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[PMID]:28098798
[Au] Autor:Olczyk P; Komosinska-Vassev K; Ramos P; Mencner L; Olczyk K; Pilawa B
[Ad] Endereço:Department of Community Pharmacy, School of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Kasztanowa 3, 41-200 Sosnowiec, Poland. polczyk@sum.edu.pl.
[Ti] Título:Free Radical Scavenging Activity of Drops and Spray Containing Propolis-An EPR Examination.
[So] Source:Molecules;22(1), 2017 Jan 13.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The influence of heating at a temperature of 50 °C and UV-irradiation of propolis drops and spray on their free radical scavenging activity was determined. The kinetics of interactions of the propolis samples with DPPH free radicals was analyzed. Interactions of propolis drops and propolis spray with free radicals were examined by electron paramagnetic resonance spectroscopy. A spectrometer generating microwaves of 9.3 GHz frequency was used. The EPR spectra of the model DPPH free radicals were compared with the EPR spectra of DPPH in contact with the tested propolis samples. The antioxidative activity of propolis drops and propolis spray decreased after heating at the temperature of 50 °C. A UV-irradiated sample of propolis drops more weakly scavenged free radicals than an untreated sample. The antioxidative activity of propolis spray increased after UV-irradiation. The sample of propolis drops heated at the temperature of 50 °C quenched free radicals faster than the unheated sample. UV-irradiation weakly changed the kinetics of propolis drops or spray interactions with free radicals. EPR analysis indicated that propolis drops and spray should not be stored at a temperature of 50 °C. Propolis drops should not be exposed to UV-irradiation.
[Mh] Termos MeSH primário: Depuradores de Radicais Livres/química
Soluções Oftálmicas/efeitos da radiação
Própole/efeitos da radiação
Raios Ultravioleta/efeitos adversos
[Mh] Termos MeSH secundário: Compostos de Bifenilo/antagonistas & inibidores
Espectroscopia de Ressonância de Spin Eletrônica
Temperatura Alta
Soluções Oftálmicas/química
Sprays Orais
Oxirredução/efeitos da radiação
Picratos/antagonistas & inibidores
Própole/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Ophthalmic Solutions); 0 (Oral Sprays); 0 (Picrates); 9009-62-5 (Propolis); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE


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[PMID]:28088167
[Au] Autor:Mukherjee PK; Esper F; Buchheit K; Arters K; Adkins I; Ghannoum MA; Salata RA
[Ad] Endereço:Center for Medical Mycology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA.
[Ti] Título:Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections.
[So] Source:BMC Infect Dis;17(1):74, 2017 Jan 14.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Current prevention options for upper respiratory infections (URIs) are not optimal. We conducted a randomized, double-blinded, placebo-controlled pilot clinical trial to evaluate the safety and efficacy of ARMS-I™ (currently marketed as Halo™) in the prevention of URIs. METHODS: ARMS-I is patented novel formulation for the prevention and treatment of influenza, comprising a broad-spectrum antimicrobial agent (cetylpyridinium chloride, CPC) and components (glycerin and xanthan gum) that form a barrier on the host mucosa, thus preventing viral contact and invasion. Healthy adults (18-45 years of age) were randomized into ARMS-I or placebo group (50 subjects each). The drug was sprayed intra-orally (3× daily) for 75 days. The primary objectives were to establish whether ARMS-I decreased the frequency, severity or duration of URIs. Secondary objectives were to evaluate safety, tolerability, rate of virus detection, acceptability and adherence; effect on URI-associated absenteeism and medical visits; and effect of prior influenza vaccination on study outcomes. RESULTS: Of the 94 individuals who completed the study (placebo: n = 44, ARMS-I: n = 50), six presented with confirmed URI (placebo: 4, ARMS-I: 2), representing a 55% relative reduction, albeit this was statistically not significant). Influenza, coronavirus or rhinovirus were detected in three participants; all in the placebo group. Moreover, frequency of post-treatment exit visits was reduced by 55% in ARMS-I compared to the placebo group (N = 4 and 2, respectively). Fever was reported only in the placebo group. ARMS-I significantly reduced the frequency and severity of cough and sore throat, and duration of cough (P ≤ .019 for all comparisons). ARMS-I was safe, well tolerated, had high acceptability and high adherence to medication use. Medical visits occurred only in the placebo group while absenteeism did not differ between the two arms. Prior influenza vaccination had no effect on study outcome. CONCLUSIONS: This randomized proof-of-concept clinical trial demonstrated that ARMS-I tended to provide protection against URIs in the enrolled study participants, while reducing severity and duration of cough and sore throat. A clinical trial with a larger number of study participants is warranted. TRIAL REGISTRATION: ClinicalTrials.gov NCT02644135 (retrospectively registered).
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Cetilpiridínio/uso terapêutico
Resfriado Comum/prevenção & controle
Infecções por Coronavirus/prevenção & controle
Influenza Humana/prevenção & controle
Infecções Respiratórias/prevenção & controle
[Mh] Termos MeSH secundário: Administração Oral
Administração Tópica
Adolescente
Adulto
Resfriado Comum/complicações
Coronavirus/isolamento & purificação
Infecções por Coronavirus/complicações
Tosse/etiologia
Tosse/prevenção & controle
Método Duplo-Cego
Feminino
Glicerol/uso terapêutico
Seres Humanos
Vacinas contra Influenza/uso terapêutico
Influenza Humana/complicações
Masculino
Meia-Idade
Sprays Orais
Orthomyxoviridae/isolamento & purificação
Faringite/etiologia
Faringite/prevenção & controle
Projetos Piloto
Polissacarídeos Bacterianos/uso terapêutico
Infecções Respiratórias/complicações
Rhinovirus/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Influenza Vaccines); 0 (Oral Sprays); 0 (Polysaccharides, Bacterial); CUB7JI0JV3 (Cetylpyridinium); PDC6A3C0OX (Glycerol); TTV12P4NEE (xanthan gum)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170116
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-016-2177-8


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[PMID]:27931522
[Au] Autor:Adachi K; Umezaki T
[Ad] Endereço:Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: adakazu@qent.med.kyushu-u.ac.jp.
[Ti] Título:Effectiveness of fibrin coating in the management of web formation after laryngomicrosurgery.
[So] Source:Am J Otolaryngol;38(1):1-6, 2017 Jan - Feb.
[Is] ISSN:1532-818X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To explore the effectiveness of fibrin coating in reducing web formation after endoscopic management of the anterior commissure of the larynx. MATERIALS AND METHODS: Using a spray device that is generally used for laparoscopic operations, we covered the wound with fibrin glue (Bolheal®) to avoid web formation. This technique was employed in cases wherein the anterior commissure was mainly managed by laser operation; the glue was sprayed after vaporization. Fibrinogen was first sprayed and the wound was properly soaked with a swab, which was followed by application of thrombin. We used this method in 17 cases and evaluated voice function by acoustic analysis - pitch perturbation quotient (PPQ) and amplitude perturbation quotient (APQ) - and maximum phonation time (MPT) before and after the operation. RESULTS: No severe web formation was observed at three months after the operation. PPQ values improved from 3.048±2.801% to 0.653±0.463% (p<0.05, paired t-test). APQ values improved from 7.996±5.003% to 3.042±1.872% (p<0.05, paired t-test). Voice quality did not worsen in any of the cases. MPT values improved from 17.2±10.8s to 26.7±14.2s (p<0.05, paired t-test) Voice function improved 3months after the operation in all cases. CONCLUSION: The fibrin coating method is an easy and effective approach to avoid web formation without creating cervical wounds in cases that require handling of the anterior commissure under laryngomicrosurgery.
[Mh] Termos MeSH primário: Adesivo Tecidual de Fibrina/uso terapêutico
Neoplasias Laríngeas/cirurgia
Laringoscopia/métodos
Microcirurgia/métodos
Aderências Teciduais/prevenção & controle
Disfunção da Prega Vocal/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Estudos de Coortes
Feminino
Seres Humanos
Cuidados Intraoperatórios/métodos
Neoplasias Laríngeas/patologia
Laringectomia/efeitos adversos
Laringectomia/métodos
Laringoscopia/efeitos adversos
Masculino
Microcirurgia/efeitos adversos
Meia-Idade
Sprays Orais
Complicações Pós-Operatórias/prevenção & controle
Estudos Retrospectivos
Resultado do Tratamento
Qualidade da Voz
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Fibrin Tissue Adhesive); 0 (Oral Sprays)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE


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[PMID]:28025646
[Au] Autor:Yang HL; Liu FC; Tsai SC; Tsay PK; Lin HT; Liu HE
[Ad] Endereço:Department of Nursing, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
[Ti] Título:Ketorolac Tromethamine Spray Prevents Postendotracheal-Intubation-Induced Sore Throat after General Anesthesia.
[So] Source:Biomed Res Int;2016:4582439, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:. Postoperative sore throat is one of the major complaints of general anesthesia in the postanesthesia care unit. This prospective study investigated the preventive effect of ketorolac tromethamine spray in postendotracheal-intubation-induced sore throat after general anesthesia. . Surgical patients undergoing general anesthesia with endotracheal intubation were recruited from a medical center. Patients were randomly assigned to group K (treated with 5% ketorolac tromethamine spray) or group D (treated with distilled water spray). Before intubation, each endotracheal tube was sprayed with the appropriate solution by physicians over the 20 cm length of the cuff. Each group comprised 95 patients fitting the inclusion and exclusion criteria for whom complete data sets were collected. The intensity of the sore throat was measured at 1, 3, 6, and 24 h after surgery, and data were compared. . The two groups had similar characteristics. Postoperative sore throat was significantly less frequent in group K than in group D ( < 0.001) and the pain intensity was significantly lower in group K than in group D at each time point (all < 0.001). . This study demonstrated that preanesthesia 5% ketorolac tromethamine spray could effectively decrease postendotracheal-intubation-induced sore throat in patients undergoing general anesthesia.
[Mh] Termos MeSH primário: Anestesia Geral/efeitos adversos
Intubação Intratraqueal/efeitos adversos
Cetorolaco de Trometamina/administração & dosagem
Sprays Orais
Faringite/prevenção & controle
Complicações Pós-Operatórias/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Faringite/etiologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oral Sprays); 4EVE5946BQ (Ketorolac Tromethamine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1155/2016/4582439


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[PMID]:27763916
[Au] Autor:Pedoto A; Desiderio DP; Amar D; Downey RJ
[Ad] Endereço:From the *Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; and †Thoracic Division, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
[Ti] Título:Hemodynamic Instability Following Airway Spray Cryotherapy.
[So] Source:Anesth Analg;123(5):1302-1306, 2016 Nov.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Spray cryotherapy (SCT) of airway lesions is used to effectively palliate respiratory symptoms related to airway obstruction, but significant intraoperative hemodynamic complications have been noted. We reviewed the experience at a single institution using SCT for the treatment of obstructive airway tumors. METHODS: A retrospective review of a single institution experience with intraoperative and postoperative hemodynamic complications associated with SCT was performed. Descriptive statistics were performed. RESULTS: Between June 2009 and April 2010, 34 treatment sessions were performed on 28 patients. Median age was 60 years (range, 15-88 years). Tumor characteristics were as follows: 13 primary lung cancers (43%), 11 pulmonary metastases (50%), 1 direct extension of an esophageal cancer (3%), and 2 benign pulmonary lesions (7%). Twenty-one tumors (75%) were distal to the carina; 14 (50%) were >95% occlusive. Median procedure length was 78 minutes (range, 15-176 minutes). Eleven sessions (31%) led to severe hypotension and/or bradycardia, with 2 patients requiring cardiopulmonary resuscitation. One patient died intraoperatively after cardiac arrest; a second patient was stable intraoperatively but died within 24 hours of SCT. Four patients required reintubation and short-term mechanical ventilation. CONCLUSIONS: Unpredictable life-threatening hemodynamic instability can follow endobronchial SCT. We propose that the most likely cause is pulmonary venous gaseous emboli entering the right heart, the coronary arteries, and the systemic circulation. Although SCT may offer advantages over airway laser therapy (such as no risk of fire and rapid hemostasis), further study is needed to delineate the relative likelihood of therapeutic benefit versus catastrophic complications.
[Mh] Termos MeSH primário: Obstrução das Vias Respiratórias/terapia
Crioterapia/efeitos adversos
Hemodinâmica/fisiologia
Sprays Orais
Traqueia/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Obstrução das Vias Respiratórias/diagnóstico
Feminino
Hemodinâmica/efeitos dos fármacos
Seres Humanos
Intubação Intratraqueal/efeitos adversos
Intubação Intratraqueal/métodos
Masculino
Meia-Idade
Respiração Artificial/efeitos adversos
Respiração Artificial/métodos
Estudos Retrospectivos
Traqueia/efeitos dos fármacos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Oral Sprays)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


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[PMID]:27732980
[Au] Autor:Vermersch P; Trojano M
[Ad] Endereço:University of Lille, CHU Lille, LIRIC-INSERM U995, FHU Imminent, Lille, France.
[Ti] Título:Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice.
[So] Source:Eur Neurol;76(5-6):216-226, 2016.
[Is] ISSN:1421-9913
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex®) is an add-on therapy for moderate-to-severe multiple sclerosis (MS)-related drug-resistant spasticity (MSS). AIM: The MOVE-2 EU study collected data from everyday clinical practice concerning the effectiveness and tolerability of THC:CBD. METHODS: This was an observational, prospective, multicentre, non-interventional study. Patients with resistant MSS prescribed add-on THC:CBD oromucosal spray according to approved labelling, were followed for 3 months. After 1 month, only responders (≥20% improvement in spasticity) continued treatment. The main endpoints were the evolution of MSS and associated symptoms, quality of life (QoL) and tolerability. RESULTS: Four hundred and thirty three patients (55% female) were recruited (98% in Italy). The mean duration of MSS was 7.4 years and baclofen was used by 78.1% of participants. Three hundred and forty nine participants continued with THC:CBD oromucosal spray after 1 month, and 281 after 3 months. THC:CBD mean dosage was 6 sprays/day. MSS scores and spasticity-related symptoms (spasms, fatigue, pain, sleep quality and bladder dysfunction) were significantly improved by THC:CBD at 3 months, as were activities of daily living, and QoL (EQ-5D VAS). Adverse events, none of which were severe or serious, were reported by 10.4% of patients. CONCLUSIONS: In everyday clinical practice, THC:CBD oromucosal spray provided symptomatic relief of MSS and related troublesome symptoms.
[Mh] Termos MeSH primário: Esclerose Múltipla/complicações
Espasticidade Muscular/tratamento farmacológico
Espasticidade Muscular/etiologia
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Atividades Cotidianas
Adulto
Baclofeno/uso terapêutico
Canabidiol
Dronabinol
Combinação de Medicamentos
Feminino
Seres Humanos
Itália
Masculino
Meia-Idade
Esclerose Múltipla/tratamento farmacológico
Sprays Orais
Extratos Vegetais/efeitos adversos
Estudos Prospectivos
Qualidade de Vida
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Oral Sprays); 0 (Plant Extracts); 19GBJ60SN5 (Cannabidiol); 7J8897W37S (Dronabinol); H789N3FKE8 (Baclofen); K4H93P747O (nabiximols)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


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[PMID]:27724992
[Au] Autor:Todd JJ; McSorley EM; Pourshahidi LK; Madigan SM; Laird E; Healy M; Magee PJ
[Ad] Endereço:1Northern Ireland Centre for Food and Health,University of Ulster,Coleraine BT52 1SA,UK.
[Ti] Título:Vitamin D3 supplementation in healthy adults: a comparison between capsule and oral spray solution as a method of delivery in a wintertime, randomised, open-label, cross-over study.
[So] Source:Br J Nutr;116(8):1402-1408, 2016 Oct.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vitamin D is typically supplied in capsule form, both in trials and in clinical practice. However, little is known regarding the efficacy of vitamin D administered via oral sprays - a method that primarily bypasses the gastrointestinal absorption route. This study aimed to compare the efficacy of vitamin D3 liquid capsules and oral spray solution in increasing wintertime total 25-hydroxyvitamin D (25(OH)D) concentrations. In this randomised, open-label, cross-over trial, healthy adults (n 22) received 3000 IU (75 µg) vitamin D3 daily for 4 weeks in either capsule or oral spray form. Following a 10-week washout phase, participants received the opposite treatment for a final 4 weeks. Anthropometrics and fasted blood samples were obtained before and after supplementation, with samples analysed for total 25(OH)D, creatinine, intact parathyroid hormone and adjusted Ca concentrations. At baseline, vitamin D sufficiency (total 25(OH)D>50 nmol/l), insufficiency (31-49 nmol/l) and clinical deficiency (<30 nmol/l) were evident in 59, 23 and 18 % of the participants, respectively. Overall, baseline total mean 25(OH)D concentration averaged 59·76 (sd 29·88) nmol/l, representing clinical sufficiency. ANCOVA revealed no significant difference in the mean and standard deviation change from baseline in total 25(OH)D concentrations between oral spray and capsule supplementation methods (26·15 (sd 17·85) v. 30·38 (sd 17·91) nmol/l, respectively; F=1·044, adjusted r 2 0·493, P=0·313). Oral spray vitamin D3 is an equally effective alternative to capsule supplementation in healthy adults.
[Mh] Termos MeSH primário: Colecalciferol/administração & dosagem
Suplementos Nutricionais
Deficiência de Vitamina D/prevenção & controle
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D 2/sangue
Adulto
Biomarcadores/sangue
Calcifediol/sangue
Cálcio/sangue
Cápsulas
Colecalciferol/efeitos adversos
Colecalciferol/uso terapêutico
Estudos Cross-Over
Suplementos Nutricionais/efeitos adversos
Feminino
Seres Humanos
Análise de Intenção de Tratamento
Perda de Seguimento
Masculino
Irlanda do Norte
Sprays Orais
Hormônio Paratireóideo/sangue
Cooperação do Paciente
Estações do Ano
Índice de Gravidade de Doença
Deficiência de Vitamina D/sangue
Deficiência de Vitamina D/dietoterapia
Deficiência de Vitamina D/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Capsules); 0 (Oral Sprays); 0 (PTH protein, human); 0 (Parathyroid Hormone); 1C6V77QF41 (Cholecalciferol); 21343-40-8 (25-Hydroxyvitamin D 2); P6YZ13C99Q (Calcifediol); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


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[PMID]:27628929
[Au] Autor:Kawano Y; Imamura A; Nakamura T; Akaishi M; Satoh M; Hanawa T
[Ad] Endereço:Faculty of Pharmaceutical Science, Tokyo University of Science.
[Ti] Título:Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate.
[So] Source:Chem Pharm Bull (Tokyo);64(12):1659-1665, 2016 Dec 01.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The stomatitis caused by anticancer agents and radiation therapy deteriorates patient QOL, potentially causing eating disorders as a result of pain. Although gargling and ointments can be used in the treatment of stomatitis, patients must spit out mouthwash after use, while ointment application requires a finger to be inserted into the oral cavity. In contrast, sprays eliminate these potential compliance problems. Therefore, we developed a stomatitis spray that remains on the oral mucosa. It has been reported that irsogladine maleate (IM) is effective against stomatitis via oral administration. IM is water insoluble; thus, it was dissolved with various cyclodextrins (CDs). Furthermore, we examined combination with gum ghatti (GG), a mucoadhesive polymer. The interaction between mucin and GG was examined by Quartz Crystal Microbalance with Dissipation monitoring. We found that GG exhibited mucoadhesion. Furthermore, we examined the healing effects of IM on stomatitis in a stomatitis model hamster. We found that stomatitis healed after direct application of IM. However, the model used in this experiment is not based on stomatitis caused by anticancer agents. Further study is therefore necessary.
[Mh] Termos MeSH primário: Sprays Orais
Estomatite/tratamento farmacológico
Triazinas/administração & dosagem
Triazinas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/administração & dosagem
Antineoplásicos/efeitos adversos
Antineoplásicos/uso terapêutico
Modelos Animais de Doenças
Masculino
Mesocricetus
Estomatite/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Oral Sprays); 0 (Triazines); QBX79NZC1D (irsogladine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170126
[Lr] Data última revisão:
170126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE


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[PMID]:27572326
[Au] Autor:Hofauer B; Mansour N; Heiser C; Straßen U; Bas M; Knopf A
[Ad] Endereço:Otorhinolaryngology/Head and Neck Surgery, Klinikum rechts der Isar, Technical University Munich, Ismaningerstr. 22, 81675, Munich, Germany. b.hofauer@tum.de.
[Ti] Título:Effect of liposomal local therapy on salivary glands in acoustic radiation force impulse imaging in Sjögren's syndrome.
[So] Source:Clin Rheumatol;35(10):2597-601, 2016 Oct.
[Is] ISSN:1434-9949
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to evaluate the utility of acoustic radiation force impulse (ARFI) imaging as a monitoring tool for the effect of a liposomal local therapy in patients with dry mouth symptoms due to primary Sjögren's syndrome (pSS). Fifty patients with pSS, diagnosed according to the American-European Consensus Group (AECG) criteria, were included. Clinical data were collected, and sonographic examination including ARFI imaging of the parotid and submandibular glands was performed. Subjective symptoms were evaluated via visual analogue scales (VAS), and the unstimulated whole salivary flow was measured. After a two-month period of liposomal local therapy, sonographic examination was repeated and both subjective and objective symptoms were re-evaluated. Before local treatment, the mean ARFI value of parotid glands was 2.96 m/s (SD 0.97). Mean ARFI value of the submandibular glands was 2.09 m/s (SD 0.71). After the two-month treatment period, a significant decline of ARFI values in the parotid glands to a value of 2.34 m/s (SD 0.70, p < 0.001) could be observed. The submandibular glands did not show any significant change. Further, a significant reduction of the subjective sensation of dry mouth symptoms could be observed (p = 0.0001). With the application of ARFI imaging, a decline in parotid gland stiffness could be observed in patients with primary Sjögren's Syndrome accompanied by a significant improvement of the subjective sensation of dry mouth symptoms. The seromucous submandibular glands did not show any changes compared to the serous parotid glands.
[Mh] Termos MeSH primário: Técnicas de Imagem por Elasticidade/métodos
Lipossomos/uso terapêutico
Glândulas Salivares/diagnóstico por imagem
Síndrome de Sjogren/terapia
Xerostomia/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Sprays Orais
Síndrome de Sjogren/diagnóstico por imagem
Resultado do Tratamento
Xerostomia/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Liposomes); 0 (Oral Sprays)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160831
[St] Status:MEDLINE
[do] DOI:10.1007/s10067-016-3395-6


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[PMID]:27126336
[Au] Autor:Müller D; Lindemann T; Shah-Hosseini K; Scherner O; Knop M; Bilstein A; Mösges R
[Ad] Endereço:Institute for Medical Statistics, Informatics and Epidemiology (IMSIE), Faculty of Medicine, University of Cologne, Lindenburger Allee 42, 50931, Cologne, Germany.
[Ti] Título:Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trial.
[So] Source:Eur Arch Otorhinolaryngol;273(9):2591-7, 2016 Sep.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of this observational trial was to evaluate the efficacy and tolerability of a mouth and throat spray containing ectoine in the treatment of acute pharyngitis and/or laryngitis. The outcome was compared with control treatment using saline lozenges. This study was designed as a prospective, controlled, non-randomized, observational multicenter clinical trial and was conducted in Germany. The study population consisted of 95 patients. The decision for treatment with either spray or lozenges was based on the patients' preference for pharyngeal or oral application. Investigators assessed symptoms specific to acute pharyngitis/laryngitis and determined the pharyngitis symptom score. Both patients and investigators evaluated the tolerability and efficacy of the treatment applied. Treatment with the spray showed higher efficacy, 1.95 ± 0.81 versus 1.68 ± 0.67 (investigators) and 1.97 ± 0.88 versus 1.57 ± 0.69 (patients, p < 0.05). Treatment with the spray resulted in significantly greater reduction of cervical lymph node swelling (p < 0.05), ∆ spray = 0.44 ± 0.62, ∆ lozenges = 0.21 ± 0.62. The lozenges showed some advantage in relieving cough, ∆ lozenges = 0.62 ± 0.94 versus ∆ spray = 0.44 ± 0.85. Both patients and investigators rated the tolerability of both medical devices as "good" to "very good". Adverse events of mild to moderate severity were either possibly related or not related to the medical devices used. No serious adverse events occurred. Taken together, while the tolerability was consistent in both treatment groups, the ectoine-based spray showed superior efficacy in treating acute pharyngitis and/or laryngitis.
[Mh] Termos MeSH primário: Diamino Aminoácidos/uso terapêutico
Laringite/tratamento farmacológico
Faringite/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Idoso
Feminino
Alemanha
Seres Humanos
Masculino
Meia-Idade
Sprays Orais
Estudos Prospectivos
Cloreto de Sódio
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Amino Acids, Diamino); 0 (Oral Sprays); 451W47IQ8X (Sodium Chloride); 7GXZ3858RY (ectoine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160430
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-016-4060-z



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