Base de dados : MEDLINE
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  1 / 3396 MEDLINE  
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[PMID]:28453010
[Au] Autor:Sethi S; Ooe M; Sakamoto T; Fujimoto K
[Ad] Endereço:School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan. kenzo@jaist.ac.jp.
[Ti] Título:Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside.
[So] Source:Mol Biosyst;13(6):1152-1156, 2017 Jun 01.
[Is] ISSN:1742-2051
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Photo-chemical deamination of cytosine using 3-cyanovinylcarbazole nucleoside ( K) mediated photo-cross-linking is a technique for site-directed mutagenesis. Using this technique in vivo requires the elimination of a high-temperature incubation step; instead, incubation should be carried out under physiological conditions. To improve the reactivity of K mediated photo-cross-link induced deamination of cytosine under physiological conditions, an evaluation of base pairing in cytosine was carried out with respect to its deamination. Guanine was replaced with 4 different counter bases (inosine, 2-aminopurine, 5-nitroindole, and nebularine), showing distinct hydrogen bonding patterns with target cytosine, which was incorporated at the -1 position with respect to K in the K-modified photo-responsive oligodeoxyribonucleotides to ascertain the role of hydrogen bonding in deamination under physiological conditions. Among the counter bases, inosine showed the highest acceleration towards the photo-induced deamination reaction.
[Mh] Termos MeSH primário: Citosina/química
DNA/química
Guanina/química
Nucleosídeos/química
[Mh] Termos MeSH secundário: 2-Aminopurina/química
Pareamento de Bases
Desaminação
Ligações de Hidrogênio
Indóis/química
Estrutura Molecular
Mutagênese Sítio-Dirigida
Oligodesoxirribonucleotídeos/química
Nucleosídeos de Purina/química
Ribonucleosídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoles); 0 (Nucleosides); 0 (Oligodeoxyribonucleotides); 0 (Purine Nucleosides); 0 (Ribonucleosides); 452-06-2 (2-Aminopurine); 5Z93L87A1R (Guanine); 8J337D1HZY (Cytosine); 9007-49-2 (DNA); B8B604PS4P (nebularine); O2BHX6EDBN (5-nitroindole)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1039/c7mb00082k


  2 / 3396 MEDLINE  
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[PMID]:28460347
[Au] Autor:Kumar R; Kumar M; Singh A; Singh N; Maity J; Prasad AK
[Ad] Endereço:Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India.
[Ti] Título:Synthesis of novel C-4'-spiro-oxetano-α-L-ribonucleosides.
[So] Source:Carbohydr Res;445:88-92, 2017 Jun 05.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The synthesis of novel C-4'-spiro-oxetano-α-L-ribonucleosides T and U in 39 and 45% overall yields have been achieved from 2',3',5'-tri-O-acetyl-4'-C-p-toluenesulfonyloxymethyl-ß-D-xylofuranosylthymine and 2',3',5'-tri-O-acetyl-4'-C-p-toluenesulfonyloxymethyl-ß-D-xylofuranosyluracil, respectively. Both the tosylated nucleoside precursors have been synthesized following recently developed Novozyme -435 catalyzed methodology.
[Mh] Termos MeSH primário: Ribonucleosídeos/química
Ribonucleosídeos/síntese química
Compostos de Espiro/química
[Mh] Termos MeSH secundário: Técnicas de Química Sintética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ribonucleosides); 0 (Spiro Compounds)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  3 / 3396 MEDLINE  
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[PMID]:29204644
[Au] Autor:Zhang X; Lin X; Liu Z; Wu Y; Yang Y; Ouyang W; Li W; Liu Z
[Ad] Endereço:Eye Institute of Xiamen University & Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, China.
[Ti] Título:Topical Application of Mizoribine Suppresses CD4+ T-cell-Mediated Pathogenesis in Murine Dry Eye.
[So] Source:Invest Ophthalmol Vis Sci;58(14):6056-6064, 2017 Dec 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: We investigate the effect of topical application of mizoribine (MZR) eye drops on CD4+ T-cell-mediated immunity and epithelial damage in ocular surface of dry eye disease (DED). Methods: Topical application of MZR or vehicle eye drops was performed in mice subjected to desiccating stress (DS). The phenol red cotton test was used to measure tear production, and Oregon-green-dextran (OGD) staining was performed to assess corneal epithelial barrier function. PAS staining was used to quantify conjunctival goblet cells. Immunofluorescent staining and quantitative (q) RT-PCR were used to assess the expression of matrix metalloproteinase (MMP)-9 in corneal epithelium. qRT-PCR and ELISA were used to assess the production of TNF-α and IL-1ß in conjunctiva. Apoptosis in ocular surface was assessed by TUNEL and activation of caspase-8. CD4+ T-cell-mediated immunity was evaluated by CD4 immunohistochemistry and production of T helper cytokines, including IFN-γ, IL-13, and IL-17A in conjunctiva. Results: Compared to vehicle control mice, topical MZR-treated mice showed increased tear production, decreased goblet cell loss, and improved corneal barrier function. Topical application of MZR suppressed the expression of MMP-9 in corneal epithelium and apoptosis in ocular surface, while it had no obvious effect on production of TNF-α and IL-1ß in conjunctiva. Topical application of MZR decreased CD4+ T cells infiltration, with decreased production of IFN-γ and IL-17A, and increased production of IL-13 in conjunctiva. Conclusions: Topical application of MZR could alleviate epithelial damage and CD4+ T-cell-mediated immunity in ocular surface of DED.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Síndromes do Olho Seco/tratamento farmacológico
Imunidade Celular/efeitos dos fármacos
Ribonucleosídeos/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oftálmica
Animais
Apoptose
Linfócitos T CD4-Positivos/efeitos dos fármacos
Modelos Animais de Doenças
Síndromes do Olho Seco/imunologia
Síndromes do Olho Seco/patologia
Epitélio Anterior/efeitos dos fármacos
Epitélio Anterior/metabolismo
Epitélio Anterior/patologia
Feminino
Imuno-Histoquímica
Imunossupressores/administração & dosagem
Metaloproteinase 9 da Matriz/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Soluções Oftálmicas/administração & dosagem
Lágrimas/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 0 (Ophthalmic Solutions); 0 (Ribonucleosides); 4JR41A10VP (mizoribine); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22852


  4 / 3396 MEDLINE  
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[PMID]:28628209
[Au] Autor:Meher G; Meher NK; Iyer RP
[Ad] Endereço:Spring Bank Pharmaceuticals, Inc., Milford, Massachusetts.
[Ti] Título:Nucleobase Protection of Deoxyribo- and Ribonucleosides.
[So] Source:Curr Protoc Nucleic Acid Chem;69:2.1.1-2.1.40, 2017 Jun 19.
[Is] ISSN:1934-9289
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oligonucleotides carrying a variety of chemical modifications including conjugates are finding increasing applications in therapeutics, diagnostics, functional genomics, proteomics, and as research tools in chemical and molecular biology. The successful synthesis of oligonucleotides primarily depends on the use of appropriately protected nucleoside building blocks including the exocyclic amino groups of the nucleobases, the hydroxyl groups at the 2'-, 3'-, and 5'-positions of the sugar moieties, and the internucleotide phospho-linkage. This unit is a thoroughly revised update of the previously published version and describes the recent development of various protecting groups that facilitate reliable oligonucleotide synthesis. In addition, various protecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, are described to prevent irreversible nucleobase modifications that may occur in the presence of reagents used in oligonucleotide synthesis. © 2017 by John Wiley & Sons, Inc.
[Mh] Termos MeSH primário: Desoxirribonucleosídeos/química
Ribonucleosídeos/química
[Mh] Termos MeSH secundário: Acetilação
Fotoquímica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Deoxyribonucleosides); 0 (Ribonucleosides)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1002/cpnc.32


  5 / 3396 MEDLINE  
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[PMID]:28502927
[Au] Autor:Ikeda K; Watanabe K; Hirai T; Tanji K; Miyashita T; Nakajima S; Uomori K; Morimoto S; Takamori K; Ogawa H; Takasaki Y; Sekigawa I
[Ad] Endereço:Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Japan.
[Ti] Título:Mizoribine Synchronized Methotrexate Therapy should be Considered when Treating Rheumatoid Arthritis Patients with an Inadequate Response to Various Combination Therapies.
[So] Source:Intern Med;56(10):1147-1152, 2017.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Objective The objective of this study was to confirm the efficacy of low-dose mizoribine (MZR), an inhibitor of inosine monophosphate dehydrogenase, as part of synchronized methotrexate (MTX) therapy for rheumatoid arthritis (RA) patients with an inadequate response to various combination therapies of MTX, other synthetic disease-modifying anti-rheumatic drugs (DMARDs) and biological DMARDs. Methods Low-dose MZR was administered to 56 uncontrolled RA patients being treated with MTX and various biological DMARDs. The observation period was 12 months, and the disease activity was evaluated based on the Disease Activity Score in 28 joints (DAS28)-ESR, Simplified Disease Activity Index (SDAI) and serum MMP-3 level. Results All of the disease activity indices were significantly improved within three months, and the serum MMP-3 levels were also significantly decreased around four months after starting low-dose MZR therapy. No patients experienced any adverse effects. Conclusion The present preliminary findings suggest that low-dose MZR therapy with MTX should be considered for the treatment of RA patients with an inadequate response to various combination therapies including MTX, other synthetic DMARDs and biological DMARDs or in whom increasing the dose of MTX is difficult for reasons such as adverse effects and complications.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Artrite Reumatoide/tratamento farmacológico
Metotrexato/uso terapêutico
Ribonucleosídeos/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Antirreumáticos/administração & dosagem
Relação Dose-Resposta a Droga
Quimioterapia Combinada
Feminino
Seres Humanos
Masculino
Metaloproteinase 3 da Matriz/metabolismo
Metotrexato/administração & dosagem
Meia-Idade
Projetos Piloto
Ribonucleosídeos/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antirheumatic Agents); 0 (Ribonucleosides); 4JR41A10VP (mizoribine); EC 3.4.24.17 (MMP3 protein, human); EC 3.4.24.17 (Matrix Metalloproteinase 3); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.56.7886


  6 / 3396 MEDLINE  
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[PMID]:28420174
[Au] Autor:Hu C; Ruan Z; Ding H; Zhou Y; Xiao Q
[Ad] Endereço:Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, China. nchuchen@yahoo.com.
[Ti] Título:An Expedient Total Synthesis of Triciribine.
[So] Source:Molecules;22(4), 2017 Apr 17.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the present paper, we report an expedient total synthesis of triciribine, a tricyclic 7-deazapurine nucleoside and protein kinase B (AKT ) inhibitor, in 35% overall yield. Our synthesis route features a highly regioselective substitution of 1- -Boc-2-methylhydrazine and a trifluoroacetic acid catalyzed one-pot transformation which combined the deprotection of the -butylcarbonyl (Boc) group and ring closure reaction together to give a tricyclic nucleobase motif.
[Mh] Termos MeSH primário: Ribonucleosídeos/síntese química
[Mh] Termos MeSH secundário: Técnicas de Química Sintética
Modelos Moleculares
Estrutura Molecular
Nucleosídeos/síntese química
Inibidores de Proteínas Quinases/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nucleosides); 0 (Protein Kinase Inhibitors); 0 (Ribonucleosides); 2421HMY9N6 (triciribine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


  7 / 3396 MEDLINE  
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[PMID]:28324644
[Au] Autor:Huchting J; Winkler M; Nasser H; Meier C
[Ad] Endereço:Organic Chemistry, Department of Chemistry, Faculty of Sciences, Hamburg University, Martin-Luther-King-Platz 6, 20146, Hamburg, Germany.
[Ti] Título:Synthesis of T-705-Ribonucleoside and T-705-Ribonucleotide and Studies of Chemical Stability.
[So] Source:ChemMedChem;12(9):652-659, 2017 May 09.
[Is] ISSN:1860-7187
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:T-705 (favipiravir) is a fluorinated hydroxypyrazine carboxamide that exhibits antiviral activities against a variety of RNA viruses. Given the lack of potent agents to combat these infections caused by a large number of high-impact pathogens, significant emphasis has been put on studies of the antiviral properties of T-705 and its mechanism of action. T-705 acts as a nucleobase analogue; it is therefore metabolized to the corresponding ribonucleoside triphosphate intracellularly. Herein we report a reliable synthesis of T-705-ribonucleoside as well as its 5'-monophosphate. Moreover, we disclose detailed studies on the remarkable lability of the heterocycle when attached to ribose under very mild conditions, as typically applied in biochemical studies.
[Mh] Termos MeSH primário: Ribonucleosídeos/síntese química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cristalografia por Raios X
Espectroscopia de Ressonância Magnética
Conformação de Ácido Nucleico
Ribonucleosídeos/química
Espectrometria de Massas por Ionização por Electrospray
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ribonucleosides)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1002/cmdc.201700116


  8 / 3396 MEDLINE  
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[PMID]:28235707
[Au] Autor:Camero M; Buonavoglia D; Lucente MS; Losurdo M; Crescenzo G; Trerotoli P; Casalino E; Martella V; Elia G; Tempesta M
[Ad] Endereço:Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.
[Ti] Título:Enhancement of the antiviral activity against caprine herpesvirus type 1 of Acyclovir in association with Mizoribine.
[So] Source:Res Vet Sci;111:120-123, 2017 Apr.
[Is] ISSN:1532-2661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Caprine herpesvirus 1 (CpHV-1) infection in goats is responsible for genital lesions resembling the lesions induced by herpesvirus 2 in humans (HHV-2). The immunosuppressive drug Mizoribine (MIZ) is able to increase the antiviral activity of Acyclovir (ACV) against herpesvirus infections, raising interesting perspectives on new combined therapeutic strategies. In this study the anti-CpHV-1 activity in vitro of ACV alone or in combination with MIZ was evaluated. ACV (100µg/ml) displayed an antiviral effect on CpHV-1 replication. This inhibitory effect was higher when ACV (100µg/ml) was used in association with MIZ (20µg/ml). Other combinations of ACV and MIZ in various concentrations were not as effective as ACV 100µg/ml/MIZ 20µg/ml. These findings suggest that the association of ACV and MIZ is potentially useful for treatment of genital infection by herpesviruses.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Antivirais/farmacologia
Doenças das Cabras/tratamento farmacológico
Infecções por Herpesviridae/veterinária
Imunossupressores/farmacologia
Ribonucleosídeos/farmacologia
Varicellovirus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Bovinos
Linhagem Celular
Doenças das Cabras/virologia
Cabras
Infecções por Herpesviridae/tratamento farmacológico
Infecções por Herpesviridae/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Immunosuppressive Agents); 0 (Ribonucleosides); 4JR41A10VP (mizoribine); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


  9 / 3396 MEDLINE  
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[PMID]:28221790
[Au] Autor:Tichý M; Smolen S; Tloust'ová E; Pohl R; Ozdian T; Hejtmánková K; Lisková B; Gurská S; Dzubák P; Hajdúch M; Hocek M
[Ad] Endereço:Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Gilead Sciences & IOCB Research Center , Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.
[Ti] Título:Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides.
[So] Source:J Med Chem;60(6):2411-2424, 2017 Mar 23.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2',3':4,5]pyrrolo[2,3-d]pyrimidines and thieno[3',2':4,5]pyrrolo[2,3-d]pyrimidines) were synthesized by a sequence involving Negishi coupling of 4,6-dichloropyrimidine with iodothiophenes, nucleophilic azidation, and cyclization of tetrazolopyrimidines, followed by glycosylation and cross-couplings or nucleophilic substitutions at position 4. Most nucleosides (from both isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activities against a broad panel of cancer and leukemia cell lines and some antiviral activity against HCV. The most active were the 6-methoxy, 6-methylsulfanyl, and 6-methyl derivatives, which were highly active to cancer cells and less toxic or nontoxic to fibroblasts.
[Mh] Termos MeSH primário: Antineoplásicos/química
Antineoplásicos/farmacologia
Antivirais/química
Antivirais/farmacologia
Purinas/química
Purinas/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antivirais/síntese química
Linhagem Celular Tumoral
Hepacivirus/efeitos dos fármacos
Hepatite C/tratamento farmacológico
Seres Humanos
Neoplasias/tratamento farmacológico
Purinas/síntese química
Ribonucleosídeos/síntese química
Ribonucleosídeos/química
Ribonucleosídeos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (7-deazapurine); 0 (Antineoplastic Agents); 0 (Antiviral Agents); 0 (Purines); 0 (Ribonucleosides)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.6b01766


  10 / 3396 MEDLINE  
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[PMID]:28210092
[Au] Autor:Higashi H; Obara H; Miyakoshi K; Shinoda M; Kitago M; Shimojima N; Abe Y; Hibi T; Yagi H; Matsubara K; Yamada Y; Itano O; Hoshino K; Kuroda T; Kitagawa Y
[Ad] Endereço:Hisanobu Higashi, Hideaki Obara, Masahiro Shinoda, Minoru Kitago, Yuta Abe, Taizo Hibi, Hiroshi Yagi, Kentaro Matsubara, Osamu Itano, Yuko Kitagawa, Department of Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
[Ti] Título:First successful perinatal management of pregnancy after ABO-incompatible liver transplantation.
[So] Source:World J Gastroenterol;23(3):547-550, 2017 Jan 21.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many papers have reported on pregnancy and delivery after liver transplantation, but there have been no reports on pregnancy after ABO-incompatible liver transplantation. This paper reports the first successful pregnancy and delivery of a newborn after ABO-incompatible liver transplantation for fulminant hepatic failure. The patient was a 39-year-old female. She had an ABO-incompatible liver transplantation, donated from her husband, due to subacute fulminant hepatitis of unknown etiology. She was taking tacrolimus, methylprednisolone, and mizoribine orally for the maintenance of immunosuppression at the time of discharge. She was discharged uneventfully on postoperative day 38 without any rejection episodes. At 1 year and 6 mo after transplantation, she indicated a wish to become pregnant. Therefore, treatment with mycophenolate mofetil was interrupted at that time. After two miscarriages, she finally became pregnant and delivered transvaginally 3 years after the transplantation. All of the pregnancies were conceived naturally. The newborn was female with a birth weight of 3146 g; the Apgar scores were 9 and 10. Delivery was performed smoothly, and the newborn exhibited no malformations. The mother and the newborn were discharged uneventfully. We suggest that pregnancy is possible for recipients after ABO-incompatible liver transplantation.
[Mh] Termos MeSH primário: Sistema do Grupo Sanguíneo ABO/efeitos adversos
Incompatibilidade de Grupos Sanguíneos/complicações
Encefalopatia Hepática/terapia
Hepatite/complicações
Imunossupressores/uso terapêutico
Transplante de Fígado/efeitos adversos
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Índice de Apgar
Biópsia
Incompatibilidade de Grupos Sanguíneos/sangue
Incompatibilidade de Grupos Sanguíneos/tratamento farmacológico
Parto Obstétrico
Feminino
Hemodiafiltração
Encefalopatia Hepática/sangue
Encefalopatia Hepática/etiologia
Encefalopatia Hepática/patologia
Seres Humanos
Imunossupressão/métodos
Imunossupressores/administração & dosagem
Recém-Nascido
Doadores Vivos
Metilprednisolona/administração & dosagem
Metilprednisolona/uso terapêutico
Gravidez
Ribonucleosídeos/administração & dosagem
Ribonucleosídeos/uso terapêutico
Rituximab/administração & dosagem
Rituximab/uso terapêutico
Cônjuges
Tacrolimo/administração & dosagem
Tacrolimo/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ABO Blood-Group System); 0 (Immunosuppressive Agents); 0 (Ribonucleosides); 4F4X42SYQ6 (Rituximab); 4JR41A10VP (mizoribine); WM0HAQ4WNM (Tacrolimus); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v23.i3.547



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