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[PMID]:27775689
[Au] Autor:Yang J; Wang T; Li Y; Yao W; Ji X; Wu Q; Han L; Han R; Yan W; Yuan J; Ni C
[Ad] Endereço:Department of Occupational Medicine and Environmental Health and Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
[Ti] Título:Earthworm extract attenuates silica-induced pulmonary fibrosis through Nrf2-dependent mechanisms.
[So] Source:Lab Invest;96(12):1279-1300, 2016 12.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Silicosis is an occupational pulmonary fibrosis caused by inhalation of silica (SiO ) and there are no ideal drugs to treat this disease. Earthworm extract (EE), a natural nutrient, has been reported to have anti-inflammatory, antioxidant, and anti-apoptosis effects. The purpose of the current study was to test the protective effects of EE against SiO -induced pulmonary fibrosis and to explore the underlying mechanisms using both in vivo and in vitro models. We found that treatment with EE significantly reduced lung inflammation and fibrosis and improved lung structure and function in SiO -instilled mice. Further mechanistic investigations revealed that EE administration markedly inhibited SiO -induced oxidative stress, mitochondrial apoptotic pathway, and epithelial-mesenchymal transition in HBE and A549 cells. Furthermore, we demonstrate that Nrf2 activation partly mediates the interventional effects of EE against SiO -induced pulmonary fibrosis. Our study has identified EE to be a potential anti-oxidative, anti-inflammatory, and anti-fibrotic drug for silicosis.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Modelos Animais de Doenças
Pulmão/efeitos dos fármacos
Materia Medica/uso terapêutico
Oligoquetos/química
Fibrose Pulmonar/prevenção & controle
Silicose/tratamento farmacológico
Extratos de Tecidos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/farmacologia
Anti-Inflamatórios não Esteroides/uso terapêutico
Antioxidantes/administração & dosagem
Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Linhagem Celular
Células Cultivadas
Transição Epitelial-Mesenquimal/efeitos dos fármacos
Injeções Intraperitoneais
Pulmão/metabolismo
Pulmão/patologia
Pulmão/fisiopatologia
Masculino
Materia Medica/administração & dosagem
Materia Medica/farmacologia
Camundongos Endogâmicos C57BL
Fator 2 Relacionado a NF-E2/agonistas
Fator 2 Relacionado a NF-E2/antagonistas & inibidores
Fator 2 Relacionado a NF-E2/genética
Fator 2 Relacionado a NF-E2/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Fibrose Pulmonar/etiologia
Fibrose Pulmonar/imunologia
Interferência de RNA
Distribuição Aleatória
Mucosa Respiratória/citologia
Mucosa Respiratória/efeitos dos fármacos
Mucosa Respiratória/metabolismo
Mucosa Respiratória/patologia
Silicose/metabolismo
Silicose/patologia
Silicose/fisiopatologia
Organismos Livres de Patógenos Específicos
Extratos de Tecidos/administração & dosagem
Extratos de Tecidos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antioxidants); 0 (Materia Medica); 0 (NF-E2-Related Factor 2); 0 (Tissue Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2016.101


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[PMID]:29261770
[Au] Autor:Wang B; Liu D; Wang C; Wang Q; Zhang H; Liu G; He Q; Zhang L
[Ad] Endereço:Marine Bio-pharmaceutical Institute, Second Military Medical University, Shanghai, China.
[Ti] Título:Tentacle extract from the jellyfish Cyanea capillata increases proliferation and migration of human umbilical vein endothelial cells through the ERK1/2 signaling pathway.
[So] Source:PLoS One;12(12):e0189920, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wound healing is a complex biological process, and current research finds that jellyfish have a great capacity for promoting growth and healing. However, the underlying mechanisms remain unclear. Thus, this study was conducted to investigate the molecular mechanisms and effects of a tentacle extract (TE) from the jellyfish Cyanea capillata (C. capillata) on cell proliferation and migration in human umbilical vein endothelial cells (HUVECs). First, our results showed that TE at the concentration of 1 µg/ml could promote cell proliferation over various durations, induce a transition of the cells from the G1-phase to the S/G2-phase of the cell cycle, and increase the expression of cell cycle proteins (CyclinB1 and CyclinD1). Second, we found that TE could activate the PI3K/Akt, ERK1/2 and JNK MAPK signaling pathways but not the NF-κB signaling pathway or the apoptosis signaling cascade. Finally, we demonstrated that the TE-induced expression of cell cycle proteins was decreased by ERK1/2 inhibitor PD98059 but not by PI3K inhibitor LY294002 or JNK inhibitor SP600125. Similarly, the TE-enhanced migration ability of HUVECs was also markedly attenuated by PD98059. Taken together, our findings indicate that TE-induced proliferation and migration in HUVECs mainly occurred through the ERK1/2 MAPK signaling pathway. These results are instructively important for further research on the isolation and purification of growth-promoting factors from C. capillata and are hopeful as a means to improve human wound repair in unfavorable conditions.
[Mh] Termos MeSH primário: Estruturas Animais/química
Movimento Celular/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/citologia
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Cifozoários/anatomia & histologia
Extratos de Tecidos/farmacologia
[Mh] Termos MeSH secundário: Animais
Ciclo Celular/efeitos dos fármacos
Proteínas de Ciclo Celular/metabolismo
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Ciclinas/metabolismo
Imunofluorescência
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/metabolismo
Seres Humanos
NF-kappa B/metabolismo
Fosfatidilinositol 3-Quinases/metabolismo
Fosforilação/efeitos dos fármacos
Inibidores de Proteínas Quinases/farmacologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Cycle Proteins); 0 (Cyclins); 0 (NF-kappa B); 0 (Protein Kinase Inhibitors); 0 (Tissue Extracts); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189920


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[PMID]:27778194
[Au] Autor:Jacobs HN; Rathod S; Wolf MT; Elisseeff JH
[Ad] Endereço:Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, 21287, USA.
[Ti] Título:Intra-articular Injection of Urinary Bladder Matrix Reduces Osteoarthritis Development.
[So] Source:AAPS J;19(1):141-149, 2017 01.
[Is] ISSN:1550-7416
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Micronized porcine urinary bladder matrix (UBM) is an extracellular matrix biomaterial that has immunomodulatory and pro-regenerative properties. The objective of this study was to assess the ability of UBM to alter disease progression in a mouse model of post-traumatic osteoarthritis (OA). Ten-week-old wild-type C57BL/6 male mice underwent anterior cruciate ligament transection (ACLT) to induce OA. Two weeks after ACLT, UBM (50 mg/mL) or saline was injected into the mouse joint. At 4 and 8 weeks post-ACLT, cartilage integrity was assessed using OARSI scoring of histology, pain was evaluated, and joints were harvested for quantitative RT-PCR analysis of cartilage-specific and inflammatory gene expression. UBM-treated animals showed improved cartilage integrity at 4 and 8 weeks and reduced pain at 4 weeks compared to saline-injected mice. Animals injected with UBM expressed higher levels of genes encoding structural cartilage proteins, such as collagen2α1 and aggrecan, as well as anti-inflammatory cytokines, including interleukins 10 and 4. UBM decreased cartilage degeneration in the murine ACLT model of OA, which may be due to reduced inflammation in the joint and maintenance of high expression levels of proteoglycans.
[Mh] Termos MeSH primário: Lesões do Ligamento Cruzado Anterior/complicações
Fatores Imunológicos/uso terapêutico
Osteoartrite/tratamento farmacológico
Extratos de Tecidos/uso terapêutico
Bexiga Urinária/química
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Fatores Imunológicos/administração & dosagem
Injeções Intra-Arteriais
Masculino
Camundongos Endogâmicos C57BL
Osteoartrite/etiologia
Osteoartrite/imunologia
Osteoartrite/patologia
Extratos de Tecidos/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunologic Factors); 0 (Tissue Extracts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1208/s12248-016-9999-6


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[PMID]:28862540
[Au] Autor:Petersen K; Hultman MT; Bytingsvik J; Harju M; Evenset A; Tollefsen KE
[Ad] Endereço:a Section of Ecotoxicology , Norwegian Institute for Water Research (NIVA) , Oslo , Norway.
[Ti] Título:Characterizing cytotoxic and estrogenic activity of Arctic char tissue extracts in primary Arctic char hepatocytes.
[So] Source:J Toxicol Environ Health A;80(16-18):1017-1030, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Contaminants from various anthropogenic activities are detected in the Arctic due to long-range atmospheric transport, ocean currents, and living organisms such as migrating fish or seabirds. Although levels of persistent organic pollutants (POPs) in Arctic fish are generally low, local hot spots of contamination were found in freshwater systems such as Lake Ellasjøen at Bjørnøya (Bear Island, Norway). Higher concentrations of organic halogenated compounds (OHC), and higher levels of cytochrome P450 and DNA-double strand breaks were reported in Arctic char (Salvelinus alpinus) from this lake compared to fish from other lakes on Bjørnøya. Although several of the measured contaminants are potential endocrine disrupters, few studies have investigated potential endocrine disruptive effects of the contaminant cocktail in this fish population. The aim of this study was to compare acutely toxic and estrogenic potency of the cocktail of pollutants as evidenced by cytotoxic and/or estrogenic effects in vitro using extracts of Arctic char livers from contaminated Lake Ellasjøen with those from less contaminated Lake Laksvatn at Bjørnøya. This was performed by in situ sampling and contaminant extraction from liver tissue, followed by chemical analysis and in vitro testing of the following contaminated tissue extracts: F1-nonpolar OHC, F2-polar pesticides and metabolites of OHC, and F3-polar OHC. Contaminant levels were highest in extracts from Ellasjøen fish. The F2 and F3 extracts from Lake Laksvatn and Lake Ellasjøen fish reduced in vitro cell viability at a concentration ratio of 0.03-1 relative to tissue concentration in Arctic char. Only the F3 liver extract from Ellasjøen fish increased in vitro vitellogenin protein expression. Although compounds such as estrogenic OH-PCBs were quantified in Ellasjøen F3 extracts, it remains to be determined which compounds were inducing estrogenic effects.
[Mh] Termos MeSH primário: Hepatócitos/efeitos dos fármacos
Compostos Orgânicos/toxicidade
Extratos de Tecidos/química
Truta
[Mh] Termos MeSH secundário: Animais
Regiões Árticas
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Disruptores Endócrinos/toxicidade
Monitoramento Ambiental
Poluentes Ambientais/toxicidade
Feminino
Hepatócitos/metabolismo
Lagos/química
Limite de Detecção
Masculino
Noruega
Vitelogeninas/genética
Vitelogeninas/metabolismo
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Environmental Pollutants); 0 (Organic Chemicals); 0 (Tissue Extracts); 0 (Vitellogenins); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1357277


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[PMID]:28797129
[Au] Autor:Go YY; Kim SE; Cho GJ; Chae SW; Song JJ
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.
[Ti] Título:Differential effects of amnion and chorion membrane extracts on osteoblast-like cells due to the different growth factor composition of the extracts.
[So] Source:PLoS One;12(8):e0182716, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human amniotic membrane extracts contain numerous growth factors and bioactive substances. However, osteogenic effects of amnion and chorion membrane extracts (AME and CME, respectively) on osteoblasts are unclear. In this study, we explored the ability of AME and CME to promote the osteogenic differentiation of osteoblast-like MG-63 cells. MG-63 cells were cultured in osteogenic induction medium (OIM) with or without exogenous AME and CME. CME enhanced the osteogenic differentiation of MG-63 cells compared with AME, as indicated by increased mineralization; alkaline phosphatase activity; and mRNA expression of osteogenic marker genes encoding integrin-binding sialoprotein (IBSP), RUNX2, OSTERIX, and osteocalcin (OCN). Interestingly, AME and CME contained different combinations of osteogenesis-related growth factors, including basic fibroblast growth factor (bFGF), transforming growth factor beta-1 (TGFß-1), and epidermal growth factor (EGF), which differentially regulated the osteogenic differentiation of MG-63 cells. bFGF and TGFß-1 present in CME positively regulated the osteogenic differentiation of MG-63 cells, whereas EGF present in AME negatively regulated the differentiation of MG-63 cells. Moreover, exogenous treatment of EGF antagonized CME-induced mineralization of extracellular matrix on MG-63 cells. We compared the osteogenic efficacy of CME with that of BMP2, bFGF, and TGFß-1 alone or their combinations. We observed that CME greatly enhanced osteogenesis by providing a conductive environment for the differentiation of MG-63 cells. Together, our results indicated that human AME and CME exerted differential effects on osteogenesis because of the presence of different compositions of growth factors. In addition, our results highlighted a new possible strategy of using CME as a biocompatible therapeutic material for bone regeneration.
[Mh] Termos MeSH primário: Peptídeos e Proteínas de Sinalização Intercelular/fisiologia
Osteoblastos/fisiologia
[Mh] Termos MeSH secundário: Âmnio/química
Benzodioxóis/farmacologia
Linhagem Celular
Proliferação Celular
Forma Celular
Córion/química
Seres Humanos
Imidazóis/farmacologia
Peptídeos e Proteínas de Sinalização Intercelular/isolamento & purificação
Osteogênese
Piridinas/farmacologia
Pirróis/farmacologia
Extratos de Tecidos/isolamento & purificação
Extratos de Tecidos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride); 0 (Benzodioxoles); 0 (Imidazoles); 0 (Intercellular Signaling Peptides and Proteins); 0 (Pyridines); 0 (Pyrroles); 0 (SU 5402); 0 (Tissue Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182716


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[PMID]:28684912
[Au] Autor:Novotna B; Herynek V; Rossner P; Turnovcova K; Jendelova P
[Ad] Endereço:Department of Genetic Toxicology and Nanotoxicology, Institute of Experimental Medicine AS CR, v.v.i.
[Ti] Título:The effects of grafted mesenchymal stem cells labeled with iron oxide or cobalt-zinc-iron nanoparticles on the biological macromolecules of rat brain tissue extracts.
[So] Source:Int J Nanomedicine;12:4519-4526, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Rat mesenchymal stem cells (rMSCs) labeled with 1) poly-l-lysine-coated superparamagnetic iron oxide nanoparticles or 2) silica-coated cobalt-zinc-iron nanoparticles were implanted into the left brain hemisphere of rats, to assess their effects on the levels of oxidative damage to biological macromolecules in brain tissue. METHODS: Controls were implanted with unlabeled rMSCs. Animals were sacrificed 24 hours or 4 weeks after the treatment, and the implantation site along with the surrounding tissue was isolated from the brain. At the same intervals, parallel groups of animals were scanned in vivo by magnetic resonance imaging (MRI). The comet assay with enzymes of excision DNA repair (endonuclease III and formamidopyrimidine-DNA glycosylase) was used to analyze breaks and oxidative damage to DNA in the brain tissue. Oxidative damage to proteins and lipids was determined by measuring the levels of carbonyl groups and 15-F -isoprostane (enzyme-linked immunosorbent assay). MRI displayed implants of labeled cells as extensive hypointense areas in the brain tissue. In histological sections, the expression of glial fibrillary acidic protein and CD68 was analyzed to detect astrogliosis and inflammatory response. RESULTS: Both contrast labels caused a similar response in the T -weighted magnetic resonance (MR) image and the signal was clearly visible within 4 weeks after implantation of rMSCs. No increase of oxidative damage to DNA, lipids, or proteins over the control values was detected in any sample of brain tissue from the treated animals. Also, immunohistochemistry did not indicate any serious tissue impairment around the graft. CONCLUSION: Both tested types of nanoparticles appear to be prospective and safe labels for tracking the transplanted cells by MR.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Transplante de Células-Tronco Mesenquimais
Células Mesenquimais Estromais/química
Nanopartículas Metálicas/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Cobalto/química
Ensaio de Imunoadsorção Enzimática
Compostos Férricos/química
Ferro/química
Isoprostanos/análise
Isoprostanos/metabolismo
Imagem por Ressonância Magnética/métodos
Masculino
Nanopartículas Metálicas/química
Nanopartículas Metálicas/toxicidade
Estudos Prospectivos
Ratos Endogâmicos Lew
Dióxido de Silício/química
Extratos de Tecidos
Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (15-F2t-isoprostane); 0 (Ferric Compounds); 0 (Isoprostanes); 0 (Tissue Extracts); 1K09F3G675 (ferric oxide); 3G0H8C9362 (Cobalt); 7631-86-9 (Silicon Dioxide); E1UOL152H7 (Iron); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S133156


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[PMID]:28427519
[Au] Autor:Maia MC; Hansen AR
[Ad] Endereço:Department of Medical Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), Av. Dr Arnaldo, 251, Cerqueira César, CEP 01246-000, São Paulo, Brazil. Electronic address: mcaitano@icloud.com.
[Ti] Título:A comprehensive review of immunotherapies in prostate cancer.
[So] Source:Crit Rev Oncol Hematol;113:292-303, 2017 May.
[Is] ISSN:1879-0461
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Prostate cancer is the second most common malignant neoplasm in men worldwide and the fifth cause of cancer-related death. Although multiple new agents have been approved for metastatic castration resistant prostate cancer over the last decade, it is still an incurable disease. New strategies to improve cancer control are needed and agents targeting the immune system have shown encouraging results in many tumor types. Despite being attractive for immunotherapies due to the expression of various tumor associated antigens, the microenvironment in prostate cancer is relatively immunosuppressive and may be responsible for the failures of various agents targeting the immune system in this disease. To date, sipuleucel-T is the only immunotherapy that has shown significant clinical efficacy in this setting, although the high cost and potential trial flaws have precluded its widespread incorporation into clinical practice. Issues with patient selection and trial design may have contributed to the multiple failures of immunotherapy in prostate cancer and provides an opportunity to tailor future studies to evaluate these agents more accurately. We have reviewed all the completed immune therapy trials in prostate cancer and highlight important considerations for the next generation of clinical trials.
[Mh] Termos MeSH primário: Imunoterapia
Neoplasias da Próstata/terapia
[Mh] Termos MeSH secundário: Antígeno CTLA-4/antagonistas & inibidores
Vacinas Anticâncer/uso terapêutico
Ensaios Clínicos como Assunto
Seres Humanos
Imunoterapia/métodos
Masculino
Neoplasias da Próstata/imunologia
Neoplasias da Próstata/patologia
Extratos de Tecidos/uso terapêutico
Microambiente Tumoral
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (CTLA-4 Antigen); 0 (Cancer Vaccines); 0 (Tissue Extracts); 8Q622VDR18 (sipuleucel-T)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


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[PMID]:28398209
[Au] Autor:Mashima E; Sawada Y; Yamaguchi T; Ohmori S; Haruyama S; Yoshioka M; Okada E; Nakamura M
[Ad] Endereço:Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
[Ti] Título:Eosinophilic Cellulitis Possibly Due to Mosquito Bite With High IL-5 Production.
[So] Source:J Investig Allergol Clin Immunol;27(2):149-150, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Celulite (Flegmão)/imunologia
Culicidae/imunologia
Eosinofilia/imunologia
Mordeduras e Picadas de Insetos/imunologia
Interleucina-5/imunologia
Leucócitos Mononucleares/imunologia
Pele/imunologia
[Mh] Termos MeSH secundário: Administração Cutânea
Idoso de 80 Anos ou mais
Animais
Biópsia
Células Cultivadas
Celulite (Flegmão)/diagnóstico
Celulite (Flegmão)/tratamento farmacológico
Celulite (Flegmão)/metabolismo
Eosinofilia/diagnóstico
Eosinofilia/tratamento farmacológico
Eosinofilia/metabolismo
Glucocorticoides/administração & dosagem
Seres Humanos
Mordeduras e Picadas de Insetos/diagnóstico
Mordeduras e Picadas de Insetos/tratamento farmacológico
Mordeduras e Picadas de Insetos/metabolismo
Interleucina-5/metabolismo
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/metabolismo
Masculino
Glândulas Salivares/imunologia
Pele/efeitos dos fármacos
Pele/metabolismo
Extratos de Tecidos/imunologia
Resultado do Tratamento
Regulação para Cima
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (IL5 protein, human); 0 (Interleukin-5); 0 (Tissue Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0142


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[PMID]:28361161
[Au] Autor:Fung FY; Linn YC
[Ad] Endereço:Traditional Medicine Information Service, Department of Pharmacy, Singapore General Hospital, Singapore.
[Ti] Título:Steroids in traditional Chinese medicine: what is the evidence?
[So] Source:Singapore Med J;58(3):115-120, 2017 Mar.
[Is] ISSN:0037-5675
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Local healthcare providers often question the possible steroidal activity of traditional Chinese medicine (TCM) herbs or herbal products and implicate them as a cause for adrenal insufficiency or Cushing's syndrome in patients with a history of TCM intake. We conducted a comprehensive database search for evidence of potential glucocorticoid, mineralocorticoid, androgenic or oestrogenic activity of herbs or herbal products. Overall, there are not many herbs whose steroidal activity is well established; among these, most cases were based on preclinical studies. Liquorice root may cause pseudoaldosteronism through interference with the steroidogenesis pathway. Although ginseng and cordyceps have some in vitro glucocorticoid activities, the corroborating clinical data is lacking. Deer musk and deer antler contain androgenic steroids, while epimedium has oestrogenic activity. On the other hand, adulteration of herbal products with exogenous glucocorticoids is a recurrent problem encountered locally in illegal products masquerading as TCM. Healthcare providers should stay vigilant and report any suspicion to the relevant authorities for further investigations.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/análise
Medicina Tradicional Chinesa/efeitos adversos
Esteroides/análise
[Mh] Termos MeSH secundário: Androgênios/análise
Animais
Cordyceps
Bases de Dados Factuais
Cervos
Medicamentos de Ervas Chinesas/efeitos adversos
Epimedium
Estrogênios/análise
Ácidos Graxos Monoinsaturados
Glucocorticoides/análise
Glycyrrhiza uralensis
Seres Humanos
Mineralocorticoides/análise
Panax
Preparações de Plantas/análise
Risco
Singapura
Esteroides/efeitos adversos
Extratos de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Androgens); 0 (Drugs, Chinese Herbal); 0 (Estrogens); 0 (Fatty Acids, Monounsaturated); 0 (Glucocorticoids); 0 (Mineralocorticoids); 0 (Plant Preparations); 0 (Steroids); 0 (Tissue Extracts); 0 (lu rong); 095I377U8F (musk)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.11622/smedj.2017016


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[PMID]:28346717
[Au] Autor:Bhagavathula N; Meedidoddi V; Bourque S; Vimaladevi R; Kesavakurup S; Selvadurai D; Shrivastava S; Krishnappa C
[Ad] Endereço:Department of Applied Zoology, School of Biological Sciences, Kuvempu University, Shankaraghatta, Shivamogga, Karnataka, India.
[Ti] Título:Characterization of two novel antimicrobial peptides from the cuticular extracts of the ant Trichomyrmex criniceps (Mayr), (Hymenoptera: Formicidae).
[So] Source:Arch Insect Biochem Physiol;94(4), 2017 Apr.
[Is] ISSN:1520-6327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antimicrobial peptides (AMPs) from cuticular extracts of worker ants of Trichomyrmex criniceps (Mayr, Hymenoptera: Formicidae) were isolated and evaluated for their antimicrobial activity. Eight peptides ranging in mass from 804.42 to 1541.04 Da were characterized using a combination of analytical and bioinformatics approach. All the eight peptides were novel with no similarity to any of the AMPs archived in the Antimicrobial Peptide Database. Two of the eight novel peptides, the smallest and the largest by mass were named Crinicepsin-1 and Crinicepsin-2 and were chemically synthesized by solid phase peptide synthesis. The two synthetic peptides had antibacterial and weak hemolytic activity.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Peptídeos Catiônicos Antimicrobianos/farmacologia
Formigas/química
Proteínas de Insetos/farmacologia
Oligopeptídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/síntese química
Antibacterianos/isolamento & purificação
Peptídeos Catiônicos Antimicrobianos/síntese química
Peptídeos Catiônicos Antimicrobianos/isolamento & purificação
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Hemólise
Seres Humanos
Proteínas de Insetos/síntese química
Proteínas de Insetos/isolamento & purificação
Oligopeptídeos/síntese química
Oligopeptídeos/isolamento & purificação
Extratos de Tecidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antimicrobial Cationic Peptides); 0 (Insect Proteins); 0 (Oligopeptides); 0 (Tissue Extracts); 0 (crinicepsin-1); 0 (crinicepsin-2)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1002/arch.21381



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