Base de dados : MEDLINE
Pesquisa : D20.215.894.818 [Categoria DeCS]
Referências encontradas : 301 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 31 ir para página                         

  1 / 301 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27771114
[Au] Autor:Joonè CJ; Schulman ML; Bertschinger HJ
[Ad] Endereço:Section of Reproduction, Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa; School of Veterinary Sciences, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia. Electronic address: carolynne.joone@jcu.edu.au.
[Ti] Título:Ovarian dysfunction associated with zona pellucida-based immunocontraceptive vaccines.
[So] Source:Theriogenology;89:329-337, 2017 Feb.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite more than 40 years of research into zona pellucida (ZP)-based vaccines, relatively little is known about their mechanism of action. Early research demonstrated precipitation of ZP glycoproteins by antiovarian antiserum, rendering oocytes resistant to sperm binding in vitro. Subsequent work showed significantly decreased fertilization rates following passive immunization, sparking interest in anti-ZP immunocontraception for human and animal use. The primary mechanism of action of ZP vaccines is generally considered to be an antibody-mediated interference with sperm-oocyte binding and/or fertilization. However, this mechanism of action excludes the potential for ovarian dysfunction associated with anti-ZP treatment in some species. A review of relevant literature in pertinent model, domestic and wildlife species reveals a variety of previous and current hypotheses for ovarian effects following ZP-based immunization. Ovarian dysfunction has been suggested to be a species-specific response. In addition, cytotoxic T-lymphocytes and the use of Freund's adjuvants have been suggested to play a role. Finally, the type and extent of glycosylation of ZP antigens have been proposed to influence ovarian effects. The validity of these hypotheses is re-examined in the light of current knowledge. Further investigation of ovarian function in species believed to be resistant to the ovarian effects of anti-ZP vaccines is warranted. To this end, anti-Müllerian hormone may provide a novel tool for the assessment of ovarian function during ZP-based immunocontraception, particularly in wildlife species not amenable to frequent clinical examination.
[Mh] Termos MeSH primário: Ooforite/induzido quimicamente
Ovário/efeitos dos fármacos
Vacinas Anticoncepcionais/efeitos adversos
Zona Pelúcida/imunologia
[Mh] Termos MeSH secundário: Animais
Feminino
Adjuvante de Freund/efeitos adversos
Mamíferos/imunologia
Mamíferos/fisiologia
Especificidade da Espécie
Linfócitos T Citotóxicos/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Vaccines, Contraceptive); 9007-81-2 (Freund's Adjuvant)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171203
[Lr] Data última revisão:
171203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 301 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28410124
[Au] Autor:Gupta SK; Minhas V
[Ad] Endereço:Reproductive Cell Biology Lab, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi-110067, India, skgupta@nii.ac.in.
[Ti] Título:Wildlife population management: are contraceptive vaccines a feasible proposition?
[So] Source:Front Biosci (Schol Ed);9:357-374, 2017 Jun 01.
[Is] ISSN:1945-0524
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To minimize human-animal conflicts for habitation and burden of zoonotic diseases, it is imperative to develop new strategies for wildlife population management. In this direction, contraceptive vaccines eliciting immune response against hormones/proteins critical for reproduction have emerged as one of the promising options. Contraceptive vaccines based on neutralization of gonadotropin releasing hormone (GnRH) have been used for inhibition of fertility in various species such as wild horses, white-tailed deer, pigs, cats, dogs etc. It has been used for immunocastration of male pigs to improve meat quality. However, additional safety studies of GnRH vaccine will be needed in light of presence of its receptor at extra-pituitary sites. Native porcine zona pellucida (PZP)-based contraceptive vaccines have shown their utility in the management of the population of both captive and free-ranging wild horses and white-tailed deer. Long-term use of the PZP-based contraceptive vaccines has also demonstrated their safety. Ideally single injection of the contraceptive vaccine should elicit long lasting immune response and desired contraceptive efficacy, which will require development of novel vaccine delivery platforms and more potent adjuvants.
[Mh] Termos MeSH primário: Animais Selvagens
Conservação dos Recursos Naturais/métodos
Anticoncepção Imunológica/veterinária
Vacinas Anticoncepcionais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Feminino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Vaccines, Contraceptive)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


  3 / 301 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28380585
[Au] Autor:Harris EK; Mellencamp MA; Johnston LJ; Shurson GC
[Ti] Título:Growth performance of immunologically castrated pigs slaughtered at 5, 7, or 9 weeks after the second Improvest dose and fed diets containing corn dried distillers grains with solubles.
[So] Source:J Anim Sci;95(2):806-819, 2017 Feb.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Growth performance of immunologically castrated (IC) pigs (863 total) was determined at increasing time intervals between the second Improvest (gonadotropin releasing factor analog-diphtheria toxoid conjugate; Zoetis Inc., Florham Park, NJ) dose and slaughter (TD) and with 4 different dried distillers grains with solubles (DDGS) feeding strategies (FS) in a 4 × 3 factorial arrangement of treatments. The feeding period was divided into 4 separate diet phases. Dietary treatments included 1) corn-soybean meal control diets (PCon), 2) a gradual decrease of dietary DDGS inclusion rate from 40%, 30%, 20%, and 10% in phases 1 to 4 (GD), respectively, 3) feeding 40% DDGS diets in phases 1 to 3 and removal of DDGS from the phase 4 diet (WD), and 4) feeding 40% DDGS diets in all 4 phases (NCon). Pigs received the second Improvest dose at 9 (TD9), 7 (TD7), or 5 (TD5) wk before slaughter. In each group, all pigs were slaughtered on the same day. There were no 3-way interactions among FS, TD, and week of feeding period for any measure of growth performance. Pigs fed PCon and WD had greater ( < 0.05) overall ADFI than pigs fed NCon, especially when slaughtered 9 wk after the second Improvest dose (2.45 and 2.44 vs. 2.31 ± 0.08 kg/d, respectively). This response was partly due to withdrawing DDGS from the diet at 19 wk of age (WD), which led to a tendency ( < 0.10) for increased ADFI from the wk 19 to 21 interval to the wk 21 to 24 interval (3.26 vs. 3.51 ± 0.09 kg/d, respectively). During the same time period, ADFI was unchanged ( > 0.05) in pigs fed PCon, GD, and NCon. Overall G:F was improved ( < 0.05) in TD5 pigs compared with TD9 pigs and tended ( < 0.10) to be improved compared with TD7 pigs. Final BW was similar among pigs fed GD, WD, and PCon (123.1, 122.3, and 125.3 kg, respectively), but pigs fed PCon and GD had greater ( < 0.05) BW than pigs fed NCon (120.0 kg). Throughout the growing-finishing period, BW was similar among TD treatments. The GD FS was more effective than the WD FS in maintaining overall G:F (0.424 and 0.414 ± 0.005, respectively) and ADG (0.94 and 0.93 ± 0.03 kg/d, respectively), which were similar ( > 0.05) to those of pigs fed PCon (0.427 ± 0.005 and 0.96 ± 0.03 kg/d, respectively). Growth performance of pigs fed GD more closely reflected that of pigs fed PCon than that of pigs fed WD. Delaying the second dose of Improvest from 9 to 5 wk before slaughter resulted in improved growth performance.
[Mh] Termos MeSH primário: Ração Animal/análise
Dieta/veterinária
Grãos Comestíveis
Suínos/fisiologia
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal
Animais
Masculino
Orquiectomia/métodos
Feijão de Soja
Vacinas Anticoncepcionais
Zea mays
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Vaccines, Contraceptive)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.0510


  4 / 301 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28006701
[Au] Autor:Marti S; Jackson JA; Slootmans N; Lopez E; Hodge A; Pérez-Juan M; Devant M; Amatayakul-Chantler S
[Ad] Endereço:IRTA-Ruminant Production, Animal Nutrition, Management, and Welfare Research Group, Torre Marimon, Caldes de Montbui, Barcelona, Spain.
[Ti] Título:Effects on performance and meat quality of Holstein bulls fed high concentrate diets without implants following immunological castration.
[So] Source:Meat Sci;126:36-42, 2017 Apr.
[Is] ISSN:1873-4138
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the effect of the GnRH vaccine on the performance and meat quality of Holstein bulls fed high concentrate diets. A total of 493 approximately 7month old bulls (initial BW 298±1.2kg) were allocated into 3 treatment groups, intact bulls (n=164), animals surgically castrated at 15 to 17d of the study (n=164), and animals vaccinated on 0 and 28d of the study with the GnRH vaccine (n=165). Animals were slaughtered between 131 and 133d and carcass quality was evaluated. Hot carcass weight, dressing percentage, fat classification and meat quality parameters did not differ significantly between surgically castrated and vaccinated animals but differed (P<0.05) from intact bulls. Carcass classification, pH at 26h, and fat color were not affected by treatment.
[Mh] Termos MeSH primário: Ração Animal/análise
Qualidade dos Alimentos
Carne Vermelha
Vacinas Anticoncepcionais/administração & dosagem
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal
Animais
Composição Corporal
Bovinos
Dieta/veterinária
Relação Dose-Resposta a Droga
Hormônio Liberador de Gonadotropina/administração & dosagem
Concentração de Íons de Hidrogênio
Modelos Lineares
Masculino
Orquiectomia/veterinária
Vacinação/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vaccines, Contraceptive); 33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE


  5 / 301 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27862374
[Au] Autor:Vansandt LM; Kutzler MA; Fischer AE; Morris KN; Swanson WF
[Ad] Endereço:Center for Conservation and Research of Endangered Wildlife, Cincinnati Zoo and Botanical Garden, Cincinnati, OH, USA.
[Ti] Título:Safety and effectiveness of a single and repeat intramuscular injection of a GnRH vaccine (GonaCon™) in adult female domestic cats.
[So] Source:Reprod Domest Anim;52 Suppl 2:348-353, 2017 Apr.
[Is] ISSN:1439-0531
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Sterilization is a key strategy to reduce the number of domestic cats entering and killed in shelters each year. However, surgical sterilization is expensive and labour-intensive and cannot fully address the 70 million free-roaming cats estimated to exist in the United States. GonaCon™ is a gonadotropin-releasing hormone vaccine originally developed for use as a wildlife immunocontraceptive. An earlier formulation was tested in domestic cats and found to be safe and effective for long-term contraception. However, the current Environmental Protection Agency (EPA)-registered formulation consists of a different antigen-carrier protein and increased antigen concentration and has never been tested in cats. A pilot study was undertaken to evaluate the short-term safety of a single GonaCon immunization, assess the consequences of vaccinated cats receiving an accidental second GonaCon injection and determine the humoral immune response to immunization. During Phase 1, cats in Group A (n = 3) received a single intramuscular injection of GonaCon and Group B (n = 3) received a single intramuscular injection of saline. During Phase 2, Group A received a second GonaCon injection and Group B received their initial GonaCon injection. All cats developed GnRH antibodies within 30 days of vaccine administration. The endpoint titre (1:1,024,000) was similar among all cats, and levels remained high throughout the duration of the study. Four cats developed a sterile, painless, self-limiting mass at the site of injection. The mean number of days to mass development was 110.3 (range, 18-249 days). In conclusion, this preliminary study suggests that the EPA-registered GonaCon formulation is safe for continued testing in domestic cats, an accidental revaccination should not increase the risk of a vaccine reaction and the EPA-registered formulation effectively elicits a strong humoral immune response.
[Mh] Termos MeSH primário: Gatos
Anticoncepção Imunológica/veterinária
Hormônio Liberador de Gonadotropina/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos/sangue
Anticoncepção/métodos
Anticoncepção/veterinária
Anticoncepção Imunológica/efeitos adversos
Anticoncepção Imunológica/métodos
Feminino
Injeções Intramusculares/efeitos adversos
Injeções Intramusculares/veterinária
Projetos Piloto
Estados Unidos
United States Environmental Protection Agency
Vacinas Anticoncepcionais/administração & dosagem
Vacinas Anticoncepcionais/efeitos adversos
Vacinas Anticoncepcionais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Vaccines, Contraceptive); 33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1111/rda.12853


  6 / 301 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27614179
[Au] Autor:Pérez-Linares C; Bolado-Sarabia L; Figueroa-Saavedra F; Barreras-Serrano A; Sánchez-López E; Tamayo-Sosa AR; Godina AA; Ríos-Rincón F; García LA; Gallegos E
[Ad] Endereço:Instituto de Investigaciones en Ciencias Veterinarias, Universidad Autónoma de Baja California, A. Obregón y J. Carrillo s/n Col. Nueva, Mexicali, Baja California CP. 21100, Mexico.
[Ti] Título:Effect of immunocastration with Bopriva on carcass characteristics and meat quality of feedlot Holstein bulls.
[So] Source:Meat Sci;123:45-49, 2017 Jan.
[Is] ISSN:1873-4138
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To evaluate the effect of immunocastration on carcass and meat characteristics, Holstein bulls aged between 7 and 8months with a live weight of 232±1.19kg were given two separate treatments, placebo (intact bulls) versus Bopriva, and then slaughtered after approximately 239days of fattening. While the testosterone levels in intact bulls remained at 0.42ng/ml throughout the study, by day 181, differences (P<0.05) were observed in immunized bulls, with values of 0.21ng/ml. The carcasses of animals treated with Bopriva recorded both a higher hot carcass weight (HCW) and a cold carcass weight (CCW), as well as higher dorsal fat density, marbling and KPH (P<0.05); however, no differences (P>0.05) were observed in the Longissimus lumborum area. No significant differences (P>0.05) were recorded between the treatments for pH, L*, a*, b* C* and H*. The carcasses of the animals treated with Bopriva were heavier, with higher dorsal fat density and marbling score.
[Mh] Termos MeSH primário: Castração/métodos
Qualidade dos Alimentos
Imunização/veterinária
Carne Vermelha/análise
Vacinas Anticoncepcionais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Bovinos/imunologia
Cor
Concentração de Íons de Hidrogênio
Masculino
Músculo Esquelético/química
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vaccines, Contraceptive); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE


  7 / 301 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26708619
[Au] Autor:Joonè CJ; Bertschinger HJ; Gupta SK; Fosgate GT; Arukha AP; Minhas V; Dieterman E; Schulman ML
[Ad] Endereço:Section of Reproduction, Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
[Ti] Título:Ovarian function and pregnancy outcome in pony mares following immunocontraception with native and recombinant porcine zona pellucida vaccines.
[So] Source:Equine Vet J;49(2):189-195, 2017 Mar.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:REASONS FOR PERFORMING STUDY: Few studies have investigated ovarian function in the mare undergoing porcine zona pellucida (pZP) immunocontraception despite reported ovarian dysfunction in other species. OBJECTIVES: This study aimed to describe ovarian function and oestrous cyclicity in pony mares following treatment with either the conventional pZP vaccine or a novel recombinant form of the vaccine derived from porcine ZP3 and ZP4 (reZP). In addition, the contraceptive efficacy of pZP vs. reZP was assessed. STUDY DESIGN: Blinded, randomised, prospective clinical trial. METHODS: Mares (n = 21) were randomised into 3 groups of 7: Group I received the pZP vaccine, with a booster 5 weeks later; Group II received the reZP vaccine, with a booster 5 weeks later; and Group III (controls) received 2 treatments, 5 weeks apart, of saline and adjuvant alone. Mares underwent weekly monitoring via transrectal palpation and ultrasound examination of the reproductive tract, with daily monitoring during oestrus. Data were collected over a 24 week period coinciding with the physiological breeding season; treatments commenced in Week 4. Serum samples were obtained for antibody titres and ovarian steroid level analyses at 7 day intervals. Cycling mares were bred via fresh semen artificial inseminations over a maximum of 2 consecutive oestrous cycles, commencing 5 weeks post booster vaccination. RESULTS: Control mares cycled throughout the trial. After treatment, 6 of 7 pZP mares (86%) and one reZP mare (14%) had an extended anoestrus that correlated with basal serum oestradiol and progesterone levels. All mares resumed cyclicity by 10 months post treatment. Pregnancies were diagnosed in all controls, 4 reZP- (57%) and none of the pZP-immunised mares. CONCLUSIONS: The current study demonstrates the reversible suppression of ovarian function in pony mares following treatment with pZP. The effect of the reZP vaccine on pregnancy outcome requires further investigation.
[Mh] Termos MeSH primário: Anticoncepção Imunológica/veterinária
Ovário/fisiologia
Prenhez
Vacinas Anticoncepcionais/imunologia
Zona Pelúcida/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos/sangue
Estradiol/sangue
Feminino
Gravidez
Resultado da Gravidez
Progesterona/sangue
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antibodies); 0 (Vaccines, Contraceptive); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151229
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12557


  8 / 301 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27898886
[Au] Autor:Moore KL; Mullan BP; Kim JC; Payne HG; Dunshea FR
[Ti] Título:Effect of feed restriction and initial body weight on growth performance, body composition, and hormones in male pigs immunized against gonadotropin-releasing factor.
[So] Source:J Anim Sci;94(9):3966-3977, 2016 Sep.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pigs immunized against gonadotropin-releasing factor (GnRF) have increased carcass fatness compared to entire males; however, the timing of this increase in fatness after the second immunization against GnRF has not been determined. An experiment was conducted to identify and compare the growth performance, body composition, and physiological changes in immunocastrated males (IC males) at different BW and feeding levels. A total of 64 pigs were used in a 2 × 2 × 2 factorial experiment with the treatments being 1) sex (entire males or IC males), 2) initial BW (45.9 kg [light] or 78.3 kg [heavy]), and 3) feeding regime (2.5 times maintenance [restricted] or ad libitum). The pigs were individually housed, and the diets were fed for 4 wk after the second immunization against GnRF until slaughter at either 68.4 kg BW (light) or 105.8 kg BW (heavy). Immunocastrated males on a restricted feed intake had a lower ADG compared to entire males from d 15 to 28 and d 0 to 28 ( 0.011 and 0.011, respectively). Fat deposition was not affected by sex from d 0 to 14, but from d 15 to 28 IC males deposited 45 g/d more fat than entire males ( = 0.025). Immunocastrated male pigs fed ad libitum deposited 87 g/d more fat from d 15 to 28 than entire males fed ad libitum ( = 0.036). However, there was no difference in fat deposition between IC males and entire males when feed intake was restricted from d 15 to 28. Plasma urea nitrogen levels were greater in IC males compared to entire males from d 7 after the second immunization against GnRF ( 0.05 for d 7, 10, 14, 21, and 28). Plasma concentrations of IGF-1 were lower for IC males compared to entire males on d 3, 7, 10, and 28 ( 0.05 for all days). The following conclusions were made: 1) when pigs are immunized at a light BW (50 kg) and/or are on a restricted feed intake, they have a reduced propensity to deposit fat; however, the restriction in feed intake adversely affects growth rate. 2) The majority of fat deposition for males immunized at heavy BW (80 kg) occurs from d 15 to 28 after the second immunization against GnRF.
[Mh] Termos MeSH primário: Hormônio Liberador de Gonadotropina/imunologia
Orquiectomia/veterinária
Suínos/fisiologia
Vacinas Anticoncepcionais/imunologia
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Composição Corporal/fisiologia
Peso Corporal/fisiologia
Imunização
Fator de Crescimento Insulin-Like I
Masculino
Orquiectomia/métodos
Suínos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vaccines, Contraceptive); 33515-09-2 (Gonadotropin-Releasing Hormone); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016-0403


  9 / 301 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27667457
[Au] Autor:Wang Y; Zhang B; Zhang J; Luo J; Adila A; Zhang F
[Ad] Endereço:Xinjiang Key Laboratory of Biological Resource and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China.
[Ti] Título:[Canine zona pellucida 3 (CZP3) DNA vaccination reduces mouse fertility effectively].
[So] Source:Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi;32(10):1331-1335, 2016 Oct.
[Is] ISSN:1007-8738
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Objective To construct a DNA contraception vaccine targeting canine zona pellucida 3 (CZP3) antigen and assess the immunological efficacy and contraceptive effect of the vaccine. Methods The CZP3 gene was amplified from total RNA of canine ovary by reverse transcription PCR and analyzed by bioinformatics, such as ProtScale, TMHMM, Signal P, InterProScan, PREDICT PROTEIN, homology modeling, etc. The constructed DNA vaccine pcDNA-CZP3 was used to vaccinate mice, and then its immune effect and contraceptive effect were evaluated in the mice. Results The CZP3 gene had 426 amino acids with two hydrophobic regions at its N-terminal and C-terminal, respectively. The top 22 amino acids at the N-terminal of the CZP3 was the signal peptide and there was a transmembranous helix from extracellular to intracellular at the C-terminal. CZP3 also had 8 B cell epitopes. The DNA contraception vaccine pcDNA3-CZP3 induced high levels of antibody and lower average litter size of mouse compared with the blank and negative control groups significantly. Conclusion The canine contraception DNA vaccine pcDNA-CZP3 has been successfully constructed and it can reduce the mouse fertility remarkably.
[Mh] Termos MeSH primário: Anticoncepção Imunológica/veterinária
Cães/fisiologia
Fertilidade/efeitos dos fármacos
Reprodução/efeitos dos fármacos
Vacinas Anticoncepcionais/imunologia
Vacinas de DNA/imunologia
Glicoproteínas da Zona Pelúcida/imunologia
Zona Pelúcida/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos/imunologia
Anticoncepção Imunológica/instrumentação
Anticoncepção Imunológica/métodos
Cães/imunologia
Feminino
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Vacinação
Vacinas Anticoncepcionais/administração & dosagem
Vacinas Anticoncepcionais/genética
Vacinas de DNA/administração & dosagem
Vacinas de DNA/genética
Glicoproteínas da Zona Pelúcida/administração & dosagem
Glicoproteínas da Zona Pelúcida/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Vaccines, Contraceptive); 0 (Vaccines, DNA); 0 (Zona Pellucida Glycoproteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


  10 / 301 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27482668
[Au] Autor:Van den Broeke A; Leen F; Aluwé M; Ampe B; Van Meensel J; Millet S
[Ti] Título:The effect of GnRH vaccination on performance, carcass, and meat quality and hormonal regulation in boars, barrows, and gilts.
[So] Source:J Anim Sci;94(7):2811-20, 2016 Jul.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assess the effect of GnRH vaccination in boars (BO), barrows (BA), and gilts (GI) slaughtered at an average BW of 133 kg. Forty BO, 40 BA, and 40 GI were housed individually, fed ad libitum, and divided into 2 groups of 20 pigs per sex, a control group (CON) and a GnRH vaccinated group (IC). The IC group received 2 injections of GnRH vaccine (Improvac) at 70 and 105 kg. In BA, GnRH vaccination had minor effects on performance. Observed effects in BO and GI are therefore probably not caused by the GnRH vaccination itself but by the subsequent withdrawal of gonadal hormones. In BO, the increased feed intake after GnRH vaccination ( < 0.001), accompanied by a fall in estradiol and testosterone levels, led to faster growth ( = 0.014), increased back fat thickness ( = 0.021), and a tendency for a decreased meat percentage ( = 0.052). GnRH vaccination of BO decreased the boar taint-related sensory attribute scores similar to the levels of BA and GI ( < 0.001). In GI, the increased feed intake after GnRH vaccination ( < 0.001), accompanied by low progesterone levels, led to faster growth ( < 0.001), increased back fat thickness ( = 0.018), decreased meat percentage ( = 0.032), and a decreased shear force ( = 0.002) without significant differences in the sensory profile.
[Mh] Termos MeSH primário: Hormônio Liberador de Gonadotropina/administração & dosagem
Carne Vermelha/normas
Suínos/fisiologia
Vacinação/veterinária
Vacinas Anticoncepcionais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Composição Corporal
Peso Corporal
Dieta/veterinária
Ingestão de Alimentos
Feminino
Hormônios/sangue
Masculino
Fatores Sexuais
Suínos/crescimento & desenvolvimento
Suínos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones); 0 (Vaccines, Contraceptive); 33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2015-0173



página 1 de 31 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde