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[PMID]:28877280
[Au] Autor:Epasinghe DJ; Yiu CKY; Burrow MF
[Ad] Endereço:Prince Philip Dental Hospital, University of Hong Kong, Faculty of Dentistry, Hong Kong SAR, China.
[Ti] Título:Mechanical properties, water sorption characteristics, and compound release of grape seed extract-incorporated resins.
[So] Source:J Appl Oral Sci;25(4):412-419, 2017 Jul-Aug.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: This study evaluated the effect of grape seed extract (GSE) incorporation on the mechanical properties, water sorption, solubility, and GSE release from the experimental adhesive resins. Material and Methods: An experimental comonomer mixture, consisting of 40% Bis-GMA, 30% Bis MP, 28% HEMA, 0.26% camphorquinone and 1% EDMAB, was used to prepare four GSE-incorporated adhesive resins at concentrations of 0.5, 1, 1.5, and 2 wt%. The neat resin without GSE was used as the control. Six resin beams (25 mm x 2 mm x 2 mm) per group were prepared for flexural strength and modulus of elasticity evaluations using a universal testing machine at a crosshead speed of 1 mm/min. Five disks (6 mm in diameter and 2 mm in thickness) per group were used for microhardness measurements using a Leitz micro-hardness tester with Leica Qgo software. Five disks (7 mm in diameter and 2 mm in thickness) per group were prepared and stored in deionized water for 28 days. Water sorption, solubility, and GSE release in deionized water were calculated for each GSE-incorporated adhesive at the end of 28th day. Data was evaluated using one-way ANOVA and Tukey multiple comparisons. Results: Flexural strength, modulus of elasticity and microhardness of GSE-incorporated adhesive decreased significantly with incorporation of 1.5% of GSE (p<0.05). Addition of GSE had no effect on the water sorption of the adhesive resins (p=0.33). The solubility of the resin also increased significantly with incorporation of 1.5% of GSE (p<0.05). Quantities of GSE release increased with increased concentration of GSE in the adhesive resin. Conclusion: Up to 1% of GSE can be incorporated into a dental adhesive resin without interfering with the mechanical properties or solubility of the resins.
[Mh] Termos MeSH primário: Bis-Fenol A-Glicidil Metacrilato/química
Cânfora/análogos & derivados
Extrato de Sementes de Uva/química
Metacrilatos/química
Cimentos de Resina/química
para-Aminobenzoatos/química
[Mh] Termos MeSH secundário: Análise de Variância
Cânfora/química
Módulo de Elasticidade
Testes de Dureza
Teste de Materiais
Maleabilidade
Proantocianidinas/química
Valores de Referência
Reprodutibilidade dos Testes
Solubilidade
Estatísticas não Paramétricas
Fatores de Tempo
Água/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Grape Seed Extract); 0 (Methacrylates); 0 (Proanthocyanidins); 0 (Resin Cements); 0 (ethyl 4-N,N-dimethylaminobenzoate); 0 (para-Aminobenzoates); 059QF0KO0R (Water); 18206-61-6 (proanthocyanidin); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate); 6E1I4IV47V (hydroxyethyl methacrylate); 76-22-2 (Camphor); RAL3591W33 (camphorquinone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  2 / 573 MEDLINE  
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[PMID]:28780322
[Au] Autor:Niu L; Shao M; Liu Y; Hu J; Li R; Xie H; Zhou L; Shi L; Zhang R; Niu Y
[Ad] Endereço:Department of Toxicology, Hebei Medical University, Shijiazhuang, China; Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011 Hebei, China.
[Ti] Título:Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice.
[So] Source:Chem Biol Interact;275:133-144, 2017 Sep 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Titanium dioxide nanoparticles (TiO NPs) are widely used to additives in cosmetics, pharmaceuticals, paints and foods. Recent studies have demonstrated that TiO NPs increased the risk of cancer and the mechanism might relate with oxidative stress. Grape seed procyanidin extract (GSPE) is a natural compound which has been demonstrated to possess a wide array of pharmacological and biochemical actions, including anti-inflammatory, anti-carcinogenic, and antioxidant properties. Our data show that GSPE prevents the changes of histopathology and biomarkers in heart, liver and kidney that occur in mice exposed to TiO NPs. After pretreatment with GSPE, the DNA damage, reactive oxygen species (ROS) generation and malondialdehyde (MDA) content in mice exposed to TiO NPs had statistically significant decreases in dose dependent manners. GSPE increased the expression of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), NAD(P)H dehydrogenase[quinine] 1(NQO1), heme oxygenase 1 (HO-1) and glutamate-cysteine ligase catalytic subunit (GCLC). We conclude that grape seed procyanidin extract prevents the majority of tissue and molecular damage resulting from nanoparticle treatment. The protective effect of GSPE may be due to its strong antioxidative activities which related with the activated Nrf2 and its down-regulated genes including NQO1, HO-1 and GCLC.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Extrato de Sementes de Uva
Nanopartículas Metálicas/toxicidade
Fator 2 Relacionado a NF-E2/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Titânio/química
[Mh] Termos MeSH secundário: Animais
Biflavonoides/química
Biflavonoides/isolamento & purificação
Biflavonoides/farmacologia
Catequina/química
Catequina/isolamento & purificação
Catequina/farmacologia
Dano ao DNA/efeitos dos fármacos
Regulação para Baixo/efeitos dos fármacos
Glutamato-Cisteína Ligase/metabolismo
Extrato de Sementes de Uva/química
Heme Oxigenase-1/metabolismo
Rim/efeitos dos fármacos
Rim/metabolismo
Rim/patologia
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Malondialdeído/metabolismo
Nanopartículas Metálicas/química
Camundongos
NAD(P)H Desidrogenase (Quinona)/metabolismo
Proantocianidinas/química
Proantocianidinas/isolamento & purificação
Proantocianidinas/farmacologia
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biflavonoids); 0 (Grape Seed Extract); 0 (NF-E2-Related Factor 2); 0 (Proanthocyanidins); 0 (Reactive Oxygen Species); 15FIX9V2JP (titanium dioxide); 4852-22-6 (procyanidin); 4Y8F71G49Q (Malondialdehyde); 8R1V1STN48 (Catechin); D1JT611TNE (Titanium); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone)); EC 1.6.5.2 (Nqo1 protein, mouse); EC 6.3.2.2 (Glutamate-Cysteine Ligase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


  3 / 573 MEDLINE  
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[PMID]:28756814
[Au] Autor:Wang C; Li J; Song GL; Niu Q; Xu SZ; Feng GL; Wang HX; Li Y; Li SG; Li F
[Ad] Endereço:Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi 832002, Xinjiang, China.
[Ti] Título:Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice.
[So] Source:Biomed Environ Sci;30(7):535-539, 2017 Jul.
[Is] ISSN:0895-3988
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of the present study is to evaluate the ability and mechanism by which grape seed procyanidin extract (GSPE) relieves arsenic trioxide (As2O3)-induced renal inflammatory injury. Therefore, male Kunming mice were treated with As2O3 and/or GSPE by gavage for 5 weeks. Mice were then sacrificed and inflammatory cytokines of kidneys were examined by ELISA, whereas the expression levels of molecules involved in the nuclear factor (NF)-κB signaling pathway were evaluated by both qRT-PCR and Western blot. Our results indicate that GSPE prevents As2O3-mediated renal inflammatory injury by inhibiting activation of the NF-κB signaling pathway and inflammatory cytokine production, while promoting expression of anti-inflammatory cytokines.
[Mh] Termos MeSH primário: Arsênico/toxicidade
Extrato de Sementes de Uva/uso terapêutico
Inflamação/induzido quimicamente
Nefropatias/induzido quimicamente
Proantocianidinas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Inflamação/tratamento farmacológico
Nefropatias/tratamento farmacológico
Masculino
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Grape Seed Extract); 0 (Grape Seed Proanthocyanidins); 0 (Proanthocyanidins); N712M78A8G (Arsenic)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.3967/bes2017.071


  4 / 573 MEDLINE  
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[PMID]:28697472
[Au] Autor:Che DN; Xie GH; Cho BO; Shin JY; Kang HJ; Jang SI
[Ad] Endereço:Department of Health Care & Science, Jeonju University, Jeonju 55069, Republic of Korea.
[Ti] Título:Protective effects of grape stem extract against UVB-induced damage in C57BL mice skin.
[So] Source:J Photochem Photobiol B;173:551-559, 2017 Aug.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Humans have become exposed to another form of a trait which is ultraviolet B (UVB) radiation reaching the earth's surface. This has become a major source of oxidative stress that ultimately leads to inflammation, DNA damage, photoaging and pigmentation disorders etc. Although several studies have shown the photo-protective role of different grape parts like the fruits and seeds, little or no data demonstrating the in vivo photo-protective role of grape stem, which is the most discarded part of the grape are available. We evaluated the protective influence of grape stem extract against UVB-induced oxidative damage in C57BL mice characterized by epidermal hyperplasia, pigmentation, collagen degradation and inflammation. Grape stem extract was administered topically 1week before UVB irradiation (120mJ/cm ) and continued until the termination of the experiment. A group of non-irradiated mice and a group of irradiated mice topically administered with propylene were used as a negative and positive control. Epidermal thickness, pigmentation, erythema, mast cell and neutrophil infiltration, collagen degradation and COX-2, Nrf2, and HO-1 expressions were evaluated. Grape stem extract markedly recovered skin damage induced by the UVB radiation through the prevention of epidermal hyperplasia, pigmentation, erythema, mast cell and neutrophil infiltrations, collagen degradation and COX-2, Nrf2, and HO-1 expressions. Our study demonstrated for the first time in C57BL mice that grape stem extract reduces UVB-induced oxidative damage and hence can play a protective role in skin photo-damage.
[Mh] Termos MeSH primário: Extrato de Sementes de Uva/farmacologia
Substâncias Protetoras/farmacologia
Pele/efeitos dos fármacos
Raios Ultravioleta
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Colágeno/genética
Colágeno/metabolismo
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/metabolismo
Eritema/patologia
Expressão Gênica/efeitos dos fármacos
Expressão Gênica/efeitos da radiação
Glutationa/análise
Heme Oxigenase-1/genética
Heme Oxigenase-1/metabolismo
Masculino
Malondialdeído/análise
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Extratos Vegetais/análise
Extratos Vegetais/química
Pele/efeitos da radiação
Pigmentação da Pele/efeitos dos fármacos
Pigmentação da Pele/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Grape Seed Extract); 0 (Membrane Proteins); 0 (Plant Extracts); 0 (Protective Agents); 4Y8F71G49Q (Malondialdehyde); 9007-34-5 (Collagen); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE


  5 / 573 MEDLINE  
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[PMID]:28693689
[Au] Autor:Kong X; Guan J; Gong S; Wang R
[Ad] Endereço:Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China;Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, Massachusetts 02114, USA.
[Ti] Título:Neuroprotective Effects of Grape Seed Procyanidin Extract on Ischemia-Reperfusion Brain Injury.
[So] Source:Chin Med Sci J;32(2):92-9, 2017 Jun 10.
[Is] ISSN:1001-9294
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Objective Oxidative stress (OS) plays a crucial role in ischemic stroke. Grape seed procyanidin extract (GSPE) was reported to be a critical regulator of OS. We hypothesized that GSPE might also be protective in ischemia-reperfusion brain injury. This study aimed to explore whether GSPE administration can protect mice from ischemia-reperfusion brain injury.Methods Transient middle cerebral artery occlusion (MCAO) was conducted followed by reperfusion for 24 hours to make ischemia-reperfusion brain injury in mice that received GSPE (MCAOG, n=60) or normal saline (MCAONS, n=60). Sham-operated mice (GSPE group and normal saline group) were set as controls. The neurological severity score (NSS) was used to evaluate neural function impairment 1 hour, 24 hour, 3 days and 7 days after MCAO. Mice underwent brain T2WI imaging with a 3T animal MRI scanner 24 hours after reperfusion, and the stroke volume of brains were calculated according to abnormal signal intensity. Immunohistopathological analysis of brain tissues at 24 h after reperfusion was performed for neuronal nuclear antigen (NeuN), CD34, Bcl-2, and Bax. Glutathione peroxidation (GSH-Px) activity and the level of malonaldehyde (MDA) of brain tissue were also examined. The above indexes were compared among the groups statistically.Results Significant functional improvement was observed 24 hours after MCAO in MCAOG group compared to MCAONS group (P<0.05). MCAOG group had smaller cerebral stroke volume (22.46 ± 11.45 mm vs. 47.84±9.06 mm , P<0.05) than MCAONS group 24 hours after MCAO. More mature NeuN-immunoreactive neurons and more CD34-positive cells in peri-infarct zones were observed in brain tissue of MCAOG mice 24 h after MCAO than that of MCAONS mice (both P<0.05). MCAONS mice had significantly higher number of Bax-positive cells in brain tissue than MCAOG (P<0.05). The mean MDA level was significantly lower (P<0.05) and the GSH-Px activity was significantly higher (P<0.05) in brains of MCAOG mice compared to those of MCAONS mice.Conclusion GSPE administration protects mice from ischemia-reperfusion brain injury through attenuating oxidative stress and apoptosis, promoting angiogenesis, and activating antioxidant enzyme GSH-Px. GSPE may represent a new therapeutical direction for the treatment of ischemia-reperfusion brain injury.
[Mh] Termos MeSH primário: Encéfalo/irrigação sanguínea
Extrato de Sementes de Uva/farmacologia
Fármacos Neuroprotetores/farmacologia
Proantocianidinas/farmacologia
Traumatismo por Reperfusão/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Glutationa Peroxidase/metabolismo
Infarto da Artéria Cerebral Média
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Estresse Oxidativo
Traumatismo por Reperfusão/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Grape Seed Extract); 0 (Grape Seed Proanthocyanidins); 0 (Neuroprotective Agents); 0 (Proanthocyanidins); EC 1.11.1.9 (Glutathione Peroxidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.24920/J1001-9294.2017.020


  6 / 573 MEDLINE  
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[PMID]:28502165
[Au] Autor:Lee JW; Kim YI; Im CN; Kim SW; Kim SJ; Min S; Joo YH; Yim SV; Chung N
[Ad] Endereço:College of Life Sciences & Biotechnology, Korea University , Seoul, 02841, Republic of Korea.
[Ti] Título:Grape Seed Proanthocyanidin Inhibits Mucin Synthesis and Viral Replication by Suppression of AP-1 and NF-κB via p38 MAPKs/JNK Signaling Pathways in Respiratory Syncytial Virus-Infected A549 Cells.
[So] Source:J Agric Food Chem;65(22):4472-4483, 2017 Jun 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Airway epithelial cells are often infected by respiratory syncytial virus (RSV), one of the most common causes of asthma, bronchiolitis, chronic obstructive pulmonary disease, and pneumonia. During the infection process, excessive mucins instigate airway inflammation. However, the mechanism underlying RSV-induced airway hyper-responsiveness and inflammation is poorly understood. Furthermore, no reliable vaccines or drugs for antiviral therapy are available. In this study, the effect of the natural compound grape seed proanthocyanidin (GSP) on RSV-infected human airway epithelial cells A549 was evaluated. After pretreatment of the cells with or without exposure to RSV with 5-10 µg GSP/mL, the expression of various mucins (MUC1, MUC2, MUC5AC, MUC5B, and MUC8) was evaluated by real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and Western blotting, as well as confocal microscopy. We found that GSP significantly decreased RSV-induced mucin synthesis at the mRNA and protein levels. In addition, GSP suppressed the RSV-induced signaling pathways, including extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38, together with nuclear factor kappa B (NF-κB) and activating protein-1 family members (c-Jun and c-Fos). Concomitantly, GSP inhibited the replication of RSV within A549 cells. Taken together, all our results suggest that GSP could be a potent therapeutic agent to suppress excessive mucus production and viral replication in RSV-induced airway inflammatory disorders.
[Mh] Termos MeSH primário: Extrato de Sementes de Uva/farmacologia
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Mucinas/biossíntese
Proantocianidinas/farmacologia
Infecções por Vírus Respiratório Sincicial/metabolismo
Vírus Sinciciais Respiratórios/efeitos dos fármacos
Vírus Sinciciais Respiratórios/fisiologia
[Mh] Termos MeSH secundário: Células A549
Seres Humanos
MAP Quinase Quinase 4/genética
MAP Quinase Quinase 4/metabolismo
NF-kappa B/genética
NF-kappa B/metabolismo
Infecções por Vírus Respiratório Sincicial/genética
Infecções por Vírus Respiratório Sincicial/virologia
Fator de Transcrição AP-1/genética
Fator de Transcrição AP-1/metabolismo
Replicação Viral
Proteínas Quinases p38 Ativadas por Mitógeno/genética
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Grape Seed Extract); 0 (Grape Seed Proanthocyanidins); 0 (Mucins); 0 (NF-kappa B); 0 (Proanthocyanidins); 0 (Transcription Factor AP-1); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 2.7.12.2 (MAP Kinase Kinase 4)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00923


  7 / 573 MEDLINE  
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[PMID]:28403352
[Au] Autor:Özden FO; Sakallioglu EE; Sakallioglu U; Ayas B; Erisgin Z
[Ad] Endereço:Ondokuz Mayis University, School of Dentistry, Department of Periodontology, Samsun, Turkey.
[Ti] Título:Effects of grape seed extract on periodontal disease: an experimental study in rats.
[So] Source:J Appl Oral Sci;25(2):121-129, 2017 Mar-Apr.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: This study aimed to demonstrate the effect of grape seed extract (GSE) on periodontitis. Material and Methods: Ligature induced periodontitis was created in 40 rats and they were assigned to four equal groups. One group was fed laboratory diet (group A) while three groups received GSE additionally. Silk ligatures were placed around the cervical area of the mandibular first molars for four weeks to induce periodontitis. The GSE groups were reallocated regarding GSE consumption as: for two weeks before ligation (group B; totally eight weeks), from ligation to two weeks after removal of the ligature (group C; totally six weeks), and for two weeks from ligature removal (group D; totally two weeks). Sections were assessed histologically and immunohistochemically. Inflammatory cell number (ICN), connective tissue attachment level (CAL), osteoclast density (OD), IL-10 and TGF-ß stainings in gingival epithelium (GE), connective tissue (GC), and periodontal ligament (PL) were used as the study parameters. Results: Lower ICN, higher CAL, and lower OD were observed in the GSE groups (p<0.05). IL-10 was more intensive in the GSE groups and in the GEs (p<0.05). Group B showed the highest IL-10 for PL (p<0.05). TGF-ß was higher in the GEs of all groups (p<0.017). Conclusions: The results suggest anti-inflammatory activities of GSE, but further investigations are needed for clarification of these activities.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Extrato de Sementes de Uva/farmacologia
Periodontite/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Gengiva/patologia
Extrato de Sementes de Uva/uso terapêutico
Imuno-Histoquímica
Interleucina-10/análise
Masculino
Periodontite/patologia
Distribuição Aleatória
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Fatores de Tempo
Fator de Crescimento Transformador beta/análise
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Grape Seed Extract); 0 (Transforming Growth Factor beta); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


  8 / 573 MEDLINE  
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[PMID]:28376889
[Au] Autor:Liu HJ; Pan XX; Liu BQ; Gui X; Hu L; Jiang CY; Han Y; Fan YX; Tang YL; Liu WT
[Ad] Endereço:Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, 211166, People's Republic of China.
[Ti] Título:Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression.
[So] Source:J Neuroinflammation;14(1):74, 2017 Apr 04.
[Is] ISSN:1742-2094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1ß production. Reactive oxygen species (ROS) promoted development of the inflammatory process through NLRP3 inflammasome. Our study aimed to find a food-derived compound to attenuate gout pain via the specific inhibition of the NLRP3 inflammasome in macrophages. METHODS: CD-1 mice were used to evaluate the degree of pain and the swelling dimension of joints after an intra-articular (IA) MSU injection in the ankle. The murine macrophage cell line Raw 264.7 was used to investigate the effects of procyanidins and the mechanism underlying such effects. Histological analysis was used to measure the infiltration of inflammatory cells. ROS produced from Raw 264.7 cells were evaluated by flow cytometry. Cell signaling was measured by Western blot assay and immunofluorescence. RESULTS: Procyanidins significantly attenuated gout pain and suppressed ankle swelling. Procyanidins also inhibited MSU-induced activation of the NLRP3 inflammasome and increase of IL-1ß. Furthermore, procyanidins decreased ROS levels in Raw 264.7 cells. CONCLUSIONS: Suppression of the NLRP3 inflammasome in macrophages contributes to the amelioration of gout pain by procyanidins.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antioxidantes/toxicidade
Extrato de Sementes de Uva/uso terapêutico
Inflamação/tratamento farmacológico
Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo
Dor/complicações
Proantocianidinas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Tornozelo/fisiopatologia
Colchicina/análogos & derivados
Colchicina/farmacologia
Citocinas/metabolismo
Gota/induzido quimicamente
Gota/complicações
Inflamação/induzido quimicamente
Inflamação/complicações
Lipopolissacarídeos/farmacologia
Camundongos
Dor/tratamento farmacológico
Dor/etiologia
Fosforilação/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
Medula Espinal/efeitos dos fármacos
Medula Espinal/metabolismo
Ácido Úrico/toxicidade
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cytokines); 0 (Grape Seed Extract); 0 (Lipopolysaccharides); 0 (NLR Family, Pyrin Domain-Containing 3 Protein); 0 (Nlrp3 protein, mouse); 0 (Proanthocyanidins); 0 (Reactive Oxygen Species); 268B43MJ25 (Uric Acid); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); HJ30158L57 (colchiceine); SML2Y3J35T (Colchicine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1186/s12974-017-0849-y


  9 / 573 MEDLINE  
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[PMID]:28315767
[Au] Autor:Shahbazi Y
[Ad] Endereço:Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. Electronic address: yasser.shahbazi@yahoo.com.
[Ti] Título:The properties of chitosan and gelatin films incorporated with ethanolic red grape seed extract and Ziziphora clinopodioides essential oil as biodegradable materials for active food packaging.
[So] Source:Int J Biol Macromol;99:746-753, 2017 Jun.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to improve different characteristics including antibacterial, antioxidant, physical and mechanical properties of chitosan (Ch) and gelatin (Ge) films by incorporating Ziziphora clinopodioides essential oil (ZEO; 0 and 1% v/w) and ethanolic grape seed extract (GSE; 0 and 1% v/w). The main compounds of the ZEO were carvacrol (65.22%) and thymol (19.51%). According to our findings, addition of aforementioned materials could improve total phenolic content, antibacterial and antioxidant activities, thickness and also water vapor barrier property. ZEO and GSE reduces swelling index, tensile strength, puncture force and puncture deformation of Ch and Ge films. Pure Ch and Ge films had slightly yellow and white appearances, respectively, while films incorporated with GSE in combination with ZEO had grey appearances. This study indicated the some benefits of addition of ZEO and GSE into Ch and Ge films and their potentials for application as biodegradable active packaging.
[Mh] Termos MeSH primário: Quitosana/química
Etanol/química
Embalagem de Alimentos/métodos
Gelatina/química
Extrato de Sementes de Uva/química
Lamiaceae/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/metabolismo
Antibacterianos/farmacologia
Antioxidantes/química
Antioxidantes/metabolismo
Antioxidantes/farmacologia
Cor
Extrato de Sementes de Uva/isolamento & purificação
Fenômenos Mecânicos
Permeabilidade
Fenóis/análise
Vapor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Grape Seed Extract); 0 (Oils, Volatile); 0 (Phenols); 0 (Steam); 0 (gelatin film); 3K9958V90M (Ethanol); 9000-70-8 (Gelatin); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170320
[St] Status:MEDLINE


  10 / 573 MEDLINE  
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[PMID]:28300665
[Au] Autor:Liu Q; Jiang JX; Liu YN; Ge LT; Guan Y; Zhao W; Jia YL; Dong XW; Sun Y; Xie QM
[Ad] Endereço:Medical College of Yangzhou University, 11 Huaihai Road, Yangzhou 225001, China.
[Ti] Título:Grape seed extract ameliorates bleomycin-induced mouse pulmonary fibrosis.
[So] Source:Toxicol Lett;273:1-9, 2017 May 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pulmonary fibrosis is common in a variety of inflammatory lung diseases, such as interstitial pneumonia, chronic obstructive pulmonary disease, and silicosis. There is currently no effective clinical drug treatment. It has been reported that grape seed extracts (GSE) has extensive pharmacological effects with minimal toxicity. Although it has been found that GSE can improve the lung collagen deposition and fibrosis pathology induced by bleomycin in rat, its effects on pulmonary function, inflammation, growth factors, matrix metalloproteinases and epithelial-mesenchymal transition remain to be researched. In the present study, we studied whether GSE provided protection against bleomycin (BLM)-induced mouse pulmonary fibrosis. ICR strain mice were treated with BLM in order to establish pulmonary fibrosis models. GSE was given daily via intragastric administration for three weeks starting at one day after intratracheal instillation. GSE at 50 or 100mg/kg significantly reduced BLM-induced inflammatory cells infiltration, proinflammatory factor protein expression, and hydroxyproline in lung tissues, and improved pulmonary function in mice. Additionally, treatment with GSE also significantly impaired BLM-induced increases in lung fibrotic marker expression (collagen type I alpha 1 and fibronectin 1) and decreases in an anti-fibrotic marker (E-cadherin). Further investigation indicated that the possible molecular targets of GSE are matrix metalloproteinases-9 (MMP-9) and TGF-ß1, given that treatment with GSE significantly prevented BLM-induced increases in MMP-9 and TGF-ß1 expression in the lungs. Together, these results suggest that supplementation with GSE may improve the quality of life of lung fibrosis patients by inhibiting MMP-9 and TGF-ß1 expression in the lungs.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antibióticos Antineoplásicos/toxicidade
Bleomicina/toxicidade
Extrato de Sementes de Uva/uso terapêutico
Pulmão/efeitos dos fármacos
Fibrose Pulmonar/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Líquido da Lavagem Broncoalveolar/química
Feminino
Extrato de Sementes de Uva/administração & dosagem
Pulmão/imunologia
Pulmão/patologia
Metaloproteinase 9 da Matriz/metabolismo
Camundongos Endogâmicos ICR
Fibrose Pulmonar/induzido quimicamente
Fibrose Pulmonar/imunologia
Fibrose Pulmonar/patologia
Testes de Função Respiratória
Fator de Crescimento Transformador beta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antibiotics, Antineoplastic); 0 (Grape Seed Extract); 0 (Transforming Growth Factor beta); 11056-06-7 (Bleomycin); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, mouse)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170704
[Lr] Data última revisão:
170704
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE



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