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[PMID]:18822328
[Au] Autor:Wiederholt T; von Westernhagen M; Zaldivar MM; Berres ML; Schmitz P; Hellerbrand C; Müller T; Berg T; Trautwein C; Wasmuth HE
[Ad] Endereço:Department of Dermatology, University Hospital Aachen, Aachen, Germany.
[Ti] Título:Genetic variations of the chemokine scavenger receptor D6 are associated with liver inflammation in chronic hepatitis C.
[So] Source:Hum Immunol;69(12):861-6, 2008 Dec.
[Is] ISSN:0198-8859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic hepatitis C (HCV) represents one of the most common chronic infections worldwide and is a major indication for liver transplantation. Liver inflammation is the main predictor of advanced fibrosis in HCV. Inflammatory cells are recruited to the liver by chemokines. Recently, a novel class of chemokine receptors has been characterized that lack signaling functions and are termed scavenger receptors. We determine here whether genetic variations of the scavenger receptor D6 contribute to the grade of liver inflammation in HCV. Four haplotype tagging single nucleotide polymorphisms (SNPs) were identified from HapMap that cover the genetic information of D6 (CCBP2). Among these SNPs, rs4683336 was associated with liver inflammation in qualitative (p = 0.003) and quantitative (p = 0.0086) genotype analysis. This association was confirmed in an independent cohort of HCV-infected patients (p = 0.006 for qualitative and p = 0.0046 for quantitative analysis, respectively). Furthermore, the haplotype that is tagged by marker rs4683336 was significantly correlated with liver inflammation when compared with the most common D6 haplotype (p = 0.014). The importance of genetic variations in D6 was supported through the demonstration of an association of D6 mRNA expression with histologic inflammation in liver biopsies and a considerable range of D6 mRNA expression in isolated human hepatocytes. In conclusion, we demonstrate that variations in a chemokine scavenging receptor are significantly correlated with clinical inflammatory phenotypes such as HCV infection.
[Mh] Termos MeSH primário: Hepacivirus/imunologia
Hepatite C Crônica/genética
Hepatite C Crônica/imunologia
Hepatócitos/metabolismo
RNA Mensageiro/análise
Receptores de Quimiocinas/imunologia
Receptores Depuradores Classe D/genética
Receptores Depuradores Classe D/imunologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/análise
Células Cultivadas
Análise Mutacional de DNA
Feminino
Predisposição Genética para Doença
Hepatite C Crônica/complicações
Hepatite C Crônica/diagnóstico
Hepatite C Crônica/fisiopatologia
Hepatócitos/imunologia
Seres Humanos
Cirrose Hepática/etiologia
Cirrose Hepática/genética
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
Prognóstico
Receptores de Quimiocinas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (CCBP2 protein, human); 0 (RNA, Messenger); 0 (Receptors, Chemokine); 0 (Scavenger Receptors, Class D)
[Em] Mês de entrada:0903
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080930
[St] Status:MEDLINE
[do] DOI:10.1016/j.humimm.2008.08.275


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[PMID]:14661091
[Au] Autor:Horiuchi S; Sakamoto Y; Sakai M
[Ad] Endereço:Department of Medical Biochemistry, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan. Horiuchi@gpo.kumamoto-u.ac.jp
[Ti] Título:Scavenger receptors for oxidized and glycated proteins.
[So] Source:Amino Acids;25(3-4):283-92, 2003 Dec.
[Is] ISSN:0939-4451
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Our present knowledge on chemically modified proteins and their receptor systems is originated from a proposal by Goldstein and Brown in 1979 for the receptor for acetylated LDL which is involved in foam cell formation, one of critical steps in atherogenesis. Subsequent extensive studies using oxidized LDL (OxLDL) as a representative ligand disclosed at least 11 different scavenger receptors which are collectively categorized as "scavenger receptor family". Advanced glycation endproducts (AGE) and their receptor systems have been studied independently until recent findings that AGE-proteins are also recognized as active ligands by scavenger receptors including class A scavenger receptor (SR-A), class B scavenger receptors such as CD36 and SR-BI, type D scavenger receptor (LOX-1) and FEEL-1/FEEL-2. Three messages can be summarized from these experiments; (i) endocytic uptake of OxLDL and AGE-proteins by macrophages or macrophage-derived cells is mainly mediated by SR-A and CD36, which is an important step for foam cell formation in the early stage of atherosclerosis, (ii) selective uptake of cholesteryl esters of high density lipoprotein (HDL) mediated by SR-BI is inhibited by AGE-proteins, suggesting a potential pathological role of AGE in a HDL-mediated reverse cholesterol transport system, (iii) a novel scavenger receptor is involved in hepatic clearance of plasma OxLDL and AGE-proteins.
[Mh] Termos MeSH primário: Proteínas/metabolismo
Receptores de Superfície Celular/metabolismo
Receptores Imunológicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Antígenos CD36
Produtos Finais de Glicação Avançada/metabolismo
Seres Humanos
Ligantes
Lipoproteínas HDL/metabolismo
Lipoproteínas LDL/metabolismo
Modelos Biológicos
Oxirredução
Proteínas/química
Receptores Imunológicos/classificação
Receptores Depuradores
Receptores Depuradores Classe A
Receptores Depuradores Classe B
Receptores Depuradores Classe D
Receptores Depuradores Classe E
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (CD36 Antigens); 0 (Glycation End Products, Advanced); 0 (Ligands); 0 (Lipoproteins, HDL); 0 (Lipoproteins, LDL); 0 (Proteins); 0 (Receptors, Cell Surface); 0 (Receptors, Immunologic); 0 (Receptors, Scavenger); 0 (SCARB1 protein, human); 0 (Scavenger Receptors, Class A); 0 (Scavenger Receptors, Class B); 0 (Scavenger Receptors, Class D); 0 (Scavenger Receptors, Class E); 0 (oxidized low density lipoprotein)
[Em] Mês de entrada:0408
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031209
[St] Status:MEDLINE


  3 / 3 MEDLINE  
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[PMID]:11753207
[Au] Autor:van Oosten M; van Amersfoort ES; van Berkel TJ; Kuiper J
[Ad] Endereço:Division of Biopharmaceutics, Sylvius Laboratory, Leiden/Amsterdam Center for Drug Research, University of Leiden, Leiden, The Netherlands.
[Ti] Título:Scavenger receptor-like receptors for the binding of lipopolysaccharide and lipoteichoic acid to liver endothelial and Kupffer cells.
[So] Source:J Endotoxin Res;7(5):381-4, 2001.
[Is] ISSN:0968-0519
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was undertaken to identify the role of scavenger receptors in the catabolism of lipopolysaccharide (LPS) and lipoteichoic acid (LTA). LPS is mainly cleared from the blood by the liver. The Kupffer cells are primarily responsible for this clearance. Although several binding sites have been described for LPS and LTA, only CD14 is involved in LPS signalling. Scavenger receptor type A (SR-A) is expressed in the liver on endothelial cells and Kupffer cells, and macrosialin (class D scavenger receptor) is expressed on Kupffer cells. Fucoidin and poly-I are both good inhibitors of scavenger receptors. Fucoidin significantly reduced the serum clearance of [125I]-LPS and decreased liver uptake of [125I]-LPS by approximately 40%. Poly-I inhibited the binding of [125I]-LPS to isolated Kupffer and endothelial cells by 75%, while poly-A, a polyanionic substrate that does not block scavenger receptors, had no effect. LPS significantly inhibited the binding of acetylated LDL and oxidized LDL (two well-described scavenger receptor ligands) to isolated Kupffer and liver endothelial cells. OxLDL and acLDL did not affect the binding of LPS to these cells. We conclude that on both endothelial cells and Kupffer cells, LPS mainly binds to scavenger receptors, but SR-A and macrosialin contribute to a limited extent to the binding of LPS. Injection of LTA into C57Bl6 mice resulted in a maximal liver uptake of 20% of the injected dose. In the liver, 50% was bound by the Kupffer cells, 20% by parenchymal cells and 30% by liver endothelial cells. The contribution of SR-A to the plasma clearance of LTA was limited. A main component in the catabolism of LTA is the interaction of LTA with plasma lipoproteins, which limit the uptake of LTA by tissues and extend the plasma half-life of LTA.
[Mh] Termos MeSH primário: Endotélio Vascular/metabolismo
Macrófagos do Fígado/metabolismo
Lipopolissacarídeos/farmacocinética
Fígado/irrigação sanguínea
Proteínas de Membrana
Receptores Imunológicos/metabolismo
Receptores de Lipoproteínas
Ácidos Teicoicos/farmacocinética
[Mh] Termos MeSH secundário: Animais
Radioisótopos do Iodo
Fígado/metabolismo
Camundongos
Poli A/farmacologia
Poli I/farmacologia
Polissacarídeos/farmacologia
Ratos
Receptores Imunológicos/antagonistas & inibidores
Receptores Imunológicos/classificação
Receptores Depuradores
Salmonella/imunologia
Receptores Depuradores Classe A
Receptores Depuradores Classe B
Receptores Depuradores Classe D
Staphylococcus aureus/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Lipopolysaccharides); 0 (Membrane Proteins); 0 (Polysaccharides); 0 (Receptors, Immunologic); 0 (Receptors, Lipoprotein); 0 (Receptors, Scavenger); 0 (Scarb1 protein, mouse); 0 (Scavenger Receptors, Class A); 0 (Scavenger Receptors, Class B); 0 (Scavenger Receptors, Class D); 0 (Teichoic Acids); 24937-83-5 (Poly A); 25249-22-3 (Poly I); 56411-57-5 (lipoteichoic acid); 9072-19-9 (fucoidan)
[Em] Mês de entrada:0203
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:011226
[St] Status:MEDLINE



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