Base de dados : MEDLINE
Pesquisa : D12.776.543.750.705.895.500.484 [Categoria DeCS]
Referências encontradas : 39 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 4 ir para página            

  1 / 39 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28938026
[Au] Autor:Jackson E; Zhang CX; Kiani Z; Lisovsky I; Tallon B; Del Corpo A; Gilbert L; Bruneau J; Thomas R; Côté P; Trottier B; LeBlanc R; Rouleau D; Tremblay C; Tsoukas CM; Routy JP; Ni X; Mabanga T; Bernard NF; Montreal Primary Infection Study Group
[Ad] Endereço:Research Institute of the McGill University Health Center (RI-MUHC), Montreal, Quebec, Canada.
[Ti] Título:HIV exposed seronegative (HESN) compared to HIV infected individuals have higher frequencies of telomeric Killer Immunoglobulin-like Receptor (KIR) B motifs; Contribution of KIR B motif encoded genes to NK cell responsiveness.
[So] Source:PLoS One;12(9):e0185160, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previously, we showed that Killer Immunoglobulin-like Receptor (KIR)3DS1 homozygotes (hmz) are more frequent in HIV exposed seronegative (HESN) than in recently HIV infected (HIV+) individuals. KIR3DS1 encodes an activating Natural Killer (NK) cell receptor (NKR). The link between KIR genotype and HIV outcomes likely arises from the function that NK cells acquire through expression of particular NKRs. An initial screen of 97 HESN and 123 HIV+ subjects for the frequency of KIR region gene carriage observed between-group differences for several telomeric KIR region loci. In a larger set of up to 106 HESN and 439 HIV+ individuals, more HESN than HIV+ subjects were KIR3DS1 homozygotes, lacked a full length KIR2DS4 gene and carried the telomeric group B KIR haplotype motif, TB01. TB01 is characterized by the presence of KIR3DS1, KIR2DL5A, KIR2DS3/5 and KIR2DS1, in linkage disequilibrium with each other. We assessed which of the TB01 encoded KIR gene products contributed to NK cell responsiveness by stimulating NK cells from 8 HIV seronegative KIR3DS1 and TB01 motif homozygotes with 721.221 HLA null cells and evaluating the frequency of KIR3DS1+/-KIR2DL5+/-, KIR3DS1+/-KIR2DS1+/-, KIR3DS1+/-KIR2DS5+/- NK cells secreting IFN-γ and/or expressing CD107a. A higher frequency of NK cells expressing, versus not, KIR3DS1 responded to 721.221 stimulation. KIR2DL5A+, KIR2DS1+ and KIR2DS5+ NK cells did not contribute to 721.221 responses or modulate those by KIR3DS1+ NK cells. Thus, of the TB01 KIR gene products, only KIR3DS1 conferred responsiveness to HLA-null stimulation, demonstrating its ligation can activate ex vivo NK cells.
[Mh] Termos MeSH primário: Infecções por HIV/imunologia
Soronegatividade para HIV
Células Matadoras Naturais/imunologia
Ativação Linfocitária
Receptores KIR3DS1/genética
Receptores KIR3DS1/metabolismo
[Mh] Termos MeSH secundário: Células Cultivadas
Técnicas de Cocultura
Frequência do Gene
Carga Genética
Infecções por HIV/genética
Antígenos HLA/imunologia
Haplótipos
Seres Humanos
Desequilíbrio de Ligação
Estudos Prospectivos
Receptores KIR/genética
Receptores KIR/metabolismo
Receptores KIR2DL5/genética
Receptores KIR2DL5/metabolismo
Receptores KIR3DS1/química
Telômero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HLA Antigens); 0 (KIR2DS1 protein, human); 0 (KIR2DS5 protein, human); 0 (Receptors, KIR); 0 (Receptors, KIR2DL5); 0 (Receptors, KIR3DS1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185160


  2 / 39 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27277336
[Au] Autor:Alvarado-Hernández DL; Benítez-Sánchez A; Rodríguez-Cuevas JS; Rosales-Saavedra T; Guerra-Palomares SE; Comas-García A; Noyola DE; García-Sepúlveda CA
[Ad] Endereço:Laboratorio de Genómica Viral y Humana, Facultad de Medicina UASLP, San Luis Potosí, México.
[Ti] Título:Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy.
[So] Source:Int J Immunogenet;43(4):189-99, 2016 Aug.
[Is] ISSN:1744-313X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human cytomegalovirus (CMV) represents an important public health concern as it is associated with severe morbidity and mortality in transplant recipients, HIV-infected individuals and pregnant women given the risk of congenital infection. Congenital CMV is a leading cause of neurological sequelae, developmental delay and birth defects worldwide. Cytomegalovirus can be transmitted to the foetus following maternal infection or reactivation. NK cells expressing killer-cell immunoglobulin-like receptors (KIR) are part of the innate immune system and the first line of defence against viral incursions. Previous reports have shown that KIR genes are associated with CMV infections in the post-transplant setting. In this study, we set out to determine whether a protective effect of KIR genes over CMV infection is seen in Mexican pregnant women. Cytomegalovirus infection was assessed through nucleic acid testing in 200 pregnant women and 600 healthy blood donors comprising the Mexican mestizo reference population. Killer-cell immunoglobulin-like receptors and HLA-C genotypes were obtained from 200 pregnant women and 300 reference samples using a comprehensive PCR-SSP approach. We observed statistically lower carrier frequencies of cB03|tA01 gene-content haplotype, of cB03 haplotype motif, of the KIR2DL5 + 2DS3/2DS5 gene pair and of KIR2DL5 amongst CMV-positive pregnant women in comparison with those CMV negative. None of these were associated with CMV status in the reference population. Logistic regression analysis revealed that the most important factor determining CMV status during third-trimester pregnancies was the KIR2DL5 + 2DS3/2DS5 gene pair (OR 0.376 (95%CI 0.174, 0.811, P = 0.013). Our results indicate that CMV-protective KIR gene associations described in Caucasoid populations are also present in the genetically distinct Mexican mestizo population. Our results suggest that certain KIR gene combinations provide protection against CMV infections occurring during late-term pregnancies, a finding of utmost epidemiological importance given its implication with congenital CMV infections.
[Mh] Termos MeSH primário: Infecções por Citomegalovirus/genética
Imunidade Inata/genética
Receptores KIR2DL5/genética
Receptores KIR/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Citomegalovirus/imunologia
Citomegalovirus/patogenicidade
Infecções por Citomegalovirus/imunologia
Infecções por Citomegalovirus/virologia
Feminino
Estudos de Associação Genética
Genótipo
Antígenos HLA-C/genética
Antígenos HLA-C/imunologia
Haplótipos
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Seres Humanos
Células Matadoras Naturais/imunologia
Gravidez
Receptores KIR/imunologia
Receptores KIR2DL5/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HLA-C Antigens); 0 (KIR2DS3 protein, human); 0 (Receptors, KIR); 0 (Receptors, KIR2DL5)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.1111/iji.12271


  3 / 39 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26960450
[Au] Autor:Tozkir JD; Tozkir H; Gürkan H; Dönmez S; Eker D; Pamuk GE; Pamuk ÖN
[Ad] Endereço:Health Services Vocational College, Trakya University, Edirne, Turkey. jduymaz@gmail.com.
[Ti] Título:The investigation of killer cell immunoglobulin-like receptor genotyping in patients with systemic lupus erytematosus and systemic sclerosis.
[So] Source:Clin Rheumatol;35(4):919-25, 2016 Apr.
[Is] ISSN:1434-9949
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the production of autoantibodies and the involvement of multiple organ systems. Systemic sclerosis (SSc) is another autoimmune disease that causes fibrosis. We will aim to analyse the role of killer cell immunoglobulin-like receptor (KIR) genotypes and their existence with the respective HLA ligands in patients with SLE and SSc. Forty-five SLE, 25 SSc and 40 healthy controls were included. We examined the presence/absence of KIR2DL1, 2DL2, 2DL3, 2DL4, 2DL5A, 2DL5B, 2DS1, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5, 3DL1, 3DL2, 3DL3, 3DS1, 2DP1, 3DP1 and their known HLA ligands. In the SLE group, the KIR2DL5, KIR2DL5B and KIR2DS3 genes were significantly more frequent, and KIR2DL3 gene was significantly less than in controls (p values <0.05). In SSc patients, the KIR2DS3 gene was more frequent than in controls (p = 0.032). The KIR2DL3 gene was detected more frequently in controls while KIR2DS3 gene was more frequent in the patient group when SLE and SSc patients were combined (p values < 0.05). The KIR2DS2/HLA-C and KIR2DS2/HLA-C combinations were significantly more in both SLE and SSc groups than in controls. The KIR2DL2 and KIR2DL5B genes were protective from neurologic involvement in SLE patients (p values <0.05). The variations of some KIR genes such as KIR2DL5, KIR2DL5B, KIR2DS3 and KIR2DL3 may have a role in the pathogenesis of SLE and SSc. Also, the presence of KIR2DL2 and KIR2DL5B may cause major organ involvement, like neurologic involvement, in SLE.
[Mh] Termos MeSH primário: Genótipo
Lúpus Eritematoso Sistêmico/genética
Receptores KIR/genética
Escleroderma Sistêmico/genética
[Mh] Termos MeSH secundário: Adulto
Alelos
Estudos de Casos e Controles
Feminino
Frequência do Gene
Antígenos HLA-C/genética
Haplótipos
Seres Humanos
Ligantes
Lúpus Eritematoso Sistêmico/imunologia
Masculino
Receptores KIR2DL2/genética
Receptores KIR2DL3/genética
Receptores KIR2DL5/genética
Escleroderma Sistêmico/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HLA-C Antigens); 0 (KIR2DL2 protein, human); 0 (KIR2DL3 protein, human); 0 (KIR2DL5B protein, human); 0 (KIR2DS3 protein, human); 0 (Ligands); 0 (Receptors, KIR); 0 (Receptors, KIR2DL2); 0 (Receptors, KIR2DL3); 0 (Receptors, KIR2DL5)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160311
[St] Status:MEDLINE
[do] DOI:10.1007/s10067-016-3222-0


  4 / 39 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26500342
[Au] Autor:Yeung DT; Tang C; Vidovic L; White DL; Branford S; Hughes TP; Yong AS
[Ad] Endereço:Department of Genetics and Molecular Pathology, Centre for Cancer Biology, and Department of Haematology, SA Pathology, Adelaide, SA, Australia; School of Medicine and.
[Ti] Título:KIR2DL5B genotype predicts outcomes in CML patients treated with response-directed sequential imatinib/nilotinib strategy.
[So] Source:Blood;126(25):2720-3, 2015 Dec 17.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Killer immunoglobulin-like receptors (KIRs) on natural killer (NK) cells have been shown to predict for response in chronic phase-chronic myeloid leukemia (CP-CML) patients treated with tyrosine kinase inhibitors. We performed KIR genotyping in 148 newly diagnosed CP-CML patients treated with a novel sequential imatinib/nilotinib strategy aimed at achievement of optimal molecular responses at defined time points. We found the presence of KIR2DL5B to be associated with inferior transformation-free survival and event-free survival and an independent predictor of inferior major molecular response (BCR-ABL1 ≤0.1%) and molecular response 4.5 (BCR-ABL1 ≤0.0032%). This suggests a critical early role for NK cells in facilitating response to imatinib that cannot be overcome by subsequent intensification of therapy. KIR genotyping may add valuable prognostic information to future baseline predictive scoring systems in CP-CML patients and facilitate optimal frontline treatment selection.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Resistência a Medicamentos Antineoplásicos/genética
Leucemia Mielogênica Crônica BCR-ABL Positiva/genética
Receptores KIR2DL5/genética
[Mh] Termos MeSH secundário: Genótipo
Seres Humanos
Mesilato de Imatinib/administração & dosagem
Estimativa de Kaplan-Meier
Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico
Leucemia Mielogênica Crônica BCR-ABL Positiva/mortalidade
Pirimidinas/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide); 0 (KIR2DL5B protein, human); 0 (Pyrimidines); 0 (Receptors, KIR2DL5); 8A1O1M485B (Imatinib Mesylate)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151218
[Lr] Data última revisão:
151218
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151027
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2015-07-655589


  5 / 39 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26032326
[Au] Autor:Hardcastle SL; Brenu EW; Johnston S; Nguyen T; Huth T; Wong N; Ramos S; Staines D; Marshall-Gradisnik S
[Ad] Endereço:National Centre for Neuroimmunology and Emerging Diseases, Griffith Health Centre, School of Medical Science, Griffith University, Gold Coast, QLD, Australia. sharni.hardcastle@hotmail.com.
[Ti] Título:Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
[So] Source:BMC Immunol;16:35, 2015 Jun 02.
[Is] ISSN:1471-2172
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Abnormal immune function is often an underlying component of illness pathophysiology and symptom presentation. Functional and phenotypic immune-related alterations may play a role in the obscure pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The objective of this study was to investigate the functional ability of innate and adaptive immune cells in moderate and severe CFS/ME patients. The 1994 Fukuda criteria for CFS/ME were used to define CFS/ME patients. CFS/ME participants were grouped based on illness severity with 15 moderately affected (moderate) and 12 severely affected (severe) CFS/ME patients who were age and sex matched with 18 healthy controls. Flow cytometric protocols were used for immunological analysis of dendritic cells, monocytes and neutrophil function as well as measures of lytic proteins and T, natural killer (NK) and B cell receptors. RESULTS: CFS/ME patients exhibited alterations in NK receptors and adhesion markers and receptors on CD4(+)T and CD8(+)T cells. Moderate CFS/ME patients had increased CD8(+) CD45RA effector memory T cells, SLAM expression on NK cells, KIR2DL5(+) on CD4(+)T cells and BTLA4(+) on CD4(+)T central memory cells. Moderate CFS/ME patients also had reduced CD8(+)T central memory LFA-1, total CD8(+)T KLRG1, naïve CD4(+)T KLRG1 and CD56(dim)CD16(-) NK cell CD2(+) and CD18(+)CD2(+). Severe CFS/ME patients had increased CD18(+)CD11c(-) in the CD56(dim)CD16(-) NK cell phenotype and reduced NKp46 in CD56(bright)CD16(dim) NK cells. CONCLUSIONS: This research accentuated the presence of immunological abnormalities in CFS/ME and highlighted the importance of assessing functional parameters of both innate and adaptive immune systems in the illness.
[Mh] Termos MeSH primário: Síndrome de Fadiga Crônica/imunologia
Síndrome de Fadiga Crônica/patologia
Receptores Imunológicos/metabolismo
[Mh] Termos MeSH secundário: Adulto
Linfócitos B Reguladores/imunologia
Contagem de Células Sanguíneas
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Adesão Celular
Separação Celular
Citotoxicidade Imunológica
Células Dendríticas/imunologia
Síndrome de Fadiga Crônica/sangue
Feminino
Citometria de Fluxo
Seres Humanos
Células Matadoras Naturais/imunologia
Masculino
Meia-Idade
Monócitos/imunologia
Neutrófilos/imunologia
Fenótipo
Receptores de Antígenos de Linfócitos B/metabolismo
Receptores KIR2DL5/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Antigen, B-Cell); 0 (Receptors, Immunologic); 0 (Receptors, KIR2DL5)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150603
[St] Status:MEDLINE
[do] DOI:10.1186/s12865-015-0101-4


  6 / 39 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25700262
[Au] Autor:De Re V; Caggiari L; De Zorzi M; Repetto O; Zignego AL; Izzo F; Tornesello ML; Buonaguro FM; Mangia A; Sansonno D; Racanelli V; De Vita S; Pioltelli P; Vaccher E; Berretta M; Beretta M; Mazzaro C; Libra M; Gini A; Zucchetto A; Cannizzaro R; De Paoli P
[Ad] Endereço:Facility Bio-proteomica/Dir. Sc, CRO National Cancer Institute, Aviano, Pordenone, Italy.
[Ti] Título:Genetic diversity of the KIR/HLA system and susceptibility to hepatitis C virus-related diseases.
[So] Source:PLoS One;10(2):e0117420, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The variability in the association of host innate immune response to Hepatitis C virus (HCV) infection requires ruling out the possible role of host KIR and HLA genotypes in HCV-related disorders: therefore, we therefore explored the relationships between KIR/HLA genotypes and chronic HCV infection (CHC) as they relate to the risk of HCV-related hepatocarcinoma (HCC) or lymphoproliferative disease progression. METHODS AND FINDINGS: We analyzed data from 396 HCV-positive patients with CHC (n = 125), HCC (118), and lymphoproliferative diseases (153), and 501 HCV-negative patients. All were HIV and HBV negative. KIR-SSO was used to determine the KIR typing. KIR2DL5 and KIR2DS4 variants were performed using PCR and GeneScan analysis. HLA/class-I genotyping was performed using PCR-sequence-based typing. The interaction between the KIR gene and ligand HLA molecules was investigated. Differences in frequencies were estimated using Fisher's exact test, and Cochran-Armitage trend test. The non-random association of KIR alleles was estimated using the linkage disequilibrium test. We found an association of KIR2DS2/KIR2DL2 genes, with the HCV-related lymphoproliferative disorders. Furthermore, individuals with a HLA-Bw6 KIR3DL1+ combination of genes showed higher risk of developing lymphoma than cryoglobulinemia. KIR2DS3 gene was found to be the principal gene associated with chronic HCV infection, while a reduction of HLA-Bw4 + KIR3DS1+ was associated with an increased risk of developing HCC. CONCLUSIONS: Our data highlight a role of the innate-system in developing HCV-related disorders and specifically KIR2DS3 and KIR2D genes demonstrated an ability to direct HCV disease progression, and mainly towards lymphoproliferative disorders. Moreover the determination of KIR3D/HLA combination of genes direct the HCV progression towards a lymphoma rather than an hepatic disease. In this contest IFN-α therapy, a standard therapy for HCV-infection and lymphoproliferative diseases, known to be able to transiently enhance the cytotoxicity of NK-cells support the role of NK cells to counterstain HCV-related and lymphoproliferative diseases.
[Mh] Termos MeSH primário: Predisposição Genética para Doença
Antígenos HLA/genética
Hepacivirus/fisiologia
Hepatite C/patologia
Receptores KIR/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Centrômero/genética
Feminino
Frequência do Gene
Loci Gênicos
Genótipo
Hepatite C/complicações
Hepatite C/genética
Seres Humanos
Desequilíbrio de Ligação
Masculino
Meia-Idade
Receptores KIR2DL5/genética
Telômero/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HLA Antigens); 0 (KIR2DS4 protein, human); 0 (Receptors, KIR); 0 (Receptors, KIR2DL5)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0117420


  7 / 39 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25253288
[Au] Autor:Jones DC; Peacock S; Hughes D; Traherne JA; Allen RL; Barnardo MC; Friend P; Taylor CJ; Fuggle S; Trowsdale J; Young NT
[Ad] Endereço:Department of Pathology, University of Cambridge, Cambridge, UK.
[Ti] Título:Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients.
[So] Source:Genes Immun;15(8):562-8, 2014 Dec.
[Is] ISSN:1476-5470
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Killer cell immunoglobulin-like receptors (KIR) are highly polymorphic members of the immunoglobulin superfamily, which influence the response of natural killer cells and some T-lymphocyte subsets. Analysis of a cohort of previously human cytomegalovirus (HCMV)-negative patients, who developed primary HCMV infection following HCMV-positive renal transplant (n=76), revealed an increase in the frequency of KIR genes located on the telomeric region of B haplotypes (Tel B). The presence of Tel B in combination with the KIR ligand HLA-C2 was significantly more frequent in this subgroup. These genetic factors were associated with resistance to HCMV infection in a second cohort (n=65), where the Tel B genes KIR2DL5, -2DS1, 2DS5 and -3DS1 were all significantly associated with high viral loads. Furthermore, the KIR haplotype Tel A when in combination with the KIR ligand HLA-C1 was significantly protective against the development of severe infection. Our results suggest that KIR are a significant factor in the control of primary HCMV infection, and that determination of KIR gene repertoire may help in detection of renal transplant patients who were most at risk.
[Mh] Termos MeSH primário: Infecções por Citomegalovirus/genética
Transplante de Rim/métodos
Receptores KIR/genética
Carga Viral
[Mh] Termos MeSH secundário: Estudos de Coortes
Citomegalovirus/fisiologia
Infecções por Citomegalovirus/etiologia
Infecções por Citomegalovirus/virologia
Predisposição Genética para Doença/genética
Genótipo
Antígenos HLA-C/genética
Haplótipos
Interações Hospedeiro-Patógeno
Seres Humanos
Transplante de Rim/efeitos adversos
Receptores KIR2DL5/genética
Receptores KIR3DS1/genética
Fatores de Risco
Índice de Gravidade de Doença
Telômero/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HLA-C Antigens); 0 (KIR2DS1 protein, human); 0 (KIR2DS5 protein, human); 0 (Receptors, KIR); 0 (Receptors, KIR2DL5); 0 (Receptors, KIR3DS1)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140926
[St] Status:MEDLINE
[do] DOI:10.1038/gene.2014.53


  8 / 39 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24929143
[Au] Autor:Olaniyan SA; Amodu OK; Yindom LM; Conway DJ; Aka P; Bakare AA; Omotade OO
[Ad] Endereço:Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address: subulade.olaniyan@yahoo.com.
[Ti] Título:Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.
[So] Source:Hum Immunol;75(8):816-21, 2014 Aug.
[Is] ISSN:1879-1166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Killer-cell immunoglobulin-like receptors (KIRs) are a group of natural killer cell receptors (NKRs) that regulate NK-cell-mediated production of interferon gamma (IFN-γ) in response to infection. These receptors have recently been suggested to influence the severity of clinical Plasmodium falciparum malaria infection. We examined the KIR locus in relation to malaria in children from southwest Nigeria. Sequence specific priming (SSP)-PCR was used to detect the KIR genes. The presence or absence of fifteen different KIR genes was determined in each individual and the proportions compared across 3 clinical groups; asymptomatic malaria, uncomplicated clinical malaria and severe clinical malaria. The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases. Furthermore, KIR2DS3 and KIR2DS5 were present in a higher proportion of uncomplicated malaria cases than severe malaria cases. Carriage c-AB2 genotype (which comprises all centromeric KIR genes including KIR2DL5, KIR2DS3 and KIR2DS5) decreases with severity of the disease suggesting that the KIR AB profile might be associated with protection from severe malaria infection in this population in Nigeria.
[Mh] Termos MeSH primário: Células Matadoras Naturais/imunologia
Malária Falciparum/genética
Plasmodium falciparum/imunologia
Receptores KIR2DL5/genética
Receptores KIR/genética
[Mh] Termos MeSH secundário: Alelos
Doenças Assintomáticas
Pré-Escolar
Feminino
Expressão Gênica
Frequência do Gene
Genótipo
Seres Humanos
Lactente
Interferon gama/genética
Interferon gama/imunologia
Células Matadoras Naturais/parasitologia
Malária Falciparum/imunologia
Malária Falciparum/parasitologia
Malária Falciparum/patologia
Masculino
Nigéria
Receptores KIR/imunologia
Receptores KIR2DL5/imunologia
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (KIR2DS3 protein, human); 0 (KIR2DS5 protein, human); 0 (Receptors, KIR); 0 (Receptors, KIR2DL5); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140804
[Lr] Data última revisão:
140804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140615
[St] Status:MEDLINE


  9 / 39 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:23234877
[Au] Autor:Chong MS; Goh LK; Lim WS; Chan M; Tay L; Chen G; Feng L; Ng TP; Tan CH; Lee TS
[Ad] Endereço:Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore. Mei_Sian_Chong@ttsh.com.sg
[Ti] Título:Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.
[So] Source:J Alzheimers Dis;34(2):399-405, 2013.
[Is] ISSN:1875-8908
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We previously reported TOMM40 was significantly down-regulated in whole blood of Alzheimer's disease (AD) subjects. In this study, we examined whole blood gene profiling differences over a one-year period comparing early AD subjects based on disease progression. 6-monthly assessments and blood sampling on 29 probable AD subjects compared with age- and gender-matched controls were performed. AD subjects with change in Clinical Dementia Rating-Sum of Boxes (CDR-SB) score of ≥2 points/year were classified as fast-progressors and those with CDR-SB change of <2 points/year were classified as slow-progressors. We found statistically significant upregulation in KIR2DL5A, SLC2A8, and PLOD1 for fast- (n = 8) compared with slow-progressors (n = 21) across the time-points. TOMM40 gene expression remained significantly lower in AD patients at all time-points compared to controls, supporting our previous findings. Our novel findings of specific gene expression differences between fast- and slow-progressors in combination with consistently lower TOMM40 expression, suggest their potential role as prognostic blood biomarkers to predict progression in early AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/sangue
Regulação para Baixo/fisiologia
Proteínas Facilitadoras de Transporte de Glucose/biossíntese
Leucócitos Mononucleares/metabolismo
Proteínas de Membrana Transportadoras/metabolismo
Pró-Colágeno-Lisina 2-Oxoglutarato 5-Dioxigenase/biossíntese
Receptores KIR2DL5/biossíntese
Regulação para Cima/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/diagnóstico
Doença de Alzheimer/genética
Biomarcadores/sangue
Progressão da Doença
Diagnóstico Precoce
Feminino
Perfilação da Expressão Gênica/métodos
Proteínas Facilitadoras de Transporte de Glucose/genética
Seres Humanos
Estudos Longitudinais
Masculino
Proteínas de Membrana Transportadoras/genética
Pró-Colágeno-Lisina 2-Oxoglutarato 5-Dioxigenase/genética
Estudos Prospectivos
Receptores KIR2DL5/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Glucose Transport Proteins, Facilitative); 0 (KIR2DL5A protein, human); 0 (Membrane Transport Proteins); 0 (Receptors, KIR2DL5); 0 (SLC2A8 protein, human); 0 (TOMM40 protein, human); EC 1.14.11.4 (PLOD1 protein, human); EC 1.14.11.4 (Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121214
[St] Status:MEDLINE
[do] DOI:10.3233/JAD-121621


  10 / 39 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22652695
[Au] Autor:Aranda-Romo S; Garcia-Sepulveda CA; Comas-García A; Lovato-Salas F; Salgado-Bustamante M; Gómez-Gómez A; Noyola DE
[Ad] Endereço:Departamento de Microbiología, Universidad Autónoma de San Luis Potosí, Avenida Venustiano Carranza #2405, Colonia los Filtros, 78210 San Luis Potosí, Mexico.
[Ti] Título:Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.
[So] Source:Immunogenetics;64(9):653-62, 2012 Sep.
[Is] ISSN:1432-1211
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Introduction of a novel influenza virus into the human population leads to the occurrence of pandemic events, such as the one caused by pandemic influenza A (H1N1) 2009 virus. The severity of infections caused by this virus in young adults was greater than that observed in patients with seasonal influenza. Fatal cases have been associated with an abnormal innate, proinflammatory immune response. A critical role for natural killer cells during the initial responses to influenza infections has been suggested. In this study, we assessed the association of killer-cell immunoglobulin-like receptors (KIRs) with disease severity by comparing KIR gene content in patients with mild and severe pandemic influenza virus infections to a control group. We found that activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5) genes, encoded in group B haplotypes containing the cB01, cB03 and tB01 motifs, are associated with severe pandemic influenza A (H1N1) 2009 infections. Better understanding of how genetic variability contributes to influenza virus pathogenesis may help to the development of immune intervention strategies aiming at controlling the severity of disease.
[Mh] Termos MeSH primário: Vírus da Influenza A Subtipo H1N1
Influenza Humana/genética
Receptores KIR2DL5/genética
Receptores KIR3DS1/genética
Receptores KIR/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Motivos de Aminoácidos
Criança
Pré-Escolar
Feminino
Frequência do Gene
Genótipo
Haplótipos
Seres Humanos
Influenza Humana/epidemiologia
Influenza Humana/patologia
Masculino
México/epidemiologia
Meia-Idade
Pandemias
Isoformas de Proteínas/genética
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (KIR2DS5 protein, human); 0 (Protein Isoforms); 0 (Receptors, KIR); 0 (Receptors, KIR2DL5); 0 (Receptors, KIR3DS1)
[Em] Mês de entrada:1210
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120602
[St] Status:MEDLINE
[do] DOI:10.1007/s00251-012-0623-3



página 1 de 4 ir para página            
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde