Base de dados : MEDLINE
Pesquisa : D20.215.721 [Categoria DeCS]
Referências encontradas : 457 [refinar]
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[PMID]:29240415
[Au] Autor:Fu QL; Blaney L; Zhou DM
[Ad] Endereço:Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences , Nanjing, Jiangsu 210008, People's Republic of China.
[Ti] Título:Identifying Plant Stress Responses to Roxarsone in Soybean Root Exudates: New Insights from Two-Dimensional Correlation Spectroscopy.
[So] Source:J Agric Food Chem;66(1):53-62, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Roxarsone (ROX) is an organoarsenic feed additive of increasing interest used in the poultry industry. Soybean responses to ROX stress were investigated in root exudates (REs) using two-dimensional correlation spectroscopy (2D-COS) with fluorescence and Fourier transform infrared spectra. Environmentally relevant ROX concentrations caused negligible toxicity to crop growth and photosynthesis activity but blackened soybean roots at high concentrations. 2D-COS analysis revealed that the protein-like fluorophore and C═C and C═O, aliphatic OH, and polysaccharide C-O-H moieties in soybean REs were most sensitive to ROX stress. Heterospectral 2D-COS results suggested that aromatic, amide I, quinone, ketone, and aliphatic functional groups were the foundational components of protein-like and short-wavelength excited humic-like fluorophores in soybean REs. Carboxyl and phenolic moieties were related to the long-wavelength excited humic-like fluorophore. Overall, 2D-COS combined with molecular-based spectral analysis of REs provided an innovative approach to characterize the physiological responses of crops to contaminants at sublethal levels.
[Mh] Termos MeSH primário: Raízes de Plantas/efeitos dos fármacos
Roxarsona/farmacologia
Feijão de Soja/efeitos dos fármacos
Espectrometria de Fluorescência/métodos
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
[Mh] Termos MeSH secundário: Arsênico/metabolismo
Clorofila/metabolismo
Cromatografia Líquida de Alta Pressão
Coccidiostáticos/farmacologia
Poluentes Ambientais/farmacocinética
Poluentes Ambientais/farmacologia
Espectrometria de Massas
Exsudatos de Plantas/química
Exsudatos de Plantas/metabolismo
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Roxarsona/farmacocinética
Feijão de Soja/química
Feijão de Soja/metabolismo
Estresse Fisiológico/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coccidiostats); 0 (Environmental Pollutants); 0 (Plant Exudates); 1406-65-1 (Chlorophyll); H5GU9YQL7L (Roxarsone); N712M78A8G (Arsenic)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04706


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[PMID]:28880896
[Au] Autor:Song S; Lin F; Zhu P; Wu C; Zhao S; Han Q; Li X
[Ad] Endereço:Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, Shandong, China.
[Ti] Título:Extract of Spatholobus suberctus Dunn ameliorates ischemia-induced injury by targeting miR-494.
[So] Source:PLoS One;12(9):e0184348, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cerebral stroke is a leading cause of death and permanent disability. The current therapeutic outcome of ischemic stroke (>85% of all strokes) is very poor, thus novel therapeutic drug is urgently needed. In vitro cell model of ischemia was established by oxygen-glucose deprivation (OGD) and in vivo animal model of ischemia was established by middle cerebral artery occlusion (MCAO). The effects of Spatholobus suberctus Dunn extract (SSCE) on OGD-induced cell injury, MCAO-induced neural injury and miR-494 level were all evaluated. The possible target genes were virtually screened utilizing bioinformatics and verified by luciferase assay. Subsequently, the effects of abnormally expressed miR-494 on OGD-induced cell injury and target gene expression were determined. Additionally, whether SSCE affected target gene expression through modulation of miR-494 was studied. Finally, the effects of aberrantly expressed Sox8 on OGD-induced injury and signaling pathways were estimated. SSCE reduced OGD-induced cell injury and ameliorated MCAO-induced neuronal injury, along with down-regulation of miR-494. Then, OGD-induced cell injury was increased by miR-494 overexpression but decreased by miR-494 silence. Sox8 was a target gene of miR-494, and SSCE could up-regulate Sox8 expression via down-regulating miR-494. Afterwards, OGD-induced cell injury was proved to be increased by Sox8 inhibition but reduced by Sox8 overexpression. Finally, OGD-induced inhibition of PI3K/AKT/mTOR and MAPK pathways was further inhibited by Sox8 silence but activated by Sox8 overexpression. SSCE ameliorates ischemia-induced injury both in vitro and in vivo by miR-494-mediated modulation of Sox8, involving activations of PI3K/AKT/mTOR and MAPK pathways.
[Mh] Termos MeSH primário: Isquemia Encefálica/tratamento farmacológico
Fabaceae/química
MicroRNAs/metabolismo
Exsudatos de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Western Blotting
Isquemia Encefálica/genética
Isquemia Encefálica/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Masculino
MicroRNAs/genética
Células PC12
Exsudatos de Plantas/química
Ratos
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Sincalida/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN494 microRNA, rat); 0 (MicroRNAs); 0 (Plant Exudates); M03GIQ7Z6P (Sincalide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184348


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[PMID]:28704790
[Au] Autor:Bigagli E; Cinci L; D'Ambrosio M; Luceri C
[Ad] Endereço:Department of Neuroscience, Psychology, Drug Research and Child Health, NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale G. Pieraccini 6, Florence, Italy.
[Ti] Título:Pharmacological activities of an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells.
[So] Source:J Photochem Photobiol B;173:618-625, 2017 Aug.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Ultraviolet B (UVB) exposure is a risk factor for corneal damage resulting in oxidative stress, inflammation and cell death. The aim of this study was to investigate the potential protective effects of a commercial eye drop (Dacriovis™) containing Matricaria chamomilla and Euphrasia officinalis extracts on human corneal epithelial cells (HCEC-12) against UVB radiation-induced oxidative stress and inflammation as well as the underlying mechanisms. The antioxidant potential of the eye drops was evaluated by measuring the ferric reducing antioxidant power and the total phenolic content by Folin-Ciocalteu reagent. HCEC-12 cells were exposed to UVB radiation and treated with the eye drops at various concentrations. Cell viability, wound healing assay, reactive oxygen species (ROS) levels, protein and lipid oxidative damage and COX-2, IL-1ß, iNOS, SOD-2, HO-1 and GSS gene expression, were assessed. Eye drops were able to protect corneal epithelial cells from UVB-induced cell death and ameliorated the wound healing; the eye drops exhibited a strong antioxidant activity, decreasing ROS levels and protein and lipid oxidative damage. Eye drops also exerted anti-inflammatory activities by decreasing COX-2, IL-1ß, iNOS expression, counteracted UVB-induced GSS and SOD-2 expression and restored HO-1 expression to control levels. These findings suggest that an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts exerts positive effects against UVB induced oxidative stress and inflammation and may be useful in protecting corneal epithelial cells from UVB exposure.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Euphrasia/química
Matricaria/química
Soluções Oftálmicas/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Exsudatos de Plantas/química
Raios Ultravioleta
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Antioxidantes/química
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos da radiação
Córnea/citologia
Córnea/efeitos dos fármacos
Córnea/metabolismo
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/metabolismo
Euphrasia/metabolismo
Expressão Gênica/efeitos dos fármacos
Expressão Gênica/efeitos da radiação
Heme Oxigenase-1/metabolismo
Seres Humanos
Inflamação/patologia
Inflamação/prevenção & controle
Interleucina-1beta/genética
Interleucina-1beta/metabolismo
Matricaria/metabolismo
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Soluções Oftálmicas/química
Estresse Oxidativo/efeitos da radiação
Carbonilação Proteica/efeitos dos fármacos
Carbonilação Proteica/efeitos da radiação
Espécies Reativas de Oxigênio/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Interleukin-1beta); 0 (Ophthalmic Solutions); 0 (Plant Exudates); 0 (Reactive Oxygen Species); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.14.18 (HMOX1 protein, human); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.99.1 (Cyclooxygenase 2); EC 1.14.99.1 (PTGS2 protein, human); EC 1.15.1.1 (Superoxide Dismutase); EC 1.15.1.1 (superoxide dismutase 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE


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[PMID]:28657207
[Au] Autor:Kus PM; Jerkovic I; Marijanovic Z; Tuberoso CIG
[Ad] Endereço:Department of Pharmacognosy, Wroclaw Medical University, ul. Borowska 211a, 50-556, Wroclaw, Poland.
[Ti] Título:Screening of Polish Fir Honeydew Honey Using GC/MS, HPLC-DAD, and Physical-Chemical Parameters: Benzene Derivatives and Terpenes as Chemical Markers.
[So] Source:Chem Biodivers;14(9), 2017 Sep.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:GC/MS of headspace solid phase micro extraction (HS-SPME) and solvent extractives along with targeted HPLC-DAD of Polish fir (Abies alba Mill.) honeydew honey (FHH), were used to determine the chemical profiles and potential markers of botanical origin. Additionally, typical physical-chemical parameters were also assigned. The values determined for FHH were: conductivity (1.2 mS/cm), water content (16.7 g/100 g), pH (4.5), and CIE chromaticity coordinates (L* = 48.4, a* = 20.6, b* = 69.7, C* = 72.9, and h° = 73.5). FHH contained moderate-high total phenolic content (533.2 mg GAE/kg) and antioxidant activity (1.1 mmol TEAC/kg) and (3.2 mmol Fe /kg) in DPPH and FRAP assays. The chemical profiles were dominated by source plant-originated benzene derivatives: 3,4-dihydroxybenzoic acid (up to 8.7 mg/kg, HPLC/honey solution), methyl syringate (up to 14.5%, GC/solvent extracts) or benzaldehyde (up to 43.7%, GC/headspace). Other markers were terpenes including norisoprenoid (4-hydroxy-3,5,6-trimethyl-4-(3-oxobut-1-enyl)cyclohex-2-en-1-one, up to 20.3%, GC/solvent extracts) and monoterpenes, mainly linalool derivatives (up to 49%, GC/headspace) as well as borneol (up to 5.9%, GC/headspace). The application of various techniques allowed comprehensive characterisation of FHH. 4-Hydroxy-3,5,6-trimethyl-4-(3-oxobut-1-enyl)cyclohex-2-en-1-one, coniferyl alcohol, borneol, and benzaldehyde were first time proposed for FHH screening. Protocatechuic acid may be a potential marker of FFH regardless of the geographical origin.
[Mh] Termos MeSH primário: Abies/química
Antioxidantes/análise
Derivados de Benzeno/análise
Exsudatos de Plantas/química
Terpenos/análise
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Antioxidantes/farmacologia
Derivados de Benzeno/farmacologia
Cromatografia Líquida de Alta Pressão
Cromatografia Gasosa-Espectrometria de Massas
Exsudatos de Plantas/farmacologia
Polônia
Microextração em Fase Sólida
Terpenos/farmacologia
Compostos Orgânicos Voláteis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzene Derivatives); 0 (Plant Exudates); 0 (Terpenes); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700179


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[PMID]:28560894
[Au] Autor:Lopisso DT; Knüfer J; Koopmann B; von Tiedemann A
[Ad] Endereço:Department of Crop Sciences, Division of Plant Pathology and Crop Protection, Georg August University, Grisebachstr. 6, 37077 Göttingen, Germany.
[Ti] Título:Growth of Verticillium longisporum in Xylem Sap of Brassica napus is Independent from Cultivar Resistance but Promoted by Plant Aging.
[So] Source:Phytopathology;107(9):1047-1054, 2017 09.
[Is] ISSN:0031-949X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As Verticillium stem striping of oilseed rape (OSR), a vascular disease caused by Verticillium longisporum, is extending into new geographic regions and no control with fungicides exists, the demand for understanding mechanisms of quantitative resistance increases. Because V. longisporum is strictly limited to the xylem and resistance is expressed in the systemic stage post root invasion, we investigated a potential antifungal role of soluble constituents and nutritional conditions in xylem sap as determinants of cultivar resistance of OSR to V. longisporum. Assessment of biometric and molecular genetic parameters applied to describe V. longisporum resistance (net area under disease progress curve, stunting, stem thickness, plant biomass, and V. longisporum DNA content) showed consistent susceptibility of cultivar 'Falcon' in contrast to two resistant genotypes, 'SEM' and 'Aviso'. Spectrophotometric analysis revealed a consistently stronger in vitro growth of V. longisporum in xylem sap extracted from OSR compared with the water control. Further comparisons of fungal growth in xylem sap of different cultivars revealed the absence of constitutive or V. longisporum induced antifungal activity in the xylem sap of resistant versus susceptible genotypes. The similar growth of V. longisporum in xylem sap, irrespective of cultivar, infection with V. longisporum and xylem sap filtration, was correlated with about equal amounts of total soluble proteins in xylem sap from these treatments. Interestingly, compared with younger plants, xylem sap from older plants induced significantly stronger fungal growth. Growth enhancement of V. longisporum in xylem sap of aging plants was reflected by increased contents of carbohydrates, which was consistent in mock or V. longisporum-infected plants and independent from cultivar resistance. The improved nutritional conditions in the xylem of more mature plants may explain the late appearance of disease symptoms, which are observed only in late maturity stages of plants in the field. While falsifying the presence of antifungal activity in xylem sap of resistant cultivars, this study strengthens previous findings that indicated a significant role of physical cell wall bound resistance factors involved in quantitative, cultivar-related resistance of B. napus to V. longisporum.
[Mh] Termos MeSH primário: Brassica napus/microbiologia
Exsudatos de Plantas/fisiologia
Verticillium/fisiologia
Xilema/fisiologia
[Mh] Termos MeSH secundário: Brassica napus/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Exudates)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1094/PHYTO-02-17-0043-R


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[PMID]:28273885
[Au] Autor:Kucharska AZ; Sokól-Letowska A; Oszmianski J; Piórecki N; Fecka I
[Ad] Endereço:Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wroclaw University of Environmental and Life Science, Chelmonskiego 37, 51-630 Wroclaw, Poland. alicja.kucharska@upwr.edu.pl.
[Ti] Título:Iridoids, Phenolic Compounds and Antioxidant Activity of Edible Honeysuckle Berries (Lonicera caerulea var. kamtschatica Sevast.).
[So] Source:Molecules;22(3), 2017 Mar 05.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Iridoid and polyphenol profiles of 30 different honeysuckle berry cultivars and genotypes were studied. Compounds were identified by ultra-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UPLC-ESI-qTOF-MS/MS) in positive and negative ion modes and quantified by HPLC-PDA. The 50 identified compounds included 15 iridoids, 6 anthocyanins, 9 flavonols, 2 flavanonols (dihydroflavonols), 5 flavones, 6 flavan-3-ols, and 7 phenolic acids. 8- -Loganic acid, pentosyl-loganic acid, taxifolin 7- -dihexoside, and taxifolin 7- -hexoside were identified in honeysuckle berries for the first time. Iridoids and anthocyanins were the major groups of bioactive compounds of honeysuckle constituents. The total content of quantified iridoids and anthocyanins was between 128.42 mg/100 g fresh weight (fw) ('Dlinnoplodnaya') and 372 mg/100 g fw ('Kuvshinovidnaya') and between 150.04 mg/100 g fw ('Karina') and 653.95 mg/100 g fw ('Amur'), respectively. Among iridoids, loganic acid was the dominant compound, and it represented between 22% and 73% of the total amount of quantified iridoids in honeysuckle berry. A very strong correlation was observed between the antioxidant potential and the quantity of anthocyanins. High content of iridoids in honeysuckle berries can complement antioxidant properties of phenolic compounds.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Frutas/química
Iridoides/química
Lonicera/química
Fenóis/química
Exsudatos de Plantas/química
Exsudatos de Plantas/farmacologia
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Radicais Livres/antagonistas & inibidores
Compostos Fitoquímicos/química
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Free Radicals); 0 (Iridoids); 0 (Phenols); 0 (Phytochemicals); 0 (Plant Exudates)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:28242413
[Au] Autor:Tremblay RR; Bourassa S; Nehmé B; Calvo EL
[Ad] Endereço:CHUL Research Center in Reproduction, Centre de Recherche du CHU de Québec,2705 Boulevard Laurier, Suite T3-67, Quebec City, QC, G1 V 4G2, Canada. Electronic address: roland.r.tremblay@crchudequebec.ulaval.ca.
[Ti] Título:Daylily protein constituents of the pollen and stigma a proteomics approach.
[So] Source:J Plant Physiol;212:1-12, 2017 May.
[Is] ISSN:1618-1328
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study was aimed at the identification and quantification of the protein components of the pollen grains in parallel with the distal stigmatic tissue of tetraploid cultivars. Proteomes were analyzed using iTRAQ 4plex labeling, peptides separation by online RP-nano-LC and analysis by ESI-MS/MS. Protein identification and quantification were made using the Asparagales database as a reference. A total of 524,037 MS/MS spectra were produced from pollen and stigma samples. From these, a total of 8368 peptides wereidentified corresponding to 994 unique peptides and 432 protein groups. Among them, 128 differentially expressed proteins were retained for further analysis. In absence of the daylily genome availability, we exploited numerous databases and bioinformatics resources to exploring the putative biological functions of these proteins. The profile of differentially expressed proteins suggests an important representation of functions associated to the signalling and response against endogenous and environmental stresses, including several enzymes implicated in the biosynthesis of antibiotics. The abundance in stigma of several structural proteins of the ribosomal sub-units as well as of the core histones suggest that the translation processes and the regulation of gene expression in stigma is a more active mechanism than in pollen. In addition, pollen prioritizes the synthesis of fructose and glucose as opposed to sucrose in stigma as a source of energy. Finally, the modulated proteins in Hemerocallis point to several pathways that give potential clues concerning the molecular mechanisms underlying the functions of the pollen and the stigmatic fluid in daylily reproduction.
[Mh] Termos MeSH primário: Flores/metabolismo
Hemerocallis/química
Exsudatos de Plantas/metabolismo
Proteínas de Plantas/metabolismo
Pólen/metabolismo
Proteômica
[Mh] Termos MeSH secundário: Biologia Computacional
Frutose/metabolismo
Regulação da Expressão Gênica de Plantas
Glucose/metabolismo
Hemerocallis/genética
Hemerocallis/metabolismo
Redes e Vias Metabólicas
Exsudatos de Plantas/química
Proteínas de Plantas/isolamento & purificação
Proteínas de Plantas/fisiologia
Mapas de Interação de Proteínas
Proteoma/metabolismo
Sacarose/metabolismo
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Exudates); 0 (Plant Proteins); 0 (Proteome); 30237-26-4 (Fructose); 57-50-1 (Sucrose); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE


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[PMID]:28215609
[Au] Autor:Charnikhova TV; Gaus K; Lumbroso A; Sanders M; Vincken JP; De Mesmaeker A; Ruyter-Spira CP; Screpanti C; Bouwmeester HJ
[Ad] Endereço:Laboratory of Plant Physiology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
[Ti] Título:Zealactones. Novel natural strigolactones from maize.
[So] Source:Phytochemistry;137:123-131, 2017 May.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the root exudate and root extracts of maize hybrid cv NK Falkone seven putative strigolactones were detected using UPLC-TQ-MS-MS. All seven compounds displayed MS-MS-fragmentation common for strigolactones and particularly the presence of a fragment of m/z 97 Da, which may indicate the presence of the so-called D-ring, suggests they are strigolactones. The levels of all these putative strigolactones increased upon phosphate starvation and decreased upon fluridone (carotenoid biosynthesis inhibitor) treatment, both of which are a common response for strigolactones. All seven compounds were subsequently isolated with prep-HPLC-MS. They all exhibited Striga hermonthica seed germination inducing activity just as the synthetic strigolactone analog GR24. The structure of two of the seven compounds was elucidated by NMR spectroscopy as: methyl (2E,3E)-4-(3,3-dimethyl-5-oxo-2-(prop-1-en-2-yl)tetrahydrofuran-2-yl)-2-(((4-methyl-5-oxo-2,5-dihydrofuran-2-yl)oxy)methylene)but-3-enoate (two diastereomers 1a and 1b). Strigolactones (1a/b) are closely related to the methyl ester of carlactonoic acid (MeCLA) and heliolactone. However, they contain a unique 4,4-dimethyltetrahydrofuran-2-one motif as the "A-ring" instead of the classical (di)methylcyclohexene. Because these compounds were isolated from maize (Zea mays) we called them "zealactone 1a and 1b". The implications of this discovery for our view on strigolactones and their biosynthesis are discussed.
[Mh] Termos MeSH primário: 4-Butirolactona/análogos & derivados
Lactonas/química
Exsudatos de Plantas/química
Raízes de Plantas/química
Zea mays/química
[Mh] Termos MeSH secundário: 4-Butirolactona/química
4-Butirolactona/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Germinação/efeitos dos fármacos
Lactonas/isolamento & purificação
Estrutura Molecular
Sementes/efeitos dos fármacos
Striga/efeitos dos fármacos
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lactones); 0 (Plant Exudates); OL659KIY4X (4-Butyrolactone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:28167113
[Au] Autor:Sethi S; Khurana RK; Kamboj S; Sharma R; Singh A; Rana V
[Ad] Endereço:Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
[Ti] Título:Investigating the potential of Tamarindus indica pectin-chitosan conjugate for reducing recovery period in TNBS induced colitis.
[So] Source:Int J Biol Macromol;98:739-747, 2017 May.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study was aimed at exploiting the wound healing applications and tablet coating potential of Tamarindus indica pectin-chitosan (PCH) conjugate for reducing recovery period from TNBS induced colitis. The PCH (60:40, 3% w/v) solution when spray coated followed by drying at 50°C created hydrophobic surface, that may be due to interaction of pectin with chitosan as evident from temperature ramping rheological investigations. Further, the 15% w/v coating was sufficient to prevent Mesalamine (Ma) release in pH 1.2. The AUC and AUMC of PCH coated tablets were 1.98 and 17.69 fold increased as compared to uncoated tablets. A synergistic therapeutic effect of PCH conjugate with Ma was evident from the colon/body weight ratio, clinical activity and damage score. Overall, the findings suggested PCH and Ma (20mg) reduces the recovery period from 5 to 4days with reduction in dose.
[Mh] Termos MeSH primário: Quitosana/administração & dosagem
Colite/tratamento farmacológico
Pectinas/administração & dosagem
Exsudatos de Plantas/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Quitosana/química
Colite/induzido quimicamente
Modelos Animais de Doenças
Sistemas de Liberação de Medicamentos
Seres Humanos
Pectinas/química
Exsudatos de Plantas/química
Ratos
Comprimidos/administração & dosagem
Comprimidos/química
Tamarindus/química
Ácido Trinitrobenzenossulfônico/toxicidade
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pectins); 0 (Plant Exudates); 0 (Tablets); 89NA02M4RX (pectin); 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE


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[PMID]:28146110
[Au] Autor:Bahar E; Lee GH; Bhattarai KR; Lee HY; Choi MK; Rashid HO; Kim JY; Chae HJ; Yoon H
[Ad] Endereço:College of Pharmacy, Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Gyeongnam, Korea. entaz_bahar@yahoo.com.
[Ti] Título:Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis.
[So] Source:Int J Mol Sci;18(2), 2017 Jan 30.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Manganese (Mn) is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While essential in trace amounts, excess levels of Mn in human brain can produce neurotoxicity, including idiopathic Parkinson's disease (PD)-like extrapyramidal manganism symptoms. This study aimed to investigate the protective role of polyphenolic extract of Euphorbia supina (PPEES) on Mn-induced neurotoxicity and the underlying mechanism in human neuroblastoma SKNMC cells and Sprague-Dawley (SD) male rat brain. PPEES possessed significant amount of total phenolic and flavonoid contents. PPEES also showed significant antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and reducing power capacity (RPC) assays. Our results showed that Mn treatment significantly reduced cell viability and increased lactate dehydrogenase (LDH) level, which was attenuated by PPEES pretreatment at 100 and 200 µg/mL. Additionally, PPEES pretreatment markedly attenuated Mn-induced antioxidant status alteration by resolving the ROS, MDA and GSH levels and SOD and CAT activities. PPEES pretreatment also significantly attenuated Mn-induced mitochondrial membrane potential (ΔΨm) and apoptosis. Meanwhile, PPEES pretreatment significantly reversed the Mn-induced alteration in the GRP78, GADD34, XBP-1, CHOP, Bcl-2, Bax and caspase-3 activities. Furthermore, administration of PPEES (100 and 200 mg/kg) to Mn exposed rats showed improvement of histopathological alteration in comparison to Mn-treated rats. Moreover, administration of PPEES to Mn exposed rats showed significant reduction of 8-OHdG and Bax immunoreactivity. The results suggest that PPEES treatment reduces Mn-induced oxidative stress and neuronal cell loss in SKNMC cells and in the rat brain. Therefore, PPEES may be considered as potential treat-ment in Mn-intoxicated patients.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Euphorbia/química
Manganês/metabolismo
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Exsudatos de Plantas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Biomarcadores
Linhagem Celular
Flavonoides/química
Seres Humanos
Masculino
Manganês/toxicidade
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/farmacologia
Fenol/química
Exsudatos de Plantas/química
Ratos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Flavonoids); 0 (Neuroprotective Agents); 0 (Plant Exudates); 0 (Reactive Oxygen Species); 339NCG44TV (Phenol); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE



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