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[PMID]:28454697
[Au] Autor:Tian FY; Hivert MF; Wen X; Xie C; Niu Z; Fan L; Gillman MW; Chen WQ
[Ad] Endereço:Department of Medical Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: tianfy@ma
[Ti] Título:Tissue differences in DNA methylation changes at AHRR in full term low birth weight in maternal blood, placenta and cord blood in Chinese.
[So] Source:Placenta;52:49-57, 2017 Apr.
[Is] ISSN:1532-3102
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Very few study addressed the relationship between Aryl-hydrocarbon receptor repressor (AHRR) DNA methylation and low birth weight, especially in multiple tissues of mother-infant pairs. In this study, we aimed to investigate AHRR DNA methylation modification in cord blood, placenta and maternal blood between full term low birth weight (FT-LBW) and full term normal birth weight (FT-NBW) newborns. METHODS: We enrolled 90 FT-LBW and 90 FT-NBW mother-infant pairs, of which all placenta and cord blood samples were collected while 45 maternal blood samples of each group were collected. We measured AHRR DNA methylation (Chr5: 373013-373606) using Sequenom MassARRAY, and assessed associations between AHRR DNA methylation and FT-LBW using logistic regression adjusting for maternal age, education, family income, delivery mode, and passive smoking. RESULTS: FT-LBW babies had 3% lower methylation at Chr5: 373378 (CpG 13) in cord blood, and 4-9% higher methylation levels at Chr5: 373315, 373378, 373423, 373476 and 373490/373494 (CpG 10; 13; 15; 16; 17/18 respectively) in maternal blood, comparing with FT-NBW. The methylation of Chr5: 373378 (CpG 13) remained significant association with FT-LBW both in cord blood (OR = 0.90; 95% CI: 0.82, 0.98) and maternal blood (OR = 1.14; 95% CI: 1.04, 1.25) further adjusting for each other in the same model. We observed no significant difference at any CpG sites in placenta. DISCUSSION: AHRR DNA methylation of cord and maternal blood might be independently associated with FT-LBW in different ways.
[Mh] Termos MeSH primário: Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo
Metilação de DNA
Sangue Fetal/metabolismo
Recém-Nascido de Baixo Peso/metabolismo
Placenta/metabolismo
Proteínas Repressoras/metabolismo
[Mh] Termos MeSH secundário: Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética
Estudos de Casos e Controles
China
Feminino
Seres Humanos
Recém-Nascido
Idade Materna
Gravidez
Proteínas Repressoras/genética
Poluição por Fumaça de Tabaco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AHRR protein, human); 0 (Basic Helix-Loop-Helix Transcription Factors); 0 (Repressor Proteins); 0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29412556
[Au] Autor:Levshin VF; Ladan BV; Slepchenko NI
[Ti] Título:[Research of the air environment in cafes and restaurants, where a nargile is smoked].
[So] Source:Gig Sanit;95(5):439-44, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:By means of special devices there was performed research of air in premises of 17 cafes and restaurants where nargile is smoking. In the premises during the day and more there was evaluated a concentration of the following markers of tobacco smoke: carbon monoxide (CO), nicotine, tobacco smoke particles PM2,5 andpolycyclic aromatic hydrocarbons (PAHs). In the air of the examined enterprises the concentration of the major markers of tobacco smoke was established to exceed by several times acceptable and safe levels. At that in cafes and restaurants where nargile smoking the higher concentration of CO and PAHs was on average significantly more frequently than in a cafes with a rare nargile smoking. The data obtained can be used to refute the opinion on the safety of nargile smoking and tobacco smoke from the nargiles. All modern legislative and administrative measures to restrict and ban tobacco smoking should be extend to smoking nargile.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Poluição do Ar em Ambientes Fechados
Restaurantes/normas
Cachimbos de Água
Poluição por Fumaça de Tabaco
[Mh] Termos MeSH secundário: Poluição do Ar em Ambientes Fechados/análise
Poluição do Ar em Ambientes Fechados/prevenção & controle
Poluição do Ar em Ambientes Fechados/estatística & dados numéricos
Monitoramento Ambiental/métodos
Monitoramento Ambiental/normas
Seres Humanos
Federação Russa/epidemiologia
Poluição por Fumaça de Tabaco/análise
Poluição por Fumaça de Tabaco/prevenção & controle
Poluição por Fumaça de Tabaco/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:29406665
[Au] Autor:Kleier JA; Mites-Campbell M; Henson-Evertz K
[Ti] Título:Children's Exposure to Secondhand Smoke, Parental Nicotine Dependence, and Motivation to Quit Smoking.
[So] Source:Pediatr Nurs;43(1):35-9, 2017 Jan-Feb.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:More than 600,000 people die each year as a result of exposure to secondhand smoke (SHS); 28% of those deaths are children. Most exposure for children occurs in the home and is due to a parent smoking. Parental awareness and understanding of the exposure to SHS and the risk that parental smoking brings to the child may be an effective impetus for smoke avoidance and parental tobacco cessation. This descriptive, correlational study used data provided by a convenience sample of 184 smoking parental-figures, representing 376 children, recruited in community settings. Seven research questions were posed regarding the exposure of children to parental figures who smoke, the degree of the parents' dependence on nicotine, and their level of motivation to stop smoking. Comparisons were made between income levels and ethnic/racial groups. Children's exposure to SHS was low; Asian children had the highest likelihood of exposure. The areas of most frequent exposure were multiunit residential communities and in a vehicle. Parents' dependence on nicotine was moderately high, and parental motivation to quit smoking was high. However, parents who were the most dependent on nicotine were the least motivated to quit. Nurses working with both adult and pediatric populations should address the opportunities for exposure to SHS for their patient population. Community health nurses should specifically target workplaces, businesses, and communities with high numbers of Asian residents for public health education related to childhood exposure to SHS.
[Mh] Termos MeSH primário: Poluição do Ar em Ambientes Fechados/efeitos adversos
Asma/etiologia
Exposição Ambiental/efeitos adversos
Motivação
Pais/psicologia
Abandono do Hábito de Fumar/psicologia
Poluição por Fumaça de Tabaco/efeitos adversos
Tabagismo/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Feminino
Florida
Seres Humanos
Masculino
Meia-Idade
Nicotina/efeitos adversos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tobacco Smoke Pollution); 6M3C89ZY6R (Nicotine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29383710
[Au] Autor:Behbod B; Sharma M; Baxi R; Roseby R; Webster P
[Ad] Endereço:Nuffield Department of Population Health, University of Oxford, Oxford, UK.
[Ti] Título:Family and carer smoking control programmes for reducing children's exposure to environmental tobacco smoke.
[So] Source:Cochrane Database Syst Rev;1:CD001746, 2018 01 31.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Children's exposure to other people's tobacco smoke (environmental tobacco smoke, or ETS) is associated with a range of adverse health outcomes for children. Parental smoking is a common source of children's exposure to ETS. Older children in child care or educational settings are also at risk of exposure to ETS. Preventing exposure to ETS during infancy and childhood has significant potential to improve children's health worldwide. OBJECTIVES: To determine the effectiveness of interventions designed to reduce exposure of children to environmental tobacco smoke, or ETS. SEARCH METHODS: We searched the Cochrane Tobacco Addiction Group Specialised Register and conducted additional searches of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsycINFO, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Education Resource Information Center (ERIC), and the Social Science Citation Index & Science Citation Index (Web of Knowledge). We conducted the most recent search in February 2017. SELECTION CRITERIA: We included controlled trials, with or without random allocation, that enrolled participants (parents and other family members, child care workers, and teachers) involved in the care and education of infants and young children (from birth to 12 years of age). All mechanisms for reducing children's ETS exposure were eligible, including smoking prevention, cessation, and control programmes. These include health promotion, social-behavioural therapies, technology, education, and clinical interventions. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies and extracted data. Due to heterogeneity of methods and outcome measures, we did not pool results but instead synthesised study findings narratively. MAIN RESULTS: Seventy-eight studies met the inclusion criteria, and we assessed all evidence to be of low or very low quality based on GRADE assessment. We judged nine studies to be at low risk of bias, 35 to have unclear overall risk of bias, and 34 to have high risk of bias. Twenty-one interventions targeted populations or community settings, 27 studies were conducted in the well-child healthcare setting and 26 in the ill-child healthcare setting. Two further studies conducted in paediatric clinics did not make clear whether visits were made to well- or ill-children, and another included visits to both well- and ill-children. Forty-five studies were reported from North America, 22 from other high-income countries, and 11 from low- or middle-income countries. Only 26 of the 78 studies reported a beneficial intervention effect for reduction of child ETS exposure, 24 of which were statistically significant. Of these 24 studies, 13 used objective measures of children's ETS exposure. We were unable to pinpoint what made these programmes effective. Studies showing a significant effect used a range of interventions: nine used in-person counselling or motivational interviewing; another study used telephone counselling, and one used a combination of in-person and telephone counselling; three used multi-component counselling-based interventions; two used multi-component education-based interventions; one used a school-based strategy; four used educational interventions, including one that used picture books; one used a smoking cessation intervention; one used a brief intervention; and another did not describe the intervention. Of the 52 studies that did not show a significant reduction in child ETS exposure, 19 used more intensive counselling approaches, including motivational interviewing, education, coaching, and smoking cessation brief advice. Other interventions consisted of brief advice or counselling (10 studies), feedback of a biological measure of children's ETS exposure (six studies), nicotine replacement therapy (two studies), feedback of maternal cotinine (one study), computerised risk assessment (one study), telephone smoking cessation support (two studies), educational home visits (eight studies), group sessions (one study), educational materials (three studies), and school-based policy and health promotion (one study). Some studies employed more than one intervention. 35 of the 78 studies reported a reduction in ETS exposure for children, irrespective of assignment to intervention and comparison groups. One study did not aim to reduce children's tobacco smoke exposure but rather sought to reduce symptoms of asthma, and found a significant reduction in symptoms among the group exposed to motivational interviewing. We found little evidence of difference in effectiveness of interventions between the well infant, child respiratory illness, and other child illness settings as contexts for parental smoking cessation interventions. AUTHORS' CONCLUSIONS: A minority of interventions have been shown to reduce children's exposure to environmental tobacco smoke and improve children's health, but the features that differentiate the effective interventions from those without clear evidence of effectiveness remain unclear. The evidence was judged to be of low or very low quality, as many of the trials are at a high risk of bias, are small and inadequately powered, with heterogeneous interventions and populations.
[Mh] Termos MeSH primário: Cuidadores
Família
Prevenção do Hábito de Fumar
Poluição por Fumaça de Tabaco/prevenção & controle
[Mh] Termos MeSH secundário: Fatores Etários
Criança
Pré-Escolar
Ensaios Clínicos Controlados como Assunto
Cotinina/urina
Aconselhamento
Exposição Ambiental/prevenção & controle
Seres Humanos
Lactente
Recém-Nascido
Abandono do Hábito de Fumar
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Tobacco Smoke Pollution); K5161X06LL (Cotinine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD001746.pub4


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[PMID]:29329929
[Au] Autor:Filonzi L; Magnani C; Lavezzi AM; Vaghi M; Nosetti L; Nonnis Marzano F
[Ad] Endereço:Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, Parma, Italy.
[Ti] Título:Detoxification genes polymorphisms in SIDS exposed to tobacco smoke.
[So] Source:Gene;648:1-4, 2018 Mar 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The best hypothesis to explain Sudden Infant Death Syndrome (SIDS) pathogenesis is offered by the "triple risk model", which suggests that an interaction of different variables related to exogenous stressors and infant vulnerability may lead to the syndrome. Environmental factors are triggers that act during a particular sensible period, modulated by intrinsic genetic characteristics. Although literature data show that one of the major SIDS risk factors is smoking exposure, a specific involvement of molecular components has never been highlighted. Starting from these observations and considering the role of GSTT1 and GSTM1 genes functional polymorphisms in the detoxification process, we analyzed GSTM1 and GSTT1 null genotype frequencies in 47 SIDS exposed to tobacco smoke and 75 healthy individuals. A significant association (p < .0001) between the GSTM1 null genotype and SIDS exposed to smoke was found. On the contrary, no association between GSTT1 polymorphism and SIDS was determined. Results indicated the contribution of the GSTM1 -/- genotype resulting in null detoxification activity in SIDS cases, and led to a better comprehension of the triple risk model, highlighting smoking exposure as a real SIDS risk factor on a biochemical basis.
[Mh] Termos MeSH primário: Predisposição Genética para Doença/genética
Polimorfismo Genético
Morte Súbita do Lactente/genética
Poluição por Fumaça de Tabaco/efeitos adversos
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Frequência do Gene
Genótipo
Glutationa Transferase/genética
Glutationa Transferase/metabolismo
Seres Humanos
Lactente
Recém-Nascido
Masculino
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tobacco Smoke Pollution); EC 2.5.1.- (glutathione S-transferase T1); EC 2.5.1.18 (Glutathione Transferase); EC 2.5.1.18 (glutathione S-transferase M1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180114
[St] Status:MEDLINE


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[PMID]:29414275
[Au] Autor:Merrill TG; Lopez W; Perl SB; Bassett MT
[Ad] Endereço:From the New York City Department of Health and Mental Hygiene (T.G.M., S.B.P., M.T.B.) and the New York City Board of Health (T.G.M., M.T.B.) - both in New York. Mr. Lopez is counsel emeritus to both the Department of Health and Mental Hygiene and the Board of Health.
[Ti] Título:The Judicial Threat to Public Health Innovation - The Sword of Boreali.
[So] Source:N Engl J Med;378(6):499-501, 2018 Feb 08.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Regulamentação Governamental
Legislação como Assunto/história
Saúde Pública/legislação & jurisprudência
[Mh] Termos MeSH secundário: Bebidas Gaseificadas/efeitos adversos
Regulamentação Governamental/história
História do Século XX
História do Século XXI
Seres Humanos
Legislação sobre Alimentos/história
Cidade de Nova Iorque
Obesidade/etiologia
Obesidade/prevenção & controle
Saúde Pública/história
Opinião Pública
Restaurantes/legislação & jurisprudência
Poluição por Fumaça de Tabaco/história
Poluição por Fumaça de Tabaco/legislação & jurisprudência
Estados Unidos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMp1712636


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[PMID]:29390543
[Au] Autor:Zhao R; Wu Y; Zhao F; Lv Y; Huang D; Wei J; Ruan C; Huang M; Deng J; Huang D; Qiu X
[Ad] Endereço:School of Public Health, Guangxi Medical University.
[Ti] Título:The risk of missed abortion associated with the levels of tobacco, heavy metals and phthalate in hair of pregnant woman: A case control study in Chinese women.
[So] Source:Medicine (Baltimore);96(51):e9388, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To assess the association between exposure to the tobacco, heavy metals and phthalate on early pregnancy and missed abortion.42 women with missed abortion and 57 matched controls (women with normal pregnancies) were recruited between March and May 2012, from the Department of Gynecology and Obstetrics, First Affiliated Hospital of Guangxi Medical University and the People Hospital of Guangxi Zhuang Autonomous Region. The questionnaire survey was carried on to learn about the basic conditions, as well as smoking history of all participants. The levels of tobacco, heavy metal, and phthalate exposure were compared between the 2 groups by measuring nicotine, cocaine, cadmium (Cd), manganese (Mn), plumbum (Pb) and dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butyl benzyl phthalate (BBP), di-2-ethyl hexyl phthalate (DEHP) in the hair samples.Out results showed that significant differences in age (P = .042), premarital examination (P = .041), passive smoking (P = .021), and heavy metal exposure (P = .022) were found in the case group compared to the control. In addition, the concentration of nicotine (P = .037), cotinine (P = .018), Cd (P = .01), Pb (P = .038) and DEHP (P = .001) in the hair were significantly higher in the case group. Furthermore, logistic analysis revealed that age [Odds Ratio (OR) 1.172, 95% confidence interval (CI) 1.036-1.327], Cd (OR 8.931, 95% CI 2.003-39.811), Cotinine (OR 4.376, 95% CI 1.159-16.531), DEHP (OR 1.863, 95% CI 1.103-3.146) were important factors contributing to the missed abortion (P < .05).It was demonstrated that high gestational age, passive smoking, heavy metals, and the phthalate exposure were the risk factors for missed abortion, while the premarital health examination was a protective factor. Avoiding these harmful substances before getting pregnant and during the early stages of pregnancy, might help prevent missed abortions.
[Mh] Termos MeSH primário: Aborto Retido/etiologia
Exposição Ambiental/efeitos adversos
Poluentes Ambientais/toxicidade
Metais Pesados/toxicidade
Nicotina/toxicidade
Ácidos Ftálicos/toxicidade
Poluição por Fumaça de Tabaco/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
China
Exposição Ambiental/análise
Poluentes Ambientais/análise
Feminino
Cabelo/química
Seres Humanos
Modelos Logísticos
Metais Pesados/análise
Meia-Idade
Nicotina/análise
Ácidos Ftálicos/análise
Gravidez
Fatores de Proteção
Fatores de Risco
Poluição por Fumaça de Tabaco/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Metals, Heavy); 0 (Phthalic Acids); 0 (Tobacco Smoke Pollution); 6M3C89ZY6R (Nicotine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009388


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[PMID]:28452951
[Au] Autor:Hang B; Wang P; Zhao Y; Sarker A; Chenna A; Xia Y; Snijders AM; Mao JH
[Ad] Endereço:Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. bo_hang@lbl.gov.
[Ti] Título:Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models.
[So] Source:Int J Mol Sci;18(5), 2017 Apr 28.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by "the four Rs": tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS.
[Mh] Termos MeSH primário: Poluição por Fumaça de Tabaco
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/toxicidade
Animais
Apoptose/efeitos dos fármacos
Adutos de DNA/química
Adutos de DNA/metabolismo
Dano ao DNA/efeitos dos fármacos
Seres Humanos
Sistema Imunitário/efeitos dos fármacos
Sistema Imunitário/metabolismo
Modelos Animais
Reprodução/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Air Pollutants); 0 (DNA Adducts); 0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
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[PMID]:28464887
[Au] Autor:Mahabee-Gittens EM; Ammerman RT; Khoury JC; Stone L; Meyers GT; Witry JK; Merianos AL; Mancuso TF; Stackpole KMW; Bennett BL; Akers L; Gordon JS
[Ad] Endereço:Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA. Melinda.Mahabee-Gittens@cchmc.org.
[Ti] Título:Healthy families: study protocol for a randomized controlled trial of a screening, brief intervention, and referral to treatment intervention for caregivers to reduce secondhand smoke exposure among pediatric emergency patients.
[So] Source:BMC Public Health;17(1):374, 2017 05 02.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Involuntary exposure to secondhand smoke (SHSe) is an important cause of morbidity in children who present to the pediatric emergency department (PED) and urgent care (UC). SHSe interventions delivered in the PED and UC would benefit both the smoker and child, but there have been no large trials testing the efficacy of such interventions. The Healthy Families program is the first randomized controlled trial to test whether a screening, brief intervention, and referral to treatment (SBIRT) intervention delivered in the PED and UC will be effective in decreasing SHSe in children and increasing cessation in smokers. METHODS/DESIGN: This trial uses a randomized, two-group design in which caregiver-smokers of children 0-17 years old are recruited from the PED and UC. Eligible caregiver-smokers are randomized to either the: 1) SBIRT Condition with face-to-face, tailored counseling that focuses on the child's illness, the importance of reducing child SHSe, caregiver smoking cessation, and the option to receive nicotine replacement therapy; or 2) Healthy Habits Control Condition which includes face-to-face, tailored attention control "5-2-1-0" counseling that focuses on improving the child's health. Dyadic assessments are conducted in-person at baseline, and via email, phone, or in-person at 6-weeks and 6-months. The primary outcomes are biochemically-verified, 7-day point prevalence and prolonged smoking abstinence. Secondary outcomes are cigarettes smoked per week, 24 h quit attempts, and biochemically validated child SHSe at each time point. The costs of this intervention will also be analyzed. DISCUSSION: This study will test an innovative, multilevel intervention designed to reduce child SHSe and increase smoking cessation in caregivers. If effective and routinely used, this SBIRT model could reach at least one million smokers a year in the U.S., resulting in significant reductions in caregivers' tobacco use, SHSe-related pediatric illness, and healthcare costs in this population of children. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02531594. Date of registration: August 4, 2015.
[Mh] Termos MeSH primário: Assistência Ambulatorial/organização & administração
Cuidadores
Encaminhamento e Consulta/organização & administração
Abandono do Hábito de Fumar/métodos
Poluição por Fumaça de Tabaco/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Serviço Hospitalar de Emergência
Saúde da Família
Seres Humanos
Lactente
Recém-Nascido
Masculino
Projetos de Pesquisa
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180121
[Lr] Data última revisão:
180121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12889-017-4278-8


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[PMID]:28741144
[Au] Autor:Makadia LD; Roper PJ; Andrews JO; Tingen MS
[Ad] Endereço:Medical College of Georgia, Augusta University, Augusta, GA, USA.
[Ti] Título:Tobacco Use and Smoke Exposure in Children: New Trends, Harm, and Strategies to Improve Health Outcomes.
[So] Source:Curr Allergy Asthma Rep;17(8):55, 2017 Aug.
[Is] ISSN:1534-6315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Every day in the USA, approximately 4000 adolescents begin smoking and the adolescent brain is particularly susceptible to nicotine addiction. We present current pediatric trends on tobacco use and exposures, various new products used by adolescents, the adverse biological and behavioral effects of tobacco use and exposures, and tobacco control strategies to eliminate tobacco-related illnesses and deaths in the pediatric population. RECENT FINDINGS: Twelve-20% of women continue to smoke during pregnancy. New research reveals cognitive differences and behavior-control disorders are seen in elementary school children from prenatal and postnatal exposures. Traditional cigarette smoking has decreased in adolescents; novel and appealing tobacco products have captured their attention, particularly electronic cigarettes, and rates double and often triple from middle to high school. Children with asthma and those living in multi-housing units have higher rates of secondhand smoke exposure than non-asthmatics and children living in single-home dwellings. There is no "safe or risk-free" level of tobacco use or exposure. Tobacco use and exposure in childhood and adolescence must be decreased using evidenced-based strategies to improve child health.
[Mh] Termos MeSH primário: Poluição por Fumaça de Tabaco
Uso de Tabaco
[Mh] Termos MeSH secundário: Sistema Cardiovascular/efeitos dos fármacos
Criança
Comportamento Infantil/efeitos dos fármacos
Sistemas Eletrônicos de Liberação de Nicotina
Exposição Ambiental
Feminino
Seres Humanos
Rim/efeitos dos fármacos
Obesidade/epidemiologia
Gravidez
Efeitos Tardios da Exposição Pré-Natal
Sistema Respiratório/efeitos dos fármacos
Instituições Acadêmicas
Fumaça
Produtos do Tabaco/efeitos adversos
Produtos do Tabaco/economia
Produtos do Tabaco/legislação & jurisprudência
Poluição por Fumaça de Tabaco/efeitos adversos
Poluição por Fumaça de Tabaco/legislação & jurisprudência
Poluição por Fumaça de Tabaco/prevenção & controle
Uso de Tabaco/efeitos adversos
Uso de Tabaco/legislação & jurisprudência
Uso de Tabaco/prevenção & controle
Uso de Tabaco/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Smoke); 0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1007/s11882-017-0723-0



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