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[PMID]:29238193
[Au] Autor:Mahmood SK; Razak IA; Ghaji MS; Yusof LM; Mahmood ZK; Rameli MABP; Zakaria ZAB
[Ad] Endereço:Department of Veterinary Preclinical Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), Serdang, Malaysia.
[Ti] Título:In vivo evaluation of a novel nanocomposite porous 3D scaffold in a rabbit model: histological analysis.
[So] Source:Int J Nanomedicine;12:8587-8598, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The healing of load-bearing segmental defects in long bones is a challenge due to the complex nature of the weight that affects the bone part and due to bending, shearing, axial, and torsional forces. An innovative porous 3D scaffolds implant of CaCO aragonite nanocomposite derived from cockle shell was advanced for substitute bone solely for load-bearing cases. The biomechanical characteristics of such materials were designed to withstand cortical bone strength. In promoting bone growth to the implant material, an ideal surface permeability was formed by means of freeze drying and by adding copolymers to the materials. The properties of coating and copolymers supplement were also assessed for bone-implant connection resolutions. To examine the properties of the material in advanced biological system, an experimental trial in an animal model was carried out. Critical sized defect of bone was created in rabbit's radial bone to assess the material for a load-bearing application with a short and extended period assessment with histological evaluation of the incorporated implanted material to the bone of the host. Trials in animal models proved that the material has the capability of enduring load-bearing conditions for long-term use devoid of breaking or generating stress that affects the host bone. Histological examination further confirmed the improved integration of the implanted materials to the host bone with profound bone development into and also above the implanted scaffold, which was attained with negligible reaction of the tissues to a foreign implanted material.
[Mh] Termos MeSH primário: Regeneração Óssea
Substitutos Ósseos
Nanocompostos/química
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Osso e Ossos/fisiologia
Osso e Ossos/cirurgia
Masculino
Teste de Materiais
Porosidade
Coelhos
Tecidos Suporte
Suporte de Carga
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Substitutes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S145663


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[PMID]:28456893
[Au] Autor:Kanazawa M; Tsuru K; Fukuda N; Sakemi Y; Nakashima Y; Ishikawa K
[Ad] Endereço:Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
[Ti] Título:Evaluation of carbonate apatite blocks fabricated from dicalcium phosphate dihydrate blocks for reconstruction of rabbit femoral and tibial defects.
[So] Source:J Mater Sci Mater Med;28(6):85, 2017 Jun.
[Is] ISSN:1573-4838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate in vivo behavior of a carbonate apatite (CO Ap) block fabricated by compositional transformation via a dissolution-precipitation reaction using a calcium hydrogen phosphate dihydrate [DCPD: CaHPO ·2H O] block as a precursor. These blocks were used to reconstruct defects in the femur and tibia of rabbits, using sintered dense hydroxyapatite (HAp) blocks as the control. Both the CO Ap and HAp blocks showed excellent tissue response and good osteoconductivity. HAp block maintained its structure even after 24 weeks of implantation, so no bone replacement of the implant was observed throughout the post-implantation period in either femoral or tibial bone defects. In contrast, CO Ap was resorbed with increasing time after implantation and replaced with new bone. The CO Ap block was resorbed approximately twice as fast at the metaphysis of the proximal tibia than at the epiphysis of the distal femur. The CO Ap block was resorbed at an approximately linear change over time, with complete resorption was estimated by extrapolation of data at approximately 1-1.5 years. Hence, the CO Ap block fabricated in this study has potential value as an ideal artificial bone substitute because of its resorption and subsequent replacement by bone.
[Mh] Termos MeSH primário: Apatitas/química
Substitutos Ósseos
Fosfatos de Cálcio/química
[Mh] Termos MeSH secundário: Animais
Durapatita
Epífises
Fêmur
Próteses e Implantes
Coelhos
Tíbia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apatites); 0 (Bone Substitutes); 0 (Calcium Phosphates); 55326-60-8 (carboapatite); 91D9GV0Z28 (Durapatite); O7TSZ97GEP (calcium phosphate, dibasic, dihydrate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1007/s10856-017-5896-5


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[PMID]:28459244
[Au] Autor:Mahesh L; Kurtzman G; Shukla S
[Ad] Endereço:Private practice, New Delhi, India.
[Ti] Título:Is Residual Bone Height an Absolute Indicator for Simultaneous Implant Placement in Lateral Wall Sinus Grafting?
[So] Source:Compend Contin Educ Dent;38(5):e5-e8, 2017 May.
[Is] ISSN:2158-1797
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Placement of an implant in the posterior maxilla often relies heavily on a variety of procedures that increase the vertical dimensions of available bone. With numerous bone graft substitutes now available and recent advancements having been made in technique, the question arises of whether residual bone height still remains an absolute indicator for simultaneous implant placement in lateral wall sinus grafting. In addition to reviewing the literature, the authors present a case in which a direct sinus lift procedure was performed with simultaneous implant placement. The case report demonstrates how implants can be placed in a severely atrophic posterior maxilla and be successful.
[Mh] Termos MeSH primário: Transplante Ósseo
Implantação Dentária Endo-Óssea/métodos
Implantes Dentários
Maxila/anatomia & histologia
[Mh] Termos MeSH secundário: Adulto
Substitutos Ósseos
Seres Humanos
Hidroxiapatitas
Masculino
Maxila/cirurgia
Membranas Artificiais
Osteotomia/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Substitutes); 0 (Dental Implants); 0 (Hydroxyapatites); 0 (Membranes, Artificial); 0 (cerabone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29025652
[Au] Autor:Lu Y; Li M; Li L; Wei S; Hu X; Wang X; Shan G; Zhang Y; Xia H; Yin Q
[Ad] Endereço:Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou, Guangdong 510515, China; Guangdong Key Laboratory of Orthopaedic Technology and Implant Materials, Key Laboratory of Trauma and Tissue Repair of Tropical Area of PLA, Department of Orthopedics, Guangzhou General Ho
[Ti] Título:High-activity chitosan/nano hydroxyapatite/zoledronic acid scaffolds for simultaneous tumor inhibition, bone repair and infection eradication.
[So] Source:Mater Sci Eng C Mater Biol Appl;82:225-233, 2018 Jan 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Implanted biomaterials combined tumor inhibition and bone repair property are urgently needed to address the huge bone destruction and the high local recurrence following primary surgery in bone tumor therapy. In this work, a high-activity chitosan/nano hydroxyapatite (CS/nHA) scaffold containing zoledronic acid (CS/nHA/Zol) was prepared with a facile method. The prepared CS/nHA/Zol scaffolds exhibited excellent tumor inhibition property towards giant cell tumor of bone (GCT) in vitro through inducing cells apoptosis by up-regulating pro-apoptosis genes expression and reducing the osteoclastic activity of tumor cells by down-regulating osteoclastic genes. Meanwhile, the prepared scaffolds possessed well biocompatibility and osteoinductivity as compared to pure CS/nHA scaffolds. Furthermore, the prepared scaffolds also presented outstanding antibacterial activity against clinical pathogenic S. aureus and E. coli. These overall findings successfully demonstrated the prepared CS/nHA/Zol scaffolds had a multifunction of tumor therapy, bone repair, and antibacterium, which provides a new approach possessed promising advantages in bone tumor therapy.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Substitutos Ósseos/química
Quitosana/química
Difosfonatos/química
Durapatita/química
Imidazóis/química
Nanocompostos/química
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Materiais Biocompatíveis/farmacologia
Materiais Biocompatíveis/toxicidade
Regeneração Óssea/efeitos dos fármacos
Substitutos Ósseos/farmacologia
Células Cultivadas
Técnicas de Cocultura
Eritrócitos/citologia
Eritrócitos/efeitos dos fármacos
Eritrócitos/metabolismo
Escherichia coli/efeitos dos fármacos
Hemólise/efeitos dos fármacos
Seres Humanos
Células Mesenquimais Estromais/citologia
Células Mesenquimais Estromais/efeitos dos fármacos
Células Mesenquimais Estromais/metabolismo
Microscopia Confocal
Microscopia Eletrônica de Varredura
Espectroscopia de Infravermelho com Transformada de Fourier
Staphylococcus aureus/efeitos dos fármacos
Engenharia Tecidual
Tecidos Suporte/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Bone Substitutes); 0 (Diphosphonates); 0 (Imidazoles); 6XC1PAD3KF (zoledronic acid); 9012-76-4 (Chitosan); 91D9GV0Z28 (Durapatite)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


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[PMID]:29175390
[Au] Autor:Zhang X; Jiang W; Liu Y; Zhang P; Wang L; Li W; Wu G; Ge Y; Zhou Y
[Ad] Endereço:Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China; National Engineering Lab for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, Beijing, 10008
[Ti] Título:Human adipose-derived stem cells and simvastatin-functionalized biomimetic calcium phosphate to construct a novel tissue-engineered bone.
[So] Source:Biochem Biophys Res Commun;495(1):1264-1270, 2018 01 01.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To repair bone defects, we evaluate the in-vitro and in-vivo osteogenic activities of a novel tissue-engineered bone (TEB) by elaborately combining biomimetic calcium phosphate (BioCaP) granules with internally-incorporated simvastatin (SIM) and human adipose-derived stem cells (hASCs). First, we constructed BioCaP with SIM internally incorporated (SIM-BioCaP). Then we characterized the morphology and chemical composition of SIM-BioCaP. The release kinetics of SIM was monitored in vitro spectroscopically. Thereafter, we explored the in-vitro cellular responses of hASCs to SIM-BioCaP by performing scanning electron microscopy observation, proliferation assay, alkaline phosphatase (ALP) activity assay, alizarin red staining and real-time PCR. Finally, we investigated the in-vivo osteogenic activities of the novel TEB in a subcutaneous bone induction model in nude mice. We found that SIM was successfully incorporated internally in BioCaP and showed a slow release manner without significantly affecting the attachment and proliferation of hASCs. The released SIM from BioCaP could significantly enhance the proliferation, ALP activities, mineralized nodules formation and osteogenic genes of hASCs. The in-vivo tests showed this TEB could induce new bone formation while the other groups could not. Taken together, the present data show that this novel TEB represented a very promising construct to treat critical-volume bone defects.
[Mh] Termos MeSH primário: Desenvolvimento Ósseo/fisiologia
Fosfatos de Cálcio/química
Transplante de Células-Tronco Mesenquimais/instrumentação
Osteogênese/fisiologia
Sinvastatina/administração & dosagem
Engenharia Tecidual/instrumentação
Tecidos Suporte
[Mh] Termos MeSH secundário: Animais
Substitutos Ósseos
Células Cultivadas
Implantes de Medicamento/administração & dosagem
Implantes de Medicamento/química
Seres Humanos
Transplante de Células-Tronco Mesenquimais/métodos
Células Mesenquimais Estromais/citologia
Células Mesenquimais Estromais/fisiologia
Camundongos
Camundongos Nus
Osteoblastos/citologia
Osteoblastos/fisiologia
Engenharia Tecidual/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bone Substitutes); 0 (Calcium Phosphates); 0 (Drug Implants); 97Z1WI3NDX (calcium phosphate); AGG2FN16EV (Simvastatin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29182139
[Au] Autor:Bojovic N; Raicevic M; Zivanovic D; Ducic S
[Ti] Título:A rare case of aneurymal bone cyst of cuboid bone in a 10-year-old girl.
[So] Source:Acta Orthop Belg;82(4):913-917, 2016 Dec.
[Is] ISSN:0001-6462
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:Aneurysmal bone cysts (ABC) are rare and they represent 1- 1.4 % of all primary bone tumors. ABC of cuboid bone are extremely rare, especially in children. Very few cases have been reported in the literature since 1967. We present a case of pathological fracture of cuboid bone due to an aneurysmal cyst in a 10-year-old girl. Surgery was performed, which included open biopsy with aspiration and intralesional curettage . Bone defect was then filled in by fully synthetic cancellous bone graft substitute consisting of pure ß-tricalcium phosphate. Aneurysmal cyst of cuboid bone with pathological fracture could be successfully treated with pure ß-tricalcium phosphate as a bone graft substitute. This procedure is safe with excellent outcome.Follow up to nearly four years did not show any recurrence.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/uso terapêutico
Cistos Ósseos Aneurismáticos/cirurgia
Substitutos Ósseos/uso terapêutico
Fosfatos de Cálcio/uso terapêutico
Curetagem/métodos
Fraturas Espontâneas/cirurgia
Ossos do Tarso/cirurgia
[Mh] Termos MeSH secundário: Cistos Ósseos Aneurismáticos/complicações
Cistos Ósseos Aneurismáticos/diagnóstico por imagem
Criança
Feminino
Fraturas Espontâneas/diagnóstico por imagem
Fraturas Espontâneas/etiologia
Seres Humanos
Ossos do Tarso/diagnóstico por imagem
Ossos do Tarso/lesões
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Bone Substitutes); 0 (Calcium Phosphates); 0 (beta-tricalcium phosphate)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29182112
[Au] Autor:Rapp M; Grauel F; Wessel LM; Illing P; Kaiser MM
[Ti] Título:Treatment outcome in 60 children with pathological fractures of the humerus caused by juvenile or aneurysmal bone cysts.
[So] Source:Acta Orthop Belg;82(4):723-729, 2016 Dec.
[Is] ISSN:0001-6462
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:The treatment of pathological fractures of the humerus caused by juvenile or aneurysmal bone cysts (JBC/ABC) should be a single approach with a high success rate and low complication rate. This study evaluates how day by day treatment concepts fulfil these aims. Children below 15 years of age with a pathological fracture of the humerus caused by a JBC or ABC between 01.01.2001 and 31.12.2010, were investigated by chart review in four major paediatric trauma centres. Age, gender, fracture localisation, X-ray findings, treatment and outcome - assessed by the Capanna classification (I to IV), were analysed. 60 children [41male, 19 female; mean age: 9 years (4-14 years)] with 43 JBC and 12 ABC were included as well as five cysts, who could not be classified definitively. First treatment was non-operatively in 33 children. Of these 27 cysts did not improve; likewise the supportive installation of cortisone in six patients did not change the outcome. The first treatment consisted of elastic stable intramedullary in 13 children; up to three nail exchanges included. But only six of these reached (nearly) complete resolution (I/II). Overall the combined mechanical and biological treatment with curettage, elastic stable intramedullary nailing, (artificial) bone substitute and in some cases growth factors was performed as the 1st-line treatment in nine patients and further in 2nd or 3rd-line treatments in 13 humeral cysts. More than half of these reached a complete or nearly complete resolution of the cyst (12x I, 5x II, 1x III, 4x IV). Major complications in all operated patients were six nails not removable and two children with upper extremities length differences. Healing rates are low for non-operative treatment, elastic stable intramedullary nailing alone and by using cortisone for cysts resolution in pathological fractures of the humerus. Data support a combined mechanical and biological treatment with curettage, elastic stable intramedullary nailing, (artificial) bone substitute and the use of growth factors.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Cistos Ósseos Aneurismáticos/terapia
Substitutos Ósseos/uso terapêutico
Cortisona/uso terapêutico
Fixação Intramedular de Fraturas/métodos
Fraturas Espontâneas/terapia
Fraturas do Úmero/terapia
[Mh] Termos MeSH secundário: Adolescente
Cistos Ósseos/complicações
Cistos Ósseos/diagnóstico por imagem
Cistos Ósseos/terapia
Cistos Ósseos Aneurismáticos/complicações
Cistos Ósseos Aneurismáticos/diagnóstico por imagem
Pinos Ortopédicos
Criança
Pré-Escolar
Tratamento Conservador
Feminino
Consolidação da Fratura
Fraturas Espontâneas/diagnóstico por imagem
Fraturas Espontâneas/etiologia
Seres Humanos
Fraturas do Úmero/diagnóstico por imagem
Fraturas do Úmero/etiologia
Injeções Intralesionais
Masculino
Radiografia
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Bone Substitutes); V27W9254FZ (Cortisone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:28910401
[Au] Autor:Ehret C; Aid-Launais R; Sagardoy T; Siadous R; Bareille R; Rey S; Pechev S; Etienne L; Kalisky J; de Mones E; Letourneur D; Amedee Vilamitjana J
[Ad] Endereço:Inserm U1026, University of Bordeaux, Tissue Bioengineering, U1026, Bordeaux, France.
[Ti] Título:Strontium-doped hydroxyapatite polysaccharide materials effect on ectopic bone formation.
[So] Source:PLoS One;12(9):e0184663, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies performed using polysaccharide-based matrices supplemented with hydroxyapatite (HA) particles showed their ability to form in subcutaneous and intramuscular sites a mineralized and osteoid tissue. Our objectives are to optimize the HA content in the matrix and to test the combination of HA with strontium (Sr-HA) to increase the matrix bioactivity. First, non-doped Sr-HA powders were combined to the matrix at three different ratios and were implanted subcutaneously for 2 and 4 weeks. Interestingly, matrices showed radiolucent properties before implantation. Quantitative analysis of micro-CT data evidenced a significant increase of mineralized tissue formed ectopically with time of implantation and allowed us to select the best ratio of HA to polysaccharides of 30% (w/w). Then, two Sr-substitution of 8% and 50% were incorporated in the HA powders (8Sr-HA and 50Sr-HA). Both Sr-HA were chemically characterized and dispersed in matrices. In vitro studies performed with human mesenchymal stem cells (MSCs) demonstrated the absence of cytotoxicity of the Sr-doped matrices whatever the amount of incorporated Sr. They also supported osteoblastic differentiation and activated the expression of one late osteoblastic marker involved in the mineralization process i.e. osteopontin. In vivo, subcutaneous implantation of these Sr-doped matrices induced osteoid tissue and blood vessels formation.
[Mh] Termos MeSH primário: Materiais Revestidos Biocompatíveis/farmacologia
Hidroxiapatitas/farmacologia
Células Mesenquimais Estromais/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
Estrôncio/farmacologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Substitutos Ósseos/química
Substitutos Ósseos/farmacologia
Diferenciação Celular/efeitos dos fármacos
Seres Humanos
Teste de Materiais
Células Mesenquimais Estromais/citologia
Camundongos
Meia-Idade
Próteses e Implantes
Propriedades de Superfície
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Substitutes); 0 (Coated Materials, Biocompatible); 0 (Hydroxyapatites); 0 (strontium hydroxyapatite); YZS2RPE8LE (Strontium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184663


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[PMID]:28816974
[Au] Autor:Park JH; Bae YK; Suh SW; Yang JH; Hong JY
[Ad] Endereço:aDepartment of Orthopedics, Korea University Ansan Hospital, Ansan bDepartment of Orthopedics, Korea University Guro Hospital, Seoul, South Korea.
[Ti] Título:Efficacy of cortico/cancellous composite allograft in treatment of cervical spondylosis.
[So] Source:Medicine (Baltimore);96(33):e7803, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This was a prospective comparative study.The aim of this study was to compare the clinical and radiologic outcomes of patients treated with cortico/cancellous composite allograft or autoiliac bone graft in anterior cervical discectomy and fusion.Several methods have been developed to fuse the cervical spine for treatment of cervical spondylosis. Cortico/cancellous composite allograft might be another alternative.A total of 46 patients who underwent surgery for treatment of cervical spondylosis were evaluated between September 2010 and January 2015. The duration of operation, blood loss, perioperative complications, neck disability index (NDI), visual analogue scale (VAS), and fusion rates were compared between the 2 groups.There were no significant differences in clinical or radiologic outcomes between the patients treated with cortico/cancellous composite allograft and those treated with autoiliac bone graft. The 2 groups showed similar improvements in clinical symptoms and fusion rates. Although not statistically significant, the subsidence rate was lower in the cortico/cancellous composite group.Cortico/cancellous composite allograft is an effective alternative to conventional allograft or autograft in anterior cervical discectomy and fusion.
[Mh] Termos MeSH primário: Substitutos Ósseos/uso terapêutico
Discotomia/métodos
Fusão Vertebral/métodos
Espondilose/cirurgia
[Mh] Termos MeSH secundário: Idoso
Aloenxertos
Autoenxertos
Perda Sanguínea Cirúrgica
Substitutos Ósseos/administração & dosagem
Substitutos Ósseos/efeitos adversos
Feminino
Seres Humanos
Masculino
Meia-Idade
Duração da Cirurgia
Estudos Prospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Bone Substitutes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007803


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[PMID]:28753275
[Au] Autor:Sharma R; Kapusetti G; Bhong SY; Roy P; Singh SK; Singh S; Balavigneswaran CK; Mahato KK; Ray B; Maiti P; Misra N
[Ti] Título:Osteoconductive Amine-Functionalized Graphene-Poly(methyl methacrylate) Bone Cement Composite with Controlled Exothermic Polymerization.
[So] Source:Bioconjug Chem;28(9):2254-2265, 2017 Sep 20.
[Is] ISSN:1520-4812
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bone cement has found extensive usage in joint arthroplasty over the last 50 years; still, the development of bone cement with essential properties such as high fatigue resistance, lower exothermic temperature, and bioactivity has been an unsolved problem. In our present work, we have addressed all of the mentioned shortcomings of bone cement by reinforcing it with graphene (GR), graphene oxide (GO), and surface-modified amino graphene (AG) fillers. These nanocomposites have shown hypsochromic shifts, suggesting strong interactions between the filler material and the polymer matrix. AG-based nanohybrids have shown greater osteointegration and lower cytotoxicity compared to other nanohybrids as well as pristine bone cement. They have also reduced oxidative stress on cells, resulting in calcification within 20 days of the implantation of nanohybrids into the rabbits. They have significantly reduced the exothermic curing temperature to body temperature and increased the setting time to facilitate practitioners, suggesting that reaction temperature and settling time can be dynamically controlled by varying the concentration of the filler. Thermal stability and enhanced mechanical properties have been achieved in nanohybrids vis-à-vis pure bone cement. Thus, this newly developed nanocomposite can create natural bonding with bone tissues for improved bioactivity, longer sustainability, and better strength in the prosthesis.
[Mh] Termos MeSH primário: Cimentos para Ossos/química
Grafite/química
Nanocompostos/química
Polimetil Metacrilato/química
[Mh] Termos MeSH secundário: Aminação
Animais
Substitutos Ósseos/química
Linhagem Celular
Seres Humanos
Teste de Materiais
Nanocompostos/ultraestrutura
Osseointegração
Osteogênese
Polimerização
Coelhos
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Cements); 0 (Bone Substitutes); 7782-42-5 (Graphite); 9011-14-7 (Polymethyl Methacrylate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1021/acs.bioconjchem.7b00241



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