Base de dados : MEDLINE
Pesquisa : D12.776.543.750.695.160.500.625 [Categoria DeCS]
Referências encontradas : 202 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 21 ir para página                         

  1 / 202 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28855310
[Au] Autor:Zaid A; Hor JL; Christo SN; Groom JR; Heath WR; Mackay LK; Mueller SN
[Ad] Endereço:Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000 Australia.
[Ti] Título:Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation.
[So] Source:J Immunol;199(7):2451-2459, 2017 Oct 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Infection or inflammation of the skin recruits effector CD8 T cells that enter the epidermis and form populations of long-lived tissue-resident memory T (T ) cells. These skin T cells migrate within the constrained epidermal environment by extending multiple dynamic dendritic projections and squeezing between keratinocytes to survey the tissue for pathogens. In this study, we examined the signals required for this distinctive mode of T cell migration by inhibiting key cytoskeletal components and performing intravital two-photon microscopy to visualize T cell behavior. We found that T cell motility and dendrite formation required an intact actomyosin cytoskeleton and the Rho-associated coiled-coil containing kinases. We also identified an essential role for microtubules for maintaining skin T cell shape and cellular integrity. We reveal a role for pertussis toxin-sensitive signaling for T cell dendritic morphology and migration that is independent of CXCR3 or CXCR6, or the skin-selective chemokine receptors CCR10 and CCR8. However, we found that CXCR6 and CCR10 expression by CD8 T cells was required for the optimal formation of memory T cell populations, in particular T cell populations in the skin.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/fisiologia
Movimento Celular
Epiderme/imunologia
Memória Imunológica
Receptores de Quimiocinas/metabolismo
Pele/imunologia
[Mh] Termos MeSH secundário: Actomiosina/metabolismo
Animais
Linfócitos T CD8-Positivos/imunologia
Células Dendríticas/fisiologia
Epiderme/citologia
Microscopia Intravital/métodos
Camundongos
Microtúbulos/metabolismo
Toxina Pertussis/metabolismo
Receptores CCR10/genética
Receptores CCR10/metabolismo
Receptores CCR8/metabolismo
Receptores CXCR/genética
Receptores CXCR/metabolismo
Receptores CXCR3/metabolismo
Receptores CXCR6
Receptores de Quimiocinas/genética
Transdução de Sinais
Pele/anatomia & histologia
Pele/citologia
Quinases Associadas a rho/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ccr10 protein, mouse); 0 (Cxcr6 protein, mouse); 0 (Receptors, CCR10); 0 (Receptors, CCR8); 0 (Receptors, CXCR); 0 (Receptors, CXCR3); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 9013-26-7 (Actomyosin); EC 2.4.2.31 (Pertussis Toxin); EC 2.7.11.1 (rho-Associated Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700571


  2 / 202 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28526759
[Au] Autor:Pallett LJ; Davies J; Colbeck EJ; Robertson F; Hansi N; Easom NJW; Burton AR; Stegmann KA; Schurich A; Swadling L; Gill US; Male V; Luong T; Gander A; Davidson BR; Kennedy PTF; Maini MK
[Ad] Endereço:Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, England, UK.
[Ti] Título:IL-2 tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.
[So] Source:J Exp Med;214(6):1567-1580, 2017 Jun 05.
[Is] ISSN:1540-9538
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The liver provides a tolerogenic immune niche exploited by several highly prevalent pathogens as well as by primary and metastatic tumors. We have sampled healthy and hepatitis B virus (HBV)-infected human livers to probe for a subset of T cells specialized to overcome local constraints and mediate immunity. We characterize a population of T-bet Eomes Blimp-1 Hobit T cells found within the intrahepatic but not the circulating memory CD8 T cell pool expressing liver-homing/retention markers (CD69 CD103 CXCR6 CXCR3 ). These tissue-resident memory T cells (T ) are preferentially expanded in patients with partial immune control of HBV infection and can remain in the liver after the resolution of infection, including compartmentalized responses against epitopes within all major HBV proteins. Sequential IL-15 or antigen exposure followed by TGFß induces liver-adapted T , including their signature high expression of exhaustion markers PD-1 and CD39. We suggest that these inhibitory molecules, together with paradoxically robust, rapid, cell-autonomous IL-2 and IFNγ production, equip liver CD8 T to survive while exerting local noncytolytic hepatic immunosurveillance.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/imunologia
Interleucina-2/metabolismo
Fígado/imunologia
Fígado/virologia
[Mh] Termos MeSH secundário: Antígenos/imunologia
Antígenos CD/metabolismo
Comunicação Autócrina/efeitos dos fármacos
Linfócitos T CD8-Positivos/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Granzimas/metabolismo
Vírus da Hepatite B/efeitos dos fármacos
Hepatite B Crônica/imunologia
Hepatite B Crônica/patologia
Hepatite B Crônica/virologia
Seres Humanos
Memória Imunológica/efeitos dos fármacos
Interleucina-15/farmacologia
Fígado/efeitos dos fármacos
Fígado/patologia
Fenótipo
Receptor de Morte Celular Programada 1/metabolismo
Receptores de Antígenos de Linfócitos T/metabolismo
Receptores CXCR6
Receptores de Quimiocinas/metabolismo
Receptores Virais/metabolismo
Fator de Crescimento Transformador beta/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens); 0 (Antigens, CD); 0 (CXCR6 protein, human); 0 (Interleukin-15); 0 (Interleukin-2); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 0 (Receptors, Antigen, T-Cell); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, Virus); 0 (Transforming Growth Factor beta); EC 3.4.21.- (Granzymes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170521
[St] Status:MEDLINE
[do] DOI:10.1084/jem.20162115


  3 / 202 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28428094
[Au] Autor:Picton ACP; Paximadis M; Chaisson RE; Martinson NA; Tiemessen CT
[Ad] Endereço:Centre for HIV and STIs, National Institute for Communicable Diseases, NHLS, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
[Ti] Título:CXCR6 gene characterization in two ethnically distinct South African populations and association with viraemic disease control in HIV-1-infected black South African individuals.
[So] Source:Clin Immunol;180:69-79, 2017 Jul.
[Is] ISSN:1521-7035
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CXCR6 genetic variation was described for HIV-1-uninfected black (n=41) and Caucasian (n=40) South Africans. We also investigated the CXCR6 rs2234358 and rs2234355 single nucleotide polymorphisms in HIV-1 disease control in 124 HIV-1-infected drug-naïve black individuals [elite controllers (n=11), viraemic controllers (VCs, n=30), high viral load long-term nonprogressors (HVL LTNPs, n=11) and progressors (n=72)] compared to healthy controls (HCs; n=232). The rs2234358-T allele was underrepresented in VCs (40.0%) compared to HCs (59%, P=0.006), HVL LTNPs (72.7%, P=0.012) and progressors (59%, P=0.014). The rs2234358-TT genotype was underrepresented in VCs (7%) compared to progressors (32%; OR=6.57, P=0.006) and HCs (35%; OR=7.18, P=0.001, P =0.034). The rs2234355-GA genotype was overrepresented in VCs (80%) compared to HCs (50.4%; OR=0.25, P=0.003) and progressors (29.17%; OR=0.10, P=3.8×10 , P =0.001). The combination of rs2234355-GA in the absence of rs2234358-TT was overrepresented in VCs (80%) compared to HCs (32.6%, OR=0.12, P=1×10 , P =3.4×10 ) and to progressors (16.7%; OR=0.05, P<1×10 , P <1×10 ).
[Mh] Termos MeSH primário: Grupo com Ancestrais do Continente Africano/genética
Grupo com Ancestrais do Continente Europeu/genética
Infecções por HIV/genética
Receptores de Quimiocinas/genética
Receptores Virais/genética
Viremia/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Infecções por HIV/virologia
HIV-1
Haplótipos
Seres Humanos
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
Receptores CXCR6
África do Sul
Carga Viral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CXCR6 protein, human); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, Virus)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


  4 / 202 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28267793
[Au] Autor:Koenen A; Babendreyer A; Schumacher J; Pasqualon T; Schwarz N; Seifert A; Deupi X; Ludwig A; Dreymueller D
[Ad] Endereço:Institute of Pharmacology and Toxicology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
[Ti] Título:The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion.
[So] Source:PLoS One;12(3):e0173486, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The CXC-chemokine receptor 6 (CXCR6) is a class A GTP-binding protein-coupled receptor (GPCRs) that mediates adhesion of leukocytes by interacting with the transmembrane cell surface-expressed chemokine ligand 16 (CXCL16), and also regulates leukocyte migration by interacting with the soluble shed variant of CXCL16. In contrast to virtually all other chemokine receptors with chemotactic activity, CXCR6 carries a DRF motif instead of the typical DRY motif as a key element in receptor activation and G protein coupling. In this work, modeling analyses revealed that the phenylalanine F3.51 in CXCR6 might have impact on intramolecular interactions including hydrogen bonds by this possibly changing receptor function. Initial investigations with embryonic kidney HEK293 cells and further studies with monocytic THP-1 cells showed that mutation of DRF into DRY does not influence ligand binding, receptor internalization, receptor recycling, and protein kinase B (AKT) signaling. Adhesion was slightly decreased in a time-dependent manner. However, CXCL16-induced calcium signaling and migration were increased. Vice versa, when the DRY motif of the related receptor CX3CR1 was mutated into DRF the migratory response towards CX3CL1 was diminished, indicating that the presence of a DRF motif generally impairs chemotaxis in chemokine receptors. Transmembrane and soluble CXCL16 play divergent roles in homeostasis, inflammation, and cancer, which can be beneficial or detrimental. Therefore, the DRF motif of CXCR6 may display a receptor adaptation allowing adhesion and cell retention by transmembrane CXCL16 but reducing the chemotactic response to soluble CXCL16. This adaptation may avoid permanent or uncontrolled recruitment of inflammatory cells as well as cancer metastasis.
[Mh] Termos MeSH primário: Adaptação Biológica
Motivos de Aminoácidos
Adesão Celular
Receptores de Quimiocinas/química
Receptores de Quimiocinas/metabolismo
Receptores Virais/química
Receptores Virais/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Sinalização do Cálcio
Linhagem Celular
Membrana Celular
Movimento Celular
Quimiotaxia
Expressão Gênica
Seres Humanos
Ligantes
Modelos Moleculares
Ligação Proteica
Conformação Proteica
Transporte Proteico
Proteínas Proto-Oncogênicas c-akt/metabolismo
Receptores CXCR6
Receptores de Quimiocinas/genética
Receptores Virais/genética
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CXCR6 protein, human); 0 (Ligands); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, Virus); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173486


  5 / 202 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27869573
[Au] Autor:Gruber HE; Marrero E; Ingram JA; Hoelscher GL; Hanley EN
[Ad] Endereço:a Department of Orthopaedic Surgery , Carolinas Medical Center , Charlotte , North Carolina.
[Ti] Título:The chemokine, CXCL16, and its receptor, CXCR6, are constitutively expressed in human annulus fibrosus and expression of CXCL16 is up-regulated by exposure to IL-1ß in vitro.
[So] Source:Biotech Histochem;92(1):7-14, 2017.
[Is] ISSN:1473-7760
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemokines are an important group of soluble molecules with specialized functions in inflammation. The roles of many specialized chemokines and their receptors remain poorly understood in the human intervertebral disc. We investigated CXCL16 and its receptor, CXCR6, to determine their immunolocalization in disc tissue and their presence following exposure of cultured human annulus fibrosus cells to proinflammatory cytokines. CXCL16 is a marker for inflammation; it also can induce hypoxia-inducible factor 1α (HIF-1α), which is a phenotypic marker of heathy nucleus pulposus tissue. We found CXCL16 and CXCR6 immunostaining in many cells of the annulus portion of the disc. Molecular studies showed that annulus fibrosus cells exposed to IL-1ß, but not TNF-α, exhibited significant up-regulation of CXCL16 expression vs. control cells. There was no significant difference in the percentage of annulus cells that exhibited immunolocalization of CXCL16 in grade I/II, grade III or grade IV/V specimens. The presence of CXCL16 and its receptor, CXCR6, in the annulus in vivo suggests the need for future research concerning the role of this chemokine in proinflammatory functions, HIF-1α expression and disc vascularization.
[Mh] Termos MeSH primário: Anel Fibroso/metabolismo
Quimiocinas CXC/metabolismo
Interleucina-1beta/farmacologia
Receptores de Quimiocinas/metabolismo
Receptores Depuradores/metabolismo
Receptores Virais/metabolismo
[Mh] Termos MeSH secundário: Anel Fibroso/citologia
Técnicas de Cultura de Células
Células Cultivadas
Quimiocina CXCL16
Quimiocinas CXC/genética
Seres Humanos
Transporte Proteico
Receptores CXCR6
Receptores de Quimiocinas/genética
Receptores Depuradores/genética
Receptores Virais/genética
Fator de Necrose Tumoral alfa/farmacologia
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CXCL16 protein, human); 0 (CXCR6 protein, human); 0 (Chemokine CXCL16); 0 (Chemokines, CXC); 0 (Interleukin-1beta); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, Scavenger); 0 (Receptors, Virus); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1080/10520295.2016.1237672


  6 / 202 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27823764
[Au] Autor:Ma Y; Xu X; Luo M
[Ad] Endereço:Department of Developmental Biology, Jinzhou Medical University, Jinzhou, Liaoning 121001, PR China.
[Ti] Título:CXCR6 promotes tumor cell proliferation and metastasis in osteosarcoma through the Akt pathway.
[So] Source:Cell Immunol;311:80-85, 2017 Jan.
[Is] ISSN:1090-2163
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chemokine (C-X-C motif) receptor 6 (CXCR6) is up-regulated in many malignancies, indicating that CXCR6 plays an important role in tumor progression. However, the expression and function of CXCR6 in osteosarcoma (OS) remains unclear. This study aimed to explore the expression levels and function of CXCR6 in OS tissues and osteosarcoma cell lines MG-63, HOS and U2OS. The protein expression levels of CXCR6 in OS patient tissues and three osteosarcoma cell lines MG-63, HOS and U2OS were assessed. CXCR6-overexpression MG-63 cell lines were established and then the proliferation, invasion and the epithelial-mesenchymal transition (EMT) in those cells were assessed. CXCR6 mRNA levels in OS tissues were significantly higher than those in normal bone tissues. Consistently, both of the mRNA and protein levels of CXCR6 in OS cell lines MG-63, HOS and U2OS were higher than those in normal bone cells hFOB1.19. CXCR6 overexpression not only promoted cell proliferation, invasion and EMT, but also enhanced the phosphorylation of Akt in MG-63 cells. After inhibition of Akt-phosphorylation by Akt inhibitor, LY2940023, CXCR6-induced cell proliferation and invasion were dramatically attenuated. In conclusion, the present study demonstrated that CXCR6 enhances OS cell proliferation and invasion through the Akt pathway.
[Mh] Termos MeSH primário: Osteoblastos/fisiologia
Osteossarcoma/imunologia
Receptores de Quimiocinas/metabolismo
Receptores Virais/metabolismo
[Mh] Termos MeSH secundário: Carcinogênese
Linhagem Celular Tumoral
Movimento Celular
Proliferação Celular
Transição Epitelial-Mesenquimal
Regulação da Expressão Gênica
Seres Humanos
Proteína Oncogênica v-akt/metabolismo
Fosforilação/efeitos dos fármacos
Receptores CXCR6
Receptores de Quimiocinas/genética
Receptores Virais/genética
Transdução de Sinais
Fator de Crescimento Transformador beta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CXCR6 protein, human); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, Virus); 0 (Transforming Growth Factor beta); EC 2.7.11.1 (Oncogene Protein v-akt)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


  7 / 202 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27693347
[Au] Autor:Brant SR; Okou DT; Simpson CL; Cutler DJ; Haritunians T; Bradfield JP; Chopra P; Prince J; Begum F; Kumar A; Huang C; Venkateswaran S; Datta LW; Wei Z; Thomas K; Herrinton LJ; Klapproth JA; Quiros AJ; Seminerio J; Liu Z; Alexander JS; Baldassano RN; Dudley-Brown S; Cross RK; Dassopoulos T; Denson LA; Dhere TA; Dryden GW; Hanson JS; Hou JK; Hussain SZ; Hyams JS; Isaacs KL; Kader H; Kappelman MD; Katz J; Kellermayer R; Kirschner BS; Kuemmerle JF; Kwon JH; Lazarev M; Li E; Mack D; Mannon P; Moulton DE; Newberry RD; Osuntokun BO; Patel AS; Saeed SA; Targan SR
[Ad] Endereço:Department of Medicine, Meyerhoff Inflammatory Bowel Disease Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
[Ti] Título:Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.
[So] Source:Gastroenterology;152(1):206-217.e2, 2017 Jan.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIMS: The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD) cause significant morbidity and are increasing in prevalence among all populations, including African Americans. More than 200 susceptibility loci have been identified in populations of predominantly European ancestry, but few loci have been associated with IBD in other ethnicities. METHODS: We performed 2 high-density, genome-wide scans comprising 2345 cases of African Americans with IBD (1646 with CD, 583 with UC, and 116 inflammatory bowel disease unclassified) and 5002 individuals without IBD (controls, identified from the Health Retirement Study and Kaiser Permanente database). Single-nucleotide polymorphisms (SNPs) associated at P < 5.0 × 10 in meta-analysis with a nominal evidence (P < .05) in each scan were considered to have genome-wide significance. RESULTS: We detected SNPs at HLA-DRB1, and African-specific SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for UC. We detected SNPs at USP25 with associations of genome-wide significance for IBD. No associations of genome-wide significance were detected for CD. In addition, 9 genes previously associated with IBD contained SNPs with significant evidence for replication (P < 1.6 × 10 ): ADCY3, CXCR6, HLA-DRB1 to HLA-DQA1 (genome-wide significance on conditioning), IL12B,PTGER4, and TNC for IBD; IL23R, PTGER4, and SNX20 (in strong linkage disequilibrium with NOD2) for CD; and KCNQ2 (near TNFRSF6B) for UC. Several of these genes, such as TNC (near TNFSF15), CXCR6, and genes associated with IBD at the HLA locus, contained SNPs with unique association patterns with African-specific alleles. CONCLUSIONS: We performed a genome-wide association study of African Americans with IBD and identified loci associated with UC in only this population; we also replicated IBD, CD, and UC loci identified in European populations. The detection of variants associated with IBD risk in only people of African descent demonstrates the importance of studying the genetics of IBD and other complex diseases in populations beyond those of European ancestry.
[Mh] Termos MeSH primário: Afroamericanos/genética
Moléculas de Adesão Celular Neuronais/genética
Colite Ulcerativa/genética
Doença de Crohn/genética
Predisposição Genética para Doença/genética
Cadeias HLA-DRB1/genética
Proteínas Repressoras/genética
Ubiquitina Tiolesterase/genética
[Mh] Termos MeSH secundário: Adenilil Ciclases/genética
Estudos de Casos e Controles
Grupo com Ancestrais do Continente Europeu/genética
Proteínas Ligadas por GPI/genética
Estudo de Associação Genômica Ampla
Técnicas de Genotipagem
Cadeias alfa de HLA-DQ/genética
Seres Humanos
Subunidade p40 da Interleucina-12/genética
Canal de Potássio KCNQ2/genética
Polimorfismo de Nucleotídeo Único
Receptores CXCR6
Receptores de Quimiocinas/genética
Receptores de Interleucina/genética
Receptores de Prostaglandina E Subtipo EP4/genética
Receptores Virais/genética
Nexinas de Classificação/genética
Tenascina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; MULTICENTER STUDY
[Nm] Nome de substância:
0 (CXCR6 protein, human); 0 (Cell Adhesion Molecules, Neuronal); 0 (GPI-Linked Proteins); 0 (HLA-DQ alpha-Chains); 0 (HLA-DQA1 antigen); 0 (HLA-DRB1 Chains); 0 (IL12B protein, human); 0 (IL23R protein, human); 0 (Interleukin-12 Subunit p40); 0 (KCNQ2 Potassium Channel); 0 (KCNQ2 protein, human); 0 (PTGER4 protein, human); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, Interleukin); 0 (Receptors, Prostaglandin E, EP4 Subtype); 0 (Receptors, Virus); 0 (Repressor Proteins); 0 (SNX20 protein, human); 0 (Sorting Nexins); 0 (Tenascin); 0 (ZNF649 protein, human); 0 (limbic system-associated membrane protein); EC 3.1.2.15 (USP25 protein, human); EC 3.4.19.12 (Ubiquitin Thiolesterase); EC 4.6.1.1 (Adenylyl Cyclases); EC 4.6.1.1 (adenylate cyclase 3)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


  8 / 202 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27877078
[Au] Autor:Hu ZB; Chen Y; Gong YX; Gao M; Zhang Y; Wang GH; Tang RN; Liu H; Liu BC; Ma KL
[Ad] Endereço:Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
[Ti] Título:Activation of the CXCL16/CXCR6 Pathway by Inflammation Contributes to Atherosclerosis in Patients with End-stage Renal Disease.
[So] Source:Int J Med Sci;13(11):858-867, 2016.
[Is] ISSN:1449-1907
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Chronic inflammation plays a critical role in the progression of atherosclerosis (AS). This study aimed to determine the effects of the CXC chemokine ligand 16 (CXCL16)/CXC chemokine receptor 6 (CXCR6) pathway on cholesterol accumulation in the radial arteries of end-stage renal disease (ESRD) patients with concomitant microinflammation and to further investigate the potential effects of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7R). Forty-three ESRD patients were divided into the control group (n=17) and the inflamed group (n=26) based on plasma C-reactive protein (CRP) levels. Biochemical indexes and lipid profiles of the patients were determined. Surgically removed tissues from the radial arteries of patients receiving arteriovenostomy were used for preliminary evaluation of AS. Haematoxylin-eosin (HE) and Filipin staining were performed to assess foam cell formation. CXCL16/CXCR6 pathway-related protein expression, P2X7R protein expression and the expression of monocyte chemotactic protein-1 (MCP-1), tumour necrosis factor-α (TNF-α), and CD68 were detected by immunohistochemical and immunofluorescence staining. Inflammation increased both MCP-1 and TNF-α expression and macrophage infiltration in radial arteries. Additionally, foam cell formation significantly increased in the radial arteries of the inflamed group compared to that of the controls. Further analysis showed that protein expression of CXCL16, CXCR6, disintegrin and metalloproteinase-10 (ADAM10) in the radial arteries of the inflamed group was significantly increased. Furthermore, CXCL16 expression was positively correlated with P2X7R expression in the radial arteries of ESRD patients. Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 pathway, which may be regulated by P2X7R.
[Mh] Termos MeSH primário: Aterosclerose/etiologia
Quimiocinas CXC/metabolismo
Inflamação/complicações
Falência Renal Crônica/complicações
Receptores de Quimiocinas/metabolismo
Receptores Depuradores/metabolismo
Receptores Virais/metabolismo
[Mh] Termos MeSH secundário: Proteína ADAM10/metabolismo
Adulto
Idoso
Secretases da Proteína Precursora do Amiloide/metabolismo
Aterosclerose/metabolismo
Quimiocina CCL2/metabolismo
Quimiocina CXCL16
Quimiocinas CXC/genética
Feminino
Seres Humanos
Inflamação/metabolismo
Falência Renal Crônica/metabolismo
Masculino
Proteínas de Membrana/metabolismo
Meia-Idade
Receptores CXCR6
Receptores de Quimiocinas/genética
Receptores Purinérgicos P2X7/metabolismo
Receptores Depuradores/genética
Receptores Virais/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCL2 protein, human); 0 (CXCL16 protein, human); 0 (CXCR6 protein, human); 0 (Chemokine CCL2); 0 (Chemokine CXCL16); 0 (Chemokines, CXC); 0 (Membrane Proteins); 0 (P2RX7 protein, human); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, Purinergic P2X7); 0 (Receptors, Scavenger); 0 (Receptors, Virus); 0 (Tumor Necrosis Factor-alpha); EC 3.4.- (Amyloid Precursor Protein Secretases); EC 3.4.24.81 (ADAM10 Protein); EC 3.4.24.81 (ADAM10 protein, human)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


  9 / 202 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27720639
[Au] Autor:Yoon MS; Pham CT; Phan MT; Shin DJ; Jang YY; Park MH; Kim SK; Kim S; Cho D
[Ad] Endereço:Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: meesunyoon@jnu.ac.kr.
[Ti] Título:Irradiation of breast cancer cells enhances CXCL16 ligand expression and induces the migration of natural killer cells expressing the CXCR6 receptor.
[So] Source:Cytotherapy;18(12):1532-1542, 2016 Dec.
[Is] ISSN:1477-2566
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AIMS: Few studies have examined the migration pattern of natural killer (NK) cells, especially after radiation treatment for cancer. We investigated whether irradiation can modulate the expression of chemokines in cancer cells and the migration of NK cells to irradiated tumor cells. METHODS: The expression of chemokine receptors (CXCR3, CXCR4 and CXCR6) on interleukin-2 (IL-2)/IL-15-activated NK cells was assessed using flow cytometry. Related chemokine ligands (CXCL11, CXCL12 and CXCL16) in human breast cancer cell lines (MCF7, SKBR3 and MDA-MB231) irradiated at various doses were assessed using reverse transcription-polymerase chain reaction (RT-PCR), fluorescence-activated cell sorting (FACS) and enzyme-linked immunosorbent assay (ELISA). The cell-free culture supernatant was collected 96 h after irradiation of breast cancer cell lines for migration and blocking assays. RESULTS: The activated NK cells expressed CXCR6. Expression of the CXCR6 ligand CXCL16 increased in a time- and dose-dependent manner in all analyzed cancer cell lines. CXCL16 expression was statistically significantly enhanced in all breast cancer cell lines on day 3 after 20 Gy irradiation. Activated NK cells migration correlated with CXCL16 concentration (R = 0.91; P <0.0001). Significantly enhanced migration of NK cells to irradiated cancer cells was observed for a dose of 20 Gy in MCF7 (P = 0.043) and SKBR3 (P = 0.043) cells, but not in MDA-MB231 (P = 0.225) cells. A blocking assay using a CXCR6 antibody showed a significant decrease in the migration of activated NK cells in all cancer cell lines. CONCLUSIONS: Our data indicate that irradiation induces CXCL16 chemokine expression in cancer cells and enhances the migration of activated NK cells expressing CXCR6 to irradiated breast cancer cells. These results suggest that radiation would improve the anti-tumor effect of NK cells through enhanced migration of NK cells to tumor site for the treatment of patients with breast cancer.
[Mh] Termos MeSH primário: Neoplasias da Mama/radioterapia
Movimento Celular/efeitos da radiação
Quimiocinas CXC/biossíntese
Células Matadoras Naturais/imunologia
Receptores de Quimiocinas/biossíntese
Receptores Depuradores/biossíntese
Receptores Virais/biossíntese
[Mh] Termos MeSH secundário: Anticorpos Bloqueadores/farmacologia
Linhagem Celular Tumoral
Quimiocina CXCL12/biossíntese
Quimiocina CXCL16
Ensaio de Imunoadsorção Enzimática
Feminino
Citometria de Fluxo
Seres Humanos
Interleucina-15/metabolismo
Interleucina-2/metabolismo
Células Matadoras Naturais/metabolismo
Células MCF-7
Receptores CXCR3/biossíntese
Receptores CXCR4/biossíntese
Receptores CXCR6
Receptores de Quimiocinas/imunologia
Receptores Virais/imunologia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Transdução de Sinais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Blocking); 0 (CXCL12 protein, human); 0 (CXCL16 protein, human); 0 (CXCR3 protein, human); 0 (CXCR4 protein, human); 0 (CXCR6 protein, human); 0 (Chemokine CXCL12); 0 (Chemokine CXCL16); 0 (Chemokines, CXC); 0 (Interleukin-15); 0 (Interleukin-2); 0 (Receptors, CXCR3); 0 (Receptors, CXCR4); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, Scavenger); 0 (Receptors, Virus)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


  10 / 202 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27316557
[Au] Autor:Arthur G; Bradding P
[Ad] Endereço:Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, England.
[Ti] Título:New Developments in Mast Cell Biology: Clinical Implications.
[So] Source:Chest;150(3):680-93, 2016 Sep.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mast cells (MCs) are present in connective tissue and at mucosal surfaces in all classes of vertebrates. In health, they contribute to tissue homeostasis, host defense, and tissue repair via multiple receptors regulating the release of a vast stockpile of proinflammatory mediators, proteases, and cytokines. However, these potentially protective cells are a double-edged sword. When there is a repeated or long-term stimulus, MC activation leads to tissue damage and dysfunction. Accordingly, MCs are implicated in the pathophysiologic aspects of numerous diseases covering all organs. Understanding the biology of MCs, their heterogeneity, mechanisms of activation, and signaling cascades may lead to the development of novel therapies for many diseases for which current treatments are lacking or are of poor efficacy. This review will focus on updates and developments in MC biology and their clinical implications, with a particular focus on their role in respiratory diseases.
[Mh] Termos MeSH primário: Asma/imunologia
Citocinas/imunologia
Hipertensão Pulmonar/imunologia
Fibrose Pulmonar Idiopática/imunologia
Mastócitos/imunologia
Pneumonia/imunologia
Doença Pulmonar Obstrutiva Crônica/imunologia
Fumar/imunologia
[Mh] Termos MeSH secundário: Molécula 1 de Adesão Celular
Moléculas de Adesão Celular
Seres Humanos
Imunoglobulina E/imunologia
Imunoglobulinas
Terapia de Alvo Molecular
Receptores CXCR4
Receptores CXCR6
Receptores de Quimiocinas
Receptores de IgE/imunologia
Receptores Virais
Transdução de Sinais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (CADM1 protein, human); 0 (CXCR4 protein, human); 0 (CXCR6 protein, human); 0 (Cell Adhesion Molecule-1); 0 (Cell Adhesion Molecules); 0 (Cytokines); 0 (Immunoglobulins); 0 (Receptors, CXCR4); 0 (Receptors, CXCR6); 0 (Receptors, Chemokine); 0 (Receptors, IgE); 0 (Receptors, Virus); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160619
[St] Status:MEDLINE



página 1 de 21 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde