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[PMID]:28455458
[Au] Autor:Seyani C; Green P; Daniel L; Pegden A
[Ad] Endereço:Great Western Hospital, Swindon, UK.
[Ti] Título:An interesting case of opium tea toxicity.
[So] Source:BMJ Case Rep;2017, 2017 Apr 28.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We present an unusual cause of respiratory arrest resulting from sole ingestion of home-brewed opium tea. A 64-year-old woman was found unresponsive and in respiratory arrest by a first responder. There were no obvious signs of regular recreational drug use. On presentation to the local district general hospital, the patient was in extremis, with severe physiological and biochemical derangements. A naloxone infusion was commenced and she later made a good recovery. It was subsequently discovered that she had brewed opium tea from opium buds she had picked from a nearby commercial poppy farm, a practice she had learnt while in Afghanistan.
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Opioides/diagnóstico
Ópio/toxicidade
Chá/toxicidade
[Mh] Termos MeSH secundário: Administração Intravenosa
Afeganistão
Coma/diagnóstico
Coma/etiologia
Feminino
Seres Humanos
Meia-Idade
Naloxona/administração & dosagem
Naloxona/uso terapêutico
Antagonistas de Entorpecentes/administração & dosagem
Antagonistas de Entorpecentes/uso terapêutico
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Ópio/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Narcotic Antagonists); 0 (Tea); 36B82AMQ7N (Naloxone); 8008-60-4 (Opium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29235761
[Au] Autor:Sydor RI; Khranovska NM; Skachkova OV; Skivka LM
[Ti] Título:The effect of perioperative analgesic drugs omnopon and dexketoprofen on the functional activity of immune cells in murine model of tumor surgery.
[So] Source:Ukr Biochem J;88(4):40-7, 2016 Jul-Aug.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:We aimed to investigate the effect of perioperative analgesia with nonselective cyclooxygenase-2 inhibitor dexketoprofen and opioid drug omnopon on the functional activity of immune cells in tumor excision murine model. Lewis lung carcinoma cells were transplanted into hind paw of C57/black mice. On the 23th day tumor was removed. Analgesic drugs were injected 30 min before and once a day for 3 days after the surgery. Biological material was obtained a day before, 1 day and 3 days after the tumor removal. IFN-γ, IL-4, IL-10 and TGF-ß mRNA levels in splenic cells were assessed by quantitative real-time RT-PCR. Cytotoxic activity of splenocytes was estimated by flow cytometry. We found that in splenocytes of mice received opioid analgesia IL-10 mRNA level was increased 2.3 times on day one after the surgery compared to preoperative level (P < 0.05), while in dexketoprofen group this parameter did not change. IFN-γ gene expression level on day 3 after tumor removal was 40% higher in splenocytes of dexketoprofen treated mice as compared with omnopon treated animals (P < 0.05). Cytotoxic activity of splenocytes on day 3 postsurgery was (62.2 ± 2.4)% in dexketoprofen against (50.2 ± 3.3)% in omnopon group. In conclusion, perioperative analgesia with cyclooxygenase inhibitor dexketoprofen in contrast to opioid analgesia with omnopon preserves higher functional activity of murine immune cells in the experimental model of tumor surgery.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Carcinoma Pulmonar de Lewis/imunologia
Citotoxicidade Imunológica/efeitos dos fármacos
Cetoprofeno/farmacologia
Linfócitos/efeitos dos fármacos
Ópio/farmacologia
Dor Processual/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Carcinoma Pulmonar de Lewis/genética
Carcinoma Pulmonar de Lewis/patologia
Carcinoma Pulmonar de Lewis/cirurgia
Expressão Gênica
Membro Posterior
Interferon gama/genética
Interferon gama/imunologia
Interleucina-10/genética
Interleucina-10/imunologia
Interleucina-4/genética
Interleucina-4/imunologia
Cetoprofeno/análogos & derivados
Linfócitos/citologia
Linfócitos/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Transplante de Neoplasias
Dor Processual/imunologia
Dor Processual/fisiopatologia
Período Perioperatório
RNA Mensageiro/genética
RNA Mensageiro/imunologia
Baço/citologia
Baço/efeitos dos fármacos
Baço/imunologia
Fator de Crescimento Transformador beta/genética
Fator de Crescimento Transformador beta/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (IL10 protein, mouse); 0 (RNA, Messenger); 0 (Transforming Growth Factor beta); 130068-27-8 (Interleukin-10); 207137-56-2 (Interleukin-4); 8008-60-4 (Opium); 82115-62-6 (Interferon-gamma); 90Y4QC304K (Ketoprofen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.04.040


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[PMID]:29067412
[Ti] Título:Treatment of the Opium Neurosis: By Stephen Lett, M.D., Ont., Canada.
[So] Source:JAMA;318(16):1617, 2017 Oct 24.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Transtornos Relacionados ao Uso de Opioides/história
[Mh] Termos MeSH secundário: Canadá
História do Século XIX
Seres Humanos
Transtornos Relacionados ao Uso de Opioides/terapia
Ópio/história
Síndrome de Abstinência a Substâncias/história
[Pt] Tipo de publicação:CLASSICAL ARTICLE; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
8008-60-4 (Opium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10492


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[PMID]:28586371
[Au] Autor:Afshari M; Janbabaei G; Bahrami MA; Moosazadeh M
[Ad] Endereço:Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran.
[Ti] Título:Opium and bladder cancer: A systematic review and meta-analysis of the odds ratios for opium use and the risk of bladder cancer.
[So] Source:PLoS One;12(6):e0178527, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The association between opium use and bladder cancer has been investigated in many studies, with varying reporting results reported. This study aims to estimate the total odds ratio for the association between bladder cancer and opium consumption using meta-analysis. METHODS: The study was designed according to PRISMA guidelines. Two independent researchers searched for the relevant studies using PubMed, Web of Science, Scopus, OVID, Embase, and Google Scholar. After systematic screening of the studies identified during the first step, Cochrane risk of bias tool was determined for the selected studies. The case-control and the cohort studies were investigated to assess risk of bladder cancer due to opium use. In addition, the cross-sectional studies were analysed separately to assess frequency of opium consumption. These estimates were combined using the inverse variance method. Fixed or random effect models were applied to combine the point odds ratios. The heterogeneity between the primary results was assessed using the Cochran test and I-square index. The suspected factors for heterogeneity were investigated using meta-regression models. An Egger test was conducted to identify any probable publication bias. Forest plots illustrated the point and pooled estimates. All analyses were performed using Stata version 14 software and RevMan version 5.3. RESULTS: We included 17 primary studies (11 case-control, one cohort and five cross-sectional) in the final meta-analysis. The total odds ratios (95% confidence intervals) for developing bladder cancer by opium use alone, and concurrent use of opium and cigarettes were estimated as 3.85 (3.05-4.87) and 5.7 (1.9-16.3) respectively. The odds ratio (95% confidence interval) for opium use with or without cigarette smoking was estimated as 5.3 (3.6-7.7). CONCLUSION: This meta-analysis showed that opium use similar to cigarette smoking and maybe with similar mechanisms can be a risk factor for bladder cancer. It is therefore expected to be a risk factor for other cancers.
[Mh] Termos MeSH primário: Ópio/efeitos adversos
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
Neoplasias da Bexiga Urinária/epidemiologia
[Mh] Termos MeSH secundário: Estudos Transversais
Seres Humanos
Irã (Geográfico)/epidemiologia
Fatores de Risco
Fumar/efeitos adversos
Transtornos Relacionados ao Uso de Substâncias/fisiopatologia
Neoplasias da Bexiga Urinária/induzido quimicamente
Neoplasias da Bexiga Urinária/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
8008-60-4 (Opium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178527


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[PMID]:28412823
[Au] Autor:Fallahzadeh MA; Salehi A; Naghshvarian M; Fallahzadeh MH; Poustchi H; Sepanlou SG; Gandomkar A; Malekzadeh R
[Ad] Endereço:MPH Department, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Epidemiologic Study of Opium Use in Pars Cohort Study: A Study of 9000 Adults in a Rural Southern Area of Iran.
[So] Source:Arch Iran Med;20(4):205-210, 2017 Apr.
[Is] ISSN:1735-3947
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Opium is one of the most common substances used worldwide with variable epidemiologic features in different regions. This study was performed in southern Iran, to find the epidemiology of opium use and its association with different factors and diseases. METHODS: This cross-sectional study was performed on baseline data extracted from Pars Cohort Study performed in Valashahr, a rural area in southern Iran. For any subject, information was collected about demographic factors, some common diseases including heart disease, stroke and hypertension and the state of using opium, other substances and cigarettes. RESULTS: There were 4276 males and 4988 females, with a mean age of 52.6 ± 9.7 years of whom 8.4% reported opium use (17.3% of males and 0.7% of females). In men, the history of stroke and heart disease were significantly more common in opium users (12.6% vs. 8.8%, P = 0.001 and 2.8% vs. 1.5%, P = 0.01, respectively) while the history of hypertension was significantly more common in non-opium users (7.8% vs. 10.3%, P = 0.04). Younger age, male gender, being non-married and positive history of joint pain, cigarette smoking and alcohol consumption were the factors associated with opium use. CONCLUSION: Opium use is common in non-married men who have a positive history of cigarette smoking and alcohol consumption in the rural population of southern Iran. It is associated with increased risk of heart disease and stroke and decreased risk of hypertension in males. Global interventional and preventive measures are required to control this complicated social problem.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/epidemiologia
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Ópio
Fumar/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Coortes
Estudos Transversais
Estudos Epidemiológicos
Feminino
Seres Humanos
Irã (Geográfico)/epidemiologia
Modelos Logísticos
Masculino
Meia-Idade
Fatores de Risco
População Rural
Fatores Sexuais
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
8008-60-4 (Opium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:0172004/AIM.004


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[PMID]:28040448
[Au] Autor:Butler K; Yi J; Wasson M; Klauschie J; Ryan D; Hentz J; Cornella J; Magtibay P; Kho R
[Ad] Endereço:Department of Gynecologic Surgery, Mayo Clinic Arizona, Phoenix, AZ. Electronic address: butler.kristina@mayo.edu.
[Ti] Título:Randomized controlled trial of postoperative belladonna and opium rectal suppositories in vaginal surgery.
[So] Source:Am J Obstet Gynecol;216(5):491.e1-491.e6, 2017 May.
[Is] ISSN:1097-6868
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: After vaginal surgery, oral and parenteral narcotics are used commonly for pain relief, and their use may exacerbate the incidence of sedation, nausea, and vomiting, which ultimately delays convalescence. Previous studies have demonstrated that rectal analgesia after surgery results in lower pain scores and less intravenous morphine consumption. Belladonna and opium rectal suppositories may be used to relieve pain and minimize side effects; however, their efficacy has not been confirmed. OBJECTIVE: We aimed to evaluate the use of belladonna and opium suppositories for pain reduction in vaginal surgery. MATERIALS AND METHODS: A prospective, randomized, double-blind, placebo-controlled trial that used belladonna and opium suppositories after inpatient or outpatient vaginal surgery was conducted. Vaginal surgery was defined as (1) vaginal hysterectomy with uterosacral ligament suspension or (2) posthysterectomy prolapse repair that included uterosacral ligament suspension and/or colporrhaphy. Belladonna and opium 16A (16.2/60 mg) or placebo suppositories were administered rectally immediately after surgery and every 8 hours for a total of 3 doses. Patient-reported pain data were collected with the use of a visual analog scale (at 2, 4, 12, and 20 hours postoperatively. Opiate use was measured and converted into parenteral morphine equivalents. The primary outcome was pain, and secondary outcomes included pain medication, antiemetic medication, and a quality of recovery questionnaire. Adverse effects were surveyed at 24 hours and 7 days. Concomitant procedures for urinary incontinence or pelvic organ prolapse did not preclude enrollment. RESULTS: Ninety women were randomly assigned consecutively at a single institution under the care of a fellowship-trained surgeon group. Demographics did not differ among the groups with mean age of 55 years, procedure time of 97 minutes, and prolapse at 51%. Postoperative pain scores were equivalent among both groups at each time interval. The belladonna and opium group used a mean of 57 mg morphine compared with 66 mg for placebo (P=.43) in 24 hours. Patient satisfaction with recovery was similar (P=.59). Antiemetic and ketorolac use were comparable among groups. Subgroup analyses of patients with prolapse and patients <50 years old did not reveal differences in pain scores. The use of belladonna and opium suppositories was uncomplicated, and adverse effects, which included constipation and urinary retention, were similar among groups. CONCLUSION: Belladonna and opium suppositories are safe for use after vaginal surgery. Belladonna and opium suppositories did not reveal lower pain or substantially lower narcotic use. Further investigation may be warranted to identify a population that may benefit optimally from belladonna and opium use.
[Mh] Termos MeSH primário: Analgésicos Opioides/administração & dosagem
Atropa belladonna
Ópio/administração & dosagem
Dor Pós-Operatória/prevenção & controle
Extratos Vegetais/uso terapêutico
Vagina/cirurgia
[Mh] Termos MeSH secundário: Antieméticos/administração & dosagem
Método Duplo-Cego
Uso de Medicamentos/estatística & dados numéricos
Feminino
Seres Humanos
Histerectomia Vaginal
Meia-Idade
Morfina/administração & dosagem
Satisfação do Paciente
Prolapso de Órgão Pélvico/cirurgia
Fitoterapia
Período Pós-Operatório
Estudos Prospectivos
Supositórios
Escala Visual Analógica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Antiemetics); 0 (Plant Extracts); 0 (Suppositories); 76I7G6D29C (Morphine); 8008-60-4 (Opium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


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[PMID]:27769612
[Au] Autor:Davarani SS; Mirfazaelian H
[Ad] Endereço:Emergency Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:An Unusual Cause of Abdominal Pain.
[So] Source:J Emerg Med;52(3):e73, 2017 Mar.
[Is] ISSN:0736-4679
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Intoxicação por Chumbo/diagnóstico
Ópio/efeitos adversos
Manejo da Dor/normas
[Mh] Termos MeSH secundário: Dor Abdominal/tratamento farmacológico
Serviço Hospitalar de Emergência/organização & administração
Enema/métodos
Seres Humanos
Irã (Geográfico)
Intoxicação por Chumbo/tratamento farmacológico
Manejo da Dor/métodos
Cloreto de Sódio/farmacologia
Cloreto de Sódio/uso terapêutico
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
451W47IQ8X (Sodium Chloride); 8008-60-4 (Opium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:26593749
[Au] Autor:Casale JF; Casale ES; Toske SG; Hays PA; Panicker S
[Ad] Endereço:Special Testing and Research Laboratory, U.S. Drug Enforcement Administration, 22624 Dulles Summit Court, Dulles, VA, 20166-9509, USA.
[Ti] Título:Characterization and origin of the 'B' and 'C' compounds in the acid/neutral forensic signatures of heroin - products from the acylation of porphyroxine and subsequent hydrolysis.
[So] Source:Drug Test Anal;9(3):462-469, 2017 Mar.
[Is] ISSN:1942-7611
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two significant compounds often found in the gas chromatographic analysis of the acid/neutral extracts from illicit heroin have remained uncharacterized for 30 years. The unknown compounds are referred to as the 'B' and 'C' compounds. It has been postulated that these compounds arise from acetylation of porphyroxine, a rhoeadine alkaloid found at trace levels in the opium poppy, Papaver somniferum. Porphyroxine was isolated from opium and acetylated to produce N,O -diacetylporphyroxine. Mild hydrolysis produced N,O -diacetyl-O -desmethyl-epi-porphyroxine (the C compound) and N-acetyl-O -desmethyl-epi-porphyroxine (the B compound). Both N,O -diacetyl-O -desmethyl-epi-porphyroxine and N-acetyl-O -desmethyl-epi-porphyroxine were determined to be C-14 epimers of porphyroxine and N,O -diacetylporphyroxine. The non-epimerized isomers of the B and C compounds were also detected in illicit heroin, but at much lower levels. Chromatographic and spectroscopic data are presented for the aforementioned compounds. The presence/absence and relative concentrations of these compounds is presented for the four types of heroin (Southwest Asian, South American, Southeast Asian, and Mexican). The prevalence of detection for the B and C compounds are Southwest Asian = 92-93%, South American = 64-72%, Southeast Asian = 45-49%, and Mexican ≤ 3%. When detected, the overall trend of relative concentrations of dicaetylporhyroxine, the B-compound, and C-compound is Southwest Asian > South American > Southeast Asian, each by an order of magnitude. These compounds were rarely detected in Mexican heroin. The presence/absence and relative concentrations of these compounds provide pertinent forensic signature characteristics that significantly enhance the final regional classifications. Copyright © 2015 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Alcaloides/química
Analgésicos Opioides/química
Heroína/química
Ópio/química
Drogas Ilícitas/química
[Mh] Termos MeSH secundário: Acilação
Alcaloides/isolamento & purificação
Cromatografia Gasosa-Espectrometria de Massas
Hidrólise
Isomerismo
Papaver/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Analgesics, Opioid); 0 (Street Drugs); 70D95007SX (Heroin); 8008-60-4 (Opium); 9Q9C65WH3B (rhoeadine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE
[do] DOI:10.1002/dta.1922


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[PMID]:28120592
[Au] Autor:Amin-Esmaeili M; Rahimi-Movaghar A; Gholamrezaei M; Razaghi EM
[Ad] Endereço:Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:Profile of People Who Inject Drugs in Tehran, Iran.
[So] Source:Acta Med Iran;54(12):793-805, 2016 Dec.
[Is] ISSN:1735-9694
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:The marked shift in the patterns of drug use in Iran, from opium smoking to injecting drug use, has led to serious health-related outcomes. This study was designed to explore characteristics of people who inject drugs (PWID) in Tehran, Iran. Nine hundred and four PWID were recruited from treatment and harm reduction facilities, as well as drug user hangouts in public areas in Tehran. Participants were interviewed using the Persian version of the World Health Organization Drug Injecting Study Phase II questionnaire. The median age at the time of the first illegal drug use, at the time of the first injection and current age was 20, 24 and 32, respectively. In more than 80% of the cases, the first drug used was opium. The transition from the first drug use to the first drug injection occurred after an average of 6.6 and 2.7 years for those who had started drug use with opium and heroin, respectively. Two-thirds of the participants shared injecting equipment within the last 6 months. Difficulty in obtaining sterile needles and thehigh cost of syringes were reported as the major reasons for needle/syringe sharing. Approximately 80% of community-recruited PWID reported difficulties in using treatment or harm reduction services. Self-detoxification and forced detoxification were the most common types of drug abuse treatment in alifetime. Despite a dramatic shift in drug policy in Iran during the past few years, wider coverage of harm reduction services, improvement of the quality of services, and education about such services are still necessary.
[Mh] Termos MeSH primário: Usuários de Drogas/estatística & dados numéricos
Transtornos Relacionados ao Uso de Opioides/epidemiologia
Abuso de Substâncias por Via Intravenosa/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Redução do Dano
Heroína
Seres Humanos
Irã (Geográfico)/epidemiologia
Masculino
Uso Comum de Agulhas e Seringas/estatística & dados numéricos
Ópio
Assunção de Riscos
Fumar
Inquéritos e Questionários
Organização Mundial da Saúde
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
70D95007SX (Heroin); 8008-60-4 (Opium)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE


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[PMID]:27803011
[Au] Autor:Azizi A; Ferguson K; Dluzewski S; Hussain T; Klein M
[Ad] Endereço:Barnet Hospital, Royal Free London NHS Foundation Trust, London, UK.
[Ti] Título:Chronic lead poisoning in an Iranian opium smoker resident in London.
[So] Source:BMJ Case Rep;2016, 2016 Nov 01.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 46-year-old man of Iranian origin presented with a 4-day history of colicky abdominal pain and absolute constipation on a background of several weeks of irritability and malaise. He had smoked 10 g of opium per week for a year and a half. On examination, he had diffuse abdominal tenderness and faecal loading. This was cleared, but the abdominal pain, nausea and vomiting persisted. He had extravascular haemolytic anaemia with punctate basophilic stippling on blood film. The patient's serum lead concentration was substantially elevated and he perhaps demonstrated Burton's line. The patient underwent chelation therapy and has recovered clinically and biochemically. Public health experts were notified and conducted an assessment of the risk to the patient and others; their lead exposure questionnaire was subsequently amended. This is an important case report of a UK resident describing lead toxicity secondary to the inhalation of opium.
[Mh] Termos MeSH primário: Intoxicação por Chumbo/etiologia
Transtornos Relacionados ao Uso de Opioides/complicações
Ópio/efeitos adversos
[Mh] Termos MeSH secundário: Quelantes/uso terapêutico
Terapia por Quelação
Doença Crônica
Contaminação de Medicamentos
Seres Humanos
Intoxicação por Chumbo/sangue
Intoxicação por Chumbo/diagnóstico
Masculino
Meia-Idade
Transtornos Relacionados ao Uso de Opioides/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 8008-60-4 (Opium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE



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