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[PMID]:28455402
[Au] Autor:Pinon V; Yao X; Dong A; Shen WH
[Ad] Endereço:Université de Strasbourg, Centre National de la Recherche Scientifique UPR2357, F-67000 Strasbourg, France (V.P., W.-H.S.).
[Ti] Título:SDG2-Mediated H3K4me3 Is Crucial for Chromatin Condensation and Mitotic Division during Male Gametogenesis in Arabidopsis.
[So] Source:Plant Physiol;174(2):1205-1215, 2017 Jun.
[Is] ISSN:1532-2548
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epigenetic reprogramming occurring during reproduction is crucial for both animal and plant development. Histone H3 Lys 4 trimethylation (H3K4me3) is an evolutionarily conserved epigenetic mark of transcriptional active euchromatin. While much has been learned in somatic cells, H3K4me3 deposition and function in gametophyte is poorly studied. Here, we demonstrate that SET DOMAIN GROUP2 (SDG2)-mediated H3K4me3 deposition participates in epigenetic reprogramming during Arabidopsis male gametogenesis. We show that loss of SDG2 barely affects meiosis and cell fate establishment of haploid cells. However, we found that SDG2 is critical for postmeiotic microspore development. Mitotic cell division progression is partly impaired in the loss-of-function mutant, particularly at the second mitosis setting up the two sperm cells. We demonstrate that SDG2 is involved in promoting chromatin decondensation in the pollen vegetative nucleus, likely through its role in H3K4me3 deposition, which prevents ectopic heterochromatic H3K9me2 speckle formation. Moreover, we found that derepression of the LTR retrotransposon is compromised in the vegetative cell of the mutant pollen. Consistent with chromatin condensation and compromised transcription activity, pollen germination and pollen tube elongation, representing the key function of the vegetative cell in transporting sperm cells during fertilization, are inhibited in the mutant. Taken together, we conclude that SDG2-mediated H3K4me3 is an essential epigenetic mark of the gametophyte chromatin landscape, playing critical roles in gamete mitotic cell cycle progression and pollen vegetative cell function during male gametogenesis and beyond.
[Mh] Termos MeSH primário: Proteínas de Arabidopsis/metabolismo
Arabidopsis/citologia
Arabidopsis/metabolismo
Cromatina/metabolismo
Gametogênese Vegetal
Histonas/metabolismo
Lisina/metabolismo
Mitose
[Mh] Termos MeSH secundário: Arabidopsis/genética
Núcleo Celular/metabolismo
Gametogênese Vegetal/genética
Regulação da Expressão Gênica de Plantas
Germinação/genética
Heterocromatina/metabolismo
Meiose/genética
Metilação
Mitose/genética
Mutação/genética
Pólen/crescimento & desenvolvimento
Pólen/metabolismo
Tubo Polínico/genética
Tubo Polínico/crescimento & desenvolvimento
Retroelementos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (Chromatin); 0 (Heterochromatin); 0 (Histones); 0 (Retroelements); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1104/pp.17.00306


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[PMID]:29232693
[Au] Autor:Rai SK; Sangesland M; Lee M; Esnault C; Cui Y; Chatterjee AG; Levin HL
[Ad] Endereço:Section on Eukaryotic Transposable Elements, Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, United States of America.
[Ti] Título:Host factors that promote retrotransposon integration are similar in distantly related eukaryotes.
[So] Source:PLoS Genet;13(12):e1006775, 2017 12.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Retroviruses and Long Terminal Repeat (LTR)-retrotransposons have distinct patterns of integration sites. The oncogenic potential of retrovirus-based vectors used in gene therapy is dependent on the selection of integration sites associated with promoters. The LTR-retrotransposon Tf1 of Schizosaccharomyces pombe is studied as a model for oncogenic retroviruses because it integrates into the promoters of stress response genes. Although integrases (INs) encoded by retroviruses and LTR-retrotransposons are responsible for catalyzing the insertion of cDNA into the host genome, it is thought that distinct host factors are required for the efficiency and specificity of integration. We tested this hypothesis with a genome-wide screen of host factors that promote Tf1 integration. By combining an assay for transposition with a genetic assay that measures cDNA recombination we could identify factors that contribute differentially to integration. We utilized this assay to test a collection of 3,004 S. pombe strains with single gene deletions. Using these screens and immunoblot measures of Tf1 proteins, we identified a total of 61 genes that promote integration. The candidate integration factors participate in a range of processes including nuclear transport, transcription, mRNA processing, vesicle transport, chromatin structure and DNA repair. Two candidates, Rhp18 and the NineTeen complex were tested in two-hybrid assays and were found to interact with Tf1 IN. Surprisingly, a number of pathways we identified were found previously to promote integration of the LTR-retrotransposons Ty1 and Ty3 in Saccharomyces cerevisiae, indicating the contribution of host factors to integration are common in distantly related organisms. The DNA repair factors are of particular interest because they may identify the pathways that repair the single stranded gaps flanking the sites of strand transfer following integration of LTR retroelements.
[Mh] Termos MeSH primário: Fatores Hospedeiros de Integração/genética
Recombinação Genética
Retroelementos/genética
Sequências Repetidas Terminais/genética
Ubiquitina-Proteína Ligases/genética
[Mh] Termos MeSH secundário: Reparo do DNA/genética
Eucariotos/genética
Regulação Fúngica da Expressão Gênica
Integrases/genética
Regiões Promotoras Genéticas
DNA Polimerase Dirigida por RNA/genética
Retroviridae/genética
Saccharomyces cerevisiae/genética
Proteínas de Saccharomyces cerevisiae/genética
Schizosaccharomyces/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Integration Host Factors); 0 (Retroelements); 0 (Saccharomyces cerevisiae Proteins); 0 (Spp382 protein, S cerevisiae); EC 2.3.2.27 (Rhp18 protein, S pombe); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 2.7.7.- (Integrases); EC 2.7.7.49 (RNA-Directed DNA Polymerase); EC 2.7.7.49 (reverse transcriptase Ty3, S cerevisiae)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006775


  3 / 4267 MEDLINE  
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[PMID]:29198561
[Au] Autor:Chou HJ; Donnard E; Gustafsson HT; Garber M; Rando OJ
[Ad] Endereço:Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
[Ti] Título:Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation.
[So] Source:Mol Cell;68(5):978-992.e4, 2017 Dec 07.
[Is] ISSN:1097-4164
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Covalent nucleotide modifications in noncoding RNAs affect a plethora of biological processes, and new functions continue to be discovered even for well-known modifying enzymes. To systematically compare the functions of a large set of noncoding RNA modifications in gene regulation, we carried out ribosome profiling in budding yeast to characterize 57 nonessential genes involved in tRNA modification. Deletion mutants exhibited a range of translational phenotypes, with enzymes known to modify anticodons, or non-tRNA substrates such as rRNA, exhibiting the most dramatic translational perturbations. Our data build on prior reports documenting translational upregulation of the nutrient-responsive transcription factor Gcn4 in response to numerous tRNA perturbations, and identify many additional translationally regulated mRNAs throughout the yeast genome. Our data also uncover unexpected roles for tRNA-modifying enzymes in regulation of TY retroelements, and in rRNA 2'-O-methylation. This dataset should provide a rich resource for discovery of additional links between tRNA modifications and gene regulation.
[Mh] Termos MeSH primário: RNA Fúngico/metabolismo
RNA de Transferência/metabolismo
Ribossomos/enzimologia
Proteínas de Saccharomyces cerevisiae/metabolismo
Saccharomyces cerevisiae/enzimologia
Transcriptoma
tRNA Metiltransferases/metabolismo
[Mh] Termos MeSH secundário: Fatores de Transcrição de Zíper de Leucina Básica/biossíntese
Fatores de Transcrição de Zíper de Leucina Básica/genética
Perfilação da Expressão Gênica/métodos
Regulação Fúngica da Expressão Gênica
Genótipo
Metilação
Mutação
Fenótipo
RNA Fúngico/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
RNA Ribossômico/genética
RNA Ribossômico/metabolismo
RNA de Transferência/genética
RNA não Traduzido/genética
RNA não Traduzido/metabolismo
Retroelementos
Ribossomos/genética
Saccharomyces cerevisiae/genética
Proteínas de Saccharomyces cerevisiae/biossíntese
Proteínas de Saccharomyces cerevisiae/genética
Sequências Repetidas Terminais
tRNA Metiltransferases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Basic-Leucine Zipper Transcription Factors); 0 (GCN4 protein, S cerevisiae); 0 (RNA, Fungal); 0 (RNA, Messenger); 0 (RNA, Ribosomal); 0 (RNA, Untranslated); 0 (Retroelements); 0 (Saccharomyces cerevisiae Proteins); 9014-25-9 (RNA, Transfer); EC 2.1.1.- (Trm7 protein, S cerevisiae); EC 2.1.1.- (tRNA Methyltransferases)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:28459457
[Au] Autor:Hendrickson PG; Doráis JA; Grow EJ; Whiddon JL; Lim JW; Wike CL; Weaver BD; Pflueger C; Emery BR; Wilcox AL; Nix DA; Peterson CM; Tapscott SJ; Carrell DT; Cairns BR
[Ad] Endereço:Department of Oncological Sciences, Huntsman Cancer Institute and Howard Hughes Medical Institute, Salt Lake City, Utah, USA.
[Ti] Título:Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons.
[So] Source:Nat Genet;49(6):925-934, 2017 Jun.
[Is] ISSN:1546-1718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To better understand transcriptional regulation during human oogenesis and preimplantation development, we defined stage-specific transcription, which highlighted the cleavage stage as being highly distinctive. Here, we present multiple lines of evidence that a eutherian-specific multicopy retrogene, DUX4, encodes a transcription factor that activates hundreds of endogenous genes (for example, ZSCAN4, KDM4E and PRAMEF-family genes) and retroviral elements (MERVL/HERVL family) that define the cleavage-specific transcriptional programs in humans and mice. Remarkably, mouse Dux expression is both necessary and sufficient to convert mouse embryonic stem cells (mESCs) into 2-cell-embryo-like ('2C-like') cells, measured here by the reactivation of '2C' genes and repeat elements, the loss of POU5F1 (also known as OCT4) protein and chromocenters, and the conversion of the chromatin landscape (as assessed by transposase-accessible chromatin using sequencing (ATAC-seq)) to a state strongly resembling that of mouse 2C embryos. Thus, we propose mouse DUX and human DUX4 as major drivers of the cleavage or 2C state.
[Mh] Termos MeSH primário: Proteínas de Homeodomínio/metabolismo
Retroelementos/genética
[Mh] Termos MeSH secundário: Adulto
Processamento Alternativo
Animais
Blastocisto/fisiologia
Cromatina/genética
Cromatina/metabolismo
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Proteínas de Homeodomínio/genética
Seres Humanos
Camundongos Transgênicos
Oócitos/fisiologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (DUX4 protein, human); 0 (Dux4 protein, mouse); 0 (Homeodomain Proteins); 0 (Retroelements)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1038/ng.3844


  5 / 4267 MEDLINE  
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[PMID]:29045822
[Au] Autor:Fedoseeva DM; Kretova OV; Gorbacheva MA; Tchurikov NA
[Ad] Endereço:Engelhardt Institute of Molecular Biology, Moscow 119334, Russia.
[Ti] Título:Individual effects of the copia and gypsy enhancer and insulator on chromatin marks, eRNA synthesis, and binding of insulator proteins in transfected genetic constructs.
[So] Source:Gene;641:151-160, 2018 Jan 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Enhancers and insulators are involved in the regulation of gene expression, but the basic underlying mechanisms of action of these elements are unknown. We analyzed the individual effects of the enhancer and the insulator from Drosophila mobile elements copia [enh(copia)] and gypsy using transfected genetic constructs in S2 cells. This system excludes the influence of genomic cis regulatory elements. The enhancer-induced synthesis of 350-1050-nt-long enhancer RNAs (eRNAs) and H3K4me3 and H3K18ac marks, mainly in the region located about 300bp downstream of the enhancer. Insertion of the insulator between the enhancer and the promoter reduced these effects. We also observed the binding of dCTCF to the enhancer and to gypsy insulator. Our data indicate that a single gypsy insulator interacts with both the enhancer and the promoter, while two copies of the gypsy insulator preferentially interact with each other. Our results suggest the formation of chromatin loops that are shaped by the enhancer and the insulator.
[Mh] Termos MeSH primário: Cromatina/genética
Proteínas de Drosophila/genética
Drosophila/genética
Elementos Facilitadores Genéticos/genética
Marcadores Genéticos/genética
Elementos Isolantes/genética
Peptídeo Hidrolases/genética
RNA/genética
Retroelementos/genética
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Regulação da Expressão Gênica/genética
Regiões Promotoras Genéticas/genética
Elementos Reguladores de Transcrição/genética
Transfecção/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (Drosophila Proteins); 0 (Genetic Markers); 0 (Retroelements); 63231-63-0 (RNA); EC 3.4.- (Peptide Hydrolases); EC 3.4.23.- (Copia protein, Drosophila)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE


  6 / 4267 MEDLINE  
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[PMID]:29028794
[Au] Autor:Ward JR; Vasu K; Deutschman E; Halawani D; Larson PA; Zhang D; Willard B; Fox PL; Moran JV; Longworth MS
[Ad] Endereço:Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States of America.
[Ti] Título:Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells.
[So] Source:PLoS Genet;13(10):e1007051, 2017 Oct.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This work reveals that the human Condensin II complex restricts L1 retrotransposition in both non-transformed and transformed cell lines through inhibition of L1 transcription and translation. Condensin II subunits, CAP-D3 and CAP-H2, interact with members of the Gamma-Interferon Activated Inhibitor of Translation (GAIT) complex including the glutamyl-prolyl-tRNA synthetase (EPRS), the ribosomal protein L13a, Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and NS1 associated protein 1 (NSAP1). GAIT has been shown to inhibit translation of mRNAs encoding inflammatory proteins in myeloid cells by preventing the binding of the translation initiation complex, in response to Interferon gamma (IFN-γ). Excitingly, our data show that Condensin II promotes complexation of GAIT subunits. Furthermore, RNA-Immunoprecipitation experiments in epithelial cells demonstrate that Condensin II and GAIT subunits associate with L1 RNA in a co-dependent manner, independent of IFN-γ. These findings suggest that cooperation between the Condensin II and GAIT complexes may facilitate a novel mechanism of L1 repression, thus contributing to the maintenance of genome stability in somatic cells.
[Mh] Termos MeSH primário: Proteínas de Ciclo Celular/genética
Interferon gama/genética
Elementos Nucleotídeos Longos e Dispersos/genética
Proteínas Nucleares/genética
[Mh] Termos MeSH secundário: Adenosina Trifosfatases/genética
Proteínas de Ligação a DNA/genética
Células Epiteliais/metabolismo
Genoma Humano
Seres Humanos
Fator Gênico 3 Estimulado por Interferon/genética
Complexos Multiproteicos/genética
Ligação Proteica
Inibidores da Síntese de Proteínas
RNA Mensageiro/genética
Retroelementos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Cycle Proteins); 0 (DNA-Binding Proteins); 0 (Interferon-Stimulated Gene Factor 3); 0 (Multiprotein Complexes); 0 (NCAPH protein, human); 0 (Nuclear Proteins); 0 (Protein Synthesis Inhibitors); 0 (RNA, Messenger); 0 (Retroelements); 0 (chromosome-associated protein D3, human); 0 (condensin complexes); 0 (gamma interferon activation factor); 82115-62-6 (Interferon-gamma); EC 3.6.1.- (Adenosine Triphosphatases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007051


  7 / 4267 MEDLINE  
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[PMID]:29025590
[Au] Autor:Qian Y; Mancini-DiNardo D; Judkins T; Cox HC; Brown K; Elias M; Singh N; Daniels C; Holladay J; Coffee B; Bowles KR; Roa BB
[Ad] Endereço:Myriad Genetic Laboratories, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USA.
[Ti] Título:Identification of pathogenic retrotransposon insertions in cancer predisposition genes.
[So] Source:Cancer Genet;216-217:159-169, 2017 Oct.
[Is] ISSN:2210-7762
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cancer risks have been previously reported for some retrotransposon element (RE) insertions; however, detection of these insertions is technically challenging and very few oncogenic RE insertions have been reported. Here we evaluate RE insertions identified during hereditary cancer genetic testing using a comprehensive testing strategy. Individuals who had single-syndrome or pan-cancer hereditary cancer genetic testing from February 2004 to March 2017 were included. RE insertions were identified using Sanger sequencing, Next Generation Sequencing, or multiplex quantitative PCR, and further characterized using targeted PCR and sequencing analysis. Personal cancer history, ancestry, and haplotype were evaluated. A total of 37 unique RE insertions were identified in 10 genes, affecting 211 individuals. BRCA2 accounted for 45.9% (17/37) of all unique RE insertions. Several RE insertions were detected with high frequency in populations of conserved ancestry wherein up to 100% of carriers shared a high degree of haplotype conservation, suggesting founder effects. Our comprehensive testing strategy resulted in a substantial increase in the number of reported oncogenic RE insertions, several of which may have possible founder effects. Collectively, these data show that the detection of RE insertions is an important component of hereditary cancer genetic testing and may be more prevalent than previously reported.
[Mh] Termos MeSH primário: Genes Neoplásicos
Predisposição Genética para Doença
Mutagênese Insercional/genética
Neoplasias/genética
Retroelementos/genética
[Mh] Termos MeSH secundário: Elementos Alu/genética
Sequência de Bases
Efeito Fundador
Haplótipos/genética
Seres Humanos
Mutação/genética
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Retroelements)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


  8 / 4267 MEDLINE  
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[PMID]:28957425
[Au] Autor:Smith CEL; Alexandraki A; Cordery SF; Parmar R; Bonthron DT; Valleley EMA
[Ad] Endereço:School of Medicine, University of Leeds, St. James's University Hospital, Leeds, United Kingdom.
[Ti] Título:A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes.
[So] Source:PLoS One;12(9):e0185678, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The imprinted gene PLAGL1 is an important regulator of apoptosis and cell cycle arrest. Loss of its expression has been implicated in tumorigenesis in a range of different cancers, and overexpression during fetal development causes transient neonatal diabetes mellitus (TNDM). PLAGL1 lies within an imprinted region of chromosome 6q24, and monoallelic expression from the major, differentially methylated promoter (P1) occurs in most human tissues. However, in peripheral blood leukocytes, the active promoter (P2) is non-imprinted and drives biallelic transcription. We report here a novel PLAGL1 promoter (P5) derived from the insertion of a primate-specific, MIR3 SINE retrotransposon. P5 is highly utilized in lymphocytes, particularly in T cells, and like P2, directs biallelic transcription. Our results show that it is important to consider P5 in relation to PLAGL1 function in T cells when investigating the dysregulation of this gene.
[Mh] Termos MeSH primário: Alelos
Proteínas de Ciclo Celular/genética
Regiões Promotoras Genéticas
Retroelementos
Elementos Nucleotídeos Curtos e Dispersos/genética
Fatores de Transcrição/genética
Proteínas Supressoras de Tumor/genética
[Mh] Termos MeSH secundário: Linfócitos B/metabolismo
Ilhas de CpG
Seres Humanos
RNA Mensageiro/genética
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Linfócitos T/metabolismo
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Cycle Proteins); 0 (PLAGL1 protein, human); 0 (RNA, Messenger); 0 (Retroelements); 0 (Transcription Factors); 0 (Tumor Suppressor Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185678


  9 / 4267 MEDLINE  
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[PMID]:28951621
[Au] Autor:Grow EJ
[Ad] Endereço:Department of Oncological Sciences, Huntsman Cancer Institute and Howard Hughes Medical Institute, Salt Lake City, Utah, USA.
[Ti] Título:A fine LINE-1 in mouse embryonic chromatin regulation.
[So] Source:Nat Genet;49(10):1418-1419, 2017 Sep 27.
[Is] ISSN:1546-1718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The functional role of repetitive elements in mammalian genomes is still largely unexplored. A new study provides evidence that LINE-1 retrotransposons regulate chromatin dynamics and are essential for normal embryonic development in mice.
[Mh] Termos MeSH primário: Cromatina
Retroelementos
[Mh] Termos MeSH secundário: Animais
Desenvolvimento Embrionário
Genoma
Camundongos
Sequências Repetitivas de Ácido Nucleico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (Retroelements)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1038/ng.3960


  10 / 4267 MEDLINE  
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[PMID]:28867564
[Au] Autor:Mascagni F; Cavallini A; Giordani T; Natali L
[Ad] Endereço:Dept. of Agriculture, Food, and Environment, University of Pisa, Via delBorghetto 80, I-56124 Pisa, Italy.
[Ti] Título:Different histories of two highly variable LTR retrotransposons in sunflower species.
[So] Source:Gene;634:5-14, 2017 Nov 15.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the Helianthus genus, very large intra- and interspecific variability related to two specific retrotransposons of Helianthus annuus (Helicopia and SURE) exists. When comparing these two sequences to sunflower sequence databases recently produced by our lab, the Helicopia family was shown to belong to the Maximus/SIRE lineage of the Sirevirus genus of the Copia superfamily, whereas the SURE element (whose superfamily was not even previously identified) was classified as a Gypsy element of the Ogre/Tat lineage of the Metavirus genus. Bioinformatic analysis of the two retrotransposon families revealed their genomic abundance and relative proliferation timing. The genomic abundance of these families differed significantly among 12 Helianthus species. The ratio between the abundance of long terminal repeats and their reverse transcriptases suggested that the SURE family has relatively more solo long terminal repeats than does Helicopia. Pairwise comparisons of Illumina reads encoding the reverse transcriptase domain indicated that SURE amplification may have occurred more recently than that of Helicopia. Finally, the analysis of population structure based on the SURE and Helicopia polymorphisms of 32 Helianthus species evidenced two subpopulations, which roughly corresponded to species of the Helianthus and Divaricati/Ciliares sections. However, a number of species showed an admixed structure, confirming the importance of interspecific hybridisation in the evolution of this genus. In general, these two retrotransposon families differentially contributed to interspecific variability, emphasising the need to refer to specific families when studying genome evolution.
[Mh] Termos MeSH primário: Helianthus/classificação
Retroelementos
Sequências Repetidas Terminais
[Mh] Termos MeSH secundário: DNA de Plantas/genética
Evolução Molecular
Variação Genética
Helianthus/genética
Hibridização Genética
Análise de Sequência de DNA/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (Retroelements)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE



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