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[PMID]:28358790
[Au] Autor:Wu Q; Nie J; Wu FX; Zou XL; Chen FY
[Ad] Endereço:Department of Pediatrics, People's Hospital of China Three Gorges University, The 1st People's Hospital of Yichang, Yichang, Hubei, China (mainland).
[Ti] Título:Prognostic Value of High-Sensitivity C-Reactive Protein, Procalcitonin and Pancreatic Stone Protein in Pediatric Sepsis.
[So] Source:Med Sci Monit;23:1533-1539, 2017 Mar 30.
[Is] ISSN:1643-3750
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND To investigate the prognostic value of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), and pancreatic stone protein (PSP) in children with sepsis. MATERIAL AND METHODS A total of 214 patients with sepsis during hospitalization were enrolled. Serum levels of PCT, hs-CRP, and PSP were measured on day 1 of hospitalization and the survival rates of children were recorded after a follow-up of 28 days. Pearson's correlation analysis was conducted to test the association of PCT, hs-CRP, and PSP with pediatric critical illness score (PCIS). Logistic regression models were used to analyze the risk factors contributing to patients' death. The AUC was used to determine the value of PCT, hs-CRP, and PSP in the prognosis of patients with sepsis. RESULTS The expression of PCT, hs-CRP, and PSP in the dying patients was higher than in the surviving patients (p<0.001). Pearson's correlation analysis showed that serum PCT, hs-CRP, and PSP levels were negatively correlated with PCIS (p<0.001). Multivariate logistic regression revealed that PCT, hs-CRP, and PSP were independent risk factors for the prognosis of patients with sepsis (p<0.001). ROC analysis showed the AUC values of PCT, hs-CRP, and PSP were 0.83 (95% CI, 0.77-0.88), 0.76 (95% CI, 0.70-0.82), and 0.73 (95% CI, 0.67-0.79), respectively. The combined AUC value of PCT, hs-CRP, and PSP, was 0.92 (95% CI, 0.87-0.95), which was significantly increased compared with PCT, hs-CRP, or PSP (p<0.001). CONCLUSIONS The combination of serum PCT, hs-CRP, and PSP represents a promising biomarker of risk, and is a useful clinical tool for risk stratification of children with sepsis.
[Mh] Termos MeSH primário: Proteína C-Reativa/metabolismo
Calcitonina/sangue
Litostatina/sangue
Sepse/sangue
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Modelos Logísticos
Masculino
Análise Multivariada
Prognóstico
Curva ROC
Fatores de Risco
Sepse/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lithostathine); 9007-12-9 (Calcitonin); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


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[PMID]:28209239
[Au] Autor:Geng J; Fan J; Wang Q; Zhang XP; Kang L; Li QY; Xu YF; Peng B; Zheng JH; Yao XD
[Ad] Endereço:Department of Urology, Tenth People's Hospital, Tongji University, Shanghai, 200072, China. Electronic address: gengjiangsn@sina.com.
[Ti] Título:Decreased REG1α expression suppresses growth, invasion and angiogenesis of bladder cancer.
[So] Source:Eur J Surg Oncol;43(4):837-846, 2017 Apr.
[Is] ISSN:1532-2157
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous study has indicated association between REG1α and bladder cancer. The aim of this study was to investigate the role of Regenerating gene I alpha (REG1α) in bladder cancer. METHODS: The role of REG1α in bladder cancer cell proliferation, migration and VEGF-induced angiogenesis was explored in vitro and in vivo. Immunohistochemistry (IHC) analysis was assessed to determine the expression of REG1α in ten paired bladder cancer and adjacent non-cancerous tissues, and in 296 bladder cancer samples. RESULTS: Down-regulation of REG1α expression significantly reduced the proliferation, migration, invasion and VEGF-induced angiogenesis in vitro and the growth of xenograft tumors in vivo. VEGF expression in bladder cancer is associated with REG1α expression and recurrence. REG1α was overexpressed in bladder cancer tissues compared with adjacent normal samples. Patients with elevated REG1α exhibited shorter recurrence times and poor survival. CONCLUSION: Downregulation of REG1α expression can reduce tumor growth, migration, invasion and angiogenesis. Our study demonstrates that REG1α can be used as a marker of recurrence and prognosis in bladder cancer. Therefore, REG1α targeting in bladder cancer patients represents a promising therapeutic strategy.
[Mh] Termos MeSH primário: Carcinoma de Células de Transição/metabolismo
Regulação Neoplásica da Expressão Gênica
Litostatina/metabolismo
Neovascularização Patológica/metabolismo
Neoplasias da Bexiga Urinária/metabolismo
Fator A de Crescimento do Endotélio Vascular/secreção
[Mh] Termos MeSH secundário: Animais
Western Blotting
Carcinoma de Células de Transição/patologia
Linhagem Celular Tumoral
Movimento Celular
Proliferação Celular
Regulação para Baixo
Seres Humanos
Imuno-Histoquímica
Técnicas In Vitro
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Invasividade Neoplásica
Transplante de Neoplasias
Interferência de RNA
Distribuição Aleatória
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Neoplasias da Bexiga Urinária/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lithostathine); 0 (REG1A protein, human); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:28155994
[Au] Autor:García de Guadiana-Romualdo L; Berger M; Jiménez-Santos E; Rebollo-Acebes S; Jiménez-Sánchez R; Esteban-Torrella P; Hernando-Holgado A; Ortín-Freire A; Albaladejo-Otón MD
[Ad] Endereço:Clinical Chemistry Laboratory, Santa Lucía Hospital, Cartagena, Spain.
[Ti] Título:Pancreatic stone protein and soluble CD25 for infection and sepsis in an emergency department.
[So] Source:Eur J Clin Invest;47(4):297-304, 2017 Apr.
[Is] ISSN:1365-2362
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Infection is a common problem in emergency departments (EDs) and is associated with high mortality, morbidity and costs. Identifying infection in ED patients can be challenging. Biomarkers can facilitate its diagnosis, enabling an early management and improving outcomes. In the critical care setting, two emerging biomarkers, pancreatic stone protein (PSP) and soluble CD25 (sCD25), have demonstrated to be useful for diagnosis of sepsis. We aimed to assess the diagnostic value of these biomarkers, in comparison with procalcitonin (PCT), for infection and sepsis in an ED population with suspected infection. MATERIALS AND METHODS: Through a prospective, observational study, we investigated the utility of serum PCT, PSP and sCD25 levels, measured on admission, for diagnosis of infection and sepsis, defined according to the recently updated for sepsis (Sepsis-3), in patients presenting to the ED for suspected infection. Diagnostic accuracy was evaluated by using receiver operating characteristic curves (ROC) analysis. RESULTS: Of the 152 patients enrolled in this study, 129 had a final diagnosis of infection, including 82 with noncomplicated infection and 47 with sepsis. Median PCT, PSP and sCD25 levels were significantly higher in patients with infection and sepsis. The ROC curve analysis revealed a similar diagnostic accuracy for infection (ROC area under the curve (AUC) PCT: 0·904; sCD25: 0·869 and PSP: 0·839) and for sepsis (ROC AUC: PCT: 0·820; sCD25: 0·835 and PSP: 0·872). CONCLUSIONS: Pancreatic stone protein and sCD25 perform well as infection and sepsis biomarkers, with a similar performance than PCT, in ED patients with suspected infection. Further larger studies investigating use of PSP and sCD25 are needed.
[Mh] Termos MeSH primário: Infecção/diagnóstico
Subunidade alfa de Receptor de Interleucina-2/metabolismo
Litostatina/metabolismo
Sepse/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/metabolismo
Calcitonina/metabolismo
Tomada de Decisão Clínica
Serviço Hospitalar de Emergência
Tratamento de Emergência
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Curva ROC
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (IL2RA protein, human); 0 (Interleukin-2 Receptor alpha Subunit); 0 (Lithostathine); 9007-12-9 (Calcitonin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1111/eci.12732


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[PMID]:27846243
[Au] Autor:Lennard KS; Goosen RW; Blackburn JM
[Ad] Endereço:Institute of Infectious Disease and Molecular Medicine & Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.
[Ti] Título:Bacterially-Associated Transcriptional Remodelling in a Distinct Genomic Subtype of Colorectal Cancer Provides a Plausible Molecular Basis for Disease Development.
[So] Source:PLoS One;11(11):e0166282, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The relevance of specific microbial colonisation to colorectal cancer (CRC) disease pathogenesis is increasingly recognised, but our understanding of possible underlying molecular mechanisms that may link colonisation to disease in vivo remains limited. Here, we investigate the relationships between the most commonly studied CRC-associated bacteria (Enterotoxigenic Bacteroides fragilis, pks+ Escherichia coli, Fusobacterium spp., afaC+ E. coli, Enterococcus faecalis & Enteropathogenic E. coli) and altered transcriptomic and methylation profiles of CRC patients, in order to gain insight into the potential contribution of these bacteria in the aetiopathogenesis of CRC. We show that colonisation by E. faecalis and high levels of Fusobacterium is associated with a specific transcriptomic subtype of CRC that is characterised by CpG island methylation, microsatellite instability and a significant increase in inflammatory and DNA damage pathways. Analysis of the significant, bacterially-associated changes in host gene expression, both at the level of individual genes as well as pathways, revealed a transcriptional remodeling that provides a plausible mechanistic link between specific bacterial colonisation and colorectal cancer disease development and progression in this subtype; these included upregulation of REG3A, REG1A and REG1P in the case of high-level colonization by Fusobacterium, and CXCL10 and BMI1 in the case of colonisation by E. faecalis. The enrichment of both E. faecalis and Fusobacterium in this CRC subtype suggests that polymicrobial colonisation of the colonic epithelium may well be an important aspect of colonic tumourigenesis.
[Mh] Termos MeSH primário: Neoplasias Colorretais/genética
Neoplasias Colorretais/microbiologia
Metilação de DNA/genética
Transcriptoma/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Antígenos de Neoplasias/biossíntese
Antígenos de Neoplasias/genética
Bacteroides fragilis/patogenicidade
Biomarcadores Tumorais/biossíntese
Biomarcadores Tumorais/genética
Quimiocina CXCL10/biossíntese
Quimiocina CXCL10/genética
Contagem de Colônia Microbiana
Neoplasias Colorretais/patologia
Ilhas de CpG/genética
Enterococcus faecalis/patogenicidade
Escherichia coli Enteropatogênica/patogenicidade
Feminino
Fusobacterium/patogenicidade
Regulação Neoplásica da Expressão Gênica
Genômica
Interações Hospedeiro-Patógeno/genética
Seres Humanos
Mucosa Intestinal/microbiologia
Mucosa Intestinal/patologia
Lectinas Tipo C/biossíntese
Lectinas Tipo C/genética
Litostatina/biossíntese
Litostatina/genética
Masculino
Instabilidade de Microssatélites
Meia-Idade
Proteínas Associadas a Pancreatite
Complexo Repressor Polycomb 1/biossíntese
Complexo Repressor Polycomb 1/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Neoplasm); 0 (BMI1 protein, human); 0 (Biomarkers, Tumor); 0 (CXCL10 protein, human); 0 (Chemokine CXCL10); 0 (Lectins, C-Type); 0 (Lithostathine); 0 (Pancreatitis-Associated Proteins); 0 (REG1A protein, human); 0 (REG3A protein, human); EC 2.3.2.27 (Polycomb Repressive Complex 1)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0166282


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[PMID]:27539087
[Au] Autor:Aboshanif M; Kawasaki Y; Omori Y; Suzuki S; Honda K; Motoyama S; Ishikawa K
[Ad] Endereço:Department of Otorhinolaryngology, Head and Neck Surgery, Akita Graduate School of Medicine, Akita, Japan.
[Ti] Título:Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.
[So] Source:Diagn Pathol;11(1):79, 2016 Aug 18.
[Is] ISSN:1746-1596
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Regenerating gene (REG) family is composed of antiapoptotic factors and growth factors that affect epithelial cells within the digestive system. Regenerating gene-I has been studied in different cancers. However, it has never been studied in head and neck cancer. We investigated the expression of REG-I in head and neck SCC and its relevance to patient survival rates. METHODS: Untreated biopsy specimens of 60 patients with stage IV head and neck SCC were collected, and the expression of REG-I was evaluated using immunohistochemistry. The association between REG-I expression and clinico-pathological features or survival status of the patients was assessed by Chi-square test, Fisher's exact test and Kaplan-Meier method. Cox proportional hazard model was used to identify the independent prognostic factors. RESULTS: Incidence of lymphatic permeation, vascular invasion and pathological lymph nodes was significantly higher in REG-I negative group (p = 0.008, 0.030 and 0.015, respectively). Overall and cancer-free survival rates were significantly higher in REG-I positive group (p = 0.000434 and 1.0847E-8, respectively). Univariate analysis showed that REG-I was an independent prognostic factor for predicting long-term overall survival (p = 0.002), and multivariate analysis showed that REG-I and lymphatic permeation were independent prognostic factors for predicting long-term disease-free survival (p = 0.001 and 0.022, respectively). CONCLUSION: Our results showed for the first time that, REG-I is expressed in head and neck SCC. REG-I expression is associated with a longer survival status. We conclude that, REG-I might be a prognostic marker in head and neck SSC and should be further investigated.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Carcinoma de Células Escamosas/química
Neoplasias de Cabeça e Pescoço/química
Litostatina/análise
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biópsia
Carcinoma de Células Escamosas/mortalidade
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/terapia
Distribuição de Qui-Quadrado
Intervalo Livre de Doença
Feminino
Neoplasias de Cabeça e Pescoço/mortalidade
Neoplasias de Cabeça e Pescoço/patologia
Neoplasias de Cabeça e Pescoço/terapia
Seres Humanos
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Estadiamento de Neoplasias
Valor Preditivo dos Testes
Modelos de Riscos Proporcionais
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Lithostathine); 0 (REG1A protein, human); 0 (REG1B protein, human)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160820
[St] Status:MEDLINE
[do] DOI:10.1186/s13000-016-0526-y


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[PMID]:27329801
[Au] Autor:Bianchi MS; Bianchi S; Hernado-Insúa A; Martinez LM; Lago N; Libertun C; Chasseing NA; Montaner AD; Lux-Lantos VA
[Ad] Endereço:Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina;
[Ti] Título:Proposed mechanisms for oligonucleotide IMT504 induced diabetes reversion in a mouse model of immunodependent diabetes.
[So] Source:Am J Physiol Endocrinol Metab;311(2):E380-95, 2016 Aug 01.
[Is] ISSN:1522-1555
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Type 1 diabetes (T1D) originates from autoimmune ß-cell destruction. IMT504 is an immunomodulatory oligonucleotide that increases mesenchymal stem cell cloning capacity and reverts toxic diabetes in rats. Here, we evaluated long-term (20 doses) and short-term (2-6 doses) effects of IMT504 (20 mg·kg(-1)·day(-1) sc) in an immunodependent diabetes model: multiple low-dose streptozotocin-injected BALB/c mice (40 mg·kg(-1)·day(-1) ip for 5 consecutive days). We determined blood glucose, glucose tolerance, serum insulin, islet morphology, islet infiltration, serum cytokines, progenitor cell markers, immunomodulatory proteins, proliferation, apoptosis, and islet gene expression. IMT504 reduced glycemia, induced ß-cell recovery, and impaired islet infiltration. IMT504 induced early blood glucose decrease and infiltration inhibition, increased ß-cell proliferation and decreased apoptosis, increased islet indoleamine 2,3-dioxygenase (IDO) expression, and increased serum tumor necrosis factor and interleukin-6 (IL-6). IMT504 affected islet gene expression; preproinsulin-2, proglucagon, somatostatin, nestin, regenerating gene-1, and C-X-C motif ligand-1 cytokine (Cxcl1) increased in islets from diabetic mice and were decreased by IMT504. IMT504 downregulated platelet endothelial cell adhesion molecule-1 (Pecam1) in islets from control and diabetic mice, whereas it increased regenerating gene-2 (Reg2) in islets of diabetic mice. The IMT504-induced increase in IL-6 and islet IDO expression and decreased islet Pecam1 and Cxcl1 mRNA expression could participate in keeping leukocyte infiltration at bay, whereas upregulation of Reg2 may mediate ß-cell regeneration. We conclude that IMT504 effectively reversed immunodependent diabetes in mice. Corroboration of these effects in a model of autoimmune diabetes more similar to human T1D could provide promising results for the treatment of this disease.
[Mh] Termos MeSH primário: Glicemia/efeitos dos fármacos
Citocinas/efeitos dos fármacos
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Tipo 1/metabolismo
Células Secretoras de Insulina/efeitos dos fármacos
Oligodesoxirribonucleotídeos/farmacologia
RNA Mensageiro/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Glicemia/metabolismo
Proliferação Celular/efeitos dos fármacos
Quimiocina CXCL1/efeitos dos fármacos
Quimiocina CXCL1/genética
Citocinas/metabolismo
Diabetes Mellitus Experimental/genética
Diabetes Mellitus Tipo 1/genética
Modelos Animais de Doenças
Teste de Tolerância a Glucose
Indolamina-Pirrol 2,3,-Dioxigenase/efeitos dos fármacos
Indolamina-Pirrol 2,3,-Dioxigenase/metabolismo
Insulina/genética
Insulina/metabolismo
Células Secretoras de Insulina/metabolismo
Interleucina-6/metabolismo
Ilhotas Pancreáticas/efeitos dos fármacos
Ilhotas Pancreáticas/metabolismo
Ilhotas Pancreáticas/patologia
Litostatina/efeitos dos fármacos
Litostatina/genética
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Nestina/efeitos dos fármacos
Nestina/genética
Proteínas Associadas a Pancreatite
Molécula-1 de Adesão Celular Endotelial de Plaquetas/efeitos dos fármacos
Molécula-1 de Adesão Celular Endotelial de Plaquetas/genética
Proglucagon/efeitos dos fármacos
Proglucagon/genética
Precursores de Proteínas/efeitos dos fármacos
Precursores de Proteínas/genética
Proteínas/efeitos dos fármacos
Proteínas/genética
RNA Mensageiro/metabolismo
Somatostatina/efeitos dos fármacos
Somatostatina/genética
Células-Tronco/efeitos dos fármacos
Células-Tronco/metabolismo
Transcriptoma/efeitos dos fármacos
Fator de Necrose Tumoral alfa/efeitos dos fármacos
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Chemokine CXCL1); 0 (Cxcl1 protein, mouse); 0 (Cytokines); 0 (IMT504); 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase); 0 (Insulin); 0 (Interleukin-6); 0 (Lithostathine); 0 (Nes protein, mouse); 0 (Nestin); 0 (Oligodeoxyribonucleotides); 0 (Pancreatitis-Associated Proteins); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (Protein Precursors); 0 (Proteins); 0 (RNA, Messenger); 0 (Reg1 protein, mouse); 0 (Reg3b protein, mouse); 0 (Tumor Necrosis Factor-alpha); 0 (interleukin-6, mouse); 51110-01-1 (Somatostatin); 55963-74-1 (Proglucagon); 61116-24-3 (preproinsulin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.1152/ajpendo.00104.2016


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[PMID]:27167163
[Au] Autor:Ehlers CL; Gizer IR; Bizon C; Slutske W; Peng Q; Schork NJ; Wilhelmsen KC
[Ad] Endereço:The Scripps Research Institute, Molecular and Cellular Neuroscience Department, La Jolla, CA.
[Ti] Título:Single nucleotide polymorphisms in the REG-CTNNA2 region of chromosome 2 and NEIL3 associated with impulsivity in a Native American sample.
[So] Source:Genes Brain Behav;15(6):568-77, 2016 Jul.
[Is] ISSN:1601-183X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Impulsivity is a multi-faceted construct that, while characterized by a set of correlated dimensions, is centered around a core definition that involves acting suddenly in an unplanned manner without consideration for the consequences of such behavior. Several psychiatric disorders include impulsivity as a criterion, and thus it has been suggested that it may link a number of different behavioral disorders, including substance abuse. Native Americans (NA) experience some of the highest rates of substance abuse of all the US ethnic groups. The described analyses used data from a low-coverage whole genome sequence scan to conduct a genome-wide association study (GWAS) of an impulsivity phenotype in an American Indian community sample (n = 658). Demographic and clinical information were obtained using a semi-structured interview. Impulsivity was assessed using a scale derived from the Maudsley personality inventory that combines both novelty seeking and lack of planning items. The impulsivity score was tested for association with each variant adjusted for demographic variables, and corrected for ancestry and kinship, using emmax. Simulations were conducted to calculate empirical P-values. Genome-wide significant findings were observed for a variant 50-kb upstream from catenin cadherin-associated protein, alpha 2 (CTNNA2), a neuronal-specific catenin, in the REG gene cluster. A meta-analysis of GWAS had previously identified common variants in CTNNA2 as being associated with excitement seeking. A second locus upstream of nei endonuclease VIII-like 3 (NEIL3) on chromosome 4 also achieved genome-wide significance. The association between sequence variants in these regions suggests their potential roles in the genetic regulation of this phenotype in this population.
[Mh] Termos MeSH primário: Cromossomos Humanos Par 2/genética
Comportamento Impulsivo
Índios Norte-Americanos/genética
N-Glicosil Hidrolases/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Litostatina/genética
Masculino
Meia-Idade
alfa Catenina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CTNNA2 protein, human); 0 (Lithostathine); 0 (REG1A protein, human); 0 (alpha Catenin); EC 3.2.2.- (FLJ10858 protein, human); EC 3.2.2.- (N-Glycosyl Hydrolases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170701
[Lr] Data última revisão:
170701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE
[do] DOI:10.1111/gbb.12297


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[PMID]:27055226
[Au] Autor:Kitayama Y; Fukui H; Hara K; Eda H; Kodani M; Yang M; Sun C; Yamagishi H; Tomita T; Oshima T; Watari J; Takasawa S; Miwa H
[Ad] Endereço:Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
[Ti] Título:Role of regenerating gene I in claudin expression and barrier function in the small intestine.
[So] Source:Transl Res;173:92-100, 2016 Jul.
[Is] ISSN:1878-1810
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have recently shown that loss of the regenerating gene (Reg) I causes susceptibility to nonsteroidal anti-inflammatory drug-induced gastrointestinal damage. However, the mechanism by which Reg I plays a protective role against this pathophysiological condition is unclear. Here, we investigated whether Reg I plays roles in the induction of tight junction proteins and mucosal barrier function in the small intestine. The small-intestinal permeability was evaluated in Reg I-deficient mice by FITC-dextran and transepithelial electrical resistance (TEER) assay. The effect of REG Iα on TEER, claudins expression, and intracellular signaling was examined using Caco2 cells in vitro. Small-intestinal expression of claudins 3 and 4 was investigated in Reg I-deficient mice in vivo. REG I deficiency significantly decreased the expression of claudin 3 in the small-intestinal epithelium. When mice were treated with indomethacin, the serum level of FITC-dextran in Reg I knockout mice was significantly higher than that in wild-type (WT) mice. The level of small-intestinal TEER was significantly decreased in Reg I knockout mice compared with WT mice under normal condition. REG Iα stimulation significantly enhanced the level of TEER in Caco2 cells. Treatment with REG Iα enhanced the expression of claudins 3 and 4 and promoted Sp1, Akt, and ERK phosphorylation in Caco2 cells, whereas these effects were attenuated by treatment with anti-REG Iα antibody. Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
[Mh] Termos MeSH primário: Claudinas/metabolismo
Intestino Delgado/metabolismo
Litostatina/metabolismo
[Mh] Termos MeSH secundário: Animais
Células CACO-2
Permeabilidade da Membrana Celular
Impedância Elétrica
Células Epiteliais/metabolismo
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Seres Humanos
Mucosa Intestinal/metabolismo
Camundongos Knockout
Fosforilação
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais
Fator de Transcrição Sp1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Claudins); 0 (Lithostathine); 0 (REG1A protein, human); 0 (Reg1 protein, mouse); 0 (Sp1 Transcription Factor); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE


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[PMID]:26867151
[Au] Autor:Sato Y; Motoyama S; Saito H; Minamiya Y
[Ad] Endereço:Department of Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
[Ti] Título:Novel Candidate Biomarkers of Chemoradiosensitivity in Esophageal Squamous Cell Carcinoma: A Systematic Review.
[So] Source:Eur Surg Res;56(3-4):141-53, 2016.
[Is] ISSN:1421-9921
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:There is no doubt that, along with surgery, chemoradiotherapy is an important treatment for esophageal squamous cell carcinoma (ESCC). Patients who respond well to chemoradiotherapy obtain great benefits toward overcoming their cancer, and so a more favorable prognosis. On the other hand, patients who do not respond well have wasted valuable time and experienced severe toxicity and seriously diminished quality of life, only to have their cancer recur with an unfavorable prognosis. For this reason, a reliable biomarker of chemoradiosensitivity in ESCC has long been sought. In this review, we will enumerate recently reported candidate biomarkers of chemoradiosensitivity in ESCC that have the potential for future clinical application.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Carcinoma de Células Escamosas/terapia
Quimiorradioterapia
Neoplasias Esofágicas/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Antígeno Ki-67/análise
Litostatina/análise
Fator 2 Relacionado a NF-E2/análise
Receptores de Interleucina-6/sangue
Fator A de Crescimento do Endotélio Vascular/sangue
Fator A de Crescimento do Endotélio Vascular/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Ki-67 Antigen); 0 (Lithostathine); 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (REG1A protein, human); 0 (Receptors, Interleukin-6); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160212
[St] Status:MEDLINE
[do] DOI:10.1159/000443607


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[PMID]:26776522
[Au] Autor:Cao S; Su X; Zeng B; Yan H; Huang Y; Wang E; Yun H; Zhang Y; Liu F; Li W; Wei H; Che Y; Yang R
[Ad] Endereço:Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
[Ti] Título:The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation.
[So] Source:Cell Rep;14(4):695-707, 2016 Feb 02.
[Is] ISSN:2211-1247
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Commensal microbes are necessary for a healthy gut immune system. However, the mechanism involving these microbes that establish and maintain gut immune responses is largely unknown. Here, we have found that the gut immune receptor leucine-rich repeat (LRR) C19 is involved in host-microbiota interactions. LRRC19 deficiency not only impairs the gut immune system but also reduces inflammatory responses in gut tissues. We demonstrate that the LRRC19-associated chemokines CCL6, CCL9, CXCL9, and CXCL10 play a critical role in immune cell recruitment and intestinal inflammation. The expression of these chemokines is associated with regenerating islet-derived (REG) protein-mediated microbiotas. We also found that the expression of REGs may be regulated by gut Lactobacillus through LRRC19-mediated activation of NF-κB. Therefore, our study establishes a regulatory axis of LRRC19, REGs, altered microbiotas, and chemokines for the recruitment of immune cells and the regulation of intestinal inflammation.
[Mh] Termos MeSH primário: Colite Ulcerativa/imunologia
Receptores de Superfície Celular/metabolismo
[Mh] Termos MeSH secundário: Animais
Quimiocinas/genética
Quimiocinas/metabolismo
Células Dendríticas/imunologia
Feminino
Mucosa Intestinal/citologia
Mucosa Intestinal/imunologia
Mucosa Intestinal/microbiologia
Lactobacillus/isolamento & purificação
Lactobacillus/metabolismo
Litostatina/genética
Litostatina/metabolismo
Macrófagos/imunologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Microbiota
NF-kappa B/metabolismo
Receptores de Superfície Celular/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chemokines); 0 (LRRC19 protein, mouse); 0 (Lithostathine); 0 (NF-kappa B); 0 (Receptors, Cell Surface)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE



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