário: Autoantígenos/imunologia
Desmogleínas/imunologia
Antígenos HLA/imunologia
Pênfigo/imunologia
[Mh] Termos MeSH secundário: Especificidade de Anticorpos
Estudos de Casos e Controles
Seres Humanos
Análise Serial de Proteínas
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Autoantigens); 0 (Desmogleins); 0 (HLA Antigens)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160203
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1525448113


  6 / 420 MEDLINE  
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[PMID]:26798993
[Au] Autor:Giurdanella F; Diercks GF; Jonkman MF; Pas HH
[Ad] Endereço:Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, P.O. Box 30 001, 9700 RB, Groningen, the Netherlands.
[Ti] Título:Laboratory diagnosis of pemphigus: direct immunofluorescence remains the gold standard.
[So] Source:Br J Dermatol;175(1):185-6, 2016 Jul.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Técnicas de Laboratório Clínico/métodos
Pênfigo/diagnóstico
[Mh] Termos MeSH secundário: Anticorpos/metabolismo
Desmogleínas/imunologia
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Padrões de Referência
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Antibodies); 0 (Desmogleins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160123
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.14408


  7 / 420 MEDLINE  
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[PMID]:26790650
[Au] Autor:Hammers CM; Stanley JR
[Ad] Endereço:Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, Bldg 10, Lübeck, D-23562, Germany.
[Ti] Título:Patients with pemphigus foliaceus may retain antibody reactivity against calcium-stabilized, distal desmoglein 1 domains in remission.
[So] Source:Br J Dermatol;174(1):17-8, 2016 Jan.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Desmogleína 1/imunologia
Pênfigo/imunologia
[Mh] Termos MeSH secundário: Autoanticorpos/imunologia
Caderinas/imunologia
Cálcio
Desmogleína 3
Desmogleínas
Seres Humanos
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Cadherins); 0 (Desmoglein 1); 0 (Desmoglein 3); 0 (Desmogleins); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160121
[Lr] Data última revisão:
160121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160122
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.14262


  8 / 420 MEDLINE  
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[PMID]:26597100
[Au] Autor:Di Zenzo G; Amber KT; Sayar BS; Müller EJ; Borradori L
[Ad] Endereço:Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.
[Ti] Título:Immune response in pemphigus and beyond: progresses and emerging concepts.
[So] Source:Semin Immunopathol;38(1):57-74, 2016 Jan.
[Is] ISSN:1863-2300
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1. These two desmosomal cadherins, typifying stratified epithelia, are components of cell adhesion complexes called desmosomes and represent extra-desmosomal adhesion receptors. We herein review the advances in our understanding of the immune response underlying pemphigus, including human leucocyte antigen (HLA) class II-associated genetic susceptibility, characteristics of pathogenic anti-Dsg antibodies, antigenic mapping studies as well as findings about Dsg-specific B and T cells. The pathogenicity of anti-Dsg autoantibodies has been convincingly demonstrated. Disease activity and clinical phenotype correlate with anti-Dsg antibody titers and profile while passive transfer of anti-Dsg IgG from pemphigus patients' results in pemphigus-like lesions in neonatal and adult mice. Finally, adoptive transfer of splenocytes from Dsg3-knockout mice immunized with murine Dsg3 into immunodeficient mice phenotypically recapitulates PV. Although the exact pathogenic mechanisms leading to blister formation have not been fully elucidated, intracellular signaling following antibody binding has been found to be necessary for inducing cell-cell dissociation, at least for PV. These new insights not only highlight the key role of Dsgs in maintenance of tissue homeostasis but are expected to progressively change pemphigus management, paving the way for novel targeted immunologic and pharmacologic therapies.
[Mh] Termos MeSH primário: Pênfigo/diagnóstico
Pênfigo/etiologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/imunologia
Autoanticorpos/genética
Autoanticorpos/imunologia
Autoantígenos/imunologia
Desmogleínas/imunologia
Progressão da Doença
Epitopos/imunologia
Predisposição Genética para Doença
Seres Humanos
Soros Imunes/imunologia
Idiotipos de Imunoglobulinas/genética
Idiotipos de Imunoglobulinas/imunologia
Mutação
Especificidade de Órgãos/imunologia
Pênfigo/epidemiologia
Pênfigo/terapia
Transdução de Sinais
Subpopulações de Linfócitos T/imunologia
Subpopulações de Linfócitos T/metabolismo
Pesquisa Médica Translacional
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Autoantibodies); 0 (Autoantigens); 0 (Desmogleins); 0 (Epitopes); 0 (Immune Sera); 0 (Immunoglobulin Idiotypes)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151125
[St] Status:MEDLINE
[do] DOI:10.1007/s00281-015-0541-1


  9 / 420 MEDLINE  
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[PMID]:26566588
[Au] Autor:Toosi S; Collins JW; Lohse CM; Wolz MM; Wieland CN; Camilleri MJ; Bruce AJ; McEvoy MT; Lehman JS
[Ad] Endereço:Mayo Clinic, Rochester, MN, USA.
[Ti] Título:Clinicopathologic features of IgG/IgA pemphigus in comparison with classic (IgG) and IgA pemphigus.
[So] Source:Int J Dermatol;55(4):e184-90, 2016 Apr.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The pemphigus group is characterized by the presence of circulating immunoglobulins against desmosomes. IgG/IgA pemphigus is defined by the presence of IgG and IgA cell surface deposits upon direct immunofluorescence (DIF) and/or circulating IgG and IgA autoantibodies upon indirect immunofluorescence. Previous reports of patients with IgG/IgA pemphigus are sparse. Whether IgG/IgA pemphigus is best classified as a subtype of IgG (classic) pemphigus or IgA pemphigus, or as a distinct entity, has yet to be determined. OBJECTIVES: We compared the features of patients with IgG/IgA pemphigus to those of IgG pemphigus and IgA pemphigus. METHODS: Retrospective clinicopathologic study of patients with IgG, IgG/IgA, and IgA pemphigus evaluated at our clinic (1993-2013). RESULTS: We included 26, 13, and seven patients with IgG, IgG/IgA, and IgA pemphigus, respectively. Patients with IgG/IgA pemphigus did not differ significantly from patients with IgG pemphigus in terms of clinical and microscopic features, DIF findings, anti-desmoglein antibody values, and treatments required. However, patients with IgG/IgA pemphigus were significantly different from patients with IgA pemphigus regarding intertriginous distribution (P = 0.038) and pustular lesions (P < 0.001), acantholysis (P = 0.043), and presence of intercellular C3 deposits on DIF (P < 0.001). CONCLUSION: Comparative clinicopathologic data imply that IgG/IgA pemphigus may best be regarded as a variant of IgG pemphigus and distinct from IgA pemphigus.
[Mh] Termos MeSH primário: Imunoglobulina A/análise
Imunoglobulina G/análise
Pênfigo/metabolismo
Pênfigo/patologia
[Mh] Termos MeSH secundário: Acantólise/etiologia
Adulto
Idoso
Autoanticorpos/sangue
Complemento C3/análise
Desmogleínas/imunologia
Feminino
Técnica Direta de Fluorescência para Anticorpo
Seres Humanos
Masculino
Meia-Idade
Pênfigo/complicações
Pênfigo/imunologia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Complement C3); 0 (Desmogleins); 0 (Immunoglobulin A); 0 (Immunoglobulin G)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151115
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.13025


  10 / 420 MEDLINE  
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[PMID]:26726323
[Au] Autor:Hashimoto T; Ishii N; Demitsu T
[Ti] Título:Response to the letter to the editor by Muro et al.
[So] Source:Acta Derm Venereol;95(7):873-4, 2015 Sep.
[Is] ISSN:1651-2057
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Mh] Termos MeSH primário: Autoanticorpos/sangue
Doença de Bowen/imunologia
Desmogleínas/imunologia
Neoplasias Cutâneas/imunologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Desmogleins)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151231
[Lr] Data última revisão:
151231
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160105
[St] Status:MEDLINE



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