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[PMID]:28468967
[Au] Autor:Keller B; Stumpf I; Strohmeier V; Usadel S; Verhoeyen E; Eibel H; Warnatz K
[Ad] Endereço:Center for Chronic Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
[Ti] Título:High SYK Expression Drives Constitutive Activation of CD21 B Cells.
[So] Source:J Immunol;198(11):4285-4292, 2017 06 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human CD21 B cells present with an activated phenotype and accumulate in distinct disorders connected with chronic immune stimulation. Signaling studies had revealed an increased basal phosphorylation of spleen tyrosine kinase (SYK) and phospholipase Cγ2. Additional BCR stimulation of these constitutively active cells, however, led to reduced activation of these signaling molecules and subsequently NF-κB and Ca activation. In this article, we demonstrate that high SYK expression is a common feature of CD21 B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase and phospholipase Cγ2. Inhibition of SYK activity eliminated features of the constitutive activation in these cells and partly restored BCR signaling. High SYK expression is especially induced by CpG or CD40L in combination with IL-21, but not BCR stimulation, suggesting the importance of the immune-stimulatory context for the induction of this B cell phenotype. In summary, high SYK expression is a common feature of human CD21 B cells and presumably results from chronic activation in inflammatory environments present in a subgroup of patients with heterogeneous disorders like chronic infection, autoimmunity, and immunodeficiency. High SYK expression by itself drives the constitutive activation observed in these B cells, which in turn may contribute to the hyporesponsiveness upon BCR stimulation. Given the high prevalence of autoreactive clones among CD21 B cells in autoimmune disorders, the dominant role of SYK in CD21 B cells may provide a new option for therapeutic interventions in patients with expanded CD21 B cells and humoral autoimmunity.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Ativação Linfocitária
Receptores de Complemento 3d/imunologia
Quinase Syk/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Linfócitos B/fisiologia
Ligante de CD40/imunologia
Feminino
Seres Humanos
Interleucinas/farmacologia
Masculino
Meia-Idade
Oligodesoxirribonucleotídeos/imunologia
Fosfolipase C gama/metabolismo
Fosforilação
Proteínas Tirosina Quinases/metabolismo
Receptores de Antígenos de Linfócitos B/imunologia
Transdução de Sinais
Quinase Syk/antagonistas & inibidores
Quinase Syk/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CPG-oligonucleotide); 0 (Interleukins); 0 (Oligodeoxyribonucleotides); 0 (Receptors, Antigen, B-Cell); 0 (Receptors, Complement 3d); 0 (interleukin-21); 147205-72-9 (CD40 Ligand); EC 2.7.10.1 (Agammaglobulinaemia tyrosine kinase); EC 2.7.10.1 (Protein-Tyrosine Kinases); EC 2.7.10.2 (SYK protein, human); EC 2.7.10.2 (Syk Kinase); EC 3.1.4.3 (Phospholipase C gamma)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180127
[Lr] Data última revisão:
180127
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700079


  2 / 1210 MEDLINE  
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[PMID]:28624043
[Au] Autor:Gorter RR; Wassenaar ECE; de Boer OJ; Bakx R; Roelofs JJTH; Bunders MJ; van Heurn LWE; Heij HA
[Ad] Endereço:Department of Paediatric Surgery, Paediatric Surgical Centre of Amsterdam, Emma Children's Hospital AMC and VU University Medical Centre, Amsterdam, The Netherlands. Electronic address: rr.gorter@vumc.nl.
[Ti] Título:Composition of the cellular infiltrate in patients with simple and complex appendicitis.
[So] Source:J Surg Res;214:190-196, 2017 Jun 15.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is now well established that there are two types of appendicitis: simple (nonperforating) and complex (perforating). This study evaluates differences in the composition of the immune cellular infiltrate in children with simple and complex appendicitis. MATERIALS AND METHODS: A total of 47 consecutive children undergoing appendectomy for acute appendicitis between January 2011 and December 2012 were included. Intraoperative criteria were used to identify patients with either simple or complex appendicitis and were confirmed histopathologically. Immune histochemical techniques were used to identify immune cell markers in the appendiceal specimens. Digital imaging analysis was performed using Image J. RESULTS: In the specimens of patients with complex appendicitis, significantly more myeloperoxidase positive cells (neutrophils) (8.7% versus 1.2%, P < 0.001) were detected compared to patients with a simple appendicitis. In contrast, fewer CD8+ T cells (0.4% versus 1.3%, P = 0.016), CD20 + cells (2.9% versus 9.0%, P = 0.027), and CD21 + cells (0.2% versus 0.6%, P = 0.028) were present in tissue from patients with complex compared to simple appendicitis. CONCLUSIONS: The increase in proinflammatory innate cells and decrease of adaptive cells in patients with complex appendicitis suggest potential aggravating processes in complex appendicitis. Further research into the underlying mechanisms may identify novel biomarkers to be able to differentiate simple and complex appendicitis.
[Mh] Termos MeSH primário: Apendicite/imunologia
Apêndice/imunologia
Linfócitos T CD8-Positivos/metabolismo
Neutrófilos/metabolismo
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Antígenos CD20/metabolismo
Apendicectomia
Apendicite/diagnóstico
Apendicite/cirurgia
Biomarcadores/metabolismo
Criança
Pré-Escolar
Diagnóstico Diferencial
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Fenótipo
Receptores de Complemento 3d/metabolismo
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD20); 0 (Biomarkers); 0 (Receptors, Complement 3d)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170619
[St] Status:MEDLINE


  3 / 1210 MEDLINE  
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[PMID]:28554574
[Au] Autor:Zhang L; Yang C; Lewis JS; El-Mofty SK; Chernock RD
[Ad] Endereço:Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
[Ti] Título:p16 expression in follicular dendritic cell sarcoma: a potential mimicker of human papillomavirus-related oropharyngeal squamous cell carcinoma.
[So] Source:Hum Pathol;66:40-47, 2017 Aug.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm that most commonly occurs in cervical lymph nodes. It has histologic and clinical overlap with the much more common p16-positive human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx, which characteristically has nonkeratinizing morphology and often presents as an isolated neck mass. Not surprisingly, follicular dendritic cell sarcomas are commonly misdiagnosed as squamous cell carcinoma. Immunohistochemistry is helpful in separating the 2 entities. Follicular dendritic cell sarcoma expresses dendritic markers such as CD21 and CD23 and is almost always cytokeratin negative. However, in many cases of HPV-related oropharyngeal carcinoma, only p16 immunohistochemistry as a prognostic and surrogate marker for HPV is performed. p16 expression in follicular dendritic cell sarcoma has not been characterized. Here, we investigate the expression of p16 in follicular dendritic cell sarcoma and correlate it with retinoblastoma protein expression. A pilot study of dendritic marker expression in HPV-related oropharyngeal squamous cell carcinoma was also performed. We found that 4 of 8 sarcomas expressed p16 with strong and diffuse staining in 2 cases. In 2 of the 4 cases, p16 expression corresponded to loss of retinoblastoma protein expression. Dendritic marker expression (CD21 and CD23) was not found in HPV-related oropharyngeal squamous cell carcinomas. As such, positive p16 immunohistochemistry cannot be used as supportive evidence for the diagnosis of squamous cell carcinoma as strong and diffuse p16 expression may also occur in follicular dendritic cell sarcoma. Cytokeratins and dendritic markers are critical in separating the two tumor types.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Carcinoma de Células Escamosas/química
Inibidor p16 de Quinase Dependente de Ciclina/análise
Sarcoma de Células Dendríticas Foliculares/metabolismo
Neoplasias de Cabeça e Pescoço/química
Neoplasias Orofaríngeas/química
Infecções por Papillomavirus/metabolismo
[Mh] Termos MeSH secundário: Adulto
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/virologia
Sarcoma de Células Dendríticas Foliculares/patologia
Diagnóstico Diferencial
Feminino
Neoplasias de Cabeça e Pescoço/patologia
Neoplasias de Cabeça e Pescoço/virologia
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Missouri
Neoplasias Orofaríngeas/patologia
Neoplasias Orofaríngeas/virologia
Infecções por Papillomavirus/patologia
Infecções por Papillomavirus/virologia
Projetos Piloto
Valor Preditivo dos Testes
Receptores de Complemento 3d/análise
Receptores de IgE/análise
Proteína do Retinoblastoma/análise
Tennessee
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Cyclin-Dependent Kinase Inhibitor p16); 0 (P16 protein, human); 0 (Receptors, Complement 3d); 0 (Receptors, IgE); 0 (Retinoblastoma Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


  4 / 1210 MEDLINE  
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[PMID]:28507081
[Au] Autor:Del Padre M; Todi L; Mitrevski M; Marrapodi R; Colantuono S; Fiorilli M; Casato M; Visentini M
[Ad] Endereço:Department of Clinical Medicine, Sapienza University of Rome Medical School, Rome, Italy.
[Ti] Título:Reversion of anergy signatures in clonal CD21 B cells of mixed cryoglobulinemia after clearance of HCV viremia.
[So] Source:Blood;130(1):35-38, 2017 Jul 06.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of IgM CD27 B cells. These cells display both the features of anergy induced by continual engagement of the B-cell receptor (BCR), such as high expression of phosphorylated extracellular signal-regulated kinase (pERK) and reduced lifespan, and of virus-specific exhaustion, such as CD21 phenotype and a defective response to ligation of BCR and Toll-like receptor 9 (TLR9). MC usually regresses after eradication of HCV with interferon, whose immunomodulatory activity might contribute to this effect. We investigated the phenotypic and functional changes in clonal B cells of MC patients with sustained virologic responses to direct-acting antivirals (DAAs), which lack immunomodulatory properties. We found that high pERK expression and accelerated apoptosis revert within 4 weeks after beginning therapy, whereas clonal B cells unresponsive to TLR9 stimulation persist for at least 24 weeks, although they may partially rescue normal CD21 expression. Thus, similar to mouse models, features of anergy in MC B cells rapidly revert after disengagement from HCV, whereas virus-specific exhaustion imparts a durable inhibitory imprint on cell function. Treatment of HCV MC with DAAs provides a valuable tool for untangling the molecular mechanisms of anergy and exhaustion in human B cells.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Anergia Clonal
Crioglobulinemia/imunologia
Hepacivirus/imunologia
Hepatite C/imunologia
Receptores de Complemento 3d/imunologia
Viremia/imunologia
[Mh] Termos MeSH secundário: Crioglobulinemia/etiologia
Feminino
Regulação da Expressão Gênica/imunologia
Hepatite C/terapia
Seres Humanos
Masculino
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Complement 3d)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2017-03-771238


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[PMID]:28288791
[Au] Autor:Saadoun D; Pol S; Ferfar Y; Alric L; Hezode C; Si Ahmed SN; de Saint Martin L; Comarmond C; Bouyer AS; Musset L; Poynard T; Resche Rigon M; Cacoub P
[Ad] Endereço:Sorbonne Universités, Université Pierre et Marie Curie University of Paris 06, Unité Médicale de Recherche 7211, Inflammation-Immunopathology-Biotherapy Department (Département Hospitalo Universitaire Inflammation, Immunopathology and Biotherapy), Paris, France; INSERM, Unité Médicale de Recherche_S
[Ti] Título:Efficacy and Safety of Sofosbuvir Plus Daclatasvir for Treatment of HCV-Associated Cryoglobulinemia Vasculitis.
[So] Source:Gastroenterology;153(1):49-52.e5, 2017 Jul.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Circulating mixed cryoglobulins are detected in 40%-60% of patients with hepatitis C virus (HCV) infection, and overt cryoglobulinemia vasculitis (CryoVas) develops in approximately 15% of patients. Remission of vasculitis has been associated with viral clearance, but few studies have reported the effectiveness of direct-acting antiviral drugs in these patients. We performed an open-label, prospective, multicenter study of the effectiveness and tolerance of an all-oral, interferon- and ribavirin-free regimen of sofosbuvir plus daclatasvir in patients with HCV-associated CryoVas. Forty-one consecutive patients with active HCV-associated CryoVas (median age, 56 y; 53.6% women) were recruited from hospitals in Paris, France, from 2014 through 2016. They received sofosbuvir (400 mg/day) plus daclatasvir (60 mg/day) for 12 weeks (n = 32) or 24 weeks (n = 9), and were evaluated every 4 weeks until week 24 and at week 36. Blood samples were analyzed for complete blood count, serum chemistry profile, level of alanine aminotransferase, rheumatoid factor activity, C4 fraction of complement, and cryoglobulin; peripheral blood mononuclear cells were isolated for flow cytometry analysis. Thirty-seven patients (90.2%) had a complete clinical response (defined by improvement of all the affected organs involved at baseline and no clinical relapse) after a median time of 12 weeks of therapy; all had a sustained virologic response (no detectable serum HCV RNA 12 weeks after the end of antiviral therapy). Patients' mean cryoglobulin level decreased from 0.56 ± 0.18 at baseline to 0.21 ± 0.14 g/L at week 36, and no cryoglobulin was detected in 50% of patients at this time point. After antiviral therapy, patients had increased numbers of T-regulatory cells, IgM+CD21-/low-memory B cells, CD4+CXCR5+ interleukin 21+ cells, and T-helper 17 cells, compared with before therapy. After a median follow-up period of 26 months (interquartile range, 20-30 mo), no patients had a serious adverse event or relapse of vasculitis.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Crioglobulinemia/tratamento farmacológico
Crioglobulinas/metabolismo
Hepatite C/tratamento farmacológico
Imidazóis/uso terapêutico
Sofosbuvir/uso terapêutico
Vasculite/tratamento farmacológico
[Mh] Termos MeSH secundário: Antivirais/efeitos adversos
Linfócitos B/química
Linfócitos T CD4-Positivos/química
Crioglobulinemia/sangue
Crioglobulinemia/virologia
Quimioterapia Combinada
Feminino
Hepatite C/sangue
Hepatite C/complicações
Seres Humanos
Imidazóis/efeitos adversos
Imunoglobulina M/análise
Interleucinas/análise
Contagem de Linfócitos
Masculino
Meia-Idade
Estudos Prospectivos
Receptores CXCR5/análise
Receptores de Complemento 3d/análise
Sofosbuvir/efeitos adversos
Resposta Viral Sustentada
Linfócitos T Reguladores
Células Th17
Vasculite/sangue
Vasculite/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (BMS-790052); 0 (CXCR5 protein, human); 0 (Cryoglobulins); 0 (Imidazoles); 0 (Immunoglobulin M); 0 (Interleukins); 0 (Receptors, CXCR5); 0 (Receptors, Complement 3d); 0 (interleukin-21); WJ6CA3ZU8B (Sofosbuvir)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


  6 / 1210 MEDLINE  
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[PMID]:28239083
[Au] Autor:Pyeon SI; Song GA; Baek DH; Kim GH; Lee BE; Lee SJ; Yoon JB; Han SY; Park DY
[Ad] Endereço:Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
[Ti] Título:Primary Follicular Lymphoma in the Rectum Incidentally Found on Screening Colonoscopy.
[So] Source:Korean J Gastroenterol;69(2):139-142, 2017 Feb 25.
[Is] ISSN:2233-6869
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:The gastrointestinal tract is the most common site of extra-nodal non-Hodgkin lymphoma. However, the incidence of primary rectal lymphoma is extremely rare. Among the primary gastrointestinal lymphomas, follicular lymphoma has been described as a rare disease. It is difficult to diagnose rectal lymphoma due to its variable growth patterns and inadequate biopsies. Majority of patients with rectal lymphoma have non-specific symptoms or negative biopsies, often delaying the diagnosis. Our patient is a 62-year-old female. Two sessile and smooth subepithelial lesions with a yellowish normal mucosa were found on a screening colonoscopy. The initial mucosal biopsy finding was chronic inflammation, but we were highly suspicion of malignancy; we performed an endoscopic mucosal resection. Herein, we present a rare case of rectal follicular lymphoma diagnosed by endoscopic mucosal resection with a literature review.
[Mh] Termos MeSH primário: Linfoma Folicular/diagnóstico
[Mh] Termos MeSH secundário: Colonoscopia
Feminino
Seres Humanos
Imuno-Histoquímica
Mucosa Intestinal/patologia
Linfoma Folicular/patologia
Meia-Idade
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Receptores de Complemento 3d/metabolismo
Reto/patologia
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Receptors, Complement 3d)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.4166/kjg.2017.69.2.139


  7 / 1210 MEDLINE  
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[PMID]:28193736
[Au] Autor:Kim ES; Ackermann C; Tóth I; Dierks P; Eberhard JM; Wroblewski R; Scherg F; Geyer M; Schmidt RE; Beisel C; Bockhorn M; Haag F; van Lunzen J; Schulze Zur Wiesch J
[Ad] Endereço:I. Department of Medicine, Section of Infectious Diseases, University Medical Center Hamburg-Eppendorf, Eppendorf, Germany.
[Ti] Título:Down-regulation of CD73 on B cells of patients with viremic HIV correlates with B cell activation and disease progression.
[So] Source:J Leukoc Biol;101(5):1263-1271, 2017 May.
[Is] ISSN:1938-3673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recently, alterations of the T cell expression of the ectonucleotidases, CD39 and CD73, during HIV infection have been described. Here, peripheral ( = 70) and lymph nodal B cells ( = 10) of patients with HIV at different stages of disease as well as uninfected individuals were analyzed via multicolor flow cytometry with regard to expression of CD39 and CD73 and differentiation, proliferation, and exhaustion status. Patients with chronic, untreated HIV showed a significantly decreased frequency of CD73-expressing B cells ( < 0.001) compared with healthy controls. Decreased frequencies of CD39 CD73 B cells in patients with HIV correlated with low CD4 counts ( < 0.0256) as well as increased proliferation and exhaustion status as determined by Ki-67 and programmed death-1 expression. Down-regulation of CD73 was observed in naive and memory B cells as determined by CD27 and CD21. Neither HIV elite controller patients nor antiretroviral therapy-treated patients had significantly lower CD39 and CD73 expression on B cells compared with healthy controls. Of importance, low CD73 expression on B cells was associated with modulated in vitro B cell function. Further in vivo studies are warranted to evaluate the in vivo role of phenotypic loss of CD73 in B cell dysregulation in HIV.
[Mh] Termos MeSH primário: 5´-Nucleotidase/imunologia
Linfócitos B/imunologia
Regulação da Expressão Gênica/imunologia
Infecções por HIV/imunologia
Viremia/imunologia
[Mh] Termos MeSH secundário: 5'-Nucleotidase/genética
Adulto
Idoso
Idoso de 80 Anos ou mais
Fármacos Anti-HIV/uso terapêutico
Antígenos CD/genética
Antígenos CD/imunologia
Apirase/genética
Apirase/imunologia
Linfócitos B/efeitos dos fármacos
Linfócitos B/patologia
Linfócitos B/virologia
Contagem de Linfócito CD4
Estudos de Casos e Controles
Diferenciação Celular
Proliferação Celular
Progressão da Doença
Feminino
Proteínas Ligadas por GPI/genética
Proteínas Ligadas por GPI/imunologia
Infecções por HIV/tratamento farmacológico
Infecções por HIV/patologia
Infecções por HIV/virologia
Seres Humanos
Memória Imunológica
Antígeno Ki-67/genética
Antígeno Ki-67/imunologia
Linfonodos/efeitos dos fármacos
Linfonodos/imunologia
Linfonodos/patologia
Linfonodos/virologia
Ativação Linfocitária
Masculino
Meia-Idade
Receptor de Morte Celular Programada 1/genética
Receptor de Morte Celular Programada 1/imunologia
Receptores de Complemento 3d/genética
Receptores de Complemento 3d/imunologia
Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/genética
Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia
Viremia/tratamento farmacológico
Viremia/patologia
Viremia/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Antigens, CD); 0 (GPI-Linked Proteins); 0 (Ki-67 Antigen); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 0 (Receptors, Complement 3d); 0 (Tumor Necrosis Factor Receptor Superfamily, Member 7); EC 3.1.3.5 (5'-Nucleotidase); EC 3.1.3.5 (NT5E protein, human); EC 3.6.1.5 (Apyrase); EC 3.6.1.5 (CD39 antigen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1189/jlb.5A0816-346R


  8 / 1210 MEDLINE  
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[PMID]:28190261
[Au] Autor:Meng QH; White HN
[Ad] Endereço:Molecular Immunology Unit, Institute of Child Health, University College London, London, UK.
[Ti] Título:CD21 CD23 follicular B cells express antigen-specific secretory IgM mRNA as primary and memory responses.
[So] Source:Immunology;151(2):211-218, 2017 Jun.
[Is] ISSN:1365-2567
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CD21 CD23 IgM mouse follicular B cells comprise the bulk of the mature B-cell compartment, but it is not known whether these cells contribute to the humoral antibody response. We show using a direct RT-PCR method for antigen-specific VH, that FACS-sorted mouse CD21 CD23 B cells express specific secretory IgM VH transcripts in response to immunization and also exhibit a memory response. The secretory IgM expressed is distinct from the IgG expressed by cells of this phenotype, which we also analyse here, having a distinct broader distribution of CDR-H3 sequences and zero or low levels of somatic mutation in the region analysed. These results imply that cells of the CD21 CD23 phenotype have distinct IgM and IgG populations that contribute directly to the humoral antibody and memory responses by expressing antigen-specific secretory immunoglobulin. We also argue that the more diverse CDR-H3 sequences expressed by antigen-experienced IgM CD21 CD23 follicular B cells would place them at the bottom of a recently hypothesized memory B-cell hierarchy.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Linfócitos B/metabolismo
Imunoglobulina M/genética
RNA Mensageiro/genética
Receptores de Complemento 3d/imunologia
Receptores de IgE/imunologia
[Mh] Termos MeSH secundário: Animais
Feminino
Imunoglobulina M/imunologia
Memória Imunológica/genética
Memória Imunológica/imunologia
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin M); 0 (RNA, Messenger); 0 (Receptors, Complement 3d); 0 (Receptors, IgE)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE
[do] DOI:10.1111/imm.12724


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[PMID]:28119289
[Au] Autor:Alivernini S; Tolusso B; Petricca L; Bui L; Di Sante G; Peluso G; Benvenuto R; Fedele AL; Federico F; Ferraccioli G; Gremese E
[Ad] Endereço:Institute of Rheumatology, Fondazione Policlinico Universitario Agostino Gemelli, Catholic University of the Sacred Heart, Rome, Italy.
[Ti] Título:Synovial features of patients with rheumatoid arthritis and psoriatic arthritis in clinical and ultrasound remission differ under anti-TNF therapy: a clue to interpret different chances of relapse after clinical remission?
[So] Source:Ann Rheum Dis;76(7):1228-1236, 2017 Jul.
[Is] ISSN:1468-2060
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To define the synovial characteristics of patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) in clinical and ultrasound remission achieved by combination therapy with methotrexate (MTX) and tumour necrosis factor (TNF) blockers. METHODS: Patients with RA in remission (n=25) (disease activity score (DAS)<1.6 for at least 6 months), patients with RA in low disease activity (LDA) (n=10) (1.6
[Mh] Termos MeSH primário: Adalimumab/uso terapêutico
Antirreumáticos/uso terapêutico
Artrite Psoriásica/tratamento farmacológico
Artrite Reumatoide/tratamento farmacológico
Etanercepte/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Antígenos CD/metabolismo
Antígenos CD20/metabolismo
Antígenos de Diferenciação Mielomonocítica/metabolismo
Artrite Psoriásica/diagnóstico por imagem
Artrite Psoriásica/metabolismo
Artrite Psoriásica/patologia
Artrite Reumatoide/diagnóstico por imagem
Artrite Reumatoide/metabolismo
Artrite Reumatoide/patologia
Complexo CD3/metabolismo
Colágeno/metabolismo
Quimioterapia Combinada
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Metotrexato/uso terapêutico
Meia-Idade
Molécula-1 de Adesão Celular Endotelial de Plaquetas/metabolismo
Receptores de Complemento 3d/metabolismo
Recidiva
Indução de Remissão
Membrana Sinovial/diagnóstico por imagem
Membrana Sinovial/metabolismo
Membrana Sinovial/patologia
Sinovite/diagnóstico por imagem
Sinovite/metabolismo
Sinovite/patologia
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Ultrassonografia
Ultrassonografia Doppler
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Antigens, CD20); 0 (Antigens, Differentiation, Myelomonocytic); 0 (Antirheumatic Agents); 0 (CD3 Complex); 0 (CD68 antigen, human); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (Receptors, Complement 3d); 0 (Tumor Necrosis Factor-alpha); 9007-34-5 (Collagen); FYS6T7F842 (Adalimumab); OP401G7OJC (Etanercept); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1136/annrheumdis-2016-210424


  10 / 1210 MEDLINE  
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[PMID]:28110206
[Au] Autor:Hosoi H; Imadome KI; Tamura S; Kuriyama K; Murata S; Yamashita Y; Mushino T; Oiwa T; Kobata H; Nishikawa A; Nakakuma H; Hanaoka N; Isobe Y; Ohshima K; Sonoki T
[Ad] Endereço:Hematology/Oncology, Wakayama Medical University, Japan.
[Ti] Título:An Epstein-Barr virus susceptible immature T-cell line, WILL4, established from a patient with T-lymphoblastic lymphoma bearing CD21 and a clonal EBV genome.
[So] Source:Leuk Res;55:1-5, 2017 Apr.
[Is] ISSN:1873-5835
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We managed a patient with an Epstein-Barr virus-associated T-cell lymphoblastic lymphoma. Mediastinal tumor cells at initial admission were positive for CD4, CD8, and TdT. Interestingly, a lymph node at necropsy was compatible for a CD4-positive peripheral T-cell lymphoma without CD8 and TdT expression, suggesting a different phenotype from the mediastinal tumor. Tumor cells in pleural effusion continued to proliferate in in vitro and were designated as WILL4. WILL4 cells were positive for CD3, CD4, CD8, CD21, T-cell receptor (TcR) αß, and TdT, indicating a similar phenotype to thymocytes. Southern blot analyses showed that the pleural tumor and WILL4 cells shared a TcR gene rearrangement, and that both contained a clonal EBV genome in an episomal form. RT-PCR showed that EBNA1 and LMP1 were expressed in the fresh tumor and WILL4 cells. Southern blot analyses revealed that WILL4 cells were susceptible to EBV infection in vitro using B95-8 supernatant. Anti-CD21 antibody inhibited in vitro infection of EBV, suggesting that CD21 plays a role in EBV infection into WILL4 cells. In vitro infection of EBV did not affect latent gene expression in WILL4 cells. WILL4 is a useful tool for analyzing the roles of EBV in onocogenesis in immature T-lymphoid malignancies.
[Mh] Termos MeSH primário: Herpesvirus Humano 4/genética
Linfoma de Células T Periférico/patologia
[Mh] Termos MeSH secundário: Linhagem Celular
Infecções por Vírus Epstein-Barr
Rearranjo Gênico do Linfócito T
Genoma Viral
Seres Humanos
Imunofenotipagem
Linfoma de Células T Periférico/virologia
Derrame Pleural Maligno/patologia
Reação em Cadeia da Polimerase em Tempo Real
Receptores de Complemento 3d/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Complement 3d)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE



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