Base de dados : MEDLINE
Pesquisa : D20.888.033 [Categoria DeCS]
Referências encontradas : 385 [refinar]
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[PMID]:28421441
[Au] Autor:Kryukova EV; Lebedev DS; Ivanov IA; Ivanov DA; Starkov VG; Tsetlin VI; Utkin YN
[Ad] Endereço:Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. evkr@mail.ru.
[Ti] Título:N-methyl serotonin analogues from the Bufo bufo toad venom interact efficiently with the α7 nicotinic acetylcholine receptors.
[So] Source:Dokl Biochem Biophys;472(1):52-55, 2017 Jan.
[Is] ISSN:1608-3091
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Two low-molecular-weight compounds were isolated from the parotid gland secret of the toad Bufo bufo, which by absorption spectra and HPLC-MS/MS chromatography data correspond to di- and trimethyl derivatives of serotonin (5-hydorxytryptamine): bufotenine (confirmed by counter synthesis) and bufotenidine (5-HTQ). In experiments on competitive radioligand binding, these compounds showed a higher affinity and selectivity for neuronal α7 nicotinic acetylcholine receptors compared with the muscular cholinergic receptors. The most efficient compound in terms of binding value was bufotenine, the efficiency of 5-HTQ was an order of magnitude lower, and the minimal activity was exhibited by serotonin.
[Mh] Termos MeSH primário: Venenos de Anfíbios/farmacologia
Serotonina/análogos & derivados
Receptor Nicotínico de Acetilcolina alfa7/metabolismo
[Mh] Termos MeSH secundário: Venenos de Anfíbios/química
Animais
Bufo bufo
Linhagem Celular
Ligantes
Ligação Proteica
Ratos
Receptor Nicotínico de Acetilcolina alfa7/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amphibian Venoms); 0 (Ligands); 0 (alpha7 Nicotinic Acetylcholine Receptor); 333DO1RDJY (Serotonin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1134/S1607672917010136


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[PMID]:28249803
[Au] Autor:Cavalcante ID; Antoniazzi MM; Jared C; Pires OR; Sciani JM; Pimenta DC
[Ad] Endereço:Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, SP, 05503-900 Brazil.
[Ti] Título:Venomics analyses of the skin secretion of Dermatonotus muelleri: Preliminary proteomic and metabolomic profiling.
[So] Source:Toxicon;130:127-135, 2017 May.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dermatonotus muelleri is the sole species of the Dermatonotus genus and inhabits Argentina, Bolivia, Brazil and Paraguay. This animal exhibits an explosive reproductive behavior during the Southern spring months, which lasts only for five days. Moreover, this animal displays specific adaptations to the habitat resulting in the energy conservation needed during either the intense reproduction period or times of estivation. During dry seasons and/or food shortages D. muelleri can survive because its food specialization and ability to dig an underground chamber for protection. Few literature is available on this amphibian and no biochemical characterization has ever been performed on the animal's skin secretion. This work, on the other hand, presents for the first time a venomic analysis of the major components present in the skin secretion of this microhylid. The crude skin secretion was obtained my mechanical stimulation and was analyzed according to one major criterion: >10 kDa or <10 kDa. The high molecular mass fraction was subjected to typical gel-based proteomic processing whereas the low molecular mass fraction was analyzed by liquid chromatography, mass spectrometry and nuclear magnetic resonance (NMR), yielding an overall 'venomics' approach. No classical/evident toxin was detected, but peptidases (metallo and serino) and structural proteins could be identified. In the low molecular mass fraction no peptides were detected, as well as no typical alkaloid or steroid. On the other hand, the amino acid tryptophan could be identified and a typical sugar spectrum was obtained in the NMR analyses. Altogether these findings point out to the fact that D. muelleri skin secretion is unique and the molecular arsenal present herein is yet to be explored; therefore, this venomics study is only the beginning.
[Mh] Termos MeSH primário: Proteínas de Anfíbios/química
Venenos de Anfíbios/química
Anuros/metabolismo
Pele/secreção
[Mh] Termos MeSH secundário: Proteínas de Anfíbios/farmacologia
Proteínas de Anfíbios/fisiologia
Venenos de Anfíbios/metabolismo
Venenos de Anfíbios/farmacologia
Animais
Cromatografia Líquida de Alta Pressão
Escherichia coli/efeitos dos fármacos
Espectrometria de Massas
Metabolômica
Testes de Sensibilidade Microbiana
Micrococcus luteus/efeitos dos fármacos
Ressonância Magnética Nuclear Biomolecular
Proteômica
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amphibian Proteins); 0 (Amphibian Venoms)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE


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[PMID]:28235580
[Au] Autor:Mailho-Fontana PL; Antoniazzi MM; Rodrigues I; Sciani JM; Pimenta DC; Brodie ED; Rodrigues MT; Jared C
[Ad] Endereço:Laboratory of Cell Biology, Instituto Butantan, São Paulo, Brazil.
[Ti] Título:Parotoid, radial, and tibial macroglands of the frog Odontophrynus cultripes: Differences and similarities with toads.
[So] Source:Toxicon;129:123-133, 2017 Apr.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anuran integument is characterized by the presence of glands, some of which are responsible for toxin production. In some species these glands accumulate in parts of the body strategically located against predators, forming structures known as macroglands. This is the case for parotoid macroglands, on the dorsum of the head, tibial macroglands, on the rear limbs, and radial macroglands, on the forelimbs of toads and some other anurans. The toad Rhinella jimi, for example, simultaneously displays all three types of macroglands, which is unusual even among bufonids. Interestingly, considering the phylogenetic distance, the frog Odontophrynus cultripes (Odontophrynidae) also presents these three macroglandular types. In this study we analyze the morphology of O. cultripes macroglands and the chemical composition of their poison using an interdisciplinary approach. In this species, the parotoid, tibial, and radial macroglands consist of aggregates of elongated and juxtaposed poison glands, arranged in a honeycomb style, very similar to that of toads. Comparative analysis of these three macrogland types shows significant differences in both the morphology of secretory granules and biochemical composition. The present work on O. cultripes contributes to the evidence that amphibians, or at least anurans, share a basic design for all cutaneous glandular accumulations. The determinant factor for macroglandular formation may be the selective pressure for defense against predators.
[Mh] Termos MeSH primário: Anuros/fisiologia
Bufonidae/fisiologia
Glândula Parótida/anatomia & histologia
[Mh] Termos MeSH secundário: Venenos de Anfíbios/química
Venenos de Anfíbios/secreção
Animais
Anuros/classificação
Comportamento Animal
Bufonidae/classificação
Feminino
Masculino
Glândula Parótida/secreção
Glândula Parótida/ultraestrutura
Filogenia
Pele/anatomia & histologia
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amphibian Venoms)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


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[PMID]:28235032
[Au] Autor:Krings M; Klein B; Heneka MJ; Rödder D
[Ad] Endereço:Department of Herpetology, Zoologisches Forschungsmuseum Alexander Koenig, Bonn, Germany.
[Ti] Título:Morphological comparison of five species of poison dart frogs of the genus Ranitomeya (Anura: Dendrobatidae) including the skeleton, the muscle system and inner organs.
[So] Source:PLoS One;12(2):e0171669, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The morphology of larvae stages of most amphibians are often completely different than in adults. Tadpole descriptions have historically been based on external characters like morphometrics, color pattern and oral disc structure. Other papers described anatomical details by the use of dissections. The increase in micro-CT scanning technology provides an opportunity to quantify and describe in detail internal characters like skeleton, musculature and organs. To date, no such tadpole descriptions exist for the well-studied Neotropical poison dart frog genus Ranitomeya (Anura: Dendrobatidae). Here we provide descriptions of the internal skeletal, musculature and organ structures of five Ranitomeya species and then provide morphological comparisons. Contrary to previous observations, closely related species display several morphological differences. For example, we observed considerable variation in chondrocranial characters, the extent of cranial ossifications, the appearance of some cranial muscles and the arrangement of inner organs. Further studies on the tadpole morphology of more species of Ranitomeya and other dendrobatid genera are needed to enable us to understand the complete morphological variation in this group.
[Mh] Termos MeSH primário: Anuros/anatomia & histologia
Osso e Ossos/anatomia & histologia
Larva/anatomia & histologia
Músculos/anatomia & histologia
[Mh] Termos MeSH secundário: Venenos de Anfíbios/química
Animais
Anuros/classificação
Anuros/fisiologia
Osso e Ossos/fisiologia
Coração/anatomia & histologia
Coração/fisiologia
Larva/classificação
Larva/fisiologia
Fígado/anatomia & histologia
Fígado/fisiologia
Pulmão/anatomia & histologia
Pulmão/fisiologia
Músculos/fisiologia
Filogenia
Coloração e Rotulagem
Fixação de Tecidos
Microtomografia por Raio-X
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amphibian Venoms)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0171669


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[PMID]:28131913
[Au] Autor:Schmeda-Hirschmann G; Gomez CV; Rojas de Arias A; Burgos-Edwards A; Alfonso J; Rolon M; Brusquetti F; Netto F; Urra FA; Cárdenas C
[Ad] Endereço:Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, 3460000 Talca, Chile. Electronic address: schmeda@utalca.cl.
[Ti] Título:The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells.
[So] Source:J Ethnopharmacol;199:106-118, 2017 Mar 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Toads belonging to genus Rhinella are used in Paraguayan traditional medicine to treat cancer and skin infections. AIM OF THE STUDY: The objective of the study was to determine the composition of venoms obtained from three different Paraguayan Rhinella species, to establish the constituents of a preparation sold in the capital city of Paraguay to treat cancer as containing the toad as ingredient, to establish the effect of the most active Rhinella schneideri venom on the cell cycle using human breast cancer cells and to assess the antiprotozoal activity of the venoms. METHODS: The venom obtained from the toads parotid glands was analyzed by HPLC-MS-MS. The preparation sold in the capital city of Paraguay to treat cancer that is advertised as made using the toad was analyzed by HPLC-MS-MS. The effect of the R. schneideri venom and the preparation was investigated on human breast cancer cells. The antiprotozoal activity was evaluated on Leishmania braziliensis, L. infantum and murine macrophages. RESULTS: From the venoms of R. ornata, R. schneideri and R. scitula, some 40 compounds were identified by spectroscopic and spectrometric means. Several minor constituents are reported for the first time. The preparation sold as made from the toad did not contained bufadienolides or compounds that can be associated with the toad but plant compounds, mainly phenolics and flavonoids. The venom showed activity on human breast cancer cells and modified the cell cycle proliferation. The antiprotozoal effect was higher for the R. schneideri venom and can be related to the composition and relative ratio of constituents compared with R. ornata and R. scitula. CONCLUSIONS: The preparation sold in the capital city of Paraguay as containing the toad venom, used popularly to treat cancer did not contain the toad venom constituents. Consistent with this, this preparation was inactive on proliferation of human breast cancer cells. In contrast, the toad venoms of Rhinella species altered the cell cycle progression, affecting the proliferation of malignant cells. The findings suggest that care should be taken with the providers of the preparation and that the crude drug present a strong activity towards human breast cancer cell lines. The antiprotozoal effect of the R. schneideri venom was moderate while the venom of R. ornata was devoid of activity and that of R. scitula was active at very high concentration.
[Mh] Termos MeSH primário: Venenos de Anfíbios/isolamento & purificação
Venenos de Anfíbios/farmacologia
Neoplasias da Mama/patologia
Proliferação Celular/efeitos dos fármacos
Medicina Tradicional/métodos
[Mh] Termos MeSH secundário: Venenos de Anfíbios/química
Animais
Bufo marinus
Linhagem Celular Tumoral
Proliferação Celular/fisiologia
Células Cultivadas
Feminino
Seres Humanos
Macrófagos/efeitos dos fármacos
Macrófagos/fisiologia
Camundongos
Paraguai
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amphibian Venoms)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


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[PMID]:28089841
[Au] Autor:Tarvin RD; Powell EA; Santos JC; Ron SR; Cannatella DC
[Ad] Endereço:Department of Integrative Biology and Biodiversity Collections, University of Texas, Austin, TX, United States. Electronic address: rdtarvin@gmail.com.
[Ti] Título:The birth of aposematism: High phenotypic divergence and low genetic diversity in a young clade of poison frogs.
[So] Source:Mol Phylogenet Evol;109:283-295, 2017 Apr.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rapid radiation coupled with low genetic divergence often hinders species delimitation and phylogeny estimation even if putative species are phenotypically distinct. Some aposematic species, such as poison frogs (Dendrobatidae), have high levels of intraspecific color polymorphism, which can lead to overestimation of species when phenotypic divergence primarily guides species delimitation. We explored this possibility in the youngest origin of aposematism (3-7 MYA) in poison frogs, Epipedobates, by comparing genetic divergence with color and acoustic divergence. We found low genetic divergence (2.6% in the 16S gene) despite substantial differences in color and acoustic signals. While chemical defense is inferred to have evolved in the ancestor of Epipedobates, aposematic coloration evolved at least twice or was lost once in Epipedobates, suggesting that it is evolutionarily labile. We inferred at least one event of introgression between two cryptically colored species with adjacent ranges (E. boulengeri and E. machalilla). We also find evidence for peripheral isolation resulting in phenotypic divergence and potential speciation of the aposematic E. tricolor from the non-aposematic E. machalilla. However, we were unable to estimate a well-supported species tree or delimit species using multispecies coalescent models. We attribute this failure to factors associated with recent speciation including mitochondrial introgression, incomplete lineage sorting, and too few informative molecular characters. We suggest that species delimitation within young aposematic lineages such as Epipedobates will require genome-level molecular studies. We caution against relying solely on DNA barcoding for species delimitation or identification and highlight the value of phenotypic divergence and natural history in delimiting species.
[Mh] Termos MeSH primário: Anuros/classificação
Mimetismo Biológico
Variação Genética
[Mh] Termos MeSH secundário: Venenos de Anfíbios
Animais
Anuros/anatomia & histologia
Evolução Biológica
Mimetismo Biológico/genética
DNA Mitocondrial
Especiação Genética
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amphibian Venoms); 0 (DNA, Mitochondrial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


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[PMID]:28081155
[Au] Autor:Wei X; Si N; Zhang Y; Zhao H; Yang J; Wang H; Wang L; Han L; Bian B
[Ad] Endereço:Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences, Beijing, China.
[Ti] Título:Evaluation of Bufadienolides as the Main Antitumor Components in Cinobufacin Injection for Liver and Gastric Cancer Therapy.
[So] Source:PLoS One;12(1):e0169141, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cinobufacin injection, also known as huachansu, is a preparation form of Cinobufacini made from Cinobufacin extract liquid. Despite that Cinobufacin injection is shown to shrink liver and gastric tumors, improving patient survival and life quality, the effective components in Cinobufacin remain elusive. In this study, we aim to screen antitumor components from Cinobufacin injection to elucidate the most effective antitumor components for treatment of liver and gastric cancers. MATERIALS AND METHODS: High performance liquid chromatography (HPLC) and LC-MS/MS analysis were used to separate and determine the components in Cinobufacin injection. Inhibition rates of various components in Cinobufacin injection on liver and gastric cancer cells were determined with MTT assay; Hepatocellular carcinoma and gastric cancer models were used to assess the antitumor effect of the compounds in vivo. RESULTS: The major constituents in Cinobufacin injection include peptides, nucleic acids, tryptamines and bufotalins. MTT assay revealed that bufadienolides had the best antitumor activity, with peptides being the second most effective components. Bufadienolides showed significant inhibition rates on gastric and hepatocellular tumour growth in vivo. CONCLUSION: Bufadienolides are the most effective components in Cinobufacini injection for the treatment of liver and gastric cancers. This discovery can greatly facilitate further research in improving the therapeutic effects of Cinobufacin injection, meanwhile reducing its adverse reaction.
[Mh] Termos MeSH primário: Venenos de Anfíbios/farmacologia
Antineoplásicos/farmacologia
Bufanolídeos/farmacologia
Neoplasias Experimentais/tratamento farmacológico
[Mh] Termos MeSH secundário: Venenos de Anfíbios/química
Animais
Antineoplásicos/química
Bufanolídeos/química
Células Hep G2
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos ICR
Camundongos Nus
Neoplasias Experimentais/metabolismo
Neoplasias Experimentais/patologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amphibian Venoms); 0 (Antineoplastic Agents); 0 (Bufanolides); 0 (huachansu)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169141


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[PMID]:28069354
[Au] Autor:Sousa LQ; Machado KD; Oliveira SF; Araújo LD; Monção-Filho ED; Melo-Cavalcante AA; Vieira-Júnior GM; Ferreira PM
[Ad] Endereço:Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, 64.049-550, Teresina, Piauí, Brazil.
[Ti] Título:Bufadienolides from amphibians: A promising source of anticancer prototypes for radical innovation, apoptosis triggering and Na /K -ATPase inhibition.
[So] Source:Toxicon;127:63-76, 2017 Mar 01.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Amphibians present pharmacologically active aliphatic, aromatic and heterocyclic molecules in their skin as defense against microorganisms, predators and infections, such as steroids, alkaloids, biogenic amines, guanidine derivatives, proteins and peptides. Based on the discovered bioactive potential of bufadienolides, this work reviewed the contribution of amphibians, especially from members of Bufonidae family, as source of new cytotoxic and antitumor molecules, highlighting the mechanisms responsible for such amazing biological potentialities. Bufonidae species produce bufadienolides related to cholesterol through the mevalonate-independent and acidic bile acid pathways as polyhydroxy steroids with 24 carbons. In vitro antitumor studies performed with skin secretions and its isolated components (specially marinobufagin, telocinobufagin, bufalin and cinobufagin) from Rhinella, Bufo and Rhaebo species have shown remarkable biological action on hematological, solid, sensitive and/or resistant human tumor cell lines. Some compounds revealed higher selectivity against neoplastic lines when compared to dividing normal cells and some molecules may biochemically associate with Na /K -ATPase and there is structural similarity to the digoxin- and ouabain-Na /K -ATPase complexs, implying a similar mechanism of the Na /K -ATPase inhibition by cardenolides and bufadienolides. Some bufadienolides also reduce levels of antiapoptotic proteins and DNA synthesis, cause morphological changes (chromatin condensation, nuclear fragmentation, cytoplasm shrinkage, cytoplasmic vacuoles, stickiness reduction and apoptotic bodies), cell cycle arrest in G /M or S phases, mitochondrial depolarization, PARP [poly (ADPribose) polymerase] and Bid cleavages, cytochrome c release, activation of Bax and caspases (-3, -9, -8 and -10), increased expression of the Fas-Associated protein with Death Domain (FADD), induce topoisomerase II inhibition, DNA fragmentation, cell differentiation, angiogenesis inhibition, multidrug resistance reversion, and also regulate immune responses. Then, bufadienolides isolated from amphibians, some of them at risk of extinction, emerge as a natural class of incredible chemical biodiversity, has moderate selectivity against human tumor cells and weak activity on murine cells, probably due to structural differences between subunits of human and mice Na /K -ATPases.
[Mh] Termos MeSH primário: Venenos de Anfíbios/farmacologia
Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Bufanolídeos/farmacologia
ATPase Trocadora de Sódio-Potássio/antagonistas & inibidores
[Mh] Termos MeSH secundário: Venenos de Anfíbios/química
Anfíbios
Animais
Antineoplásicos/química
Bufanolídeos/química
Bufonidae
Linhagem Celular Tumoral
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amphibian Venoms); 0 (Antineoplastic Agents); 0 (Bufanolides); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE


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[PMID]:28034659
[Au] Autor:Rodríguez C; Rollins-Smith L; Ibáñez R; Durant-Archibold AA; Gutiérrez M
[Ad] Endereço:Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones, Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), City of Knowledge, Panama 0843-01103, Republic of Panama; Department of Biotechnology, Acharya Nagarjuna University, Guntur 522510, India.
[Ti] Título:Toxins and pharmacologically active compounds from species of the family Bufonidae (Amphibia, Anura).
[So] Source:J Ethnopharmacol;198:235-254, 2017 Feb 23.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Among amphibians, 15 of the 47 species reported to be used in traditional medicines belong to the family Bufonidae, which demonstrates their potential in pharmacological and natural products research. For example, Asian and American tribes use the skin and the parotoid gland secretions of some common toads in the treatment of hemorrhages, bites and stings from venomous animals, skin and stomach disorders, as well as several types of cancers. OVERARCHING OBJECTIVE: In addition to reviewing the occurrence of chemical constituents present in the family Bufonidae, the cytotoxic and biomedical potential of the active compounds produced by different taxa are presented. METHODOLOGY: Available information on bioactive compounds isolated from species of the family Bufonidae was obtained from ACS Publications, Google, Google Scholar, Pubmed, Sciendirect and Springer. Papers written in Chinese, English, German and Spanish were considered. RESULTS: Recent reports show more than 30% of amphibians are in decline and some of bufonid species are considered to be extinct. For centuries, bufonids have been used as traditional folk remedies to treat allergies, inflammation, cancer, infections and other ailments, highlighting their importance as a prolific source for novel drugs and therapies. Toxins and bioactive chemical constituents from skin and parotid gland secretions of bufonid species can be grouped in five families, the guanidine alkaloids isolated and characterized from Atelopus, the lipophilic alkaloids isolated from Melanophryniscus, the indole alkaloids and bufadienolides known to be synthesized by species of bufonids, and peptides and proteins isolated from the skin and gastrointestinal extracts of some common toads. Overall, the bioactive secretions of this family of anurans may have antimicrobial, protease inhibitor and anticancer properties, as well as being active at the neuromuscular level. CONCLUSION: In this article, the traditional uses, toxicity and pharmacological potential of chemical compounds from bufonids have been summarized. In spite of being reported to be used to treat several diseases, neither extracts nor metabolites from bufonids have been tested in such illness like acne, osteoporosis, arthritis and other illnesses. However, the cytotoxicity of these metabolites needs to be evaluated on adequate animal models due to the limited conditions of in vitro assays. Novel qualitative and quantitative tools based on MS spectrometry and Nuclear Magnetic Resonance spectroscopy is now available to study the complex secretions of bufonids.
[Mh] Termos MeSH primário: Venenos de Anfíbios/isolamento & purificação
Bufonidae/metabolismo
Medicina Tradicional/métodos
[Mh] Termos MeSH secundário: Animais
Produtos Biológicos/isolamento & purificação
Produtos Biológicos/farmacologia
Produtos Biológicos/toxicidade
Seres Humanos
Espectroscopia de Ressonância Magnética/métodos
Espectrometria de Massas/métodos
Especificidade da Espécie
Toxinas Biológicas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amphibian Venoms); 0 (Biological Products); 0 (Toxins, Biological)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


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[PMID]:27784460
[Au] Autor:Jiang Y; Wu LB; Shen LP; Zhang P; Jiang WJ; Tian JH; Liu LS
[Ad] Endereço:Department of Oncology, Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
[Ti] Título:[Effect of traditional Chinese medicine treatment as maintenance therapy on regulating the serum concentration of sCTLA-4 in patients with advanced non-small-cell lung cancer and its relationship with prognosis].
[So] Source:Zhonghua Zhong Liu Za Zhi;38(10):757-762, 2016 Oct 23.
[Is] ISSN:0253-3766
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To evaluate the effect of traditional Chinese medicine (TCM) treatment as maintenance therapy on regulating the serum concentration of soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) in patients with advanced non-small-cell lung cancer (NSCLC) and the relationship between sCTLA-4 and time to progression (TTP). This study was conducted as a prospective, randomized, controlled trial. 64 non-progressive patients who responded to initial therapy were randomized 1∶1 to the TCM arm (treated with cinobufacini injection, herbal decoction and Chinese acupoint application, =32) or to the chemotherapy arm ( =32). Each cycle was 21 days. Cycles were repeated until disease progression, unacceptable toxicity, or until the patient requested therapy discontinuation.The serum concentration of sCTLA-4 was detected by enzyme linked immunosorbent assay (ELISA) in the 64 patients with advanced NSCLC before and after two cycles of maintenance treatment. Cox regression was used to analyze the relative ratio for the risk of disease progression. After 2 cycles of maintenance TCM treatment, the serum concentration of sCTLA-4 in patients with advanced NSCLC was (12.77±2.37 pg/ml), significantly lower than that before treatment (40.30±10.75)( =0.013). After 2 cycles of maintenance chemotherapy, the serum concentration of sCTLA-4 was higher than that before treatment, but was not significantly different (44.48±10.12 vs. 46.64±11.21 pg/ml, =0.612). After 2 cycles of maintenance treatment, TCM treatment can significantly bring down the serum concentration of sCTLA-4 compared to chemotherapy (12.77±2.37 vs. 46.64±11.21 pg/ml, =0.004). The multivariate analysis indicated that sCTLA-4 levels and treatment regimen were independent prognostic factors for TTP ( <0.05 for both). Regulating the serum concentration of sCTLA-4 may be one of the mechanisms of TCM maintenance treatment of NSCLC. Trial registration Chinese Clinical Trial Register, ChiCTR-TRC-10001017.
[Mh] Termos MeSH primário: Venenos de Anfíbios/uso terapêutico
Antígeno CTLA-4/sangue
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Neoplasias Pulmonares/tratamento farmacológico
Quimioterapia de Manutenção/métodos
Medicina Tradicional Chinesa
[Mh] Termos MeSH secundário: Pontos de Acupuntura
Idoso
Antígenos de Neoplasias/sangue
Carcinoma Pulmonar de Células não Pequenas/sangue
Terapia Combinada/métodos
Progressão da Doença
Medicamentos de Ervas Chinesas
Feminino
Seres Humanos
Neoplasias Pulmonares/sangue
Masculino
Meia-Idade
Proteínas de Neoplasias/sangue
Fitoterapia
Prognóstico
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Amphibian Venoms); 0 (Antigens, Neoplasm); 0 (CTLA-4 Antigen); 0 (CTLA4 protein, human); 0 (Drugs, Chinese Herbal); 0 (Neoplasm Proteins); 0 (huachansu)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2016.10.009



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