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Pesquisa : D20.633.937 [Categoria DeCS]
Referências encontradas : 6816 [refinar]
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  1 / 6816 MEDLINE  
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[PMID]:29381718
[Au] Autor:Sasaki M; Chubachi S; Kameyama N; Sato M; Haraguchi M; Miyazaki M; Takahashi S; Nakano T; Kuroda Y; Betsuyaku T; Matsuo K
[Ad] Endereço:Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan.
[Ti] Título:Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema.
[So] Source:PLoS One;13(1):e0191611, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema is a risk factor for vertebral fracture; however, the effects of smoking or emphysema on bone health remain largely unknown. We report bone deterioration in a mouse model of emphysema induced by nose-only cigarette smoke (CS) exposure. Unexpectedly, short-term exposure for 4-weeks decreased bone turnover and increased bone volume in mice. However, prolonged exposure for 20- and 40-weeks reversed the effects from suppression to promotion of bone resorption. This long-term CS exposure increased osteoclast number and impaired bone growth, while it increased bone volume. Strikingly, long-term CS exposure deteriorated bone quality of the lumbar vertebrae as illustrated by disorientation of collagen fibers and the biological apatite c-axis. This animal model may provide a better understanding of the mechanisms underlying the deterioration of bone quality in pulmonary emphysema caused by smoking.
[Mh] Termos MeSH primário: Osso e Ossos/metabolismo
Modelos Animais de Doenças
Enfisema/metabolismo
Fumaça
Produtos do Tabaco
[Mh] Termos MeSH secundário: Animais
Remodelação Óssea
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191611


  2 / 6816 MEDLINE  
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[PMID]:28467206
[Au] Autor:Brickle MB; Evans-Agnew R
[Ad] Endereço:a University of Washington , Tacoma , Washington.
[Ti] Título:Photovoice and Youth Empowerment in Environmental Justice Research: A Pilot Study Examining Woodsmoke Pollution in a Pacific Northwest Community.
[So] Source:J Community Health Nurs;34(2):89-101, 2017 Apr-Jun.
[Is] ISSN:1532-7655
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Woodsmoke pollution is an environmental justice issue for youth living in certain Pacific Northwest cities. Participatory methods such as Citizen Science and Photovoice are effective ways to involve youth in environmental justice research. Little is understood about how youth may be empowered to address woodsmoke issues in their communities. We examined youth empowerment in a citizen science study on woodsmoke, using Photovoice methodology. Ten diverse youth collected and analyzed indoor air samples and photos, then presented their findings to the community and policy makers. Entrance and exit surveys revealed an increased sense of empowerment to take action on woodsmoke pollution. Youth also expressed increased optimism and a resolve to become scientists to combat environmental injustices.
[Mh] Termos MeSH primário: Poluição do Ar/prevenção & controle
Pesquisa Participativa Baseada na Comunidade/métodos
Poder (Psicologia)
Fumaça/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Meio Ambiente
Feminino
Seres Humanos
Masculino
Fotografia
Projetos Piloto
Fumaça/efeitos adversos
Justiça Social
Washington
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1080/07370016.2017.1304148


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[PMID]:29292978
[Au] Autor:Palm A; Wilander E; Wallgren S; Hillerdal G
[Ad] Endereço:Department of Medical Sciences, Respiratory, Allergy and Sleep Research - Uppsala, Sweden Department of Medical Sciences, Respiratory, Allergy and Sleep Research - Uppsala, Sweden.
[Ti] Título:Sotrökslunga är en ny sjukdom i Sverige - Exponering för rök från biomassa är orsaken..
[So] Source:Lakartidningen;114, 2017 Dec 18.
[Is] ISSN:1652-7518
[Cp] País de publicação:Sweden
[La] Idioma:swe
[Ab] Resumo:Black smoke lung disease - a new disease in Sweden We describe two elderly female patients, immigrants to Sweden from Afghanistan, with intensive longtime exposure to smoke from biomass, and who presented with bronchial stenosis and severe bronchial obstruction. CT and X-ray showed bizarre perihilar infiltrates in the lungs. Bronchoscopy revealed black narrow bronchi with a middle lobe stenosis in one of the patients. These findings indicate the diagnosis bronchial anthracofibrosis (BAF). The here described findings are seen mainly in elderly never-smoking women from developing countries who have spent years cooking food in poorly ventilated kitchens. With increased immigration from these countries such cases will be seen in industrialized countries as well. Active tuberculosis must always be excluded but otherwise no more active investigations such as biopsies are warranted. We suggest that this disease should be termed ¼black smoke disease« to differentiate it from coal workers' pneumoconiosis, silicosis, and other classical occupational diseases which can have similar clinical and radiological pictures. This term is easily understood even by non-medical persons and illustratess both the etiology and the black bronchi.
[Mh] Termos MeSH primário: Antracose
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Afeganistão/etnologia
Antracose/diagnóstico
Antracose/diagnóstico por imagem
Antracose/etiologia
Antracose/patologia
Biomassa
Broncoscopia
Materiais de Construção/efeitos adversos
Feminino
Seres Humanos
Irã (Geográfico)/etnologia
Meia-Idade
Exposição Ocupacional/efeitos adversos
Radiografia
Suécia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


  4 / 6816 MEDLINE  
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[PMID]:28470140
[Au] Autor:Carson JL; Zhou L; Brighton L; Mills KH; Zhou H; Jaspers I; Hazucha M
[Ad] Endereço:a The Center for Environmental Medicine, Asthma, and Lung Biology , The University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
[Ti] Título:Temporal structure/function variation in cultured differentiated human nasal epithelium associated with acute single exposure to tobacco smoke or E-cigarette vapor.
[So] Source:Inhal Toxicol;29(3):137-144, 2017 02.
[Is] ISSN:1091-7691
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Mucociliary clearance sustains a baseline functionality and an "on demand" capability to upregulate clearance upon irritant exposure involving mucus hypersecretion and accelerated ciliary beat frequency (CBF) modulated by nitric oxide (NO). This study characterized these elements as well as cellular and exogenous NO concentrations subsequent to a single exposure to tobacco smoke (TS) or e-cigarette vapor (EV) on cultured human airway epithelium. MATERIALS AND METHODS: Air-liquid interface (ALI) airway epithelial cultures per nonsmoking human subjects were subjected to single TS or EV exposures. Measures of ciliary function and secretion were performed and cellular and exogenous NO concentrations under control and experimental conditions were assessed. RESULTS: Both TS and EV exposures resulted similar patterns of decline in CBF within 1 min of the completion of exposure followed by a gradual return often exceeding baseline within 1 h. Post-exposure examination of exposed cultures suggested morphologic differences in secretory function relative to controls. The relative NO concentrations of TS and EV chamber air were sharply different with EV NO being only slightly elevated relative to cellular NO production. DISCUSSION AND CONCLUSIONS: Epithelial remodeling and mucociliary dysfunction have been clearly associated with TS exposure. However, information contrasting epithelial structure/function following a single acute TS or EV exposure is limited. This study demonstrates a similar pattern of epithelial response to acute TS or EV exposure. Inasmuch as NO may contribute to an inflammatory milieu and generation of toxic metabolites, it is plausible that recurrent exposures over time may be contributory to chronic pathologies.
[Mh] Termos MeSH primário: Sistemas Eletrônicos de Liberação de Nicotina
Mucosa Nasal/efeitos dos fármacos
Fumaça/efeitos adversos
Tabaco
[Mh] Termos MeSH secundário: Diferenciação Celular
Células Cultivadas
Cílios/efeitos dos fármacos
Cílios/fisiologia
Seres Humanos
Microscopia Eletrônica de Varredura
Depuração Mucociliar
Mucosa Nasal/citologia
Mucosa Nasal/metabolismo
Mucosa Nasal/ultraestrutura
Óxido Nítrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Smoke); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1080/08958378.2017.1318985


  5 / 6816 MEDLINE  
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[PMID]:28470141
[Au] Autor:Leslie LJ; Vasanthi Bathrinarayanan P; Jackson P; Mabiala Ma Muanda JA; Pallett R; Stillman CJP; Marshall LJ
[Ad] Endereço:a School of Engineering and Applied Science , Aston University , Birmingham , UK.
[Ti] Título:A comparative study of electronic cigarette vapor extracts on airway-related cell lines in vitro.
[So] Source:Inhal Toxicol;29(3):126-136, 2017 02.
[Is] ISSN:1091-7691
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The use of electronic cigarettes (ECs) is rapidly increasing worldwide; however, scientific evidence regarding EC cytotoxicity is limited. The aim of this study was to evaluate the acute cytotoxicity of EC vapor extract (ECE) on airway-related cells in vitro. Cigarette smoke extract (CSE), vapor extract of fifteen brands/flavors of ECs and the extract from the E-vehicle (propylene glycol and glycerin) was collected. Extracts, in concentrations of 100-12.5%, were added to human bronchial epithelial (BEAS-2B, IB3-1 and C38), fibroblast (Wi-38) and macrophage (J774 and THP-1) cell lines. Viability was assessed after 24 h using a standard XTT assay. Viability of <70% of control (no extract) was considered cytotoxic according to UNI EN ISO 10993-5 standards. CSE displayed a concentration-dependent influence on cell viability across all four cell lines with 100% producing the most toxic effect, therefore validating the model and indicating higher cytotoxicity than in ECEs. ECEs did reduce viability although this was not correlated with nicotine content or the E-vehicle. However, several flavors proved cytotoxic, with variation between different brands and cell lines. These data indicate that not all ECs are the same and that use of a particular flavor or brand may have differing effects. The cell line used is also an important factor. More research is crucial to ascertain the health effects of different ECs before they can be accepted as a safe alternative to tobacco cigarettes.
[Mh] Termos MeSH primário: Misturas Complexas/toxicidade
Sistemas Eletrônicos de Liberação de Nicotina
Aromatizantes/toxicidade
Fumaça
[Mh] Termos MeSH secundário: Brônquios/citologia
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Macrófagos/efeitos dos fármacos
Nicotina/toxicidade
Tabaco
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Complex Mixtures); 0 (Flavoring Agents); 0 (Smoke); 6M3C89ZY6R (Nicotine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1080/08958378.2017.1318193


  6 / 6816 MEDLINE  
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[PMID]:29388831
[Au] Autor:Radder JE; Shapiro SD
[Ad] Endereço:1 University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.
[Ti] Título:Reply to: Quantitative Histology Seriously Flawed by Lack of Lung Volume Measurement.
[So] Source:Am J Respir Cell Mol Biol;58(2):274-275, 2018 02.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fumar Cigarros/efeitos adversos
Medidas de Volume Pulmonar
Pulmão/fisiologia
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Pulmão/anatomia & histologia
Camundongos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2017-0394LE


  7 / 6816 MEDLINE  
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[PMID]:29388832
[Au] Autor:Mitzner W; Ochs M
[Ad] Endereço:1 Johns Hopkins Bloomberg School of Public Health Baltimore, Maryland and.
[Ti] Título:Quantitative Histology Seriously Flawed by Lack of Lung Volume Measurement.
[So] Source:Am J Respir Cell Mol Biol;58(2):273-274, 2018 02.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fumar Cigarros/efeitos adversos
Medidas de Volume Pulmonar
Pulmão/fisiologia
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Pulmão/anatomia & histologia
Camundongos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2017-0380LE


  8 / 6816 MEDLINE  
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[PMID]:29377962
[Au] Autor:Nwankwo ONO; Mokogwu N; Agboghoroma O; Ahmed FO; Mortimer K
[Ad] Endereço:Department of Community Medicine, University of Calabar Teaching Hospital, Calabar, Nigeria.
[Ti] Título:Knowledge, attitudes and beliefs about the health hazards of biomass smoke exposure amongst commercial food vendors in Nigeria.
[So] Source:PLoS One;13(1):e0191458, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Exposure to biomass smoke is a major cause of morbidity and mortality in Africa. Commercial food vendors in Nigeria and elsewhere in Africa are commonly exposed to biomass smoke from open fire cooking both at work and home. Little is known about the knowledge, attitudes and beliefs of food vendors about the health hazards of biomass smoke exposure in Nigeria. METHODS: We did a descriptive cross sectional survey of the knowledge, attitudes and beliefs of commercial food vendors in the cities of Benin and Calabar in Nigeria. We recruited respondents using a multi-stage approach. Structured interviewer-administered questionnaires were used for data collection. RESULTS: We recruited 308 participants (164, 53.2% female). The majority 185(60.2%) were married and had post-primary education 206(67.4%). The average monthly income was <30,000 Naira (US$150). Most 198(64.4%) were not aware that biomass smoke exposure is harmful to human health. About three-quarters (221; 71.8%) were unconcerned as to the effect of exposure to fumes from biomass fuels on their health. Less than half of respondents (110, 41.6%) believed biomass smoke was harmful to health. Male gender, being single, having post-primary education and preferring electricity or gas fuels were associated with good knowledge of the adverse health effects of biomass smoke exposure whilst female gender and having good knowledge of the adverse health effects of biomass smoke were associated with positive attitudes towards preventing exposure. CONCLUSION: Commercial food vendors in our study had limited knowledge about the adverse health effects of biomass smoke exposure and negative attitudes towards preventing these adverse health effects. We suggest an educational intervention is needed to improve this knowledge.
[Mh] Termos MeSH primário: Biomassa
Comércio/estatística & dados numéricos
Culinária/economia
Conhecimentos, Atitudes e Prática em Saúde
Exposição Ocupacional/efeitos adversos
Fumaça/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Nigéria
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191458


  9 / 6816 MEDLINE  
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[PMID]:28468623
[Au] Autor:Murray LA; Dunmore R; Camelo A; Da Silva CA; Gustavsson MJ; Habiel DM; Hackett TL; Hogaboam CM; Sleeman MA; Knight DA
[Ad] Endereço:Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Cambridge, CB21 6GH, United Kingdom. murrayl@medimmune.com.
[Ti] Título:Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium.
[So] Source:Respir Res;18(1):82, 2017 May 03.
[Is] ISSN:1465-993X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In these conditions, disease progression is associated with epithelial damage and fragility, airway remodelling and sub-epithelial fibrosis. The aim of this study was to assess the acute effects of cigarette smoke on epithelial cell phenotype and pro-fibrotic responses in vitro and in vivo. RESULTS: Apoptosis was significantly greater in unstimulated cells from COPD patients compared to control, but proliferation and CXCL8 release were not different. Cigarette smoke dose-dependently induced apoptosis, proliferation and CXCL8 release with normal epithelial cells being more responsive than COPD patient derived cells. Cigarette smoke did not induce epithelial-mesenchymal transition. In vivo, cigarette smoke exposure promoted epithelial apoptosis and proliferation. Moreover, mimicking a virus-induced exacerbation by exposing to mice to poly I:C, exaggerated the inflammatory responses, whereas expression of remodelling genes was similar in both. CONCLUSIONS: Collectively, these data indicate that cigarette smoke promotes epithelial cell activation and hyperplasia, but a secondary stimulus is required for the remodelling phenotype associated with COPD.
[Mh] Termos MeSH primário: Transição Epitelial-Mesenquimal/efeitos dos fármacos
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Fibrose Pulmonar/induzido quimicamente
Mucosa Respiratória/efeitos dos fármacos
Mucosa Respiratória/fisiopatologia
Fumaça/efeitos adversos
Produtos do Tabaco/envenenamento
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Doença Pulmonar Obstrutiva Crônica/induzido quimicamente
Doença Pulmonar Obstrutiva Crônica/patologia
Fibrose Pulmonar/patologia
Fibrose Pulmonar/fisiopatologia
Mucosa Respiratória/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Smoke)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s12931-017-0565-2


  10 / 6816 MEDLINE  
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[PMID]:29304131
[Au] Autor:Paul T; Salazar-Degracia A; Peinado VI; Tura-Ceide O; Blanco I; Barreiro E; Barberà JA
[Ad] Endereço:Department of Pulmonary Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
[Ti] Título:Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease.
[So] Source:PLoS One;13(1):e0190628, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development of emphysema and pulmonary vascular remodeling in animal models of chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the effects of sGC stimulation on oxidative stress in the plasma of guinea pigs chronically exposed to cigarette smoke (CS). METHODS AND RESULTS: Guinea pigs were exposed to CS or sham for three months, and received either the sGC stimulator BAY 41-2272 or vehicle. Body weight was measured weekly; and markers of oxidative stress in plasma, and airspace size and inflammatory cell infiltrate in lung tissue were analyzed at the end of the study. Compared to sham-exposed guinea pigs, CS-exposed animals gained less body weight and showed higher plasma levels of nitrated tyrosine residues (3-NT), 4-hydroxynonenal (4-HNE), and 8-hydroxydeoxyguanosine (8-OHdG). Treatment with the sGC stimulator led to a body weight gain in the CS-exposed guinea pigs similar to non-exposed and attenuated the increase in 3-NT and 4-HNE. Plasma levels of 3-NT correlated with the severity of inflammatory cell infiltrate in the lung. CONCLUSION: Stimulation of sGC prevents oxidative stress induced by CS exposure and is associated with an attenuated inflammatory response in the lung.
[Mh] Termos MeSH primário: Estresse Oxidativo
Doença Pulmonar Obstrutiva Crônica/metabolismo
Guanilil Ciclase Solúvel/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Fumar Cigarros
Ativação Enzimática
Cobaias
Pulmão/enzimologia
Pulmão/metabolismo
Masculino
Doença Pulmonar Obstrutiva Crônica/sangue
Doença Pulmonar Obstrutiva Crônica/enzimologia
Fumaça
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Biomarkers); 0 (Smoke); EC 4.6.1.2 (Soluble Guanylyl Cyclase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190628



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