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  1 / 1827 MEDLINE  
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[PMID]:28917668
[Au] Autor:Gao C; Ganesh BP; Shi Z; Shah RR; Fultz R; Major A; Venable S; Lugo M; Hoch K; Chen X; Haag A; Wang TC; Versalovic J
[Ad] Endereço:Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
[Ti] Título:Gut Microbe-Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production.
[So] Source:Am J Pathol;187(10):2323-2336, 2017 Oct.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microbiome-mediated suppression of carcinogenesis may open new avenues for identification of therapeutic targets and prevention strategies in oncology. Histidine decarboxylase (HDC) deficiency has been shown to promote inflammation-associated colorectal cancer by accumulation of CD11b Gr-1 immature myeloid cells, indicating a potential antitumorigenic effect of histamine. Here, we demonstrate that administration of hdc Lactobacillus reuteri in the gut resulted in luminal hdc gene expression and histamine production in the intestines of Hdc mice. This histamine-producing probiotic decreased the number and size of colon tumors and colonic uptake of [ F]-fluorodeoxyglucose by positron emission tomography in Hdc mice. Administration of L. reuteri suppressed keratinocyte chemoattractant (KC), Il22, Il6, Tnf, and IL1α gene expression in the colonic mucosa and reduced the amounts of proinflammatory, cancer-associated cytokines, keratinocyte chemoattractant, IL-22, and IL-6, in plasma. Histamine-generating L. reuteri also decreased the relative numbers of splenic CD11b Gr-1 immature myeloid cells. Furthermore, an isogenic HDC-deficient L. reuteri mutant that was unable to generate histamine did not suppress carcinogenesis, indicating a significant role of the cometabolite, histamine, in suppression of chronic intestinal inflammation and colorectal tumorigenesis. These findings link luminal conversion of amino acids to biogenic amines by gut microbes and probiotic-mediated suppression of colorectal neoplasia.
[Mh] Termos MeSH primário: Carcinogênese/patologia
Neoplasias Colorretais/patologia
Microbioma Gastrointestinal
Histamina/biossíntese
Inflamação/patologia
[Mh] Termos MeSH secundário: Animais
Carcinogênese/genética
Neoplasias Colorretais/sangue
Neoplasias Colorretais/diagnóstico por imagem
Neoplasias Colorretais/genética
Citocinas/sangue
Regulação Neoplásica da Expressão Gênica
Histidina Descarboxilase/genética
Histidina Descarboxilase/metabolismo
Seres Humanos
Inflamação/sangue
Inflamação/genética
Mucosa Intestinal/patologia
Lactobacillus reuteri/metabolismo
Camundongos Endogâmicos BALB C
Modelos Biológicos
Células Mieloides/metabolismo
Tomografia por Emissão de Pósitrons
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Receptores Histamínicos H2/genética
Receptores Histamínicos H2/metabolismo
Baço/patologia
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (RNA, Messenger); 0 (Receptors, Histamine H2); 820484N8I3 (Histamine); EC 4.1.1.22 (Histidine Decarboxylase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE


  2 / 1827 MEDLINE  
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[PMID]:28436624
[Au] Autor:Zhang L; Chen G; Chen J; He X; Hu X
[Ad] Endereço:Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
[Ti] Título:[Mechanisms of histamine ameliorating memory impairment induced by pentylenetetrazole-kindling epilepsy in rats].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;46(1):1-6, 2017 Jan 25.
[Is] ISSN:1008-9292
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the effects of neuronal histamine on spatial memory acquisition impairment in rats with pentylenetetrazole-kindling epilepsy, and to explore its mechanisms. A subconvulsive dose of pentylenetetrazole (35 mg/kg) was intraperitoneally injected in rats every 48 h to induce chemical kindling until fully kindled. Morris water maze was used to measure the spatial memory acquisition of the rats one week after fully pentylenetetrazole-kindled, and the histamine contents in different brain areas were measured spectrofluorometrically. Different dosages of hitidine (the precursor of histamine), pyrilamine (H1 receptor antagonist), and zolantidine (H2 receptor antagonist) were intraperitoneally injected, and their effects on spatial memory acquisition of the rats were observed. Compared with control group, escape latencies were significantly prolonged on Morris water maze training day 2 and day 3 in pentylenetetrazole-kindling epilepsy rats (all <0.05); and the histamine contents in hippocampus, thalamus and hypothalamus were decreased significantly (all <0.05). Escape latencies were markedly shortened on day 3 by intraperitoneally injected with histidine 500 mg/kg, and on day 2 and day 3 by intraperitoneally injected with histidine 1000 mg/kg in pentylenetetrazole-kindling epilepsy rats (all <0.05). The protection of histidine was reversed by zolantidine (10 and 20 mg/kg), but not by pyrilamine. Neuronal histamine can improve the spatial memory acquisition impairment in rats with pentylenetetrazole-kindling epilepsy, and the activation of H2 receptors is possibly involved in the protective effects of histamine.
[Mh] Termos MeSH primário: Transtornos da Memória/tratamento farmacológico
Receptores Histamínicos H2/efeitos dos fármacos
Receptores Histamínicos H2/fisiologia
Memória Espacial/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Benzotiazóis/farmacologia
Química Encefálica/efeitos dos fármacos
Epilepsia/induzido quimicamente
Epilepsia/complicações
Hipocampo/química
Antagonistas dos Receptores Histamínicos H1/farmacologia
Antagonistas dos Receptores Histamínicos H2/farmacologia
Histidina/farmacologia
Hipotálamo/química
Excitação Neurológica/fisiologia
Transtornos da Memória/etiologia
Pentilenotetrazol
Fenoxipropanolaminas/farmacologia
Piperidinas/farmacologia
Pirilamina/farmacologia
Ratos
Ratos Sprague-Dawley
Espectrometria de Fluorescência
Tálamo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzothiazoles); 0 (Histamine H1 Antagonists); 0 (Histamine H2 Antagonists); 0 (Phenoxypropanolamines); 0 (Piperidines); 0 (Receptors, Histamine H2); 4QD397987E (Histidine); HPE317O9TL (Pyrilamine); M1108XAY01 (zolantidine); WM5Z385K7T (Pentylenetetrazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  3 / 1827 MEDLINE  
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[PMID]:28235771
[Au] Autor:Rydström A; Hallner A; Aurelius J; Sander FE; Bernson E; Kiffin R; Thoren FB; Hellstrand K; Martner A
[Ad] Endereço:TIMM Laboratory, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden.
[Ti] Título:Dynamics of myeloid cell populations during relapse-preventive immunotherapy in acute myeloid leukemia.
[So] Source:J Leukoc Biol;102(2):467-474, 2017 Aug.
[Is] ISSN:1938-3673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Relapse of leukemia in the postchemotherapy phase contributes to the poor prognosis and survival in patients with acute myeloid leukemia (AML). In an international phase IV trial (ClinicalTrials.gov; NCT01347996), 84 patients with AML in first complete remission who had not undergone transplantation received immunotherapy with histamine dihydrochloride (HDC) and low-dose IL-2 with the aim of preventing relapse. The dynamics of myeloid cell counts and expression of activation markers was assessed before and after cycles of immunotherapy and correlated with clinical outcome in terms of relapse risk and survival. During cycles, a pronounced increase in blood eosinophil counts was observed along with a reduction in monocyte and neutrophil counts. A strong reduction of blood monocyte counts during the first HDC/IL-2 treatment cycle predicted leukemia-free survival. The HDC component of the immunotherapy exerts agonist activity at histamine type 2 receptors (H2Rs) that are expressed by myeloid cells. It was observed that the density of H R expression in blood monocytes increased during cycles of immunotherapy and that high monocyte H R expression implied reduced relapse risk and improved overall survival. Several other activation markers, including HLA-DR, CD86, and CD40, were induced in monocytes and dendritic cells during immunotherapy but did not predict clinical outcome. In addition, expression of HLA-ABC increased in all myeloid populations during therapy. A low expression of HLA-ABC was associated with reduced relapse risk. These results suggest that aspects of myeloid cell biology may impact clinical benefit of relapse-preventive immunotherapy in AML.
[Mh] Termos MeSH primário: Imunoterapia/métodos
Leucemia Mieloide Aguda/imunologia
Células Mieloides/imunologia
Recidiva Local de Neoplasia/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antineoplásicos/uso terapêutico
Biomarcadores Tumorais/análise
Contagem de Células
Feminino
Citometria de Fluxo
Histamina/uso terapêutico
Seres Humanos
Interleucina-2/uso terapêutico
Leucemia Mieloide Aguda/prevenção & controle
Masculino
Meia-Idade
Monócitos
Células Mieloides/efeitos dos fármacos
Receptores Histamínicos H2/biossíntese
Indução de Remissão
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE IV; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biomarkers, Tumor); 0 (Interleukin-2); 0 (Receptors, Histamine H2); 820484N8I3 (Histamine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE
[do] DOI:10.1189/jlb.5VMA1116-455R


  4 / 1827 MEDLINE  
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[PMID]:28188663
[Au] Autor:Cilz NI; Lei S
[Ad] Endereço:Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota.
[Ti] Título:Histamine facilitates GABAergic transmission in the rat entorhinal cortex: Roles of H and H receptors, Na -permeable cation channels, and inward rectifier K channels.
[So] Source:Hippocampus;27(5):613-631, 2017 May.
[Is] ISSN:1098-1063
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the brain, histamine (HA) serves as a neuromodulator and a neurotransmitter released from the tuberomammillary nucleus (TMN). HA is involved in wakefulness, thermoregulation, energy homeostasis, nociception, and learning and memory. The medial entorhinal cortex (MEC) receives inputs from the TMN and expresses HA receptors (H , H , and H ). We investigated the effects of HA on GABAergic transmission in the MEC and found that HA significantly increased the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) with an EC of 1.3 µM, but failed to significantly alter sIPSC amplitude. HA-induced increases in sIPSC frequency were sensitive to tetrodotoxin (TTX), required extracellular Ca , and persisted when GDP-ß-S, a G-protein inactivator, was applied postsynaptically via the recording pipettes, indicating that HA increased GABA release by facilitating the excitability of GABAergic interneurons in the MEC. Recordings from local MEC interneurons revealed that HA significantly increased their excitability as determined by membrane depolarization, generation of an inward current at -65 mV, and augmentation of action potential firing frequency. Both H and H receptors were involved in HA-induced increases in sIPSCs and interneuron excitability. Immunohistochemical staining showed that both H and H receptors are expressed on GABAergic interneurons in the MEC. HA-induced depolarization of interneurons involved a mixed ionic mechanism including activation of a Na -permeable cation channel and inhibition of a cesium-sensitive inward rectifier K channel, although HA also inhibited the delayed rectifier K channels. Our results may provide a cellular mechanism, at least partially, to explain the roles of HA in the brain. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Córtex Entorrinal/metabolismo
Histamina/metabolismo
Interneurônios/metabolismo
Transmissão Sináptica/fisiologia
Ácido gama-Aminobutírico/metabolismo
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Potenciais de Ação/fisiologia
Animais
Cálcio/metabolismo
Cátions/metabolismo
Césio/metabolismo
Córtex Entorrinal/citologia
Córtex Entorrinal/efeitos dos fármacos
Agonistas dos Receptores Histamínicos/farmacologia
Antagonistas dos Receptores Histamínicos/farmacologia
Interneurônios/citologia
Interneurônios/efeitos dos fármacos
Canais de Potássio Corretores do Fluxo de Internalização/metabolismo
Ratos Sprague-Dawley
Receptores de GABA-A/metabolismo
Receptores Histamínicos H1/metabolismo
Receptores Histamínicos H2/metabolismo
Receptores Histamínicos H3/metabolismo
Bloqueadores dos Canais de Sódio/farmacologia
Canais de Sódio/metabolismo
Transmissão Sináptica/efeitos dos fármacos
Técnicas de Cultura de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Histamine Agonists); 0 (Histamine Antagonists); 0 (Potassium Channels, Inwardly Rectifying); 0 (Receptors, GABA-A); 0 (Receptors, Histamine H1); 0 (Receptors, Histamine H2); 0 (Receptors, Histamine H3); 0 (Sodium Channel Blockers); 0 (Sodium Channels); 1KSV9V4Y4I (Cesium); 56-12-2 (gamma-Aminobutyric Acid); 820484N8I3 (Histamine); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1002/hipo.22718


  5 / 1827 MEDLINE  
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[PMID]:27316911
[Au] Autor:Monczor F; Copsel S; Fernandez N; Davio C; Shayo C
[Ad] Endereço:Instituto de Investigaciones Farmacológicas, ININFA, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Junín 956 PP, (1113), Buenos Aires, Argentina. monczorf@ffyb.uba.ar.
[Ti] Título:Histamine H Receptor in Blood Cells: A Suitable Target for the Treatment of Acute Myeloid Leukemia.
[So] Source:Handb Exp Pharmacol;241:141-160, 2017.
[Is] ISSN:0171-2004
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Acute myeloid leukemia (AML) consists in a cancer of early hematopoietic cells arising in the bone marrow, most often of those cells that would turn into white blood cells (except lymphocytes). Chemotherapy is the treatment of choice for AML but one of the major complications is that current drugs are highly toxic and poorly tolerated. In general, treatment for AML consists of induction chemotherapy and post-remission therapy. If no further post-remission is given, almost all patients will eventually relapse. Histamine, acting at histamine type-2 (H ) receptors on phagocytes and AML blast cells, helps prevent the production and release of oxygen-free radicals, thereby protecting NK and cytotoxic T cells. This protection allows immune-stimulating agents, such as interleukin-2 (IL-2), to activate cytotoxic cells more effectively, enhancing the killing of tumor cells. Based on this mechanism, post-remission therapy with histamine and IL-2 was found to significantly prevent relapse of AML. Alternatively, another potentially less toxic approach to treat AML employs drugs to induce differentiation of malignant cells. It is based on the assumption that many neoplastic cell types exhibit reversible defects in differentiation, which upon appropriate treatment results in tumor reprogramming and the induction of terminal differentiation. There are promissory results showing that an elevated and sustained signaling through H receptors is able to differentiate leukemia-derived cell lines, opening the door for the use of H agonists for specific differentiation therapies. In both situations, histamine acting through H receptors constitutes an eligible treatment to induce leukemic cell differentiation, improving combined therapies.
[Mh] Termos MeSH primário: Células Sanguíneas/metabolismo
Leucemia Mieloide Aguda/metabolismo
Receptores Histamínicos H2/sangue
Receptores Histamínicos H2/metabolismo
[Mh] Termos MeSH secundário: Histamina/metabolismo
Seres Humanos
Interleucina-2/metabolismo
Leucemia Mieloide Aguda/sangue
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Interleukin-2); 0 (Receptors, Histamine H2); 820484N8I3 (Histamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160619
[St] Status:MEDLINE
[do] DOI:10.1007/164_2016_8


  6 / 1827 MEDLINE  
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[PMID]:26864348
[Au] Autor:Schwittlick U; Junginger J; Hahn K; Habierski A; Hewicker-Trautwein M
[Ad] Endereço:Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559, Hannover, Germany.
[Ti] Título:Histamine Receptor Expression in the Gastrointestinal Tract of Dogs.
[So] Source:Anat Histol Embryol;46(1):33-42, 2017 Feb.
[Is] ISSN:1439-0264
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Histamine is an important mediator of many physiological processes including gastrointestinal function that acts via four different histamine receptors (H1R to H4R). Elevated histamine levels and increased HR messenger ribonucleic acid (mRNA) have been shown in humans with gastrointestinal disorders such as irritable bowel syndrome or allergic intestinal diseases. As there is limited knowledge concerning the distribution of histamine receptors (HR) in dogs, one aim of this study was to investigate the expression of histamine 1 receptor (H1R), histamine 2 receptor (H2R) and histamine 4 receptor (H4R) in the canine gastrointestinal tract at protein level using immunohistochemistry. Histamine 1 receptor, H2R and H4R were widely expressed throughout the canine gastrointestinal tract including epithelial, mesenchymal, neuronal and immune cells. In addition, in situ hybridisation was established for detecting canine H4R mRNA. Results showed H4R mRNA to be present in enterocytes, lamina propria immune cells and submucosal plexus in the duodenum and colon of nearly all investigated animals. The results elucidate the importance of HR in the canine gut and represent the basis for investigating their possible impact on canine inflammatory gastrointestinal disorders.
[Mh] Termos MeSH primário: Cães
Trato Gastrointestinal/metabolismo
Receptores Histamínicos H1/biossíntese
Receptores Histamínicos H2/biossíntese
[Mh] Termos MeSH secundário: Animais
Células Epiteliais/metabolismo
Feminino
Gastroenteropatias/patologia
Masculino
Mesoderma/metabolismo
Membrana Mucosa/metabolismo
RNA Mensageiro/genética
Receptores Histamínicos H1/genética
Receptores Histamínicos H2/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Receptors, Histamine H1); 0 (Receptors, Histamine H2)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160212
[St] Status:MEDLINE
[do] DOI:10.1111/ahe.12229


  7 / 1827 MEDLINE  
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[PMID]:27863547
[Au] Autor:Sullivant A; Mackin A; Pharr T; Cooley J; Wills R; Archer T
[Ad] Endereço:Departments of Clinical Sciences, Mississippi State University College of Veterinary Medicine, 240 Wise Center Drive, MS, MS 39762, United States. Electronic address: asullivant@cvm.msstate.edu.
[Ti] Título:Identification of histamine receptors in the canine gastrointestinal tract.
[So] Source:Vet Immunol Immunopathol;182:29-36, 2016 Dec.
[Is] ISSN:1873-2534
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The important role of histamine in chronic gastrointestinal diseases has been increasingly recognized over the last two decades in human medicine. Histamine is released following mast cell activation and exerts its action through binding to four different histamine receptors (H1, H2, H3, and H4). Histamine receptors are dispersed throughout the body, and each different receptor mediates a unique response. Documentation of the presence and type of histamine receptors in the differing sections of the canine gastrointestinal tract will provide additional research opportunities to further explore the role of histamine and its receptors in chronic canine enteropathies, as well as potential therapeutic options. Full thickness gastric, duodenal, jejunal, ileal, and colonic biopsies were obtained from 6 clinically normal adult dogs immediately after humane euthanasia. Commercially available histamine receptor antibodies predicted to react with canine tissues were applied to paraffin-embedded tissue sections using standard immunohistochemistry techniques to identify different histamine receptors. Staining intensity was graded from negative to strong, and the specificity of each antibody was evaluated with western blot. The presence and distribution of histamine receptors varied by anatomic site and histologic level within sections of the canine gastrointestinal tract. All 4 histamine receptors were readily identified, although the distribution of H4 receptors was decreased in comparison to the other histamine receptors. The distribution of the various histamine receptors was similar to that seen in the normal human gastrointestinal tract. H1 receptors were located in the stomach, lymphoid tissue of the ileum and colon, and the smooth muscle and ganglia of all sections. H2 receptors were located in all sections of the gastrointestinal tract, with greatest staining intensity in the gastric mucosa. H3 receptors were located in the stomach and colonic mucosa, smooth muscle and ganglia of all sections, and ileal and colonic lymphoid tissue. H4 receptors were located in the ganglia and smooth muscle of the gastrointestinal tract, as well as the gastric and colonic mucosal and ileal lymphoid tissue. Western blot demonstrated both specific and non-specific staining with the H1 and H3 receptor antibody, but good specificity with the H4 receptor antibody. The H2 receptor antibody was not compatible with western blot techniques, despite excellent immunohistochemical specificity and consistency. Further studies to compare the density and distribution of the various histamine receptors in dogs with gastrointestinal disease are warranted.
[Mh] Termos MeSH primário: Cães/metabolismo
Trato Gastrointestinal/metabolismo
Receptores Histamínicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Western Blotting
Cães/imunologia
Trato Gastrointestinal/imunologia
Seres Humanos
Imuno-Histoquímica
Receptores Histamínicos/imunologia
Receptores Histamínicos H1/metabolismo
Receptores Histamínicos H2/metabolismo
Receptores Histamínicos H3/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Histamine); 0 (Receptors, Histamine H1); 0 (Receptors, Histamine H2); 0 (Receptors, Histamine H3)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


  8 / 1827 MEDLINE  
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[PMID]:27723909
[Au] Autor:Steffen HM
[Ti] Título:[Stress ulcer prophylaxis: are PPIs truly superior compared to H2 receptor antagonists?]
[Ti] Título:Stressulkusprophylaxe: Sind PPIs den H2-Rezeptorantagonisten wirklich überlegen?.
[So] Source:Z Gastroenterol;54(10):1168-1169, 2016 Oct.
[Is] ISSN:1439-7803
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:The S2k-Guideline "Helicobacter pylori and gastroduodenal ulcer disease" offers a statement and comment on the subject of stress ulcer prophylaxis that need a critical response.
[Mh] Termos MeSH primário: Infecções por Helicobacter
Receptores Histamínicos H2
[Mh] Termos MeSH secundário: Helicobacter pylori
Antagonistas dos Receptores Histamínicos H2
Seres Humanos
Úlcera Péptica
Inibidores da Bomba de Prótons
Úlcera
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histamine H2 Antagonists); 0 (Proton Pump Inhibitors); 0 (Receptors, Histamine H2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


  9 / 1827 MEDLINE  
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[PMID]:27693797
[Au] Autor:Tamaddonfard E; Erfanparast A; Ghasemi H; Henareh-Chareh F; Hadidi M; Mirzakhani N; Seyedin S; Taati M; Salighedar R; Salimi S; Safaei F
[Ad] Endereço:Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia 5756151818, Iran. Electronic address: e_tamaddonfard@yahoo.com.
[Ti] Título:The role of histamine H , H and H receptors of ventral posteromedial nucleus of thalamus in modulation of trigeminal pain.
[So] Source:Eur J Pharmacol;791:696-702, 2016 Nov 15.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Histamine receptors are involved in supraspinal modulation of pain. In the present study, we investigated the effects of microinjection of histamine H , H and H receptor antagonists and agonists into the ventral posteromedial (VPM) nucleus of the thalamus on two models of trigeminal pain. Right and left sides of VPM were implanted with two guide cannulas. Corneal pain was induced by local corneal surface application of hypertonic saline and the number of eye wipes was recorded. The duration of face rubbing, as an orofacial pain measure, was recorded after subcutaneous (s.c.) injection of capsaicin into the vibrissa pad. 2-pyridylethylamine (2-PEA, a histamine H receptor agonist, 4µg/site) and dimaprit (a histamine H receptor agonist, 1 and 4µg/site) suppressed corneal and orofacial pains. Mepyramine (a histamine H receptor antagonist) and ranitidine (a histamine H receptor antagonist) at the similar doses of 0.5, 2 and 8µg/site alone had no effects on trigeminal pain. Prior microinjection of mepyramine and ranitidine at a similar dose of 8µg/site inhibited the antinociceptive effects of 2-PEA (4µg/site) and dimaprit (4µg/site), respectively. Immepip (a histamine H receptor agonist, 1 and 4µg/site) increased, and thioperamide (a histamine H receptor antagonist, 2 and 8µg/site) attenuated nociceptive responses. Prior microinjection of thioperamide (8µg/site) prevented immepip (4µg/site)-induced nociception. These chemicals did not change locomotor behavior. It is concluded that post-synaptic histamine H , and to a lesser extent H , receptors and pre-synaptic histamine H receptor may be involved in VPM modulation of trigeminal pain.
[Mh] Termos MeSH primário: Dor Facial/metabolismo
Receptores Histamínicos/metabolismo
Núcleos Ventrais do Tálamo/metabolismo
[Mh] Termos MeSH secundário: Animais
Dor Facial/fisiopatologia
Masculino
Ratos
Ratos Wistar
Receptores Histamínicos H1/metabolismo
Receptores Histamínicos H2/metabolismo
Receptores Histamínicos H3/metabolismo
Nervo Trigêmeo/metabolismo
Nervo Trigêmeo/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Histamine); 0 (Receptors, Histamine H1); 0 (Receptors, Histamine H2); 0 (Receptors, Histamine H3)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


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[PMID]:27625037
[Au] Autor:Monczor F; Fernandez N
[Ad] Endereço:Instituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina monczorf@ffyb.uba.ar.
[Ti] Título:Current Knowledge and Perspectives on Histamine H1 and H2 Receptor Pharmacology: Functional Selectivity, Receptor Crosstalk, and Repositioning of Classic Histaminergic Ligands.
[So] Source:Mol Pharmacol;90(5):640-648, 2016 Nov.
[Is] ISSN:1521-0111
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:H and H histamine receptor antagonists, although developed many decades ago, are still effective for the treatment of allergic and gastric acid-related conditions. This article focuses on novel aspects of the pharmacology and molecular mechanisms of histamine receptors that should be contemplated for optimizing current therapies, repositioning histaminergic ligands for new therapeutic uses, or even including agonists of the histaminergic system in the treatment of different pathologies such as leukemia or neurodegenerative disorders. In recent years, new signaling phenomena related to H and H receptors have been described that make them suitable for novel therapeutic approaches. Crosstalk between histamine receptors and other membrane or nuclear receptors can be envisaged as a way to modulate other signaling pathways and to potentiate the efficacy of drugs acting on different receptors. Likewise, biased signaling at histamine receptors seems to be a pharmacological feature that can be exploited to investigate nontraditional therapeutic uses for H and H biased agonists in malignancies such as acute myeloid leukemia and to avoid undesired side effects when used in standard treatments. It is hoped that the molecular mechanisms discussed in this review contribute to a better understanding of the different aspects involved in histamine receptor pharmacology, which in turn will contribute to increased drug efficacy, avoidance of adverse effects, or repositioning of histaminergic ligands.
[Mh] Termos MeSH primário: Histamina/metabolismo
Receptor Cross-Talk
Receptores Histamínicos H1/metabolismo
Receptores Histamínicos H2/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Ligantes
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ligands); 0 (Receptors, Histamine H1); 0 (Receptors, Histamine H2); 820484N8I3 (Histamine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE



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