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  1 / 2070 MEDLINE  
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[PMID]:28671040
[Au] Autor:Zhu L; Feng H; Jin S; Tan M; Gao S; Zhuang H; Hu Z; Wang H; Song Z; Lin B
[Ad] Endereço:1 Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
[Ti] Título:High expressions of BCL6 and Lewis y antigen are correlated with high tumor burden and poor prognosis in epithelial ovarian cancer.
[So] Source:Tumour Biol;39(7):1010428317711655, 2017 Jul.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aberrant regulation of BCL6 plays crucial oncogenic roles in various malignant tumors; howbeit, the function of BCL6 in tumorigenesis of ovarian cancer remains unclear. The aim of this study is to investigate the role of BCL6 in ovarian cancer. The methods of immunohistochemical staining, quantitative real-time polymerase chain reaction, immunocytochemical staining, and gene expression profile enrichment analysis were performed to identify the possible role of BCL6 in ovarian cancer. We observed that the expression of BCL6 was significantly higher in ovarian cancer tissues and correlated with higher tumor burden including advanced International Federation of Gynecology and Obstetrics stages, poor differentiation, Type II ovarian cancer, the presence of >1 cm residual tumor size, and appearance of recurrence or death (all p < 0.05). The expression patterns of Lewis y were similar to these of BCL6. Multivariate Cox analysis demonstrated that advanced International Federation of Gynecology and Obstetrics stage, lymph node metastasis, residual tumor size >1 cm, as well as high expressions of BCL6 and Lewis y antigen were independent factors of worse progression-free survival and overall survival (all p < 0.05). There was a positive correlation of the expressions of BCL6 and Lewis y antigen. The associated genes with BCL6 in response to Lewis y antigen were identified, including four upregulated genes ( SOCS3, STAT1, PPARG, and GADD45A) and three downregulated genes ( ACAN, E2F3, and ZBTB7B). In conclusion, the high expressions of BCL6 and Lewis y antigen are associated with development, high tumor burden, and worse prognosis of ovarian cancer and targeting BCL6 could be a novel therapeutic strategy for ovarian cancer treatment.
[Mh] Termos MeSH primário: Sistema do Grupo Sanguíneo de Lewis/biossíntese
Recidiva Local de Neoplasia/genética
Neoplasias Epiteliais e Glandulares/genética
Neoplasias Ovarianas/genética
Proteínas Proto-Oncogênicas c-bcl-6/biossíntese
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Intervalo Livre de Doença
Resistência a Medicamentos Antineoplásicos/genética
Feminino
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Metástase Linfática
Meia-Idade
Recidiva Local de Neoplasia/patologia
Neoplasias Epiteliais e Glandulares/patologia
Neoplasias Ovarianas/patologia
Prognóstico
Carga Tumoral/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BCL6 protein, human); 0 (Lewis Blood-Group System); 0 (Lewis Y antigen); 0 (Proto-Oncogene Proteins c-bcl-6)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317711655


  2 / 2070 MEDLINE  
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[PMID]:28351593
[Au] Autor:Wang Y; Rong R; Chen H; Zhu M; Wang B; Li X
[Ad] Endereço:Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China; College of Science, Agricultural University of Hebei, Baoding 071001, China.
[Ti] Título:Triazole-linked fluorescent bisboronic acid capable of selective recognition of the Lewis Y antigen.
[So] Source:Bioorg Med Chem Lett;27(9):1983-1988, 2017 05 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cell surface carbohydrates of the Lewis blood group antigens, Lewis X (Le ), Lewis Y (Le ), Lewis A (Le ), and their sialylated derivatives, such as sialy Lewis X (sLe ) and sialy Lewis A (sLe ), play important roles in various recognition processes. These cell surface carbohydrates have also been associated with the development and progression of many types of cancers. Recently, we synthesized four anthracene-based fluorescent bisboronic acid sensors (compounds 2a-d) linked by 'click' chemistry with tethers of different lengths to match the epitope of various Lewis group of sugars. Among the four compounds, 2a appears to have both high sensitivity and selectivity for Le among other carbohydrate antigens.
[Mh] Termos MeSH primário: Antracenos/química
Ácidos Borônicos/química
Corantes Fluorescentes/química
Sistema do Grupo Sanguíneo de Lewis/análise
Triazóis/química
[Mh] Termos MeSH secundário: Antracenos/metabolismo
Antígenos Glicosídicos Associados a Tumores/análise
Antígenos Glicosídicos Associados a Tumores/metabolismo
Ácidos Borônicos/metabolismo
Linhagem Celular Tumoral
Corantes Fluorescentes/metabolismo
Seres Humanos
Sistema do Grupo Sanguíneo de Lewis/metabolismo
Microscopia de Fluorescência
Neoplasias/metabolismo
Oligossacarídeos/análise
Oligossacarídeos/metabolismo
Triazóis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (2-6 sialyl Le(a) antigen); 0 (5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine); 0 (Anthracenes); 0 (Antigens, Tumor-Associated, Carbohydrate); 0 (Boronic Acids); 0 (Fluorescent Dyes); 0 (Lewis Blood-Group System); 0 (Lewis Y antigen); 0 (Oligosaccharides); 0 (Triazoles); EH46A1TLD7 (anthracene)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


  3 / 2070 MEDLINE  
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[PMID]:28346931
[Au] Autor:Kunz C; Rudloff S
[Ti] Título:Compositional Analysis and Metabolism of Human Milk Oligosaccharides in Infants.
[So] Source:Nestle Nutr Inst Workshop Ser;88:137-147, 2017.
[Is] ISSN:1664-2155
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:It is a great success that biotechnological means are available today to produce amounts of single human milk oligosaccharides (HMOs) in a purity which allows performing metabolic and functional studies even in humans. As recent data indicate that there is a link between the Lewis blood group and the secretor status of an individual and certain inflammatory diseases, this review will also focus on the metabolic fate of secretor- and Lewis blood group-specific components. We conclude that there is no simple urinary or fecal excretion pattern of HMOs, although the pattern in urine often reflects the mother's secretor/nonsecretor status. However, there are deviations for single HMOs which deserve special attention. In feces, the variation in excretion is much higher than in urine, which may be caused by variations in the infant's intestinal microbiota. A gradual decrease in HMO excretion with time as proposed earlier does not take place as even after 7 months of exclusive breastfeeding often intact HMOs can be detected in feces and urine. In addition, we found that whenever oligosaccharides were detected in feces, LNT, the major core structure of HMOs, was present. Hence, our data do not support speculations that LNT is a preferable source for the microbiota.
[Mh] Termos MeSH primário: Leite Humano/química
Oligossacarídeos/análise
Oligossacarídeos/metabolismo
[Mh] Termos MeSH secundário: Fezes/química
Feminino
Microbioma Gastrointestinal/fisiologia
Seres Humanos
Inflamação/sangue
Sistema do Grupo Sanguíneo de Lewis
Oligossacarídeos/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Lewis Blood-Group System); 0 (Oligosaccharides)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1159/000455398


  4 / 2070 MEDLINE  
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[PMID]:28279343
[Au] Autor:Hatakeyama M
[Ad] Endereço:Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Max Planck - The University of Tokyo Center for Integrative Inflammology, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama 332-0012, Japan. Electronic address: mhata@m.u-tokyo.ac.jp.
[Ti] Título:A Sour Relationship between BabA and Lewis b.
[So] Source:Cell Host Microbe;21(3):318-320, 2017 03 08.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Helicobacter pylori survives in the hostile acidic environment of the stomach through extensive adaptation. In this issue of Cell Host & Microbe, Bugaytsova et al. (2017) report an acid-responsive, reversible adherence of H. pylori BabA to the gastric mucosa, the strength of which is tuned by dynamic BabA adaptation.
[Mh] Termos MeSH primário: Infecções por Helicobacter
Sistema do Grupo Sanguíneo de Lewis
[Mh] Termos MeSH secundário: Adesinas Bacterianas
Aderência Bacteriana
Mucosa Gástrica/imunologia
Helicobacter pylori
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Adhesins, Bacterial); 0 (Lewis Blood-Group System)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE


  5 / 2070 MEDLINE  
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[PMID]:27757838
[Au] Autor:Aziz F; Gao W; Yan Q
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Liaoning Provincial Core Laboratory of Glycobiology and Glycoengineering, Dalian Medical University, Dalian, People's Republic of China.
[Ti] Título:Fucosyltransferase-4 and Oligosaccharide Lewis Y Antigen as potentially Correlative Biomarkers of Helicobacter pylori CagA Associated Gastric Cancer.
[So] Source:Pathol Oncol Res;23(1):173-179, 2017 Jan.
[Is] ISSN:1532-2807
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:H. pylori cytotoxin associated antigen A (CagA) plays a significant role in the progression of gastric cancer but their effect on fucosylation to develop gastric cancer is unknown. Fucosyltransferase IV (FUT4) is the key enzyme for synthesis of LewisY (LeY) carried by glycoproteins and glycolipids on the cell membrane. Herein, we compare the expression of CagA, p-EGFR, FUT4 and LeY in gastritis (n = 128, 176), gastric ulcer (n = 174, 213), and gastric cancer (n = 323, 261) tissue and serum samples, respectively by IHC and ELISA. Moreover, we investigated the potential correlation of CagA with FUT4 and LeY overexpression through EGFR activation. IHC and ELISA results showed higher positive cases of H. pylori CagA (83, 86 %), p-EGFR (81, 72 %), FUT4 (91, 97 %) and LeY (93, 92 %) in gastric cancer, compared to gastritis and gastric ulcer, H. pylori CagA (58, 67 & 59, 73 %), p-EGFR (52, 63 & 35, 47 %), FUT4 (68, 78 & 67, 82 %) and LeY (62,76 & 65, 85 %), respectively. We found a significant high expression (H-Value) of CagA (1.79, 1.66), p-EGFR (1.53, 1.58), FUT4 (2.14, 1.66) and LeY (1.69, 1.61) in gastric cancer tissues and serum, respectively as compared to chronic gastritis and gastric ulcers, CagA (0.64,1.14), p-EGFR (0.856, 0.678), FUT4 (0.949,1.197) and LeY (0.68,1.008) (P < 0.0001), respectively. Furthermore, H. pylori CagA showed significant correlation with p-EGFR (R-0.62, -0.74), FUT4 (R-0.81, -0.76) and LeY (R-0.82, -0.70) in gastric tissues and serum (P < 0.0001). H. pylori CagA plays key role in the development of gastric cancer with overexpression of FUT4/LeY, serve as potentially correlative biomarkers of H. pylori CagA associated gastric cancer.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Fucosiltransferases/metabolismo
Helicobacter pylori/patogenicidade
Sistema do Grupo Sanguíneo de Lewis/metabolismo
Antígeno Lewis X/metabolismo
Oligossacarídeos/metabolismo
Neoplasias Gástricas/metabolismo
Neoplasias Gástricas/microbiologia
[Mh] Termos MeSH secundário: Feminino
Gastrite/metabolismo
Gastrite/microbiologia
Infecções por Helicobacter/metabolismo
Infecções por Helicobacter/microbiologia
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Lewis Blood-Group System); 0 (Lewis X Antigen); 0 (Lewis Y antigen); 0 (Oligosaccharides); EC 2.4.1.- (FUT4 protein, human); EC 2.4.1.- (Fucosyltransferases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1007/s12253-016-0122-1


  6 / 2070 MEDLINE  
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[PMID]:27723168
[Au] Autor:Yamazaki Y; Watabe N; Obata H; Hara E; Ohmae M; Kimura S
[Ad] Endereço:Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
[Ti] Título:Immune activation with peptide assemblies carrying Lewis y tumor-associated carbohydrate antigen.
[So] Source:J Pept Sci;23(2):189-197, 2017 Feb.
[Is] ISSN:1099-1387
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Molecular assemblies varying morphologies in a wide range from spherical micelle, nanosheet, curved sheet, nanotube and vesicle were prepared and loaded with Lewis y (Le ) tumor-associated carbohydrate antigen on the assembly surface. The molecular assemblies were composed of poly(sarcosine) -block-poly(L-lactic acid) (m = 15 or 50, Lactosome), poly(sarcosine) -block-(D/L-Leu-Aib) (m = 22 or 30, n = 6 or 8) and their combinations. The molecular assemblies carrying Le on the surface were administered in BALB/c nu/nu mice. The major epitopes of the molecular assemblies are commonly Le and poly(sarcosine). IgM productions upon administrations of the molecular assemblies were assayed by ELISA, showing that anti-poly(sarcosine) IgM was highly produced by Lactosome of spherical micelle but with a negligible amount of anti-Le IgM. On the other hand, the nanosheet of the interdigitated monolayer triggered the production of anti-Le IgM but with less anti-poly(sarcosine) IgM production. Taken together, IgM specificity differs according to the molecular environment of the epitopes in the molecular assemblies. The antigenicity of poly(sarcosine) was augmented in polymeric micelle providing loose environment for B cells to penetrate in, whereas a high density of Le on the molecular assembly was required for anti-Le IgM production. The antigenicity of Le is therefore dependent on the molecular assemblies on which Le is displayed on the surface. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Linfócitos B/efeitos dos fármacos
Imunoglobulina M/biossíntese
Sistema do Grupo Sanguíneo de Lewis/farmacologia
Nanotubos/química
Peptídeos/química
Poliésteres/química
Sarcosina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Linfócitos B/imunologia
Composição de Medicamentos
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Imunidade Inata
Imunização
Sistema do Grupo Sanguíneo de Lewis/química
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Micelas
Sarcosina/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin M); 0 (Lewis Blood-Group System); 0 (Lewis Y antigen); 0 (Micelles); 0 (Peptides); 0 (Polyesters); 25951-24-0 (polysarcosine); 459TN2L5F5 (poly(lactide)); Z711V88R5F (Sarcosine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE
[do] DOI:10.1002/psc.2926


  7 / 2070 MEDLINE  
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[PMID]:27535614
[Au] Autor:Aronica A; Avagliano L; Caretti A; Tosi D; Bulfamante GP; Trinchera M
[Ad] Endereço:Department of Health Sciences, San Paolo Hospital Medical School, University of Milan, 20142 Milano, Italy.
[Ti] Título:Unexpected distribution of CA19.9 and other type 1 chain Lewis antigens in normal and cancer tissues of colon and pancreas: Importance of the detection method and role of glycosyltransferase regulation.
[So] Source:Biochim Biophys Acta;1861(1 Pt A):3210-3220, 2017 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: CA19.9 antigen has been assumed as an abundant product of cancer cells, due to the reactivity found by immunohistochemical staining of cancer tissues with anti-CA19.9 antibody. METHODS: Expression and biosynthesis of type 1 chain Lewis antigens in the colon and the pancreas were studied by immunodetection in tissue sections and lysates, quantification of glycosyltransferase transcripts, bisulfite sequencing, and chromatin immunoprecipitation assays. RESULTS: CA19.9 was poorly detectable in normal colon mucosa and almost undetectable in colon cancer, while it was easily detected in the pancreatic ducts, together with Lewis b antigen, under both normal and cancer conditions. B3GALT5 transcripts were down-regulated in colon cancer, while they remained expressed in pancreatic cancer. Even ST3GAL3 transcript appeared well expressed in the pancreas but poorly in the colon, irrespective of normal or cancer conditions. CpG islands flanking B3GALT5 native promoter presented an extremely low degree of methylation in pancreatic cancer with respect to colon cancer. In a DNA region about 1kb away from the B3GALT5 retroviral promoter, a stretch of CG dinucleotides presented a methylation pattern potentially associated with transcription. Such a DNA region and the transcription factor binding site provided overlapping results by chromatin immunoprecipitation assays, corroborating the hypothesis. CONCLUSIONS: CA19.9 appears as a physiological product whose synthesis strongly depends on the tissue specific and epigenetically-regulated expression of B3GALT5 and ST3GAL3. GENERAL SIGNIFICANCE: CA19.9 and other Lewis antigens acquire tumor marker properties in the pancreas due to mechanisms giving rise to reabsorption into vessels and elevation in circulating levels.
[Mh] Termos MeSH primário: Antígenos de Neoplasias/metabolismo
Antígeno CA-19-9/metabolismo
Neoplasias do Colo/metabolismo
Galactosiltransferases/metabolismo
Glicosiltransferases/metabolismo
Sistema do Grupo Sanguíneo de Lewis/metabolismo
Neoplasias Pancreáticas/metabolismo
Sialiltransferases/metabolismo
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Imunoprecipitação da Cromatina
Colo/metabolismo
Colo/patologia
Neoplasias do Colo/patologia
Ilhas de CpG/genética
DNA/genética
Metilação de DNA/genética
Epigênese Genética
Imunofluorescência
Regulação Enzimológica da Expressão Gênica
Seres Humanos
Pâncreas/metabolismo
Pâncreas/patologia
Neoplasias Pancreáticas/patologia
Regiões Promotoras Genéticas
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, Neoplasm); 0 (CA-19-9 Antigen); 0 (Lewis Blood-Group System); 0 (RNA, Messenger); 9007-49-2 (DNA); EC 2.4.- (Glycosyltransferases); EC 2.4.1.- (B3GALT5 protein, human); EC 2.4.1.- (Galactosyltransferases); EC 2.4.99.- (Sialyltransferases); EC 2.4.99.4 (beta-galactoside alpha-2,3-sialyltransferase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE


  8 / 2070 MEDLINE  
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[PMID]:27721143
[Au] Autor:Ryzhov IM; Korchagina EY; Tuzikov AB; Popova IS; Tyrtysh TV; Pazynina GV; Henry SM; Bovin NV
[Ad] Endereço:Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russian Federation.
[Ti] Título:Function-spacer-lipid constructs of Lewis and chimeric Lewis/ABH glycans. Synthesis and use in serological studies.
[So] Source:Carbohydr Res;435:83-96, 2016 Nov 29.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Seven lipophilic constructs containing Lewis (Le , Le , Le ) or chimeric Lewis/ABH (ALe , BLe , ALe , BLe ) glycans were obtained starting from corresponding oligosaccharides in form of 3-aminopropyl glycosides. ALe and BLe pentasaccharides were synthesized via [3 + 1] blockwise approach. The constructs (neoglycolipids, or FSLs) were inserted in erythrocyte membrane, and obtained "kodecytes" were used to map the immunochemical specificity of historical and contemporary monoclonal and polyclonal blood group system Lewis reagents.
[Mh] Termos MeSH primário: Sistema do Grupo Sanguíneo de Lewis/química
Polissacarídeos/síntese química
Polissacarídeos/imunologia
[Mh] Termos MeSH secundário: Anticorpos Monoclonais/metabolismo
Membrana Eritrocítica/imunologia
Seres Humanos
Sistema do Grupo Sanguíneo de Lewis/imunologia
Estrutura Molecular
Polissacarídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Lewis Blood-Group System); 0 (Polysaccharides)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


  9 / 2070 MEDLINE  
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[PMID]:27705835
[Au] Autor:Maeda M; Tani M; Yoshiie T; Vavricka CJ; Kimura Y
[Ad] Endereço:Department of Biofunctional Chemistry, Graduate School of Environmental and Life Science, Okayama University, 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan; Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University, 1-1-1 Tsushima-Naka, Okayama 700-8
[Ti] Título:Structural features of N-glycans linked to glycoproteins expressed in three kinds of water plants: Predominant occurrence of the plant complex type N-glycans bearing Lewis a epitope.
[So] Source:Carbohydr Res;435:50-57, 2016 Nov 29.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The Japanese cedar pollen allergen (Cry j1) and the mountain cedar pollen allergen (Jun a1) are glycosylated with plant complex type N-glycans bearing Lewis a epitope(s) (Galß1-3[Fucα1-4]GlcNAc-). The biological significance of Lewis a type plant N-glycans and their effects on the human immune system remain to be elucidated. Since a substantial amount of such plant specific N-glycans are required to evaluate immunological activity, we have searched for good plant-glycan sources to characterize Lewis a epitope-containing plant N-glycans. In this study, we have found that three water plants, Elodea nuttallii, Egeria densa, and Ceratophyllum demersum, produce glycoproteins bearing Lewis a units. Structural analysis of the N-glycans revealed that almost all glycoproteins expressed in these three water plants predominantly carry plant complex type N-glycans including the Lewis a type, suggesting that these water plants are good sources for preparation of Lewis a type plant N-glycans in substantial amounts.
[Mh] Termos MeSH primário: Cryptomeria/química
Epitopos/química
Sistema do Grupo Sanguíneo de Lewis/química
Polissacarídeos/química
[Mh] Termos MeSH secundário: Alérgenos/química
Sequência de Carboidratos
Seres Humanos
Pólen/química
Pólen/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Epitopes); 0 (Lewis Blood-Group System); 0 (Polysaccharides)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE


  10 / 2070 MEDLINE  
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[PMID]:27566333
[Au] Autor:Bernardo CR; Camargo AVS; Ronchi LS; de Oliveira AP; de Campos Júnior E; Borim AA; Brandão de Mattos CC; Bestetti RB; de Mattos LC
[Ad] Endereço:Immunogenetics Laboratory, Molecular Biology Department, Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000 São José do Rio Preto, SP, Brazil.
[Ti] Título:ABO, Secretor and Lewis histo-blood group systems influence the digestive form of Chagas disease.
[So] Source:Infect Genet Evol;45:170-175, 2016 Nov.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chagas disease, caused by Trypanosoma cruzi, can affect the heart, esophagus and colon. The reasons that some patients develop different clinical forms or remain asymptomatic are unclear. It is believed that tissue immunogenetic markers influence the tropism of T. cruzi for different organs. ABO, Secretor and Lewis histo-blood group systems express a variety of tissue carbohydrate antigens that influence the susceptibility or resistance to diseases. This study aimed to examine the association of ABO, secretor and Lewis histo-blood systems with the clinical forms of Chagas disease. We enrolled 339 consecutive adult patients with chronic Chagas disease regardless of gender (cardiomyopathy: n=154; megaesophagus: n=119; megacolon: n=66). The control group was composed by 488 healthy blood donors. IgG anti-T. cruzi antibodies were detected by ELISA. ABO and Lewis phenotypes were defined by standard hemagglutination tests. Secretor (FUT2) and Lewis (FUT3) genotypes, determined by Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), were used to infer the correct histo-blood group antigens expressed in the gastrointestinal tract. The proportions between groups were compared using the χ2 test with Yates correction and Fisher's exact test and the Odds Ratio (OR) and 95% Confidence Interval (95% CI) were calculated. An alpha error of 5% was considered significant with p-values <0.05 being corrected for multiple comparisons (pc). No statistically significant differences were found for the ABO (X : 2.635; p-value=0.451), Secretor (X : 0.056; p-value=0.812) or Lewis (X : 2.092; p-value=0.351) histo-blood group phenotypes between patients and controls. However, B plus AB Secretor phenotypes were prevalent in pooled data from megaesophagus and megacolon patients (OR: 5.381; 95% CI: 1.230-23.529; p-value=0.011; pc=0.022) in comparison to A plus O Secretor phenotypes. The tissue antigen variability resulting from the combined action of ABO and Secretor histo-blood systems is associated with the digestive forms of Chagas disease.
[Mh] Termos MeSH primário: Sistema do Grupo Sanguíneo ABO
Doença de Chagas/epidemiologia
Fucosiltransferases/genética
Sistema do Grupo Sanguíneo de Lewis
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Doença de Chagas/genética
Doença de Chagas/metabolismo
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ABO Blood-Group System); 0 (Lewis Blood-Group System); EC 2.4.1.- (Fucosyltransferases); EC 2.4.1.65 (3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase); EC 2.4.1.69 (galactoside 2-alpha-L-fucosyltransferase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160828
[St] Status:MEDLINE



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