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Pesquisa : D23.050.301.264.894.157 [Categoria DeCS]
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[PMID]:29267667
[Au] Autor:Silva LABD; Sá MAR; Melo RA; Pereira JDS; Silveira ÉJDD; Miguel MCDC
[Ad] Endereço:Universidade Federal do Rio Grande do Norte - UFRN, Postgraduate Program in Oral Pathology, Natal, RN, Brazil.
[Ti] Título:Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts.
[So] Source:Braz Oral Res;31:e106, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare the number of CD57+ natural killer (NK) cells and CD8+ T lymphocytes between periapical granulomas (PGs) and radicular cysts (RCs). Twenty-fives cases of PGs and 25 of RCs were submitted to histological analysis and immunohistochemistry using anti-CD57 and anti-CD8 biomarkers. Positive cells were counted in 10 fields (400× magnification) and the median value was calculated for each case. Statistical tests were used to evaluate differences in the number of CD57+ NK cells and CD8+ T lymphocytes according to type of lesion, intensity of the infiltrate and thickness of the lining epithelium. The number of CD57+ NK cells and CD8+ T lymphocytes was higher in PGs than in RCs (p = 0.129 and p = 0.541, respectively). Comparison of the number of CD57+ NK cells in atrophic and hyperplastic epithelium revealed a larger number of cells in the atrophic epithelium (p = 0.042). A larger number of CD57+ NK cells and CD8+ T lymphocytes were observed in grade III infiltrates compared to grade I/II (p = 0.145 and p = 0.725, respectively). CD8+ T lymphocytes were more prevalent than CD57+ NK cells in most cases when PGs and RCs were analyzed separately or in combination (p < 0.0001). CD57+ NK cells and CD8+ T lymphocytes play a key role in antiviral defense and the presence of these cells supports evidence suggesting the participation of these microorganisms in the pathogenesis of PGs and RCs. The response mediated by CD8+ T lymphocytes was more frequent, indicating greater participation of the adaptive immunity in these chronic lesions.
[Mh] Termos MeSH primário: Antígenos CD57/análise
Linfócitos T CD8-Positivos/patologia
Células Matadoras Naturais/patologia
Granuloma Periapical/patologia
Cisto Radicular/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Biomarcadores/análise
Contagem de Células
Epitélio
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Granuloma Periapical/imunologia
Cisto Radicular/imunologia
Valores de Referência
Índice de Gravidade de Doença
Estatísticas não Paramétricas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (CD57 Antigens)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29308859
[Au] Autor:Radovic Janosevic D; Popovic J; Krstic M; Tubic-Pavlovic A; Stefanovic M; Pop-Trajkovic S
[Ti] Título:The structure of immunocompetent decidual cells in recurrent missed abortions.
[So] Source:Vojnosanit Pregl;73(4):306-11, 2016 Apr.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Recurrent or habitual missed abortions (RMA) are defined as three or more consecutive abortions. In the first trimester of pregnancy habitual missed abortions occur in about 1% of population. The aim of this immunohistochemical study of decidua in RMA of unknown etiology was to identify subpopulations of decidual lymphocytes in recurrent miscarriages and compare the distribution of immunocompetent cells in artificial abortions and RMA. Methods. The study included 30 women with at least 2 consecutive miscarriages in the first trimester of pregnancy. Curettements of the third missed abortion were immunohistochemically analyzed. The control group consisted of 20 women without loaded reproductive anamnesis, with the abortion for social reasons. Criteria for exclusion from the study were diagnosed uterine anomalies, positive screening for thrombophilia and women who suffered from diabetes mellitus and disorders in the function of the thyroid gland. Immunophenotyping was performed by immuno-alkaline phosphatase (APAAP) using monoclonal antibodies: CD 30, CD 45 RO, CD 56 and CD 57, CD 68. Methods: The number of missed abortions (1,223) was on the average 9.7% of all deliveriies during the test period. Among them RMA were registered in 52 (4.2%) patients and in 30 (57%) the exact etiology of abortions was not determined. RMA was most common in the 25-34 years of age group. The largest number of RMA showed the ultrasound characteristics of missed abortion in 60% of cases and was in nulliparous patients (76.7%). The number of NK CD56 positive cells did not differ significantly between the types of abortion. In the decidual tissue, a number of NK CD57 positive cells was significantly higher in missed abortions compared to artificial interruptions (p < 0.01). In artificial termination of pregnancy there was an absolute predominance of CD45RO lymphocyte subpopulations, whereas in the RMA group there was slightly greater predominance of CD30 positive cells. The completed analysis showed a significantly higher number of CD68 positive macrophages in a decidual tissue of RMA pregnancy (p < 0.01). Results: The number and phenotypic structure of NK cells are significantly different in normal pregnancy decidua and in RMA. The NK cell dominance is present in the RMA group, in favor of CD56+ and CD 57 of subpopulations with increased CD30 of T lymphocyte subpopulations. Macrophages are more numerous in the decidua of pregnancies ended in abortion, so the cause to RMA of unknown etiology in a number of cases could be disregulation of immunocompetent cells.
[Mh] Termos MeSH primário: Aborto Retido/imunologia
Decídua/imunologia
Decídua/metabolismo
Células Matadoras Naturais/imunologia
[Mh] Termos MeSH secundário: Aborto Retido/metabolismo
Adulto
Antígeno CD56
Antígenos CD57
Feminino
Seres Humanos
Imuno-Histoquímica
Imunofenotipagem
Antígeno Ki-1
Células Matadoras Naturais/classificação
Células Matadoras Naturais/metabolismo
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD56 Antigen); 0 (CD57 Antigens); 0 (Ki-1 Antigen); 0 (NCAM1 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141226018R


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[PMID]:28456719
[Au] Autor:Jansen MAE; van den Heuvel D; Jaddoe VWV; van Zelm MC; Moll HA
[Ad] Endereço:The Generation R Study Group, Erasmus MC-Sophia, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands; Department of Immunology, Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands.
[Ti] Título:Abnormalities in CD57+ cytotoxic T cells and Vδ1+ γδT cells in subclinical celiac disease in childhood are affected by cytomegalovirus. The Generation R Study.
[So] Source:Clin Immunol;183:233-239, 2017 10.
[Is] ISSN:1521-7035
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Celiac disease (CD) is a digestive and autoimmune disorder driven by an immune response to modified gluten peptides. Affected intestines show infiltrates of various T-cell and NK-cell subsets. It is currently unclear if individuals with subclinical CD have systemic abnormalities in immune cells. We here studied whether subclinical CD is associated with changes in blood CD57-expressing and Vδ1-expressing lymphocytes in children, and whether cytomegalovirus (CMV) infection modifies this association. Included were 1068 children from the Generation R Study. Serum Immunoglobulin G (IgG) levels against CMV were measured by ELISA; Tissue transglutaminase type 2 antibody (TG2A) levels with fluorescence enzyme immunoassay (FEIA). Duodenal biopsies, additional Human Leukocyte Antigen (HLA) DQ 2.2, 2.5 and 8 and endomysial antibody (EMA) typing were performed in TG2A positive children. Subclinical CD cases (n=12) had 1.8 fold (95% CI 1.06; 3.1) fewer Vδ1+ T cells which was predominantly observed in CMV seronegative children (p-interaction 0.02), and 2.7 fold (95% CI 1.25; 5.99) more CD57+ T cells than HLA DQ2/-DQ8 positive controls (n=339). Hence, children with subclinical CD have alterations in specific blood T cell subsets that are linked to viral pathology. The observed interaction effect between subclinical CD and CMV may contribute to the understanding of disease pathogenesis.
[Mh] Termos MeSH primário: Antígenos CD57/fisiologia
Doença Celíaca/imunologia
Infecções por Citomegalovirus/imunologia
Receptores de Antígenos de Linfócitos T gama-delta/fisiologia
Linfócitos T Citotóxicos/fisiologia
[Mh] Termos MeSH secundário: Doença Celíaca/complicações
Criança
Pré-Escolar
Infecções por Citomegalovirus/complicações
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CD57 Antigens); 0 (Receptors, Antigen, T-Cell, gamma-delta)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:28954890
[Au] Autor:Seu L; Tidwell C; Timares L; Duverger A; Wagner FH; Goepfert PA; Westfall AO; Sabbaj S; Kutsch O
[Ad] Endereço:Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 lillian.seu@gmail.com okutsch@uab.edu.
[Ti] Título:CD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype.
[So] Source:J Immunol;199(9):3336-3347, 2017 Nov 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The tetraspanin CD151 is a marker of aggressive cell proliferation and invasiveness for a variety of cancer types. Given reports of CD151 expression on T cells, we explored whether CD151 would mark T cells in a hyperactivated state. Consistent with the idea that CD151 could mark a phenotypically distinct T cell subset, it was not uniformly expressed on T cells. CD151 expression frequency was a function of the T cell lineage (CD8 > CD4) and a function of the memory differentiation state (naive T cells < central memory T cells < effector memory T cells < T effector memory RA cells). CD151 and CD57, a senescence marker, defined the same CD28 T cell populations. However, CD151 also marked a substantial CD28 T cell population that was not marked by CD57. Kinome array analysis demonstrated that CD28 CD151 T cells form a subpopulation with a distinct molecular baseline and activation phenotype. Network analysis of these data revealed that cell cycle control and cell death were the most altered process motifs in CD28 CD151 T cells. We demonstrate that CD151 in T cells is not a passive marker, but actively changed the cell cycle control and cell death process motifs of T cells. Consistent with these data, long-term T cell culture experiments in the presence of only IL-2 demonstrated that independent of their CD28 expression status, CD151 T cells, but not CD151 T cells, would exhibit an Ag-independent, hyperresponsive proliferation phenotype. Not unlike its reported function as a tumor aggressiveness marker, CD151 in humans thus marks and enables hyperproliferative T cells.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Proliferação Celular
Regulação da Expressão Gênica/imunologia
Tetraspanina 24/imunologia
[Mh] Termos MeSH secundário: Antígenos CD28/genética
Antígenos CD28/imunologia
Antígenos CD57/genética
Antígenos CD57/imunologia
Senescência Celular/genética
Senescência Celular/imunologia
Regulação da Expressão Gênica/genética
Seres Humanos
Tetraspanina 24/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD151 protein, human); 0 (CD28 Antigens); 0 (CD57 Antigens); 0 (Tetraspanin 24)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700648


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[PMID]:28919490
[Au] Autor:Zhang P; Wang G; Lin Z; Wu Y; Zhang J; Liu M; Lee KKH; Chuai M; Yang X
[Ad] Endereço:Key Laboratory for Regenerative Medicine of the Ministry of Education, Division of Histology & Embryology, Medical College, Jinan University, Guangzhou 510632, China.
[Ti] Título:Alcohol exposure induces chick craniofacial bone defects by negatively affecting cranial neural crest development.
[So] Source:Toxicol Lett;281:53-64, 2017 Nov 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs exposed to ethanol was investigated - using chick embryos and in vitro explant culture as experimental models. We demonstrated that exposure to 2% ethanol induced craniofacial defects, which includes parietal defect, in the developing chick fetus. Immunofluorescent staining revealed that ethanol treatment downregulated Ap-2É‘, Pax7 and HNK-1 expressions by cranial NCCs. Using double-immunofluorescent stainings for Ap-2É‘/pHIS3 and Ap-2É‘/c-Caspase3, we showed that ethanol treatment inhibited cranial NCC proliferation and increased NCC apoptosis, respectively. Moreover, ethanol treatment of the dorsal neuroepithelium increased Laminin, N-Cadherin and Cadherin 6B expressions while Cadherin 7 expression was repressed. In situ hybridization also revealed that ethanol treatment up-regulated Cadherin 6B expression but down-regulated slug, Msx1, FoxD3 and BMP4 expressions. In summary, our experimental results demonstrated that ethanol treatment interferes with the production of cranial NCCs by affecting the proliferation and apoptosis of these cells. In addition, ethanol affected the delamination, epithelial-mesenchymal transition (EMT) and cell migration of cranial NCCs, which may have contributed to the etiology of the craniofacial defects.
[Mh] Termos MeSH primário: Anormalidades Craniofaciais/patologia
Etanol/toxicidade
Regulação da Expressão Gênica no Desenvolvimento
Crista Neural/efeitos dos fármacos
Organogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Proteína Morfogenética Óssea 4/genética
Proteína Morfogenética Óssea 4/metabolismo
Antígenos CD57/genética
Antígenos CD57/metabolismo
Caderinas/genética
Caderinas/metabolismo
Embrião de Galinha
Anormalidades Craniofaciais/induzido quimicamente
Modelos Animais de Doenças
Regulação para Baixo
Transtornos do Espectro Alcoólico Fetal/fisiopatologia
Laminina/genética
Laminina/metabolismo
Crista Neural/patologia
Fator de Transcrição PAX7/genética
Fator de Transcrição PAX7/metabolismo
Fator de Transcrição AP-2/genética
Fator de Transcrição AP-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Morphogenetic Protein 4); 0 (CD57 Antigens); 0 (Cadherins); 0 (Laminin); 0 (PAX7 Transcription Factor); 0 (Transcription Factor AP-2); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


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[PMID]:28844471
[Au] Autor:Long SA; Thorpe J; Herold KC; Ehlers M; Sanda S; Lim N; Linsley PS; Nepom GT; Harris KM
[Ad] Endereço:Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
[Ti] Título:Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.
[So] Source:Cell Immunol;319:3-9, 2017 Sep.
[Is] ISSN:1090-2163
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The immunological mechanism(s) of action whereby teplizumab preserves C-peptide levels in the progression of patients with recent onset type 1 diabetes (T1D) is still not well understood. In the present study, we evaluated the kinetics of T cell modulation in peripheral blood following two 14-day courses of teplizumab therapy one year apart in recent onset T1D participants in the AbATE clinical trial. Transient rises in PD-1+Foxp3+ Treg and potentially anergic (CD57-KLRG1-PD-1+) cells in the circulating CD4 T cell compartment were paralleled by more profound increases in circulating CD8 T cells with traits of exhaustion (CD57-KLRG1+PD-1+, TIGIT+KLRG1+, and persistent down-modulation of CD127). The observed phenotypic changes across cell types were associated with favorable response to treatment in the subgroup of study participants that did not develop anti-drug antibodies after the first course of therapy. These findings provide new insights on the duration and complexity of T cell modulation with teplizumab therapy in recent onset T1D, and in addition, suggest that coordinated immune mechanisms of tolerance that favor CD4 Treg function and restrain CD4 non-Treg and CD8 T cell activation may contribute to treatment success.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Humanizados/uso terapêutico
Linfócitos T CD8-Positivos/efeitos dos fármacos
Diabetes Mellitus Tipo 1/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Tolerância Imunológica/efeitos dos fármacos
Linfócitos T Reguladores/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Peptídeo C/agonistas
Peptídeo C/genética
Peptídeo C/imunologia
Complexo CD3/genética
Complexo CD3/imunologia
Antígenos CD57/genética
Antígenos CD57/imunologia
Linfócitos T CD8-Positivos/imunologia
Linfócitos T CD8-Positivos/patologia
Criança
Diabetes Mellitus Tipo 1/imunologia
Diabetes Mellitus Tipo 1/patologia
Feminino
Fatores de Transcrição Forkhead/genética
Fatores de Transcrição Forkhead/imunologia
Expressão Gênica
Seres Humanos
Imunomodulação
Imunoterapia/métodos
Subunidade alfa de Receptor de Interleucina-7/genética
Subunidade alfa de Receptor de Interleucina-7/imunologia
Lectinas Tipo C/genética
Lectinas Tipo C/imunologia
Masculino
Receptor de Morte Celular Programada 1/genética
Receptor de Morte Celular Programada 1/imunologia
Receptores Imunológicos/genética
Receptores Imunológicos/imunologia
Linfócitos T Reguladores/imunologia
Linfócitos T Reguladores/patologia
Transativadores/genética
Transativadores/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Humanized); 0 (C-Peptide); 0 (CD3 Complex); 0 (CD57 Antigens); 0 (FOXP3 protein, human); 0 (Forkhead Transcription Factors); 0 (Hypoglycemic Agents); 0 (Interleukin-7 Receptor alpha Subunit); 0 (KLRG1 protein, human); 0 (Lectins, C-Type); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 0 (Receptors, Immunologic); 0 (TIGIT protein, human); 0 (Trans-Activators); S4M959U2IJ (teplizumab)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28802832
[Au] Autor:Streltsova MA; Barsov E; Erokhina SA; Kovalenko EI
[Ad] Endereço:Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya, Moscow 117997, Russia. Electronic address: mstreltsova@mail.ru.
[Ti] Título:Retroviral gene transfer into primary human NK cells activated by IL-2 and K562 feeder cells expressing membrane-bound IL-21.
[So] Source:J Immunol Methods;450:90-94, 2017 Nov.
[Is] ISSN:1872-7905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Natural killer (NK) cells are capable of rapidly recognizing and efficiently killing tumor cells. This makes them a potentially promising agent for cancer immunotherapy. Additional genetic modifications of NK cells may further improve their anti-tumor efficacy. Numerous technical challenges associated with gene delivery into NK cells have significantly tempered this approach. We achieved efficient retroviral vector transduction of primary human NK cells that were stimulated by a combination of IL-2 and engineered K562 cells expressing membrane-bound IL-21. The activated NK cells were in less differentiated state and expressed NK cell activation receptors NKG2D, NKp30, CD16, and were highly HLA-DR-positive. This NK cell population was highly susceptible to the transduction by both GFP- and NGFR-expressing retroviral vectors, with transduction efficiency exceeding 50%. More mature CD57 NK cell population was generally resistant to retroviral vector transduction because of poor response to the stimulation. Our findings may facilitate retroviral vector-mediated genetic engineering of human primary NK cells for future immunotherapies.
[Mh] Termos MeSH primário: Vetores Genéticos
Imunoterapia/métodos
Interleucina-2/metabolismo
Interleucinas/metabolismo
Células Matadoras Naturais/metabolismo
Leucemia Eritroblástica Aguda/terapia
Ativação Linfocitária
Retroviridae/genética
Transdução Genética
Transfecção/métodos
[Mh] Termos MeSH secundário: Antígenos CD57/imunologia
Antígenos CD57/metabolismo
Diferenciação Celular
Técnicas de Cocultura
Células Alimentadoras
Proteínas Ligadas por GPI/imunologia
Proteínas Ligadas por GPI/metabolismo
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Antígenos HLA-DR/imunologia
Antígenos HLA-DR/metabolismo
Seres Humanos
Interleucina-2/imunologia
Interleucinas/imunologia
Células Jurkat
Células K562
Células Matadoras Naturais/imunologia
Leucemia Eritroblástica Aguda/genética
Leucemia Eritroblástica Aguda/imunologia
Leucemia Eritroblástica Aguda/metabolismo
Subfamília K de Receptores Semelhantes a Lectina de Células NK/imunologia
Subfamília K de Receptores Semelhantes a Lectina de Células NK/metabolismo
Receptor 3 Desencadeador da Citotoxicidade Natural/imunologia
Receptor 3 Desencadeador da Citotoxicidade Natural/metabolismo
Proteínas do Tecido Nervoso/genética
Proteínas do Tecido Nervoso/metabolismo
Receptores de IgG/imunologia
Receptores de IgG/metabolismo
Receptores de Fator de Crescimento Neural/genética
Receptores de Fator de Crescimento Neural/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD57 Antigens); 0 (FCGR3B protein, human); 0 (GPI-Linked Proteins); 0 (HLA-DR Antigens); 0 (Interleukin-2); 0 (Interleukins); 0 (KLRK1 protein, human); 0 (NCR3 protein, human); 0 (NGFR protein, human); 0 (NK Cell Lectin-Like Receptor Subfamily K); 0 (Natural Cytotoxicity Triggering Receptor 3); 0 (Nerve Tissue Proteins); 0 (Receptors, IgG); 0 (Receptors, Nerve Growth Factor); 0 (interleukin-21); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


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[PMID]:28586095
[Au] Autor:Makwana N; Foley B; Fernandez S; Lee S; Irish A; Pircher H; Price P
[Ad] Endereço:Pathology & Laboratory Medicine, University of Western Australia, Nedlands, Australia.
[Ti] Título:CMV drives the expansion of highly functional memory T cells expressing NK-cell receptors in renal transplant recipients.
[So] Source:Eur J Immunol;47(8):1324-1334, 2017 Aug.
[Is] ISSN:1521-4141
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cytomegalovirus (CMV) is a common opportunistic infection encountered in renal transplant recipients (RTRs) and may be reactivated without symptoms at any time post-transplant. We describe how active and latent CMV affect T-cell subsets in RTRs who are stable on maintenance therapy. T-cell responses to CMV were assessed in RTRs (n = 54) >2 years post-transplant, and healthy controls (n = 38). Seven RTRs had CMV DNA detectable in plasma. CMV antibody and DNA aligned with increased proportions of CD8 T cells and reduced CD4/CD8 ratios. This paralleled an expansion of effector memory T-cell (T ), terminally differentiated T-cell (T ) and CD57 T cell populations. Expression of NK-cell receptors, LIR-1 and KLRG1 on CD4 and CD8 CD57 T and T cells correlated with elevated interferon-γ and cytotoxic responses to anti-CD3 and increased cytotoxic responses to CMV phosphoprotein (pp) 65 in RTRs who carried CMV DNA. CD8 T cells from all CMV seropositive RTRs responded efficiently to CMV immediate early (IE) -1 peptides. The data show that latent and active CMV infection can alter T-cell subsets in RTRs many years after transplantation, and up-regulate T-cell expression of NK-cell receptors. This may enhance effector responses of CD4 and CD8 T cells against CMV.
[Mh] Termos MeSH primário: Antígenos CD/metabolismo
Infecções por Citomegalovirus/imunologia
Citomegalovirus/imunologia
Memória Imunológica
Transplante de Rim
Lectinas Tipo C/metabolismo
Receptores Imunológicos/metabolismo
Transativadores/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Antígenos CD/genética
Relação CD4-CD8
Antígenos CD57/genética
Antígenos CD57/imunologia
Linfócitos T CD8-Positivos/efeitos dos fármacos
Linfócitos T CD8-Positivos/imunologia
Citomegalovirus/genética
Infecções por Citomegalovirus/virologia
DNA Viral/sangue
Feminino
Genes Precoces
Seres Humanos
Interferon gama/biossíntese
Interferon gama/imunologia
Células Matadoras Naturais/imunologia
Lectinas Tipo C/genética
Receptor B1 de Leucócitos Semelhante a Imunoglobulina
Masculino
Meia-Idade
Peptídeos/farmacologia
Receptores Imunológicos/genética
Receptores de Células Matadoras Naturais/genética
Receptores de Células Matadoras Naturais/metabolismo
Transativadores/genética
Transplantados
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (CD57 Antigens); 0 (DNA, Viral); 0 (KLRG1 protein, human); 0 (LILRB1 protein, human); 0 (Lectins, C-Type); 0 (Leukocyte Immunoglobulin-like Receptor B1); 0 (Peptides); 0 (Receptors, Immunologic); 0 (Receptors, Natural Killer Cell); 0 (Trans-Activators); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1002/eji.201747018


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[PMID]:28481945
[Au] Autor:Verma K; Ogonek J; Varanasi PR; Luther S; Bünting I; Thomay K; Behrens YL; Mischak-Weissinger E; Hambach L
[Ad] Endereço:Dept. of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
[Ti] Título:Human CD8+ CD57- TEMRA cells: Too young to be called "old".
[So] Source:PLoS One;12(5):e0177405, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:End-stage differentiation of antigen-specific T-cells may precede loss of immune responses against e.g. viral infections after allogeneic stem cell transplantation (SCT). Antigen-specific CD8+ T-cells detected by HLA/peptide multimers largely comprise CD45RA-/CCR7- effector memory (TEM) and CD45RA+/CCR7- TEMRA subsets. A majority of terminally differentiated T-cells is considered to be part of the heterogeneous TEMRA subset. The senescence marker CD57 has been functionally described in memory T-cells mainly composed of central memory (TCM) and TEM cells. However, its role specifically in TEMRA cells remained undefined. Here, we investigated the relevance of CD57 to separate human CD8+ TEMRA cells into functionally distinct subsets. CD57- CD8+ TEMRA cells isolated from healthy donors had considerably longer telomeres and showed significantly more BrdU uptake and IFN-γ release upon stimulation compared to the CD57+ counterpart. Cytomegalovirus (CMV) specific T-cells isolated from patients after allogeneic SCT were purified into CD57+ and CD57- TEMRA subsets. CMV specific CD57- TEMRA cells had longer telomeres and a considerably higher CMV peptide sensitivity in BrdU uptake and IFN-γ release assays compared to CD57+ TEMRA cells. In contrast, CD57+ and CD57- TEMRA cells showed comparable peptide specific cytotoxicity. Finally, CD57- CD8+ TEMRA cells partially changed phenotypically into TEM cells and gained CD57 expression, while CD57+ CD8+ TEMRA cells hardly changed phenotypically and showed considerable cell death after in vitro stimulation. To the best of our knowledge, these data show for the first time that CD57 separates CD8+ TEMRA cells into a terminally differentiated CD57+ population and a so far functionally undescribed "young" CD57- TEMRA subset with high proliferative capacity and differentiation plasticity.
[Mh] Termos MeSH primário: Antígenos CD57/imunologia
Linfócitos T CD8-Positivos/imunologia
[Mh] Termos MeSH secundário: Proliferação Celular
Células Cultivadas
Seres Humanos
Memória Imunológica
Subpopulações de Linfócitos T
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD57 Antigens)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177405


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[PMID]:28475279
[Au] Autor:Newhook N; Fudge N; Grant M
[Ad] Endereço:Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
[Ti] Título:NK cells generate memory-type responses to human cytomegalovirus-infected fibroblasts.
[So] Source:Eur J Immunol;47(6):1032-1039, 2017 Jun.
[Is] ISSN:1521-4141
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Natural killer (NK) cells are cytotoxic lymphocytes that selectively respond against abnormal cells. Human cytomegalovirus (HCMV) infection causes expansion of NKG2C CD57 NK cells in vivo and NKG2C NK cells proliferate when cultured with HCMV-infected cells. This raises the possibility of an NK-cell subset selectively responding against a specific pathogen and accruing memory. To test this possibility, we compared proliferation, natural cytotoxicity and interferon-γ (IFN-γ) production of NK cells from HCMV-seropositive and HCMV-seronegative individuals co-cultured with HCMV-infected or uninfected MRC-5 cells. There was no significant difference in proliferation of NK cells from HCMV-seropositive or seronegative individuals against uninfected MRC-5 cells, but significantly more NK cells from the HCMV-seropositive group proliferated in response to HCMV-infected MRC-5 cells. Natural cytotoxicity of NK cells against K562 cells increased following co-culture with HCMV-infected versus uninfected MRC-5 only for the HCMV-seropositive group. After co-culture with HCMV-infected MRC-5 cells, proliferating NK cells from HCMV-seropositive donors selectively produced IFN-γ when re-exposed to HCMV-infected MRC-5 cells. Both NKG2C and NKG2C NK cells proliferated in co-culture with HCMV-infected MRC-5 cells, with the fraction of proliferating NKG2C NK cells directly correlating with the circulating NKG2C fraction. These data illustrate an at least partly NKG2C-independent human NK-cell memory-type response against HCMV.
[Mh] Termos MeSH primário: Infecções por Citomegalovirus/imunologia
Citomegalovirus/imunologia
Fibroblastos/imunologia
Fibroblastos/virologia
Memória Imunológica
Células Matadoras Naturais/imunologia
Ativação Linfocitária
[Mh] Termos MeSH secundário: Antígenos CD57/análise
Antígenos CD57/genética
Proliferação Celular
Técnicas de Cocultura
Infecções por Citomegalovirus/virologia
Seres Humanos
Interferon gama/biossíntese
Interferon gama/imunologia
Células K562
Subfamília C de Receptores Semelhantes a Lectina de Células NK/análise
Subfamília C de Receptores Semelhantes a Lectina de Células NK/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD57 Antigens); 0 (KLRC2 protein, human); 0 (NK Cell Lectin-Like Receptor Subfamily C); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.1002/eji.201646819



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