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Pesquisa : D23.641.399 [Categoria DeCS]
Referências encontradas : 86 [refinar]
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[PMID]:28369152
[Au] Autor:Hornung J; Kogler L; Wolpert S; Freiherr J; Derntl B
[Ad] Endereço:Department of Psychiatry and Psychotherapy, Medical School, University of Tübingen, Tübingen, Germany.
[Ti] Título:The human body odor compound androstadienone leads to anger-dependent effects in an emotional Stroop but not dot-probe task using human faces.
[So] Source:PLoS One;12(4):e0175055, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The androgen derivative androstadienone is a substance found in human sweat and thus is a putative human chemosignal. Androstadienone has been studied with respect to effects on mood states, attractiveness ratings, physiological and neural activation. With the current experiment, we aimed to explore in which way androstadienone affects attention to social cues (human faces). Moreover, we wanted to test whether effects depend on specific emotions, the participants' sex and individual sensitivity to smell androstadienone. To do so, we investigated 56 healthy individuals (thereof 29 females taking oral contraceptives) with two attention tasks on two consecutive days (once under androstadienone, once under placebo exposure in pseudorandomized order). With an emotional dot-probe task we measured visuo-spatial cueing while an emotional Stroop task allowed us to investigate interference control. Our results suggest that androstadienone acts in a sex, task and emotion-specific manner as a reduction in interference processes in the emotional Stroop task was only apparent for angry faces in men under androstadienone exposure. More specifically, men showed a smaller difference in reaction times for congruent compared to incongruent trials. At the same time also women were slightly affected by smelling androstadienone as they classified angry faces more often correctly under androstadienone. For the emotional dot-probe task no modulation by androstadienone was observed. Furthermore, in both attention paradigms individual sensitivity to androstadienone was neither correlated with reaction times nor error rates in men and women. To conclude, exposure to androstadienone seems to potentiate the relevance of angry faces in both men and women in connection with interference control, while processes of visuo-spatial cueing remain unaffected.
[Mh] Termos MeSH primário: Androstadienos/farmacologia
Ira/fisiologia
Expressão Facial
Reconhecimento Facial/fisiologia
Feromônios Humano/farmacologia
Suor/química
[Mh] Termos MeSH secundário: Adolescente
Adulto
Afeto/fisiologia
Anticoncepcionais Orais/farmacologia
Sinais (Psicologia)
Feminino
Seres Humanos
Masculino
Odorantes
Placebos/farmacologia
Tempo de Reação/efeitos dos fármacos
Olfato
Teste de Stroop
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstadienes); 0 (Contraceptives, Oral); 0 (Pheromones, Human); 0 (Placebos); 4075-07-4 (4,16-androstadien-3-one)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175055


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[PMID]:28346117
[Au] Autor:de Groot JH; Semin GR; Smeets MA
[Ad] Endereço:1 Faculty of Social and Behavioral Sciences, Utrecht University, The Netherlands.
[Ti] Título:On the Communicative Function of Body Odors.
[So] Source:Perspect Psychol Sci;12(2):306-324, 2017 Mar.
[Is] ISSN:1745-6924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Humans use multiple senses to navigate the social world, and the sense of smell is arguably the most underestimated one. An intriguing aspect of the sense of smell is its social communicative function. Research has shown that human odors convey information about a range of states (e.g., emotions, sickness) and traits (e.g., individuality, gender). Yet, what underlies the communicability of these states and traits via smell? We fill this explanatory gap with a framework that highlights the dynamic and flexible aspects of human olfactory communication. In particular, we explain how chemical profiles, associative learning (i.e., the systematic co-occurrence of chemical profiles with state- or trait-related information), and top-down contextual influences could interact to shape human odor perception. Our model not only helps to integrate past research on human olfactory communication but it also opens new avenues for future research on this fascinating, yet to date poorly understood, field.
[Mh] Termos MeSH primário: Comunicação
Percepção Olfatória
Feromônios Humano
Percepção Social
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pheromones, Human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1177/1745691616676599


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[PMID]:26820728
[Au] Autor:Mazzatenta A; De Luca C; Di Tano A; Cacchio M; Di Giulio C; Pokorski M
[Ad] Endereço:Physiology and Physiopathology Section, Department of Neuroscience, Imaging and Clinical Science, University of Chieti-Pescara 'G. d'Annunzio', Chieti, Italy.
[Ti] Título:Swelling of Erectile Nasal Tissue Induced by Human Sexual Pheromone.
[So] Source:Adv Exp Med Biol;885:25-30, 2016.
[Is] ISSN:0065-2598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most chemically mediated sexual communication in humans remains uncharacterized. Yet the study of sexual communication is decisive for understanding sexual behavior and evolutive mechanisms in our species. Here we provide the evidence to consider 4,16-androstadien-3-one (AND) as a man's sexual pheromone. Our experiment provides support for the physiological effect of AND on nasal airway resistance (Rna) in women, as assessed by anterior rhinomanometry. We found that AND administration increased the area of turbinate during the ovulatory phase, resulting in an increase of Rna. Thus, we discovered that minute amounts of AND, acting through neuroendocrine brain control, regulate Rna and consequently affect the sexual physiology and behavior. Fascinatingly, this finding provides the evidence of the preservation of chemosexual communication in humans, which it has been largely neglected due to its unconscious perception and concealed nature. Therefore, chemical communication is a plesiomorphic evolutive phenomenon in humans.
[Mh] Termos MeSH primário: Resistência das Vias Respiratórias/efeitos dos fármacos
Androstadienos/farmacologia
Nariz/efeitos dos fármacos
Feromônios Humano/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Resistência das Vias Respiratórias/fisiologia
Feminino
Seres Humanos
Nariz/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstadienes); 0 (Pheromones, Human); 4075-07-4 (4,16-androstadien-3-one)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161109
[Lr] Data última revisão:
161109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160129
[St] Status:MEDLINE
[do] DOI:10.1007/5584_2015_190


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[PMID]:26631728
[Au] Autor:Zhang X; MacDonald BT; Gao H; Shamashkin M; Coyle AJ; Martinez RV; He X
[Ad] Endereço:From the F. M. Kirby Neurobiology Center, Boston Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115 and.
[Ti] Título:Characterization of Tiki, a New Family of Wnt-specific Metalloproteases.
[So] Source:J Biol Chem;291(5):2435-43, 2016 Jan 29.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Wnt family of secreted glycolipoproteins plays pivotal roles in development and human diseases. Tiki family proteins were identified as novel Wnt inhibitors that act by cleaving the Wnt amino-terminal region to inactivate specific Wnt ligands. Tiki represents a new metalloprotease family that is dependent on Mn(2+)/Co(2+) but lacks known metalloprotease motifs. The Tiki extracellular domain shares homology with bacterial TraB/PrgY proteins, known for their roles in the inhibition of mating pheromones. The TIKI/TraB fold is predicted to be distantly related to structures of additional bacterial proteins and may use a core ß-sheet within an α+ß-fold to coordinate conserved residues for catalysis. In this study, using assays for Wnt3a cleavage and signaling inhibition, we performed mutagenesis analyses of human TIKI2 to examine the structural prediction and identify the active site residues. We also established an in vitro assay for TIKI2 protease activity using FRET peptide substrates derived from the cleavage motifs of Wnt3a and Xenopus wnt8 (Xwnt8). We further identified two pairs of potential disulfide bonds that reside outside the ß-sheet catalytic core but likely assist the folding of the TIKI domain. Finally, we systematically analyzed TIKI2 cleavage of the 19 human WNT proteins, of which we identified 10 as potential TIKI2 substrates, revealing the hydrophobic nature of Tiki cleavage sites. Our study provides insights into the Tiki family of proteases and its Wnt substrates.
[Mh] Termos MeSH primário: Regulação Enzimológica da Expressão Gênica
Metaloendopeptidases/química
Proteínas Wnt/química
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Animais
Domínio Catalítico
Cisteína/química
Dissulfetos/química
Transferência Ressonante de Energia de Fluorescência
Células HEK293
Seres Humanos
Interações Hidrofóbicas e Hidrofílicas
Ligantes
Luciferases/metabolismo
Proteínas de Membrana/química
Metaloproteases/química
Mutagênese Sítio-Dirigida
Peptídeos/química
Feromônios Humano/metabolismo
Dobramento de Proteína
Estrutura Secundária de Proteína
Transdução de Sinais
Proteína Wnt3A/química
Xenopus
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Disulfides); 0 (Ligands); 0 (Membrane Proteins); 0 (Peptides); 0 (Pheromones, Human); 0 (WNT3A protein, human); 0 (Wnt Proteins); 0 (Wnt3A Protein); EC 1.13.12.- (Luciferases); EC 3.4.- (Metalloproteases); EC 3.4.- (Tiki1 protein, human); EC 3.4.24.- (Metalloendopeptidases); EC 3.4.24.- (TIKI2 protein, human); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M115.677807


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[PMID]:26453051
[Au] Autor:Mutic S; Parma V; Brünner YF; Freiherr J
[Ad] Endereço:Diagnostic and Interventional Neuroradiology, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany, Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA and smutic@ukaachen.de.
[Ti] Título:You Smell Dangerous: Communicating Fight Responses Through Human Chemosignals of Aggression.
[So] Source:Chem Senses;41(1):35-43, 2016 Jan.
[Is] ISSN:1464-3553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ability to detect conspecifics that represent a potential harm for an individual represents a high survival benefit. Humans communicate socially relevant information using all sensory modalities, including the chemosensory systems. In study 1, we investigated whether the body odor of a stranger with the intention to harm serves as a chemosignal of aggression. Sixteen healthy male participants donated their body odor while engaging in a boxing session characterized by aggression-induction methods (chemosignal of aggression) and while performing an ergometer session (exercise chemosignal). Self-reports on aggression-related physical activity, motivation to harm and angry emotions selectively increased after aggression induction. In study 2, we examined whether receivers smelling such chemosignals experience emotional contagion (e.g., anger) or emotional reciprocity (e.g., anxiety). The aggression and exercise chemosignals were therefore presented to 22 healthy normosmic participants in a double-blind, randomized exposure during which affective/cognitive processing was examined (i.e., emotion recognition task, emotional stroop task). Behavioral results indicate that chemosignals of aggression induce an affective/cognitive modulation compatible with an anxiety reaction in the recipients. These findings are discussed in light of mechanisms of emotional reciprocity as a way to convey not only affective but also motivational information via chemosensory signals in humans.
[Mh] Termos MeSH primário: Agressão/fisiologia
Comunicação não Verbal/fisiologia
Odorantes
Feromônios Humano/fisiologia
Olfato/fisiologia
[Mh] Termos MeSH secundário: Adulto
Ira/fisiologia
Ansiedade/psicologia
Método Duplo-Cego
Exercício/fisiologia
Feminino
Seres Humanos
Masculino
Motivação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pheromones, Human)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151011
[St] Status:MEDLINE
[do] DOI:10.1093/chemse/bjv058


  6 / 86 MEDLINE  
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[PMID]:26852595
[Au] Autor:Bokhan NA; Nevidimova TI
[Ti] Título:[Relationship between sex hormones, pheromones, interleukine production and risk of drug dependence].
[So] Source:Patol Fiziol Eksp Ter;(3):44-6, 2015 Jul-Sep.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Serum steroid hormones and production of proinflammatory cytokines in 109 individuals with substance dependence, 34 occasional users and 78 control subjects were examined. Immaturity of gender as a risk factor for the formation of drug dependence associated with infectious and inflammatory processes was estimated by olfactory pheromone tests.
[Mh] Termos MeSH primário: Hormônios Esteroides Gonadais/sangue
Interleucinas/sangue
Feromônios Humano/sangue
Transtornos Relacionados ao Uso de Substâncias/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:CLINICAL TRIAL; ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Interleukins); 0 (Pheromones, Human)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:160208
[Lr] Data última revisão:
160208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160209
[St] Status:MEDLINE


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[PMID]:25870406
[Au] Autor:de Groot JH; Smeets MA; Rowson MJ; Bulsing PJ; Blonk CG; Wilkinson JE; Semin GR
[Ad] Endereço:Faculty of Social and Behavioral Sciences, Utrecht University.
[Ti] Título:A sniff of happiness.
[So] Source:Psychol Sci;26(6):684-700, 2015 Jun.
[Is] ISSN:1467-9280
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is well known that feelings of happiness transfer between individuals through mimicry induced by vision and hearing. The evidence is inconclusive, however, as to whether happiness can be communicated through the sense of smell via chemosignals. As chemosignals are a known medium for transferring negative emotions from a sender to a receiver, we examined whether chemosignals are also involved in the transmission of positive emotions. Positive emotions are important for overall well-being and yet relatively neglected in research on chemosignaling, arguably because of the stronger survival benefits linked with negative emotions. We observed that exposure to body odor collected from senders of chemosignals in a happy state induced a facial expression and perceptual-processing style indicative of happiness in the receivers of those signals. Our findings suggest that not only negative affect but also a positive state (happiness) can be transferred by means of odors.
[Mh] Termos MeSH primário: Comunicação
Expressão Facial
Felicidade
Odorantes
Feromônios Humano
Olfato
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Autorrelato
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pheromones, Human)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150415
[St] Status:MEDLINE
[do] DOI:10.1177/0956797614566318


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[PMID]:25797832
[Au] Autor:Wallrabenstein I; Gerber J; Rasche S; Croy I; Kurtenbach S; Hummel T; Hatt H
[Ad] Endereço:Department of Cell Physiology, Ruhr University Bochum, Universitätsstr. 150, 44801 Bochum, Germany. Electronic address: ivonne.wallrabenstein@rub.de.
[Ti] Título:The smelling of Hedione results in sex-differentiated human brain activity.
[So] Source:Neuroimage;113:365-73, 2015 Jun.
[Is] ISSN:1095-9572
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A large family of vomeronasal receptors recognizes pheromone cues in many animals including most amphibia, reptiles, rhodents, and other mammals. Humans possess five vomeronasal-type 1 receptor genes (VN1R1-VN1R5), which code for proteins that are functional in recombinant expression systems. We used two different recombinant expression systems and identified Hedione as a ligand for the putative human pheromone receptor VN1R1 expressed in the human olfactory mucosa. Following the ligand identification, we employed functional magnetic resonance imaging (fMRI) in healthy volunteers to characterize the in vivo action of the VN1R1 ligand Hedione. In comparison to a common floral odor (phenylethyl alcohol), Hedione exhibited significantly enhanced activation in limbic areas (amygdala, hippocampus) and elicited a sex-differentiated response in a hypothalamic region that is associated with hormonal release. Utilizing a novel combination of methods, our results indicate that the putative human pheromone receptor VN1R1 is involved in extra-olfactory neuronal activations induced by the odorous substance Hedione. The activation of VN1R1 might play a role in gender-specific modulation of hormonal secretion in humans.
[Mh] Termos MeSH primário: Ciclopentanos/farmacologia
Feromônios Humano/farmacologia
Olfato/fisiologia
[Mh] Termos MeSH secundário: Adulto
Sinalização do Cálcio/efeitos dos fármacos
Fatores Quimiotáticos/genética
Fatores Quimiotáticos/fisiologia
Feminino
Células HEK293
Seres Humanos
Hipotálamo/efeitos dos fármacos
Sistema Límbico/efeitos dos fármacos
Imagem por Ressonância Magnética
Masculino
Mucosa Olfatória/efeitos dos fármacos
Mucosa Olfatória/metabolismo
Reação em Cadeia da Polimerase
Receptores de Feromonas/efeitos dos fármacos
Receptores de Feromonas/genética
Caracteres Sexuais
Transfecção
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chemotactic Factors); 0 (Cyclopentanes); 0 (Pheromones, Human); 0 (Receptors, Pheromone); 0 (VN1R1 protein, human); 0 (methyldihydrojasmonate)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150518
[Lr] Data última revisão:
150518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150324
[St] Status:MEDLINE


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[PMID]:25740891
[Au] Autor:Wyatt TD
[Ad] Endereço:Department of Zoology, University of Oxford, Tinbergen Building, South Parks Road, Oxford OX1 3PS, UK tristram.wyatt@zoo.ox.ac.uk.
[Ti] Título:The search for human pheromones: the lost decades and the necessity of returning to first principles.
[So] Source:Proc Biol Sci;282(1804):20142994, 2015 Apr 07.
[Is] ISSN:1471-2954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:As humans are mammals, it is possible, perhaps even probable, that we have pheromones. However, there is no robust bioassay-led evidence for the widely published claims that four steroid molecules are human pheromones: androstenone, androstenol, androstadienone and estratetraenol. In the absence of sound reasons to test the molecules, positive results in studies need to be treated with scepticism as these are highly likely to be false positives. Common problems include small sample sizes, an overestimate of effect size (as no effect can be expected), positive publication bias and lack of replication. Instead, if we are to find human pheromones, we need to treat ourselves as if we were a newly discovered mammal, and use the rigorous methods already proven successful in pheromone research on other species. Establishing a pheromone relies on demonstration of an odour-mediated behavioural or physiological response, identification and synthesis of the bioactive molecule(s), followed by bioassay confirmation of activity. Likely sources include our sebaceous glands. Comparison of secretions from adult and pre-pubertal humans may highlight potential molecules involved in sexual behaviour. One of the most promising human pheromone leads is a nipple secretion from the areola glands produced by all lactating mothers, which stimulates suckling by any baby not just their own.
[Mh] Termos MeSH primário: Quimiotaxia
Odorantes/análise
Feromônios Humano/isolamento & purificação
[Mh] Termos MeSH secundário: Seres Humanos
Feromônios Humano/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pheromones, Human)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150306
[St] Status:MEDLINE


  10 / 86 MEDLINE  
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[PMID]:25710097
[Au] Autor:Papaloucas M; Kyriazi K; Kouloulias V
[Ad] Endereço:University of Peloponnese, Tripoli, Greece.
[Ti] Título:Pheromones: a new ergogenic aid in sport?
[So] Source:Int J Sports Physiol Perform;10(7):939-40, 2015 Oct.
[Is] ISSN:1555-0273
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nowadays, antidoping laboratories are improving detection methods to confirm the use of forbidden substances. These tests are based both on direct identification of new substances or their metabolites and on indirect evaluation of changes in gene, protein, or metabolite patterns (genomics, proteomics, or metabolomics). The World Anti-Doping Agency (WADA) officially monitors anabolic steroids, hormones, growth factors, ß-agonists, hormone and metabolic modulators, masking agents, street drugs, manipulation of blood and blood components, chemical and physical manipulation, gene doping, stimulants, narcotics, glucocorticosteroids, and ß-blockers. However, several other substances are under review by WADA. Pheromones accomplish the structure and function of life from its first step, while they have an impact on the body's performance. Both testosterone and pheromones have an ergogenic effect that could potentially affect an athlete's performance. The authors share their questions concerning the potential impact of pheromones in sports.
[Mh] Termos MeSH primário: Doping nos Esportes
Substâncias para Melhoria do Desempenho
Feromônios Humano
[Mh] Termos MeSH secundário: Animais
Desempenho Atlético/fisiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Performance-Enhancing Substances); 0 (Pheromones, Human)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151006
[Lr] Data última revisão:
151006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150225
[St] Status:MEDLINE
[do] DOI:10.1123/ijspp.2014-0226



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