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Pesquisa : D20.749.354 [Categoria DeCS]
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  1 / 1021 MEDLINE  
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[PMID]:28315805
[Au] Autor:Gallacher C; Thomas R; Taylor C; Lord R; Kalin RM
[Ad] Endereço:Department of Civil and Env. Eng., University of Strathclyde, 75 Montrose St., Glasgow, UK. Electronic address: christopher.gallacher@strath.ac.uk.
[Ti] Título:Comprehensive composition of Creosote using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOFMS).
[So] Source:Chemosphere;178:34-41, 2017 Jul.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Creosote is a distillation product of coal tar and is widely used as wood preservative for railway sleepers, utility poles and for other applications. Creosote can have potentially negative effects on the environment and many of the components are toxic. This study presents the analysis of a Creosote sample from a former wood impregnation plant located in the UK. The sample was analysed using two dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOFMS) and a database of compounds that could be detected was produced. The GCxGG-TOFMS was capable of detecting 1505 individual compounds, which is far more than previous estimates for the number of compounds present within Creosote. Post extraction derivatization using BTSFA with 1% TMCS was employed to increase the potential number of compounds detected with 255 derivatized compounds detected, 231 of which would not have been detected without prior derivatization. Selected derivatized compounds were quantified with limits of detection ranging from 0.6 mg/kg to 1.6 mg/kg from a concentrated dense non-aqueous phase liquid (DNAPL). This work presents the first published full analysis of a Creosote using GCxGC-TOFMS combined with derivatization.
[Mh] Termos MeSH primário: Creosoto/análise
Poluentes Ambientais/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
[Mh] Termos MeSH secundário: Alcatrão/química
Creosoto/química
Poluentes Ambientais/toxicidade
Extração Líquido-Líquido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 8007-45-2 (Coal Tar); 8021-39-4 (Creosote)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170320
[St] Status:MEDLINE


  2 / 1021 MEDLINE  
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[PMID]:28088531
[Au] Autor:Li J; Zhang Y; Peng J; Wu X; Gao S; Mao L
[Ad] Endereço:State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China.
[Ti] Título:The effect of dissolved organic matter on soybean peroxidase-mediated removal of triclosan in water.
[So] Source:Chemosphere;172:399-407, 2017 Apr.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dissolved organic matter (DOM) is ubiquitous in water and involved in numerous important chemical processes in aqueous systems, enabling it a unique challenge for a variety of water treatment processes. Soybean peroxidase (SBP)-based enzymatic process, as a promising treatment technique, has been successfully applied to remove pollutants in wastewaters such as coal-tar and refinery wastewater. In this study, the effect of DOM on the removal of polychlorinated aromatic antimicrobials triclosan (TCS) by SBP was investigated. Our results suggested that DOM significantly suppressed the catalytic performance of SBP to TCS, presumably resulting from the competition of the phenolic moiety in DOM structure as the active substrate of SBP via the analysis of excitation emission matrix (EEM) spectra of DOM. Although the product species of TCS in SBP-mediated system with DOM has no change compared with the system without DOM, the yields of self-coupling products relative to total transformed TCS were remarkably reduced in the presence of DOM, suggesting that DOM participated in the oxidative coupling reactions. Cross-coupling between TCS and DOM was also verified using guaiacol as a model DOM constituent. Moreover, the products including self-coupling products and co-polymers in SBP-mediated TCS reaction system with DOM were innocuous through growth inhibition assay of S. obliquus.
[Mh] Termos MeSH primário: Clorófitas/metabolismo
Peroxidases/química
Feijão de Soja/enzimologia
Triclosan/análise
Poluentes Químicos da Água/análise
Água/análise
[Mh] Termos MeSH secundário: Reatores Biológicos
Catálise
Cromatografia Líquida de Alta Pressão
Cromatografia Líquida
Alcatrão
Corantes/análise
Guaiacol/química
Cinética
Espectrometria de Massas
Fenol/química
Águas Residuais/análise
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Waste Water); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 339NCG44TV (Phenol); 4NM5039Y5X (Triclosan); 6JKA7MAH9C (Guaiacol); 8007-45-2 (Coal Tar); EC 1.11.1.- (Peroxidases); EC 1.11.1.7 (anionic peroxidase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170116
[St] Status:MEDLINE


  3 / 1021 MEDLINE  
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[PMID]:27938808
[Au] Autor:Engin B; Askin Ö; Tüzün Y
[Ad] Endereço:Department of Dermatology, Cerrahpasa Medical Faculty, Istanbul University, Fatih, Istanbul, Turkey. Electronic address: burhanengin2000@yahoo.com.
[Ti] Título:Palmoplantar psoriasis.
[So] Source:Clin Dermatol;35(1):19-27, 2017 Jan - Feb.
[Is] ISSN:1879-1131
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Palmoplantar psoriasis refers to a localized psoriasis variant. The disease can be associated with many clinical forms, including predominantly pustular lesions to thick scaly, hyperkeratotic plaques, or an overlapping of both of them. Palmoplantar psoriasis accounts for 3-4% of all psoriasis cases in most studies. Although it is localized only on the palms and the soles, the fissures, the hardening of the tissue, and hyperkeratosis affect daily routine activities. Taking the body surface area as a measure of severity can sometimes be misleading. In clinical practice, the level of functional impairment should be taken into account rather than relying on traditional instruments to evaluate the severity. Palmoplantar psoriasis is usually managed with topical therapy as a first step. Systemic therapy is needed when the topicals fail or when the disease becomes more severe. Sometimes, biologic agents are required for adequate maintenance of clinical response.
[Mh] Termos MeSH primário: Produtos Biológicos/uso terapêutico
Fármacos Dermatológicos/uso terapêutico
Dermatoses do Pé/terapia
Dermatoses da Mão/terapia
Psoríase/complicações
Psoríase/terapia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Alcatrão/uso terapêutico
Fármacos Dermatológicos/administração & dosagem
Dermatoses do Pé/etiologia
Dermatoses da Mão/etiologia
Seres Humanos
Ácidos Nicotínicos/uso terapêutico
Terapia PUVA
Psoríase/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Biological Products); 0 (Dermatologic Agents); 0 (Nicotinic Acids); 8007-45-2 (Coal Tar); 81BDR9Y8PS (tazarotene)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  4 / 1021 MEDLINE  
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[PMID]:27930978
[Au] Autor:El-Gharabawy RM; Ahmed AS; Al-Najjar AH
[Ad] Endereço:Pharmacology and Toxicology Department, College of Pharmacy, Qassim University, Saudi Arabia; Pharmacology and Toxicology Department, College of Pharmacy, Tanta University, Egypt. Electronic address: drrehab200932@yahoo.com.
[Ti] Título:Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis.
[So] Source:Biomed Pharmacother;85:141-147, 2017 Jan.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this work is to study the possible mechanisms through which different immune-modulating agents can produce their beneficial effects on treatment of psoriasis and to determine whether the supplementation of these agents for psoriasis patients induces regression of psoriasis. SUBJECTS AND METHODS: One hundred fifty participants were included in this study. The participants were divided into five groups: 1. Normal control group, 2. Psoriasis patients not taking any treatment, 3. Psoriasis patients treated with anti-psoriatic treatment (including coal tar, vitamin D3 analogues and corticosteroids). 4. Psoriasis patients treated with anti-psoriatic treatment and oral metformin (850mg twice daily) and 5. Psoriasis patients treated with anti-psoriatic treatment and oral pioglitazone (15mg once a day). Demographic characteristics, diabetic index, lipid profile and liver function tests were monitored. The CD4+ Tcells, CD8+ Tcells, CD4+/CD8+ ratio, interleukin-2 (IL-2), C-reactive protein (CRP) and ceruloplasmin (CP) were assayed. RESULTS: After treatment of psoriasis patients with a traditional anti-psoriatic drug in combination with metformin and peroxisome proliferator-activated receptor gamma (PPARɤ) agonist (pioglitazone), the CD4+ T cells, IL-2, CRP, CP, ALT and AST levels were statistically significantly decreased compared to psoriasis patients without treatment. Positive and significant correlations between CD4+ % and IL-2, CRP, CP, ALT and AST in psoriasis patients were recorded. CONCLUSIONS: The activation of PPAR-γ receptors by pioglitazone results in reduced formation of the proinflammatory cytokines and infiltration by inflammatory cells. Additionally, metformin acts as a modulator of the immune system in psoriasis patients and has a remarkable effect on the early stages of psoriasis. Therefore, either pioglitazone or metformin in combination with traditional anti-psoriatic drugs provides better results in the treatment of psoriasis than does each alone.
[Mh] Termos MeSH primário: Fatores Imunológicos/uso terapêutico
Metformina/uso terapêutico
Psoríase/tratamento farmacológico
Tiazolidinedionas/uso terapêutico
[Mh] Termos MeSH secundário: Corticosteroides/administração & dosagem
Corticosteroides/uso terapêutico
Adulto
Colecalciferol/análogos & derivados
Colecalciferol/uso terapêutico
Alcatrão/administração & dosagem
Alcatrão/uso terapêutico
Quimioterapia Combinada
Feminino
Seres Humanos
Hipoglicemiantes/administração & dosagem
Hipoglicemiantes/uso terapêutico
Masculino
Metformina/administração & dosagem
Meia-Idade
Psoríase/imunologia
Tiazolidinedionas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Hypoglycemic Agents); 0 (Immunologic Factors); 0 (Thiazolidinediones); 1C6V77QF41 (Cholecalciferol); 8007-45-2 (Coal Tar); 9100L32L2N (Metformin); X4OV71U42S (pioglitazone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170222
[Lr] Data última revisão:
170222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE


  5 / 1021 MEDLINE  
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[PMID]:27883276
[Au] Autor:Gao H; Ding L; Bai H; Li L
[Ad] Endereço:Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen, 361005, P. R. China.
[Ti] Título:Microporous Organic Polymers Based on Hyper-Crosslinked Coal Tar: Preparation and Application for Gas Adsorption.
[So] Source:ChemSusChem;10(3):618-623, 2017 Feb 08.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Hyper-crosslinked polymers (HCPs) are promising materials for gas capture and storage, but high cost and complicated preparation limit their practical application. In this paper, a new type of HCPs (CTHPs) was synthesized through a one-step mild Friedel-Crafts reaction with low-cost coal tar as the starting material. Chloroform was utilized as both solvent and crosslinker to generate a three-dimensional crosslinked network with abundant micropores. The maximum BET surface area of the prepared CTHPs could reach up to 929 m g . Owing to the high affinity between the heteroatoms on the coal-tar building blocks and the CO molecules, the adsorption capacity of CTHPs towards CO reached up to 14.2 wt % (1.0 bar, 273 K) with a high selectivity (CO /N =32.3). Furthermore, the obtained CTHPs could adsorb 1.27 wt % H at 1.0 bar and 77.3 K, and also showed capacity for the capture of high organic vapors at room temperature. In comparison with other reported porous organic polymers, CTHPs have the advantages of low-cost, easy preparation, and high gas-adsorption performance, making them suitable for mass production and practical use in the future.
[Mh] Termos MeSH primário: Dióxido de Carbono/química
Alcatrão/química
Hidrogênio/química
Compostos Orgânicos/química
Polímeros/química
[Mh] Termos MeSH secundário: Adsorção
Porosidade
Temperatura Ambiente
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organic Chemicals); 0 (Polymers); 142M471B3J (Carbon Dioxide); 7YNJ3PO35Z (Hydrogen); 8007-45-2 (Coal Tar)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201601475


  6 / 1021 MEDLINE  
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[PMID]:27745637
[Au] Autor:Farahnik B; Beroukhim K; Danesh M; Nakamura M; Abrouk M; Zhu TH; Singh R; Lee K; Bhutani T; Koo J
[Ad] Endereço:University of Vermont College of Medicine, Burlington. Electronic address: Benjamin.Farahnik@med.uvm.edu.
[Ti] Título:Successful use of a modified Goeckerman regimen in the treatment of chronic severe atopic dermatitis: A prospective pilot study.
[So] Source:J Am Acad Dermatol;75(5):1068-1071, 2016 Nov.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Corticosteroides/uso terapêutico
Anti-Inflamatórios/uso terapêutico
Alcatrão/uso terapêutico
Dermatite Atópica/radioterapia
Ceratolíticos/uso terapêutico
Terapia Ultravioleta/métodos
[Mh] Termos MeSH secundário: Administração Cutânea
Corticosteroides/administração & dosagem
Adulto
Anti-Inflamatórios/administração & dosagem
Antipruriginosos/administração & dosagem
Antipruriginosos/uso terapêutico
Alcatrão/administração & dosagem
Terapia Combinada
Dermatite Atópica/tratamento farmacológico
Feminino
Seres Humanos
Ceratolíticos/administração & dosagem
Masculino
Projetos Piloto
Estudos Prospectivos
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Anti-Inflammatory Agents); 0 (Antipruritics); 0 (Keratolytic Agents); 8007-45-2 (Coal Tar)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


  7 / 1021 MEDLINE  
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[PMID]:27700018
[Au] Autor:Jung MY; Kim JG; Sinninghe Damsté JS; Rijpstra WI; Madsen EL; Kim SJ; Hong H; Si OJ; Kerou M; Schleper C; Rhee SK
[Ad] Endereço:Department of Microbiology, Chungbuk National University, 1 Chungdae-ro, Seowon-Gu, Cheongju, 28644, South Korea.
[Ti] Título:A hydrophobic ammonia-oxidizing archaeon of the Nitrosocosmicus clade isolated from coal tar-contaminated sediment.
[So] Source:Environ Microbiol Rep;8(6):983-992, 2016 12.
[Is] ISSN:1758-2229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A wide diversity of ammonia-oxidizing archaea (AOA) within the phylum Thaumarchaeota exists and plays a key role in the N cycle in a variety of habitats. In this study, we isolated and characterized an ammonia-oxidizing archaeon, strain MY3, from a coal tar-contaminated sediment. Phylogenetically, strain MY3 falls in clade 'Nitrosocosmicus' of the thaumarchaeotal group I.1b. The cells of strain MY3 are large 'walnut-like' cocci, divide by binary fission along a central cingulum, and form aggregates. Strain MY3 is mesophilic and neutrophilic. An assay of C-bicarbonate incorporation into archaeal membrane lipids indicated that strain MY3 is capable of autotrophy. In contrast to some other AOA, TCA cycle intermediates, i.e. pruvate, oxaloacetate and α-ketoglutarate, did not affect the growth rates and yields of strain MY3. The attachment of cells of strain MY3 to XAD-7 hydrophobic beads and to the adsorbent vermiculite demonstrated the potential of strain MY3 to form biofilms. The cell surface was confirmed to be hydrophobic by the extraction of strain MY3 from an aqueous medium with p-xylene. Our finding of a strong potential for surface attachment by strain MY3 may reflect an adaptation to the selective pressures in hydrophobic terrestrial environments.
[Mh] Termos MeSH primário: Amônia/metabolismo
Archaea/isolamento & purificação
Archaea/metabolismo
Microbiologia Ambiental
[Mh] Termos MeSH secundário: Archaea/classificação
Archaea/citologia
Carbono/metabolismo
Alcatrão
Poluentes Ambientais
Oxirredução
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Environmental Pollutants); 7440-44-0 (Carbon); 7664-41-7 (Ammonia); 8007-45-2 (Coal Tar)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE
[do] DOI:10.1111/1758-2229.12477


  8 / 1021 MEDLINE  
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[PMID]:27639151
[Au] Autor:Beránek M; Fiala Z; Kremlácek J; Andrýs C; Hamáková K; Palicka V; Borská L
[Ad] Endereço:Department of Biochemical Sciences, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Hradec Králové, Czech Republic. beranek@lfhk.cuni.cz.
[Ti] Título:Droplet Digital PCR Analysis of GSTM1 Deletion Polymorphism in Psoriatic Subjects Treated with Goeckerman Therapy.
[So] Source:Acta Medica (Hradec Kralove);59(3):75-78, 2016.
[Is] ISSN:1211-4286
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:Goeckerman therapy (GT) represents an effective treatment of psoriasis including a combination of pharmaceutical grade crude coal tar (CCT) and ultraviolet irradiation (UV-R). Coal tar contains a mixture of polycyclic aromatic hydrocarbons. The best known carcinogenic polyaromate - benzo[a]pyrene is metabolized into a highly reactive benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE). Glutathione S-transferase M1 (GSTM1) catalyses the conjugation of drugs, toxins and products of oxidative stress with glutathione. The aim of the study is to found possible associations between GSTM1 genotypes and the level of BPDE-DNA adducts in 46 psoriatic patients treated with GT. For genotyping, droplet digital PCR was applied. The GSTM1 copy number was normalized to ß-globin reference gene. In five GSTM1*1/*1 subjects, the GSTM1 to ß-globin ratio moved from 0.99 to 1.03 with a median of 1.01. GSTM1*0/*1 heterozygotes (n = 20) contained only one GSTM1 function allele which conditioned the ratio 0.47-0.53 (median 0.50). GSTM1*0/*0 individuals (n = 21) showed no amplification of the null variants because of the large deletion in GSTM1. BPDE-DNA concentrations ranged from 1.8 to 66.3 ng/µg with a median of 12.3 ng/µg. GSTM1*0/*0 and GSTM1*0/*1 genotypes showed non-significantly higher concentrations of BPDE-DNA adducts than the GSTM1*1/*1 one (12.3 and 12.4 vs 7.8 ng/µg). The non-significant relationship between BPDE-DNA adducts and GSTM1 genotypes in psoriatic patients could be associated with relatively low doses of CCT and short-term UV-R exposures used in GT.
[Mh] Termos MeSH primário: Sequência de Bases
Glutationa Transferase/genética
Reação em Cadeia da Polimerase/métodos
Psoríase/genética
Psoríase/terapia
Deleção de Sequência
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Alcatrão/uso terapêutico
Terapia Combinada
Adutos de DNA
Análise Mutacional de DNA/métodos
Feminino
Genótipo
Seres Humanos
Ceratolíticos/uso terapêutico
Masculino
Meia-Idade
Polimorfismo Genético
Terapia Ultravioleta
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Adducts); 0 (Keratolytic Agents); 8007-45-2 (Coal Tar); EC 2.5.1.18 (Glutathione Transferase); EC 2.5.1.18 (glutathione S-transferase M1)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE
[do] DOI:10.14712/18059694.2016.94


  9 / 1021 MEDLINE  
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[PMID]:27638440
[Au] Autor:Rodenbeck DL; Silverberg JI; Silverberg NB
[Ad] Endereço:Departments of Dermatology, Preventive Medicine, and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.
[Ti] Título:Phototherapy for atopic dermatitis.
[So] Source:Clin Dermatol;34(5):607-13, 2016 Sep-Oct.
[Is] ISSN:1879-1131
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phototherapy is a second-line treatment for moderate to severe atopic dermatitis (AD) that effectively decreases cutaneous inflammation with minimal or no systemic side effects. Children in grade school, adolescents, and adults may benefit from phototherapy, when they have chronic AD refractory to first-line topical treatments. This review focuses on six approaches for phototherapy in AD: (1) broadband ultraviolet B (UVB), (2) Goeckerman regimen (coal tar + broadband UVB), (3) narrowband UVB, (4) excimer lasers for targeted areas, (5) combination UVA/UVB, and (6) UVA-1. Phototherapy can be very effective in some individuals, but it is limited by inconvenience and adverse effects, including limited access to in-office treatment, difficulty adhering to thrice-weekly schedule, flaring from excessive heat, and increased risk of skin cancer. Dosing regimen and treatment concerns are reviewed.
[Mh] Termos MeSH primário: Dermatite Atópica/tratamento farmacológico
Dermatite Atópica/radioterapia
Lasers de Excimer/uso terapêutico
Fotoquimioterapia
Terapia Ultravioleta/métodos
[Mh] Termos MeSH secundário: Alcatrão/uso terapêutico
Seres Humanos
Ceratolíticos/uso terapêutico
Guias de Prática Clínica como Assunto
Terapia Ultravioleta/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Keratolytic Agents); 8007-45-2 (Coal Tar)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE


  10 / 1021 MEDLINE  
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[PMID]:27617950
[Au] Autor:Nakamura M; Koo J; Bhutani T
[Ad] Endereço:Department of Dermatology, University of California San Francisco. mio.nakamura@ucsf.edu.
[Ti] Título:Uremic pruritus treated successfully with the Goeckerman Program.
[So] Source:Dermatol Online J;22(8), 2016 Aug 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Uremic pruritus (UP) is a common condition among patients with chronic kidney disease (CKD) on hemodialysis (HD). We report 19 a case of severe UP recalcitrant to conventional therapy including topical corticosteroids, anti-histamines, and phototherapy, 20 which was treated successfully with the Goeckerman regimen consisting of topical coal tar, topical corticosteroids, and broadband 21 UVB (BB-UVB). Little is known about the pathophysiology of UP, and there is currently no consensus or evidence-based 22 treatments for UP. Although further studies are necessary, Goeckerman therapy may be a promising treatment option when 23 available for severe UP intractable to conventional therapies.
[Mh] Termos MeSH primário: Alcatrão/uso terapêutico
Glucocorticoides/uso terapêutico
Ceratolíticos/uso terapêutico
Fotoquimioterapia
Prurido/tratamento farmacológico
Triancinolona/uso terapêutico
Terapia Ultravioleta/métodos
[Mh] Termos MeSH secundário: Administração Cutânea
Idoso
Seres Humanos
Falência Renal Crônica/complicações
Falência Renal Crônica/terapia
Masculino
Prurido/etiologia
Diálise Renal
Uremia/complicações
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Keratolytic Agents); 1ZK20VI6TY (Triamcinolone); 8007-45-2 (Coal Tar)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE



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