Base de dados : MEDLINE
Pesquisa : D23.946.580 [Categoria DeCS]
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[PMID]:28987405
[Au] Autor:Botelho MJ; Vale C; Joaquim S; Costa ST; Soares F; Roque C; Matias D
[Ad] Endereço:IPMA, Portuguese Institute for the Sea and Atmosphere, Rua Alfredo Magalhães Ramalho, 6, 1495-006, Lisbon, Portugal; CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas 289, 4050-123, Porto, Portugal. Electronic address: mjbotelho@ipma.pt.
[Ti] Título:Combined effect of temperature and nutritional regime on the elimination of the lipophilic toxin okadaic acid in the naturally contaminated wedge shell Donax trunculus.
[So] Source:Chemosphere;190:166-173, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The influence of nutritional regime and water temperature on depuration rates of OA-group toxins in the wedge shell Donax trunculus was examined by exposing naturally contaminated specimens to three nutritional regimes (microalgae, commercial paste of microalgae, and starvation) for 14 days at 16 °C and 20 °C. Total OA was quantified in the whole soft tissues of the individuals collected in days 2, 4, 6, 8, 10, 12 and 14. Mortality, dry weight, condition index, gross biochemical composition and gametogenic stages were surveyed. Low variation of glycogen and carbohydrates during the experiments suggest that wedge shells were under non-dramatic stress conditions. Wedge shells fed with non-toxic diets showed similar depuration rates being 15 and 38% higher than in starvation, at 16 and 20 °C, respectively. Depuration rates under non-toxic diets at 20 °C were 71% higher than at 16 °C. These results highlight the influence of water temperature on the depuration rate of total OA accumulated by D. trunculus, even when the increase is of only 4 °C, as commonly observed in week time scales in the southern Portuguese coastal waters. These results open the possibility of a faster release of OA in harvested wedge shells translocated to depuration systems when under a slight increase of water temperature.
[Mh] Termos MeSH primário: Bivalves/química
Recuperação e Remediação Ambiental/métodos
Avaliação Nutricional
Ácido Okadáico/isolamento & purificação
Temperatura Ambiente
[Mh] Termos MeSH secundário: Animais
Carboidratos/análise
Dieta/efeitos adversos
Glicogênio/análise
Toxinas Marinhas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Marine Toxins); 1W21G5Q4N2 (Okadaic Acid); 9005-79-2 (Glycogen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


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[PMID]:29181896
[Au] Autor:Yang X; Li S; Wang Z; Lee SMY; Wang LH; Wang R
[Ad] Endereço:State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China.
[Ti] Título:Constraining the Teratogenicity of Pesticide Pollution by a Synthetic Nanoreceptor.
[So] Source:Chem Asian J;13(1):41-45, 2018 Jan 04.
[Is] ISSN:1861-471X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The teratogenicity of the pesticide nereistoxin (NTX) and its derivative thiocyclam (THI) towards aquatic life was dramatically constrained by a synthetic nanoreceptor, cucurbit[7]uril, through selective encapsulation of the pesticides (K of 3.24(±0.31)×10 m and K of 7.46(±0.10)×10 m ), as evidenced by the rate of hatchability, morphology development, and tyrosinase activity of zebrafish larvae incubated with the pesticides (3-300 µm) in the absence and in the presence of 300 µm cucurbit[7]uril, demonstrating the significant potential of the nanoreceptor in managing ecological pollution of these pesticides.
[Mh] Termos MeSH primário: Hidrocarbonetos Aromáticos com Pontes/farmacologia
Compostos Heterocíclicos com 1 Anel/antagonistas & inibidores
Compostos Heterocíclicos com 1 Anel/toxicidade
Imidazóis/farmacologia
Toxinas Marinhas/antagonistas & inibidores
Toxinas Marinhas/toxicidade
Teratogênios/toxicidade
Poluentes Químicos da Água/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Hidrocarbonetos Aromáticos com Pontes/química
Relação Dose-Resposta a Droga
Compostos Heterocíclicos com 1 Anel/química
Imidazóis/química
Larva/efeitos dos fármacos
Toxinas Marinhas/química
Estrutura Molecular
Relação Estrutura-Atividade
Teratogênios/química
Poluentes Químicos da Água/química
Poluentes Químicos da Água/toxicidade
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bridged-Ring Compounds); 0 (Heterocyclic Compounds, 1-Ring); 0 (Imidazoles); 0 (Marine Toxins); 0 (N,N-dimethyl-1,2,3-trithian-5-yl amine); 0 (Teratogens); 0 (Water Pollutants, Chemical); 0 (cucurbit(7)uril); 1631-58-9 (nereistoxin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1002/asia.201701527


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[PMID]:27776236
[Au] Autor:Chen J; Li X; Wang S; Chen F; Cao W; Sun C; Zheng L; Wang X
[Ad] Endereço:Research Center for Marine Ecology, The First Institute of Oceanography, State Oceanic Administration, Qingdao, 266061, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China. Electronic address: craige200
[Ti] Título:Screening of lipophilic marine toxins in marine aquaculture environment using liquid chromatography-mass spectrometry.
[So] Source:Chemosphere;168:32-40, 2017 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to develop an exact mass suspect screening approach to perform finding of multiple lipophilic marine toxins (LMTs) in seawater, suspended particulate matter (SPM), and marine sediment from marine aquaculture area using liquid chromatography-time of flight mass spectrometry (LC-TOF/MS). The method was validated and proven to be reliable for the screening of various LMTs. Then, the method was applied to screen LMTs in marine environmental samples collected from mariculture area of Jiaozhou Bay, China. Okadaic acid (OA), pectenotoxin 2 (PTX2), etc were detected and tentatively identified. Positive detection results were confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and contents of OA and PTX2 in seawater, SPM and marine sediment were also quantified. The mean concentration of OA ranged from 2.71 to 14.06 ng L in seawater and from 0.78 to 3.34 ng g dry weight in marine sediment. The mean concentration of PTX2 ranged from 0.86 to 7.90 ng L in seawater, from 1.56 to 10.67 ng in SPM obtained from 1 L seawater sample and from 0.95 to 2.23 ng g dry weight in marine sediment. The above results suggested that the proposed method was convenient and reliable for the screening of LMTs in different marine environmental samples. In addition, typical LMTs exist in different marine environmental media of the mariculture area of Jiaozhou Bay, China. Follow-up studies should focus on improving current understanding on the environmental behavior of these LMTs in the marine aquaculture environment.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Sedimentos Geológicos/análise
Toxinas Marinhas/análise
Material Particulado/análise
Água do Mar/análise
[Mh] Termos MeSH secundário: Aquicultura
China
Cromatografia Líquida/métodos
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Marine Toxins); 0 (Particulate Matter)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  4 / 3851 MEDLINE  
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[PMID]:29107028
[Au] Autor:Pelin M; Kilcoyne J; Nulty C; Crain S; Hess P; Tubaro A; Sosa S
[Ad] Endereço:Department of Life Sciences, University of Trieste, Via A. Valerio 6, 34127 Trieste, Italy.
[Ti] Título:Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, -2 and -3 in mice.
[So] Source:Toxicol Lett;282:136-146, 2018 Jan 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Azaspiracids (AZAs) are marine algal toxins that can be accumulated by edible shellfish to cause a foodborne gastrointestinal poisoning in humans. In the European Union, only AZA1, -2 and -3 are currently regulated and their concentration in shellfish is determined through their toxic equivalency factors (TEFs) derived from the intraperitoneal lethal potency in mice. Nevertheless, considering the potential human exposure by oral route, AZAs TEFs should be calculated by comparative oral toxicity data. Thus, the acute oral toxicity of AZA1, -2 and -3 was investigated in female CD-1 mice treated with different doses (AZA1: 135-1100µg/kg; AZA2 and AZA3: 300-1100µg/kg) and sacrificed after 24h or 14days. TEFs derived from the median lethal doses (LD ) were 1.0, 0.7 and 0.5, respectively for AZA1, -2 and -3. In fact, after 24h from gavage administration, LD were 443µg/kg (AZA1; 95% CL: 350-561µg/kg), 626µg/kg (AZA2; 95% CL: 430-911µg/kg) and 875µg/kg (AZA3; 95% CL: 757-1010µg/kg). Mice dead more than 5h after the treatment or those sacrificed after 24h (doses: ≥175µg AZA1/kg, ≥500µg AZA2/kg and ≥600µg AZA3/kg) showed enlarged pale liver, while increased serum markers of liver alteration were recorded even at the lowest doses. Blood chemistry revealed significantly increased serum levels of K ions (≥500mg/kg), whereas light microscopy showed tissue changes in the gastrointestinal tract, liver and spleen. No lethality, macroscopic, tissue or haematological changes were recorded two weeks post exposure, indicating reversible toxic effects. LC-MS/MS analysis of the main organs showed a dose-dependency in gastrointestinal absorption of these toxins: at 24h, the highest levels were detected in the stomach and, in descending order, in the intestinal content, liver, small intestine, kidneys, lungs, large intestine, heart as well as detectable traces in the brain. After 14days, AZA1 and AZA2 were still detectable in almost all the organs and intestinal content.
[Mh] Termos MeSH primário: Furanos/toxicidade
Toxinas Marinhas/toxicidade
Piranos/toxicidade
Compostos de Espiro/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Relação Dose-Resposta a Droga
Feminino
Furanos/farmacocinética
Dose Letal Mediana
Toxinas Marinhas/farmacocinética
Camundongos Endogâmicos
Mytilus edulis/química
Especificidade de Órgãos
Piranos/farmacocinética
Compostos de Espiro/farmacocinética
Distribuição Tecidual
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Furans); 0 (Marine Toxins); 0 (Pyrans); 0 (Spiro Compounds); 0 (azaspiracid); 0 (azaspiracid-2); 0 (azaspiracid-3)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171107
[St] Status:MEDLINE


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[PMID]:28892742
[Au] Autor:Karthik R; Manigandan V; Saravanan R
[Ad] Endereço:Department of Medical Biotechnology, Chettinad Academy of Research and Education, Kelambakkam, Chennai-603 103, Tamil Nadu, India.
[Ti] Título:Toxicity, teratogenicity and antibacterial activity of posterior salivary gland (PSG) toxin from the cuttlefish Sepia pharaonis (Ehrenberg, 1831).
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1064:28-35, 2017 Oct 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Toxins from the posterior salivary gland (PSG) of cuttlefishes are known toxins with pronounced toxicity. In the present study, ionic peptide rich PSG toxin from the cuttlefish S. pharaonis was isolated by ion exchange chromatography and purified by Reversed Phase High Performance Liquid Chromatography (RP-HPLC), with active fraction at a retention time of 26min. The net protein content of the PSG toxin was estimated to be 46.6mg at a proximate molecular weight of∼50kDa. Fourier Transform Infrared Spectroscopy (FT-IR) of PSG toxin revealed the presence of alcoholic OH, primary NH, alkyl CH and conjugated CONH functional groups. Circular Dichroism (CD) spectroscopy and K2D analysis of the PSG toxin confirmed the presence of secondary structure with 36.77% α-helix,12.31% ß sheet and 50.92% random coil. Scanning Electron Microscopy (SEM) of the PSG toxin eluted amberlite IRA 900 Cl resin showed surface abrasion and corrosive blebbing. Energy Dispersive X-ray Spectrometry (EDX) analysis of PSG toxin treated resin revealed increase in nitrogen and sulphur content corresponding to amino acid composition. Teratogenicity of PSG toxin against Zebrafish embryo demonstrated developmental malformations and premature hatching at a maximum tolerated dose of 1.25µM. The PSG toxin (50µM) exhibited commendable inhibitory activity with pronounced zone of inhibition against gram E. coli (10mm) and K. pneumonia (10mm). The results strongly demonstrate the toxicity of the ionic peptide rich PSG toxin from S. pharaonis and its exploitation for its promise as a potential antibacterial agent of the future.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Toxinas Marinhas/farmacologia
Toxinas Marinhas/toxicidade
Sepia/química
Teratogênios/toxicidade
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Bactérias/efeitos dos fármacos
Embrião não Mamífero/efeitos dos fármacos
Embrião não Mamífero/patologia
Toxinas Marinhas/química
Toxinas Marinhas/isolamento & purificação
Teratogênios/química
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Marine Toxins); 0 (Teratogens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE


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[PMID]:28673426
[Au] Autor:Prego-Faraldo MV; Vieira LR; Eirin-Lopez JM; Méndez J; Guilhermino L
[Ad] Endereço:CIIMAR/CIMAR - Interdisciplinary Centre of Marine and Environmental Research, Research Group of Ecotoxicology, Stress Ecology and Environmental Health, University of Porto, Porto, Portugal; XENOMAR Group, Department of Cellular and Molecular Biology, University of A Coruña, A Coruña, Spain; Environm
[Ti] Título:Transcriptional and biochemical analysis of antioxidant enzymes in the mussel Mytilus galloprovincialis during experimental exposures to the toxic dinoflagellate Prorocentrum lima.
[So] Source:Mar Environ Res;129:304-315, 2017 Aug.
[Is] ISSN:1879-0291
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The genotoxic and cytotoxic effects of Diarrhetic Shellfish Poisoning (DSP) toxins have been widely investigated in bivalve molluscs, representing the main vectors of these compounds in the Atlantic coast of Europe. DSP toxins are produced by Harmful Algal Blooms (HABs) of Dinophysis and Prorocentrum dinoflagellates, being subsequently accumulated by marine organisms and biomagnified throughout trophic webs. Yet, bivalves display increased resistance to the harmful effects of these toxins during HAB episodes. While previous reports have suggested that such resilience might be the result of an increased activity in the bivalve antioxidant system, very little is still known about the specific mechanism underlying the protective effect observed in these organisms. The present work aims to fill this gap by studying transcriptional expression levels and biochemical activities of antioxidant enzymes in different tissues the mussel Mytilus galloprovincialis during experimental exposures to DSP toxins produced by the dinoflagellate Prorocentrum lima. Results are consistent with the presence of a compensatory mechanism involving a down-regulation in the expression of specific genes encoding antioxidant enzymes [i.e., SuperOxide Dismutase (SOD) and CATalase (CAT)] which is counterbalanced by the up-regulation of other antioxidant genes such as Glutathione S-Transferase pi-1 (GST-pi) and Selenium-dependent Glutathione PeroXidase (Se-GPx), respectively. Enzymatic activity analyses mirror gene expression results, revealing high antioxidant activity levels (consistent with a protective role for the antioxidant system) along with reduced lipid peroxidation (increasing the defense against oxidative stress).
[Mh] Termos MeSH primário: Dinoflagelados/fisiologia
Proliferação Nociva de Algas
Toxinas Marinhas/toxicidade
Mytilus/fisiologia
[Mh] Termos MeSH secundário: Animais
Catalase/metabolismo
Monitoramento Ambiental
Europa (Continente)
Glutationa Peroxidase/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Marine Toxins); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


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[PMID]:28616979
[Au] Autor:Ding L; Qiu J; Li A
[Ad] Endereço:College of Environmental Science and Engineering, Ocean University of China , Qingdao, Shandong 266100, People's Republic of China.
[Ti] Título:Proposed Biotransformation Pathways for New Metabolites of Paralytic Shellfish Toxins Based on Field and Experimental Mussel Samples.
[So] Source:J Agric Food Chem;65(27):5494-5502, 2017 Jul 12.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A seafood poisoning event occurred in Qinhuangdao, China, in April 2016. Subsequently, the causative mussels (Mytilus galloprovincialis) were harvested and analyzed to reveal a high concentration [∼10 758 µg of saxitoxin (STX) equiv kg ] of paralytic shellfish toxins (PSTs), including gonyautoxin (GTX)1/4 and GTX2/3, as well as new metabolites 11-hydroxy-STX (M2), 11,11-dihydroxy-STX (M4), open-ring 11,11-dihydroxy-STX (M6), 11-hydroxy-neosaxitoxin (NEO) (M8), and 11,11-dihydroxy-NEO (M10). To understand the origin and biotransformation pathways of these new metabolites, uncontaminated mussels (M. galloprovincialis) were fed with either of two Alexandrium tamarense strains (ATHK and TIO108) under laboratory conditions. Similar PST metabolites were also detected in mussels from both feeding experiments. Results supposed that 11-hydroxy-C2 toxin (M1) and 11,11-dihydroxy-C2 (M3) are transformed from C2, while 11-hydroxy-C4 toxin (M7) and 11,11-dihydroxy-C4 (M9) are converted from C4. In addition, the metabolites M2, M4, and M6 appear to be products of GTX2/3, and the metabolites M8 and M10 are likely derived from GTX1/4.
[Mh] Termos MeSH primário: Bivalves/química
Toxinas Marinhas/metabolismo
Intoxicação por Frutos do Mar/metabolismo
Frutos do Mar/análise
[Mh] Termos MeSH secundário: Animais
Biotransformação
Bivalves/metabolismo
Dinoflagelados/metabolismo
Toxinas Marinhas/química
Toxinas Marinhas/toxicidade
Estrutura Molecular
Saxitoxina/análogos & derivados
Saxitoxina/química
Saxitoxina/metabolismo
Frutos do Mar/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Marine Toxins); 35523-89-8 (Saxitoxin); 6YRL8BWD9H (neosaxitoxin); 77462-64-7 (gonyautoxins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02101


  8 / 3851 MEDLINE  
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[PMID]:28598977
[Au] Autor:Noyma NP; de Magalhães L; Miranda M; Mucci M; van Oosterhout F; Huszar VLM; Marinho MM; Lima ERA; Lürling M
[Ad] Endereço:Laboratory of Ecology and Physiology of Phytoplankton, Department of Plant Biology, University of Rio de Janeiro State, Rio de Janeiro, Brazil.
[Ti] Título:Coagulant plus ballast technique provides a rapid mitigation of cyanobacterial nuisance.
[So] Source:PLoS One;12(6):e0178976, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cyanobacteria blooms are a risk to environmental health and public safety due to the potent toxins certain cyanobacteria can produce. These nuisance organisms can be removed from water bodies by biomass flocculation and sedimentation. Here, we studied the efficacy of combinations of a low dose coagulant (poly-aluminium chloride-PAC-or chitosan) with different ballast compounds (red soil, bauxite, gravel, aluminium modified zeolite and lanthanum modified bentonite) to remove cyanobacterial biomass from water collected in Funil Reservoir (Brazil). We tested the effect of different cyanobacterial biomass concentrations on removal efficiency. We also examined if zeta potential was altered by treatments. Addition of low doses of PAC and chitosan (1-8 mg Al L-1) to the cyanobacterial suspensions caused flock formation, but did not settle the cyanobacteria. When those low dose coagulants were combined with ballast, effective settling in a dose-dependent way up to 99.7% removal of the flocks could be achieved without any effect on the zeta potential and thus without potential membrane damage. Removal efficacy was influenced by the cyanobacterial biomass and at higher biomass more ballast was needed to achieve good removal. The combined coagulant-ballast technique provides a promising alternative to algaecides in lakes, ponds and reservoirs.
[Mh] Termos MeSH primário: Coagulantes/farmacologia
Cianobactérias/efeitos dos fármacos
Cianobactérias/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Compostos de Alumínio/farmacologia
Toxinas Bacterianas/biossíntese
Biomassa
Brasil
Quitosana/farmacologia
Clorofila/biossíntese
Cianobactérias/metabolismo
Toxinas Marinhas/biossíntese
Microcistinas/biossíntese
Solo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Compounds); 0 (Bacterial Toxins); 0 (Coagulants); 0 (Marine Toxins); 0 (Microcystins); 0 (Soil); 0 (cyanobacterial toxin); 1406-65-1 (Chlorophyll); 9012-76-4 (Chitosan); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178976


  9 / 3851 MEDLINE  
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[PMID]:28554022
[Au] Autor:Liu Y; Yu RC; Kong FZ; Li C; Dai L; Chen ZF; Zhou MJ
[Ad] Endereço:CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.
[Ti] Título:Lipophilic marine toxins discovered in the Bohai Sea using high performance liquid chromatography coupled with tandem mass spectrometry.
[So] Source:Chemosphere;183:380-388, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Some dinoflagellates can produce lipophilic marine toxins, which pose potent threats to seafood consumers. In the Bohai Sea, an important semi-closed inland sea with intensive mariculture industry in China, there is little knowledge concerning lipophilic marine toxins and their potential threats. In this study, net-concentrated phytoplankton samples were periodically collected from 5 typical mariculture zones around the Bohai Sea, including Laishan (LS), Laizhou (LZ), Hangu (HG), Qinhuangdao (QHD) and Huludao (HLD) in 2013 and 2014, and a method using high performance liquid chromatography (HPLC) coupled with a Q-Trap mass spectrometer was applied to analyze seven representative lipophilic marine toxins, including okadaic acid (OA), dinophysistoxin-1 (DTX1), pectenotoxin-2 (PTX2), yessotoxin (YTX), azaspiracid-1 (AZA1), gymnodimine (GYM), and 13-desmethyl spirolide C (desMeC). The method had high sensitivity and repeatability, and exhibited satisfactory recoveries for most of the lipophilic marine toxins (92.1-108%) except for AZA1 (65.8-68.9%). Nearly all the lipophilic marine toxins could be detected in phytoplankton samples from the Bohai Sea. OA, DTX1 and PTX2 were predominant components and present in most of the phytoplankton samples. The maximum content of lipophilic marine toxin in phytoplankton samples concentrated from seawater (OA 464 pg L ; DTX1 783 pg L ; YTX 86.6 pg L ; desMeC 15.6 pg L ; PTX2 1.11 × 10 pg L ) appeared in June 2014. Based on toxins present in phytoplankton samples, it is implied that seafood in the Bohai Sea is more likely to be contaminated by OA group and PTX group toxins, and spring is the high-risk season for toxin contamination.
[Mh] Termos MeSH primário: Dinoflagelados/química
Toxinas Marinhas/análise
Fitoplâncton/química
Alimentos Marinhos/normas
[Mh] Termos MeSH secundário: Animais
China
Cromatografia Líquida de Alta Pressão/métodos
Furanos/análise
Compostos Heterocíclicos com 3 Anéis/análise
Hidrocarbonetos Cíclicos/análise
Interações Hidrofóbicas e Hidrofílicas
Iminas/análise
Ácido Okadáico/análise
Oxocinas/análise
Piranos/análise
Alimentos Marinhos/análise
Compostos de Espiro/análise
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (13-desmethylspirolide C); 0 (Furans); 0 (Heterocyclic Compounds, 3-Ring); 0 (Hydrocarbons, Cyclic); 0 (Imines); 0 (Marine Toxins); 0 (Oxocins); 0 (Pyrans); 0 (Spiro Compounds); 0 (azaspiracid); 1W21G5Q4N2 (Okadaic Acid); 4Q51CVY9O2 (dinophysistoxin 1); 7TV3J97IT8 (gymnodimine); 97564-91-5 (pectenotoxin 2); P6M9FM2L2G (yessotoxin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28551108
[Au] Autor:Chen W; Tuladhar A; Rolle S; Lai Y; Rodriguez Del Rey F; Zavala CE; Liu Y; Rein KS
[Ad] Endereço:Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL 33199, United States.
[Ti] Título:Brevetoxin-2, is a unique inhibitor of the C-terminal redox center of mammalian thioredoxin reductase-1.
[So] Source:Toxicol Appl Pharmacol;329:58-66, 2017 Aug 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Karenia brevis, the Florida red tide dinoflagellate produces a suite of neurotoxins known as the brevetoxins. The most abundant of the brevetoxins PbTx-2, was found to inhibit the thioredoxin-thioredoxin reductase system, whereas the PbTx-3 has no effect on this system. On the other hand, PbTx-2 activates the reduction of small disulfides such as 5,5'-dithio-bis-(2-nitrobenzoic acid) by thioredoxin reductase. PbTx-2 has an α, ß-unsaturated aldehyde moiety which functions as an efficient electrophile and selenocysteine conjugates are readily formed. PbTx-2 blocks the inhibition of TrxR by the inhibitor curcumin, whereas curcumin blocks PbTx-2 activation of TrxR. It is proposed that the mechanism of inhibition of thioredoxin reduction is via the formation of a Michael adduct between selenocysteine and the α, ß-unsaturated aldehyde moiety of PbTx-2. PbTx-2 had no effect on the rates of reactions catalyzed by related enzymes such as glutathione reductase, glutathione peroxidase or glutaredoxin.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/toxicidade
Toxinas Marinhas/toxicidade
Oxocinas/toxicidade
Tiorredoxina Redutase 1/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Curcumina/farmacologia
Relação Dose-Resposta a Droga
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Oxirredução
Domínios Proteicos
Ratos
Selenocisteína
Tiorredoxina Redutase 1/química
Tiorredoxina Redutase 1/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Marine Toxins); 0 (Oxocins); 0 (brevetoxin 2); 0CH9049VIS (Selenocysteine); EC 1.8.1.9 (TXNRD1 protein, human); EC 1.8.1.9 (Thioredoxin Reductase 1); EC 1.8.1.9 (Txnrd1 protein, rat); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE



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