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Pesquisa : D12.776.543.750.695.862 [Categoria DeCS]
Referências encontradas : 956 [refinar]
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[PMID]:28364694
[Au] Autor:Pytka K; Mlyniec K; Podkowa K; Podkowa A; Jakubczyk M; Zmudzka E; Lustyk K; Sapa J; Filipek B
[Ad] Endereço:Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland. Electronic address: karolina.pytka@uj.edu.pl.
[Ti] Título:The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect.
[So] Source:Pharmacol Rep;69(3):546-554, 2017 Jun.
[Is] ISSN:1734-1140
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Over the last few decades, depression has become one of the major public health problems in our society. This problem is connected not only with morbidity, but also with treatment, specifically with the effectiveness of the therapy as well as the concomitant side effects of available antidepressants. Major depressive disorder is a complex clinical entity, including different molecular mechanisms and neurological processes. This complexity is a challenge for scientists seeking to discover an innovatory antidepressant drug with multiple and complementary mechanisms of action. In this review, we discuss the role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in depression and antidepressant-like effects.
[Mh] Termos MeSH primário: Antidepressivos/metabolismo
Transtorno Depressivo Maior/fisiopatologia
Desenho de Drogas
[Mh] Termos MeSH secundário: Animais
Antidepressivos/farmacologia
Transtorno Depressivo Maior/tratamento farmacológico
Seres Humanos
Melatonina/metabolismo
Receptores de Glucocorticoides/metabolismo
Receptores de Melatonina/metabolismo
Receptores de Taquicininas/metabolismo
Taquicininas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Receptors, Glucocorticoid); 0 (Receptors, Melatonin); 0 (Receptors, Tachykinin); 0 (Tachykinins); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE


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[PMID]:28131781
[Au] Autor:Mizoguchi H; Watanabe C; Hayashi T; Iwata Y; Watanabe H; Katsuyama S; Hamamura K; Sakurada T; Ohtsu H; Yanai K; Sakurada S
[Ad] Endereço:Department of Physiology and Anatomy, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
[Ti] Título:The involvement of spinal release of histamine on nociceptive behaviors induced by intrathecally administered spermine.
[So] Source:Eur J Pharmacol;800:9-15, 2017 Apr 05.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The involvement of spinal release of histamine on nociceptive behaviors induced by spermine was examined in mice. Intrathecal spermine produced dose-dependent nociceptive behaviors, consisting of scratching, biting and licking. The nociceptive behaviors induced by spermine at 0.02 amol and 10 pmol were markedly suppressed by i.t. pretreatment with antiserum against histamine and were abolished in histidine decarboxylase-deficient mice. In histamine H receptor-deficient mice, the nociceptive behaviors induced by spermine were completely abolished after treatment with 0.02 amol of spermine and significantly suppressed after treatment with 10 pmol of spermine. The i.t. pretreatment with takykinin NK receptor antagonists eliminated the nociceptive behaviors induced by 0.02 amol of spermine, but did not affect the nociceptive behaviors induced by 10 pmol of spermine. On the other hand, the nociceptive behaviors induced by spermine at both 0.02 amol and 10 pmol were suppressed by i.t. pretreatment with antagonists for the NMDA receptor polyamine-binding site. The present results suggest that the nociceptive behaviors induced by i.t. administration of spermine are mediated through the spinal release of histamine and are elicited via activation of NMDA receptors.
[Mh] Termos MeSH primário: Liberação de Histamina/efeitos dos fármacos
Nociceptividade/efeitos dos fármacos
Espermina/administração & dosagem
Espermina/farmacologia
Canal Vertebral
Medula Espinal/efeitos dos fármacos
Medula Espinal/secreção
[Mh] Termos MeSH secundário: Animais
Masculino
Camundongos
Receptores de N-Metil-D-Aspartato/metabolismo
Receptores de Taquicininas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, N-Methyl-D-Aspartate); 0 (Receptors, Tachykinin); 2FZ7Y3VOQX (Spermine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


  3 / 956 MEDLINE  
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[PMID]:27923683
[Au] Autor:Gui SH; Jiang HB; Xu L; Pei YX; Liu XQ; Smagghe G; Wang JJ
[Ad] Endereço:Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400715, China.
[Ti] Título:Role of a tachykinin-related peptide and its receptor in modulating the olfactory sensitivity in the oriental fruit fly, Bactrocera dorsalis (Hendel).
[So] Source:Insect Biochem Mol Biol;80:71-78, 2017 Jan.
[Is] ISSN:1879-0240
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Insect tachykinin-related peptide (TRP), an ortholog of tachykinin in vertebrates, has been linked with regulation of diverse physiological processes, such as olfactory perception, locomotion, aggression, lipid metabolism and myotropic activity. In this study, we investigated the function of TRP (BdTRP) and its receptor (BdTRPR) in an important agricultural pest, the oriental fruit fly Bactrocera dorsalis. BdTRPR is a typical G-protein coupled-receptor (GPCR), and it could be activated by the putative BdTRP mature peptides with the effective concentrations (EC ) at the nanomolar range when expressed in Chinese hamster ovary cells. Consistent with its role as a neuromodulator, expression of BdTRP was detected in the central nervous system (CNS) of B. dorsalis, specifically in the local interneurons with cell bodies lateral to the antennal lobe. BdTRPR was found in the CNS, midgut and hindgut, but interestingly also in the antennae. To investigate the role of BdTRP and BdTRPR in olfaction behavior, adult flies were subjected to RNA interference, which led to a reduction in the antennal electrophysiological response and sensitivity to ethyl acetate in the Y-tube assay. Taken together, we demonstrate the impact of TRP/TRPR signaling on the modulation of the olfactory sensitivity in B. dorsalis. The result improve our understanding of olfactory processing in this agriculturally important pest insect.
[Mh] Termos MeSH primário: Proteínas de Insetos/genética
Percepção Olfatória
Receptores de Taquicininas/genética
Taquicininas/genética
Tephritidae/fisiologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sequência de Bases
Células CHO
Clonagem Molecular
Cricetulus
DNA Complementar/genética
DNA Complementar/metabolismo
Proteínas de Insetos/química
Proteínas de Insetos/metabolismo
Filogenia
Interferência de RNA
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Receptores de Taquicininas/metabolismo
Alinhamento de Sequência
Taquicininas/química
Taquicininas/metabolismo
Tephritidae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (Insect Proteins); 0 (RNA, Messenger); 0 (Receptors, Tachykinin); 0 (Tachykinins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE


  4 / 956 MEDLINE  
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[PMID]:27919954
[Au] Autor:Obata K; Shimo T; Okui T; Matsumoto K; Takada H; Takabatake K; Kunisada Y; Ibaragi S; Nagatsuka H; Sasaki A
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Okayama, Japan.
[Ti] Título:Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma.
[So] Source:Anticancer Res;36(12):6335-6341, 2016 12.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown. MATERIALS AND METHODS: We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis. RESULTS: We found that even though the expression level of TACR3 was negative in the normal epithelium, it was highly elevated in tumor cells. A more intense signal was observed in the invasive front of tumor cells that had migrated into the mandible bone matrix. TAC3 was not detected in tumor cells, but was expressed in PGP-9.5-positive sensory nerves in the mandible. CONCLUSION: Our results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/metabolismo
Neoplasias Bucais/metabolismo
Receptores da Neurocinina-3/metabolismo
Receptores de Taquicininas/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Neurokinin-3); 0 (Receptors, Tachykinin); 0 (TACR3 protein, human)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE


  5 / 956 MEDLINE  
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[PMID]:27784644
[Au] Autor:Zhang J; He C; Pi X; Wang Y; Zhou L; Dong S
[Ad] Endereço:Institute of Biochemistry and Molecular Biology, School of Life Sciences, 222 Tianshui South Road, Lanzhou 730000, China.
[Ti] Título:MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH , regulates the depressor effects induced by endokinin A/B.
[So] Source:Eur J Pharmacol;792:33-37, 2016 Dec 05.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The interactions of the chimeric peptide MCRT (YPFPFRTic-NH ), based on morphiceptin and neuropeptide FF derivative PFRTic-NH , on the effects of endokinin A/B (EKA/B) on mean arterial blood pressure of the urethane-anaesthetized rat have been investigated in the absence and presence of tachykinin receptor antagonists, naloxone and NO synthase inhibitors. While MCRT produced dose dependent decreases in mean arterial pressure, in its presence only a small but statistically insignificant decreases in the magnitude and the time course of the depressor effect of EKA/B (10nmol/kg) were observed. MCRT had little influence on the depressor effect of EKA/B (1 nmol/kg), but strongly potentiated that of EKA/B (100nmol/kg). The tachykinin NK receptor antagonist SR140333B (1mg/kg) and the NK antagonist SR142891 (2.79mg/kg) both reduced the hypotensive effects of EKA/B and MCRT alone and blocked those of the two peptides in combination. The NK antagonist GR159897 (4mg/kg) partially blocked the depressor effects of EKA/B and MCRT alone. Naloxone (2mg/kg) completely blocked the depressor effect of MCTR, but partially blocked that of EKA/B. The NO synthase inhibitor l-NAME (50mg/kg) partially blocked the depressor effects of EKA/B, MCRT, and EKA/B + MCRT. These results could help to better understand the role of tachykinin receptors, opioid receptors and neuropeptide FF receptors in cardiovascular system.
[Mh] Termos MeSH primário: Sistema Cardiovascular/efeitos dos fármacos
Endorfinas/química
Endorfinas/farmacologia
Oligopeptídeos/química
Taquicininas/farmacologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Relação Dose-Resposta a Droga
Indóis/farmacologia
Masculino
Óxido Nítrico Sintase/antagonistas & inibidores
Piperidinas/farmacologia
Ratos
Ratos Wistar
Receptores de Neuropeptídeos/metabolismo
Receptores Opioides/metabolismo
Receptores de Taquicininas/antagonistas & inibidores
Tropanos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endorphins); 0 (GR 159897); 0 (Indoles); 0 (Oligopeptides); 0 (Piperidines); 0 (Receptors, Neuropeptide); 0 (Receptors, Opioid); 0 (Receptors, Tachykinin); 0 (SR 142801); 0 (SR140333B); 0 (Tachykinins); 0 (Tropanes); 0 (neuropeptide FF receptor); 97TZA8ANPC (morphiceptin); 99566-27-5 (phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide); EC 1.14.13.39 (Nitric Oxide Synthase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  6 / 956 MEDLINE  
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[PMID]:27636018
[Au] Autor:Skorupskaite K; George JT; Veldhuis JD; Millar RP; Anderson RA
[Ad] Endereço:MRC Centre for Reproductive Health (K.S., J.T.G., R.A.A.), The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom; Endocrine Research Unit (J.D.V.), Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota 55905; and Mammal Research
[Ti] Título:Interactions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women.
[So] Source:J Clin Endocrinol Metab;101(12):4628-4636, 2016 Dec.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Kisspeptin and neurokinin B (NKB) are obligate for normal gonadotropin secretion, but their hierarchy is unexplored in normal women. OBJECTIVE: To investigate the interaction between kisspeptin and NKB on estrogen-regulated LH secretion. DESIGN: Women were treated with neurokinin-3 receptor (NK3R) antagonist followed by transdermal estradiol to induce LH secretion 48 hours later, with kisspeptin-10 or vehicle infusion during estrogen administration in a 2-way crossover study. SETTING: Clinical research facility. PATIENTS OR OTHER PARTICIPANTS: Healthy females with regular menses. INTERVENTION(S): NK3R antagonist AZD4901 40 mg twice daily orally was taken from cycle day 4-6 for 6 days (n = 10, with 10 no treatment controls). Transdermal estradiol patches (200 µg/d) were applied after 5 days of NK3R antagonist treatment. At 24-hour estradiol treatment, women were randomized to 7-hour kisspeptin-10 (4 µg/kg/h) or vehicle iv infusion, with the alternate infusion in a subsequent cycle. MAIN OUTCOME MEASURE(S): Plasma gonadotropin and estradiol secretion. RESULTS: After an initial suppression, LH secretion was increased 48 hours after estradiol treatment. Kisspeptin-10 increased LH secretion during the inhibitory phase, and LH remained elevated beyond the discontinuation of kisspeptin-10 infusion. NK3R antagonist decreased LH pulse frequency (0.5 ± 0.2 vs 0.7 ± 0.2 pulses/h, P < .05) and stimulated FSH response to kisspeptin-10 infusion (10.7 ± 11.0 vs 5.0 ± 3.6 IU/L, P < .05) with a nonsignificant rise in LH. The duration of LH response was blunted, with LH being lower at 48 hours (7.5 ± 4.8 vs 15.0 ± 11.4 IU/L, P < .05). CONCLUSIONS: These data demonstrate that NKB signaling regulates GnRH/LH secretion in normal women, and is predominantly proximal to kisspeptin in mediating estrogenic positive and negative feedback on LH secretion.
[Mh] Termos MeSH primário: Estradiol/farmacologia
Estrogênios/farmacologia
Retroalimentação Fisiológica/fisiologia
Kisspeptinas/farmacologia
Hormônio Luteinizante/metabolismo
Neurocinina B/metabolismo
Neurotransmissores/farmacologia
Receptores de Taquicininas/antagonistas & inibidores
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos Cross-Over
Estradiol/administração & dosagem
Estrogênios/administração & dosagem
Feminino
Seres Humanos
Kisspeptinas/administração & dosagem
Meia-Idade
Neurotransmissores/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Estrogens); 0 (KISS1 protein, human); 0 (Kisspeptins); 0 (Neurotransmitter Agents); 0 (Receptors, Tachykinin); 0 (neurokinin receptor 4); 4TI98Z838E (Estradiol); 86933-75-7 (Neurokinin B); 9002-67-9 (Luteinizing Hormone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE


  7 / 956 MEDLINE  
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[PMID]:27609608
[Au] Autor:Bayati S; Bashash D; Ahmadian S; Safaroghli-Azar A; Alimoghaddam K; Ghavamzadeh A; Ghaffari SH
[Ad] Endereço:Institute of Biochemistry and Biophysics, University of Tehran, P.O. Box 13145-1384, Tehran, Iran; Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:Inhibition of tachykinin NK receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells.
[So] Source:Eur J Pharmacol;791:274-283, 2016 Nov 15.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Increasing number of genetic and cancer biology studies indicated a prominent role for tachykinin NK receptor (NK R) in cancer cell growth and survival. Considering the fact that neoplastic lymphoid precursors in acute lymphoblastic leukemia (ALL) carry a three- to four-fold NK R expression as compared to normal lymphocytes, using NK R antagonist seems to be noteworthy in the treatment of ALL patients. In this study, we found that inhibition of NK R with aprepitant, a selective high-affinity antagonist of the human NK R, exerts cytotoxic and anti-proliferative effects against pre-B ALL-derived Nalm-6 cells either as single drug or in combination with doxorubicin. Our data showed that treatment of the cells with the inhibitor resulted in apoptotic cell death, at least partly, through abrogation of PI3K/Akt pathway, as revealed by the reduction of phospho/total Akt ratio. In agreement with the inhibitory effect on Akt, we also found that aprepitant increased the expression level of p21 and p27, which in turn leads to the induction of G1 cell cycle arrest. Overall, this study recommends mechanistic pathways by which inhibition of NK R can augment apoptotic cell death through a plausible p53-dependent pathway rather than NF-κB-depended mechanism in pre-B ALL cells; however, further studies are needed to better characterize the application of NK R inhibition in clinical cancer treatment.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos
Morfolinas/farmacologia
Leucemia-Linfoma Linfoblástico de Células Precursoras B/patologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Receptores de Taquicininas/antagonistas & inibidores
Proteína Supressora de Tumor p53/metabolismo
[Mh] Termos MeSH secundário: Caspase 3/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Doxorrubicina/farmacologia
Sinergismo Farmacológico
Ativação Enzimática/efeitos dos fármacos
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Fosfoproteínas/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Morpholines); 0 (Phosphoproteins); 0 (Reactive Oxygen Species); 0 (Receptors, Tachykinin); 0 (Tumor Suppressor Protein p53); 1NF15YR6UY (aprepitant); 80168379AG (Doxorubicin); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE


  8 / 956 MEDLINE  
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[PMID]:27146034
[Au] Autor:García-Ortega J; Pinto FM; Prados N; Bello AR; Almeida TA; Fernández-Sánchez M; Candenas L
[Ad] Endereço:Instituto Valenciano de Infertilidad, Sevilla, Spain.
[Ti] Título:Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.
[So] Source:Biol Reprod;94(6):124, 2016 Jun.
[Is] ISSN:1529-7268
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The neurokinin B/NK3 receptor (NK3R) and kisspeptin/kisspeptin receptor (KISS1R), two systems which are essential for reproduction, are coexpressed in human mural granulosa (MGC) and cumulus cells (CCs). However, little is known about the presence of other members of the tachykinin family in the human ovary. In the present study, we analyzed the expression of substance P (SP), hemokinin-1 (HK-1), NK1 receptor (NK1R), and NK2 receptor (NK2R) in MGCs and CCs collected from preovulatory follicles of oocyte donors at the time of oocyte retrieval. RT-PCR, quantitative RT-PCR, immunocytochemistry, and Western blotting were used to investigate the patterns of expression of tachykinin and tachykinin receptor mRNAs and proteins and the possible interaction between the tachykinin family and kisspeptin. Intracellular free Ca(2+) levels ([Ca(2+)]i) in MGCs after exposure to SP or kisspeptin in the presence of SP were also measured. We found that SP, HK-1, the truncated NK1R isoform NK1R-Tr, and NK2R were all expressed in MGCs and CCs. NK1R-Tr mRNA and NK2R mRNA and protein levels were higher in MGCs than in CCs from the same patients. Treatment of cells with kisspeptin modulated the expression of HK-1, NK3R, and KISS1R mRNAs, whereas treatment with SP regulated kisspeptin mRNA levels and reduced the [Ca(2+)]i response produced by kisspeptin. These data demonstrate that the whole tachykinin system is expressed and acts in coordination with kisspeptin to regulate granulosa cell function in the human ovary.
[Mh] Termos MeSH primário: Células do Cúmulo/metabolismo
Células da Granulosa/metabolismo
Kisspeptinas/metabolismo
Receptores de Taquicininas/metabolismo
Taquicininas/metabolismo
[Mh] Termos MeSH secundário: Cálcio/metabolismo
Células Cultivadas
Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Kisspeptins); 0 (Receptors, Tachykinin); 0 (Tachykinins); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1095/biolreprod.116.139881


  9 / 956 MEDLINE  
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[PMID]:26852958
[Au] Autor:Zhang K; Chen QT; Li JH; Geng X; Liu JF; Li HF; Feng Y; Li JL; Drew PA
[Ad] Endereço:Surgical Department, Affiliated Hospital of Hebei University, 212 Yuhua East Road, Baoding, Hebei Province 071000, China; Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei Province 050011, China.
[Ti] Título:The expression of tachykinin receptors in the human lower esophageal sphincter.
[So] Source:Eur J Pharmacol;774:144-9, 2016 Mar 05.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mammalian tachykinins are a family of neuropeptides which are potent modulators of smooth muscle function with a significant contractile effect on human smooth muscle preparations. Tachykinins act via three distinct G protein-coupled neurokinin (NK) receptors, NK1, NK2 and NK3, coded by the genes TACR1, TACR2 and TACR3 respectively. The purpose of this paper was to measure the mRNA and protein expression of these receptors and their isoforms in the clasp and sling fibers of the human lower esophageal sphincter complex and circular muscle from the adjacent distal esophagus and proximal stomach. We found differences in expression between the different receptors within these muscle types, but the rank order of the receptor expression did not differ between the different muscle types. The rank order of the mRNA expression was TACR2 (α isoform)>TACR2 (ß isoform)>TACR1 (short isoform)>TACR1 (long isoform)>TACR3. The rank order of the protein expression was NK2>NK1>NK3. This is the first report of the measurement of the transcript and protein expression of the tachykinin receptors and their isoforms in the muscles of the human lower esophageal sphincter complex. The results provide evidence that the tachykinin receptors could contribute to the regulation of the human lower esophageal sphincter, particularly the TACR2 α isoform which encodes the functional isoform of the tachykinin NK2 receptor was the most highly expressed of the tachykinin receptors in the muscles associated with the lower esophageal sphincter.
[Mh] Termos MeSH primário: Esfíncter Esofágico Inferior/metabolismo
Regulação da Expressão Gênica
Receptores de Taquicininas/genética
Receptores de Taquicininas/metabolismo
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Taquicininas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Receptors, Tachykinin); 0 (Tachykinins)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160209
[St] Status:MEDLINE


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[PMID]:26157068
[Au] Autor:Pinto FM; Bello AR; Gallardo-Castro M; Valladares F; Almeida TA; Tena-Sempere M; Candenas L
[Ad] Endereço:Instituto de Investigaciones Químicas, CSIC, Sevilla, Spain.
[Ti] Título:Analysis of the Expression of Tachykinins and Tachykinin Receptors in the Rat Uterus During Early Pregnancy.
[So] Source:Biol Reprod;93(2):51, 2015 Aug.
[Is] ISSN:1529-7268
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The peptides of the tachykinin family participate in the regulation of reproductive function acting at both central and peripheral levels. Our previous data showed that treatment of rats with a tachykinin NK3R antagonist caused a reduction of litter size. In the present study, we analyzed the expression of tachykinins and tachykinin receptors in the rat uterus during early pregnancy. Uterine samples were obtained from early pregnant rats (Days 1-9 of pregnancy) and from nonpregnant rats during the proestrus stage of the ovarian cycle, and real-time quantitative RT-PCR, immunohistochemistry, and Western blot studies were used to investigate the pattern of expression of tachykinins and tachykinin receptors. We found that all tachykinins and tachykinin receptors were locally synthesized in the uterus of early pregnant rats. The expression of substance P, neurokinin B, and the tachykinin receptors NK1R and NK3R mRNAs and proteins underwent major changes during the days around implantation and they were widely distributed in implantation sites, being particularly abundant in decidual cells. These findings support the involvement of the tachykinin system in the series of uterine events that occur around embryo implantation in the rat.
[Mh] Termos MeSH primário: Receptores de Taquicininas/biossíntese
Taquicininas/biossíntese
Útero/metabolismo
[Mh] Termos MeSH secundário: Animais
Decídua/citologia
Decídua/metabolismo
Implantação do Embrião/efeitos dos fármacos
Feminino
Tamanho da Ninhada de Vivíparos/efeitos dos fármacos
Neurocinina B/biossíntese
Gravidez
Proestro
Ratos
Ratos Wistar
Receptores da Neurocinina-1/biossíntese
Receptores da Neurocinina-2/antagonistas & inibidores
Receptores da Neurocinina-2/biossíntese
Receptores de Taquicininas/antagonistas & inibidores
Substância P/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Neurokinin-1); 0 (Receptors, Neurokinin-2); 0 (Receptors, Tachykinin); 0 (Tachykinins); 33507-63-0 (Substance P); 86933-75-7 (Neurokinin B)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150828
[Lr] Data última revisão:
150828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150710
[St] Status:MEDLINE
[do] DOI:10.1095/biolreprod.115.130617



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