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Pesquisa : D12.776.543.750.705.940.687 [Categoria DeCS]
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  1 / 11 MEDLINE  
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[PMID]:28867469
[Au] Autor:Kim SG; Jo YH; Seong JH; Park KB; Noh MY; Cho JH; Ko HJ; Kim CE; Tindwa H; Patnaik BB; Bang IS; Lee YS; Han YS
[Ad] Endereço:Division of Plant Biotechnology, Institute of Environmentally-Friendly Agriculture (IEFA), College of Agriculture and Life Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.
[Ti] Título:TmSR-C, scavenger receptor class C, plays a pivotal role in antifungal and antibacterial immunity in the coleopteran insect Tenebrio molitor.
[So] Source:Insect Biochem Mol Biol;89:31-42, 2017 Oct.
[Is] ISSN:1879-0240
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Scavenger receptors (SRs) constitute a family of membrane-bound receptors that bind to multiple ligands. The SR family of proteins is involved in removing cellular debris, oxidized low-density lipoproteins, and pathogens. Specifically, class C scavenger receptors (SR-C) have also been reported to be involved in phagocytosis of gram-positive and -negative bacteria in Drosophila and viruses in shrimp. However, reports are unavailable regarding the role of SR-C in antifungal immune mechanisms in insects. In this study, a full-length Tenebrio molitor SR-C (TmSR-C) sequence was obtained by 5'- and 3'-Rapid amplification of cDNA ends-polymerase chain reaction (RACE-PCR). The TmSR-C full-length cDNA comprised 1671 bp with 5'- and 3'-untranslated regions of 23- and 107-bp, respectively. TmSR-C encodes a putative protein of 556 amino acid residues that is constitutively expressed in all tissues of late instar larvae and 2-day-old adults, with the highest transcript levels observed in hemocytes of larvae and adults. TmSR-C mRNA showed a 2.5-fold and 3-fold increase at 24 and 6 h after infection with Candida albicans and ß-glucan, respectively. Immunoassay with TmSR-C polyclonal antibody showed induction of the putative protein in the cytosols of hemocytes at 3 h after inoculation of C. albicans. RNA interference (RNAi)-based gene silencing and phagocytosis assays were used to understand the role of TmSR-C in antifungal immunity. Silencing of TmSR-C transcripts reduced the survivability of late instar larvae at 2 days post-inoculation of C. albicans, Escherichia coli, or Staphylococcus aureus. Furthermore, in TmSR-C-silenced larvae, there was a decline in the rate of microorganism phagocytosis. Taken together, results of this study suggest that TmSR-C plays a pivotal role in phagocytosing not only fungi but also gram-negative and -positive bacteria in T. molitor.
[Mh] Termos MeSH primário: Fagocitose
Receptores Depuradores Classe C/fisiologia
Tenebrio/imunologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sequência de Bases
Candida albicans
Escherichia coli
Expressão Gênica
Hemócitos/metabolismo
Interferência de RNA
Análise de Sequência de DNA
Staphylococcus aureus
Tenebrio/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Scavenger Receptors, Class C)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


  2 / 11 MEDLINE  
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[PMID]:28027319
[Au] Autor:Yang MC; Shi XZ; Yang HT; Sun JJ; Xu L; Wang XW; Zhao XF; Wang JX
[Ad] Endereço:Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Jinan, Shandong, China.
[Ti] Título:Scavenger Receptor C Mediates Phagocytosis of White Spot Syndrome Virus and Restricts Virus Proliferation in Shrimp.
[So] Source:PLoS Pathog;12(12):e1006127, 2016 Dec.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scavenger receptors are an important class of pattern recognition receptors that play several important roles in host defense against pathogens. The class C scavenger receptors (SRCs) have only been identified in a few invertebrates, and their role in the immune response against viruses is seldom studied. In this study, we firstly identified an SRC from kuruma shrimp, Marsupenaeus japonicus, designated MjSRC, which was significantly upregulated after white spot syndrome virus (WSSV) challenge at the mRNA and protein levels in hemocytes. The quantity of WSSV increased in shrimp after knockdown of MjSRC, compared with the controls. Furthermore, overexpression of MjSRC led to enhanced WSSV elimination via phagocytosis by hemocytes. Pull-down and co-immunoprecipitation assays demonstrated the interaction between MjSRC and the WSSV envelope protein. Electron microscopy observation indicated that the colloidal gold-labeled extracellular domain of MjSRC was located on the outer surface of WSSV. MjSRC formed a trimer and was internalized into the cytoplasm after WSSV challenge, and the internalization was strongly inhibited after knockdown of Mjß-arrestin2. Further studies found that Mjß-arrestin2 interacted with the intracellular domain of MjSRC and induced the internalization of WSSV in a clathrin-dependent manner. WSSV were co-localized with lysosomes in hemocytes and the WSSV quantity in shrimp increased after injection of lysosome inhibitor, chloroquine. Collectively, this study demonstrated that MjSRC recognized WSSV via its extracellular domain and invoked hemocyte phagocytosis to restrict WSSV systemic infection. This is the first study to report an SRC as a pattern recognition receptor promoting phagocytosis of a virus.
[Mh] Termos MeSH primário: Penaeidae/imunologia
Penaeidae/virologia
Fagocitose/imunologia
Receptores Depuradores Classe C/imunologia
Replicação Viral/fisiologia
Vírus 1 da Síndrome da Mancha Branca
[Mh] Termos MeSH secundário: Animais
Perfilação da Expressão Gênica
Técnicas de Silenciamento de Genes
Imuno-Histoquímica
Imunoprecipitação
Microscopia Eletrônica de Transmissão
Receptores de Reconhecimento de Padrão/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Pattern Recognition); 0 (Scavenger Receptors, Class C)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006127


  3 / 11 MEDLINE  
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[PMID]:19269112
[Au] Autor:Jiang Y; Zhu J; Hu Y; Xing C; Li D; Hu B
[Ad] Endereço:Department of Ultrasound in Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, 600 Yishan Rd, Shanghai 200233, China.
[Ti] Título:Can scavenger receptor Class B Type I loaded ultrasound contrast agent be a new method for treating atherosclerosis?
[So] Source:Med Hypotheses;73(1):36-7, 2009 Jul.
[Is] ISSN:1532-2777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nowadays, Ultrasound contrast agent (UCA) is not only a good contrast agent for ultrasonic imaging, but also an important tool for drug delivery. As a kind of UCA, lipofectamine has the shell with positive charge. It can encapsulate genes and also be adhered to cells because genes and cells are all with negative charge. With this feature, it plays an important role in transfection. Scavenger Receptor Class B Type I(SR-BI) is a HDL receptor thought to be the first step in the progress of cholesterol transport. In this way, SR-BI loaded UCA has great possibility to cure atherosclerosis plaque.
[Mh] Termos MeSH primário: Aterosclerose/tratamento farmacológico
Meios de Contraste/uso terapêutico
Modelos Cardiovasculares
Receptores Depuradores Classe C/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Ultrassonografia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Scavenger Receptors, Class C)
[Em] Mês de entrada:0906
[Cu] Atualização por classe:090427
[Lr] Data última revisão:
090427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090310
[St] Status:MEDLINE
[do] DOI:10.1016/j.mehy.2009.01.043


  4 / 11 MEDLINE  
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[PMID]:17420244
[Au] Autor:Feinberg H; Taylor ME; Weis WI
[Ad] Endereço:Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94306, USA.
[Ti] Título:Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism.
[So] Source:J Biol Chem;282(23):17250-8, 2007 Jun 08.
[Is] ISSN:0021-9258
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The scavenger receptor C-type lectin (SRCL) is unique in the family of class A scavenger receptors, because in addition to binding sites for oxidized lipoproteins it also contains a C-type carbohydrate-recognition domain (CRD) that interacts with specific glycans. Both human and mouse SRCL are highly specific for the Lewis(x) trisaccharide, which is commonly found on the surfaces of leukocytes and some tumor cells. Structural analysis of the CRD of mouse SRCL in complex with Lewis(x) and mutagenesis show the basis for this specificity. The interaction between mouse SRCL and Lewis(x) is analogous to the way that selectins and DC-SIGN bind to related fucosylated glycans, but the mechanism of the interaction is novel, because it is based on a primary galactose-binding site similar to the binding site in the asialoglycoprotein receptor. Crystals of the human receptor lacking bound calcium ions reveal an alternative conformation in which a glycan ligand would be released during receptor-mediated endocytosis.
[Mh] Termos MeSH primário: Lectinas/metabolismo
Antígeno Lewis X/metabolismo
Receptores Depuradores Classe C/metabolismo
[Mh] Termos MeSH secundário: Animais
Cristalografia por Raios X
DNA Complementar
Lectinas/química
Lectinas/genética
Ligantes
Camundongos
Modelos Moleculares
Mutagênese Sítio-Dirigida
Ligação Proteica
Conformação Proteica
Receptores Depuradores Classe C/química
Receptores Depuradores Classe C/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (Lectins); 0 (Lewis X Antigen); 0 (Ligands); 0 (Scavenger Receptors, Class C)
[Em] Mês de entrada:0707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070411
[St] Status:MEDLINE


  5 / 11 MEDLINE  
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[PMID]:16670103
[Au] Autor:Coombs PJ; Taylor ME; Drickamer K
[Ad] Endereço:Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
[Ti] Título:Two categories of mammalian galactose-binding receptors distinguished by glycan array profiling.
[So] Source:Glycobiology;16(8):1C-7C, 2006 Aug.
[Is] ISSN:0959-6658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Profiling of the four known galactose-binding receptors in the C-type lectin family has been undertaken in parallel on a glycan array. The results are generally consistent with those of previous assays using various different formats, but they provide a direct comparison of the properties of the four receptors, revealing that they fall into two distinct groups. The major subunit of the rat asialoglycoprotein receptor and the rat Kupffer cell receptor show similar broad preferences for GalNAc-terminated glycans, while the rat macrophage galactose lectin and the human scavenger receptor C-type lectin (SRCL) bind more restricted sets of glycans. Both of these receptors bind to Lewis x-type structures, but the macrophage galactose lectin also interacts strongly with biantennary galactose- and GalNAc-terminated glycans. Although the similar glycan-binding profiles for the asialoglycoprotein receptor and the Kupffer cell receptor might suggest that these receptors are functionally redundant, analysis of fibroblasts transfected with full-length Kupffer cell receptor reveals that they fail to endocytose glycosylated ligand.
[Mh] Termos MeSH primário: Receptor de Asialoglicoproteína/química
Receptor de Asialoglicoproteína/metabolismo
Galactose/metabolismo
Polissacarídeos/química
Receptores de Superfície Celular/química
Receptores de Superfície Celular/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sítios de Ligação
Linhagem Celular
DNA Complementar
Fibroblastos/metabolismo
Fucose/química
Galactose/química
Seres Humanos
Ligantes
Macrófagos/química
Dados de Sequência Molecular
Ligação Proteica
Estrutura Terciária de Proteína
Ratos
Receptores Depuradores Classe C/química
Receptores Depuradores Classe C/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Asialoglycoprotein Receptor); 0 (DNA, Complementary); 0 (Ligands); 0 (Polysaccharides); 0 (Receptors, Cell Surface); 0 (Scavenger Receptors, Class C); 28RYY2IV3F (Fucose); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:0609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060504
[St] Status:MEDLINE


  6 / 11 MEDLINE  
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[PMID]:15716507
[Au] Autor:Lazzaro BP
[Ad] Endereço:Department of Entomology, Cornell University, Ithaca, New York 14853, USA. BL89@cornell.edu
[Ti] Título:Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans.
[So] Source:Genetics;169(4):2023-34, 2005 Apr.
[Is] ISSN:0016-6731
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scavenger receptor proteins are involved in the cellular internalization of a broad variety of foreign material, including pathogenic bacteria during phagocytosis. I find here that nonsynonymous divergence in three class C scavenger receptors (Sr-C's) between Drosophila melanogaster and D. simulans and between each of these species and D. yakuba is approximately four times the typical genome average. These genes also exhibit unusually high levels of segregating nonsynonymous polymorphism in D. melanogaster and D. simulans populations. A fourth Sr-C is comparatively conserved. McDonald-Kreitman tests reveal a significant excess of replacement fixations between D. melanogaster and D. simulans in the Sr-C's, but tests of polymorphic site frequency spectra do not support models of directional selection. It is possible that the molecular functions of SR-C proteins are sufficiently robust to allow exceptionally high amino acid substitution rates without compromising organismal fitness. Alternatively, SR-Cs may evolve under diversifying selection, perhaps as a result of pressure from pathogens. Interestingly, Sr-CIII and Sr-CIV are polymorphic for premature stop codons. Sr-CIV is also polymorphic for an in-frame 101-codon deletion and for the absence of one intron.
[Mh] Termos MeSH primário: Drosophila melanogaster/genética
Drosophila/genética
Polimorfismo Genético
Receptores Imunológicos/genética
Receptores Imunológicos/fisiologia
[Mh] Termos MeSH secundário: Animais
Códon
Códon de Terminação
Evolução Molecular
Deleção de Genes
Variação Genética
Genoma
Íntrons
Desequilíbrio de Ligação
Modelos Genéticos
Modelos Estatísticos
Dados de Sequência Molecular
Mutação
Fagocitose
Receptores Depuradores
Receptores Depuradores Classe C
Análise de Sequência de DNA
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Codon); 0 (Codon, Terminator); 0 (Receptors, Immunologic); 0 (Receptors, Scavenger); 0 (Scavenger Receptors, Class C)
[Em] Mês de entrada:0508
[Cu] Atualização por classe:170219
[Lr] Data última revisão:
170219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050218
[St] Status:MEDLINE


  7 / 11 MEDLINE  
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[PMID]:11754822
[Au] Autor:Rämet M; Pearson A; Manfruelli P; Li X; Koziel H; Göbel V; Chung E; Krieger M; Ezekowitz RA
[Ad] Endereço:Laboratory of Developmental Immunology, MassGeneral Hospital for Children, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA. mramet@partners.org
[Ti] Título:Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria.
[So] Source:Immunity;15(6):1027-38, 2001 Dec.
[Is] ISSN:1074-7613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One hallmark of innate immunity apparently conserved from primitive life forms through to humans is the ability of the host to recognize pathogen-associated molecular patterns (PAMPs). Since macrophage pattern recognition receptors are not well defined in Drosophila, we set out to identify such receptors. Our findings reveal that Drosophila macrophages express multiple pattern recognition receptors and that the Drosophila scavenger receptor, dSR-CI, is one such receptor capable of recognizing both gram-negative and gram-positive bacteria, but not yeast. Our data indicate that scavenger receptor bacterial recognition is conserved from insects to humans and may represent one of the most primitive forms of microbial recognition.
[Mh] Termos MeSH primário: Proteínas de Drosophila/fisiologia
Drosophila melanogaster/fisiologia
Bactérias Gram-Negativas/metabolismo
Bactérias Gram-Positivas/metabolismo
Macrófagos/fisiologia
Receptores Imunológicos/fisiologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Células CHO
Células COS
Candida/metabolismo
Células Cultivadas/microbiologia
Células Cultivadas/fisiologia
Cercopithecus aethiops
Cricetinae
Cricetulus
Drosophila melanogaster/embriologia
Drosophila melanogaster/microbiologia
Escherichia coli/metabolismo
Evolução Molecular
Proteínas de Insetos/biossíntese
Proteínas de Insetos/genética
Macrófagos/efeitos dos fármacos
Macrófagos/microbiologia
Dados de Sequência Molecular
Fagocitose/efeitos dos fármacos
Polimorfismo Genético
Receptores Depuradores
Proteínas Recombinantes de Fusão/biossíntese
Receptores Depuradores Classe C
Especificidade da Espécie
Staphylococcus aureus/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Attacin-A protein, Drosophila); 0 (Attacin-B protein, Drosophila); 0 (Attacin-C protein, Drosophila); 0 (Drosophila Proteins); 0 (Insect Proteins); 0 (Receptors, Immunologic); 0 (Receptors, Scavenger); 0 (Recombinant Fusion Proteins); 0 (Scavenger Receptors, Class C); 0 (Sr-CI protein, Drosophila); 0 (attacin antibacterial protein, insect)
[Em] Mês de entrada:0201
[Cu] Atualização por classe:071114
[Lr] Data última revisão:
071114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020105
[St] Status:MEDLINE


  8 / 11 MEDLINE  
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[PMID]:11351611
[Au] Autor:Ueda Y
[Ad] Endereço:Shiga Medical Center, Research Institute.
[Ti] Título:[Scavenger receptor class C type I (SR-CI)].
[So] Source:Nihon Rinsho;59 Suppl 2:377-8, 2001 Feb.
[Is] ISSN:0047-1852
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Receptores Imunológicos/química
Receptores Imunológicos/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Receptores Depuradores
Receptores Depuradores Classe C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Immunologic); 0 (Receptors, Scavenger); 0 (Scavenger Receptors, Class C)
[Em] Mês de entrada:0109
[Cu] Atualização por classe:110727
[Lr] Data última revisão:
110727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010516
[St] Status:MEDLINE


  9 / 11 MEDLINE  
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[PMID]:9990422
[Au] Autor:Kyaw Y; Hasegawa G; Takatsuka H; Shimada-Hiratsuka M; Umezu H; Arakawa M; Naito M
[Ad] Endereço:Second Department of Pathology, Niigata University School of Medicine, Japan. 2byori@med.niigata-u.ac.jp
[Ti] Título:Expression of macrophage colony-stimulating factor, scavenger receptors, and macrophage proliferation in the pregnant mouse uterus.
[So] Source:Arch Histol Cytol;61(5):383-93, 1998 Dec.
[Is] ISSN:0914-9465
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:During pregnancy, mouse uterine epithelial cells produce and secrete a large amount of macrophage colony-stimulating factor (M-CSF/CSF-1). Macrophages accumulate and proliferate in the undecidualized endometrium of the pregnant uterus. Observations showed that macrophages expressed scavenger receptor class A (type I and type II) and class C (macrosialin). Scavenger receptors appeared to be involved in the removal of apoptotic cells in the degenerated decidual tissue. The expression of class A and class C scavenger receptor mRNAs in the uterus of pregnant mice was elevated but the expression of class B scavenger receptor (CD36) mRNA was similar to that of non-pregnant mice. The expression of various cytokines and chemokines, including M-CSF, monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1-alpha), was enhanced in the uterus of pregnant mice, suggesting that these molecules regulate macrophage chemotaxis and immunological function in the uterus. These findings imply that the pregnant uterus provides a microenvironment for the recruitment, differentiation, and proliferation of macrophages and the regulation of scavenger receptor and cytokine expression for a successful pregnancy.
[Mh] Termos MeSH primário: Divisão Celular
Fator Estimulador de Colônias de Macrófagos/genética
Macrófagos/citologia
Proteínas de Membrana
Receptores Imunológicos/genética
Receptores de Lipoproteínas
Útero/metabolismo
[Mh] Termos MeSH secundário: Animais
Apoptose
Antígenos CD36
Quimiocina CCL2/genética
Quimiocina CCL3
Quimiocina CCL4
Endométrio/metabolismo
Células Epiteliais/metabolismo
Feminino
Imuno-Histoquímica
Hibridização In Situ
Proteínas Inflamatórias de Macrófagos/genética
Camundongos
Camundongos Endogâmicos BALB C
Gravidez
RNA Mensageiro/metabolismo
Receptores Depuradores
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Receptores Depuradores Classe A
Receptores Depuradores Classe B
Receptores Depuradores Classe C
Útero/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CD36 Antigens); 0 (Chemokine CCL2); 0 (Chemokine CCL3); 0 (Chemokine CCL4); 0 (Macrophage Inflammatory Proteins); 0 (Membrane Proteins); 0 (RNA, Messenger); 0 (Receptors, Immunologic); 0 (Receptors, Lipoprotein); 0 (Receptors, Scavenger); 0 (Scarb1 protein, mouse); 0 (Scavenger Receptors, Class A); 0 (Scavenger Receptors, Class B); 0 (Scavenger Receptors, Class C); 81627-83-0 (Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:9902
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:990217
[St] Status:MEDLINE


  10 / 11 MEDLINE  
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[PMID]:7732030
[Au] Autor:Pearson A; Lux A; Krieger M
[Ad] Endereço:Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
[Ti] Título:Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster.
[So] Source:Proc Natl Acad Sci U S A;92(9):4056-60, 1995 Apr 25.
[Is] ISSN:0027-8424
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mammalian class A macrophage-specific scavenger receptors (SR-A) exhibit unusually broad binding specificity for a wide variety of polyanionic ligands. The properties of these receptors suggest that they may be involved in atherosclerosis and host defense. We have previously observed a similar receptor activity in Drosophila melanogaster embryonic macrophages and in the Drosophila macrophage-like Schneider L2 cell line. Expression cloning was used to isolate from L2 cells a cDNA that encodes a third class (class C) of scavenger receptor, Drosophila SR-CI (dSR-CI). dSR-CI expression was restricted to macrophages/hemocytes during embryonic development. When expressed in mammalian cells, dSR-CI exhibited high affinity and saturable binding of 125I-labeled acetylated low density lipoprotein and mediated its chloroquine-dependent, presumably lysosomal, degradation. Although the broad polyanionic ligand-binding specificity of dSR-CI was similar to that of SR-A, their predicted protein sequences are not similar. dSR-CI is a 609-residue type I integral membrane protein containing several well-known sequence motifs, including two complement control protein (CCP) domains and somatomedin B, MAM, and mucin-like domains. Macrophage scavenger receptors apparently mediate important, well-conserved functions and may be pattern-recognition receptors that arose early in the evolution of host-defense mechanisms. Genetic and physiologic analysis of dSR-CI function in Drosophila should provide further insights into the roles played by scavenger receptors in host defense and development.
[Mh] Termos MeSH primário: Drosophila melanogaster/imunologia
Macrófagos/imunologia
Proteínas de Membrana
Receptores Imunológicos/metabolismo
Receptores de Lipoproteínas
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Evolução Biológica
Células CHO
Clonagem Molecular
Sequência Consenso
Cricetinae
Proteínas de Drosophila
Drosophila melanogaster/embriologia
Drosophila melanogaster/genética
Embrião não Mamífero/imunologia
Expressão Gênica
Hibridização In Situ
Cinética
Lipoproteínas LDL/metabolismo
Dados de Sequência Molecular
Receptores Imunológicos/biossíntese
Receptores Depuradores
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/metabolismo
Receptores Depuradores Classe A
Receptores Depuradores Classe B
Receptores Depuradores Classe C
Homologia de Sequência de Aminoácidos
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Lipoproteins, LDL); 0 (Membrane Proteins); 0 (Receptors, Immunologic); 0 (Receptors, Lipoprotein); 0 (Receptors, Scavenger); 0 (Recombinant Proteins); 0 (Scarb1 protein, mouse); 0 (Scavenger Receptors, Class A); 0 (Scavenger Receptors, Class B); 0 (Scavenger Receptors, Class C); 0 (Sr-CI protein, Drosophila); 0 (Sr-CIII protein, Drosophila); 0 (acetyl-LDL)
[Em] Mês de entrada:9506
[Cu] Atualização por classe:170219
[Lr] Data última revisão:
170219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950425
[St] Status:MEDLINE



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