Base de dados : MEDLINE
Pesquisa : D23 [Categoria DeCS]
Referências encontradas : 5281 [refinar]
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  1 / 5281 MEDLINE  
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[PMID]:28450275
[Au] Autor:Casadevall N; Flossmann O; Hunt D
[Ad] Endereço:Hôpital Sainte-Antoine, Paris, France.
[Ti] Título:Evolution of biological agents: how established drugs can become less safe.
[So] Source:BMJ;357:j1707, 2017 04 27.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Fatores Biológicos
Segurança do Paciente
[Mh] Termos MeSH secundário: Fatores Biológicos/efeitos adversos
Aprovação de Drogas
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Factors)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j1707


  2 / 5281 MEDLINE  
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[PMID]:29101486
[Au] Autor:Sunil Kumar D; Janakiram P; Murali Krishna Kumar M; Krishna Geetha G
[Ad] Endereço:Department of Marine Living Resources, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India.
[Ti] Título:Inhibitory activity of bio-active compounds isolated from Anadara granosa in shrimp health management.
[So] Source:World J Microbiol Biotechnol;33(11):207, 2017 Nov 03.
[Is] ISSN:1573-0972
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The crude extract isolated from the visceral mass of Anadara granosa, an intertidal bivalve mollusc was tested for inhibitory activity against pathogenic bacteria of the shrimp and fish viz. Vibrio harveyi and Staphylococcus aureus respectively by agar well diffusion and contact bioautography methods. Maximum inhibitory activity was shown against V. harveyi by methanol and chloroform (9:1) extract. Twelve fractions (1-12) could be separated from the crude extract through column chromatography. Five out of twelve fractions (7, 8, 9, 10, and 11) showed antibacterial activity and they were further run on column chromatography for purity. The fraction no. 9 showed highest antibacterial activity among the five and was subjected to NMR for the proton, C and H -H correlation, IR and mass spectral analysis for structural elucidation. Structure of the compound isolated from fraction no: 9 was determined as 1-(((2Z, 4Z)-dodeca-2,4-dienoyl)oxy)-3-hydroxypropan-2-yl tetradecanoate.
[Mh] Termos MeSH primário: Antibacterianos/química
Antibacterianos/farmacologia
Arcidae/química
Artemia/microbiologia
Fatores Biológicos/química
Fatores Biológicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Metanol/química
Testes de Sensibilidade Microbiana
Staphylococcus aureus/efeitos dos fármacos
Vibrio/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Biological Factors); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171105
[St] Status:MEDLINE
[do] DOI:10.1007/s11274-017-2340-4


  3 / 5281 MEDLINE  
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[PMID]:29052873
[Au] Autor:Balak DMW
[Ad] Endereço:Department of Dermatology, Erasmus MC, University Medical Center, Burg. s'Jacobplein 51, 3015 CA, Rotterdam, the Netherlands.
[Ti] Título:First-line systemic treatment of psoriasis: staying conventional or going biologic?
[So] Source:Br J Dermatol;177(4):897-898, 2017 10.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Fármacos Dermatológicos
Psoríase
[Mh] Termos MeSH secundário: Fatores Biológicos
Produtos Biológicos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Biological Factors); 0 (Biological Products); 0 (Dermatologic Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15885


  4 / 5281 MEDLINE  
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[PMID]:28940268
[Au] Autor:Puig L
[Ad] Endereço:Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí 89, 08041, Barcelona, Catalonia, Spain.
[Ti] Título:Choice of first-line biologic therapy in psoriasis: understanding the past and shaping the future?
[So] Source:Br J Dermatol;177(3):623-624, 2017 09.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Fatores Biológicos
Psoríase
[Mh] Termos MeSH secundário: Terapia Biológica
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Biological Factors)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170924
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15791


  5 / 5281 MEDLINE  
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[PMID]:28899749
[Au] Autor:Hammoud SH; Omar AG; Eid AA; El-Mas MM
[Ad] Endereço:Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Beirut Arab University, Lebanon.
[Ti] Título:CYP4A/CYP2C modulation of the interaction of calcium channel blockers with cyclosporine on EDHF-mediated renal vasodilations in rats.
[So] Source:Toxicol Appl Pharmacol;334:110-119, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the immunosuppressant drug cyclosporine (CSA) upregulates EDHF-dependent renal vasodilations through altering CYP4A/CYP2C signaling, and (ii) calcium channel blockers modulate the CSA/EDHF/CYP interaction. Rats were treated with CSA, verapamil, nifedipine, or their combinations for 7days. Blood pressure (BP) was measured by tail-cuff plethysmography. Kidneys were then isolated, perfused with physiological solution containing L-NAME (NOS inhibitor) and diclofenac (cyclooxygenase inhibitor, DIC), and preconstricted with phenylephrine. CSA (25mgkg day for 7days) increased BP and augmented carbachol renal vasodilations. The co-treatment with verapamil (2mgkg day ) or nifedipine (3mgkg day ) abolished CSA hypertension and conversely affected carbachol vasodilations (increases vs. decreases). Infusion of MSPPOH (epoxyeicosatrienoic acids, EETs, inhibitor) reduced carbachol vasodilations in kidneys of all rat groups, suggesting the importance of EETs in these responses. By contrast, 20-Hydroxyeicosatetraenoic Acid (20-HETE) inhibition by HET0016 increased carbachol vasodilations in control rats, an effect that disappeared by CSA treatment, and reappeared in rats treated with CSA/verapamil or CSA/nifedipine. Renal protein expression of CYP2C and CYP4A as well as their vasoactive products (EETs/20-HETE) were increased in CSA-treated rats. Whereas the CYP2C/EETs effects of CSA were abolished by verapamil and intensified by nifedipine, the CYP4A/20-HETE effects were reduced by either CCB. Overall, nifedipine and verapamil blunts CSA hypertension but variably affected concomitantly enhanced EDHF-dependent renal vasodilations and alterations in CYP2C/CYP4A signaling.
[Mh] Termos MeSH primário: Fatores Biológicos/metabolismo
Bloqueadores dos Canais de Cálcio/farmacologia
Ciclosporina/farmacologia
Citocromo P-450 CYP4A/metabolismo
Sistema Enzimático do Citocromo P-450/metabolismo
Imunossupressores/farmacologia
[Mh] Termos MeSH secundário: Animais
Bloqueadores dos Canais de Cálcio/administração & dosagem
Ciclosporina/administração & dosagem
Citocromo P-450 CYP4A/genética
Sistema Enzimático do Citocromo P-450/genética
Interações Medicamentosas
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Imunossupressores/administração & dosagem
Rim/irrigação sanguínea
Masculino
Nifedipino/administração & dosagem
Nifedipino/farmacologia
Ratos
Ratos Sprague-Dawley
Vasodilatação/efeitos dos fármacos
Verapamil/administração & dosagem
Verapamil/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Factors); 0 (Calcium Channel Blockers); 0 (Immunosuppressive Agents); 0 (cytochrome P-450 CYP2C subfamily); 0 (endothelium-dependent hyperpolarization factor); 83HN0GTJ6D (Cyclosporine); 9035-51-2 (Cytochrome P-450 Enzyme System); CJ0O37KU29 (Verapamil); EC 1.14.15.3 (Cytochrome P-450 CYP4A); I9ZF7L6G2L (Nifedipine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE


  6 / 5281 MEDLINE  
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[PMID]:28882181
[Au] Autor:Di Nunzio M; Valli V; Tomás-Cobos L; Tomás-Chisbert T; Murgui-Bosch L; Danesi F; Bordoni A
[Ad] Endereço:Interdepartmental Centre for Industrial Agri-Food Research, University of Bologna, Piazza Goidanich 60, 47521, Cesena, Italy.
[Ti] Título:Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives?
[So] Source:BMC Complement Altern Med;17(1):453, 2017 Sep 07.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is often used to select the most promising molecules to be studied in vivo. To avoid misleading results, concentration and chemical form, exposure time, and potential cytotoxicity of the tested bioactives should be carefully set prior to any other experiments. METHODS: In this study the possible cytotoxicity of different bioactives (docosahexaenoic acid, propionate, cyanidin-3-O-glucoside, protocatechuic acid), was investigated in HepG2 cells using different methods. Bioactives were supplemented to cells at different concentrations within the physiological range in human blood, alone or in combination, considering two different exposure times. RESULTS: Reported data clearly evidence that in vitro cytotoxicity is tightly related to the exposure time, and it varies among bioactives, which could exert a cytotoxic effect even at a concentration within the in vivo physiological blood concentration range. Furthermore, co-supplementation of different bioactives can increase the cytotoxic effect. CONCLUSIONS: Our results underline the importance of in vitro cytotoxicity screening that should be considered mandatory before performing studies aimed to evaluate the effect of bioactives on other cellular parameters. Although this study is far from the demonstration of a toxic effect of the tested bioactives when administered to humans, it represents a starting point for future research aimed at verifying the existence of a potential hazard due to the wide use of high doses of multiple bioactives.
[Mh] Termos MeSH primário: Fatores Biológicos/toxicidade
Pesquisa Biomédica/métodos
Pesquisa Biomédica/normas
Sobrevivência Celular/efeitos dos fármacos
Modelos Biológicos
[Mh] Termos MeSH secundário: Antocianinas/toxicidade
Ácidos Docosa-Hexaenoicos/toxicidade
Glucosídeos/toxicidade
Células Hep G2
Seres Humanos
Hidroxibenzoatos/toxicidade
Propionatos/toxicidade
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Biological Factors); 0 (Glucosides); 0 (Hydroxybenzoates); 0 (Propionates); 25167-62-8 (Docosahexaenoic Acids); 36R5QJ8L4B (protocatechuic acid); 7084-24-4 (cyanidin 3-O-glucoside)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1962-2


  7 / 5281 MEDLINE  
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[PMID]:28817716
[Au] Autor:Yin D; Wang Q; Zhou X; Li Y
[Ad] Endereço:Department of Nephrology, the Second Xiangya Hospital, Central South University, Key Laboratory of Kidney Disease and Blood Purification in Hunan, Changsha, China.
[Ti] Título:Endothelial dysfunction in renal arcuate arteries of obese Zucker rats: The roles of nitric oxide, endothelium-derived hyperpolarizing factors, and calcium-activated K+ channels.
[So] Source:PLoS One;12(8):e0183124, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The roles of nitric oxide (NO), endothelium-derived hyperpolarizing factors (EDHF), and calcium-activated K+ (KCa) channels in diabetes-associated endothelial dysfunction of small renal arteries are not clear. The present study investigated acetylcholine (ACh)-induced vasorelaxation of renal arcuate arteries from obese Zucker (OZ) rats at different diabetes durations, and the relative contribution of NO, EDHF, and KCa channels to the endothelial dysfunction. OZ rats of 7 weeks (prediabetic stage), 12 weeks (early diabetic stage), and 20 weeks (late diabetic stage), and time-matched lean control rats, were studied. Segments of arcuate arteries (130 to 180 µm) were isolated, cannulated and pressurized. Vascular endothelial functions were tested using ACh-induced vasodilation. Our experiments demonstrated: (1) ACh-elicited vasodilation was impaired in OZ rats of 20 weeks, but not in rats of 7 and 12 weeks; (2) inhibition of NO or EDHF (contributed by epoxyeicosatrienoic acids [EETs]) production significantly decreased ACh-induced vasodilation in both lean and OZ rats of 20 weeks. The reduction of ACh-induced vasodilation by inhibition of NO or EDHF formation was less in OZ rats, as compared to lean rats; and (3) inhibition of KCa channels markedly reduced ACh-induced vasodilation in lean control rats, but not in OZ rats of 20 weeks. Our observations indicated that endothelium-dependent vasodilation in renal arcuate arteries is impaired in diabetes mellitus; NO and EDHF, mainly EETs, dominate the ACh-induced vasodilation in renal arcuate arteries; the contribution of NO and EETs is impaired in diabetic rats; KCa channels are involved in ACh-induced vasodilation; and the activity of KCa channels is downregulated in diabetes mellitus.
[Mh] Termos MeSH primário: Artérias/fisiopatologia
Fatores Biológicos/fisiologia
Endotélio Vascular/fisiopatologia
Rim/irrigação sanguínea
Óxido Nítrico/fisiologia
Obesidade/fisiopatologia
Canais de Potássio Cálcio-Ativados/fisiologia
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Masculino
Ratos
Ratos Zucker
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Factors); 0 (Potassium Channels, Calcium-Activated); 0 (endothelium-dependent hyperpolarization factor); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183124


  8 / 5281 MEDLINE  
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Andrade, Luís Eduardo Coelho
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[PMID]:28772079
[Au] Autor:Prado MS; Bendtzen K; Andrade LEC
[Ad] Endereço:a Rheumatology Division, Escola Paulista de Medicina , Universidade Federal de São Paulo , Sao Paulo , Brazil.
[Ti] Título:Biological anti-TNF drugs: immunogenicity underlying treatment failure and adverse events.
[So] Source:Expert Opin Drug Metab Toxicol;13(9):985-995, 2017 Sep.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Genetically engineered monoclonal antibodies and fusion proteins directed against cytokines or their receptors represent a breakthrough in the treatment of various chronic immune-inflammatory diseases. Areas covered: Studies show high remission rates in several diseases, but clinical practice shows a significant percentage of individuals who do not exhibit the desired response. Loss of therapeutic benefit after initial successful response is designated secondary failure. Immune-biological agents are not self-antigens and are therefore potentially immunogenic. Secondary failure is frequently caused by antibodies against immune-biologicals, known as anti-drug antibodies (ADA). ADA that neutralize circulating immune-biologicals and/or promote their clearance can reduce treatment efficacy. Furthermore, ADA can induce adverse events by diverse immunological mechanisms. This review provides a comprehensive overview of ADA in rheumatoid arthritis patients treated with anti-TNF immune-biologicals, and explores the concept of therapeutic drug monitoring (TDM) as an effective strategy to improve therapeutic management. Expert opinion: Monitoring circulating ADA and therapeutic immune-biological drugs is helpful when evaluating patients with secondary failure. However, immunological tests for ADA vary considerably regarding their ability to detect different types of ADA. Several assays are not designed to determine ADA-induced drug neutralizing capacity, and they may report clinically non-relevant data, especially if drug is present in test samples.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Artrite Reumatoide/tratamento farmacológico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Anticorpos/imunologia
Anticorpos Monoclonais/imunologia
Anticorpos Monoclonais/farmacologia
Anticorpos Monoclonais/uso terapêutico
Antirreumáticos/imunologia
Antirreumáticos/farmacologia
Artrite Reumatoide/imunologia
Fatores Biológicos/imunologia
Fatores Biológicos/farmacologia
Fatores Biológicos/uso terapêutico
Monitoramento de Medicamentos/métodos
Seres Humanos
Inflamação/tratamento farmacológico
Inflamação/imunologia
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies); 0 (Antibodies, Monoclonal); 0 (Antirheumatic Agents); 0 (Biological Factors); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2017.1360280


  9 / 5281 MEDLINE  
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[PMID]:28683133
[Au] Autor:Bautista-Caro MB; de Miguel E; Peiteado D; Plasencia-Rodríguez C; Villalba A; Monjo-Henry I; Puig-Kröger A; Sánchez-Mateos P; Martín-Mola E; Miranda-Carús ME
[Ad] Endereço:Department of Rheumatology, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain.
[Ti] Título:Increased frequency of circulating CD19+CD24hiCD38hi B cells with regulatory capacity in patients with Ankylosing spondylitis (AS) naïve for biological agents.
[So] Source:PLoS One;12(7):e0180726, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our objective was to study the frequency of circulating CD19+CD24hiCD38hi B cells (Breg) in AS patients. To this end, peripheral blood was drawn from AS patients naïve for TNF blockers (AS/nb) (n = 42) and healthy controls (HC) (n = 42). Six patients donated blood for a second time, 6 months after initiating treatment with anti-TNFα drugs. After isolation by Ficoll-Hypaque, PBMCs were stained with antibodies to CD3, CD4, CD19, CD24, and CD38, and examined by cytometry. For functional studies, total CD19+ B cells were isolated from PBMCs of 3 HC by magnetical sorting. Breg-depleted CD19+ B cells were obtained after CD19+CD24hiCD38hi B cells were removed from total CD19+ cells by cytometry. Total CD19+ B cells or Breg-depleted CD19+ B cells were established in culture and stimulated through their BCR. Secretion of IFNγ was determined by ELISA in culture supernatants. When compared with HC, AS/nb patients demonstrated a significantly increased frequency of Breg cells, which was independent of disease activity. Anti-TNFα drugs induced a significant reduction of circulating Breg numbers, which were no longer elevated after six months of treatment. Functional in vitro studies showed that the secretion of IFNγ was significantly higher in Breg-depleted as compared with total CD19+ B cells, indicating that Breg can downmodulate B cell pro-inflammatory cytokine secretion. In summary, an increased frequency of circulating CD19+CD24hiCD38hi B cells is observed in AS/nb patients, that is not related with disease activity; anti-TNFα drugs are able to downmodulate circulating Breg numbers in AS.
[Mh] Termos MeSH primário: ADP-Ribosil Ciclase 1/imunologia
Antígenos CD19/imunologia
Linfócitos B/imunologia
Fatores Biológicos/uso terapêutico
Antígeno CD24/imunologia
Espondilite Anquilosante/imunologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Espondilite Anquilosante/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD19); 0 (Biological Factors); 0 (CD24 Antigen); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180726


  10 / 5281 MEDLINE  
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[PMID]:28665427
[Au] Autor:Mária J; Ingrid Z
[Ad] Endereço:Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Medical Faculty, Comenius University, 813 72 Bratislava, Slovakia. ingrid.zitnanova@fmed.uniba.sk.
[Ti] Título:Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro.
[So] Source:Food Funct;8(7):2394-2418, 2017 Jul 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Senescence is a permanent cell cycle arrest that is accompanied by changes in cell morphology and physiology occurring in vitro and in vivo. Senescence evolved as a beneficial response to damage promoting wound healing, limiting fibrosis, fighting against cancer and helping embryonic development. However, excessive accumulation of senescent cells is considered to play a substantial role in the development of aging-related diseases and other morphological and physiological changes associated with aging. Therefore, the aim of many researchers is to find out a way to eliminate senescent cells and improve the health condition of aging people. Bioactive compounds e.g. polyphenols, vitamins, phenols, carotenoids, ginsenosides, omega-3 fatty acids, and compounds isolated from algae (phloroglucinol, sargachromal) are known to affect important biological functions. Recent in vitro studies have revealed that they can protect different types of cells against stress induced senescence (SISP), delay replicative senescence, rejuvenate senescent cells and exert senolytic effects. This review summarizes how the biological compounds listed above affect cell morphology, cell proliferation, specific cell functions, the activity of senescence-associated ß-galactosidase (SA-ß-gal), the shortening of telomeres and reduction of telomerase activity, production of intracellular reactive oxygen species (ROS) and lipid peroxidation products, expression of antioxidant enzymes, expression of p53 and p21 - key effectors of cell cycle arrest leading to senescence - and expression of some key components of senescence associated secretory phenotype (SASP) in replicative senescence, stress induced senescence (SISP) and under conditions which may lead to the development of senescence such as UV-A and UV-B irradiation of cells and the production of matrix metalloproteinases (a component of the SASP) in cells. Finally, future perspectives of this research are discussed.
[Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos
Fatores Biológicos/farmacologia
Senescência Celular/efeitos dos fármacos
[Mh] Termos MeSH secundário: Envelhecimento/metabolismo
Animais
Proliferação Celular
Seres Humanos
Transdução de Sinais
Telômero/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Factors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00161d



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde