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[PMID]:26818254
[Au] Autor:Wollman LB; Haggerty J; Pilarski JQ; Levine RB; Fregosi RF
[Ad] Endereço:Department of Physiology, The University of Arizona, Tucson, Arizona, 85724.
[Ti] Título:Developmental nicotine exposure alters cholinergic control of respiratory frequency in neonatal rats.
[So] Source:Dev Neurobiol;76(10):1138-49, 2016 10.
[Is] ISSN:1932-846X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prenatal nicotine exposure with continued exposure through breast milk over the first week of life (developmental nicotine exposure, DNE) alters the development of brainstem circuits that control breathing. Here, we test the hypothesis that DNE alters the respiratory motor response to endogenous and exogenous acetylcholine (ACh) in neonatal rats. We used the brainstem-spinal cord preparation in the split-bath configuration, and applied drugs to the brainstem compartment while measuring the burst frequency and amplitude of the fourth cervical ventral nerve roots (C4VR), which contain the axons of phrenic motoneurons. We applied ACh alone; the nicotinic acetylcholine receptor (nAChR) antagonist curare, either alone or in the presence of ACh; and the muscarinic acetylcholine receptor (mAChR) antagonist atropine, either alone or in the presence of ACh. The main findings include: (1) atropine reduced frequency similarly in controls and DNE animals, while curare caused modest slowing in controls but no consistent change in DNE animals; (2) DNE greatly attenuated the increase in C4VR frequency mediated by exogenous ACh; (3) stimulation of nAChRs with ACh in the presence of atropine increased frequency markedly in controls, but not DNE animals; (4) stimulation of mAChRs with ACh in the presence of curare caused a modest increase in frequency, with no treatment group differences. DNE blunts the response of the respiratory central pattern generator to exogenous ACh, consistent with reduced availability of functionally competent nAChRs; DNE did not alter the muscarinic control of respiratory motor output. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1138-1149, 2016.
[Mh] Termos MeSH primário: Acetilcolina/metabolismo
Nicotina/toxicidade
Agonistas Nicotínicos/toxicidade
Efeitos Tardios da Exposição Pré-Natal
Respiração
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Animais
Animais Recém-Nascidos
Atropina/farmacologia
Tronco Encefálico/efeitos dos fármacos
Tronco Encefálico/crescimento & desenvolvimento
Tronco Encefálico/metabolismo
Agonistas Colinérgicos/farmacologia
Curare/farmacologia
Modelos Animais de Doenças
Feminino
Potenciais da Membrana/efeitos dos fármacos
Potenciais da Membrana/fisiologia
Neurônios Motores/efeitos dos fármacos
Neurônios Motores/metabolismo
Antagonistas Muscarínicos/farmacologia
Antagonistas Nicotínicos/farmacologia
Nervo Frênico/efeitos dos fármacos
Nervo Frênico/crescimento & desenvolvimento
Nervo Frênico/metabolismo
Gravidez
Ratos Sprague-Dawley
Respiração/efeitos dos fármacos
Medula Espinal/efeitos dos fármacos
Medula Espinal/crescimento & desenvolvimento
Medula Espinal/metabolismo
Técnicas de Cultura de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Cholinergic Agonists); 0 (Muscarinic Antagonists); 0 (Nicotinic Agonists); 0 (Nicotinic Antagonists); 6M3C89ZY6R (Nicotine); 7C0697DR9I (Atropine); 8063-06-7 (Curare); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160129
[St] Status:MEDLINE
[do] DOI:10.1002/dneu.22380


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[PMID]:26657094
[Au] Autor:Valero MD; Hancock KE; Liberman MC
[Ad] Endereço:Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA; Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Michelle_Valero@meei.harvard.edu.
[Ti] Título:The middle ear muscle reflex in the diagnosis of cochlear neuropathy.
[So] Source:Hear Res;332:29-38, 2016 Feb.
[Is] ISSN:1878-5891
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cochlear neuropathy, i.e. the loss of auditory nerve fibers (ANFs) without loss of hair cells, may cause hearing deficits without affecting threshold sensitivity, particularly if the subset of ANFs with high thresholds and low spontaneous rates (SRs) is preferentially lost, as appears to be the case in both aging and noise-damaged cochleas. Because low-SR fibers may also be important drivers of the medial olivocochlear reflex (MOCR) and middle-ear muscle reflex (MEMR), these reflexes might be sensitive metrics of cochlear neuropathy. To test this hypothesis, we measured reflex strength and reflex threshold in mice with noise-induced neuropathy, as documented by confocal analysis of immunostained cochlear whole-mounts. To assay the MOCR, we measured contra-noise modulation of ipsilateral distortion-product otoacoustic emissions (DPOAEs) before and after the administration of curare to block the MEMR or curare + strychnine to also block the MOCR. The modulation of DPOAEs was 1) dominated by the MEMR in anesthetized mice, with a smaller contribution from the MOCR, and 2) significantly attenuated in neuropathic mice, but only when the MEMR was intact. We then measured MEMR growth functions by monitoring contra-noise induced changes in the wideband reflectance of chirps presented to the ipsilateral ear. We found 1) that the changes in wideband reflectance were mediated by the MEMR alone, and 2) that MEMR threshold was elevated and its maximum amplitude was attenuated in neuropathic mice. These data suggest that the MEMR may be valuable in the early detection of cochlear neuropathy.
[Mh] Termos MeSH primário: Nervo Coclear/fisiopatologia
Orelha Média/inervação
Perda Auditiva Provocada por Ruído/diagnóstico
Músculo Esquelético/inervação
Reflexo
Doenças do Nervo Vestibulococlear/diagnóstico
[Mh] Termos MeSH secundário: Estimulação Acústica
Animais
Audiometria
Fadiga Auditiva
Limiar Auditivo
Nervo Coclear/efeitos dos fármacos
Curare/administração & dosagem
Modelos Animais de Doenças
Diagnóstico Precoce
Perda Auditiva Provocada por Ruído/etiologia
Perda Auditiva Provocada por Ruído/fisiopatologia
Masculino
Camundongos Endogâmicos CBA
Fármacos Neuromusculares não Despolarizantes/administração & dosagem
Ruído/efeitos adversos
Emissões Otoacústicas Espontâneas
Valor Preditivo dos Testes
Reflexo/efeitos dos fármacos
Estricnina/administração & dosagem
Transmissão Sináptica
Doenças do Nervo Vestibulococlear/etiologia
Doenças do Nervo Vestibulococlear/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Neuromuscular Nondepolarizing Agents); 8063-06-7 (Curare); H9Y79VD43J (Strychnine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE


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[PMID]:26496427
[Au] Autor:Malca Garcia GR; Hennig L; Shelukhina IV; Kudryavtsev DS; Bussmann RW; Tsetlin VI; Giannis A
[Ad] Endereço:Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig , Johannisallee 29, 04103 Leipzig, Germany.
[Ti] Título:Curare Alkaloids: Constituents of a Matis Dart Poison.
[So] Source:J Nat Prod;78(11):2537-44, 2015 Nov 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of D-(-)-quinic acid, L-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. D-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Curare/isolamento & purificação
Tubocurarina/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides/farmacologia
Animais
Curare/química
Estrutura Molecular
Oócitos/efeitos dos fármacos
Venenos/farmacologia
Ratos
Tubocurarina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Poisons); 8063-06-7 (Curare); W9YXS298BM (Tubocurarine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151125
[Lr] Data última revisão:
151125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151027
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b00457


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[PMID]:26134652
[Au] Autor:Zachary SP; Fuchs PA
[Ad] Endereço:Solomon H. Snyder Department of Neuroscience, Centers for Sensory Biology and Hearing and Balance, Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
[Ti] Título:Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss.
[So] Source:J Neurosci;35(26):9701-6, 2015 Jul 01.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Hearing loss among the elderly correlates with diminished social, mental, and physical health. Age-related cochlear cell death does occur, but growing anatomical evidence suggests that synaptic rearrangements on sensory hair cells also contribute to auditory functional decline. Here we present voltage-clamp recordings from inner hair cells of the C57BL/6J mouse model of age-related hearing loss, which reveal that cholinergic synaptic inputs re-emerge during aging. These efferents are functionally inhibitory, using the same ionic mechanisms as do efferent contacts present transiently before the developmental onset of hearing. The strength of efferent inhibition of inner hair cells increases with hearing threshold elevation. These data indicate that the aged cochlea regains features of the developing cochlea and that efferent inhibition of the primary receptors of the auditory system re-emerges with hearing impairment. SIGNIFICANCE STATEMENT: Synaptic changes in the auditory periphery are increasingly recognized as important factors in hearing loss. To date, anatomical work has described the loss of afferent contacts from cochlear hair cells. However, relatively little is known about the efferent innervation of the cochlea during hearing loss. We performed intracellular recordings from mouse inner hair cells across the lifespan and show that efferent innervation of inner hair cells arises in parallel with the loss of afferent contacts and elevated hearing threshold during aging. These efferent neurons inhibit inner hair cells, raising the possibility that they play a role in the progression of age-related hearing loss.
[Mh] Termos MeSH primário: Cóclea/patologia
Células Ciliadas Auditivas Internas/fisiologia
Perda Auditiva/patologia
Inibição Neural/fisiologia
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Fatores Etários
Animais
Animais Recém-Nascidos
Apamina/farmacologia
Bloqueadores dos Canais de Cálcio/farmacologia
Conotoxinas/farmacologia
Curare/farmacologia
Proteínas de Ligação a DNA/metabolismo
Modelos Animais de Doenças
Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos
Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia
Feminino
Glicinérgicos/farmacologia
Perda Auditiva/fisiopatologia
Camundongos
Camundongos Endogâmicos C57BL
Fármacos Neuromusculares não Despolarizantes/farmacologia
Fosfoproteínas/metabolismo
Estricnina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (ACV1, Conus textile); 0 (Calcium Channel Blockers); 0 (Conotoxins); 0 (Ctbp2 protein, mouse); 0 (DNA-Binding Proteins); 0 (Glycine Agents); 0 (Neuromuscular Nondepolarizing Agents); 0 (Phosphoproteins); 24345-16-2 (Apamin); 8063-06-7 (Curare); H9Y79VD43J (Strychnine); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150703
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0879-15.2015


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[PMID]:25614180
[Au] Autor:Pagán OR; Montgomery E; Deats S; Bach D; Baker D
[Ad] Endereço:Department of Biology, West Chester University, West Chester, PA, 19383, USA. opagan@wcupa.edu.
[Ti] Título:Evidence of Nicotine-Induced, Curare-Insensitive, Behavior in Planarians.
[So] Source:Neurochem Res;40(10):2087-90, 2015 Oct.
[Is] ISSN:1573-6903
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and curare (1 mM), while curare alone does not induce significant pSLMs. The simplest interpretation of our data is that there are nicotine induced behaviors insensitive to curare in our experimental organism. To the best of our knowledge, this is the first report on curare-insensitive, nicotine-induced effects in any organism.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Curare/farmacologia
Movimento/efeitos dos fármacos
Nicotina/farmacologia
Planárias/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Planárias/metabolismo
Convulsões/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
6M3C89ZY6R (Nicotine); 8063-06-7 (Curare)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150124
[St] Status:MEDLINE
[do] DOI:10.1007/s11064-015-1512-6


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[PMID]:25409503
[Au] Autor:Carl J; Schwarzer M; Klingelhoefer D; Ohlendorf D; Groneberg DA
[Ad] Endereço:Institute for Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, Frankfurt, Germany.
[Ti] Título:Curare--a curative poison: a scientometric analysis.
[So] Source:PLoS One;9(11):e112026, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Curare is one of the best-examined neurotoxins of the world, which has empirically been used for centuries by American Indigenes. Research on curare has been performed much later, a global scientometric analysis on curare research or its derivates does not yet exist. This bibliometric analysis is part of the global NewQis-project and should illuminate both toxic and historic issues of research on curare. METHODS: The ISI Web of Science was searched for data covering 1900 to 2013 using a term which included as many original articles on curare as possible. 3,867 articles were found and analyzed for common bibliometric items such as the number of citations, language of the articles or the (modified) Hirsch-Index (h-index). Results are illustrated utilizing modern density equalizing map projections (DEMP) or beam diagrams. RESULTS: Most publications were located in North America and Europe. The USA has the highest number of publications as well as the highest h-index. The number of publications overall rose until the late 1990s and later decreased. Furthermore, sudden increases of research activity are ascribable to historic events, like the first use of curare as muscle relaxant during surgery. DISCUSSION: This scientometric analysis of curare research reflects several tendencies as previously seen in other bibliometric investigations, i.e. the scientific quality standard of North America and Europe. Research on curare decreased however, due to the declining attention towards this muscle relaxant. This work exemplifies also how scientometric methods can be used to illuminate historic circumstances immediately stimulating scientific research.
[Mh] Termos MeSH primário: Bibliometria
Pesquisa Biomédica/tendências
Curare/uso terapêutico
[Mh] Termos MeSH secundário: Bases de Dados Bibliográficas/tendências
Europa (Continente)
Seres Humanos
América do Norte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
8063-06-7 (Curare)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0112026


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[PMID]:24981230
[Au] Autor:Beurg M; Kim KX; Fettiplace R
[Ad] Endereço:Department of Neuroscience, University of Wisconsin Medical School, Madison, WI 53706.
[Ti] Título:Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.
[So] Source:J Gen Physiol;144(1):55-69, 2014 Jul.
[Is] ISSN:1540-7748
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transmembrane channel-like (TMC) proteins TMC1 and TMC2 are crucial to the function of the mechanotransducer (MT) channel of inner ear hair cells, but their precise function has been controversial. To provide more insight, we characterized single MT channels in cochlear hair cells from wild-type mice and mice with mutations in Tmc1, Tmc2, or both. Channels were recorded in whole-cell mode after tip link destruction with BAPTA or after attenuating the MT current with GsMTx-4, a peptide toxin we found to block the channels with high affinity. In both cases, the MT channels in outer hair cells (OHCs) of wild-type mice displayed a tonotopic gradient in conductance, with channels from the cochlear base having a conductance (110 pS) nearly twice that of those at the apex (62 pS). This gradient was absent, with channels at both cochlear locations having similar small conductances, with two different Tmc1 mutations. The conductance of MT channels in inner hair cells was invariant with cochlear location but, as in OHCs, was reduced in either Tmc1 mutant. The gradient of OHC conductance also disappeared in Tmc1/Tmc2 double mutants, in which a mechanically sensitive current could be activated by anomalous negative displacements of the hair bundle. This "reversed stimulus-polarity" current was seen with two different Tmc1/Tmc2 double mutants, and with Tmc1/Tmc2/Tmc3 triple mutants, and had a pharmacological sensitivity comparable to that of native MT currents for most antagonists, except dihydrostreptomycin, for which the affinity was less, and for curare, which exhibited incomplete block. The existence in the Tmc1/Tmc2 double mutants of MT channels with most properties resembling those of wild-type channels indicates that proteins other than TMCs must be part of the channel pore. We suggest that an external vestibule of the MT channel may partly account for the channel's large unitary conductance, high Ca(2+) permeability, and pharmacological profile, and that this vestibule is disrupted in Tmc mutants.
[Mh] Termos MeSH primário: Células Ciliadas Auditivas/fisiologia
Mecanotransdução Celular/fisiologia
Proteínas de Membrana/antagonistas & inibidores
Proteínas de Membrana/fisiologia
Mutação/genética
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Cóclea/citologia
Cóclea/efeitos dos fármacos
Cóclea/fisiologia
Curare/farmacologia
Relação Dose-Resposta a Droga
Células Ciliadas Auditivas/efeitos dos fármacos
Mecanotransdução Celular/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos CBA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (TMC1 protein, mouse); 8063-06-7 (Curare)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140702
[St] Status:MEDLINE
[do] DOI:10.1085/jgp.201411173


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[PMID]:24677157
[Au] Autor:Pías-Peleteiro JM; Aldrey JM; Martinón-Torres M; Sier MJ
[Ad] Endereço:Hospital Clinico de Santiago de Compostela, 15706 Santiago de Compostela, Espana.
[Ti] Título:[Flax-leaved daphne (Daphne gnidium L.): an ancient European timbo].
[Ti] Título:El torvisco (Daphne gnidium L.): un timbó ancestral europeo..
[So] Source:Rev Neurol;58(7):335-6, 2014 Apr 01.
[Is] ISSN:1576-6578
[Cp] País de publicação:Spain
[La] Idioma:spa
[Mh] Termos MeSH primário: Curare
Índios Sul-Americanos
Plantas Tóxicas
Venenos
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:COMMENT; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Poisons); 8063-06-7 (Curare)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:140328
[Lr] Data última revisão:
140328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140329
[St] Status:MEDLINE


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[PMID]:23760418
[Au] Autor:Maurya SK; Periasamy M; Bal NC
[Ad] Endereço:Davis Heart and Lung Research Institute, Columbus, OH, USA.
[Ti] Título:High gender -specific susceptibility to curare- a neuromuscular blocking agent.
[So] Source:Biol Res;46(1):75-8, 2013.
[Is] ISSN:0717-6287
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Curare, a selective skeletal muscle relaxant, has been used clinically to reduce shivering and as an anesthetic auxiliary in abdominal surgery. It is also widely used in animal experiments to block neuromuscular junction activity. Effective doses of curare diminish muscle contraction without affecting brain function, but at higher doses it is known to be lethal. However, the exact dose of curare initiating muscle relaxation vs. lethal effect has not been fully characterized in mice. In this study we carefully examined the dose-response for achieving muscle inactivity over lethality in both male and female mice (C57BL6/J). The most striking finding of this study is that female mice were highly susceptible to curare; both the ED50 and LD50 were at least 3-fold lower than male littermates. This study shows that gender-specific differences can be an important factor when administering skeletal muscle relaxants, particularly curare or other analogous agents targeted to the neuromuscular junction.
[Mh] Termos MeSH primário: Curare/administração & dosagem
Fármacos Neuromusculares não Despolarizantes/administração & dosagem
Consumo de Oxigênio/efeitos dos fármacos
Fatores Sexuais
[Mh] Termos MeSH secundário: Animais
Metabolismo Basal/efeitos dos fármacos
Temperatura Corporal/efeitos dos fármacos
Ritmo Circadiano/efeitos dos fármacos
Curare/toxicidade
Relação Dose-Resposta a Droga
Comportamento Alimentar/efeitos dos fármacos
Feminino
Imobilização
Estimativa de Kaplan-Meier
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Fármacos Neuromusculares não Despolarizantes/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Neuromuscular Nondepolarizing Agents); 8063-06-7 (Curare)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130614
[St] Status:MEDLINE


  10 / 960 MEDLINE  
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[PMID]:23521313
[Au] Autor:Brown TC
[Ad] Endereço:Royal Childrens Hospital, Melbourne, Vic., Australia. tckbrown@netspace.net.au
[Ti] Título:From arrow poison to neuromuscular blockers.
[So] Source:Paediatr Anaesth;23(9):865-7, 2013 Sep.
[Is] ISSN:1460-9592
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Bloqueadores Neuromusculares/história
Venenos/história
[Mh] Termos MeSH secundário: Animais
Curare/história
Equidae
História do Século XVI
História do Século XIX
Seres Humanos
Fármacos Neuromusculares não Despolarizantes/história
Paralisia/induzido quimicamente
Tubocurarina/história
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Waterton Charles C
[Nm] Nome de substância:
0 (Neuromuscular Blocking Agents); 0 (Neuromuscular Nondepolarizing Agents); 0 (Poisons); 8063-06-7 (Curare); W9YXS298BM (Tubocurarine)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:130809
[Lr] Data última revisão:
130809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130326
[St] Status:MEDLINE
[do] DOI:10.1111/pan.12152



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