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[PMID]: | 29275565 |
[Au] Autor: | Li P; Li WL; Qi JX |
[Ad] Endereço: | Department of Head Neck and Thyroid, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008, China. |
[Ti] Título: | [Expression of integrin αvß3, CXC chemokine receptor 4 and CXC chemokine receptor 7 and their relationship with lymph node metastasis in squamous cell carcinoma of head and neck]. |
[So] Source: | Zhonghua Kou Qiang Yi Xue Za Zhi;52(12):723-729, 2017 Dec 09. | [Is] ISSN: | 1002-0098 |
[Cp] País de publicação: | China |
[La] Idioma: | chi |
[Ab] Resumo: | To investigate the expression of integrin αvß3, CXC chemokine receptor (CXCR)4 and CXCR7 and their relationship with lymph node metastasis in squamous cell carcinoma of head and neck (SCCHN). The expression of integrin αvß3, CXCR4 and CXCR7 was detected by immunohistochemistry SABC in 92 cases of primary SCCHN, metastatic lymph node, normal oral mucosa tissues and normal lymph nodes. The positive rate of the expression of integrin αvß3, CXCR4 and CXCR7 was 75% (69/92), 81%(75/92) and 76%(70/92), respectively in primary SCCHN, and was 82%(75/92), 76%(70/92) and 65%(60/92), respectively in metastatic lymph node. The expression of integrin αvß3 and CXCR4 in primary SCCHN ( 0.813, 0.05) and lymph node metastasis ( 0.541, 0.05) was positively correlated. Integrin αvß3 and CXCR7 expression in primary SCCHN ( 0.683, 0.05) and lymph node metastasis ( 0.708, 0.05) was positively correlated. CXCR4 and CXCR7 expression in primary SCCHN ( 0.644, 0.05) and lymph node metastasis ( 0.707, 0.05) had a positive correlation. The expression level was associated with tumor size ( 0.040, 0.001, 0.009), lymph node metastasis ( 0.001, 0.000, 0.000) and surrounding tissue invasion ( 0.046, 0.002, 0.001), but not related to age ( 0.097, 0.274, 0.162), gender ( 0.103, 0.309, 0.187). The overexpression of integrin αvß3, CXCR4 and CXCR7 in primary head and neck squamous carcinoma and metastatic lymph nodes was related to lymph node metastasis. The co-expression of integrin αvß3, CXCR4 and CXCR7 may play a synergistic role in lymphatic metastasis of SCCHN. |
[Mh] Termos MeSH primário: |
Carcinoma de Células Escamosas/metabolismo Carcinoma de Células Escamosas/secundário Neoplasias de Cabeça e Pescoço/metabolismo Neoplasias de Cabeça e Pescoço/patologia Integrina alfaVbeta3/metabolismo Receptores CXCR4/metabolismo Receptores CXCR/metabolismo
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[Mh] Termos MeSH secundário: |
Seres Humanos Imuno-Histoquímica Metástase Linfática RNA Mensageiro/metabolismo
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (CXCR4 protein, human); 0 (CXCR7 protein, human); 0 (Integrin alphaVbeta3); 0 (RNA, Messenger); 0 (Receptors, CXCR); 0 (Receptors, CXCR4) |
[Em] Mês de entrada: | 1802 |
[Cu] Atualização por classe: | 180209 |
[Lr] Data última revisão:
| 180209 |
[Sb] Subgrupo de revista: | D; IM |
[Da] Data de entrada para processamento: | 171226 |
[St] Status: | MEDLINE |
[do] DOI: | 10.3760/cma.j.issn.1002-0098.2017.12.003 |
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