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  1 / 2510 MEDLINE  
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[PMID]:28463230
[Au] Autor:Bagchi S; He Y; Zhang H; Cao L; Van Rhijn I; Moody DB; Gudjonsson JE; Wang CR
[Ad] Endereço:Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
[Ti] Título:CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice.
[So] Source:J Clin Invest;127(6):2339-2352, 2017 Jun 01.
[Is] ISSN:1558-8238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A large proportion of human T cells are autoreactive to group 1 CD1 proteins, which include CD1a, CD1b, and CD1c. However, the physiological role of the CD1 proteins remains poorly defined. Here, we have generated a double-transgenic mouse model that expresses human CD1b and CD1c molecules (hCD1Tg) as well as a CD1b-autoreactive TCR (HJ1Tg) in the ApoE-deficient background (hCD1Tg HJ1Tg Apoe-/- mice) to determine the role of CD1-autoreactive T cells in hyperlipidemia-associated inflammatory diseases. We found that hCD1Tg HJ1Tg Apoe-/- mice spontaneously developed psoriasiform skin inflammation characterized by T cell and neutrophil infiltration and a Th17-biased cytokine response. Anti-IL-17A treatment ameliorated skin inflammation in vivo. Additionally, phospholipids and cholesterol preferentially accumulated in diseased skin and these autoantigens directly activated CD1b-autoreactive HJ1 T cells. Furthermore, hyperlipidemic serum enhanced IL-6 secretion by CD1b+ DCs and increased IL-17A production by HJ1 T cells. In psoriatic patients, the frequency of CD1b-autoreactive T cells was increased compared with that in healthy controls. Thus, this study has demonstrated the pathogenic role of CD1b-autoreactive T cells under hyperlipidemic conditions in a mouse model of spontaneous skin inflammation. As a large proportion of psoriatic patients are dyslipidemic, this finding is of clinical significance and indicates that self-lipid-reactive T cells might serve as a possible link between hyperlipidemia and psoriasis.
[Mh] Termos MeSH primário: Antígenos CD1/metabolismo
Dermatite/imunologia
Hiperlipidemias/imunologia
Psoríase/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Técnicas de Cocultura
Seres Humanos
Hiperlipidemias/complicações
Ativação Linfocitária
Camundongos Knockout
Infiltração de Neutrófilos
Pele/imunologia
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD1); 0 (CD1b antigen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  2 / 2510 MEDLINE  
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[PMID]:28847997
[Au] Autor:Carrera Silva EA; Nowak W; Tessone L; Olexen CM; Ortiz Wilczyñski JM; Estecho IG; Elena G; Errasti AE; Rosso DA
[Ad] Endereço:Instituto de Medicina Experimental, Academia Nacional de Medicina, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
[Ti] Título:CD207 CD1a cells circulate in pediatric patients with active Langerhans cell histiocytosis.
[So] Source:Blood;130(17):1898-1902, 2017 Oct 26.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Langerhans cell histiocytosis (LCH) is a rare disease with an unknown etiology characterized by heterogeneous lesions containing CD207 CD1a cells that can arise in almost any tissue and cause significant morbidity and mortality. Precursors of pathological Langerhans cells have yet to be defined. Our aim was to identify circulating CD207 CD1a cells and their inducers in LCH. Expression of CD207 and CD1a in the blood myeloid compartment as well as thymic stromal lymphopoietin (TSLP) and transforming growth factor ß (TGF-ß) plasma levels were measured in 22 pediatric patients with active disease (AD) or nonactive disease (NAD). In patients with AD vs those with NAD, the myeloid compartment showed an increased CD11b (CD11b plus CD11b ) fraction (39.7 ± 3.6 vs 18.6 ± 1.9), a higher percentage of circulating CD11b CD11c CD207 cells (44.5 ± 11.3 vs 3.2 ± 0.5), and the presence of CD11c CD207 CD1a cells (25.0 ± 9.1 vs 2.3 ± 0.5). Blood CD207 CD1a cells were not observed in adult controls or umbilical cord. Increased TSLP and TGF-ß levels were detected in patients with AD. Interestingly, plasma from patients with AD induces CD207 expression on CD14 monocytes. We conclude that CD207 CD1a cells are circulating in patients with active LCH, and TSLP and TGF-ß are potential drivers of Langerhans-like cells in vivo.
[Mh] Termos MeSH primário: Antígenos CD1/metabolismo
Antígenos CD/metabolismo
Histiocitose de Células de Langerhans/metabolismo
Histiocitose de Células de Langerhans/patologia
Lectinas Tipo C/metabolismo
Lectinas de Ligação a Manose/metabolismo
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Citocinas/sangue
Feminino
Histiocitose de Células de Langerhans/sangue
Seres Humanos
Lactente
Masculino
Fator de Crescimento Transformador beta/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Antigens, CD1); 0 (CD1a antigen); 0 (CD207 protein, human); 0 (Cytokines); 0 (Lectins, C-Type); 0 (Mannose-Binding Lectins); 0 (Transforming Growth Factor beta); 0 (thymic stromal lymphopoietin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2017-05-782730


  3 / 2510 MEDLINE  
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[PMID]:28720687
[Au] Autor:van Leeuwen-Kerkhoff N; Lundberg K; Westers TM; Kordasti S; Bontkes HJ; de Gruijl TD; Lindstedt M; van de Loosdrecht AA
[Ad] Endereço:Department of Hematology, Cancer Center Amsterdam, Vrije Universiteit Amsterdam University Medical Center, Amsterdam, The Netherlands.
[Ti] Título:Transcriptional profiling reveals functional dichotomy between human slan non-classical monocytes and myeloid dendritic cells.
[So] Source:J Leukoc Biol;102(4):1055-1068, 2017 Oct.
[Is] ISSN:1938-3673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human 6-sulfo LacNac-positive (slan ) cells have been subject to a paradigm debate. They have previously been classified as a distinct dendritic cell (DC) subset. However, evidence has emerged that they may be more related to monocytes than to DCs. To gain deeper insight into the functional specialization of slan cells, we have compared them with both conventional myeloid DC subsets (CD1c and CD141 ) in human peripheral blood (PB). With the use of genome-wide transcriptional profiling, as well as functional tests, we clearly show that slan cells form a distinct, non-DC-like population. They cluster away from both DC subsets, and their gene-expression profile evidently suggests involvement in distinct inflammatory processes. An extensive transcriptional meta-analysis confirmed the relationship of slan cells with the monocytic compartment rather than with DCs. From a functional perspective, their ability to prime CD4 and CD8 T cells is relatively low. Combined with the finding that "antigen presentation by MHC class II" is at the top of under-represented pathways in slan cells, this points to a minimal role in directing adaptive T cell immunity. Rather, the higher expression levels of complement receptors on their cell surface, together with their high secretion of IL-1ß and IL-6, imply a specific role in innate inflammatory processes, which is consistent with their recent identification as non-classical monocytes. This study extends our knowledge on DC/monocyte subset biology under steady-state conditions and contributes to our understanding of their role in immune-mediated diseases and their potential use in immunotherapeutic strategies.
[Mh] Termos MeSH primário: Células Dendríticas/imunologia
Monócitos/imunologia
Transcrição Genética/imunologia
Proteínas Supressoras de Tumor
[Mh] Termos MeSH secundário: Antígenos CD1/imunologia
Antígenos de Superfície/imunologia
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Células Dendríticas/citologia
Perfilação da Expressão Gênica
Glicoproteínas/imunologia
Seres Humanos
Interleucina-1beta/imunologia
Interleucina-6/imunologia
Monócitos/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD1); 0 (Antigens, Surface); 0 (CD1C protein, human); 0 (Glycoproteins); 0 (IL1B protein, human); 0 (IL6 protein, human); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (SLAN protein, human); 0 (Tumor Suppressor Proteins); 0 (blood dendritic cell antigen 3, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.1189/jlb.3MA0117-037R


  4 / 2510 MEDLINE  
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[PMID]:28707750
[Au] Autor:Cameron SA; White SM; Arrollo D; Shulman ST; Rowley AH
[Ad] Endereço:Department of Pediatrics/Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[Ti] Título:Arterial immune protein expression demonstrates the complexity of immune responses in Kawasaki disease arteritis.
[So] Source:Clin Exp Immunol;190(2):244-250, 2017 Nov.
[Is] ISSN:1365-2249
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A more complete understanding of immune-mediated damage to the coronary arteries in children with Kawasaki disease (KD) is required for improvements in patient treatment and outcomes. We recently reported the transcriptional profile of KD coronary arteritis, and in this study sought to determine protein expression of transcriptionally up-regulated immune genes in KD coronary arteries from the first 2 months after disease onset. We examined the coronary arteries of 12 fatal KD cases and 13 childhood controls for expression of a set of proteins whose genes were highly up-regulated in the KD coronary artery transcriptome: allograft inflammatory factor 1 (AIF1), interleukin 18 (IL-18), CD74, CD1c, CD20 (MS4A1), Toll-like receptor 7 (TLR-7) and Z-DNA binding protein 1 (ZBP1). Immunohistochemistry and immunofluorescence studies were performed to evaluate protein expression and co-localization, respectively. AIF1 was expressed transmurally in KD arteritis and localized to macrophages and myeloid dendritic cells. CD74, which interacts with major histocompatibility complex (MHC) class II on antigen-presenting cells, localized to the intima-media. CD1c, a marker of myeloid dendritic cells, was expressed in a transmural pattern, as were IL-18 and CD20. ZBP1 and TLR-7 were up-regulated compared to controls, but less highly compared to the other proteins. These findings provide evidence of antigen presentation and interferon response in KD arteritis. In combination with prior studies demonstrating T lymphocyte activation, these results demonstrate the complexity of the KD arterial immune response.
[Mh] Termos MeSH primário: Arterite/imunologia
Vasos Coronários/imunologia
Expressão Gênica
Síndrome de Linfonodos Mucocutâneos/imunologia
Síndrome de Linfonodos Mucocutâneos/metabolismo
[Mh] Termos MeSH secundário: Apresentação do Antígeno
Antígenos CD/genética
Antígenos CD1/genética
Antígenos CD20/genética
Arterite/fisiopatologia
Aneurisma Coronário/imunologia
Vasos Coronários/fisiopatologia
Proteínas de Ligação a DNA/genética
Feminino
Imunofluorescência
Perfilação da Expressão Gênica
Glicoproteínas/genética
Seres Humanos
Imuno-Histoquímica
Lactente
Interleucina-18/genética
Masculino
Síndrome de Linfonodos Mucocutâneos/complicações
Síndrome de Linfonodos Mucocutâneos/mortalidade
Sialiltransferases/genética
Receptor 7 Toll-Like/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AIF1 protein, human); 0 (Antigens, CD); 0 (Antigens, CD1); 0 (Antigens, CD20); 0 (CD1C protein, human); 0 (DNA-Binding Proteins); 0 (Glycoproteins); 0 (Interleukin-18); 0 (TLR7 protein, human); 0 (Toll-Like Receptor 7); 0 (ZBP1 protein, human); EC 2.4.99.- (Sialyltransferases); EC 2.4.99.1 (ST6GAL1 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1111/cei.13010


  5 / 2510 MEDLINE  
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[PMID]:28704477
[Au] Autor:Kosten IJ; van de Ven R; Thon M; Gibbs S; de Gruijl TD
[Ad] Endereço:Department of Dermatology, VU University Medical Center, Amsterdam, the Netherlands.
[Ti] Título:Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin.
[So] Source:PLoS One;12(7):e0180333, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antigen exposure to oral mucosa is generally thought to lead to immune tolerance induction. However, very little is known about the subset composition and function of dendritic cells (DC) migrating from human oral mucosa. Here we show that migratory DC from healthy human gingival explants consist of the same phenotypic subsets in the same frequency distribution as DC migrating from human skin. The gingival CD1a+ Langerhans cell and interstitial DC subsets lacked CXCR4 expression in contrast to their cutaneous counterparts, pointing to different migration mechanisms, consistent with previous observations in constructed skin and gingival equivalents. Remarkably, without any exogenous conditioning, gingival explants released higher levels of inflammatory cytokines than human skin explants, resulting in higher DC migration rates and a superior ability of migrated DC to prime allogeneic T cells and to induce type-1 effector T cell differentiation. From these observations we conclude that rather than an intrinsic ability to induce T cell tolerance, DC migrating from oral mucosa may have a propensity to induce effector T cell immunity and maintain a high state of alert against possible pathogenic intruders in the steady state. These findings may have implications for oral immunization strategies.
[Mh] Termos MeSH primário: Células Dendríticas/citologia
Mucosa Bucal/citologia
Receptores CXCR4/metabolismo
Pele/citologia
[Mh] Termos MeSH secundário: Antígenos CD1/metabolismo
Diferenciação Celular
Movimento Celular
Citocinas/metabolismo
Células Dendríticas/imunologia
Seres Humanos
Células de Langerhans/citologia
Células de Langerhans/imunologia
Mucosa Bucal/metabolismo
Fenótipo
Pele/metabolismo
Linfócitos T/imunologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD1); 0 (CD1a antigen); 0 (CXCR4 protein, human); 0 (Cytokines); 0 (Receptors, CXCR4)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180333


  6 / 2510 MEDLINE  
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[PMID]:28691226
[Au] Autor:Casorati G; Dellabona P
[Ad] Endereço:Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
[Ti] Título:Of self-lipids, CD1-restricted T cells, and contact sensitization.
[So] Source:Eur J Immunol;47(7):1119-1122, 2017 Jul.
[Is] ISSN:1521-4141
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Contact hypersensitivity (CHS) in rodents and contact dermatitis in humans are long-known pathological conditions caused by MHC-restricted T-cell responses. These responses are triggered upon T-cell recognition of neo-antigenic determinants, which are generated by a variety of environmental contact sensitizer (CS) chemicals associating with self-proteins to comprise these neo-antigens. In this issue of the European Journal of Immunology, Betts et al. [Eur. J. Immunol. 2017. 47: 1171-1180] provide intriguing data implying that common small molecule CSs such as dinitrochlorobenzene can also recruit and activate autoreactive CD1-restricted T cells specific for cell-endogenous lipids, which are enriched in human skin. The effects of dinitrochlorobenzene on CD1 T-cell recruitment and function were dependent on newly synthesized CD1 molecules and the presence of endogenous lipids. These findings shed new light on unanticipated mechanisms that have potential clinical relevance on a common and highly distressing disease state.
[Mh] Termos MeSH primário: Antígenos CD1/imunologia
Dermatite de Contato/imunologia
Lipídeos/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Apresentação do Antígeno
Seres Humanos
Camundongos
Células T Matadoras Naturais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD1); 0 (Lipids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1002/eji.201747112


  7 / 2510 MEDLINE  
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[PMID]:28665555
[Au] Autor:Van Rhijn I; Iwany SK; Fodran P; Cheng TY; Gapin L; Minnaard AJ; Moody DB
[Ad] Endereço:Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[Ti] Título:CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.
[So] Source:Eur J Immunol;47(9):1525-1534, 2017 Sep.
[Is] ISSN:1521-4141
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Mycobacterium tuberculosis synthesizes a thick cell wall comprised of mycolic acids (MA), which are foreign antigens for human T cells. T-cell clones from multiple donors were used to determine the fine specificity of MA recognition by human αß T cells. Most CD1-presented lipid antigens contain large hydrophilic head groups comprised of carbohydrates or peptides that dominate patterns of T-cell specificity. MA diverges from the consensus antigen motif in that it lacks a head group. Using multiple forms of natural and synthetic MA and MA-specific T-cells with different T-cell receptors, we found that, unlike antigens with larger head groups, lipid length strongly controlled T-cell responses to MA. In addition, the three forms of MA that naturally occur in M. tuberculosis that differ in modifications on the lipid tail, differ in their potency for activating MA-specific T-cell clones. Thus, naturally occurring MA forms should be considered as separate, partly cross-reactive antigens. Two of the three forms of MA could be loaded onto human CD1b proteins, creating working CD1b-MA tetramers. The creation of CD1b-MA tetramers represents a new tool for future studies that track the effector functions and kinetics of MA-specific T-cells ex vivo.
[Mh] Termos MeSH primário: Antígenos de Bactérias/metabolismo
Antígenos CD1/metabolismo
Parede Celular/metabolismo
Mycobacterium tuberculosis/imunologia
Ácidos Micólicos/metabolismo
Especificidade do Receptor de Antígeno de Linfócitos T
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Antígenos de Bactérias/imunologia
Células Clonais
Reações Cruzadas
Seres Humanos
Técnicas Imunológicas
Lipídeos/química
Ativação Linfocitária
Ácidos Micólicos/química
Ácidos Micólicos/imunologia
Ligação Proteica
Receptores de Antígenos de Linfócitos T alfa-beta/genética
Receptores de Antígenos de Linfócitos T alfa-beta/metabolismo
Linfócitos T/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Antigens, CD1); 0 (CD1b antigen); 0 (Lipids); 0 (Mycolic Acids); 0 (Receptors, Antigen, T-Cell, alpha-beta)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1002/eji.201747062


  8 / 2510 MEDLINE  
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[PMID]:28521873
[Au] Autor:Anastasilakis AD; Polyzos SA; Tsoli M; Papatheodorou A; Kokkoris P; Kaltsas G; Terpos E; Makras P
[Ad] Endereço:Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece.
[Ti] Título:Low periostin levels in adult patients with Langerhans cell histiocytosis are independently associated with the disease activity.
[So] Source:Metabolism;71:198-201, 2017 Jun.
[Is] ISSN:1532-8600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Langerhans cell histiocytosis (LCH) is a rare proliferative disease of cells of the CD1a+/CD207+ myeloid dendritic cell lineage that may infiltrate one or more organs or systems at all ages. We aimed to evaluate periostin and sclerostin serum levels in adult patients with LCH. PROCEDURES: This was a cross-sectional study comparing 38 adult patients with LCH with 38 age- and sex-matched healthy controls. Serum periostin and sclerostin levels were measured to compare between LCH patients and controls as well as between patients with active and non-active disease. RESULTS: Serum periostin levels were significantly lower in LCH patients than controls (457±72ng/ml vs. 721±79ng/ml, p=0.014) but this was not the case for sclerostin levels which did not differ between patients and controls, respectively (29.0±1.8pmol/L vs. 39.5±3.8pmol/L, p=0.12). Patients with active disease had significantly lower periostin levels than those with inactive disease (240±78ng/ml vs. 558±94ng/ml, p=0.008). No effect of specific site involvement, extend of disease, or treatment administered was found on any of the above parameters measured. CONCLUSIONS: Lower serum periostin levels were observed in adult LCH patients with active disease. The finding warrants further investigation to define whether periostin could serve as a serum biomarker for LCH activity.
[Mh] Termos MeSH primário: Moléculas de Adesão Celular/sangue
Moléculas de Adesão Celular/deficiência
Histiocitose de Células de Langerhans/sangue
Histiocitose de Células de Langerhans/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Antígenos CD1
Biomarcadores/sangue
Índice de Massa Corporal
Proteínas Morfogenéticas Ósseas/sangue
Estudos Transversais
Feminino
Marcadores Genéticos
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD1); 0 (Biomarkers); 0 (Bone Morphogenetic Proteins); 0 (CD1a antigen); 0 (Cell Adhesion Molecules); 0 (Genetic Markers); 0 (POSTN protein, human); 0 (SOST protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


  9 / 2510 MEDLINE  
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[PMID]:28512190
[Au] Autor:Milne P; Bigley V; Bacon CM; Néel A; McGovern N; Bomken S; Haniffa M; Diamond EL; Durham BH; Visser J; Hunt D; Gunawardena H; Macheta M; McClain KL; Allen C; Abdel-Wahab O; Collin M
[Ad] Endereço:Institute of Cellular Medicine and.
[Ti] Título:Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults.
[So] Source:Blood;130(2):167-175, 2017 Jul 13.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are rare histiocytic disorders induced by somatic mutation of MAPK pathway genes. mutation is the most common mutation in both conditions and also occurs in the hematopoietic neoplasm hairy cell leukemia (HCL). It is not known if adult LCH or ECD arises from hematopoietic stem cells (HSCs), nor which potential blood borne precursors lead to the formation of histiocytic lesions. In this study, allele-specific polymerase chain reaction was used to map the neoplastic clone in 20 adults with LCH, ECD, and HCL. was tracked to classical monocytes, nonclassical monocytes, and CD1c myeloid dendritic cells (DCs) in the blood, and mutations were observed in HSCs and myeloid progenitors in the bone marrow of 4 patients. The pattern of involvement of peripheral blood myeloid cells was indistinguishable between LCH and ECD, although the histiocytic disorders were distinct to HCL. As reported in children, detection of in peripheral blood of adults was a marker of active multisystem LCH. The healthy counterparts of myeloid cells affected by mutation had a range of differentiation potentials depending on exogenous signals. CD1c DCs acquired high langerin and CD1a with granulocyte-macrophage colony-stimulating factor and transforming growth factor ß alone, whereas CD14 classical monocytes required additional notch ligation. Both classical and nonclassical monocytes, but not CD1c DCs, made foamy macrophages easily in vitro with macrophage colony-stimulating factor and human serum. These studies are consistent with a hematopoietic origin and >1 immediate cellular precursor in both LCH and ECD.
[Mh] Termos MeSH primário: Células da Medula Óssea/patologia
Doença de Erdheim-Chester/diagnóstico
Células-Tronco Hematopoéticas/patologia
Histiocitose de Células de Langerhans/diagnóstico
Proteínas Proto-Oncogênicas B-raf/genética
[Mh] Termos MeSH secundário: Adulto
Alelos
Antígenos CD/genética
Antígenos CD/imunologia
Antígenos CD1/genética
Antígenos CD1/imunologia
Células da Medula Óssea/imunologia
Diferenciação Celular
Células Dendríticas/imunologia
Células Dendríticas/patologia
Diagnóstico Diferencial
Doença de Erdheim-Chester/genética
Doença de Erdheim-Chester/imunologia
Doença de Erdheim-Chester/patologia
Feminino
Células Espumosas/imunologia
Células Espumosas/patologia
Expressão Gênica
Glicoproteínas/genética
Glicoproteínas/imunologia
Fator Estimulador de Colônias de Granulócitos e Macrófagos/genética
Fator Estimulador de Colônias de Granulócitos e Macrófagos/imunologia
Células-Tronco Hematopoéticas/imunologia
Histiocitose de Células de Langerhans/genética
Histiocitose de Células de Langerhans/imunologia
Histiocitose de Células de Langerhans/patologia
Seres Humanos
Imunofenotipagem
Lectinas Tipo C/genética
Lectinas Tipo C/imunologia
Receptores de Lipopolissacarídeos/genética
Receptores de Lipopolissacarídeos/imunologia
Masculino
Lectinas de Ligação a Manose/genética
Lectinas de Ligação a Manose/imunologia
Monócitos/imunologia
Monócitos/patologia
Mutação
Proteínas Proto-Oncogênicas B-raf/imunologia
Receptores Notch/genética
Receptores Notch/imunologia
Fator de Crescimento Transformador beta/genética
Fator de Crescimento Transformador beta/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Antigens, CD1); 0 (CD1C protein, human); 0 (CD1a antigen); 0 (CD207 protein, human); 0 (Glycoproteins); 0 (Lectins, C-Type); 0 (Lipopolysaccharide Receptors); 0 (Mannose-Binding Lectins); 0 (Receptors, Notch); 0 (Transforming Growth Factor beta); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor); EC 2.7.11.1 (BRAF protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2016-12-757823


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[PMID]:28440548
[Au] Autor:Betts RJ; Perkovic A; Mahapatra S; Del Bufalo A; Camara K; Howell AR; Martinozzi Teissier S; De Libero G; Mori L
[Ad] Endereço:Singapore Immunology Network, Agency for Science, Technology and Research, Singapore.
[Ti] Título:Contact sensitizers trigger human CD1-autoreactive T-cell responses.
[So] Source:Eur J Immunol;47(7):1171-1180, 2017 Jul.
[Is] ISSN:1521-4141
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Allergic contact dermatitis is a primarily T-cell-mediated inflammatory skin disease induced by exposure to small molecular-weight haptens, which covalently bind to proteins. The abundance of cutaneous T cells that recognize CD1a antigen-presenting molecules raises the possibility that MHC-independent antigen presentation may be relevant in some hapten-driven immune responses. Here we examine the ability of contact sensitizers to influence CD1-restricted immunity. Exposure of human antigen-presenting cells such as monocyte-derived dendritic cells and THP-1 cells to the prototypical contact sensitizer dinitrochlorobenzene potentiated the response of CD1a- and CD1d-autoreactive T cells, which released a vast array of cytokines in a CD1- and TCR-dependent manner. The potentiating effects of dinitrochlorobenzene depended upon newly synthesized CD1 molecules and the presence of endogenous stimulatory lipids. Further examination of a broad panel of contact sensitizers revealed 1,4-benzoquinone, resorcinol, isoeugenol, and cinnamaldehyde to activate the same type of CD1-restricted responses. These findings provide a basis for the antigen-specific activation of skin-associated CD1-restricted T cells by small molecules and may have implications for contact sensitizer-induced inflammatory skin diseases.
[Mh] Termos MeSH primário: Antígenos CD1/imunologia
Dermatite de Contato/imunologia
Células T Matadoras Naturais/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Acroleína/análogos & derivados
Acroleína/farmacologia
Apresentação do Antígeno
Benzoquinonas/farmacologia
Linhagem Celular
Células Dendríticas/imunologia
Dinitroclorobenzeno/farmacologia
Eugenol/análogos & derivados
Eugenol/farmacologia
Seres Humanos
Lipídeos/imunologia
Ativação Linfocitária
Monócitos/efeitos dos fármacos
Resorcinóis/farmacologia
Pele/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD1); 0 (Benzoquinones); 0 (Lipids); 0 (Resorcinols); 3T8H1794QW (Eugenol); 5M0MWY797U (isoeugenol); 7864XYD3JJ (Acrolein); GE3IBT7BMN (Dinitrochlorobenzene); SR60A3XG0F (cinnamic aldehyde); YUL4LO94HK (resorcinol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1002/eji.201746939



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