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[PMID]:29446584
[Au] Autor:Sosedova LM; Novikov MA; Titov EA; Rukavishnikov VS
[Ti] Título:[Induction of apoptosis in neurons of white rats under exposure of nanobiocomposite based on ag (0) nanoparticles and arabinogalactan].
[So] Source:Gig Sanit;95(12):1210-13, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There are presented results of the immunohistochemical study of neural tissue of outbred albino rats exposed for 9 days to the influence of the silver nanobiocomposite consisted of silver nanoparticles encapsulated into a matrix of a natural polymer - arabinogalactan. The research of albino rats was performed in 2 stages: half of the rats in each groups were decapitated immediately after the exposure (early period) and the rest animals - 6 months after the end of exposure (remote period). The impact of the studied substance was proved to cause functional changes in cells of the nervous tissue. After the subacute administration of the nanobiocomposite - argentum-arabinogalactan (nano-Ag-AG) in cells of the nervous tissue of the brain of albino rats the expression of apoptotic and anti-apoptotic protein (caspase-3 and bcl-2) was established to be changed. The number of normal neurons producing protein caspase-3 sharply increases. Herewith the number of immunonegative neurons fairly declines. Along with this there is noted the high level of bcl-2 content, one function ofwhich is the preclusion ofapoptosis. In preparations there is revealed a significant gain in the number of bcl-2 expressing neurons, however, the protective effect of the protein is not fully realized, that leads to the significantly increase in the content of damaged hyperchromatic cells. The evaluation of results of the immunohistochemical study of the nervous tissue of albino rats according to data concerning the proteins caspase-3 and bcl-2 expression permits to make a conclusion about the capability of nanoargentum encapsulated into polymer matrix by passing the blood-brain barrier to induce the triggering apoptosis cascade in neurons of the cerebral cortex.
[Mh] Termos MeSH primário: Encéfalo
Galactanos/farmacologia
Larix
Nanopartículas Metálicas/efeitos adversos
Prata
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Biopolímeros/farmacologia
Barreira Hematoencefálica/metabolismo
Encéfalo/efeitos dos fármacos
Encéfalo/patologia
Encéfalo/fisiopatologia
Caspase 3/metabolismo
Imuno-Histoquímica
Modelos Animais
Preparações de Plantas/farmacologia
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Ratos
Prata/efeitos adversos
Prata/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biopolymers); 0 (Galactans); 0 (Plant Preparations); 0 (Proto-Oncogene Proteins c-bcl-2); 3M4G523W1G (Silver); EC 3.4.22.- (Caspase 3); SL4SX1O487 (arabinogalactan)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:27774794
[Au] Autor:Seay JS; Mandigo M; Kish J; Menard J; Marsh S; Kobetz E
[Ad] Endereço:a Miller School of Medicine , University of Miami , Miami , FL , USA.
[Ti] Título:Intravaginal practices are associated with greater odds of high-risk HPV infection in Haitian women.
[So] Source:Ethn Health;22(3):257-265, 2017 Jun.
[Is] ISSN:1465-3419
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Haitian women have the highest incidence of cervical cancer within the Western hemisphere. Intravaginal hygiene practices have been linked with human papilloma virus (HPV) infection and cervical dysplasia. These practices, known as 'twalet deba' in Haitian Creole, are common among Haitian women and are performed with various natural and synthetic agents. As part of a community-based participatory research initiative aimed at reducing cervical cancer disparities in rural Haiti, we explored the use of intravaginal agents and their associations with high-risk HPV infection. DESIGN: Community Health Workers recruited 416 women for cervical self-sampling from two neighborhoods within Thomonde, Haiti. Participants were interviewed regarding intravaginal hygiene practices and completed a cervical self-sampling procedure. Cervical samples were analyzed for the presence of high-risk HPV infection. Associations between each intravaginal agent and high-risk HPV infection were examined via univariate logistic regression analyses, as well as via multivariate analyses controlling for sociodemographic factors and concurrent agent use. RESULTS: Nearly all women (97.1%) performed twalet deba, using a variety of herbal and commercially produced intravaginal agents. Approximately 11% of the participants tested positive for high-risk HPV. Pigeon pea and lime juice were the only agents found to be associated with high-risk HPV in the univariate analyses, with women who used these agents being approximately twice as likely to have high-risk HPV as those who did not. Only pigeon pea remained significantly associated with high-risk HPV after controlling for sociodemographic factors and concurrent agent use. CONCLUSION: Two agents, pigeon pea and lime juice, may contribute to risk for HPV infection in this population. Results suggest that in addition to cervical cancer screening interventions, future preventive initiatives should focus on minimizing risk by advocating for the use of less-toxic twalet deba alternatives.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde/etnologia
Higiene
Infecções por Papillomavirus/etnologia
Ducha Vaginal/efeitos adversos
[Mh] Termos MeSH secundário: Administração Intravaginal
Adulto
Compostos de Alúmen/administração & dosagem
Cajanus
Citrus aurantiifolia
Pesquisa Participativa Baseada na Comunidade
Feminino
Sucos de Frutas e Vegetais
Haiti/epidemiologia
Seres Humanos
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Preparações de Plantas/administração & dosagem
Permanganato de Potássio/administração & dosagem
Fatores de Risco
Sabões/administração & dosagem
Ducha Vaginal/métodos
Saúde da Mulher/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alum Compounds); 0 (Plant Preparations); 0 (Soaps); 00OT1QX5U4 (Potassium Permanganate); 34S289N54E (aluminum sulfate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1080/13557858.2016.1246423


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[PMID]:29268027
[Au] Autor:Gouws C; Hamman JH
[Ad] Endereço:a Pharmacen™, Centre of Excellence for Pharmaceutical Sciences , North-West University , Potchefstroom , South Africa.
[Ti] Título:Recent developments in our understanding of the implications of traditional African medicine on drug metabolism.
[So] Source:Expert Opin Drug Metab Toxicol;14(2):161-168, 2018 Feb.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The use of traditional herbal medicines has become increasingly popular globally, but in some countries, it is the main or sometimes even the only healthcare service available in the most rural areas. This is especially true for Africa where herbal medicines form a key component of traditional medicinal practices and there is access to a diversity of medicinal plants. Although many benefits have been derived from the use of traditional herbal medicines, many concerns are associated with their use of which herb-drug interactions have been identified to have a rising impact on patient treatment outcome. One type of pharmacokinetic interaction involves the modulation of drug metabolizing enzymes, which may result in enhanced or reduced bioavailability of co-administered drugs. Areas covered: This review highlights the current information available on drug metabolism-associated information with regards to traditional African medicines related to some of the most prevalent diseases burdening the African continent. Expert opinion: It is clear from previous studies that enzyme modulation by traditional African medicines plays a significant role in the pharmacokinetics of some co-administered drugs, but more research is needed to provide detailed information on these interactions, specifically for treatment of prevalent diseases such as tuberculosis and hypertension.
[Mh] Termos MeSH primário: Interações Ervas-Drogas
Preparações de Plantas/administração & dosagem
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Seres Humanos
Medicina Tradicional Africana/métodos
Preparações Farmacêuticas/metabolismo
Preparações de Plantas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Plant Preparations)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2018.1421171


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[PMID]:29107877
[Au] Autor:Lin S; Yang H; Na Z; Lin K
[Ad] Endereço:State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: linsen@ecust.edu.cn.
[Ti] Título:A novel biodegradable arsenic adsorbent by immobilization of iron oxyhydroxide (FeOOH) on the root powder of long-root Eichhornia crassipes.
[So] Source:Chemosphere;192:258-266, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, FeOOH was immobilized on the biodegradable root powder, abbreviated as RP, of long-root Eichhornia crassipes, a kind of waste biomass, to improve the adsorption performances for aqueous arsenic contaminants. The adsorption kinetics and thermodynamics experiments showed that the adsorption rates and capacities of the root powder for arsenate (As(V)) and arsenite (As(III)) were both enhanced markedly after modification with FeOOH. The adsorption of As(V) and As(III) by the modified root powder, abbreviated as MRP, could arrive at equilibrium in 50 min and the saturated adsorption capacities reached up to 8.67-9.43 mg/g for As(V) and 5.21-5.65 mg/g for As(V) at temperature of 10-50 °C, respectively. Besides, the effect of pH and ionic strength on adsorption was investigated and the results showed that the optimum pH for the arsenic adsorption using the MRP was 9.0 and the As(V) adsorption was more sensitive to ionic strength. Furthermore, the complexation of hydratable hydroxyls on FeOOH with arsenic contaminants was concluded as the adsorption force according FTIR and XPS analyses. The MRP used could be regenerated via 0.4 mol/L NaOH solution and no apparent adsorption capacity losses appeared after 6 cyclic utilizations.
[Mh] Termos MeSH primário: Arsenicais/metabolismo
Eichhornia/metabolismo
Preparações de Plantas/metabolismo
Poluentes Químicos da Água/metabolismo
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Arseniatos/metabolismo
Arsênico/metabolismo
Arsenitos/metabolismo
Compostos Férricos/metabolismo
Concentração de Íons de Hidrogênio
Concentração Osmolar
Raízes de Plantas/metabolismo
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Ferric Compounds); 0 (Plant Preparations); 0 (Water Pollutants, Chemical); 2UA751211N (ferric hydroxide); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE


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[PMID]:29258490
[Au] Autor:Bailon-Moscoso N; Tinitana F; Martínez-Espinosa R; Jaramillo-Velez A; Palacio-Arpi A; Aguilar-Hernandez J; Romero-Benavides JC
[Ad] Endereço:Departamento de Ciencias de la Salud, Universidad Técnica Particular de Loja, Loja, Ecuador. ncbailon@utpl.edu.ec.
[Ti] Título:Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador.
[So] Source:BMC Complement Altern Med;17(1):539, 2017 Dec 19.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: "Horchata" is an herbal mixture infusion consumed in Southern Ecuador; 66% of its plants are anti-inflammatory medicinal plant, and 51% are analgesics. Anti-inflammatory substances can prevent carcinogenesis mediated by cytotoxic effects and can prevent DNA damage. The aim of this study was to evaluate the cytotoxicity and apoptotic/antigenotoxic effects of horchata as well as its mechanism. METHODS: Nine different varieties of horchata were prepared in the traditional way and then freeze-dried. Phytochemical screening tested for the presence of secondary metabolites using standard procedures and antioxidant activities. The cytotoxic activity was evaluated on cerebral astrocytoma (D-384), prostate cancer (PC-3), breast cancer (MCF-7), colon cancer (RKO), lung cancer (A-549), immortalized Chinese hamster ovary cells (CHO-K1), and human peripheral blood lymphocytes via a MTS assay. The pro-apoptotic effects were evaluated with Anexin V/Propidium Iodide and western blot of Bax, Bcl-2, TP53, and TP73. Induction and reduction of ROS were assessed by fluorimetry. Genotoxic and antigenotoxic effects were evaluated with a comet assay and micronuclei on binucleated cells. RESULTS: Five of nine horchatas had cytotoxic effects against D-384 while not affecting normal cells. These horchatas induce cell death by apoptosis modulated by p53/p73. In CHO-K1 cells, the horchatas decrease the damage induced by hydrogen peroxide and Mitomycin C measured in the comet and micronucleus assay respectively. CONCLUSIONS: The IC range of effective horchatas in D-384 was 41 to 122 µg·mL . This effect may be related to its use in traditional medicine (brain tonic). On the other hand, immortalized Chinese hamster ovary cells (CHO-K1) and lymphocytes did not show a cytotoxic effect. The most potent horchata induced apoptosis via a p53/p73-mediated mechanism. The horchatas present antigenotoxic properties, which may be related to the antioxidant capacity. Future studies on horchata components are necessary to understand the interactions and beneficial properties.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Bebidas
Sobrevivência Celular/efeitos dos fármacos
Dano ao DNA/efeitos dos fármacos
Preparações de Plantas/farmacologia
Plantas Medicinais
[Mh] Termos MeSH secundário: Animais
Células CHO
Linhagem Celular
Ensaio Cometa
Cricetinae
Cricetulus
Equador
Linfócitos/efeitos dos fármacos
Medicina Tradicional
Testes para Micronúcleos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Preparations)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2048-x


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[PMID]:29258482
[Au] Autor:Oh SM; Park G; Lee SH; Seo CS; Shin HK; Oh DS
[Ad] Endereço:The K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.
[Ti] Título:Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposure times.
[So] Source:BMC Complement Altern Med;17(1):544, 2017 Dec 19.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acute kidney injury (AKI) is an initial factor in many kidney disorders. Pre- and intra-renal AKI biomarkers have recently been reported. Recovery from AKI by herbal medicine has rarely been reported. Thus, this study aimed to investigate the dose- and time-dependent effects of herbal medicines to protect against AKI in cisplatin-induced human kidney 2 (HK-2) cells by assessing the activities of high-mobility group box protein 1 (HMGB1), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). METHODS: Proximal tubular HK-2 cell lines were treated with either 400 µM of cisplatin for 6 h or 10 µM of cisplatin for 24 h and then exposed to ten types of single herbal medicines, including Nelumbo nymphaea (NY) at a dose of 100 µg/mL. The AKI biomarkers HMGB1, NGAL and KIM-1 were repeatedly measured by an ELISA assay at 2, 4, and 6 h in the group treated with 400 µM of cisplatin to confirm necrotic cell death and at 6, 24, and 48 h in the group treated with 10 µM of cisplatin to examine apoptotic cell death. Recovery confirm was conducted through in vivo study using ICR mice for 3 day NY or Paeonia suffruticosa intake. RESULTS: Cisplatin treatment at a concentration of 10 µM decreased cell viability. Treatment with 400 µM of cisplatin reduced HMBG1 activity and resulted in lactate dehydrogenase release. In longer exposure durations (up to 48 h), NGAL and KIM-1 exhibited activity from 24 h onward. Additionally, NY treatment resulted in an approximately 50% change in all three biomarkers. The time-dependent profiles of HMGB1, NGAL and KIM-1 activities up to 48 h were notably different; HMGB1 exhibited a 7-fold change at 6 h, and NGAL and KIM-1 exhibited 1.7-fold changes at 24 h, respectively. Consistently, serum and urine NGAL and KIM-1 activities were all reduced in ICR mice. CONCLUSIONS: Several single herbal medicines, including NY, have a potential as effectors of AKI due to their ability to inhibit the activation of HMGB1, NGAL and KIM-1 in an in vitro AKI-mimicked condition and simple in vivo confirm. Furthermore, an in vivo proof-of-concept study is needed.
[Mh] Termos MeSH primário: Lesão Renal Aguda/tratamento farmacológico
Preparações de Plantas/farmacologia
Preparações de Plantas/uso terapêutico
Substâncias Protetoras/farmacologia
Substâncias Protetoras/uso terapêutico
[Mh] Termos MeSH secundário: Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/fisiopatologia
Animais
Morte Celular/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Cisplatino/efeitos adversos
Proteína HMGB1/metabolismo
Receptor Celular 1 do Vírus da Hepatite A/metabolismo
Seres Humanos
Lipocalina-2/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos ICR
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HAVCR1 protein, human); 0 (HMGB1 Protein); 0 (Hepatitis A Virus Cellular Receptor 1); 0 (Lipocalin-2); 0 (Plant Preparations); 0 (Protective Agents); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2055-y


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[PMID]:29277760
[Au] Autor:Glei M; Fischer S; Lamberty J; Ludwig D; Lorkowski S; Schlörmann W
[Ad] Endereço:Friedrich Schiller University Jena, Institute of Nutrition, Department of Nutritional Toxicology, Jena, Germany.
[Ti] Título:Chemopreventive Potential of Fermented Raw and Roasted Hazelnuts in LT97 Colon Adenoma Cells.
[So] Source:Anticancer Res;38(1):83-93, 2018 01.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS: Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180.4°C/21 min) on chemopreventive effects of in vitro fermented hazelnuts was analyzed in LT97 colon adenoma cells. RESULTS: FS (2.5%) of raw and roasted hazelnuts reduced H O -induced DNA damage while 5% FS significantly induced gene expression of SOD2 (3.0-fold) and GSTP1 (2.1-fold). GPx1 mRNA levels were significantly decreased (0.6-fold) by FS (2.5%). The growth of LT97 cells was significantly reduced by hazelnut FS in a time- and dose-dependent manner. Hazelnut FS (5%) increased the numbers of early apoptotic cells (9.6% on average) and caspase-3 activities (6.4-fold on average). CONCLUSION: These results indicate a chemopreventive potential of in vitro fermented hazelnuts which is largely unaffected by the roasting process.
[Mh] Termos MeSH primário: Adenoma/tratamento farmacológico
Anticarcinógenos/farmacologia
Antineoplásicos/farmacologia
Neoplasias do Colo/tratamento farmacológico
Corylus
Preparações de Plantas/farmacologia
[Mh] Termos MeSH secundário: Adenoma/genética
Adenoma/prevenção & controle
Apoptose/efeitos dos fármacos
Catalase/genética
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Neoplasias do Colo/genética
Neoplasias do Colo/prevenção & controle
Culinária
Dano ao DNA/efeitos dos fármacos
Glutationa Peroxidase/genética
Glutationa S-Transferase pi/genética
Seres Humanos
Peróxido de Hidrogênio/toxicidade
Nozes
RNA Mensageiro/metabolismo
Superóxido Dismutase-1/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 0 (Antineoplastic Agents); 0 (Plant Preparations); 0 (RNA, Messenger); 0 (SOD1 protein, human); BBX060AN9V (Hydrogen Peroxide); EC 1.11.1.- (glutathione peroxidase GPX1); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase-1); EC 2.5.1.18 (GSTP1 protein, human); EC 2.5.1.18 (Glutathione S-Transferase pi)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:29241288
[Au] Autor:Steflitsch W
[Ti] Título:[Aromatherapy - From Traditional and Scientific Evidence into Clinical Practice].
[Ti] Título:Aromatherapie: wann können ätherische Öle medizinisch eingesetzt werden?.
[So] Source:Dtsch Med Wochenschr;142(25):1936-1942, 2017 Dec.
[Is] ISSN:1439-4413
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Essential oils (EOs), also known as volatile oils, are concentrated natural plant products which contain volatile aroma compounds. Most EOs are derived by steam distillation, a tradition which can be traced back as many as 5000 years. They possess unique properties which result in various possibilities for application, also in modern medical contexts. Areas for medical aromatherapy include respiratory diseases, pain management or stress alleviation, amongst many others. Different modes of application exist: The rich ingredients can be absorbed by the body by anointment, gentle massage, inhalation, or oral intake of capsules. Also the risks of EO application in medical contexts should be considered, such as rare allergic reactions, overdosing, poor substance quality or overestimation of the effectiveness.
[Mh] Termos MeSH primário: Aromaterapia
[Mh] Termos MeSH secundário: Aromaterapia/história
Aromaterapia/métodos
Aromaterapia/utilização
História do Século XXI
História Antiga
Seres Humanos
Medicina Tradicional
Manejo da Dor/métodos
Preparações de Plantas/uso terapêutico
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-116476


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[PMID]:29178904
[Au] Autor:Arentz S; Smith CA; Abbott J; Bensoussan A
[Ad] Endereço:National Institute of Complementary Medicine, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia. s.arentz@westernsydney.edu.au.
[Ti] Título:Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis.
[So] Source:BMC Complement Altern Med;17(1):500, 2017 Nov 25.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Polycystic ovary syndrome (PCOS) is a common, reproductive endocrinopathy associated with serious short and long term health risks. Many women with PCOS use ingestible complementary medicines. This systematic review examined the effect on menstrual regulation and adverse effects from randomised controlled trials. METHODS: Randomised controlled trials (RCTs) that compared herbal or nutritional supplements to placebo or active controls in women with PCOS were eligible for inclusion. Electronic databases were searched to July 2017. Study selection and assessment of quality were conducted independently by two review authors. RESULTS: Twenty four studies (1406 women) investigating seven nutritional supplements and four herbal medicines were included. No one study was assessed as having a low risk of bias. Four trials reported on the primary endpoint menstrual regulation. There was no evidence on improved menstrual regularity for calcium plus vitamin D compared to Metformin (RR: 0.66, 95% CI 0.35 to 1.23, p = 0.19), reduced amenorrhoea for Camellia sinensis compared to placebo (RR: 0.17, 95% CI 0.02 to 1.72, p = 0.13) and no difference in the number of menses per month for Cinnamomum sp. against placebo (MD 0.05, 95% CI -0.36 to 1.36, p = 0.26). Adverse effects were investigated in seven studies (164 women). Mild adverse effects were found for Cinnamomum sp. compared to placebo (17 women, RR: 0.36, 95% CI 0.03 to 0.70, p = 0.03). No difference was found for adverse effects between inositol, B complex vitamins, vitamin D, chromium and placebo. Improved reproduction, metabolic hormones and hyperandrogenism was found for inositol and improved cholesterol for omega three fish oils. CONCLUSION: There is no high quality evidence to support the effectiveness of nutritional supplements and herbal medicine for women with PCOS and evidence of safety is lacking. High quality trials of nutritional supplements and herbal medicines examining menstrual regulation and adverse effects in women with PCOS are needed.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Fitoterapia
Preparações de Plantas/uso terapêutico
Síndrome do Ovário Policístico/tratamento farmacológico
Vitaminas/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Plant Preparations); 0 (Vitamins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2011-x


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[PMID]:28452059
[Au] Autor:Jafari SM; Ganje M; Dehnad D; Ghanbari V; Hajitabar J
[Ad] Endereço:Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
[Ti] Título:Arrhenius equation modeling for the shelf life prediction of tomato paste containing a natural preservative.
[So] Source:J Sci Food Agric;97(15):5216-5222, 2017 Dec.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The shelf life of tomato paste with microencapsulated olive leaf extract was compared with that of samples containing a commercial preservative by accelerated shelf life testing. Based on previous studies showing that olive leaf extract as a rich source of phenolic compounds can have antimicrobial properties, application of its encapsulated form to improve the storage stability of tomato paste is proposed here. RESULTS: Regarding total soluble solids, the control and the sample containing 1000 µg g sodium benzoate had the lowest (Q = 1.63) and highest (Q = 1.88) sensitivity to temperature changes respectively; also, the microencapsulated sample containing 1000 µg g encapsulated olive leaf extract (Q = 1.83) followed the sample containing 1000 µg g sodium benzoate in terms of the highest kinetic rates. In the case of consistency, the lowest and highest activation energies (E ) corresponded to samples containing 1000 µg g non-encapsulated olive leaf extract and 1000 µg g microencapsulated olive leaf extract respectively. CONCLUSION: Interestingly, samples containing microencapsulated olive leaf extract could maintain the original quality of the tomato paste very well, while those with non-encapsulated olive leaf extract rated the worst performance (among all specimens) in terms of maintaining their quality indices for a long time period. Overall, the shelf life equation was able to predict the consistency index of all tomato paste samples during long-time storage with high precision. © 2017 Society of Chemical Industry.
[Mh] Termos MeSH primário: Conservantes de Alimentos/análise
Lycopersicon esculentum/química
Olea/química
Preparações de Plantas/química
[Mh] Termos MeSH secundário: Antioxidantes/análise
Conservação de Alimentos
Armazenamento de Alimentos
Modelos Biológicos
Extratos Vegetais/análise
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Food Preservatives); 0 (Plant Extracts); 0 (Plant Preparations)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.8404



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