Base de dados : MEDLINE
Pesquisa : D23.946 [Categoria DeCS]
Referências encontradas : 7924 [refinar]
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  1 / 7924 MEDLINE  
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[PMID]:27775385
[Au] Autor:Kengwoung-Keumo JJ
[Ad] Endereço:Department of Mathematical Sciences, Cameron University, 2800 West Gore Boulevard, Lawton, OK 73505, United States. email: jkengwou@cameron.edu.
[Ti] Título:Competition between a nonallelopathic phytoplankton and an allelopathic phytoplankton species under predation.
[So] Source:Math Biosci Eng;13(4):787-812, 2016 08 01.
[Is] ISSN:1551-0018
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We propose a model of two-species competition in the chemostat for a single growth-limiting, nonreproducing resource that extends that of Roy [38]. The response functions are specified to be Michaelis-Menten, and there is no predation in Roy's work. Our model generalizes Roy's model to general uptake functions. The competition is exploitative so that species compete by decreasing the common pool of resources. The model also allows allelopathic effects of one toxin-producing species, both on itself (autotoxicity) and on its nontoxic competitor (phytotoxicity). We show that a stable coexistence equilibrium exists as long as (a) there are allelopathic effects and (b) the input nutrient concentration is above a critical value. The model is reconsidered under instantaneous nutrient recycling. We further extend this work to include a zooplankton species as a fourth interacting component to study the impact of predation on the ecosystem. The zooplankton species is allowed to feed only on the two phytoplankton species which are its perfectly substitutable resources. Each of the models is analyzed for boundedness, equilibria, stability, and uniform persistence (or permanence). Each model structure fits very well with some harmful algal bloom observations where the phytoplankton assemblage can be envisioned in two compartments, toxin producing and non-toxic. The Prymnesium parvum literature, where the suppressing effects of allelochemicals are quite pronounced, is a classic example. This work advances knowledge in an area of research becoming ever more important, which is understanding the functioning of allelopathy in food webs.
[Mh] Termos MeSH primário: Ecossistema
Modelos Biológicos
Fitoplâncton/fisiologia
[Mh] Termos MeSH secundário: Animais
Cadeia Alimentar
Proliferação Nociva de Algas
Toxinas Biológicas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Toxins, Biological)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.3934/mbe.2016018


  2 / 7924 MEDLINE  
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[PMID]:29341609
[Au] Autor:Liu JM; Wang ZH; Ma H; Wang S
[Ad] Endereço:Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University , 94 Weijin Road, Tianjin 300071, People's Republic of China.
[Ti] Título:Probing and Quantifying the Food-Borne Pathogens and Toxins: From In Vitro to In Vivo.
[So] Source:J Agric Food Chem;66(5):1061-1066, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Development of real-time and in situ analytical methods for determination of food-borne pathogens and toxins ingested into the human body would be a promising research direction in the food-safety area. The present perspective starts with summarization of the up-to-date progress of the nanomaterial-assisted in vitro detection methods for pathogens and toxins and finally focuses on application of animal bioimaging to in vivo study, including prospective strategies for in vivo quantification of target pathogens or toxins and in vivo investigation of their behaviors inside the living body, with the assistance of real-time and non-invasive optical bioimaging. This perspective provides the advisory direction for food-safety research, from in vitro to in vivo, along with a prospective discussion of the further development roadmap of the food-safety detection techniques, especially the bioimaging-guided methods for investigation and mediation of the food contamination effect to human health.
[Mh] Termos MeSH primário: Contaminação de Alimentos/análise
Inocuidade dos Alimentos/métodos
Toxinas Biológicas/análise
[Mh] Termos MeSH secundário: Animais
Diagnóstico por Imagem/métodos
Microbiologia de Alimentos/métodos
Doenças Transmitidas por Alimentos/microbiologia
Doenças Transmitidas por Alimentos/prevenção & controle
Seres Humanos
Nanoestruturas
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Toxins, Biological)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05225


  3 / 7924 MEDLINE  
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[PMID]:28462700
[Au] Autor:Vurro M; Boari A; Casella F; Zonno MC
[Ad] Endereço:Institute of Sciences of Food Production, National Research Council, Bari, Italy.
[Ti] Título:Fungal Phytotoxins in Sustainable Weed Management.
[So] Source:Curr Med Chem;25(2):268-286, 2018.
[Is] ISSN:1875-533X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fungal phytotoxins are natural secondary metabolites produced by plant pathogenic fungi during host-pathogen interactions. They have received considerable particular attention for elucidating disease etiology, and consequently to design strategies for disease control. Due to wide differences in their chemical structures, these toxic metabolites have different ecological and environmental roles and mechanisms of action. This review aims at summarizing the studies on the possible use of these metabolites as tools in biological and integrated weed management, e.g. as: novel and environmentally friendly herbicides; lead for novel compounds; sources of novel mechanisms of action. Moreover, the limiting factors for utilizing those metabolites in practice will also be briefly discussed.
[Mh] Termos MeSH primário: Fungos/metabolismo
Herbicidas/metabolismo
Toxinas Biológicas/metabolismo
[Mh] Termos MeSH secundário: Herbicidas/química
Plantas/metabolismo
Toxinas Biológicas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Herbicides); 0 (Toxins, Biological)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.2174/0929867324666170426152331


  4 / 7924 MEDLINE  
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[PMID]:27777178
[Au] Autor:Pla D; Sanz L; Sasa M; Acevedo ME; Dwyer Q; Durban J; Pérez A; Rodriguez Y; Lomonte B; Calvete JJ
[Ad] Endereço:Structural and Functional Venomics Laboratory, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain.
[Ti] Título:Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis).
[So] Source:J Proteomics;152:1-12, 2017 01 30.
[Is] ISSN:1876-7737
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bothriechis is a genus of eleven currently recognized slender and arboreal venomous snakes, commonly called palm-pitvipers that range from southern Mexico to northern South America. Despite dietary studies suggesting that palm-pitvipers are generalists with an ontogenetic shift toward endothermic prey, venom proteomic analyses have revealed remarkable divergence between the venoms of the Costa Rican species, B. lateralis, B. schlegelii, B. supraciliaris, and B. nigroviridis. To achieve a more complete picture of the venomic landscape across Bothriechis, the venom proteomes of biodiversity of the northern Middle American highland palm-pitvipers, B. thalassinus, B. aurifer, and B. bicolor from Guatemala, B. marchi from Honduras, and neonate Costa Rican B. lateralis and B. schlegelii, were investigated. B. thalassinus and B. aurifer venoms are comprised by similar toxin arsenals dominated by SVMPs (33-39% of the venom proteome), CTLs (11-16%), BPP-like molecules (10-13%), and CRISPs (5-10%), and are characterized by the absence of PLA proteins. Conversely, the predominant (35%) components of B. bicolor are D49-PLA molecules. The venom proteome of B. marchi is similar to B. aurifer and B. thalassinus in that it is rich in SVMPs and BPPs, but also contains appreciable amounts (14.3%) of PLA s. The major toxin family found in the venoms of both neonate B. lateralis and B. schlegelii, is serine proteinase (SVSP), comprising about 20% of their toxin arsenals. The venom of neonate B. schlegelii is the only palm-pitviper venom where relative high amounts of Kunitz-type (6.3%) and γPLA (5.2%) inhibitors have been identified. Despite notable differences between their proteomes, neonate venoms are more similar to each other than to adults of their respective species. However, the ontogenetic changes taking place in the venom of B. lateralis strongly differ from those that occur in the venom of B. schlegelii. Thus, the ontogenetic change in B. lateralis produces a SVMP-rich venom, whereas in B. schlegelii the age-dependent compositional shift generates a PLA -rich venom. Overall, genus-wide venomics illustrate the high evolvability of palm-pitviper venoms. The integration of the pattern of venom variation across Bothriechis into a phylogenetic and biogeographic framework may lay the foundation for assessing, in future studies, the evolutionary path that led to the present-day variability of the venoms of palm-pitvipers. SIGNIFICANCE: Bothriechis represents a monophyletic basal genus of eleven arboreal palm-pitvipers that range from southern Mexico to northern South America. Despite palm-pitvipers' putative status as diet generalists, previous proteomic analyses have revealed remarkable divergence between the venoms of Costa Rican species, B. lateralis, B. schlegelii, B. supraciliaris, and B. nigroviridis. Our current proteomic study of Guatemalan species, B. thalassinus, B. aurifer, and B. bicolor, Honduran B. marchi, and neonate B. lateralis and B. schlegelii from Costa Rica was undertaken to deepen our understanding of the evolutionary pattern of venom proteome diversity across Bothriechis. Ancestral characters are often, but not always, preserved in an organism's development. Venoms of neonate B. lateralis and B. schlegelii are more similar to each other than to adults of their respective species, suggesting that the high evolvability of palm-pitviper venoms may represent an inherent feature of Bothriechis common ancestor. Our genus-wide data identified four nodes of venom phenotype differentiation across the phylogeny of Bothriechis. Integrated into a phylogenetic and biogeographic framework, the pattern of venom variation across Bothriechis may lay the groundwork to establish whether divergence was driven by selection for efficient resource exploitation in arboreal 'islands', thereby contributing to the ecological speciation of the genus.
[Mh] Termos MeSH primário: Biodiversidade
Venenos de Crotalídeos/química
Proteoma/análise
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Evolução Biológica
Venenos de Crotalídeos/enzimologia
Fosfolipases A2/análise
Filogenia
Proteômica/métodos
Serina Proteases/análise
Toxinas Biológicas/análise
Viperidae
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Crotalid Venoms); 0 (Proteome); 0 (Toxins, Biological); EC 3.1.1.4 (Phospholipases A2); EC 3.4.- (Serine Proteases)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  5 / 7924 MEDLINE  
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[PMID]:29242345
[Au] Autor:Lenarcic T; Albert I; Böhm H; Hodnik V; Pirc K; Zavec AB; Podobnik M; Pahovnik D; Zagar E; Pruitt R; Greimel P; Yamaji-Hasegawa A; Kobayashi T; Zienkiewicz A; Gömann J; Mortimer JC; Fang L; Mamode-Cassim A; Deleu M; Lins L; Oecking C; Feussner I; Mongrand S; Anderluh G; Nürnberger T
[Ad] Endereço:Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
[Ti] Título:Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.
[So] Source:Science;358(6369):1431-1434, 2017 12 15.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Necrosis and ethylene-inducing peptide 1-like (NLP) proteins constitute a superfamily of proteins produced by plant pathogenic bacteria, fungi, and oomycetes. Many NLPs are cytotoxins that facilitate microbial infection of eudicot, but not of monocot plants. Here, we report glycosylinositol phosphorylceramide (GIPC) sphingolipids as NLP toxin receptors. Plant mutants with altered GIPC composition were more resistant to NLP toxins. Binding studies and x-ray crystallography showed that NLPs form complexes with terminal monomeric hexose moieties of GIPCs that result in conformational changes within the toxin. Insensitivity to NLP cytolysins of monocot plants may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding site. We unveil early steps in NLP cytolysin action that determine plant clade-specific toxin selectivity.
[Mh] Termos MeSH primário: Arabidopsis/parasitologia
Citotoxinas/metabolismo
Especificidade de Hospedeiro
Phytophthora/metabolismo
Doenças das Plantas/parasitologia
Pythium/metabolismo
Esfingolipídeos/metabolismo
Toxinas Biológicas/metabolismo
[Mh] Termos MeSH secundário: Sítios de Ligação
Cristalografia por Raios X
Citotoxinas/química
Etilenos/metabolismo
Esfingolipídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Ethylenes); 0 (Sphingolipids); 0 (Toxins, Biological); 91GW059KN7 (ethylene)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1126/science.aan6874


  6 / 7924 MEDLINE  
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[PMID]:29242331
[Au] Autor:Van den Ackerveken G
[Ad] Endereço:Department of Biology, Utrecht University, Utrecht, Netherlands. g.vandenackerveken@uu.nl.
[Ti] Título:How plants differ in toxin-sensitivity.
[So] Source:Science;358(6369):1383-1384, 2017 12 15.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Plantas Geneticamente Modificadas
Plantas
[Mh] Termos MeSH secundário: Toxinas Biológicas
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Toxins, Biological)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1126/science.aar4188


  7 / 7924 MEDLINE  
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[PMID]:29016645
[Au] Autor:Eloot S; Van Biesen W; Roels S; Delrue W; Schepers E; Dhondt A; Vanholder R; Glorieux G
[Ad] Endereço:Department of Nephrology, Ghent University Hospital, Gent, Belgium.
[Ti] Título:Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients.
[So] Source:PLoS One;12(10):e0186010, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM: Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points. The reliability of these studies however entirely depends on how representative these cross-sectional concentrations are. We therefore investigated the variability of predialysis concentrations of uremic toxins over time. METHODS: Prospectively collected predialysis serum samples of the midweek session of week 0, 1, 2, 3, 4, 8, 12, and 16 were analyzed for a panel of uremic toxins in stable chronic HD patients (N = 18) while maintaining dialyzer type and dialysis mode during the study period. RESULTS: Concentrations of the analyzed uremic toxins varied substantially between individuals, but also within stable HD patients (intra-patient variability). For urea, creatinine, beta-2-microglobulin, and some protein-bound uremic toxins, Intra-class Correlation Coefficient (ICC) was higher than 0.7. However, for phosphorus, uric acid, symmetric and asymmetric dimethylarginine, and the protein-bound toxins hippuric acid and indoxyl sulfate, ICC values were below 0.7, implying a concentration variability within the individual patient even exceeding 65% of the observed inter-patient variability. CONCLUSION: Intra-patient variability may affect the interpretation of the association between a single concentration of certain uremic toxins and outcomes. When performing future outcome and interventional studies with uremic toxins other than described here, one should quantify their intra-patient variability and take into account that for solutes with a large intra-patient variability associations could be missed.
[Mh] Termos MeSH primário: Soluções para Hemodiálise/química
Diálise Renal
Insuficiência Renal Crônica/terapia
Toxinas Biológicas/análise
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Análise de Variância
Arginina/análogos & derivados
Arginina/análise
Creatinina/análise
Feminino
Hipuratos/análise
Seres Humanos
Indicã/análise
Masculino
Meia-Idade
Variações Dependentes do Observador
Fósforo/análise
Ureia/análise
Ácido Úrico/análise
Microglobulina-2 beta/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemodialysis Solutions); 0 (Hippurates); 0 (Toxins, Biological); 0 (beta 2-Microglobulin); 0 (uremia middle molecule toxins); 268B43MJ25 (Uric Acid); 27YLU75U4W (Phosphorus); 49787G1ULV (symmetric dimethylarginine); 63CV1GEK3Y (N,N-dimethylarginine); 8W8T17847W (Urea); 94ZLA3W45F (Arginine); AYI8EX34EU (Creatinine); N187WK1Y1J (Indican); TE0865N2ET (hippuric acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186010


  8 / 7924 MEDLINE  
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[PMID]:28931012
[Au] Autor:Heller DM; Tavag M; Hochschild A
[Ad] Endereço:Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, United States of America.
[Ti] Título:CbtA toxin of Escherichia coli inhibits cell division and cell elongation via direct and independent interactions with FtsZ and MreB.
[So] Source:PLoS Genet;13(9):e1007007, 2017 Sep.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The toxin components of toxin-antitoxin modules, found in bacterial plasmids, phages, and chromosomes, typically target a single macromolecule to interfere with an essential cellular process. An apparent exception is the chromosomally encoded toxin component of the E. coli CbtA/CbeA toxin-antitoxin module, which can inhibit both cell division and cell elongation. A small protein of only 124 amino acids, CbtA, was previously proposed to interact with both FtsZ, a tubulin homolog that is essential for cell division, and MreB, an actin homolog that is essential for cell elongation. However, whether or not the toxic effects of CbtA are due to direct interactions with these predicted targets is not known. Here, we genetically separate the effects of CbtA on cell elongation and cell division, showing that CbtA interacts directly and independently with FtsZ and MreB. Using complementary genetic approaches, we identify the functionally relevant target surfaces on FtsZ and MreB, revealing that in both cases, CbtA binds to surfaces involved in essential cytoskeletal filament architecture. We show further that each interaction contributes independently to CbtA-mediated toxicity and that disruption of both interactions is required to alleviate the observed toxicity. Although several other protein modulators are known to target FtsZ, the CbtA-interacting surface we identify represents a novel inhibitory target. Our findings establish CbtA as a dual function toxin that inhibits both cell division and cell elongation via direct and independent interactions with FtsZ and MreB.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Divisão Celular/genética
Proteínas do Citoesqueleto/genética
Proteínas de Escherichia coli/genética
[Mh] Termos MeSH secundário: Proteínas de Bactérias/metabolismo
Proteínas de Transporte/genética
Proteínas do Citoesqueleto/metabolismo
Citoesqueleto/genética
Escherichia coli/genética
Proteínas de Escherichia coli/metabolismo
Plasmídeos/genética
Toxinas Biológicas/genética
Toxinas Biológicas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Carrier Proteins); 0 (CbeA protein, E coli); 0 (Cytoskeletal Proteins); 0 (Escherichia coli Proteins); 0 (FtsZ protein, Bacteria); 0 (Toxins, Biological); 0 (cbtA protein, E coli); 149255-61-8 (MreB protein, E coli)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007007


  9 / 7924 MEDLINE  
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[PMID]:28864897
[Au] Autor:Osipov AV; Meshcheryakova AV; Starkov VG; Ziganshin RK; Oustitch TL; Peters LE; Tsetlin VI; Utkin YN
[Ad] Endereço:Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
[Ti] Título:New paradoxical three-finger toxin from the cobra Naja kaouthia venom: Isolation and characterization.
[So] Source:Dokl Biochem Biophys;475(1):264-266, 2017 Jul.
[Is] ISSN:1608-3091
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:A new three-finger toxin nakoroxin was isolated from the cobra Naja kaouthia venom, and its complete amino acid sequence was established. Nakoroxin belongs to the group of "orphan" toxins, data on the biological activity of which are practically absent. Nakoroxin shows no cytotoxicity and does not inhibit the binding of α-bungarotoxin to nicotinic acetylcholine receptors of muscle and α7 types. However, it potentiates the binding of α-bungarotoxin to the acetylcholine-binding protein from Lymnaea stagnalis. This is the first toxin with such an unusual property.
[Mh] Termos MeSH primário: Venenos Elapídicos/química
Toxinas Biológicas/química
Toxinas Biológicas/isolamento & purificação
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Toxinas Biológicas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Elapid Venoms); 0 (Naja kaouthia venom); 0 (Toxins, Biological)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.1134/S1607672917040068


  10 / 7924 MEDLINE  
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[PMID]:28820009
[Au] Autor:Zhang J; Taniguchi S; Ito H; Iiyama K; Hino M; Katayama T; Kimura M
[Ad] Endereço:a Laboratory of Structural Biology , Graduate School of Systems Life Sciences , Fukuoka , Japan.
[Ti] Título:Expression of a Vibrio parahaemolyticus toxin in Escherichia coli results in chromosomal DNA degradation.
[So] Source:Biosci Biotechnol Biochem;81(10):1937-1940, 2017 Oct.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A toxin-antitoxin system, vp1842/vp1843, locates within a superintegron on the Vibrio parahaemolyticus genome chromosome I whose toxin gene vp1843 encodes a DNA nicking endonuclease. We found that the vp1843 expression in Escherichia coli cells strongly induced chromosomal DNA degradation. On the basis of these observations, we discuss a possible physiological role of vp1842/vp1843 in V. parahaemolyticus.
[Mh] Termos MeSH primário: Cromossomos Bacterianos/genética
DNA Bacteriano/metabolismo
Escherichia coli/genética
Toxinas Biológicas/genética
Vibrio parahaemolyticus/genética
[Mh] Termos MeSH secundário: Escherichia coli/metabolismo
Expressão Gênica
Toxinas Biológicas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Toxins, Biological)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1347486



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde