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[PMID]:29399876
[Au] Autor:Martínez-García S; Rodríguez-Martínez S; Cancino-Diaz ME; Cancino-Diaz JC
[Ad] Endereço:Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico.
[Ti] Título:Extracellular proteases of Staphylococcus epidermidis: roles as virulence factors and their participation in biofilm.
[So] Source:APMIS;126(3):177-185, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Staphylococci produce a large number of extracellular proteases, some of which are considered as potential virulence factors. Staphylococcus epidermidis is a causative agent of nosocomial infections in medical devices by the formation of biofilms. It has been proposed that proteases contribute to the different stages of biofilm formation. S. epidermidis secretes a small number of extracellular proteases, such as serine protease Esp, cysteine protease EcpA, and metalloprotease SepA that have a relatively low substrate specificity. Recent findings indicate a significant contribution of extracellular proteases in biofilm formation through the proteolytic inactivation of adhesion molecules. The objective of this work is to provide an overview of the current knowledge of S. epidermidis' extracellular proteases during pathogenicity, especially in the different stages of biofilm formation.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Biofilmes/crescimento & desenvolvimento
Cisteína Proteases/metabolismo
Metaloendopeptidases/metabolismo
Serina Proteases/metabolismo
Staphylococcus epidermidis/enzimologia
[Mh] Termos MeSH secundário: Moléculas de Adesão Celular/metabolismo
Infecção Hospitalar/microbiologia
Infecção Hospitalar/patologia
Seres Humanos
Infecções Estafilocócicas/microbiologia
Infecções Estafilocócicas/patologia
Staphylococcus epidermidis/metabolismo
Staphylococcus epidermidis/patogenicidade
Fatores de Virulência/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Cell Adhesion Molecules); 0 (Virulence Factors); EC 3.4.- (Cysteine Proteases); EC 3.4.- (Serine Proteases); EC 3.4.24.- (Metalloendopeptidases); EC 3.4.24.- (SepA protein, Staphylococcus epidermidis)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12805


  2 / 14069 MEDLINE  
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[PMID]:29458554
[Au] Autor:Osaka S; Okuzumi K; Koide S; Tamai K; Sato T; Tanimoto K; Tomita H; Suzuki M; Nagano Y; Shibayama K; Arakawa Y; Nagano N
[Ad] Endereço:1​Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Nagano, Japan.
[Ti] Título:Genetic shifts in methicillin-resistant Staphylococcus aureus epidemic clones and toxin gene profiles in Japan: comparative analysis among pre-epidemic, epidemic and post-epidemic phases.
[So] Source:J Med Microbiol;67(3):392-399, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The decline in methicillin-resistant Staphylococcus aureus (MRSA) isolation rates has become a general observation worldwide, including Japan. We hypothesized that some genetic shift in MRSA might cause this phenomenon, and therefore we investigated the genetic profiles among MRSA clinical isolates obtained from three different epidemic phases in Japan. METHODOLOGY: A total of 353 MRSA isolates were selected from 202 medical facilities in 1990 (pre-epidemic phase), 2004 (epidemic phase) and 2016 (post-epidemic phase). Molecular typing was performed by PCR detection of 22 genes using the polymerase chain reaction (PCR)-based ORF typing (POT) system, including an additional eight genes including small genomic islets and seven toxin genes. RESULTS: Isolates with a POT1 of score 93, identified as presumed clonal complex (pCC)5-staphylococcal cassette chromosome mec (SCCmec) type II including ST5-SCCmec type II New York/Japan clone, represented the major epidemic MRSA lineage in 1990 and 2004. In 2016, however, a marked decrease in isolates with a POT1 score of 93, along with changes in the epidemiology of toxin genes carried, was noted, where the carriers of tst genes including the tst-sec combination were markedly reduced, and those possessing the seb gene alone were markedly increased. Rather, isolates with a POT1 score of 106, including pCC1 or pCC8 among the isolates with SCCmec type IV, which often links to community-associated MRSA, were predominant. Interestingly, the pCC1 and pCC8 lineages were related to sea and tst-sec carriage, respectively. CONCLUSIONS: Over time, a transition in MRSA genetic profiles from a POT1 score of 93 in 1990 and 2004 to 106 in 2014 was found in Japan.
[Mh] Termos MeSH primário: Toxinas Bacterianas/genética
Epidemias
Deriva Genética
Staphylococcus aureus Resistente à Meticilina/genética
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/microbiologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Infecção Hospitalar/epidemiologia
Exotoxinas/genética
Seres Humanos
Japão/epidemiologia
Leucocidinas/genética
Meticilina/farmacologia
Resistência a Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Testes de Sensibilidade Microbiana
Tipagem Molecular
Fatores de Virulência/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Toxins); 0 (Exotoxins); 0 (Leukocidins); 0 (Virulence Factors); Q91FH1328A (Methicillin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000687


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[PMID]:29458545
[Au] Autor:Song Q; Wu J; Ruan P
[Ad] Endereço:1​Department of Microbiology, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo, Zhejiang Province, PR China.
[Ti] Título:Predominance of community-associated sequence type 59 methicillin-resistant Staphylococcus aureus in a paediatric intensive care unit.
[So] Source:J Med Microbiol;67(3):408-414, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the distribution of molecular types of methicillin-resistant Staphylococcus aureus (MRSA) in a paediatric intensive care unit (PICU) according to their community-associated (CA) and hospital-associated (HA) source of acquisition, and thus assess the degree to which CA-MRSA has been introduced into the PICU. METHODOLOGY: We implemented an MRSA surveillance in a PICU during 2013-2016 and investigated the genetic diversity of the isolates retrospectively using three genetic typing methods, as well as antibiograms and virulence factor profiles.Results/Key findings. From 2684 specimens, we identified 60 MRSA isolates, 43 of which were ST59 CA-MRSA. These 43 ST59 MRSA isolates could be further subtyped into 2 clusters and 7 sporadic isolates by pulsed-field gel electrophoresis, and 3 spa types, which demonstrated the genetic diversity in ST59 MRSA. Phenotypic diversity was also demonstrated among these ST59 MRSA isolates, with 12 virulence factor profiles and 4 antibiograms being identified. Epidemiological information showed that 43 ST59 MRSA isolates were both community-associated (15 isolates) and hospital-associated (28 isolates) and caused colonization and various types of infections in different age groups of children. CONCLUSIONS: Our results show that a predominant ST59 CA-MRSA has been introduced into the PICU to a significant extent. This has caused the ST59 HA-MRSA and CA-MRSA in the PICU to be indistinguishable. Our results also demonstrate that when we are interpreting situations where the causative agents of infections focus on very limited pathogenic clones, combined typing methods and epidemiological information are needed to investigate isolates' genetic and phenotypic diversity to distinguish an outbreak from endemic cases.
[Mh] Termos MeSH primário: Infecções Comunitárias Adquiridas/microbiologia
Infecção Hospitalar/microbiologia
Unidades de Terapia Intensiva Pediátrica
Staphylococcus aureus Resistente à Meticilina/genética
Infecções Estafilocócicas/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Antibacterianos/farmacologia
Técnicas de Tipagem Bacteriana
Criança
Pré-Escolar
Infecções Comunitárias Adquiridas/epidemiologia
Infecção Hospitalar/epidemiologia
DNA Bacteriano/genética
Eletroforese em Gel de Campo Pulsado
Variação Genética
Seres Humanos
Lactente
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Testes de Sensibilidade Microbiana
Tipagem de Sequências Multilocus
Estudos Retrospectivos
Análise de Sequência de DNA
Infecções Estafilocócicas/epidemiologia
Virulência/genética
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 0 (Virulence Factors)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000693


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[PMID]:29241035
[Au] Autor:Lopez CA; Skaar EP
[Ad] Endereço:Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
[Ti] Título:Crossed Wires: Interspecies Interference Blocks Pathogen Colonization.
[So] Source:Cell Host Microbe;22(6):721-723, 2017 12 13.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Commensal bacteria protect against invading pathogens using many strategies. In this issue of Cell Host & Microbe, Paharik et al. (2017) find that a commensal blocks Staphylococcus aureus colonization by producing a signal to shut down virulence.
[Mh] Termos MeSH primário: Infecções Estafilocócicas/microbiologia
Staphylococcus aureus
[Mh] Termos MeSH secundário: Seres Humanos
Simbiose
Virulência
Fatores de Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Virulence Factors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  5 / 14069 MEDLINE  
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[PMID]:28460033
[Au] Autor:Ram S; Shaughnessy J; de Oliveira RB; Lewis LA; Gulati S; Rice PA
[Ad] Endereço:Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
[Ti] Título:Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics.
[So] Source:Pathog Dis;75(4), 2017 Jun 01.
[Is] ISSN:2049-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gonorrhea has become resistant to most conventional antimicrobials used in clinical practice. The global spread of multidrug-resistant isolates of Neisseria gonorrhoeae could lead to an era of untreatable gonorrhea. New therapeutic modalities with novel mechanisms of action that do not lend themselves to the development of resistance are urgently needed. Gonococcal lipooligosaccharide (LOS) sialylation is critical for complement resistance and for establishing infection in humans and experimental mouse models. Here we describe two immunotherapeutic approaches that target LOS sialic acid: (i) a fusion protein that comprises the region in the complement inhibitor factor H (FH) that binds to sialylated gonococci and IgG Fc (FH/Fc fusion protein) and (ii) analogs of sialic acid that are incorporated into LOS but fail to protect the bacterium against killing. Both molecules showed efficacy in the mouse vaginal colonization model of gonorrhea and may represent promising immunotherapeutic approaches to target multidrug-resistant isolates. Disabling key gonococcal virulence mechanisms is an effective therapeutic strategy because the reduction of virulence is likely to be accompanied by a loss of fitness, rapid elimination by host immunity and consequently, decreased transmission.
[Mh] Termos MeSH primário: Gonorreia/prevenção & controle
Lipopolissacarídeos/metabolismo
Neisseria gonorrhoeae/fisiologia
Ácidos Siálicos/metabolismo
Fatores de Virulência/metabolismo
[Mh] Termos MeSH secundário: Animais
Fator H do Complemento/genética
Fator H do Complemento/metabolismo
Modelos Animais de Doenças
Feminino
Fragmentos Fc das Imunoglobulinas/genética
Fragmentos Fc das Imunoglobulinas/metabolismo
Camundongos
Neisseria gonorrhoeae/efeitos dos fármacos
Ligação Proteica
Proteínas Recombinantes de Fusão/metabolismo
Vagina/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin Fc Fragments); 0 (Lipopolysaccharides); 0 (Recombinant Fusion Proteins); 0 (Sialic Acids); 0 (Virulence Factors); 0 (lipid-linked oligosaccharides); 80295-65-4 (Complement Factor H)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/femspd/ftx049


  6 / 14069 MEDLINE  
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[PMID]:29080422
[Au] Autor:Sakata J; Yonekita T; Kawatsu K
[Ad] Endereço:Division of Microbiology Bacteriology Section, Osaka Institute of Public Health, 3-69, Nakamichi 1-chome, Higashinari-ku, Osaka 537-0025, Japan. Electronic address: sakata@iph.osaka.jp.
[Ti] Título:Development of a rapid immunochromatographic assay to detect contamination of raw oysters with enteropathogenic Vibrio parahaemolyticus.
[So] Source:Int J Food Microbiol;264:16-24, 2018 Jan 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) are major virulence factors of enteropathogenic Vibrio parahaemolyticus. TDH and TRH are bacterial exotoxins, and their presence in culture medium serves as a specific marker for detecting this significant pathogen. Here, we developed and evaluated an immunochromatographic assay (TDH/TRH-ICA) to simultaneously or individually detect TDH and TRH. The TDH/TRH-ICA detected TDH in all broth cultures of 47 V. parahaemolyticus strains carrying tdh. The genes encoding TRH are classified as variants trh1 and trh2, and TRH was detected in all broth cultures of 25 V. parahaemolyticus strains carrying trh1 and certain proportion (5/31) of broth cultures of V. parahaemolyticus strains carrying trh2. In contrast, TDH and TRH were not detected in broth cultures of 12 non-enteropathogenic V. parahaemolyticus strains without tdh and trh. It was difficult to detect TRH2 using the TDH/TRH-ICA. However, TRH2 may not serve as a suitable marker for detecting enteropathogenic V. parahaemolyticus, and evidence indicates that TRH2 may not contribute to enteropathogenesis. Further, a screening method using a combination of TDH/TRH-ICA and SPP medium supplemented with 1.5% NaCl (modified-SPP medium) detected oyster samples artificially spiked with 1.1-22 colony-forming units of enteropathogenic V. parahaemolyticus per 25g of oysters within approximately 8.5h, including the enrichment culture. The assay may serve as a method that facilitates the rapid and easy detection of raw oysters contaminated with enteropathogenic V. parahaemolyticus.
[Mh] Termos MeSH primário: Proteínas de Bactérias/análise
Proteínas Hemolisinas/análise
Imunocromatografia/métodos
Ostreidae/microbiologia
Vibrio parahaemolyticus/genética
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/imunologia
Proteínas de Bactérias/genética
Proteínas de Bactérias/imunologia
Toxinas Bacterianas/análise
Toxinas Bacterianas/genética
Toxinas Bacterianas/imunologia
Proteínas Hemolisinas/genética
Proteínas Hemolisinas/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Vibrio parahaemolyticus/classificação
Vibrio parahaemolyticus/isolamento & purificação
Fatores de Virulência/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Bacterial Proteins); 0 (Bacterial Toxins); 0 (Hemolysin Proteins); 0 (Virulence Factors); 0 (thermostable direct hemolysin-related hemolysin protein, Vibrio parahaemolyticus); 135433-21-5 (thermostable direct hemolysin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE


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[PMID]:29293606
[Au] Autor:Ahmad Z; Harvey RM; Paton JC; Standish AJ; Morona R
[Ad] Endereço:Research Centre for Infectious Diseases, Department of Molecular & Cellular Biology, School of Biological Sciences, The University of Adelaide, South Australia, Australia.
[Ti] Título:Role of Streptococcus pneumoniae OM001 operon in capsular polysaccharide production, virulence and survival in human saliva.
[So] Source:PLoS One;13(1):e0190402, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Streptococcus pneumoniae is the leading cause of community-acquired pneumonia in all ages worldwide, and with ever-increasing antibiotic resistance, the understanding of its pathogenesis and spread is as important as ever. Recently, we reported the presence of a Low Molecular Weight Tyrosine Phosphatase (LMWPTP) Spd1837 in the pneumococcus. This protein is encoded in an operon, OM001 with two other genes, with previous work implicating this operon as important for pneumococcal virulence. Thus, we set out to investigate the role of the individual genes in the operon during pneumococcal pathogenesis. As LMWPTPs play a major role in capsular polysaccharide (CPS) biosynthesis in many bacteria, we tested the effect of mutating spd1837 and its adjacent genes, spd1836 and spd1838 on CPS levels. Our results suggest that individual deletion of the genes, including the LMWPTP, did not modulate CPS levels, in multiple conditions, and in different strain backgrounds. Following in vivo studies, Spd1836 was identified as a novel virulence factor during pneumococcal invasive disease, in both the lungs and blood, with this protein alone responsible for the effects of operon's role in virulence. We also showed that a deletion in spd1836, spd1838 or the overall OM001 operon reduced survival in human saliva during the conditions that mimic transmission compared to the wildtype strain. With studies suggesting that survival in human saliva may be important for transmission, this study identifies Spd1836 and Spd1838 as transmission factors, potentially facilitating the spread of the pneumococcus from person to person. Overall, this study hopes to further our understanding of the bacterial transmission that precedes disease and outbreaks.
[Mh] Termos MeSH primário: Óperon
Polissacarídeos/biossíntese
Saliva/microbiologia
Streptococcus pneumoniae/genética
Fatores de Virulência/metabolismo
[Mh] Termos MeSH secundário: Animais
Western Blotting
Eletroforese em Gel de Poliacrilamida
Feminino
Genes Bacterianos
Seres Humanos
Camundongos
Streptococcus pneumoniae/metabolismo
Streptococcus pneumoniae/patogenicidade
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polysaccharides); 0 (Virulence Factors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190402


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[PMID]:28743081
[Au] Autor:Yu Z; Zhang C; Zhou M; Li Q; Li H; Duan W; Li X; Feng Y; Xie J
[Ad] Endereço:Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715
[Ti] Título:Mycobacterium tuberculosis PPE44 (Rv2770c) is involved in response to multiple stresses and promotes the macrophage expression of IL-12 p40 and IL-6 via the p38, ERK, and NF-κB signaling axis.
[So] Source:Int Immunopharmacol;50:319-329, 2017 Sep.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a formidable threat to global public health. The successful intracellular persistence of M. tuberculosis significantly contributes to the intractability of tuberculosis. Proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) are mycobacterial exclusive protein families that widely reported to be involved in the bacterial virulence, physiology and interaction with host. Rv2770c (PPE44), a predicted virulence factor, was up-regulated upon the infected guinea pig lungs. To investigate the role of Rv2770c, we heterologously expressed the PPE44 in the nonpathogenic fast-growing M. smegmatis strain. Subcellular location analysis demonstrated that Rv2770c is a cell wall associated protein, suggestive of a potential candidate involved in host-pathogen interaction. The Rv2770c can enhance M. smegmatis survival within macrophages and under stresses such as H O , SDS, diamide exposure, and low pH condition. M. smegmatis expressing Rv2770c is more virulent as testified by the increased death of macrophages and the increased expression of interlukin-6 (IL-6) and interlukin-12p40 (IL-12p40). Moreover, Rv2770c altered the secretion of IL-6 and IL-12p40 of macrophages via NF-κB, ERK1/2 and p38 MAPK axis. Taken together, this study implicated that Rv2770c was a virulent factor actively engaged in the interaction with host macrophage.
[Mh] Termos MeSH primário: Antígenos de Bactérias/metabolismo
Pulmão/patologia
Macrófagos/imunologia
Infecções por Micobactéria não Tuberculosa/imunologia
Mycobacterium smegmatis/genética
Mycobacterium tuberculosis/imunologia
Tuberculose/imunologia
Fatores de Virulência/metabolismo
[Mh] Termos MeSH secundário: Animais
Antígenos de Bactérias/genética
Dano ao DNA
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Cobaias
Interações Hospedeiro-Patógeno
Seres Humanos
Subunidade p40 da Interleucina-12/metabolismo
Interleucina-6/metabolismo
Pulmão/microbiologia
Sistema de Sinalização das MAP Quinases
Macrófagos/microbiologia
Mycobacterium tuberculosis/genética
NF-kappa B/metabolismo
Transdução de Sinais
Células THP-1
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Interleukin-12 Subunit p40); 0 (Interleukin-6); 0 (NF-kappa B); 0 (PPE44 protein, Mycobacterium tuberculosis); 0 (Virulence Factors); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  9 / 14069 MEDLINE  
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[PMID]:28467378
[Au] Autor:Ali L; Goraya MU; Arafat Y; Ajmal M; Chen JL; Yu D
[Ad] Endereço:College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. liaqatpaksw@yahoo.com.
[Ti] Título:Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches.
[So] Source:Int J Mol Sci;18(5), 2017 May 03.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Quorum-sensing systems control major virulence determinants in , which causes nosocomial infections. The . quorum-sensing systems include several virulence factors that are regulated by the operon, which encodes the cytolysin toxin. In addition, the . Fsr regulator system controls the expression of gelatinase, serine protease, and enterocin O16. The cytolysin and Fsr virulence factor systems are linked to enterococcal diseases that affect the health of humans and other host models. Therefore, there is substantial interest in understanding and targeting these regulatory pathways to develop novel therapies for enterococcal infection control. Quorum-sensing inhibitors could be potential therapeutic agents for attenuating the pathogenic effects of . . Here, we discuss the regulation of cytolysin, the LuxS system, and the Fsr system, their role in . -mediated infections, and possible therapeutic approaches to prevent . infection.
[Mh] Termos MeSH primário: Infecção Hospitalar/microbiologia
Enterococcus faecalis/patogenicidade
Infecções por Bactérias Gram-Positivas/microbiologia
Percepção de Quorum/fisiologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Proteínas de Bactérias/genética
Biofilmes/efeitos dos fármacos
Biofilmes/crescimento & desenvolvimento
Liases de Carbono-Enxofre/genética
Infecção Hospitalar/tratamento farmacológico
Enterococcus faecalis/efeitos dos fármacos
Enterococcus faecalis/genética
Regulação Bacteriana da Expressão Gênica/fisiologia
Infecções por Bactérias Gram-Positivas/tratamento farmacológico
Seres Humanos
Perforina/genética
Percepção de Quorum/efeitos dos fármacos
Virulência
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Virulence Factors); 126465-35-8 (Perforin); EC 4.4.- (Carbon-Sulfur Lyases); EC 4.4.1.21 (LuxS protein, Bacteria)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:29220592
[Au] Autor:Xu WY; Li YJ; Fan C
[Ad] Endereço:a College of Veterinary Medicine, Northeast Agricultural University, Harbin, People's Republic of China.
[Ti] Título:Different loci and mRNA copy number of the increased serum survival gene of Escherichia coli.
[So] Source:Can J Microbiol;64(2):147-154, 2018 Feb.
[Is] ISSN:1480-3275
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:The increased serum survival gene (iss) has been identified as a virulence trait associated with the virulence of Escherichia coli, causing colibacillosis in poultry. However, it remains unclear as to whether iss mRNA copy number and sequence affect virulence. To examine these influences, we assessed the presence of iss, sequence analysis, iss mRNA copy number, and serum resistance. The iss gene was detected in 88 (all) E. coli isolates from different sources, and sequencing identified 16 alleles (32 different loci) and 10 amino acid sequences (10 different loci). Nested polymerase chain reaction improved iss detection. The isolates from sick chickens had >68% livability in serum resistance tests and higher iss mRNA copy number. The iss mRNA copy number highly correlated with mortality and E. coli livability. Student's t tests confirmed the relationship between the different loci to iss transcription, serum resistance, and virulence. These data suggest that iss mRNA copy number and different loci affect the virulence and serum resistance. These findings could be useful in further studies on the prevalence of iss among E. coli isolates and other virulence factors.
[Mh] Termos MeSH primário: Infecções por Escherichia coli/veterinária
Proteínas de Escherichia coli/genética
Escherichia coli/genética
Escherichia coli/patogenicidade
Doenças das Aves Domésticas/microbiologia
RNA Mensageiro/genética
Virulência/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Galinhas
Infecções por Escherichia coli/microbiologia
Infecções por Escherichia coli/mortalidade
Dosagem de Genes
Reação em Cadeia da Polimerase
Aves Domésticas
Doenças das Aves Domésticas/mortalidade
Fatores de Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Escherichia coli Proteins); 0 (Iss protein, E coli); 0 (RNA, Messenger); 0 (Virulence Factors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1139/cjm-2017-0363



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