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[PMID]: 29362889 [Au] Autor: Gaudio F; Tamma R; Ingravallo G; Perrone T; Laddaga FE; De Candia M; Maiorano E; Ribatti D; Specchia G [Ad] Endereço: Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari, Italy. fragaudio@alice.it. [Ti] Título: Computer-driven quantitative image analysis in the assessment of tumor cell and T cell features in diffuse large B cell lymphomas. [So] Source: Ann Hematol;97(4):663-668, 2018 Apr. [Is] ISSN: 1432-0584 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Diffuse large B cell lymphoma (DLBCL) is recognized as the most common non-Hodgkin lymphoma subtype. Advanced high-resolution digital scans of pathology slides have enabled the development of computer-based image analysis algorithms that may assist pathologists in quantifying immunohistochemical stains. In this retrospective study, we reviewed data from 29 patients affected by DLBCL. In order to evaluate the number of tumor cells and microenvironment T cells, we performed an analysis of CD20, Ki67, and CD3 counts, assessed with the Positive Pixel Count algorithm embedded in the Aperio ImageScope software. A lower tumor cell count was observed in patients with a non-germinal center immunophenotype, high LDH, splenomegaly and an IPI ≥ 3. A lower number of CD3 was observed in patients with bulky disease, an IPI ≥ 3 and disease stage 3-4. Overall, these data confirm that quantitative analysis of the tumor cells and of the tumor microenvironment by means of computer-driven quantitative image analysis may add new information in DLBCL diagnosis. [Mh] Termos MeSH primário: Linfócitos B/patologia Interpretação de Imagem Assistida por Computador Linfonodos/diagnóstico por imagem Linfoma Difuso de Grandes Células B/diagnóstico por imagem Linfócitos T/patologia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Algoritmos Antígenos CD20/metabolismo Linfócitos B/imunologia Linfócitos B/metabolismo Complexo CD3/metabolismo Feminino Centro Germinativo/imunologia Centro Germinativo/metabolismo Centro Germinativo/patologia Seres Humanos Imuno-Histoquímica Antígeno Ki-67/metabolismo Linfonodos/imunologia Linfonodos/metabolismo Linfonodos/patologia Linfoma Difuso de Grandes Células B/imunologia Linfoma Difuso de Grandes Células B/metabolismo Linfoma Difuso de Grandes Células B/patologia Masculino Meia-Idade Estadiamento de Neoplasias Prognóstico Estudos Retrospectivos Linfócitos T/imunologia Linfócitos T/metabolismo Microambiente Tumoral [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antigens, CD20); 0 (CD3 Complex); 0 (Ki-67 Antigen) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180125 [St] Status: MEDLINE [do] DOI: 10.1007/s00277-017-3212-6

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[PMID]: 29330228 [Au] Autor: McCormack A; Dekkers OM; Petersenn S; Popovic V; Trouillas J; Raverot G; Burman P; ESE survey collaborators [Ad] Endereço: St Vincent's Hospital and Garvan Institute of Medical ResearchSydney, Australia. [Ti] Título: Treatment of aggressive pituitary tumours and carcinomas: results of a European Society of Endocrinology (ESE) survey 2016. [So] Source: Eur J Endocrinol;178(3):265-276, 2018 03. [Is] ISSN: 1479-683X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To collect outcome data in a large cohort of patients with aggressive pituitary tumours (APT)/carcinomas (PC) and specifically report effects of temozolomide (TMZ) treatment. DESIGN: Electronic survey to ESE members Dec 2015-Nov 2016. RESULTS: Reports on 166 patients (40 PC, 125 APT, 1 unclassified) were obtained. Median age at diagnosis was 43 (range 4-79) years. 69% of the tumours were clinically functioning, and the most frequent immunohistochemical subtype were corticotroph tumours (45%). Ki-67 index did not distinguish APT from PC, median 7% and 10% respectively. TMZ was first-line chemotherapy in 157 patients. At the end of the treatment (median 9 cycles), radiological evaluation showed complete response (CR) in 6%, partial response (PR) in 31%, stable disease (SD) in 33% and progressive disease in 30%. Response was more frequent in patients receiving concomitant radiotherapy and TMZ. CR was seen only in patients with low MGMT expression. Clinically functioning tumours were more likely to respond than non-functioning tumours, independent of MGMT status. Of patients with CR, PR and SD, 25, 40 and 48% respectively progressed after a median of 12-month follow-up. Other oncological drugs given as primary treatment and to TMZ failures resulted in PR in 20%. CONCLUSION: This survey confirms that TMZ is established as first-line chemotherapeutic treatment of APT/PC. Clinically functioning tumours, low MGMT and concurrent radiotherapy were associated with a better response. The limited long-term effect of TMZ and the poor efficacy of other drugs highlight the need to identify additional effective therapies. [Mh] Termos MeSH primário: Adenoma/terapia Antineoplásicos Alquilantes/uso terapêutico Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico Carcinoma/terapia Irradiação Craniana Dacarbazina/análogos & derivados Procedimentos Neurocirúrgicos Neoplasias Hipofisárias/terapia [Mh] Termos MeSH secundário: Adenoma/metabolismo Adenoma/patologia Adolescente Adulto Idoso Bevacizumab/administração & dosagem Capecitabina/administração & dosagem Carcinoma/metabolismo Carcinoma/patologia Carmustina/administração & dosagem Criança Pré-Escolar Metilases de Modificação do DNA/metabolismo Enzimas Reparadoras do DNA/metabolismo Dacarbazina/administração & dosagem Dacarbazina/uso terapêutico Endocrinologia Europa (Continente) Feminino Seres Humanos Antígeno Ki-67/metabolismo Masculino Meia-Idade Invasividade Neoplásica Neoplasias Hipofisárias/metabolismo Neoplasias Hipofisárias/patologia Sociedades Médicas Inquéritos e Questionários Talidomida/administração & dosagem Proteínas Supressoras de Tumor/metabolismo Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents, Alkylating); 0 (Ki-67 Antigen); 0 (Tumor Suppressor Proteins); 2S9ZZM9Q9V (Bevacizumab); 4Z8R6ORS6L (Thalidomide); 6804DJ8Z9U (Capecitabine); 7GR28W0FJI (Dacarbazine); EC 2.1.1.- (DNA Modification Methylases); EC 2.1.1.63 (MGMT protein, human); EC 6.5.1.- (DNA Repair Enzymes); U68WG3173Y (Carmustine); YF1K15M17Y (temozolomide) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180114 [St] Status: MEDLINE [do] DOI: 10.1530/EJE-17-0933

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[PMID]: 28470951 [Au] Autor: Posso M; Corominas JM; Serrano L; Román M; Torá-Rocamora I; Domingo L; Romero A; Quintana MJ; Vernet-Tomas M; Baré M; Vidal C; Sánchez M; Saladié F; Natal C; Ferrer J; Servitja S; Sala M; Castells X; BELE Study Group [Ad] Endereço: Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. [Ti] Título: Biomarkers expression in benign breast diseases and risk of subsequent breast cancer: a case-control study. [So] Source: Cancer Med;6(6):1482-1489, 2017 Jun. [Is] ISSN: 2045-7634 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Women with benign breast diseases (BBD) have a high risk of breast cancer. However, no biomarkers have been clearly established to predict cancer in these women. Our aim was to explore whether estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression stratify risk of breast cancer in screened women with BBD. We conducted a nested case-control study. Women with breast cancer and prior BBDs (86 cases) were matched to women with prior BBDs who were free from breast cancer (172 controls). The matching factors were age at BBD diagnosis, type of BBD, and follow-up time since BBD diagnosis. ER, PR, and Ki67 expression were obtained from BBDs' specimens. Conditional logistic regression was used to estimate odds ratios (ORs), and 95% confidence intervals (CIs) of breast cancer risk according to ER, PR, and Ki67 expression. Women with >90% of ER expression had a higher risk of breast cancer (OR = 2.63; 95% CI: 1.26-5.51) than women with ≤70% of ER expression. Similarly, women with >80% of PR expression had a higher risk of breast cancer (OR = 2.22; 95% CI: 1.15-4.27) than women with ≤40% of PR expression. Women with proliferative disease and ≥1% of Ki67 expression had a nonsignificantly increased risk of breast cancer (OR = 1.16; 95% CI: 0.46-2.90) than women with <1% of Ki67 expression. A high expression of ER and PR in BBD is associated with an increased risk of subsequent breast cancer. In proliferative disease, high Ki67 expression may also have an increased risk. This information is helpful to better characterize BBD and is one more step toward personalizing the clinical management of these women. [Mh] Termos MeSH primário: Doenças Mamárias/epidemiologia Doenças Mamárias/metabolismo Receptores Estrogênicos/metabolismo Receptores de Progesterona/metabolismo [Mh] Termos MeSH secundário: Idoso Biomarcadores/metabolismo Mama/metabolismo Estudos de Casos e Controles Feminino Seres Humanos Antígeno Ki-67/metabolismo Meia-Idade Razão de Chances Fatores de Risco Espanha/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Ki-67 Antigen); 0 (Receptors, Estrogen); 0 (Receptors, Progesterone) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1002/cam4.1080

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[PMID]: 27775692 [Au] Autor: Aeffner F; Martin NT; Peljto M; Black JC; Major JK; Jangani M; Ports MO; Krueger JS; Young GD [Ad] Endereço: Flagship Biosciences Inc., Westminster, CO, USA. [Ti] Título: Quantitative assessment of pancreatic cancer precursor lesions in IHC-stained tissue with a tissue image analysis platform. [So] Source: Lab Invest;96(12):1327-1336, 2016 12. [Is] ISSN: 1530-0307 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Tissue image analysis (tIA) is emerging as a powerful tool for quantifying biomarker expression and distribution in complex diseases and tissues. Pancreatic ductal adenocarcinoma (PDAC) develops in a highly complex and heterogeneous tissue environment and, generally, has a very poor prognosis. Early detection of PDAC is confounded by limited knowledge of the pre-neoplastic disease stages and limited methods to quantitatively assess disease heterogeneity. We sought to develop a tIA approach to assess the most common PDAC precursor lesions, pancreatic intraepithelial neoplasia (PanIN), in tissues from Kras ; Trp53 ; Pdx-Cre (KPC) mice, a validated model of PDAC development. tIA profiling of training regions of PanIN and tumor microenvironment (TME) cells was utilized to guide identification of PanIN/TME tissue compartment stratification criteria. A custom CellMap algorithm implementing these criteria was applied to whole-slide images of KPC mice pancreata sections to quantify p53 and Ki-67 biomarker staining in each tissue compartment as a proof-of-concept for the algorithm platform. The algorithm robustly identified a higher percentage of p53-positive cells in PanIN lesions relative to the TME, whereas no difference was observed for Ki-67. Ki-67 expression was also quantified in a human pancreatic tissue sample available to demonstrate the translatability of the CellMap algorithm to human samples. Together, our data demonstrated the utility of CellMap to enable objective and quantitative assessments, across entire tissue sections, of PDAC precursor lesions in preclinical and clinical models of this disease to support efforts leading to novel insights into disease progression, diagnostic markers, and potential therapeutic targets. [Mh] Termos MeSH primário: Adenocarcinoma in Situ/diagnóstico Carcinoma Ductal Pancreático/diagnóstico Pâncreas/patologia Neoplasias Pancreáticas/diagnóstico Lesões Pré-Cancerosas/diagnóstico Proteína Supressora de Tumor p53/metabolismo [Mh] Termos MeSH secundário: Adenocarcinoma in Situ/diagnóstico por imagem Adenocarcinoma in Situ/metabolismo Adenocarcinoma in Situ/patologia Algoritmos Animais Automação Laboratorial Carcinoma Ductal Pancreático/diagnóstico por imagem Carcinoma Ductal Pancreático/metabolismo Carcinoma Ductal Pancreático/patologia Cruzamentos Genéticos Modelos Animais de Doenças Detecção Precoce de Câncer/métodos Seres Humanos Processamento de Imagem Assistida por Computador Imuno-Histoquímica Antígeno Ki-67/metabolismo Camundongos Mutantes Camundongos Transgênicos Pâncreas/metabolismo Neoplasias Pancreáticas/diagnóstico por imagem Neoplasias Pancreáticas/metabolismo Neoplasias Pancreáticas/patologia Lesões Pré-Cancerosas/diagnóstico por imagem Lesões Pré-Cancerosas/metabolismo Lesões Pré-Cancerosas/patologia Software Organismos Livres de Patógenos Específicos Bancos de Tecidos Ultrassonografia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ki-67 Antigen); 0 (Tumor Suppressor Protein p53) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE [do] DOI: 10.1038/labinvest.2016.111

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[PMID]: 29248134 [Au] Autor: Monti D; Sotgia F; Whitaker-Menezes D; Tuluc M; Birbe R; Berger A; Lazar M; Cotzia P; Draganova-Tacheva R; Lin Z; Domingo-Vidal M; Newberg A; Lisanti MP; Martinez-Outschoorn U [Ad] Endereço: Marcus Institute of Integrative Health at Thomas Jefferson University, Philadelphia, PA. [Ti] Título: Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. [So] Source: Semin Oncol;44(3):226-232, 2017 06. [Is] ISSN: 1532-8708 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: High oxidative stress as defined by hydroxyl and peroxyl activity is often found in the stroma of human breast cancers. Oxidative stress induces stromal catabolism, which promotes cancer aggressiveness. Stromal cells exposed to oxidative stress release catabolites such as lactate, which are up-taken by cancer cells to support mitochondrial oxidative phosphorylation. The transfer of catabolites between stromal and cancer cells leads to metabolic heterogeneity between these cells and increased cancer cell proliferation and reduced apoptosis in preclinical models. N-Acetylcysteine (NAC) is an antioxidant that reduces oxidative stress and reverses stromal catabolism and stromal-carcinoma cell metabolic heterogeneity, resulting in reduced proliferation and increased apoptosis of cancer cells in experimental models of breast cancer. The purpose of this clinical trial was to determine if NAC could reduce markers of stromal-cancer metabolic heterogeneity and markers of cancer cell aggressiveness in human breast cancer. METHODS: Subjects with newly diagnosed stage 0 and I breast cancer who were not going to receive neoadjuvant therapy prior to surgical resection were treated with NAC before definitive surgery to assess intra-tumoral metabolic markers. NAC was administered once a week intravenously at a dose of 150 mg/kg and 600 mg twice daily orally on the days not receiving intravenous NAC. Histochemistry for the stromal metabolic markers monocarboxylate transporter 4 (MCT4) and caveolin-1 (CAV1) and the Ki67 proliferation assay and TUNEL apoptosis assay in carcinoma cells were performed in pre- and post-NAC specimens. RESULTS: The range of days on NAC was 14-27 and the mean was 19 days. Post-treatment biopsies showed significant decrease in stromal MCT4 and reduced Ki67 in carcinoma cells. NAC did not significantly change stromal CAV1 and carcinoma TUNEL staining. NAC was well tolerated. CONCLUSIONS: NAC as a single agent reduces MCT4 stromal expression, which is a marker of glycolysis in breast cancer with reduced carcinoma cell proliferation. This study suggests that modulating metabolism in the tumor microenvironment has the potential to impact breast cancer proliferation. [Mh] Termos MeSH primário: Acetilcisteína/uso terapêutico Neoplasias da Mama/tratamento farmacológico Carcinoma Ductal de Mama/tratamento farmacológico Carcinoma Intraductal não Infiltrante/tratamento farmacológico Depuradores de Radicais Livres/uso terapêutico Mastectomia [Mh] Termos MeSH secundário: Adulto Apoptose Neoplasias da Mama/metabolismo Neoplasias da Mama/patologia Carcinoma Ductal de Mama/metabolismo Carcinoma Ductal de Mama/patologia Carcinoma Intraductal não Infiltrante/metabolismo Carcinoma Intraductal não Infiltrante/patologia Carcinoma Papilar/tratamento farmacológico Carcinoma Papilar/metabolismo Carcinoma Papilar/patologia Caveolina 1/metabolismo Proliferação Celular Feminino Seres Humanos Imuno-Histoquímica Marcação In Situ das Extremidades Cortadas Antígeno Ki-67/metabolismo Meia-Idade Transportadores de Ácidos Monocarboxílicos/metabolismo Proteínas Musculares/metabolismo Terapia Neoadjuvante Estadiamento de Neoplasias Projetos Piloto Células Estromais/metabolismo Resultado do Tratamento Microambiente Tumoral [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nome de substância: 0 (CAV1 protein, human); 0 (Caveolin 1); 0 (Free Radical Scavengers); 0 (Ki-67 Antigen); 0 (Monocarboxylic Acid Transporters); 0 (Muscle Proteins); 0 (SLC16A4 protein, human); WYQ7N0BPYC (Acetylcysteine) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 180222 [Lr] Data última revisão: 180222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171218 [St] Status: MEDLINE

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[PMID]: 28456778 [Au] Autor: Rhone P; Ruszkowska-Ciastek B; Celmer M; Brkic A; Bielawski K; Boinska J; Zarychta E; Rosc D [Ad] Endereço: Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University w Torun, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland. ruszkowska.basia@gmail.com. [Ti] Título: Increased number of endothelial progenitors in peripheral blood as a possible early marker of tumour growth in post-menopausal breast cancer patients. [So] Source: J Physiol Pharmacol;68(1):139-148, 2017 Feb. [Is] ISSN: 1899-1505 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: The aim of the study was to evaluate the number of circulating endothelial progenitor cells (circulating EPCs) in the blood of patients diagnosed with breast cancer and to make an attempt at finding associations with the number of circulating EPCs and selected clinic-pathological factors; TNM and histological grading, molecular subtype of breast cancer, hormonal status, the expression of Ki-67 and the size of tumour. The study involved 96 Caucasian ethnicity post-menopausal women. Sixty-six women aged 48 - 63 (mean age 55) with breast cancer diagnosis without distant metastases (M0). The median value of the tumour diameter was 1.51 cm. The control group consisted of 30 healthy, non-smoking, post-menopausal women, mean age 49, range 44 - 54 years of age. The exclusion criteria for all the participants were hypertension, hyperlipidaemia, and hyperglycaemia, acute and chronic infection. With regard to the fresh blood samples the number of circulating endothelial progenitors was determined using flow cytometry. The fluorescence of 100,000 cells was measured during the analysis. Circulating EPCs were identified with the immune-phenotype CD45 , CD34 , CD133 , CD31 . A significantly higher number of circulating EPCs in the study group, as compared to the controls (P = 0.0001) and a significantly higher number of circulating EPCs in women over 60 with breast cancer than in the younger women (P = 0.0029) were reported. A positive correlation was noted between circulating EPCs and age as well as between circulating EPCs and HER-2 (P = 0.0231, P = 0.0414, respectively), and a negative correlation between circulating EPCs and histological grading of breast cancer (P = 0.0272). The study has shown a higher number of circulating EPCs in breast cancer patients, which indicates stimulation of neovascularization. Additionally, since bone morrow-derived circulating EPCs are more intensively mobilised in older and overweight breast cancer patients, we can speculate that more aggressive neo-angiogenesis can occur in those patients. [Mh] Termos MeSH primário: Neoplasias da Mama/patologia Células Progenitoras Endoteliais/patologia [Mh] Termos MeSH secundário: Adulto Antígenos CD/imunologia Neoplasias da Mama/imunologia Neoplasias da Mama/metabolismo Feminino Seres Humanos Antígeno Ki-67/metabolismo Meia-Idade Neovascularização Patológica Pós-Menopausa Carga Tumoral [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antigens, CD); 0 (Ki-67 Antigen) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170501 [St] Status: MEDLINE

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[PMID]: 29390540 [Au] Autor: Tao M; Chen S; Zhang X; Zhou Q [Ad] Endereço: Fuling Center Hospital of Chongqing City. [Ti] Título: Ki-67 labeling index is a predictive marker for a pathological complete response to neoadjuvant chemotherapy in breast cancer: A meta-analysis. [So] Source: Medicine (Baltimore);96(51):e9384, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: A pathological complete response (pCR) after neoadjuvant chemotherapy (NCT) is a strong indicator of the benefit of therapy and presents an early surrogate for a favorable long-term outcome. It remains unclear whether Ki-67, a marker for tumor proliferation, can function as a predictor of the response to NCT in breast cancer. The objective of this meta-analysis was to compare the pCR rate and clinical outcomes in breast cancer patients with different Ki-67 labeling indexes (Ki-67 LI) who received NCT. METHODS: Clinical studies were retrieved from the electronic databases of PubMed, Embase, Clinical Trials, Wanfang, and the Chinese National Knowledge Infrastructure, from their inception to July 31, 2017. Meta-analysis was performed on pool eligible studies to determine whether Ki-67 LI was associated with the pCR rate and clinical outcomes of breast cancer patients who were treated with NCT. Pooled analyses were performed using fixed effects models. Two reviewers screened all titles and abstracts and independently assessed all articles. RESULTS: A total of 36 studies involving 6793 patients were included in the meta-analysis. Pooled analysis results revealed that patients with high Ki-67 LI exhibited significantly higher pCR rates (odds ratio [OR] = 3.94, 95% confidence interval [CI]: 3.33-4.67, P <.001) but poorer relapse-free survival (OR = 1.99, 95% CI: 1.39-2.85, P <.001) than those with low Ki-67 LI, but there was no significant difference in objective tumor response rate. CONCLUSION: The meta-analysis reported here demonstrates that pretherapeutic Ki-67 LI is associated with pCR in breast cancer patients undergoing NCT. More phase III randomized clinical trials will be required to confirm our findings. [Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico Neoplasias da Mama/tratamento farmacológico Neoplasias da Mama/patologia Antígeno Ki-67/metabolismo Mastectomia Terapia Neoadjuvante [Mh] Termos MeSH secundário: Neoplasias da Mama/metabolismo Neoplasias da Mama/cirurgia Quimioterapia Adjuvante Feminino Seres Humanos Modelos Estatísticos Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Ki-67 Antigen) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180214 [Lr] Data última revisão: 180214 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009384

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[PMID]: 29365416 [Au] Autor: Zhang JJ; Yang XT; Du XS; Zhang JX; Hou LN; Niu JL [Ad] Endereço: Department of MR&CT, Shanxi cancer hospital, Taiyuan 030013, China. [Ti] Título: [MRI findings and pathological features of occult breast cancer]. [So] Source: Zhonghua Zhong Liu Za Zhi;40(1):40-45, 2018 Jan 23. [Is] ISSN: 0253-3766 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: To investigate the magnetic resonance imaging (MRI) findings and clinicopathological features of primary lesions in patients with occult breast cancer (OBC). The imaging reports from the Breast Imaging Reporting and Data System in 2013 were retrospectively analyzed to investigate the morphology and the time signal intensity curve (TIC) of breast lesions in patients with OBC. The clinical and pathological characteristics of these patients were also included. A total of 34 patients were enrolled. Among these patients, 24 patients underwent modified radical mastectomy and 18 of them had primary breast carcinoma in pathological sections. MRI detected 17 cases of primary lesions, including six masse lesions with a diameter of 0.6-1.2 cm (average 0.9 cm), and 11 non-mass lesions with four linear distributions, three segmental distributions, three focal distributions, and one regions distribution. Five patients had TIC typeâ… primary lesions, ten had TIC type â…¡ primary lesions, and two had TIC type â…¢ primary lesions. Among all 34 cases, 23 of them had complete results of immunohistochemistry: 11 estrogen receptor (ER) positive lesions (47.8%), tenprogesterone receptor (PR) positive lesions (43.5%), seven human epidermal growth factor receptor 2 (HER-2) positive lesions (30.4%), and 20high expression(>14%) of Ki-67 (87.0%). The proportion of type luminal A was 4.3%, type luminal B was 43.5%, triple negative breast cancer (TNBC) was 30.4%, and HER-2 over expression accounted for 21.7%. The primary lesions of OBC usually manifested as small mass lesions, or focal, linear or segmental distribution of non-mass lesions. The positive rate of ER and PR was low, but the positive rate of HER-2 and the proliferation index of Ki-67 was high. Type luminal B is the most common molecular subtype. [Mh] Termos MeSH primário: Neoplasias da Mama/patologia [Mh] Termos MeSH secundário: Adulto Mama/química Mama/diagnóstico por imagem Mama/patologia Neoplasias da Mama/química Neoplasias da Mama/diagnóstico por imagem Neoplasias da Mama/cirurgia Feminino Seres Humanos Imuno-Histoquímica Antígeno Ki-67/análise Imagem por Ressonância Magnética Mastectomia Radical Modificada Meia-Idade Neoplasias Primárias Desconhecidas/química Neoplasias Primárias Desconhecidas/diagnóstico por imagem Neoplasias Primárias Desconhecidas/patologia Neoplasias Primárias Desconhecidas/cirurgia Receptor ErbB-2/análise Receptores Estrogênicos/análise Receptores de Progesterona/análise Estudos Retrospectivos Carga Tumoral [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ki-67 Antigen); 0 (Receptors, Estrogen); 0 (Receptors, Progesterone); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (Receptor, ErbB-2) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180212 [Lr] Data última revisão: 180212 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180125 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.0253-3766.2018.01.007

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[PMID]: 29374696 [Au] Autor: Glatzel-Plucinska N; Piotrowska A; Grzegrzolka J; Olbromski M; Rzechonek A; Dziegiel P; Podhorska-Okolow M [Ad] Endereço: Department of Histology and Embryology, Medical University, Wroclaw, Poland. [Ti] Título: SATB1 Level Correlates with Ki-67 Expression and Is a Positive Prognostic Factor in Non-small Cell Lung Carcinoma. [So] Source: Anticancer Res;38(2):723-736, 2018 02. [Is] ISSN: 1791-7530 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: BACKGROUND: Non-small cell lung carcinomas (NSCLCs), mainly adenocarcinoma (AC) and squamous cell carcinoma (LSCC), account for about 80% of all lung cancer cases. One of the proteins involved in NSCLC progression may be special AT-rich binding protein 1 (SATB1), a potent transcriptional regulator, able to control the expression of whole sets of genes simultaneously. SATB1 has been found to be associated with aggressive phenotype and poor prognosis in numerous malignancies, including breast, colon, ovary and prostate cancer. However, its role in NSCLC is still not fully understood. The aim of this study was to investigate the expression of SATB1 protein and mRNA in NSCLC and non-malignant lung tissue (NMLT) samples, as well as to determine possible relationships of SATB1 expression with both the expression of Ki-67 and the clinicopathological data of the patients. MATERIALS AND METHODS: The study was performed on 277 NSCLC (158 AC, 119 LSCC) and 20 NMLT samples. RESULTS: We observed increased SATB1 immunoreactivity in NSCLC when compared to NMLT, and in LSCC when compared to AC cases. We also noted that an elevated SATB1 immunoreactivity was associated with a poor degree of AC differentiation, whereas in LSCC, an inverse relationship was observed. Our analyses revealed that the expression of SATB1 positively correlated with Ki-67 index in NSCLC and LSCC, but not in AC cases. Finally, we found that high SATB1 expression was associated with a better overall survival of patients with NSCLC. CONCLUSION: SATB1 plays diverse roles in different NSCLC subtypes, and its expression may have a prognostic significance for patients with these tumours. [Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/metabolismo Antígeno Ki-67/metabolismo Neoplasias Pulmonares/metabolismo Proteínas de Ligação à Região de Interação com a Matriz/metabolismo [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Biomarcadores Tumorais/genética Biomarcadores Tumorais/metabolismo Carcinoma Pulmonar de Células não Pequenas/genética Carcinoma Pulmonar de Células não Pequenas/mortalidade Carcinoma Pulmonar de Células não Pequenas/patologia Estudos de Coortes Feminino Fibroblastos/metabolismo Regulação Neoplásica da Expressão Gênica Seres Humanos Estimativa de Kaplan-Meier Neoplasias Pulmonares/genética Neoplasias Pulmonares/mortalidade Neoplasias Pulmonares/patologia Masculino Proteínas de Ligação à Região de Interação com a Matriz/genética Meia-Idade Prognóstico Análise Serial de Tecidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers, Tumor); 0 (Ki-67 Antigen); 0 (Matrix Attachment Region Binding Proteins); 0 (SATB1 protein, human) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180208 [Lr] Data última revisão: 180208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180129 [St] Status: MEDLINE

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[PMID]: 29374747 [Au] Autor: Zhao Y; Xiong GW; Zhang XW; Hang BO [Ad] Endereço: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, P.R. China. [Ti] Título: Is Ki-67 of Diagnostic Value in Distinguishing Between Partial and Complete Hydatidiform Moles? A Systematic Review and Meta-analysis. [So] Source: Anticancer Res;38(2):1105-1110, 2018 02. [Is] ISSN: 1791-7530 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: BACKGROUND/AIM: To demonstrate the value of Ki-67 in distinguishing between partial and complete hydatidiform moles. MATERIALS AND METHODS: We searched electronic databases included Medline, WOK, Cochrane Library and CNKI, through January 24, 2015. Experts were consulted, and references from related articles were examined. The meta-analysis was conducted with RevMan5.3, according to the PRISMA guidelines. Mantel-Haenszel estimates were calculated and pooled under a random effect model, with data expressed as odds ratio (OR) and 95% confidence interval (CI). RESULTS: We analyzed eight trials with a total of 337 participants who underwent uterine curettage and met the inclusion criteria. A significantly higher expression of Ki-67 was observed in complete than in partial hydatidiform moles (OR=3.28; 95%CI=1.80-5.96; p<0.0001). CONCLUSION: The Ki-67 expression was higher in complete than in partial hydatidiform moles. Therefore, Ki-67 may be of diagnostic value in distinguishing between partial and complete hydatidiform moles. However, the present study had only a limited number of samples, so investigation of a greater number of cases is needed to confirm this conclusion. [Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo Mola Hidatiforme/classificação Mola Hidatiforme/diagnóstico Antígeno Ki-67/metabolismo Neoplasias Uterinas/diagnóstico [Mh] Termos MeSH secundário: Feminino Seres Humanos Mola Hidatiforme/metabolismo Gravidez Prognóstico Neoplasias Uterinas/classificação Neoplasias Uterinas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Nm] Nome de substância: 0 (Biomarkers, Tumor); 0 (Ki-67 Antigen) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180207 [Lr] Data última revisão: 180207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180129 [St] Status: MEDLINE

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