Base de dados : MEDLINE
Pesquisa : D12.776.811.690 [Categoria DeCS]
Referências encontradas : 5388 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 539 ir para página                         

  1 / 5388 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29254304
[Au] Autor:Li JK; Wang C; Gong HD; Li HZ
[Ad] Endereço:Department of Neurosurgery, Affiliated HongQi Hospital of Mu Dan Jiang Medical University, Mudanjiang City, China.
[Ti] Título:Coagulation in hindbrain membrane meningioma patients treated with different injections using acute hypervolemic hemodilution.
[So] Source:J Biol Regul Homeost Agents;31(4):991-996, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to analyze the changes in coagulation in meningioma patients treated with different injections using the method of acute hypervolemic hemodilution (AHH). One hundred fifty hindbrain membrane meningioma patients were randomly divided into 5 groups, 30 per group. The first group were injected 40ml/time with Danhong after anesthesia induction; the second group were injected with 40ml~60ml/time Kangai and combined with interventional chemotherapy and embolization procedure; the third group of AHH were injected with polygeline 15ml/kg; the fourth group were injected with hydroxyethyl starch (130/0.4) sodium chloride in doses of 15ml/kg; the control group underwent basic treatment for lowering blood pressure and lowering blood fat. The changes of coagulation index were recorded before and after surgery and before and after the injection of different medications. Compared to the control group, for the first group of AHH, after being treated for 10 days and 30 days, the concentrations of bone specific alkaline phosphatase (BALP), bone Gla protein (BGP) and pro-collagen carboxy-terminal propeptide (PICP) were higher than that of the control group, the levels of endotoxin (ET) and C-reactive protein (CRP) were decreased compared to the control group (p less than 0.05); for the second group of AHH, after being treated for 10 days, the index of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fg) were not significantly changed, but the related level of vascular endothelial growth factor (VEGF) significantly decreased (p less than 0.05). Comparing the coagulation function index after surgery in the third and fourth groups, there were no significant changes in mean arterial pressure (MAP) level, heart rate (HR) value presented a low decrease, central venous pressure (CVP) level increased and the level of interleukin IL-6 showed a steady state after increasing. Analyzing the levels of interleukin IL-8 and tumor necrosis factor-α (TNF-α) after surgery, it was seen that in the third group they increased and in the fourth group they decreased (p less than 0.05). Danhong injection improved the coagulation function and microcirculation of patients, Kangai injection and interventional chemotherapy and embolization restrained the appearance of tumor angiogenesis, AHH operation with polygeline injection and hydroxyethyl starch (130/0.4) sodium chloride kept blood flow in normal parameters.
[Mh] Termos MeSH primário: Coagulação Sanguínea/efeitos dos fármacos
Cardiotônicos/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Hemodiluição/métodos
Neoplasias Meníngeas/tratamento farmacológico
Meningioma/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Fosfatase Alcalina/genética
Fosfatase Alcalina/metabolismo
Pressão Arterial/efeitos dos fármacos
Pressão Arterial/fisiologia
Biomarcadores/metabolismo
Viscosidade Sanguínea/efeitos dos fármacos
Proteína C-Reativa/genética
Proteína C-Reativa/metabolismo
Embolização Terapêutica/métodos
Endotoxinas/metabolismo
Feminino
Fibrinogênio/genética
Fibrinogênio/metabolismo
Expressão Gênica
Frequência Cardíaca/efeitos dos fármacos
Frequência Cardíaca/fisiologia
Seres Humanos
Derivados de Hidroxietil Amido/administração & dosagem
Masculino
Neoplasias Meníngeas/sangue
Neoplasias Meníngeas/patologia
Neoplasias Meníngeas/cirurgia
Meningioma/sangue
Meningioma/patologia
Meningioma/cirurgia
Meia-Idade
Osteocalcina/genética
Osteocalcina/metabolismo
Fragmentos de Peptídeos/genética
Fragmentos de Peptídeos/metabolismo
Substitutos do Plasma/administração & dosagem
Poligelina/administração & dosagem
Pró-Colágeno/genética
Pró-Colágeno/metabolismo
Rombencéfalo/efeitos dos fármacos
Rombencéfalo/metabolismo
Rombencéfalo/patologia
Rombencéfalo/cirurgia
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cardiotonic Agents); 0 (Drugs, Chinese Herbal); 0 (Endotoxins); 0 (Hydroxyethyl Starch Derivatives); 0 (Peptide Fragments); 0 (Plasma Substitutes); 0 (Procollagen); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); 0 (danhong); 0 (procollagen type I carboxy terminal peptide); 104982-03-8 (Osteocalcin); 9001-32-5 (Fibrinogen); 9007-41-4 (C-Reactive Protein); 9015-56-9 (Polygeline); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  2 / 5388 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28448457
[Au] Autor:Schwetz V; Trummer C; Pandis M; Grübler MR; Verheyen N; Gaksch M; Zittermann A; März W; Aberer F; Lang A; Treiber G; Friedl C; Obermayer-Pietsch B; Pieber TR; Tomaschitz A; Pilz S
[Ad] Endereço:Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz 8036, Austria. verena.schwetz@medunigraz.at.
[Ti] Título:Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial.
[So] Source:Nutrients;9(5), 2017 Apr 27.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Bone turnover markers (BTMs) are used to evaluate bone health together with bone mineral density and fracture assessment. Vitamin D supplementation is widely used to prevent and treat musculoskeletal diseases but existing data on vitamin D effects on markers of bone resorption and formation are inconsistent. We therefore examined the effects of vitamin D supplementation on bone-specific alkaline phosphatase (bALP), osteocalcin (OC), C-terminal telopeptide (CTX), and procollagen type 1 N-terminal propeptide (P1NP). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial, a single-center, double-blind, randomized, placebo-controlled trial (RCT) performed at the Medical University of Graz, Austria (2011-2014). Two hundred individuals with arterial hypertension and 25-hydroxyvitamin D (25[OH]D) levels <75 nmol/L were randomized to 2800 IU of vitamin D daily or placebo for eight weeks. One hundred ninety-seven participants (60.2 ± 11.1 years; 47% women) were included in this analysis. Vitamin D had no significant effect on bALP (mean treatment effect (MTE) 0.013, 95% CI -0.029 to 0.056 µg/L; = 0.533), CTX (MTE 0.024, 95% CI -0.163 to 0.210 ng/mL, = 0.802), OC (MTE 0.020, 95% CI -0.062 to 0.103 ng/mL, = 0.626), or P1NP (MTE -0.021, 95% CI -0.099 to 0.057 ng/mL, = 0.597). Analyzing patients with 25(OH)D levels <50 nmol/L separately ( = 74) left results largely unchanged. In hypertensive patients with low 25(OH)D levels, we observed no significant effect of vitamin D supplementation for eight weeks on BTMs.
[Mh] Termos MeSH primário: Remodelação Óssea/efeitos dos fármacos
Vitamina D/administração & dosagem
Vitamina D/farmacologia
[Mh] Termos MeSH secundário: Idoso
Fosfatase Alcalina/genética
Fosfatase Alcalina/metabolismo
Biomarcadores/sangue
Método Duplo-Cego
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Masculino
Meia-Idade
Osteocalcina/genética
Osteocalcina/metabolismo
Fragmentos de Peptídeos/genética
Fragmentos de Peptídeos/metabolismo
Pró-Colágeno/genética
Pró-Colágeno/metabolismo
Vitamina D/análogos & derivados
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Peptide Fragments); 0 (Procollagen); 0 (procollagen Type I N-terminal peptide); 104982-03-8 (Osteocalcin); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  3 / 5388 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29338022
[Au] Autor:Schreiber PW; Bischoff-Ferrari HA; Boggian K; Bonani M; van Delden C; Enriquez N; Fehr T; Garzoni C; Hirsch HH; Hirzel C; Manuel O; Meylan P; Saleh L; Weisser M; Mueller NJ; Swiss Transplant Cohort Study (STCS)
[Ad] Endereço:University Hospital Zurich and University Zurich, Division of Infectious Diseases and Hospital Epidemiology, Zurich, Switzerland.
[Ti] Título:Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation.
[So] Source:PLoS One;13(1):e0191167, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months post-transplant (median 41.9nmol/l; P = 0.272). Six months post-transplant median 1, 25-(OH)2 vitamin D levels increased by >300% (from 9.1 to 36.5ng/l; P<0.001) and median intact parathyroid hormone levels decreased by 68.4% (from 208.7 to 66.0 ng/l; P<0.001). Median ß-Crosslaps (CTx) and total procollagen type 1 amino-terminal propeptide (P1NP) decreased by 65.1% (from 1.32 to 0.46ng/ml; P<0.001) and 60.6% (from 158.2 to 62.3ng/ml; P<0.001), respectively. Kidney recipients with incident fractures had significantly lower levels of 1, 25-(OH)2 vitamin D at time of transplantation and of intact parathyroid hormone 6 months post-transplant. Among 70 liver recipients, 25-OH vitamin D, 1, 25-(OH)2 vitamin D and intact parathyroid hormone levels were not significantly altered between peri-transplant and 6 months post-transplant. Contrary to kidney recipients, median CTx increased by 60.0% (from 0.45 to 0.72 ng/ml; P = 0.002) and P1NP by 49.3% (from 84.0 to 125.4ng/ml; P = 0.001) in the longitudinal course. Assessed biomarkers didn't differ between liver recipients with and without fractures. To conclude, the assessed panel of biomarkers proved highly dynamic after liver as well as kidney transplantation in the early post-transplant period. After kidney transplantation a significant gain in 1, 25-(OH)2 vitamin D combined with a decline in iPTH, CTx and P1NP, whereas after liver transplantation an increase in CTx and P1NP were characteristic.
[Mh] Termos MeSH primário: Osso e Ossos/metabolismo
Transplante de Rim
Transplante de Fígado
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Densidade Óssea
Remodelação Óssea/fisiologia
Colágeno Tipo I/sangue
Feminino
Fraturas Ósseas/etiologia
Taxa de Filtração Glomerular
Seres Humanos
Transplante de Rim/efeitos adversos
Transplante de Fígado/efeitos adversos
Masculino
Meia-Idade
Hormônio Paratireóideo/sangue
Fragmentos de Peptídeos/sangue
Peptídeos/sangue
Fosfatos/sangue
Pró-Colágeno/sangue
Estudos Prospectivos
Vitamina D/análogos & derivados
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Collagen Type I); 0 (PTH protein, human); 0 (Parathyroid Hormone); 0 (Peptide Fragments); 0 (Peptides); 0 (Phosphates); 0 (Procollagen); 0 (collagen type I trimeric cross-linked peptide); 0 (procollagen Type I N-terminal peptide); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D); 66772-14-3 (1,25-dihydroxyvitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191167


  4 / 5388 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29293545
[Au] Autor:Begg GA; Karim R; Oesterlein T; Graham LN; Hogarth AJ; Page SP; Pepper CB; Rhode K; Lip GYH; Holden AV; Plein S; Tayebjee MH
[Ad] Endereço:Department of Cardiology, Leeds General Infirmary, Leeds, United Kingdom.
[Ti] Título:Left atrial voltage, circulating biomarkers of fibrosis, and atrial fibrillation ablation. A prospective cohort study.
[So] Source:PLoS One;13(1):e0189936, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: To test the ability of four circulating biomarkers of fibrosis, and of low left atrial voltage, to predict recurrence of atrial fibrillation after catheter ablation. BACKGROUND: Circulating biomarkers potentially may be used to improve patient selection for atrial fibrillation ablation. Low voltage areas in the left atrium predict arrhythmia recurrence when mapped in sinus rhythm. This study tested type III procollagen N terminal peptide (PIIINP), galectin-3 (gal-3), fibroblast growth factor 23 (FGF-23), and type I collagen C terminal telopeptide (ICTP), and whether low voltage areas in the left atrium predicted atrial fibrillation recurrence, irrespective of the rhythm during mapping. METHODS: 92 atrial fibrillation ablation patients were studied. Biomarker levels in peripheral and intra-cardiac blood were measured with enzyme-linked immunosorbent assay. Low voltage (<0.5mV) was expressed as a proportion of the mapped left atrial surface area. Follow-up was one year. The primary endpoint was recurrence of arrhythmia. The secondary endpoint was a composite of recurrence despite two procedures, or after one procedure if no second procedure was undertaken. RESULTS: The biomarkers were not predictive of either endpoint. After multivariate Cox regression analysis, high proportion of low voltage area in the left atrium was found to predict the primary endpoint in sinus rhythm mapping (hazard ratio 4.323, 95% confidence interval 1.337-13.982, p = 0.014) and atrial fibrillation mapping (hazard ratio 5.195, 95% confidence interval 1.032-26.141, p = 0.046). This effect was also apparent for the secondary endpoint. CONCLUSION: The studied biomarkers do not predict arrhythmia recurrence after catheter ablation. Left atrial voltage is an independent predictor of recurrence, whether the left atrium is mapped in atrial fibrillation or sinus rhythm.
[Mh] Termos MeSH primário: Fibrilação Atrial/cirurgia
Biomarcadores/sangue
Ablação por Cateter/métodos
Átrios do Coração/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Fibrilação Atrial/fisiopatologia
Colágeno Tipo I/sangue
Feminino
Fatores de Crescimento de Fibroblastos/sangue
Fibrose
Galectina 3/sangue
Seres Humanos
Masculino
Meia-Idade
Fragmentos de Peptídeos/sangue
Peptídeos/sangue
Pró-Colágeno/sangue
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Collagen Type I); 0 (Galectin 3); 0 (Peptide Fragments); 0 (Peptides); 0 (Procollagen); 0 (collagen type I trimeric cross-linked peptide); 0 (fibroblast growth factor 23); 0 (galectin-3, human); 0 (procollagen Type III-N-terminal peptide); 62031-54-3 (Fibroblast Growth Factors)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189936


  5 / 5388 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29046326
[Au] Autor:Eastell R; Pigott T; Gossiel F; Naylor KE; Walsh JS; Peel NFA
[Ad] Endereço:Academic Unit of Bone MetabolismUniversity of Sheffield, Sheffield, UK r.eastell@sheffield.ac.uk.
[Ti] Título:DIAGNOSIS OF ENDOCRINE DISEASE: Bone turnover markers: are they clinically useful?
[So] Source:Eur J Endocrinol;178(1):R19-R31, 2018 Jan.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bone turnover markers (BTMs) are useful in clinical practice as they are inexpensive, and they have proven useful for treatment monitoring and identification of poor adherence. BTMs cannot be used in individual patients for identifying accelerated bone loss or an increase in fracture risk or in deciding on the optimal therapy. They are useful for monitoring both anti-resorptive and anabolic treatment. Response can be defined as a result that exceeds an absolute target, or by a change greater than the least significant change; if such a response is not present, then poor compliance or secondary osteoporosis are likely causes. A baseline BTM measurement is not always made; in that case, a value of BTM on anti-resorptive treatment that is low or low normal or above the reference interval for anabolic therapy may be taken to indicate a satisfactory response. We provide an approach to using these bone turnover markers in clinical practice by describing algorithms for anti-resorptive and anabolic therapy and describing the changes we observe in the clinical practice setting.
[Mh] Termos MeSH primário: Remodelação Óssea/fisiologia
Doenças do Sistema Endócrino/diagnóstico
Doenças do Sistema Endócrino/metabolismo
[Mh] Termos MeSH secundário: Biomarcadores/metabolismo
Densidade Óssea/fisiologia
Reabsorção Óssea/diagnóstico
Reabsorção Óssea/metabolismo
Seres Humanos
Osteocalcina/metabolismo
Fragmentos de Peptídeos/metabolismo
Pró-Colágeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Peptide Fragments); 0 (Procollagen); 0 (procollagen Type I N-terminal peptide); 104982-03-8 (Osteocalcin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0585


  6 / 5388 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28853593
[Au] Autor:Rajeev P; Movseysan A; Baharani A
[Ad] Endereço:Department of Endocrine Surgery, National University Hospital , Singapore.
[Ti] Título:Changes in bone turnover markers in primary hyperparathyroidism and response to surgery.
[So] Source:Ann R Coll Surg Engl;99(7):559-562, 2017 Sep.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Introduction Involvement of the bone is common in primary hyperparathyroidism. The aim of the study was to assess bone turnover markers in response to surgery for primary hyperparathyroidism. Methods This was a retrospective study of patients diagnosed and treated for parathyroid disease between 2005 and 2012. Interventions studied were surgery and medical treatment. The main outcome measures studied were serum levels of calcium, intact parathyroid hormone (iPTH), bone-specific alkaline phosphatase, N-terminal cross-linking propeptide of type 1 procollagen (P1NP) and C-terminal cross-linking telopeptides of type I collagen (CTX), both pre- and postoperatively at 6 months and 1 year; bone mineral density (at the spine and hip assessed by dual-energy x-ray absorptiometry after 1 year of treatment. Results A total of 122 (110 female, 12 male) patients (age range 25-91 years) underwent treatment for parathyroid disease during the study period; 30 patients were treated conservatively and 92 proceeded to surgery following localisation studies. Following surgical intervention, P1NP dropped significantly from a mean of 64.68 ng/ml (standard deviation, SD ± 68.07 ng/ml) preoperatively to 26.37 ng/ml (SD ± 20.94 ng/ml) and CTX from 0.69 pg/ml (SD ± 0.44 pg/ml) to 0.15 pg/ml (SD ± 0.16 pg/ml) at 6-12 months (P < 0.0001). This change was reflected in improvement in bone mineral density (T scores) of the hip and spine by 43% (P < 0.03) and 38% (P < 0.01), respectively, following surgery. In patients treated conservatively (n = 30), there was no improvement either in the bone turnover markers or bone densitometry scans. Conclusions Surgery improves bone density in patients with parathyroid disease. Improvement in serum bone turnover markers is seen following parathyroidectomy. The association with bone density needs further evaluation in larger studies.
[Mh] Termos MeSH primário: Hiperparatireoidismo Primário/cirurgia
Paratireoidectomia/efeitos adversos
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adulto
Idoso
Idoso de 80 Anos ou mais
Fosfatase Alcalina/sangue
Biomarcadores/sangue
Densidade Óssea
Cálcio/sangue
Colágeno Tipo I/sangue
Feminino
Seres Humanos
Hiperparatireoidismo Primário/sangue
Masculino
Meia-Idade
Hormônio Paratireóideo/sangue
Fragmentos de Peptídeos/sangue
Peptídeos/sangue
Pró-Colágeno/sangue
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Collagen Type I); 0 (Parathyroid Hormone); 0 (Peptide Fragments); 0 (Peptides); 0 (Procollagen); 0 (collagen type I trimeric cross-linked peptide); 0 (procollagen Type I N-terminal peptide); EC 3.1.3.1 (Alkaline Phosphatase); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1308/rcsann.2017.0092


  7 / 5388 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28767656
[Au] Autor:Lipczynska M; Szymanski P; Kumor M; Klisiewicz A; Hoffman P
[Ad] Endereço:Adult Congenital Heart Disease Department, Institute of Cardiology, Warsaw, Poland.
[Ti] Título:Collagen turnover biomarkers and systemic right ventricle remodeling in adults with previous atrial switch procedure for transposition of the great arteries.
[So] Source:PLoS One;12(8):e0180629, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Myocardial fibrosis is a potential pathophysiological mechanism leading to systemic right ventricular (SRV) deterioration. We hypothesize that circulating levels of collagen deposition markers are elevated in patients with SRV remodeling and this elevation may have a predictive value. METHODS: We prospectively evaluated 56 patients with D-TGA after the atrial switch procedure (mean age 25.6 ± 4.8, range 18-37 years; 67% males). Serum levels of procollagen type III amino-terminal propeptide (PIIINP), collagen type I carboxy-terminal telopeptide (CITP), procollagen type I N-terminal propeptide (PINP), matrix metalloproteinase (MMP 1, MMP 9) and a tissue inhibitor of matrix metalloproteinase (TIMP 1) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) were measured and compared with healthy controls. The relationship between these serum markers, echocardiographic and cardiac magnetic resonance parameters and the outcome at a follow-up of 61 months (range, 24-85 months) was determined. RESULTS: Compared with the healthy control group, the study group had significantly higher levels of TIMP1, PIIINP, CITP, PINP and NT-pro-BNP (p<0.05, each). The levels of PIIINP and CITP were significantly higher among patients with an SRV mass index above the mean value. The level of PIIINP was significantly higher among patients with an SRV EDV index above the mean value. CITP was significantly elevated in SRV late gadolinium enhanced (LGE) positive patients, compared to patients without SRV LGE. MMP9 and TIMP1 predicted an adverse clinical outcome on univariate Cox proportional hazard survival analysis in addition to well proven predictors of outcome (SRV EF and NYHA). CONCLUSIONS: We demonstrated a pattern of altered collagen turnover adversely related with the indices of SRV remodeling and an adverse clinical outcome in patients with SRV.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Transposição dos Grandes Vasos/sangue
Remodelação Ventricular/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Transposição das grandes artérias
Estudos de Casos e Controles
Estudos Transversais
Feminino
Seguimentos
Seres Humanos
Masculino
Metaloproteinase 9 da Matriz/sangue
Peptídeo Natriurético Encefálico/sangue
Fragmentos de Peptídeos/sangue
Pró-Colágeno/sangue
Modelos de Riscos Proporcionais
Estudos Prospectivos
Inibidor Tecidual de Metaloproteinase-1/sangue
Transposição dos Grandes Vasos/patologia
Transposição dos Grandes Vasos/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Peptide Fragments); 0 (Procollagen); 0 (TIMP1 protein, human); 0 (Tissue Inhibitor of Metalloproteinase-1); 0 (pro-brain natriuretic peptide (1-76)); 0 (procollagen Type I N-terminal peptide); 0 (procollagen Type III-N-terminal peptide); 114471-18-0 (Natriuretic Peptide, Brain); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180629


  8 / 5388 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28581213
[Au] Autor:Arzpayma P; Callander J; Macfarlane A
[Ad] Endereço:Betsi Cadwaladr University Health Board, Ysbyty Gwynedd, Bangor, Gwynedd, North Wales, LL57 2PW, U.K.
[Ti] Título:Comparison of enhanced liver fibrosis test with procollagen-3 N-terminal peptide (P3NP) as a marker for liver fibrosis.
[So] Source:Br J Dermatol;176(6):1439-1440, 2017 06.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Testes de Função Hepática
Pró-Colágeno
[Mh] Termos MeSH secundário: Biomarcadores
Seres Humanos
Fígado
Cirrose Hepática
Fragmentos de Peptídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Biomarkers); 0 (Peptide Fragments); 0 (Procollagen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15590


  9 / 5388 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28555718
[Au] Autor:Rawson KS; Dixon D; Civitelli R; Peterson TR; Mulsant BH; Reynolds CF; Lenze EJ
[Ad] Endereço:Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri.
[Ti] Título:Bone Turnover with Venlafaxine Treatment in Older Adults with Depression.
[So] Source:J Am Geriatr Soc;65(9):2057-2063, 2017 Sep.
[Is] ISSN:1532-5415
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Epidemiologic data suggest older adults receiving serotonergic antidepressants may have accelerated bone loss. We examined bone turnover marker changes and patient-level variables associated with these changes in older adults receiving protocolized antidepressant treatment. DESIGN: Open-label, protocolized treatment study. SETTING: Medical centers in Pittsburgh, St Louis, and Toronto. PARTICIPANTS: Older adults with major depression (N = 168). MEASUREMENTS: Serum levels of the bone resorption marker C-terminal cross-linking telopeptide of type 1 collagen (CTX) and the bone formation marker procollagen type 1 N propeptide (P1NP) were assayed before and after 12 weeks of treatment with venlafaxine. Whether CTX and P1NP changes were associated with depression remission and duration of depression and genetic polymorphisms in the serotonin transporter (5HTTLPR) and 1B receptor (HTR1B) were also examined. RESULTS: CTX increased and P1NP decreased during venlafaxine treatment, a profile consistent with accelerated bone loss. Two individual-level clinical variables were correlated with bone turnover; participants whose depression did not go into remission had higher CTX levels, and those with chronic depression had lower P1NP levels. HTR1B genotype predicted P1NP change, whereas 5HTTLPR genotype was unrelated to either biomarker. CONCLUSION: Bone turnover markers change with antidepressant treatment in a pattern that suggests accelerated bone loss, although the clinical significance of these changes is unclear. These data are preliminary and argue for a larger, controlled study to confirm whether antidepressants are harmful to bone metabolism and whether certain individuals might be at increased risk.
[Mh] Termos MeSH primário: Remodelação Óssea/efeitos dos fármacos
Transtorno Depressivo Maior/tratamento farmacológico
Inibidores da Recaptação de Serotonina e Norepinefrina/uso terapêutico
Cloridrato de Venlafaxina/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/sangue
Colágeno Tipo I/sangue
Feminino
Seres Humanos
Masculino
Pró-Colágeno/sangue
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Collagen Type I); 0 (Procollagen); 0 (Serotonin and Noradrenaline Reuptake Inhibitors); 7D7RX5A8MO (Venlafaxine Hydrochloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1111/jgs.14936


  10 / 5388 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28515098
[Au] Autor:Duprez DA; Gross MD; Sanchez OA; Kizer JR; Ix JH; Lima J; Tracy RP; Jacobs DR
[Ad] Endereço:Cardiovascular Division, School of Medicine, dupre007@umn.edu.
[Ti] Título:Collagen Turnover Markers in Relation to Future Cardiovascular and Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
[So] Source:Clin Chem;63(7):1237-1247, 2017 Jul.
[Is] ISSN:1530-8561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sustained remodeling of extracellular matrix can compromise organs and tissues. Procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) reflect collagen synthesis and degradation. We studied their predictive value for future death and disease. METHODS: A total of 3068 men and women in the Multi-Ethnic Study of Atherosclerosis who were free of cardiovascular disease (CVD) and in generally good health had a baseline blood sample taken for ICTP and PIIINP. Median follow-up was 13.0 years. Among 4 primary outcomes, CVD events (n = 697) were adjudicated, death (n = 571) was by death certificate, and chronic inflammatory-related severe hospitalization and death (ChrIRD, n = 726) and total cancer (n = 327) were classified using International Classification of Diseases codes. We used Poisson regression to study baseline ICTP and PIIINP relative to these outcomes. RESULTS: Mean (SD) PIIINP was 5.47 (1.95) µg/L and ICTP was 3.37 (1.70) µg/L. PIIINP and ICTP were highly correlated with each other and with estimated glomerular filtration rate (eGFR). Adjustment for age and eGFR attenuated relative risks, remaining 20%-30% per SD of both PIIINP and ICTP in prediction for total death and ChrIRD, and of PIIINP for cancer, with little additional attenuation by adjusting for risk factors and inflammatory biomarkers. CVD outcome was generally unrelated to PIIINP but became marginally inversely related to ICTP in the most adjusted model. CONCLUSIONS: The collagen biomarkers PIIINP and ICTP, in part through pathophysiologically parallel associations with renal function, predicted ChrIRD and total death. Moreover, PIIINP predicted future cancer. These collagen markers may help differentiate healthy from unhealthy aging.
[Mh] Termos MeSH primário: Aterosclerose/diagnóstico
Aterosclerose/etnologia
Biomarcadores/sangue
Doenças Cardiovasculares/diagnóstico
Colágeno/sangue
Valor Preditivo dos Testes
[Mh] Termos MeSH secundário: Aterosclerose/sangue
Doenças Cardiovasculares/sangue
Colágeno/metabolismo
Colágeno Tipo I/sangue
Grupos Étnicos/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Meia-Idade
Neoplasias/sangue
Neoplasias/diagnóstico
Fragmentos de Peptídeos/sangue
Peptídeos/sangue
Pró-Colágeno/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Collagen Type I); 0 (Peptide Fragments); 0 (Peptides); 0 (Procollagen); 0 (collagen type I trimeric cross-linked peptide); 0 (procollagen Type III-N-terminal peptide); 9007-34-5 (Collagen)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1373/clinchem.2016.270520



página 1 de 539 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde