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[PMID]:28821389
[Au] Autor:Wingen A; Carrera P; Ekaterini Psathaki O; Voelzmann A; Paululat A; Hoch M
[Ad] Endereço:Developmental Genetic&Molecular Physiology Unit, Life&Medical Sciences Institute (LIMES), University of Bonn, Carl-Troll-Strasse 31, D-53115 Bonn, Germany.
[Ti] Título:Debris buster is a Drosophila scavenger receptor essential for airway physiology.
[So] Source:Dev Biol;430(1):52-68, 2017 10 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scavenger receptors class B (SR-B) are multifunctional transmembrane proteins, which in vertebrates participate in lipid transport, pathogen clearance, lysosomal delivery and intracellular sorting. Drosophila has 14 SR-B members whose functions are still largely unknown. Here, we reveal a novel role for the SR-B family member Debris buster (Dsb) in Drosophila airway physiology. Larvae lacking dsb show yeast avoidance behavior, hypoxia, and severe growth defects associated with impaired elongation and integrity along the airways. Furthermore, in dsb mutant embryos, the barrier function of the posterior spiracles, which are critical for gas exchange, is not properly established and liquid clearance is locally impaired at the spiracular lumen. We found that Dsb is specifically expressed in a group of distal epithelial cells of the posterior spiracle organ and not throughout the entire airways. Furthermore, tissue-specific knockdown and rescue experiments demonstrate that Dsb function in the airways is only required in the posterior spiracles. Dsb localizes in intracellular vesicles, and a subset of these associate with lysosomes. However, we found that depletion of proteins involved in vesicular transport to the apical membrane, but not in lysosomal function, causes dsb-like airway elongation defects. We propose a model in which Dsb sorts components of the apical extracellular matrix which are essential for airway physiology. Since SR-B LIMP2-deficient mice show reduced expression of several apical plasma membrane proteins, sorting of proteins to the apical membrane is likely an evolutionary conserved function of Dsb and LIMP2. Our data provide insights into a spatially confined function of the SR-B Dsb in intracellular trafficking critical for the physiology of the whole tubular airway network.
[Mh] Termos MeSH primário: Proteínas de Drosophila/metabolismo
Drosophila melanogaster/metabolismo
Receptores Depuradores/metabolismo
Fenômenos Fisiológicos Respiratórios
Sistema Respiratório/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Drosophila/genética
Drosophila melanogaster/citologia
Drosophila melanogaster/embriologia
Embrião não Mamífero/metabolismo
Matriz Extracelular/metabolismo
Regulação da Expressão Gênica
Hipóxia/metabolismo
Espaço Intracelular/metabolismo
Larva/metabolismo
Mutação/genética
Transporte Proteico
Interferência de RNA
Receptores Depuradores/genética
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Dsb protein, Drosophila); 0 (Receptors, Scavenger); 059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE


  2 / 2113 MEDLINE  
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[PMID]:28759013
[Au] Autor:Krawczyk KM; Nilsson H; Allaoui R; Lindgren D; Arvidsson M; Leandersson K; Johansson ME
[Ad] Endereço:Department of Translational Medicine, Center for Molecular Pathology, Lund University, Malmö, Sweden.
[Ti] Título:Papillary renal cell carcinoma-derived chemerin, IL-8, and CXCL16 promote monocyte recruitment and differentiation into foam-cell macrophages.
[So] Source:Lab Invest;97(11):1296-1305, 2017 Nov.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Papillary renal cell carcinoma (pRCC) is the second most common type of renal cell carcinoma. The only curative treatment available for pRCC is radical surgery. If the disease becomes widespread, neither chemo- nor radiotherapy will have therapeutic effect, hence further research on pRCC is of utmost importance. Histologically, pRCC is characterized by a papillary growth pattern with focal aggregation of macrophages of the foam cell phenotype. In other forms of cancer, a clear role for tumor-associated macrophages during cancer growth and progression has been shown. Although the presence of foamy macrophages is a histological hallmark of pRCC tumors, little is known regarding their role in pRCC biology. In order to study the interaction between pRCC tumor and myeloid cells, we established primary cultures from pRCC tissue. We show that human pRCC cells secrete the chemokines IL-8, CXCL16, and chemerin, and that these factors attract primary human monocytes in vitro. RNAseq data from The Cancer Genome Atlas confirmed a high expression of these factors in pRCC tissue. Conditioned medium from pRCC cultures induced a shift in human monocytes toward the M2 macrophage phenotype. In extended cultures, these macrophages became enlarged and loaded with lipids, adopting the foam cell morphology found in pRCC tissue. These results show for the first time that pRCC primary tumor cells secrete factors that attract and differentiate monocytes into anti-inflammatory tumor-associated macrophages with foam cell histology.
[Mh] Termos MeSH primário: Carcinoma de Células Renais/metabolismo
Quimiocinas CXC/metabolismo
Quimiocinas/metabolismo
Células Espumosas/metabolismo
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
Interleucina-8/metabolismo
Neoplasias Renais/metabolismo
Monócitos/metabolismo
Receptores Depuradores/metabolismo
[Mh] Termos MeSH secundário: Idoso
Carcinoma de Células Renais/imunologia
Carcinoma de Células Renais/patologia
Carcinoma de Células Renais/cirurgia
Transdiferenciação Celular
Células Cultivadas
Quimiocina CXCL16
Quimiocinas/secreção
Quimiocinas CXC/secreção
Quimiotaxia de Leucócito
Técnicas de Cocultura
Meios de Cultivo Condicionados
Células Espumosas/imunologia
Células Espumosas/patologia
Seres Humanos
Peptídeos e Proteínas de Sinalização Intercelular/secreção
Interleucina-8/secreção
Neoplasias Renais/imunologia
Neoplasias Renais/patologia
Neoplasias Renais/secreção
Masculino
Meia-Idade
Monócitos/imunologia
Monócitos/patologia
Gradação de Tumores
Proteínas de Neoplasias/metabolismo
Proteínas de Neoplasias/secreção
Nefrectomia
Carga Tumoral
Células Tumorais Cultivadas
Microambiente Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CXCL16 protein, human); 0 (Chemokine CXCL16); 0 (Chemokines); 0 (Chemokines, CXC); 0 (Culture Media, Conditioned); 0 (IL8 protein, human); 0 (Intercellular Signaling Peptides and Proteins); 0 (Interleukin-8); 0 (Neoplasm Proteins); 0 (Receptors, Scavenger); 0 (chemerin protein, human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2017.78


  3 / 2113 MEDLINE  
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[PMID]:28717031
[Au] Autor:Killpack TL; Ballesteros M; Bunnell SC; Bedugnis A; Kobzik L; Hu LT; Petnicki-Ocwieja T
[Ad] Endereço:Department of Biological Sciences, Wellesley College, Wellesley, Massachusetts, USA.
[Ti] Título:Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis.
[So] Source:Infect Immun;85(10), 2017 Oct.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phagocytosis of the Lyme disease-causing pathogen has been shown to be important for generating an inflammatory response to the pathogen. As a result, understanding the mechanisms of phagocytosis has been an area of great interest in the field of Lyme disease. Several cell surface receptors that participate in phagocytosis have been reported, including the scavenger receptor MARCO and integrin α3ß1. We sought to define the mechanisms by which these receptors mediate phagocytosis and to identify signaling pathways activated downstream of these receptors upon contact with We identified both Syk and Src signaling pathways as ones that participate in phagocytosis and the resulting cytokine activation. In our studies, we found that both MARCO and integrin ß1 play a role in the activation of the Src kinase pathway. However, only integrin ß1 participates in the activation of Syk. Interestingly, the integrin activates Syk without the help of the signaling adaptor Dap12 or FcRγ. Thus, we report that multiple pathways participate in internalization and that different cell surface receptors act simultaneously in cooperation and independently to mediate phagocytosis.
[Mh] Termos MeSH primário: Borrelia burgdorferi/imunologia
Cadeias beta de Integrinas/metabolismo
Fagocitose
Receptores Imunológicos/metabolismo
Transdução de Sinais
Quinase Syk/metabolismo
Quinases da Família src/metabolismo
[Mh] Termos MeSH secundário: Animais
Borrelia burgdorferi/fisiologia
Doença de Lyme/imunologia
Doença de Lyme/microbiologia
Camundongos
Receptores Imunológicos/imunologia
Receptores Depuradores/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Integrin beta Chains); 0 (Marco protein, mouse); 0 (Receptors, Immunologic); 0 (Receptors, Scavenger); EC 2.7.10.2 (Syk Kinase); EC 2.7.10.2 (Syk protein, mouse); EC 2.7.10.2 (src-Family Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


  4 / 2113 MEDLINE  
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[PMID]:28689990
[Au] Autor:Dowaidar M; Abdelhamid HN; Hällbrink M; Zou X; Langel Ü
[Ad] Endereço:Department of Neurochemistry, Stockholm University, Svante Arrhenius väg 16B, Stockholm SE-10691, Sweden. Electronic address: moataz@neurochem.su.se.
[Ti] Título:Graphene oxide nanosheets in complex with cell penetrating peptides for oligonucleotides delivery.
[So] Source:Biochim Biophys Acta;1861(9):2334-2341, 2017 09.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A new strategy for gene transfection using the nanocarrier of cell penetrating peptides (CPPs; PepFect14 (PF14) or PepFect14 (PF14) (PF221)) in complex with graphene oxide (GO) is reported. GO complexed with CPPs and plasmid (pGL3), splice correction oligonucleotides (SCO) or small interfering RNA (siRNA) are performed. Data show adsorption of CPPs and oligonucleotides on the top of the graphenic lamellar without any observed change of the particle size of GO. GO mitigates the cytotoxicity of CPPs and improves the material biocompatibility. Complexes of GO-pGL3-CPPs (CPPs; PF14 or PF221) offer 2.1-2.5 fold increase of the cell transfection compared to pGL3-CPPs (CPPs; PF14 or PF221). GO-SCO-PF14 assemblies effectively transfect the cells with an increase of >10-25 fold compared to the transfection using PF14. The concentration of GO plays a significant role in the material nanotoxicity and the transfection efficiency. The results open a new horizon in the gene treatment using CPPs and offer a simple strategy for further investigations.
[Mh] Termos MeSH primário: Peptídeos Penetradores de Células/química
Grafite/química
Oligonucleotídeos/administração & dosagem
Transfecção/métodos
[Mh] Termos MeSH secundário: Sobrevivência Celular
Células HeLa
Seres Humanos
Nanopartículas
Tamanho da Partícula
Receptores Depuradores/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cell-Penetrating Peptides); 0 (Oligonucleotides); 0 (Receptors, Scavenger); 7782-42-5 (Graphite)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE


  5 / 2113 MEDLINE  
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[PMID]:28639912
[Au] Autor:Zhang B; Cao M; He Y; Liu Y; Zhang G; Yang C; Du Y; Xu J; Hu J; Gao F
[Ad] Endereço:1 Department of Molecular Biology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
[Ti] Título:Increased circulating M2-like monocytes in patients with breast cancer.
[So] Source:Tumour Biol;39(6):1010428317711571, 2017 Jun.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:M2-like tumor-associated macrophages promote breast tumor growth and survival and may migrate into the peripheral blood. However, the frequency of circulating M2-like monocytes in the peripheral blood of breast cancer patients has not been clarified. The objective of this study was to determine the percentages of circulating M2-like monocytes in patients with breast cancer. Immunofluorescence staining for CD68 and CD163 was performed to detect M2-like macrophages in pathological tissues. Flow cytometry was used to assess the frequencies of circulating CD14 CD163 /CD14 CD204 /CD14 CD163 CD204 M2-like monocytes in 99 breast cancer patients, 56 patients with benign breast disease, and 60 healthy controls. Receiver operating characteristic curve analysis was used to compare the diagnostic values of circulating M2-like monocytes, carcinoembryonic antigen, and cancer antigen 15-3. The associations among circulating M2-like monocytes and clinical breast cancer parameters were analyzed. The number of CD68 CD163 M2-like macrophages was significantly higher in breast cancer tissues than in benign tissues. In the peripheral blood, CD14 CD163 /CD14 CD204 /CD14 CD163 CD204 M2-like monocytes were elevated in breast cancer patients compared with normal controls and patients with benign breast disease. The area under the receiver operating curve for circulating CD14 CD163 CD204 M2-like monocytes was 0.888 (95% confidence interval: 0.839-0.936), a value higher than those for carcinoembryonic antigen and cancer antigen 15-3. High frequencies of circulating CD14 CD204 and CD14 CD163 CD204 M2-like monocytes were associated with tumor-node-metastasis stage, lymph node metastasis, histological differentiation, and estrogen receptor expression. Circulating M2-like monocytes may serve as a diagnostic biomarker in breast cancer and have a potential role in reflecting breast cancer progression.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/sangue
Neoplasias da Mama/sangue
Receptores de Lipopolissacarídeos/sangue
Macrófagos/metabolismo
Glicoproteínas de Membrana/sangue
Receptores Depuradores/sangue
Receptores Depuradores Classe A/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasias da Mama/patologia
Progressão da Doença
Feminino
Citometria de Fluxo
Seres Humanos
Metástase Linfática
Macrófagos/patologia
Meia-Idade
Monócitos/metabolismo
Monócitos/patologia
Receptores de Superfície Celular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Lipopolysaccharide Receptors); 0 (M160 protein, human); 0 (MSR1 protein, human); 0 (Membrane Glycoproteins); 0 (Receptors, Cell Surface); 0 (Receptors, Scavenger); 0 (Scavenger Receptors, Class A)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317711571


  6 / 2113 MEDLINE  
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[PMID]:28600292
[Au] Autor:Reyat JS; Chimen M; Noy PJ; Szyroka J; Rainger GE; Tomlinson MG
[Ad] Endereço:School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom; and.
[Ti] Título:ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.
[So] Source:J Immunol;199(2):666-676, 2017 Jul 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The recruitment of blood leukocytes across the endothelium to sites of tissue infection is central to inflammation, but also promotes chronic inflammatory diseases. A disintegrin and metalloproteinase 10 (ADAM10) is a ubiquitous transmembrane molecular scissor that is implicated in leukocyte transmigration by proteolytically cleaving its endothelial substrates. These include VE-cadherin, a homotypic adhesion molecule that regulates endothelial barrier function, and transmembrane chemokines CX3CL1 and CXCL16, which have receptors on leukocytes. However, a definitive role for endothelial ADAM10 in transmigration of freshly isolated primary leukocytes under flow has not been demonstrated, and the relative importance of distinct ADAM10 substrates is unknown. Emerging evidence suggests that ADAM10 can be regarded as six different molecular scissors with different substrate specificities, depending on which of six TspanC8 tetraspanins it is associated with, but TspanC8s remain unstudied in leukocyte transmigration. In the current study, ADAM10 knockdown on primary HUVECs was found to impair transmigration of freshly isolated human peripheral blood T lymphocytes, but not neutrophils or B lymphocytes, in an in vitro flow assay. This impairment was due to delayed transmigration rather than a complete block, and was overcome in the presence of neutrophils. Transmigration of purified lymphocytes was dependent on ADAM10 regulation of VE-cadherin, but not CX3CL1 and CXCL16. Tspan5 and Tspan17, the two most closely related TspanC8s by sequence, were the only TspanC8s that regulated VE-cadherin expression and were required for lymphocyte transmigration. Therefore endothelial Tspan5- and Tspan17-ADAM10 complexes may regulate inflammation by maintaining normal VE-cadherin expression and promoting T lymphocyte transmigration.
[Mh] Termos MeSH primário: Proteína ADAM10/metabolismo
Secretases da Proteína Precursora do Amiloide/metabolismo
Antígenos CD/genética
Caderinas/genética
Proteínas de Membrana/metabolismo
Linfócitos T/fisiologia
Tetraspaninas/metabolismo
Migração Transendotelial e Transepitelial
[Mh] Termos MeSH secundário: Proteína ADAM10/deficiência
Proteína ADAM10/genética
Proteína ADAM10/imunologia
Secretases da Proteína Precursora do Amiloide/deficiência
Secretases da Proteína Precursora do Amiloide/genética
Secretases da Proteína Precursora do Amiloide/imunologia
Antígenos CD/metabolismo
Linfócitos B/imunologia
Linfócitos B/fisiologia
Caderinas/metabolismo
Células Cultivadas
Quimiocina CX3CL1/genética
Quimiocina CX3CL1/imunologia
Quimiocina CXCL16
Quimiocinas CXC/genética
Quimiocinas CXC/imunologia
Células Endoteliais/imunologia
Células Endoteliais/fisiologia
Seres Humanos
Inflamação/imunologia
Proteínas de Membrana/deficiência
Proteínas de Membrana/genética
Proteínas de Membrana/imunologia
Neutrófilos/imunologia
Neutrófilos/fisiologia
Receptores Depuradores/genética
Receptores Depuradores/imunologia
Linfócitos T/imunologia
Tetraspaninas/genética
Tetraspaninas/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (CX3CL1 protein, human); 0 (CXCL16 protein, human); 0 (Cadherins); 0 (Chemokine CX3CL1); 0 (Chemokine CXCL16); 0 (Chemokines, CXC); 0 (Membrane Proteins); 0 (Receptors, Scavenger); 0 (TSPAN17 protein, human); 0 (TSPAN5 protein, human); 0 (Tetraspanins); 0 (cadherin 5); EC 3.4.- (Amyloid Precursor Protein Secretases); EC 3.4.24.81 (ADAM10 Protein); EC 3.4.24.81 (ADAM10 protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1600713


  7 / 2113 MEDLINE  
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[PMID]:28552585
[Au] Autor:Morioka S; Nigorikawa K; Hazeki K; Ohmura M; Sakamoto H; Matsumura T; Takasuga S; Hazeki O
[Ad] Endereço:Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
[Ti] Título:Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages.
[So] Source:Exp Cell Res;357(2):252-259, 2017 Aug 15.
[Is] ISSN:1090-2422
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The findings of this study suggest that the phosphoinositide phosphatase Sac3 maintains the protein level of scavenger receptor A (SR-A) and regulates foam cell formation. RAW264.7 macrophages were transfected with short hairpin RNAs that target Sac3. The knockdown decreased the level of the cell surface SR-A and suppressed the acetylated low density lipoprotein-induced foam cell formation. The associated regulator of PIKfyve (ArPIKfyve) is a scaffold protein that protects Sac3 from proteasome-dependent degradation. The knockdown of ArPIKfyve decreased Sac3, cell surface SR-A, and foam cell formation. The knockdown of PIKfyve had no effect on SR-A protein levels. These results suggest that the ArPIKfyve-Sac3 complex regulates SR-A protein levels independently of its effect on PIKfyve activity.
[Mh] Termos MeSH primário: Flavoproteínas/metabolismo
Gotículas Lipídicas/metabolismo
Macrófagos/metabolismo
Fosfatases de Fosfoinositídeos/metabolismo
Monoéster Fosfórico Hidrolases/metabolismo
Receptores Depuradores/metabolismo
[Mh] Termos MeSH secundário: Animais
Membrana Celular/metabolismo
Flavoproteínas/genética
Técnicas de Silenciamento de Genes/métodos
Seres Humanos
Camundongos
Fosfatases de Fosfoinositídeos/genética
Monoéster Fosfórico Hidrolases/genética
Células RAW 264.7
Receptores Depuradores Classe A/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavoproteins); 0 (Receptors, Scavenger); 0 (Scavenger Receptors, Class A); EC 3.1.3.- (FIG4 protein, human); EC 3.1.3.2 (Phosphoric Monoester Hydrolases); EC 3.1.3.36 (Fig4 protein, mouse); EC 3.1.3.36 (Phosphoinositide Phosphatases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


  8 / 2113 MEDLINE  
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[PMID]:28504304
[Au] Autor:Vasquez M; Simões I; Consuegra-Fernández M; Aranda F; Lozano F; Berraondo P
[Ad] Endereço:Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
[Ti] Título:Exploiting scavenger receptors in cancer immunotherapy: Lessons from CD5 and SR-B1.
[So] Source:Eur J Immunol;47(7):1108-1118, 2017 Jul.
[Is] ISSN:1521-4141
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Scavenger receptors (SRs) are structurally heterogeneous cell surface receptors characterized by their capacity to remove extraneous or modified self-macromolecules from circulation, thus avoiding the accumulation of noxious agents in the extracellular space. This scavenging activity makes SRs important molecules for host defense and homeostasis. In turn, SRs keep the activation of the steady-state immune response in check, and participate as co-receptors in the priming of the effector immune responses when the macromolecules are associated with a threat that might compromise host homeostasis. Therefore, SRs built up sophisticated sensor mechanisms controlling the immune system, which may be exploited to develop novel drugs for cancer immunotherapy. In this review, we focus on the regulation of the anti-tumor immune response by two paradigmatic SRs: the lymphocyte receptor CD5 and the more broadly distributed scavenger receptor class B type 1 (SR-B1). Cancer immunity can be boosted by blockade of SRs working as immune checkpoint inhibitors (CD5) and/or by proper engagement of SRs working as innate danger receptor (SR-B1). Thus, these receptors illustrate both the complexity of targeting SRs in cancer immunotherapy and also the opportunities offered by such an approach.
[Mh] Termos MeSH primário: Antígenos CD5/metabolismo
Neoplasias/terapia
Receptores Depuradores/antagonistas & inibidores
Receptores Depuradores/metabolismo
Receptores Depuradores Classe B/antagonistas & inibidores
Receptores Depuradores Classe B/metabolismo
[Mh] Termos MeSH secundário: Animais
Antígenos CD5/imunologia
Homeostase
Seres Humanos
Imunoterapia/métodos
Camundongos
Neoplasias/imunologia
Neoplasias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (CD5 Antigens); 0 (Receptors, Scavenger); 0 (SCARB1 protein, human); 0 (Scavenger Receptors, Class B)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1002/eji.201646903


  9 / 2113 MEDLINE  
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[PMID]:28483986
[Au] Autor:PrabhuDas MR; Baldwin CL; Bollyky PL; Bowdish DME; Drickamer K; Febbraio M; Herz J; Kobzik L; Krieger M; Loike J; McVicker B; Means TK; Moestrup SK; Post SR; Sawamura T; Silverstein S; Speth RC; Telfer JC; Thiele GM; Wang XY; Wright SD; El Khoury J
[Ad] Endereço:Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852; mprabhudas@niaid.nih.gov jelkhoury@mgh.harvard.edu.
[Ti] Título:A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.
[So] Source:J Immunol;198(10):3775-3789, 2017 May 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands including endogenous and modified host-derived molecules and microbial pathogens. There are currently eight classes of scavenger receptors, many of which have multiple names, leading to inconsistencies and confusion in the literature. To address this problem, a workshop was organized by the United States National Institute of Allergy and Infectious Diseases, National Institutes of Health, to help develop a clear definition of scavenger receptors and a standardized nomenclature based on that definition. Fifteen experts in the scavenger receptor field attended the workshop and, after extensive discussion, reached a consensus regarding the definition of scavenger receptors and a proposed scavenger receptor nomenclature. Scavenger receptors were defined as cell surface receptors that typically bind multiple ligands and promote the removal of nonself or altered-self targets. They often function by mechanisms that include endocytosis, phagocytosis, adhesion, and signaling that ultimately lead to the elimination of degraded or harmful substances. Based on this definition, nomenclature and classification of these receptors into 10 classes were proposed. This classification was discussed at three national meetings and input from participants at these meetings was requested. The following manuscript is a consensus statement that combines the recommendations of the initial workshop and incorporates the input received from the participants at the three national meetings.
[Mh] Termos MeSH primário: Receptores Depuradores/classificação
Receptores Depuradores/fisiologia
[Mh] Termos MeSH secundário: Animais
Endocitose
Seres Humanos
Ligantes
Camundongos
National Institute of Allergy and Infectious Diseases (U.S.)/normas
Fagocitose
Receptores Imunológicos/fisiologia
Receptores Depuradores Classe A/fisiologia
Transdução de Sinais
Terminologia como Assunto
Estados Unidos
[Pt] Tipo de publicação:CONSENSUS DEVELOPMENT CONFERENCE, NIH; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); 0 (Receptors, Immunologic); 0 (Receptors, Scavenger); 0 (Scavenger Receptors, Class A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700373


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[PMID]:28447294
[Au] Autor:Zhang X; Yang P; Wang N; Zhang J; Li J; Guo H; Yin X; Rao Z; Wang X; Zhang L
[Ad] Endereço:Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
[Ti] Título:The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection.
[So] Source:Protein Cell;8(8):590-600, 2017 Aug.
[Is] ISSN:1674-8018
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Entero virus 71 (EV71) causes hand, foot, and mouth disease (HFMD) and occasionally leads to severe neurological complications and even death. Scavenger receptor class B member 2 (SCARB2) is a functional receptor for EV71, that mediates viral attachment, internalization, and uncoating. However, the exact binding site of EV71 on SCARB2 is unknown. In this study, we generated a monoclonal antibody (mAb) that binds to human but not mouse SCARB2. It is named JL2, and it can effectively inhibit EV71 infection of target cells. Using a set of chimeras of human and mouse SCARB2, we identified that the region containing residues 77-113 of human SCARB2 contributes significantly to JL2 binding. The structure of the SCARB2-JL2 complex revealed that JL2 binds to the apical region of SCARB2 involving α-helices 2, 5, and 14. Our results provide new insights into the potential binding sites for EV71 on SCARB2 and the molecular mechanism of EV71 entry.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/química
Enterovirus Humano A/efeitos dos fármacos
Fragmentos Fab das Imunoglobulinas/química
Glicoproteínas de Membrana Associadas ao Lisossomo/química
Receptores Depuradores/química
Receptores Virais/química
Proteínas Recombinantes de Fusão/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Anticorpos Monoclonais/genética
Anticorpos Monoclonais/metabolismo
Sítios de Ligação
Linhagem Celular
Cristalografia por Raios X
Enterovirus Humano A/genética
Enterovirus Humano A/crescimento & desenvolvimento
Enterovirus Humano A/imunologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/virologia
Expressão Gênica
Células HEK293
Seres Humanos
Fragmentos Fab das Imunoglobulinas/genética
Fragmentos Fab das Imunoglobulinas/metabolismo
Glicoproteínas de Membrana Associadas ao Lisossomo/genética
Glicoproteínas de Membrana Associadas ao Lisossomo/imunologia
Camundongos
Modelos Moleculares
Ligação Proteica
Conformação Proteica em alfa-Hélice
Conformação Proteica em Folha beta
Domínios e Motivos de Interação entre Proteínas
Receptores Depuradores/genética
Receptores Depuradores/imunologia
Receptores Virais/genética
Receptores Virais/imunologia
Proteínas Recombinantes de Fusão/genética
Proteínas Recombinantes de Fusão/imunologia
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Células Sf9
Spodoptera
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Immunoglobulin Fab Fragments); 0 (Lysosome-Associated Membrane Glycoproteins); 0 (Receptors, Scavenger); 0 (Receptors, Virus); 0 (Recombinant Fusion Proteins); 0 (SCARB2 protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1007/s13238-017-0405-7



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