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[PMID]:28300612
[Au] Autor:Cui L; Lv C; Zhang J; Mo C; Lin D; Li J; Wang Y
[Ad] Endereço:Key laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, PR China.
[Ti] Título:Characterization of melanin-concentrating hormone (MCH) and its receptor in chickens: Tissue expression, functional analysis, and fasting-induced up-regulation of hypothalamic MCH expression.
[So] Source:Gene;615:57-67, 2017 Jun 05.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Melanin-concentrating hormone (MCH) is a neuropeptide expressed in the brain and exerts its actions through interaction with the two known G protein-coupled receptors, namely melanin-concentrating hormone receptor 1 and 2 (MCHR1 and MCHR2) in mammals. However, the information regarding the expression and functionality of MCH and MCHR(s) remains largely unknown in birds. In this study, using RT-PCR and RACE PCR, we amplified and cloned a MCHR1-like receptor, which is named cMCHR4 according to its evolutionary origin, and a MCHR2 from chicken brain. The cloned cMCHR4 was predicted to encode a receptor of 367 amino acids, which shares high amino acid identities with MCHR4 of ducks (90%), western painted turtles (85%), and coelacanths (77%), and a comparatively low identity to human MCHR1 (58%) and MCHR2 (38%), whereas chicken MCHR2 encodes a putative C-terminally truncated receptor and is likely a pseudogene. Using cell-based luciferase reporter assays or Western blot, we further demonstrated that chicken (and duck) MCHR4 could be potently activated by chicken MCH , and its activation can elevate calcium concentration and activate MAPK/ERK and cAMP/PKA signaling pathways, indicating an important role of MCHR4 in mediating MCH actions in birds. Quantitative real-time PCR revealed that both cMCH and cMCHR4 mRNA are expressed in various brain regions including the hypothalamus, and cMCH expression in the hypothalamus of 3-week-old chicks could be induced by 36-h fasting, indicating that cMCH expression is correlated with energy balance. Taken together, characterization of chicken MCH and MCHR4 will aid to uncover the conserved roles of MCH across vertebrates.
[Mh] Termos MeSH primário: Galinhas/genética
Hormônios Hipotalâmicos/genética
Hipotálamo/metabolismo
Melaninas/genética
Hormônios Hipofisários/genética
Receptores do Hormônio Hipofisário/genética
[Mh] Termos MeSH secundário: Animais
Clonagem Molecular
Patos/genética
Jejum
Regulação da Expressão Gênica
Células HEK293
Seres Humanos
Hormônios Hipotalâmicos/metabolismo
Melaninas/metabolismo
Hormônios Hipofisários/metabolismo
Receptores do Hormônio Hipofisário/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypothalamic Hormones); 0 (Melanins); 0 (Pituitary Hormones); 0 (Receptors, Pituitary Hormone); 0 (melanin-concentrating hormone receptor); 67382-96-1 (melanin-concentrating hormone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


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[PMID]:27986627
[Au] Autor:Kawata Y; Okuda S; Hotta N; Igawa H; Takahashi M; Ikoma M; Kasai S; Ando A; Satomi Y; Nishida M; Nakayama M; Yamamoto S; Nagisa Y; Takekawa S
[Ad] Endereço:Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: yayoi.kawata@takeda.com.
[Ti] Título:A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models.
[So] Source:Eur J Pharmacol;796:45-53, 2017 Feb 05.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Melanin-concentrating hormone (MCH), a cyclic neuropeptide expressed predominantly in the lateral hypothalamus, plays an important role in the control of feeding behavior and energy homeostasis. Mice lacking MCH or MCH receptor are resistant to diet-induced obesity (DIO) and MCH receptor antagonists show potent anti-obesity effects in preclinical studies, indicating that MCH receptor is a promising target for anti-obesity drugs. Moreover, recent studies have suggested the potential of MCH receptor antagonists for treatment of non-alcoholic fatty liver disease (NAFLD). In the present study, we show the anti-obesity and anti-hepatosteatosis effect of our novel MCH receptor antagonist, Compound A. Repeated oral administration of Compound A resulted in dose-dependent body weight reduction and had an anorectic effect in DIO mice. The body weight lowering effect of Compound A was more potent than that of pair-feeding. Compound A also reduced lipid content and the expression level of lipogenesis-, inflammation-, and fibrosis-related genes in the liver of DIO mice. Conversely, intracerebroventricular infusion of MCH caused induction of hepatic steatosis as well as increase in body weight in high-fat diet-fed wild type mice, but not MCH receptor knockout mice. The pair-feeding study revealed the MCH-MCH receptor system affects hepatic steatosis through a mechanism that is independent of body weight change. Metabolome analysis demonstrated that Compound A upregulated lipid metabolism-related molecules, such as acylcarnitines and cardiolipins, in the liver. These findings suggest that our novel MCH receptor antagonist, Compound A, exerts its beneficial therapeutic effect on NAFLD and obesity through a central MCH-MCH receptor pathway.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/farmacologia
Dieta Hiperlipídica/efeitos adversos
Hepatopatia Gordurosa não Alcoólica/induzido quimicamente
Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico
Obesidade/induzido quimicamente
Obesidade/tratamento farmacológico
Receptores do Hormônio Hipofisário/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Fármacos Antiobesidade/uso terapêutico
Peso Corporal/efeitos dos fármacos
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Técnicas de Inativação de Genes
Lipogênese/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Hepatopatia Gordurosa não Alcoólica/metabolismo
Obesidade/metabolismo
Ratos
Receptores do Hormônio Hipofisário/deficiência
Receptores do Hormônio Hipofisário/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Receptors, Pituitary Hormone); 0 (melanin-concentrating hormone receptor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE


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[PMID]:27195455
[Au] Autor:Sclafani A; Adamantidis A; Ackroff K
[Ad] Endereço:Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY, USA; Behavioral and Cognitive Neuroscience Cluster, Psychology Doctoral Program, The Graduate School, City University of New York, New York, NY, USA.
[Ti] Título:MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice.
[So] Source:Physiol Behav;163:239-244, 2016 Sep 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The post-oral actions of glucose stimulate intake and condition flavor preferences in rodents. Hypothalamic melanin-concentrating hormone (MCH) neurons are implicated in sugar reward, and this study investigated their involvement in glucose preference conditioning in mice. In Exp. 1 MCH receptor 1 knockout (KO) and C57BL/6 wildtype (WT) mice learned to prefer 8% glucose over an initially more-preferred non-nutritive 0.1% sucralose+saccharin (S+S) solution. In contrast, the KO and WT mice preferred S+S to 8% fructose, which is consistent with this sugar's weak post-oral reinforcing action. In Exp. 2 KO and WT mice were trained to drink a flavored solution (CS+) paired with intragastric (IG) infusion of 16% glucose and a different flavored solution (CS-) paired with IG water. Both groups drank more CS+ than CS- in training and preferred the CS+ to CS- in a 2-bottle test. These results indicate that MCH receptor signaling is not required for flavor preferences conditioned by the post-oral actions of glucose. This contrasts with other findings implicating MCH signaling in other types of sugar reward processing.
[Mh] Termos MeSH primário: Condicionamento Clássico/fisiologia
Preferências Alimentares/fisiologia
Glucose/administração & dosagem
Receptores do Hormônio Hipofisário/deficiência
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Receptores do Hormônio Hipofisário/genética
Sacarina/administração & dosagem
Edulcorantes
Paladar/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Pituitary Hormone); 0 (Sweetening Agents); 0 (melanin-concentrating hormone receptor); FST467XS7D (Saccharin); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160520
[St] Status:MEDLINE


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[PMID]:27193719
[Au] Autor:Novosadova EV; Manuilova ES; Arsenyeva EL; Andreeva LA; Lebedeva OS; Grivennikov IA; Myasoedov NF
[Ad] Endereço:Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia. novek-img@mail.ru.
[Ti] Título:Investigation of the effect of α-melanocyte-stimulating hormone on proliferation and early stages of differentiation of human induced pluripotent stem cells.
[So] Source:Dokl Biochem Biophys;467(1):141-4, 2016 Mar.
[Is] ISSN:1608-3091
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:We have studied the influence of α-melanocyte-stimulating hormone (α-MSH) on proliferation and early stages of differentiation of human induced pluripotent stem cells (iPSc). We have demonstrated that α-MSH receptor genes are expressed in undifferentiated iPSc. The expression levels of MCR1, MCR2, and MCR3 increased at the embryoid body (EB) formation stage. The formation of neural progenitors was accompanied by elevation of MCR2, MCR3, and MCR4 expression. α-MSH had no effect on EB generation and iPSc proliferation at concentrations ranging from 1 nM to 10 µM. At the same time, α-MSH increased the generation of neural rosettes in human iPSc cultures more than twice.
[Mh] Termos MeSH primário: Diferenciação Celular/fisiologia
Proliferação Celular/fisiologia
Células-Tronco Pluripotentes Induzidas/fisiologia
alfa-MSH/metabolismo
[Mh] Termos MeSH secundário: Células Cultivadas
Relação Dose-Resposta a Droga
Expressão Gênica/fisiologia
Seres Humanos
Células-Tronco Neurais/fisiologia
Neurônios/fisiologia
Receptores do Hormônio Hipofisário/metabolismo
alfa-MSH/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MSH receptor); 0 (Receptors, Pituitary Hormone); 581-05-5 (alpha-MSH)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160520
[St] Status:MEDLINE
[do] DOI:10.1134/S1607672916020174


  5 / 1016 MEDLINE  
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[PMID]:26701888
[Au] Autor:Abdelbaset-Ismail A; Borkowska S; Janowska-Wieczorek A; Tonn T; Rodriguez C; Moniuszko M; Bolkun L; Koloczko J; Eljaszewicz A; Ratajczak J; Ratajczak MZ; Kucia M
[Ad] Endereço:Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, KY, USA.
[Ti] Título:Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells.
[So] Source:Oncotarget;7(3):3033-46, 2016 Jan 19.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We recently reported that normal hematopoietic stem cells express functional pituitary sex hormone (SexH) receptors. Here we report for the first time that pituitary-secreted gonadotrophins stimulate migration, adhesion, and proliferation of several human myeloid and lymphoid leukemia cell lines. Similar effects were observed after stimulation of human leukemic cell lines by gonadal SexHs. This effect seems to be direct, as the SexH receptors expressed by leukemic cells responded to stimulation by phosphorylation of MAPKp42/44 and AKTser473. Furthermore, in parallel studies we confirmed that human primary patient-derived AML and CML blasts also express several functional SexH receptors. These results shed more light on the potential role of SexHs in leukemogenesis and, in addition, provide further evidence suggesting a developmental link between hematopoiesis and the germline.
[Mh] Termos MeSH primário: Hormônio Foliculoestimulante/farmacologia
Gonadotropinas Hipofisárias/metabolismo
Leucemia Mielogênica Crônica BCR-ABL Positiva/metabolismo
Leucemia Mieloide Aguda/metabolismo
Hormônio Luteinizante/farmacologia
Receptores do Hormônio Hipofisário/metabolismo
[Mh] Termos MeSH secundário: Adesão Celular/fisiologia
Linhagem Celular Tumoral
Movimento Celular/fisiologia
Proliferação Celular/fisiologia
Seres Humanos
Células Jurkat
Proteínas Quinases Ativadas por Mitógeno/metabolismo
Células Mieloides/metabolismo
Fosforilação
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gonadotropins, Pituitary); 0 (Receptors, Pituitary Hormone); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151225
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.6698


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[PMID]:26545301
[Au] Autor:Masunari K; Cline MA; Khan SI; Tachibana T
[Ad] Endereço:Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States.
[Ti] Título:Feeding response following central administration of mesotocin and arginine-vasotocin receptor agonists in chicks (Gallus gallus).
[So] Source:Physiol Behav;153:149-54, 2016 Jan 01.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mesotocin (MT) and arginine-vasotocin (AVT) are posterior pituitary derived hormones in birds and are homologous to mammalian oxytocin (OT) and vasopressin (VP), respectively. We previously reported that intracerebroventricular (ICV) injection of both MT and AVT inhibit feeding and induce wing-flapping in chicks (Gallus gallus). Because both peptides cause similar effects suggests that they might act via common receptors. However, the specific receptors of MT and AVT which mediate their anorexigenic effect have not been clarified in chicks. Thus, the purpose of the present study was to identify the receptor subtypes involved in MT- and AVT-induced anorexia and behavioral patterns by using several agonists. ICV injection of vasopressin-1 receptor agonist (V1R) (homologous to chicken AVT receptor-2 and -4 [VT2R and VT4R, respectively]), significantly decreased food intake while agonists of vasopressin-2 receptor (V2R) and OT receptor (OTR) (homologues of chicken AVT receptor-1 and MT receptor respectively) had no effect. In addition, V1R agonist induced wing-flapping although this was not affected by V2R or OTR agonists. Since VT2R has not been found in the brain of chicks, the present study suggested that VT4R might be related to the anorexigenic effect and wing-flapping induced by MT and AVT in chicks.
[Mh] Termos MeSH primário: Desamino Arginina Vasopressina/farmacologia
Ingestão de Alimentos/efeitos dos fármacos
Ocitocina/análogos & derivados
Receptores do Hormônio Hipofisário/agonistas
Receptores de Vasopressinas/agonistas
[Mh] Termos MeSH secundário: Animais
Galinhas
Desamino Arginina Vasopressina/administração & dosagem
Desamino Arginina Vasopressina/análogos & derivados
Injeções Intraventriculares
Masculino
Ocitocina/administração & dosagem
Ocitocina/agonistas
Ocitocina/farmacologia
Asas de Animais/efeitos dos fármacos
Asas de Animais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Pituitary Hormone); 0 (Receptors, Vasopressin); 0 (mesotocin receptor); 0 (vasotocin receptor); 2480-41-3 (oxytocin, Phe(2)-Orn(8)-); 3Y635KQT1J (mesotocin); 50-56-6 (Oxytocin); 60786-59-6 (oxytocin, Thr(4)-Gly(7)-); ENR1LLB0FP (Deamino Arginine Vasopressin)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151108
[St] Status:MEDLINE


  7 / 1016 MEDLINE  
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[PMID]:26548314
[Au] Autor:Day FR; Bulik-Sullivan B; Hinds DA; Finucane HK; Murabito JM; Tung JY; Ong KK; Perry JR
[Ad] Endereço:MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
[Ti] Título:Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.
[So] Source:Nat Commun;6:8842, 2015 Nov 09.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Understanding of the genetic regulation of puberty timing has come largely from studies of rare disorders and population-based studies in women. Here, we report the largest genomic analysis for puberty timing in 55,871 men, based on recalled age at voice breaking. Analysis across all genomic variants reveals strong genetic correlation (0.74, P=2.7 × 10(-70)) between male and female puberty timing. However, some loci show sex-divergent effects, including directionally opposite effects between sexes at the SIM1/MCHR2 locus (Pheterogeneity=1.6 × 10(-12)). We find five novel loci for puberty timing (P<5 × 10(-8)), in addition to nine signals in men that were previously reported in women. Newly implicated genes include two retinoic acid-related receptors, RORB and RXRA, and two genes reportedly disrupted in rare disorders of puberty, LEPR and KAL1. Finally, we identify genetic correlations that indicate shared aetiologies in both sexes between puberty timing and body mass index, fasting insulin levels, lipid levels, type 2 diabetes and cardiovascular disease.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/genética
Diabetes Mellitus Tipo 2/genética
Síndrome do Ovário Policístico/genética
Puberdade/genética
[Mh] Termos MeSH secundário: Adolescente
Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética
Estatura/genética
Índice de Massa Corporal
Densidade Óssea/genética
Criança
HDL-Colesterol/sangue
Grupo com Ancestrais do Continente Europeu/genética
Proteínas da Matriz Extracelular/genética
Feminino
Estudo de Associação Genômica Ampla
Seres Humanos
Insulina/sangue
Vértebras Lombares/diagnóstico por imagem
Masculino
Proteínas do Tecido Nervoso/genética
Membro 2 do Grupo F da Subfamília 1 de Receptores Nucleares/genética
Radiografia
Receptores Acoplados a Proteínas-G/genética
Receptores para Leptina/genética
Receptores do Hormônio Hipofisário/genética
Proteínas Repressoras/genética
Receptor X Retinoide alfa/genética
Fatores Sexuais
Fatores de Tempo
Triglicerídeos/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Transcription Factors); 0 (Cholesterol, HDL); 0 (Extracellular Matrix Proteins); 0 (Insulin); 0 (KAL1 protein, human); 0 (MCHR2 protein, human); 0 (Nerve Tissue Proteins); 0 (Nuclear Receptor Subfamily 1, Group F, Member 2); 0 (RORB protein, human); 0 (Receptors, G-Protein-Coupled); 0 (Receptors, Leptin); 0 (Receptors, Pituitary Hormone); 0 (Repressor Proteins); 0 (Retinoid X Receptor alpha); 0 (SIM1 protein, human); 0 (Triglycerides); 0 (leptin receptor, human)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151110
[St] Status:MEDLINE
[do] DOI:10.1038/ncomms9842


  8 / 1016 MEDLINE  
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[PMID]:26461262
[Au] Autor:Delacrétaz A; Preisig M; Vandenberghe F; Saigi Morgui N; Quteineh L; Choong E; Gholam-Rezaee M; Kutalik Z; Magistretti P; Aubry JM; von Gunten A; Castelao E; Vollenweider P; Waeber G; Conus P; Eap CB
[Ad] Endereço:Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.
[Ti] Título:Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.
[So] Source:PLoS One;10(10):e0139155, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population. The influence of MCHR2 and MCHR2-AS1 tSNPs on BMI was firstly investigated in a discovery psychiatric sample (n1 = 474). Positive results were tested for replication in two other psychiatric samples (n2 = 164, n3 = 178) and in two population-based samples (CoLaus, n4 = 5409; GIANT, n5 = 113809). In the discovery sample, TT carriers of rs7754794C>T had 1.08 kg/m2 (p = 0.04) lower BMI as compared to C-allele carriers. This observation was replicated in an independent psychiatric sample (-2.18 kg/m2; p = 0.009). The association of rs7754794C>T and BMI seemed stronger in subjects younger than 45 years (median of age). In the population-based sample, a moderate association was observed (-0.17 kg/m2; p = 0.02) among younger individuals (<45y). Interestingly, this association was totally driven by patients meeting lifetime criteria for atypical depression, i.e. major depressive episodes characterized by symptoms such as an increased appetite. Indeed, patients with atypical depression carrying rs7754794-TT had 1.17 kg/m2 (p = 0.04) lower BMI values as compared to C-allele carriers, the effect being stronger in younger individuals (-2.50 kg/m2; p = 0.03; interaction between rs7754794 and age: p-value = 0.08). This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression.
[Mh] Termos MeSH primário: Índice de Massa Corporal
Depressão/genética
Transtornos Mentais/genética
Polimorfismo de Nucleotídeo Único/genética
RNA Longo não Codificante/genética
Receptores Acoplados a Proteínas-G/genética
Receptores do Hormônio Hipofisário/genética
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Europeu/genética
Estudos de Associação Genética
Predisposição Genética para Doença
Haplótipos/genética
Seres Humanos
Meia-Idade
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (MCHR2 protein, human); 0 (MCHR2-AS1 long non-coding RNA, human); 0 (RNA, Long Noncoding); 0 (Receptors, G-Protein-Coupled); 0 (Receptors, Pituitary Hormone)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0139155


  9 / 1016 MEDLINE  
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[PMID]:25425529
[Au] Autor:Lema SC; Sanders KE; Walti KA
[Ad] Endereço:Biological Sciences Department, Center for Coastal Marine Sciences, California Polytechnic State University, San Luis Obispo, CA, USA.
[Ti] Título:Arginine vasotocin, isotocin and nonapeptide receptor gene expression link to social status and aggression in sex-dependent patterns.
[So] Source:J Neuroendocrinol;27(2):142-57, 2015 Feb.
[Is] ISSN:1365-2826
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nonapeptide hormones of the vasopressin/oxytocin family regulate social behaviours. In mammals and birds, variation in behaviour also is linked to expression patterns of the V1a-type receptor and the oxytocin/mesotocin receptor in the brain. Genome duplications, however, expand the diversity of nonapeptide receptors in actinopterygian fishes, and two distinct V1a-type receptors (v1a1 and v1a2) for vasotocin, as well as at least two V2-type receptors (v2a and v2b), have been identified in these taxa. The present study investigates how aggression connected to social status relates to the abundance patterns of gene transcripts encoding four vasotocin receptors, an isotocin receptor (itr), pro-vasotocin (proVT) and pro-isotocin (proIT) in the brain of the pupfish Cyprinodon nevadensis amargosae. Sexually-mature pupfish were maintained in mixed-sex social groups and assessed for individual variation in aggressive behaviours. Males in these groups behaved more aggressively than females, and larger fish exhibited higher aggression relative to smaller fish of the same sex. Hypothalamic proVT transcript abundance was elevated in dominant males compared to subordinate males, and correlated positively with individual variation in aggression in both social classes. Transcripts encoding vasotocin receptor v1a1 were at higher levels in the telencephalon and hypothalamus of socially subordinate males than dominant males. Dominant males exhibited elevated hypothalamic v1a2 receptor transcript abundance relative to subordinate males and females, and telencephalic v1a2 mRNA abundance in dominant males was also associated positively with individual aggressiveness. Transcripts in the telencephalon encoding itr were elevated in females relative to males, and both telencephalic proIT and hypothalamic itr transcript abundance varied with female social status. Taken together, these data link hypothalamic proVT expression to aggression and implicate forebrain expression of the V1a-type receptor v1a2 as potentially mediating the effects of vasotocin on behaviour in male fish. These findings also illustrate how associations between social status, aggression and gene expression within the VT and IT nonapeptide systems can be contingent on behavioural context.
[Mh] Termos MeSH primário: Agressão/fisiologia
Expressão Gênica/fisiologia
Hierarquia Social
Receptores de Ocitocina/metabolismo
Receptores do Hormônio Hipofisário/metabolismo
Receptores de Vasopressinas/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Dados de Sequência Molecular
RNA Mensageiro/metabolismo
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Receptors, Oxytocin); 0 (Receptors, Pituitary Hormone); 0 (Receptors, Vasopressin); 0 (mesotocin receptor); 0 (vasotocin receptor)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150127
[Lr] Data última revisão:
150127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141127
[St] Status:MEDLINE
[do] DOI:10.1111/jne.12239


  10 / 1016 MEDLINE  
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[PMID]:24662390
[Au] Autor:Kobayashi Y; Hamamoto A; Hirayama T; Saito Y
[Ad] Endereço:Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-hiroshima, Hiroshima 739-8521, Japan.
[Ti] Título:Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis.
[So] Source:Gen Comp Endocrinol;212:114-23, 2015 Feb 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Melanin-concentrating hormone (MCH) mainly regulates feeding in mammals and pigmentation in teleosts. It acts via two G-protein-coupled receptors, MCH receptor 1 (MCHR1) and MCHR2. Although many studies exploring the MCH system in teleosts and mammals have been carried out, studies on other organisms are limited. In this study, we cloned and characterized four MCHR subtypes from the diploid species Xenopus tropicalis (X-MCHRs; X-MCHR1a, R1b, R2a, and R2b). According to a phylogenetic tree of the X-MCHRs, X-MCHR1a and R2a are close to mammalian MCHRs, while X-MCHR1b and R2b are close to teleostean MCHRs. We previously reported that the G-protein coupling capacity of the MCHR subtypes differed between mammals (R1: Gαi/o and Gαq; R2: Gαq) and teleosts (R1: Gαq; R2: Gαi/o and Gαq) in mammalian cell-based assays. By using Ca(2+) mobilization assays with pertussis toxin in CHO dhfr(-) cells, we found that X-MCHR1a promiscuously coupled to both Gαi/o and Gαq, while X-MCHR1b and R2a exclusively coupled to Gαq. However, no Ca(2+) influx was detected in cells transfected with X-MCHR2b. Reverse transcription-PCR showed that the X-MCHR mRNAs were expressed in various tissues. In particular, both X-MCHR1b and R2b were exclusively found in melanophores of the dorsal skin. In skin pigment migration assays, melanophores were weakly aggregated at low concentrations but dispersed at high concentrations of MCH, suggesting possible interactions between X-MCHR1b and R2b for the regulation of body color. These findings demonstrate that X. tropicalis has four characteristic MCHRs and will be useful for elucidating the nature of MCHR evolution among vertebrates.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica
Hormônios Hipotalâmicos/genética
Melaninas/genética
Hormônios Hipofisários/genética
Receptores do Hormônio Hipofisário/genética
Transdução de Sinais
Xenopus/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Western Blotting
Células CHO
Cálcio/metabolismo
Clonagem Molecular
Cricetulus
Hormônios Hipotalâmicos/metabolismo
Melaninas/metabolismo
Melanóforos/metabolismo
Dados de Sequência Molecular
Filogenia
Hormônios Hipofisários/metabolismo
RNA Mensageiro/genética
Reação em Cadeia da Polimerase em Tempo Real
Receptores do Hormônio Hipofisário/metabolismo
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Homologia de Sequência de Aminoácidos
Pele/metabolismo
Xenopus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypothalamic Hormones); 0 (Melanins); 0 (Pituitary Hormones); 0 (RNA, Messenger); 0 (Receptors, Pituitary Hormone); 0 (melanin-concentrating hormone receptor); 67382-96-1 (melanin-concentrating hormone); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:150327
[Lr] Data última revisão:
150327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140326
[St] Status:MEDLINE



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