Base de dados : MEDLINE
Pesquisa : D12.776.827 [Categoria DeCS]
Referências encontradas : 14731 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1474 ir para página                         

  1 / 14731 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28751111
[Au] Autor:Poudel S; Kim Y; Gwak JS; Jeong S; Lee Y
[Ad] Endereço:Department of Bio and Fermentation Convergence Technology, BK21 PLUS Project, Kookmin University, Seoul 02707, South Korea.
[Ti] Título:Gustatory receptor 22e is essential for sensing chloroquine and strychnine in Drosophila melanogaster.
[So] Source:Insect Biochem Mol Biol;88:30-36, 2017 Sep.
[Is] ISSN:1879-0240
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chloroquine, an amino quinolone derivative commonly used as an anti-malarial drug, is known to impart an unpleasant taste. Little research has been done to study chloroquine taste in insects, therefore, we examined both the deterrant properties and mechanisms underlying chloroquine perception in fruit flies. We identified the antifeedant effect of chloroquine by screening 21 gustatory receptor (Grs) mutants through behavioral feeding assays and electrophysiology experiments. We discovered that two molecular sensors, GR22e and GR33a, act as chloroquine receptors, and found that chloroquine-mediated activation of GRNs occurs through S-type sensilla. At the same time, we successfully recapitulated the chloroquine receptor by expressing GR22e in ectopic gustatory receptor neurons. We also found that GR22e forms a part of the strychnine receptor. We suggest that the Drosophila strychnine receptor might have a very complex structure since five different GRs are required for strychnine-induced action potentials.
[Mh] Termos MeSH primário: Proteínas de Drosophila/metabolismo
Drosophila melanogaster/metabolismo
Receptores de Superfície Celular/metabolismo
Receptores de Droga/isolamento & purificação
Receptores da Glicina/isolamento & purificação
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Animais
Cloroquina/metabolismo
Drosophila melanogaster/química
Drosophila melanogaster/efeitos dos fármacos
Feminino
Masculino
Neurônios Receptores Olfatórios/efeitos dos fármacos
Neurônios Receptores Olfatórios/metabolismo
Receptores de Droga/metabolismo
Receptores da Glicina/metabolismo
Sensilas/metabolismo
Estricnina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Receptors, Cell Surface); 0 (Receptors, Drug); 0 (Receptors, Glycine); 0 (chloroquine receptor); 0 (gustatory receptor, Drosophila); 0 (strychnine receptor); 886U3H6UFF (Chloroquine); H9Y79VD43J (Strychnine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE


  2 / 14731 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28566500
[Au] Autor:Li J; Hatano R; Xu S; Wan L; Yang L; Weinstein AM; Palmer L; Wang T
[Ad] Endereço:Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut.
[Ti] Título:Gender difference in kidney electrolyte transport. I. Role of AT receptor in thiazide-sensitive Na -Cl cotransporter activity and expression in male and female mice.
[So] Source:Am J Physiol Renal Physiol;313(2):F505-F513, 2017 Aug 01.
[Is] ISSN:1522-1466
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We studied gender differences in Na -Cl cotransporter (NCC) activity and expression in wild-type (WT) and AT receptor knockout (KO) mice. In renal clearance experiments, urine volume (UV), glomerular filtration rate, absolute Na (E ) and K (E ), and fractional Na (FE ) and K excretion were measured and compared at peak changes after bolus intravenous injection of hydrochlorothiazide (HCTZ; 30 mg/kg). In WT, females responded more strongly than males to HCTZ, with larger fractional increases of UV (7.8- vs. 3.4-fold), E (11.7- vs. 5.7-fold), FE (7.9- vs. 4.9-fold), and E (2.8- vs. 1.4-fold). In contrast, there were no gender differences in the responses to the diuretic in KO mice; HCTZ produced greater effects on male KO than on WT but similar effects on females. In WT, total (tNCC) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males ( < 0.05), consistent with the larger response to HCTZ. In KO mice, tNCC and pNCC increased significantly in males to levels not different from those in females. There were no gender differences in the expression of the Na /H exchanger (NHE3) in WT; NHE3 protein decreased to similar extents in male and female KO animals, suggesting AT -mediated NHE3 expression in proximal tubules. The resulting increase in delivery of NaCl to the distal nephron may underlie increased NCC expression and activity in mice lacking the AT receptor.
[Mh] Termos MeSH primário: Angiotensina II/metabolismo
Receptor Tipo 1 de Angiotensina/metabolismo
Caracteres Sexuais
Trocadores de Sódio-Hidrogênio/metabolismo
[Mh] Termos MeSH secundário: Animais
Diurese
Feminino
Hidroclorotiazida
Rim/metabolismo
Masculino
Camundongos Knockout
Natriurese
Fenótipo
Proteínas Serina-Treonina Quinases/metabolismo
Receptor Tipo 1 de Angiotensina/genética
Receptores de Droga/metabolismo
Simportadores de Cloreto de Sódio/metabolismo
Trocador 3 de Sódio-Hidrogênio
Membro 3 da Família 12 de Carreador de Soluto/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptor, Angiotensin, Type 1); 0 (Receptors, Drug); 0 (Slc12a3 protein, mouse); 0 (Slc9a3 protein, mouse); 0 (Sodium Chloride Symporters); 0 (Sodium-Hydrogen Exchanger 3); 0 (Sodium-Hydrogen Exchangers); 0 (Solute Carrier Family 12, Member 3); 0 (thiazide receptor); 0J48LPH2TH (Hydrochlorothiazide); 11128-99-7 (Angiotensin II); EC 2.7.1.- (Prkwnk4 protein, mouse); EC 2.7.1.- (Stk39 protein, mouse); EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1152/ajprenal.00087.2017


  3 / 14731 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28495080
[Au] Autor:Ma W; Yang L; Lv Y; Fu J; Zhang Y; He L
[Ad] Endereço:School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
[Ti] Título:Determine equilibrium dissociation constant of drug-membrane receptor affinity using the cell membrane chromatography relative standard method.
[So] Source:J Chromatogr A;1503:12-20, 2017 Jun 23.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The equilibrium dissociation constant (K ) of drug-membrane receptor affinity is the basic parameter that reflects the strength of interaction. The cell membrane chromatography (CMC) method is an effective technique to study the characteristics of drug-membrane receptor affinity. In this study, the K value of CMC relative standard method for the determination of drug-membrane receptor affinity was established to analyze the relative K values of drugs binding to the membrane receptors (Epidermal growth factor receptor and angiotensin II receptor). The K values obtained by the CMC relative standard method had a strong correlation with those obtained by the frontal analysis method. Additionally, the K values obtained by CMC relative standard method correlated with pharmacological activity of the drug being evaluated. The CMC relative standard method is a convenient and effective method to evaluate drug-membrane receptor affinity.
[Mh] Termos MeSH primário: Membrana Celular/química
Técnicas de Química Analítica/métodos
Cromatografia
Receptores de Droga/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Drug)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE


  4 / 14731 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28380234
[Au] Autor:Marakovic N; Sinko G
[Ti] Título:The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry.
[So] Source:Acta Chim Slov;64(1):15-39, 2017 Mac.
[Is] ISSN:1318-0207
[Cp] País de publicação:Slovenia
[La] Idioma:eng
[Ab] Resumo:Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-called building blocks, the problem of successfully identifying leads remains. The introduction of a dynamic combinatorial chemistry method served as a step forward due to the involvement of biological macromolecular targets (receptors) in the synthesis of high affinity products. The major breakthrough was a synthetic method in which building blocks are irreversibly combined due to the presence of a receptor. Here we present various receptor-based combinatorial chemistry approaches. Huisgen's cycloaddition (1,3-dipolar cycloaddition of azides and alkynes) forms stabile 1,2,3-triazoles with very high receptor affinity that can reach femtomolar levels, as the case with acetylcholinesterase inhibitors shows. Huisgen's cycloaddition can be applied to various receptors including acetylcholinesterase, acetylcholine binding protein, carbonic anhydrase-II, serine/threonine-protein kinase and minor groove of DNA.
[Mh] Termos MeSH primário: Técnicas de Química Combinatória
Desenho de Drogas
Receptores de Droga/química
[Mh] Termos MeSH secundário: Química Click
Reação de Cicloadição
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Receptors, Drug)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


  5 / 14731 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28074396
[Au] Autor:Koch G; Jusko WJ; Schropp J
[Ad] Endereço:Pediatric Pharmacology and Pharmacometrics, University of Basel, Children's Hospital (UKBB), Spitalstrasse 33, 4056, Basel, Switzerland. gilbert.koch@ukbb.ch.
[Ti] Título:Target mediated drug disposition with drug-drug interaction, Part II: competitive and uncompetitive cases.
[So] Source:J Pharmacokinet Pharmacodyn;44(1):27-42, 2017 Feb.
[Is] ISSN:1573-8744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present competitive and uncompetitive drug-drug interaction (DDI) with target mediated drug disposition (TMDD) equations and investigate their pharmacokinetic DDI properties. For application of TMDD models, quasi-equilibrium (QE) or quasi-steady state (QSS) approximations are necessary to reduce the number of parameters. To realize those approximations of DDI TMDD models, we derive an ordinary differential equation (ODE) representation formulated in free concentration and free receptor variables. This ODE formulation can be straightforward implemented in typical PKPD software without solving any non-linear equation system arising from the QE or QSS approximation of the rapid binding assumptions. This manuscript is the second in a series to introduce and investigate DDI TMDD models and to apply the QE or QSS approximation.
[Mh] Termos MeSH primário: Interações Medicamentosas
Modelos Biológicos
Preparações Farmacêuticas
Farmacocinética
[Mh] Termos MeSH secundário: Ligação Competitiva
Química Farmacêutica
Relação Dose-Resposta a Droga
Seres Humanos
Preparações Farmacêuticas/administração & dosagem
Preparações Farmacêuticas/química
Ligação Proteica
Receptores de Droga/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Receptors, Drug)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1007/s10928-016-9502-0


  6 / 14731 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28074395
[Au] Autor:Koch G; Jusko WJ; Schropp J
[Ad] Endereço:Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Spitalstrasse 33, 4056, Basel, Switzerland. gilbert.koch@ukbb.ch.
[Ti] Título:Target-mediated drug disposition with drug-drug interaction, Part I: single drug case in alternative formulations.
[So] Source:J Pharmacokinet Pharmacodyn;44(1):17-26, 2017 Feb.
[Is] ISSN:1573-8744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Target-mediated drug disposition (TMDD) describes drug binding with high affinity to a target such as a receptor. In application TMDD models are often over-parameterized and quasi-equilibrium (QE) or quasi-steady state (QSS) approximations are essential to reduce the number of parameters. However, implementation of such approximations becomes difficult for TMDD models with drug-drug interaction (DDI) mechanisms. Hence, alternative but equivalent formulations are necessary for QE or QSS approximations. To introduce and develop such formulations, the single drug case is reanalyzed. This work opens the route for straightforward implementation of QE or QSS approximations of DDI TMDD models. The manuscript is the first part to introduce DDI TMDD models with QE or QSS approximations.
[Mh] Termos MeSH primário: Interações Medicamentosas
Modelos Biológicos
Preparações Farmacêuticas
Farmacocinética
[Mh] Termos MeSH secundário: Ligação Competitiva
Química Farmacêutica
Seres Humanos
Infusões Intravenosas
Preparações Farmacêuticas/administração & dosagem
Preparações Farmacêuticas/química
Ligação Proteica
Receptores de Droga/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Receptors, Drug)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1007/s10928-016-9501-1


  7 / 14731 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27815594
[Au] Autor:Murthy M; Kurz T; O'Shaughnessy KM
[Ad] Endereço:Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, CB2 2QQ, UK.
[Ti] Título:WNK signalling pathways in blood pressure regulation.
[So] Source:Cell Mol Life Sci;74(7):1261-1280, 2017 Apr.
[Is] ISSN:1420-9071
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Hypertension (high blood pressure) is a major public health problem affecting more than a billion people worldwide with complications, including stroke, heart failure and kidney failure. The regulation of blood pressure is multifactorial reflecting genetic susceptibility, in utero environment and external factors such as obesity and salt intake. In keeping with Arthur Guyton's hypothesis, the kidney plays a key role in blood pressure control and data from clinical studies; physiology and genetics have shown that hypertension is driven a failure of the kidney to excrete excess salt at normal levels of blood pressure. There is a number of rare Mendelian blood pressure syndromes, which have shed light on the molecular mechanisms involved in dysregulated ion transport in the distal kidney. One in particular is Familial hyperkalemic hypertension (FHHt), an autosomal dominant monogenic form of hypertension characterised by high blood pressure, hyperkalemia, hyperchloremic metabolic acidosis, and hypercalciuria. The clinical signs of FHHt are treated by low doses of thiazide diuretic, and it mirrors Gitelman syndrome which features the inverse phenotype of hypotension, hypokalemic metabolic alkalosis, and hypocalciuria. Gitelman syndrome is caused by loss of function mutations in the thiazide-sensitive Na/Cl cotransporter (NCC); however, FHHt patients do not have mutations in the SCL12A3 locus encoding NCC. Instead, mutations have been identified in genes that have revealed a key signalling pathway that regulates NCC and several other key transporters and ion channels in the kidney that are critical for BP regulation. This is the WNK kinase signalling pathway that is the subject of this review.
[Mh] Termos MeSH primário: Pressão Sanguínea/fisiologia
Hipertensão/patologia
Receptores de Droga/metabolismo
Transdução de Sinais
Simportadores de Cloreto de Sódio/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas Culina/metabolismo
Seres Humanos
Hipertensão/genética
Hipertensão/metabolismo
Neovascularização Fisiológica
Proteínas Serina-Treonina Quinases/metabolismo
Pseudo-Hipoaldosteronismo/genética
Pseudo-Hipoaldosteronismo/patologia
Receptores de Droga/química
Receptores de Droga/genética
Simportadores de Cloreto de Sódio/química
Simportadores de Cloreto de Sódio/genética
Simportadores de Cloreto de Sódio-Potássio/genética
Simportadores de Cloreto de Sódio-Potássio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cullin Proteins); 0 (Receptors, Drug); 0 (Sodium Chloride Symporters); 0 (Sodium-Potassium-Chloride Symporters); 0 (thiazide receptor); EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE
[do] DOI:10.1007/s00018-016-2402-z


  8 / 14731 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27857139
[Au] Autor:Crunkhorn S
[Ti] Título:Drug design: Cannabinoid receptor structure revealed.
[So] Source:Nat Rev Drug Discov;15(12):822, 2016 12.
[Is] ISSN:1474-1784
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Desenho de Drogas
Receptores de Canabinoides
[Mh] Termos MeSH secundário: Canabinoides/química
Ligantes
Estrutura Molecular
Receptores de Droga/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Cannabinoids); 0 (Ligands); 0 (Receptors, Cannabinoid); 0 (Receptors, Drug)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1038/nrd.2016.242


  9 / 14731 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27638639
[Au] Autor:Koch G; Schropp J; Jusko WJ
[Ad] Endereço:Pediatric Pharmacology and Pharmacometrics, University of Basel, Children's Hospital (UKBB), Spitalstrasse 33, 4056, Basel, Switzerland. gilbert.koch@ukbb.ch.
[Ti] Título:Assessment of non-linear combination effect terms for drug-drug interactions.
[So] Source:J Pharmacokinet Pharmacodyn;43(5):461-79, 2016 10.
[Is] ISSN:1573-8744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Drugs interact with their targets in different ways. A diversity of modeling approaches exists to describe the combination effects of two drugs. We investigate several combination effect terms (CET) regarding their underlying mechanism based on drug-receptor binding kinetics, empirical and statistical summation principles and indirect response models. A list with properties is provided and the interrelationship of the CETs is analyzed. A method is presented to calculate the optimal drug concentration pair to produce the half-maximal combination effect. This work provides a comprehensive overview of typically applied CETs and should shed light into the question as to which CET is appropriate for application in pharmacokinetic/pharmacodynamic models to describe a specific drug-drug interaction mechanism.
[Mh] Termos MeSH primário: Interações Medicamentosas
Modelos Biológicos
Farmacocinética
[Mh] Termos MeSH secundário: Simulação por Computador
Relação Dose-Resposta a Droga
Quimioterapia Combinada
Seres Humanos
Cinética
Dinâmica não Linear
Preparações Farmacêuticas/administração & dosagem
Preparações Farmacêuticas/metabolismo
Ligação Proteica
Receptores de Droga/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Receptors, Drug)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE
[do] DOI:10.1007/s10928-016-9490-0


  10 / 14731 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27612462
[Au] Autor:Krzyzanski W; Harrold JM; Wu LS; Perez-Ruixo JJ
[Ad] Endereço:Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, USA.
[Ti] Título:A cell-level model of pharmacodynamics-mediated drug disposition.
[So] Source:J Pharmacokinet Pharmacodyn;43(5):513-27, 2016 10.
[Is] ISSN:1573-8744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We aimed to develop a cell-level pharmacodynamics-mediated drug disposition (PDMDD) model to analyze in vivo systems where the PD response to a drug has an appreciable effect on the pharmacokinetics (PK). An existing cellular level model of PD stimulation was combined with the standard target-mediated drug disposition (TMDD) model and the resulting model structure was parametrically identifiable from typical in vivo PK and PD data. The PD model of the cell population was controlled by the production rate k in and elimination rate k out which could be stimulated or inhibited by the number of bound receptors on a single cell. Simulations were performed to assess the impact of single and repeated dosing on the total drug clearance. The clinical utility of the cell-level PDMDD model was demonstrated by fitting published data on the stimulatory effects of filgrastim on absolute neutrophil counts in healthy subjects. We postulated repeated dosing as a means of detecting and quantifying PDMDD as a single dose might not be sufficient to elicit the cellular response capable of altering the receptor pool to visibly affect drug disposition. In the absence of any PD effect, the model reduces down to the standard TMDD model. The applications of this model can be readily extended to include chemotherapy-induced cytopenias affecting clearance of endogenous hematopoietic growth factors, different monoclonal antibodies and immunogenicity effects on PK.
[Mh] Termos MeSH primário: Filgrastim/farmacocinética
Fármacos Hematológicos/farmacocinética
Modelos Biológicos
Neutrófilos/efeitos dos fármacos
Receptores de Droga/metabolismo
[Mh] Termos MeSH secundário: Transporte Biológico
Simulação por Computador
Relação Dose-Resposta a Droga
Filgrastim/administração & dosagem
Fármacos Hematológicos/administração & dosagem
Fármacos Hematológicos/sangue
Seres Humanos
Taxa de Depuração Metabólica
Neutrófilos/citologia
Neutrófilos/metabolismo
Dinâmica não Linear
Ligação Proteica
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hematologic Agents); 0 (Receptors, Drug); PVI5M0M1GW (Filgrastim)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE
[do] DOI:10.1007/s10928-016-9491-z



página 1 de 1474 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde