Base de dados : MEDLINE
Pesquisa : D12.776.543.750.695.650 [Categoria DeCS]
Referências encontradas : 940 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 94 ir para página                         

  1 / 940 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28836858
[Au] Autor:Dede AD; Makras P; Anastasilakis AD
[Ad] Endereço:a Department of Endocrinology and Diabetes , Chelsea and Westminster Hospital , London , UK.
[Ti] Título:Investigational anabolic agents for the treatment of osteoporosis: an update on recent developments.
[So] Source:Expert Opin Investig Drugs;26(10):1137-1144, 2017 Oct.
[Is] ISSN:1744-7658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Teriparatide, a PTH analogue, was the first anabolic agent to be approved for the treatment of osteoporosis in 2002. Abaloparatide was also recently approved by the FDA. The need for other anabolic agents is still unmet. Areas covered: In this review, we discuss target molecules and recent advances in the field of anabolic therapy for osteoporosis. PTH and PTHrP analogues binding to the PTH receptor and different routes of administration of teriparatide to avoid the burden of daily subcutaneous injections are discussed. We also review antibodies targeting suppressors of the Wnt pathway such as sclerostin and Dickopff-1. Expert opinion: The development of alternative ways of administering PTH receptor ligands is a promising field, especially via the transdermal route. Other more promising molecules are still at very early stages of development. FDA recently requested more data on Romosozumab.
[Mh] Termos MeSH primário: Anabolizantes/uso terapêutico
Drogas em Investigação/uso terapêutico
Osteoporose/tratamento farmacológico
[Mh] Termos MeSH secundário: Anabolizantes/administração & dosagem
Anabolizantes/farmacologia
Animais
Desenho de Drogas
Drogas em Investigação/administração & dosagem
Drogas em Investigação/farmacologia
Seres Humanos
Terapia de Alvo Molecular
Osteoporose/fisiopatologia
Proteína Relacionada ao Hormônio Paratireóideo/administração & dosagem
Proteína Relacionada ao Hormônio Paratireóideo/uso terapêutico
Receptores de Hormônios Paratireóideos/metabolismo
Teriparatida/administração & dosagem
Teriparatida/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anabolic Agents); 0 (Drugs, Investigational); 0 (Parathyroid Hormone-Related Protein); 0 (Receptors, Parathyroid Hormone); 10T9CSU89I (Teriparatide); AVK0I6HY2U (abaloparatide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1080/13543784.2017.1371136


  2 / 940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27908723
[Au] Autor:Ardura JA; Alonso V; Esbrit P; Friedman PA
[Ad] Endereço:Instituto de Medicina Molecular Aplicada (IMMA)-Universidad San Pablo CEU, Madrid, Spain; Laboratorio de Metabolismo Mineral y Óseo, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, UAM and Red Temática de Investigación Cooperativa de Envejecimiento y Fragilidad (RETICEF)-Instituto
[Ti] Título:Oxidation inhibits PTH receptor signaling and trafficking.
[So] Source:Biochem Biophys Res Commun;482(4):1019-1024, 2017 Jan 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reactive Oxygen Species (ROS) increase during aging, potentially affecting many tissues including brain, heart, and bone. ROS alter signaling pathways and constitute potential therapeutic targets to limit oxidative damaging effects in aging-associated diseases. Parathyroid hormone receptors (PTHR) are widely expressed and PTH is the only anabolic therapy for osteoporosis. The effects of oxidative stress on PTHR signaling and trafficking have not been elucidated. Here, we used Fluorescence Resonance Energy Transfer (FRET)-based cAMP, ERK, and calcium fluorescent biosensors to analyze the effects of ROS on PTHR signaling and trafficking by live-cell imaging. PTHR internalization and recycling were measured in HEK-293 cells stably transfected with HA-PTHR. PTH increased cAMP production, ERK phosphorylation, and elevated intracellular calcium. Pre-incubation with H O reduced all PTH-dependent signaling pathways. These inhibitory effects were not a result of PTH oxidation since PTH incubated with H O triggered similar responses. PTH promoted internalization and recycling of the PTHR. Both events were significantly reduced by H O pre-incubation. These findings highlight the role of oxidation on PTHR signaling and trafficking, and suggest the relevance of ROS as a putative target in diseases associated with oxidative stress such as age-related osteoporosis.
[Mh] Termos MeSH primário: Estresse Oxidativo
Receptores de Hormônios Paratireóideos/metabolismo
Transdução de Sinais
[Mh] Termos MeSH secundário: AMP Cíclico/metabolismo
Transferência Ressonante de Energia de Fluorescência
Células HEK293
Seres Humanos
Peróxido de Hidrogênio/metabolismo
Transporte Proteico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Parathyroid Hormone); BBX060AN9V (Hydrogen Peroxide); E0399OZS9N (Cyclic AMP)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


  3 / 940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27065162
[Au] Autor:Khundmiri SJ; Murray RD; Lederer E
[Ad] Endereço:Department of Medicine, University of Louisville, Louisville, Kentucky, USA.
[Ti] Título:PTH and Vitamin D.
[So] Source:Compr Physiol;6(2):561-601, 2016 Mar 15.
[Is] ISSN:2040-4603
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles in the maintenance of calcium and phosphate homeostasis as well as the development and maintenance of bone health. PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. The major function of PTH and major physiologic regulator is circulating ionized calcium. The effects of PTH on gut, kidney, and bone serve to maintain serum calcium within a tight range. PTH has a reciprocal effect on phosphate metabolism. In contrast, vitamin D has a stimulatory effect on both calcium and phosphate homeostasis, playing a key role in providing adequate mineral for normal bone formation. Both hormones act in concert with the more recently discovered FGF23 and klotho, hormones involved predominantly in phosphate metabolism, which also participate in this closely knit feedback circuit. Of great interest are recent studies demonstrating effects of both PTH and vitamin D on the cardiovascular system. Hyperparathyroidism and vitamin D deficiency have been implicated in a variety of cardiovascular disorders including hypertension, atherosclerosis, vascular calcification, and kidney failure. Both hormones have direct effects on the endothelium, heart, and other vascular structures. How these effects of PTH and vitamin D interface with the regulation of bone formation are the subject of intense investigation.
[Mh] Termos MeSH primário: Doenças das Paratireoides/metabolismo
Hormônio Paratireóideo/metabolismo
Deficiência de Vitamina D/metabolismo
Vitamina D/metabolismo
[Mh] Termos MeSH secundário: Animais
Cálcio/metabolismo
Seres Humanos
Hormônio Paratireóideo/sangue
Hormônio Paratireóideo/química
Receptores de Calcitriol/metabolismo
Receptores de Hormônios Paratireóideos/metabolismo
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; REVIEW
[Nm] Nome de substância:
0 (Parathyroid Hormone); 0 (Receptors, Calcitriol); 0 (Receptors, Parathyroid Hormone); 1406-16-2 (Vitamin D); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160412
[St] Status:MEDLINE
[do] DOI:10.1002/cphy.c140071


  4 / 940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26448640
[Au] Autor:Riddle RC
[Ad] Endereço:Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
[Ti] Título:Parathyroid Hormone Reprograms Osteoblast Metabolism.
[So] Source:J Bone Miner Res;30(11):1956-8, 2015 Nov.
[Is] ISSN:1523-4681
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Osteoblastos/metabolismo
Hormônio Paratireóideo/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Proteína Relacionada ao Hormônio Paratireóideo/metabolismo
Receptores de Hormônios Paratireóideos/metabolismo
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Parathyroid Hormone); 0 (Parathyroid Hormone-Related Protein); 0 (Receptors, Parathyroid Hormone)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151009
[St] Status:MEDLINE
[do] DOI:10.1002/jbmr.2727


  5 / 940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25913526
[Au] Autor:Linglart A; Silve C; Rothenbuhler A
[Ad] Endereço:Endocrinology and diabetology for children, Paris 11 University, French center of reference for rare disorders of calcium and phosphorus metabolism, Bicêtre-Paris-Sud Hospital, Le Kremlin-Bicêtre, France; Inserm U1169, Bicêtre-Paris-Sud Hospital, Le Kremlin-Bicêtre, France. Electronic address: agnes.linglart@bct.aphp.fr.
[Ti] Título:Multiple hormonal resistances: Diagnosis, evaluation and therapy.
[So] Source:Ann Endocrinol (Paris);76(2):98-100, 2015 May.
[Is] ISSN:2213-3941
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Molecular alterations of cAMP-mediated signaling affect primarily the signaling of the PTH/PTHrp receptor, and, with different severities the signaling of other hormones, including TSH. The identification of PTH and other hormonal resistances implies to look for the genetic disorder supporting the metabolic disorder.
[Mh] Termos MeSH primário: Doenças das Paratireoides/terapia
Hormônio Paratireóideo/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Doenças das Paratireoides/diagnóstico
Doenças das Paratireoides/fisiopatologia
Pseudo-Hipoparatireoidismo/genética
Pseudo-Hipoparatireoidismo/terapia
Receptores de Hormônios Paratireóideos/genética
Receptores de Hormônios Paratireóideos/metabolismo
Tireotropina/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Parathyroid Hormone); 0 (Receptors, Parathyroid Hormone); 9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:161031
[Lr] Data última revisão:
161031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150428
[St] Status:MEDLINE


  6 / 940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25744000
[Au] Autor:Feng Y; Zhou M; Zhang Q; Liu H; Xu Y; Shu L; Zhang J; Miao D; Ren Y
[Ad] Endereço:Department of Orthopaedics,The First Affiliated Hospital, Nanjing Medical University,Nanjing, Jiangsu,People's Republic of China.
[Ti] Título:Synergistic effects of high dietary calcium and exogenous parathyroid hormone in promoting osteoblastic bone formation in mice.
[So] Source:Br J Nutr;113(6):909-22, 2015 Mar 28.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present study, we investigated whether high dietary Ca and exogenous parathyroid hormone 1-34 fragments (PTH 1-34) have synergistic effects on bone formation in adult mice, and explored the related mechanisms. Adult male mice were fed a normal diet, a high-Ca diet, a PTH-treated diet, or a high-Ca diet combined with subcutaneously injected PTH 1-34 (80 µg/kg per d) for 4 weeks. Bone mineral density, trabecular bone volume, osteoblast number, alkaline phosphatase (ALP)- and type I collagen-positive areas, and the expression levels of osteoblastic bone formation-related genes and proteins were increased significantly in mice fed the high-Ca diet, the PTH-treated diet, and, even more dramatically, the high-Ca diet combined with PTH. Osteoclast number and surface and the ratio of receptor activator for nuclear factor-κB ligand (RANKL):osteoprotegerin (OPG) were decreased in the high-Ca diet treatment group, increased in the PTH treatment group, but not in the combined treatment group. Furthermore, third-passage osteoblasts were treated with high Ca (5 mM), PTH 1-34 (10⁻8 M) or high Ca combined with PTH 1-34. Osteoblast viability and ALP activity were increased in either the high Ca-treated or PTH-treated cultures and, even more dramatically, in the cultures treated with high Ca plus PTH, with consistent up-regulation of the expression levels of osteoblast proliferation and differentiation-related genes and proteins. These results indicate that dietary Ca and PTH play synergistic roles in promoting osteoblastic bone formation by stimulating osteoblast proliferation and differentiation.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/uso terapêutico
Reabsorção Óssea/prevenção & controle
Cálcio na Dieta/uso terapêutico
Interações Alimento-Droga
Osteoblastos/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
Hormônio Paratireóideo/análogos & derivados
Hormônio Paratireóideo/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Densidade Óssea/efeitos dos fármacos
Conservadores da Densidade Óssea/farmacologia
Reabsorção Óssea/metabolismo
Reabsorção Óssea/patologia
Osso e Ossos/efeitos dos fármacos
Osso e Ossos/metabolismo
Osso e Ossos/patologia
Canais de Cálcio/genética
Canais de Cálcio/metabolismo
Cálcio na Dieta/metabolismo
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Terapia Combinada
Masculino
Camundongos Endogâmicos C57BL
Osteoblastos/metabolismo
Osteoblastos/patologia
Hormônio Paratireóideo/farmacologia
Fragmentos de Peptídeos/farmacologia
Fragmentos de Peptídeos/uso terapêutico
Receptores de Detecção de Cálcio/agonistas
Receptores de Detecção de Cálcio/genética
Receptores de Detecção de Cálcio/metabolismo
Receptores de Hormônios Paratireóideos/agonistas
Receptores de Hormônios Paratireóideos/genética
Receptores de Hormônios Paratireóideos/metabolismo
Canais de Cátion TRPV/agonistas
Canais de Cátion TRPV/genética
Canais de Cátion TRPV/metabolismo
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 0 (Calcium Channels); 0 (Calcium, Dietary); 0 (Parathyroid Hormone); 0 (Peptide Fragments); 0 (Receptors, Calcium-Sensing); 0 (Receptors, Parathyroid Hormone); 0 (TRPV Cation Channels); 0 (Trpv6 protein, mouse)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150307
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114514004309


  7 / 940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25713287
[Au] Autor:Gardella TJ; Vilardaga JP
[Ad] Endereço:Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts (T.J.G.); and Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (J.-P.V.) Gardella@Helix.MGH.Harvard.edu.
[Ti] Título:International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.
[So] Source:Pharmacol Rev;67(2):310-37, 2015.
[Is] ISSN:1521-0081
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The type-1 parathyroid hormone receptor (PTHR1) is a family B G protein-coupled receptor (GPCR) that mediates the actions of two polypeptide ligands; parathyroid hormone (PTH), an endocrine hormone that regulates the levels of calcium and inorganic phosphate in the blood by acting on bone and kidney, and PTH-related protein (PTHrP), a paracrine-factor that regulates cell differentiation and proliferation programs in developing bone and other tissues. The type-2 parathyroid hormone receptor (PTHR2) binds a peptide ligand, called tuberoinfundibular peptide-39 (TIP39), and while the biologic role of the PTHR2/TIP39 system is not as defined as that of the PTHR1, it likely plays a role in the central nervous system as well as in spermatogenesis. Mechanisms of action at these receptors have been explored through a variety of pharmacological and biochemical approaches, and the data obtained support a basic "two-site" mode of ligand binding now thought to be used by each of the family B peptide hormone GPCRs. Recent crystallographic studies on the family B GPCRs are providing new insights that help to further refine the specifics of the overall receptor architecture and modes of ligand docking. One intriguing pharmacological finding for the PTHR1 is that it can form surprisingly stable complexes with certain PTH/PTHrP ligand analogs and thereby mediate markedly prolonged cell signaling responses that persist even when the bulk of the complexes are found in internalized vesicles. The PTHR1 thus appears to be able to activate the Gα(s)/cAMP pathway not only from the plasma membrane but also from the endosomal domain. The cumulative findings could have an impact on efforts to develop new drug therapies for the PTH receptors.
[Mh] Termos MeSH primário: AMP Cíclico/fisiologia
Subunidades alfa Gs de Proteínas de Ligação ao GTP/metabolismo
Modelos Moleculares
Receptores de Hormônios Paratireóideos/metabolismo
Sistemas do Segundo Mensageiro
[Mh] Termos MeSH secundário: Animais
Membrana Celular/enzimologia
Membrana Celular/metabolismo
Endossomos/enzimologia
Endossomos/metabolismo
Subunidades alfa Gs de Proteínas de Ligação ao GTP/química
Seres Humanos
Agências Internacionais
Ligantes
Farmacologia/tendências
Farmacologia Clínica/tendências
Isoformas de Proteínas/agonistas
Isoformas de Proteínas/química
Isoformas de Proteínas/classificação
Isoformas de Proteínas/metabolismo
Receptores de Hormônios Paratireóideos/agonistas
Receptores de Hormônios Paratireóideos/química
Receptores de Hormônios Paratireóideos/classificação
Sociedades Científicas
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ligands); 0 (Protein Isoforms); 0 (Receptors, Parathyroid Hormone); E0399OZS9N (Cyclic AMP); EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gs)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150226
[St] Status:MEDLINE
[do] DOI:10.1124/pr.114.009464


  8 / 940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25625518
[Au] Autor:Dale MD; Mortimer EM; Kolli S; Achramowicz E; Borchert G; Juliano SA; Halkyard S; Sietz N; Gatto C; Hester PY; Rubin DA
[Ad] Endereço:School of Biological Sciences, Illinois State University, Normal, IL 61701, USA. mddale@ilstu.edu.
[Ti] Título:Bone-remodeling transcript levels are independent of perching in end-of-lay white leghorn chickens.
[So] Source:Int J Mol Sci;16(2):2663-77, 2015 Jan 23.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Osteoporosis is a bone disease that commonly results in a 30% incidence of fracture in hens used to produce eggs for human consumption. One of the causes of osteoporosis is the lack of mechanical strain placed on weight-bearing bones. In conventionally-caged hens, there is inadequate space for chickens to exercise and induce mechanical strain on their bones. One approach is to encourage mechanical stress on bones by the addition of perches to conventional cages. Our study focuses on the molecular mechanism of bone remodeling in end-of-lay hens (71 weeks) with access to perches. We examined bone-specific transcripts that are actively involved during development and remodeling. Using real-time quantitative PCR, we examined seven transcripts (COL2A1 (collagen, type II, alpha 1), RANKL (receptor activator of nuclear factor kappa-B ligand), OPG (osteoprotegerin), PTHLH (PTH-like hormone), PTH1R (PTH/PTHLH type-1 receptor), PTH3R (PTH/PTHLH type-3 receptor), and SOX9 (Sry-related high mobility group box)) in phalange, tibia and femur. Our results indicate that the only significant effect was a difference among bones for COL2A1 (femur > phalange). Therefore, we conclude that access to a perch did not alter transcript expression. Furthermore, because hens have been used as a model for human bone metabolism and osteoporosis, the results indicate that bone remodeling due to mechanical loading in chickens may be a product of different pathways than those involved in the mammalian model.
[Mh] Termos MeSH primário: Remodelação Óssea/genética
Fêmur/metabolismo
Tíbia/metabolismo
[Mh] Termos MeSH secundário: Envelhecimento
Animais
Galinhas
Colágeno Tipo II/genética
Colágeno Tipo II/metabolismo
Feminino
Osteoprotegerina/genética
Osteoprotegerina/metabolismo
Proteína Relacionada ao Hormônio Paratireóideo/genética
Proteína Relacionada ao Hormônio Paratireóideo/metabolismo
Ligante RANK/genética
Ligante RANK/metabolismo
Receptores de Hormônios Paratireóideos/genética
Receptores de Hormônios Paratireóideos/metabolismo
Fatores de Transcrição SOX9/genética
Fatores de Transcrição SOX9/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Collagen Type II); 0 (Osteoprotegerin); 0 (Parathyroid Hormone-Related Protein); 0 (RANK Ligand); 0 (Receptors, Parathyroid Hormone); 0 (SOX9 Transcription Factor)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150128
[St] Status:MEDLINE
[do] DOI:10.3390/ijms16022663


  9 / 940 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:24877630
[Au] Autor:Ben-awadh AN; Delgado-Calle J; Tu X; Kuhlenschmidt K; Allen MR; Plotkin LI; Bellido T
[Ad] Endereço:Departments of Anatomy and Cell Biology (A.N.B., J.D.-C., X.T., K.K., M.R.A., L.I.P., T.B.) and Medicine (T.B.), Division of Endocrinology, Indiana University School of Medicine, and Roudebush Veterans Administration Medical Center (J.D.-C., L.I.P., T.B.), Indianapolis, Indiana 46202.
[Ti] Título:Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.
[So] Source:Endocrinology;155(8):2797-809, 2014 Aug.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PTH upregulates the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell responsible for RANKL-mediated stimulation of bone resorption remains undefined. We report that constitutive activation of PTH receptor signaling only in osteocytes in transgenic mice (DMP1-caPTHR1) was sufficient to increase Rankl expression and bone resorption. Resorption in DMP1-caPTHR1 mice crossed with mice lacking the distal control region regulated by PTH in the Rankl gene (DCR(-/-)) was similar to DMP1-caPTHR1 mice at 1 month of age, but progressively declined to reach values undistinguishable from wild-type (WT) mice at 5 months of age. Moreover, DMP1-caPTHR1 mice exhibited low tissue material density and increased serum alkaline phosphatase activity at 5 month of age, and these indices of high remodeling were partially and totally corrected in compound DMP1-caPTHR1;DCR(-/-) male mice, and less affected in female mice. Rankl expression in bones from DMP1-caPTHR1 mice was elevated at both 1 and 5 months of age, whereas it was high, similar to DMP1-caPTHR1 mice at 1 month, but low, similar to WT levels at 5 months in compound mice. Moreover, PTH increased Rankl and decreased Sost and Opg expression in ex vivo bone organ cultures established from WT mice, but only regulated Sost and Opg expression in cultures from DCR(-/-) mice. PTH also increased RANKL expression in osteocyte-containing primary cultures of calvarial cells, in isolated murine osteocytes, and in WT but not in DCR(-/-) osteocyte-enriched bones. Thus, PTH upregulates Rankl expression in osteocytes in vitro, ex vivo and in vivo, and resorption induced by PTH receptor signaling in the adult skeleton requires direct regulation of the Rankl gene in osteocytes.
[Mh] Termos MeSH primário: Reabsorção Óssea
Osteócitos/metabolismo
Hormônio Paratireóideo/metabolismo
Ligante RANK/genética
Receptores de Hormônios Paratireóideos/fisiologia
Transdução de Sinais/genética
[Mh] Termos MeSH secundário: Animais
Reabsorção Óssea/genética
Modelos Animais de Doenças
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Seres Humanos
Masculino
Camundongos
Camundongos Transgênicos
Técnicas de Cultura de Órgãos
Cultura Primária de Células
Ligante RANK/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, AMERICAN RECOVERY AND REINVESTMENT ACT; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Parathyroid Hormone); 0 (RANK Ligand); 0 (Receptors, Parathyroid Hormone); 0 (Tnfsf11 protein, mouse)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:140601
[St] Status:MEDLINE
[do] DOI:10.1210/en.2014-1046


  10 / 940 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:24712267
[Au] Autor:Krysiak R; Bartecka A; Okopien B
[Ti] Título:[Rare abnormalities of parathyroid gland function and parathyroid hormone receptor action].
[Ti] Título:Rzadkie zaburzenia funkcji przytarczyc i dzialania receptorowego parathormonu..
[So] Source:Przegl Lek;71(1):36-47, 2014.
[Is] ISSN:0033-2240
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:The parathyroid glands, located near or within the posterior surface of the thyroid gland and secreting parathyroid hormone, are essential organs for the regulation of calcium and phosphate metabolism. As they are necessary to sustain life and maintain homeostasis, undetected or misdiagnosed parathyroid disorders may pose a significant threat to health outcomes, as their presence may increase morbidity and mortality in affected individuals. The clinical picture of some disorders associated with abnormal parathyroid hormone secretion and receptor action is sometimes complicated by coexisting abnormalities, and in these cases establishing the correct diagnosis is challenging. The remarkable progress of recent years in the area of hormonal assessment, imaging procedures and molecular biology, has resulted in a great improvement in the identification, differentiation and treatment of various parathyroid disorders and has made it possible to identify several new clinical entities. In this paper, we discuss the present state-of-art on the etiopathogenesis, clinical manifestations, diagnosis and treatment of chosen rare abnormalities of parathyroid gland function and parathyroid hormone receptor action.
[Mh] Termos MeSH primário: Doenças das Paratireoides/diagnóstico
Doenças das Paratireoides/metabolismo
Glândulas Paratireoides/fisiopatologia
Receptores de Hormônios Paratireóideos/metabolismo
[Mh] Termos MeSH secundário: Cálcio/metabolismo
Seres Humanos
Doenças das Paratireoides/terapia
Neoplasias das Paratireoides/diagnóstico
Neoplasias das Paratireoides/metabolismo
Neoplasias das Paratireoides/terapia
Fosfatos/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phosphates); 0 (Receptors, Parathyroid Hormone); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140409
[Lr] Data última revisão:
140409
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140410
[St] Status:MEDLINE



página 1 de 94 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde