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[PMID]: 28938140 [Au] Autor: Yi X; He J; Guo Y; Han Z; Yang M; Jin J; Gu J; Ou M; Xu X [Ad] Endereço: College of Chemistry, Fuzhou University, Fuzhou 350108, China. Electronic address: 927208329@qq.com. [Ti] Título: Encapsulating Fe O into calcium alginate coated chitosan hydrochloride hydrogel beads for removal of Cu (II) and U (VI) from aqueous solutions. [So] Source: Ecotoxicol Environ Saf;147:699-707, 2018 Jan. [Is] ISSN: 1090-2414 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The aim of this work was to study the removal of Cu (II) and U (VI) ions from aqueous solutions by encapsulating magnetic Fe O nanoparticles into calcium alginate coated chitosan hydrochloride (CCM) hydrogel beads. ATR-FTIR and XRD analysis data indicated that the CCM composites were successfully prepared. SEM images and EDX spectra showed that Cu and UO ions were adhered onto sorbents. Adsorption properties for removal of both copper and uranium ions under various experimental conditions were investigated. Kinetic data and sorption equilibrium isotherms were also conducted in batch process. The sorption kinetic analysis revealed that sorption of Cu (II) and U (VI) followed the pseudo-second-order model well and exhibited 3-stage intraparticle diffusion model during the whole sorption process. Equilibrium data were best described by Langmuir model, and the CCM composite hydrogel beads showed the estimated maximum adsorption capacity 143.276mg/g and 392.692mg/g for Cu (II) and U (VI), respectively. The CCM adsorbent exhibited excellent reusability for five cycles use without significant changes in the adsorption capacity and structural stability. The results demonstrated that CCM can be an effective and promising sorbent for Cu (II) and U (VI) ions in wastewater. [Mh] Termos MeSH primário: Alginatos/química Quitosana/química Cobre/análise Nanopartículas de Magnetita/química Compostos de Urânio/análise Poluentes Químicos da Água/análise Purificação da Água/métodos [Mh] Termos MeSH secundário: Adsorção Ácido Glucurônico/química Ácidos Hexurônicos/química Hidrogéis/química Concentração de Íons de Hidrogênio Íons Cinética Modelos Teóricos Soluções [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Alginates); 0 (Hexuronic Acids); 0 (Hydrogels); 0 (Ions); 0 (Magnetite Nanoparticles); 0 (Solutions); 0 (Uranium Compounds); 0 (Water Pollutants, Chemical); 789U1901C5 (Copper); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); 9012-76-4 (Chitosan) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170923 [St] Status: MEDLINE

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[PMID]: 28450244 [Au] Autor: El-Naggar AWM; Senna MM; Mostafa TA; Helal RH [Ad] Endereço: Radiation Chemistry Department, National Center for Radiation Research and Technology, Nasr City, Atomic Energy Authority, Cairo, Egypt. Electronic address: ab_nagga@yahoo.com. [Ti] Título: Radiation synthesis and drug delivery properties of interpenetrating networks (IPNs) based on poly(vinyl alcohol)/ methylcellulose blend hydrogels. [So] Source: Int J Biol Macromol;102:1045-1051, 2017 Sep. [Is] ISSN: 1879-0003 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Gamma radiation was used to prepare blend hydrogels from poly(vinyl alcohol) (PVA) and low ratios of methylcellulose (MC). The structure-property behavior was characterized by IR spectroscopy, gel fraction, differential scanning calorimetry (DSC) and swelling at room temperature and different pH values. The PVA/MC hydrogels were used as a carrier for doxycycline hyclate (DOX-h) drug. The results showed that the gel fraction of PVA/MC hydrogels decreased greatly with increasing the ratio of MC in the initial feeding solution. The PVA/MC hydrogels displayed pH-sensitive swelling character. The drug uptake-release study indicated that PVA/MC hydrogels possessed controlled release behavior and that the release process depends on pH. In this respect, the release of DOX-h drug was significant in alkaline medium. [Mh] Termos MeSH primário: Portadores de Fármacos/química Portadores de Fármacos/síntese química Hidrogéis/química Hidrogéis/síntese química Metilcelulose/química Álcool de Polivinil/química [Mh] Termos MeSH secundário: Técnicas de Química Sintética Doxiciclina/química Liberação Controlada de Fármacos Raios gama Concentração de Íons de Hidrogênio Radioquímica [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drug Carriers); 0 (Hydrogels); 9002-89-5 (Polyvinyl Alcohol); 9004-67-5 (Methylcellulose); N12000U13O (Doxycycline) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 27775923 [Au] Autor: Ortuño-Lizarán I; Vilariño-Feltrer G; Martínez-Ramos C; Pradas MM; Vallés-Lluch A [Ad] Endereço: Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Cno. de Vera s/n, E-46022, Valencia, Spain. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain. [Ti] Título: Influence of synthesis parameters on hyaluronic acid hydrogels intended as nerve conduits. [So] Source: Biofabrication;8(4):045011, 2016 10 24. [Is] ISSN: 1758-5090 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Hydrogels have widely been proposed lately as strategies for neural tissue regeneration, but there are still some issues to be solved before their efficient use in tissue engineering of trauma, stroke or the idiopathic degeneration of the nervous system. In a previous work of the authors a novel Schwann-cell structure with the shape of a hollow cylinder was obtained using a three-dimensional conduit based in crosslinked hyaluronic acid as template. This original engineered tissue of tightly joined Schwann cells obtained in a conduit lumen having 400 µm in diameter is a consequence of specific cell-material interactions. In the present work we analyze the influence of the hydrogel concentration and of the drying process on the physicochemical and biological performance of the resulting tubular scaffolds, and prove that the cylinder-like cell sheath obtains also in scaffolds of a larger inner diameter. The diffusion of glucose and of the protein BSA through the scaffolds is studied and characterized, as well as the enzymatic degradation kinetics of the lyophilized conduits. This can be modulated from a couple of weeks to several months by varying the concentration of hyaluronic acid in the starting solution. These findings allow to improve the performance of hyaluronan intended for neural conduits, and open the way to scaffolds with tunable degradation rate adapted to the site and severity of the injury. [Mh] Termos MeSH primário: Ácido Hialurônico/química Hidrogéis/química Tecidos Suporte/química [Mh] Termos MeSH secundário: Animais Bovinos Linhagem Celular Proliferação Celular Sobrevivência Celular Difusão Glucose/metabolismo Hidrogéis/síntese química Regeneração Nervosa Porosidade Ratos Células de Schwann/citologia Células de Schwann/metabolismo Células de Schwann/patologia Soroalbumina Bovina/metabolismo Engenharia Tecidual [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Hydrogels); 27432CM55Q (Serum Albumin, Bovine); 9004-61-9 (Hyaluronic Acid); IY9XDZ35W2 (Glucose) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 28747396 [Au] Autor: Vernerey F; Shen T [Ad] Endereço: Mechanical Engineering, University of Colorado Boulder, 427 UCB, Boulder, CO, USA franck.vernerey@colorado.edu. [Ti] Título: The mechanics of hydrogel crawlers in confined environment. [So] Source: J R Soc Interface;14(132), 2017 Jul. [Is] ISSN: 1742-5662 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: We present theoretical and experimental results regarding the development of temperature-sensitive hydrogel particles that can display self-motility in confined channels. Inspired by the motility of living organisms such as larva, the motion of the particle relies on the combination of two key mechanisms. The first, referred to as actuation, is enabled by the cyclic extension and retraction of the particle owing to oscillations of its temperature around the so-called lower critical solution temperature. The second, referred to as symmetry breaking, transforms the isotropic particle actuation into a directed motion owing to the asymmetric friction properties of the channel's surface. The role of particle confinement in these processes is, however, less intuitive and displays an optimal value at which the particle's step size is maximum. These observations are supported by a model that identifies the underlying locomotion mechanisms and predicts the dependency of the particle motion efficiency on the confinement condition, as well as frictional properties of the substrate. Our analysis suggests that the existence of a lubrication layer around the particle hinders its motion at low confinement, while an excessive degree of confinement is detrimental to the particle's overall deformation and, thus, to its locomotion efficiency. [Mh] Termos MeSH primário: Hidrogéis Fenômenos Mecânicos Modelos Teóricos Movimento [Mh] Termos MeSH secundário: Animais Insetos/fisiologia Larva/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hydrogels) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180228 [Lr] Data última revisão: 180228 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170728 [St] Status: MEDLINE

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[PMID]: 27770562 [Au] Autor: Wang C; Tong X; Jiang X; Yang F [Ad] Endereço: Department of Bioengineering, Stanford University, Stanford, California, 94305. [Ti] Título: Effect of matrix metalloproteinase-mediated matrix degradation on glioblastoma cell behavior in 3D PEG-based hydrogels. [So] Source: J Biomed Mater Res A;105(3):770-778, 2017 03. [Is] ISSN: 1552-4965 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with median survival of 12 months. To improve clinical outcomes, it is critical to develop in vitro models that support GBM proliferation and invasion for deciphering tumor progression and screening drug candidates. A key hallmark of GBM cells is their extreme invasiveness, a process mediated by matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix. We recently reported the development of a MMP-degradable, poly(ethylene-glycol)-based hydrogel platform for culturing GBM cells. In the present study, we modulated the percentage of MMP-degradable crosslinks in 3D hydrogels to analyze the effects of MMP-degradability on GBM fates. Using an immortalized GBM cell line (U87) as a model cell type, our results showed that MMP-degradability was not required for supporting GBM proliferation. All hydrogel formulations supported robust GBM proliferation, up to 10 fold after 14 days. However, MMP-degradability was essential for facilitating tumor spreading, and 50% MMP-degradable hydrogels were sufficient to enable both robust tumor cell proliferation and spreading in 3D. The findings of this study highlight the importance of modulating MMP-degradability in engineering 3D in vitro brain cancer models and may be applied for engineering in vitro models for other cancer types. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 770-778, 2017. [Mh] Termos MeSH primário: Neoplasias Encefálicas/metabolismo Matriz Extracelular/química Glioblastoma/metabolismo Hidrogéis/química Polietilenoglicóis/química [Mh] Termos MeSH secundário: Neoplasias Encefálicas/patologia Linhagem Celular Tumoral Gelatinases Glioblastoma/patologia Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nome de substância: 0 (Hydrogels); 30IQX730WE (Polyethylene Glycols); EC 3.4.24.- (Gelatinases); U076Q6Q621 (polyethylene glycol 1000) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161023 [St] Status: MEDLINE [do] DOI: 10.1002/jbm.a.35947

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[PMID]: 29343687 [Au] Autor: Frith JE; Kusuma GD; Carthew J; Li F; Cloonan N; Gomez GA; Cooper-White JJ [Ad] Endereço: Materials Science and Engineering, Monash University, Clayton, VIC, 3800, Australia. Jessica.Frith@monash.edu. [Ti] Título: Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling. [So] Source: Nat Commun;9(1):257, 2018 01 17. [Is] ISSN: 2041-1723 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation, migration and differentiation. However, when incorporating MSCs within injectable, inherently soft hydrogels, this dominance over MSC response substantially limits our ability to couple the ease of application of hydrogels with efficiently directed MSC differentiation, especially in the case of bone generation. Here, we identify differential miRNA expression in response to varying hydrogel stiffness and RhoA activity. We show that modulation of miR-100-5p and miR-143-3p can be used to bias MSC fate and provide mechanistic insight by demonstrating convergence on mTOR signalling. By modulating these mechanosensitive miRNAs, we can enhance osteogenesis in a soft 3D hydrogel. The outcomes of this study provide new understanding of the mechanisms regulating MSC mechanotransduction and differentiation, but also a novel strategy with which to drive MSC fate and significantly impact MSC-based tissue-engineering applications. [Mh] Termos MeSH primário: Diferenciação Celular/genética Proliferação Celular/genética Células Mesenquimais Estromais/metabolismo MicroRNAs/genética [Mh] Termos MeSH secundário: Células Cultivadas Regulação da Expressão Gênica Seres Humanos Hidrogéis/metabolismo Mecanotransdução Celular Células Mesenquimais Estromais/citologia Microscopia Confocal Osteogênese/genética Transdução de Sinais/genética Serina-Treonina Quinases TOR/genética Serina-Treonina Quinases TOR/metabolismo Engenharia Tecidual/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Hydrogels); 0 (MicroRNAs); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180119 [St] Status: MEDLINE [do] DOI: 10.1038/s41467-017-02486-0

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[PMID]: 29329332 [Au] Autor: Goldman SM; Henderson BEP; Walters TJ; Corona BT [Ad] Endereço: United States Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas, United States of America. [Ti] Título: Co-delivery of a laminin-111 supplemented hyaluronic acid based hydrogel with minced muscle graft in the treatment of volumetric muscle loss injury. [So] Source: PLoS One;13(1):e0191245, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Minced muscle autografting mediates de novo myofiber regeneration and promotes partial recovery of neuromuscular strength after volumetric muscle loss injury (VML). A major limitation of this approach is the availability of sufficient donor tissue for the treatment of relatively large VMLs without inducing donor site morbidity. This study evaluated a laminin-111 supplemented hyaluronic acid based hydrogel (HA+LMN) as a putative myoconductive scaffolding to be co-delivered with minced muscle grafts. In a rat tibialis anterior muscle VML model, delivery of a reduced dose of minced muscle graft (50% of VML defect) within HA+LMN resulted in a 42% improvement of peak tetanic torque production over unrepaired VML affected limbs. However, the improvement in strength was not improved compared to a 50% minced graft-only control group. Moreover, histological analysis revealed that the improvement in in vivo functional capacity mediated by minced grafts in HA+LMN was not accompanied by a particularly robust graft mediated regenerative response as determined through donor cell tracking of the GFP+ grafting material. Characterization of the spatial distribution and density of macrophage and satellite cell populations indicated that the combination therapy damps the heightened macrophage response while re-establishing satellite content 14 days after VML to a level consistent with an endogenously healing ischemia-reperfusion induced muscle injury. Moreover, regional analysis revealed that the combination therapy increased satellite cell density mostly in the remaining musculature, as opposed to the defect area. Based on the results, the following salient conclusions were drawn: 1) functional recovery mediated by the combination therapy is likely due to a superposition of de novo muscle fiber regeneration and augmented repair of muscle fibers within the remaining musculature, and 2) The capacity for VML therapies to augment regeneration and repair within the remaining musculature may have significant clinical impact and warrants further exploration. [Mh] Termos MeSH primário: Ácido Hialurônico/administração & dosagem Laminina/administração & dosagem Músculo Esquelético/lesões Músculo Esquelético/transplante [Mh] Termos MeSH secundário: Animais Modelos Animais de Doenças Hidrogéis Masculino Força Muscular Músculo Esquelético/fisiologia Isoformas de Proteínas/administração & dosagem Ratos Ratos Endogâmicos Lew Regeneração/efeitos dos fármacos Regeneração/fisiologia Traumatismo por Reperfusão/terapia Tecidos Suporte/química Transplante Autólogo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Hydrogels); 0 (Laminin); 0 (Protein Isoforms); 9004-61-9 (Hyaluronic Acid) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180113 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191245

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[PMID]: 29323684 [Au] Autor: Pérez-Mas L; Martín-Molina A; Quesada-Pérez M; Moncho-Jordá A [Ad] Endereço: Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Granada, Avenida Fuentenueva S/N, 18001 Granada, Spain. [Ti] Título: Maximizing the absorption of small cosolutes inside neutral hydrogels: steric exclusion versus hydrophobic adhesion. [So] Source: Phys Chem Chem Phys;20(4):2814-2825, 2018 Jan 24. [Is] ISSN: 1463-9084 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: In this work the equilibrium absorption of nanometric cosolutes (which could represent drugs, reactants, small globular proteins and other kind of biomacromolecules) inside neutral hydrogels is studied. We specially focus on exploring, for different swelling states, the competition between the steric exclusion induced by the cross-linked polymer network constituting the hydrogel, and the solvent-induced short-range hydrophobic attraction between the polymer chains and the cosolute particle. For this purpose, the cosolute partition coefficient is calculated by means of coarse-grained grand canonical Monte Carlo simulations, and the results are compared to theoretical predictions based on the calculation of the excluded and binding volume around the polymer chains. For small hydrophobic attractions or large cosolute sizes, the steric repulsion dominates, and the partition coefficient decreases monotonically with the polymer volume fraction, Ï• . However, for large enough hydrophobic attraction strength, the interplay between hydrophobic adhesion and the steric exclusion leads to a maximum in the partition coefficient at certain intermediate polymer density. Good qualitative and quantitative agreement is achieved between simulation results and theoretical predictions in the limit of small Ï• , pointing out the importance of geometrical aspects of the cross-linked polymer network, even for hydrogels in the swollen state. In addition, the theory is able to predict analytically the onset of the maximum formation in terms of the details of the cosolute-monomer pair interaction, in good agreement with simulations too. Finally, the effect of the many-body attractions between the cosolute and multiple polymer chains is quantified. The results clearly show that these many-body attractions play a very relevant role determining the cosolute binding, enhancing its absorption in more than one order of magnitude. [Mh] Termos MeSH primário: Hidrogéis/química [Mh] Termos MeSH secundário: Interações Hidrofóbicas e Hidrofílicas Método de Monte Carlo Polímeros/química Solventes/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hydrogels); 0 (Polymers); 0 (Solvents) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180112 [St] Status: MEDLINE [do] DOI: 10.1039/c7cp07679g

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[PMID]: 28457187 [Au] Autor: Munarin F; Kaiser NJ; Kim TY; Choi BR; Coulombe KLK [Ad] Endereço: 1 School of Engineering, Brown University , Providence, Rhode Island. [Ti] Título: Laser-Etched Designs for Molding Hydrogel-Based Engineered Tissues. [So] Source: Tissue Eng Part C Methods;23(5):311-321, 2017 05. [Is] ISSN: 1937-3392 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Rapid prototyping and fabrication of elastomeric molds for sterile culture of engineered tissues allow for the development of tissue geometries that can be tailored to different in vitro applications and customized as implantable scaffolds for regenerative medicine. Commercially available molds offer minimal capabilities for adaptation to unique conditions or applications versus those for which they are specifically designed. Here we describe a replica molding method for the design and fabrication of poly(dimethylsiloxane) (PDMS) molds from laser-etched acrylic negative masters with ∼0.2 mm resolution. Examples of the variety of mold shapes, sizes, and patterns obtained from laser-etched designs are provided. We use the patterned PDMS molds for producing and culturing engineered cardiac tissues with cardiomyocytes derived from human-induced pluripotent stem cells. We demonstrate that tight control over tissue morphology and anisotropy results in modulation of cell alignment and tissue-level conduction properties, including the appearance and elimination of reentrant arrhythmias, or circular electrical activation patterns. Techniques for handling engineered cardiac tissues during implantation in vivo in a rat model of myocardial infarction have been developed and are presented herein to facilitate development and adoption of surgical techniques for use with hydrogel-based engineered tissues. In summary, the method presented herein for engineered tissue mold generation is straightforward and low cost, enabling rapid design iteration and adaptation to a variety of applications in tissue engineering. Furthermore, the burden of equipment and expertise is low, allowing the technique to be accessible to all. [Mh] Termos MeSH primário: Hidrogéis/química Lasers Infarto do Miocárdio/terapia Miócitos Cardíacos/citologia Engenharia Tecidual/métodos [Mh] Termos MeSH secundário: Animais Animais Recém-Nascidos Células Cultivadas Elasticidade Seres Humanos Masculino Miócitos Cardíacos/fisiologia Ratos Ratos Sprague-Dawley [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hydrogels) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE [do] DOI: 10.1089/ten.TEC.2017.0068

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[PMID]: 29222859 [Au] Autor: Tyliszczak B; Drabczyk A; Kudlacik-Kramarczyk S; Grabowska B; Kedzierska M [Ad] Endereço: Department of Chemistry and Technology of Polymers, Cracow University of Technology, Kraków, Poland. [Ti] Título: Physicochemical properties and cytotoxicity of hydrogels based on Beetosan® containing sage and bee pollen. [So] Source: Acta Biochim Pol;64(4):709-712, 2017. [Is] ISSN: 1734-154X [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: Currently, increasing attention is being paid to issues related to environmental protection, waste management, as well as to the development of polymers with useful properties. The research presented here involved preparation of hydrogels based on Beetosan® - a chitosan derived from the multi-stage processing of dead bees. Moreover, hydrogels were additionally modified with natural substances - i.e. bee pollen and extract of Salvia officinalis (sage) that are well known for the presence of many compounds with beneficial properties from a medical point of view. Materials have been first obtained by photopolymerization. Then, their surface morphology, wettability and cytotoxicity to selected cell lines have been determined. It can be stated that such combination of Beetosan® hydrogel matrix and the mentioned additives resulted in a preparation of polymers characterized by negative impact on cancer cells. Impact of hydrogels with sage is slightly more intense due to the presence of substances such as ursalic or rosmaric acid that are characterized to have anticancer activity. Such negative impact has not been observed in case of studies using fibroblasts. Furthermore, addition of natural substances into hydrogels resulted in a more homogeneous surface and in the decrease of wettability angle of the tested polymers. It can be concluded that the use of natural-derived reagents and synthesis of polymers using these reagents (as a result of environmentally friendly photopolymerization) yields materials with interesting properties for medical purposes, with particular emphasis on antitumor activity, and without significant negative impact on fibroblasts. [Mh] Termos MeSH primário: Hidrogéis/química Hidrogéis/toxicidade Pólen/química [Mh] Termos MeSH secundário: Animais Abelhas Quitosana/química Seres Humanos Células Jurkat Microscopia Eletrônica de Varredura Salvia officinalis Testes de Toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hydrogels); 9012-76-4 (Chitosan) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180223 [Lr] Data última revisão: 180223 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171210 [St] Status: MEDLINE [do] DOI: 10.18388/abp.2017_2319

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