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[PMID]: 29211281 [Au] Autor: Sinfiteli PP; Coutinho TCL; Oliveira PRA; Vasques WF; Azevedo LM; Pereira AMB; Tostes MA [Ad] Endereço: Universidade Federal Fluminense, Faculdade de Odontologia, Niterói, RJ, Brasil. [Ti] Título: Effect of fluoride dentifrice and casein phosphopeptide-amorphous calcium phosphate cream with and without fluoride in preventing enamel demineralization in a pH cyclic study. [So] Source: J Appl Oral Sci;25(6):604-611, 2017 Nov-Dec. [Is] ISSN: 1678-7765 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) complexes are anticariogenic and capable of remineralizing the early stages of enamel lesions. The use of fluoride prevents dental decay and the association of CPP-ACP with fluoride can increase remineralization. To evaluate the effect of CPP-ACP and CPP-ACPF creams associated with a fluoride dentifrice to prevent enamel demineralization in a pH cyclic model. MATERIAL AND METHODS: Previously selected by surface microhardness (SH) analysis, human enamel blocks (n = 56) were submitted to daily treatment with dentifrice in a pH-cycling model. The enamel blocks were divided into four groups; G1: Crest™ Cavity Protection - Procter & Gamble (1,100 ppmF of NaF); G2: Crest™ +MI Paste (MP) - Recaldent™ GC Corporation Tokyo, Japan); G3: Crest™ + MI Paste Plus (MPP) - Recaldent™ 900 ppm as NaF, GC Corporation Tokyo, Japan), and G4: control, saliva. Specimens were soaked alternatively in a demineralizing solution and in artificial saliva for 5 d. The fluoride dentifrice, with proportion of 1:3 (w/w), was applied three times for 60 s after the remineralization period. The undiluted MP and MPP creams were applied for 3 m/d. After cycling, SH was re-measured and cross section microhardness measurements were taken. RESULTS: The SH values observed for the groups G3 (257±70), G1 (205±70), and G2 (208±84) differed from the G4 group (98±110) (one-way ANOVA and Tukey's post hoc test). There were no differences between the groups G1xG2, G2xG3, and G1xG3 for demineralization inhibition. The percentage of volume mineral showed that, when applied with fluoride dentifrice, MPP was the most effective in preventing enamel demineralization at 50 µ from the outer enamel surface (Kruskal-Wallis and Mann Whitney p<0.05). CONCLUSION: Fluoride dentifrice associated with CPP-ACPF inhibited subsurface enamel demineralization. [Mh] Termos MeSH primário: Cariostáticos/administração & dosagem Caseínas/administração & dosagem Esmalte Dentário/efeitos dos fármacos Dentifrícios/administração & dosagem Desmineralização do Dente/tratamento farmacológico [Mh] Termos MeSH secundário: Animais Bovinos Concentração de Íons de Hidrogênio Cremes Dentais [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cariostatic Agents); 0 (Caseins); 0 (Dentifrices); 0 (Toothpastes); 0 (casein phosphopeptide-amorphous calcium phosphate nanocomplex) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 171207 [St] Status: MEDLINE

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[PMID]: 29182464 [Au] Autor: Weatherly LM; Gosse JA [Ad] Endereço: a Graduate School of Biomedical Science and Engineering , University of Maine , Orono , ME , USA. [Ti] Título: Triclosan exposure, transformation, and human health effects. [So] Source: J Toxicol Environ Health B Crit Rev;20(8):447-469, 2017. [Is] ISSN: 1521-6950 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the US population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the US Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste, mouthwash, hand sanitizer, and surgical soaps. TCS is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids. The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes. The burgeoning literature on human health effects associated with TCS exposure, such as reproductive problems, was also summarized. [Mh] Termos MeSH primário: Anti-Infecciosos Locais/toxicidade Poluentes Ambientais/toxicidade Triclosan/toxicidade [Mh] Termos MeSH secundário: Animais Anti-Infecciosos Locais/química Anti-Infecciosos Locais/metabolismo Poluentes Ambientais/química Poluentes Ambientais/metabolismo Higienizadores de Mão Seres Humanos Antissépticos Bucais Sabões Cremes Dentais Triclosan/química Triclosan/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nome de substância: 0 (Anti-Infective Agents, Local); 0 (Environmental Pollutants); 0 (Hand Sanitizers); 0 (Mouthwashes); 0 (Soaps); 0 (Toothpastes); 4NM5039Y5X (Triclosan) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 180104 [Lr] Data última revisão: 180104 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171129 [St] Status: MEDLINE [do] DOI: 10.1080/10937404.2017.1399306

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[PMID]: 28657808 [Au] Autor: Oh HJ; Oh HW; Lee DW; Kim CH; Ahn JY; Kim Y; Shin HB; Kim CY; Park SH; Jeon JG [Ad] Endereço: 1 Graduate School of Archives and Records Management, Chonbuk National University, Jeonju, Republic of Korea. [Ti] Título: Chronologic Trends in Studies on Fluoride Mechanisms of Action. [So] Source: J Dent Res;96(12):1353-1360, 2017 Nov. [Is] ISSN: 1544-0591 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Fluoride has been widely used for the prevention of dental caries since the mid-20th century. The aim of this study was to investigate the chronologic trends in studies on fluoride mechanisms of action against dental caries during the years 1950 to 2015. To this aim, queries such as "fluoride," "fluoride and demineralization," "fluoride and remineralization," "fluoride and (plaque or biofilms)," and "fluoride and (bacteria or microbials)" were submitted to PubMed to collect research article information, including titles, abstracts, publication dates, author affiliations, and publication journals. The article information that PubMed produced was then collected by an automatic web crawler and examined through informetrics and linguistic analyses. We found that the number of articles concerned with fluoride mechanisms of action against dental caries was 6,903 and gradually increased over time during the years 1950 to 2015. They were published by 1,136 journals-most notably, Caries Research and Journal of Dental Research. Of the articles published, those related to bacteria/microbials had a higher percentage (44%) than those dealing with plaque/biofilms, demineralization, and remineralization. With regard to the geographic distribution of authors, Europe and North America accounted for 65% of the articles during the years 1987 to 2015, although the number of authors in Asia sharply increased in recent years. Among the fluoride compounds, NaF was mentioned more frequently than SnF , Na PO F, amine fluoride, and acidulated phosphate fluoride during the years 1986 to 2015. Water fluoridation received the most attention among the various fluoride application methods (toothpastes, mouthwashes, fluoride varnishes, and fluoride gels) during the same period. These results, obtained from employing informetrics and linguistic analyses, suggest that in studies on fluoride mechanisms of action, 1) the unbalanced geographic distribution of articles and 2) the heavy concentration of articles on particular fluoride compounds and application methods should be overcome in future research. [Mh] Termos MeSH primário: Cariostáticos/farmacologia Cárie Dentária/prevenção & controle Fluoretos/farmacologia [Mh] Termos MeSH secundário: Biofilmes/efeitos dos fármacos Cariostáticos/química Cárie Dentária/microbiologia Placa Dentária/tratamento farmacológico Placa Dentária/microbiologia Fluoretos/química Seres Humanos Antissépticos Bucais/química Antissépticos Bucais/farmacologia Desmineralização do Dente/prevenção & controle Remineralização Dentária/métodos Cremes Dentais/química Cremes Dentais/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Cariostatic Agents); 0 (Mouthwashes); 0 (Toothpastes); Q80VPU408O (Fluorides) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171101 [Lr] Data última revisão: 171101 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 170629 [St] Status: MEDLINE [do] DOI: 10.1177/0022034517717680

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[PMID]: 28646837 [Au] Autor: Skowron K; Jakubicz A; Budzynska A; Kaczmarek A; Grudlewska K; Reslinski A; Gospodarek-Komkowska E [Ad] Endereço: Department of Microbiology, Faculty of Pharmacy, Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland [Ti] Título: Microbiological purity assessment of cosmetics used by one and several persons and cosmetics after their expiry date [So] Source: Rocz Panstw Zakl Hig;68(2):191-197, 2017. [Is] ISSN: 0035-7715 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: Background: Microbiological purity of cosmetics provides safety of users during their use, prevents physicochemical changes of a preparation, infections and diseases of the skin. Objective: The aim of this study was to assess the level of microbiological contamination of cosmetics used by one person and by several people and cosmetics after their expiry date in relations to standards for marketed cosmetics, ensuring safety of their use. Material and Methods: This study was conducted using 55 samples representing 19 types of cosmetics, divided into three groups: used by one person, used by several people and after the expiry date. In cosmetic samples the general numbers of aerobic mesophilic bacteria were determined with the spread plate method on tryptic-soy agar. The presence of Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans were also checked. Results: The number of aerobic mesophylic bacteria in the tested cosmetics ranged from the level below the method detectability to 1.3×107 cfu/g or ml. The presence of Staphylococcus spp. was found in 11 (20.0%) tested cosmetic samples and of P. aeruginosa in one tested preparation. Yeasts C. albicans were not detected, whereas contamination with fungi Aspergillus spp. and Penicillium spp. ranging from 0.5×101 to 1.5×101 cfu/g or ml was recorded in four cosmetics. The level of microbiological contamination of cosmetics used by several people was higher than that of cosmetics used by one person. Cosmetics after the expiry date showed the highest microbiological contamination. Conclusions: The number of users of cosmetic and it expiry date exceeding influenced the level of microbial contamination of preparations. [Mh] Termos MeSH primário: Cosméticos Contaminação de Medicamentos [Mh] Termos MeSH secundário: Fungos/isolamento & purificação Seres Humanos Pseudomonas aeruginosa/isolamento & purificação Staphylococcus aureus/isolamento & purificação Cremes Dentais [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cosmetics); 0 (Toothpastes) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170626 [St] Status: MEDLINE

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[PMID]: 28540937 [Au] Autor: Pitts NB; Zero DT; Marsh PD; Ekstrand K; Weintraub JA; Ramos-Gomez F; Tagami J; Twetman S; Tsakos G; Ismail A [Ad] Endereço: Dental Innovation and Translation Centre, King's College London Dental Institute, Floor 17 Tower Wing, Guy's Hospital, Great Maze Pond Road, London SE1 9RT, UK. [Ti] Título: Dental caries. [So] Source: Nat Rev Dis Primers;3:17030, 2017 May 25. [Is] ISSN: 2056-676X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues. Caries can occur throughout life, both in primary and permanent dentitions, and can damage the tooth crown and, in later life, exposed root surfaces. The balance between pathological and protective factors influences the initiation and progression of caries. This interplay between factors underpins the classification of individuals and groups into caries risk categories, allowing an increasingly tailored approach to care. Dental caries is an unevenly distributed, preventable disease with considerable economic and quality-of-life burdens. The daily use of fluoride toothpaste is seen as the main reason for the overall decline of caries worldwide over recent decades. This Primer aims to provide a global overview of caries, acknowledging the historical era dominated by restoration of tooth decay by surgical means, but focuses on current, progressive and more holistic long-term, patient-centred, tooth-preserving preventive care. [Mh] Termos MeSH primário: Cárie Dentária/prevenção & controle Fluoretos/administração & dosagem [Mh] Termos MeSH secundário: Índice CPO Cárie Dentária/epidemiologia Placa Dentária/prevenção & controle Fluoretos/uso terapêutico Seres Humanos Remineralização Dentária Cremes Dentais/química [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Toothpastes); Q80VPU408O (Fluorides) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170526 [St] Status: MEDLINE [do] DOI: 10.1038/nrdp.2017.30

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[PMID]: 28521109 [Au] Autor: O'Neill C; Worthington HV; Donaldson M; Birch S; Noble S; Killough S; Murphy L; Greer M; Brodison J; Verghis R; Tickle M [Ad] Endereço: 1 Centre for Public Health, Queen's University Belfast, Belfast, UK. [Ti] Título: Cost-Effectiveness of Caries Prevention in Practice: A Randomized Controlled Trial. [So] Source: J Dent Res;96(8):875-880, 2017 Jul. [Is] ISSN: 1544-0591 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A 2-arm parallel-group randomized controlled trial measured the cost-effectiveness of caries prevention in caries-free children aged 2 to 3 y attending general practice. The setting was 22 dental practices in Northern Ireland. Participants were centrally randomized into intervention (22,600 ppm fluoride varnish, toothbrush, a 50-mL tube of 1,450 ppm fluoride toothpaste, and standardized prevention advice) and control (advice only), both provided at 6-monthly intervals during a 3-y follow-up. The primary outcome measure was conversion from caries-free to caries-active states assessed by calibrated and blinded examiners; secondary outcome measures included decayed, missing, or filled teeth surfaces (dmfs); pain; and extraction. Cumulative costs were related to each of the trial's outcomes in a series of incremental cost effectiveness ratios (ICERs). Sensitivity analyses examined the impact of using dentist's time as measured by observation rather than that reported by the dentist. The costs of applying topical fluoride were also estimated assuming the work was undertaken by dental nurses or hygienists rather than dentists. A total of 1,248 children (624 randomized to each group) were recruited, and 1,096 (549 in the intervention group and 547 in the control group) were included in the final analyses. The mean difference in direct health care costs between groups was £107.53 (£155.74 intervention, £48.21 control, P < 0.05) per child. When all health care costs were compared, the intervention group's mean cost was £212.56 more than the control group (£987.53 intervention, £774.97 control, P < 0.05). Statistically significant differences in outcomes were only detected with respect to carious surfaces. The mean cost per carious surface avoided was estimated at £251 (95% confidence interval, £454.39-£79.52). Sensitivity analyses did not materially affect the study's findings. This trial raises concerns about the cost-effectiveness of a fluoride-based intervention delivered at the practice level in the context of a state-funded dental service (EudraCT No: 2009-010725-39; ISRCTN: ISRCTN36180119). [Mh] Termos MeSH primário: Análise Custo-Benefício Assistência Odontológica para Crianças/economia Cárie Dentária/economia Cárie Dentária/prevenção & controle Prevenção Primária/economia [Mh] Termos MeSH secundário: Cariostáticos/uso terapêutico Pré-Escolar Feminino Fluoretos Tópicos/uso terapêutico Odontologia Geral Seres Humanos Lactente Masculino Irlanda do Norte Avaliação de Resultados (Cuidados de Saúde) Escovação Dentária Cremes Dentais [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Cariostatic Agents); 0 (Fluorides, Topical); 0 (Toothpastes) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170906 [Lr] Data última revisão: 170906 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 170519 [St] Status: MEDLINE [do] DOI: 10.1177/0022034517708968

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[PMID]: 28375708 [Au] Autor: Tickle M; O'Neill C; Donaldson M; Birch S; Noble S; Killough S; Murphy L; Greer M; Brodison J; Verghis R; Worthington HV [Ad] Endereço: 1 Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. [Ti] Título: A Randomized Controlled Trial of Caries Prevention in Dental Practice. [So] Source: J Dent Res;96(7):741-746, 2017 Jul. [Is] ISSN: 1544-0591 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: We conducted a parallel group randomized controlled trial of children initially aged 2 to 3 y who were caries free, to prevent the children becoming caries active over the subsequent 36 mo. The setting was 22 dental practices in Northern Ireland, and children were randomly assigned by a clinical trials unit (CTU) (using computer-generated random numbers, with allocation concealed from the dental practice until each child was recruited) to the intervention (22,600-ppm fluoride varnish, toothbrush, 50-mL tube of 1,450 ppm fluoride toothpaste, and standardized, evidence-based prevention advice) or advice-only control at 6-monthly intervals. The primary outcome measure was conversion from caries-free to caries-active states. Secondary outcome measures were number of decayed, missing, or filled teeth (dmfs) in caries-active children, number of episodes of pain, and number of extracted teeth. Adverse reactions were recorded. Calibrated external examiners, blinded to the child's study group, assessed the status of the children at baseline and after 3 y. In total, 1,248 children (624 randomized to each group) were recruited, and 1,096 (549 intervention, 547 control) were included in the final analyses. Eighty-seven percent of intervention and 86% of control children attended every 6-mo visit ( P = 0.77). A total of 187 (34%) in the intervention group converted to caries active compared to 213 (39%) in the control group (odds ratio, 0.81; 95% confidence interval, 0.64-1.04; P = 0.11). Mean dmfs of those with caries in the intervention group was 7.2 compared to 9.6 in the control group ( P = 0.007). There was no significant difference in the number of episodes of pain between groups ( P = 0.81) or in the number of teeth extracted in caries-active children ( P = 0.95). Ten children in the intervention group had adverse reactions of a minor nature. This well-conducted trial failed to demonstrate that the intervention kept children caries free, but there was evidence that once children get caries, it slowed down its progression (EudraCT No: 2009-010725-39; ISRCTN: ISRCTN36180119). [Mh] Termos MeSH primário: Cariostáticos/uso terapêutico Assistência Odontológica para Crianças Cárie Dentária/prevenção & controle Fluoretos Tópicos/uso terapêutico Cremes Dentais/uso terapêutico [Mh] Termos MeSH secundário: Pré-Escolar Pesquisa Comparativa da Efetividade Índice CPO Progressão da Doença Feminino Seres Humanos Lactente Masculino Irlanda do Norte Medição da Dor Escovação Dentária Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Cariostatic Agents); 0 (Fluorides, Topical); 0 (Toothpastes) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170828 [Lr] Data última revisão: 170828 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 170405 [St] Status: MEDLINE [do] DOI: 10.1177/0022034517702330

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[PMID]: 28367912 [Au] Autor: Iijima M; Kawaguchi K; Kawamura N; Ito S; Saito T; Mizoguchi I [Ad] Endereço: Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido. [Ti] Título: The effects of single application of pastes containing ion-releasing particles on enamel demineralization. [So] Source: Dent Mater J;36(4):461-468, 2017 Jul 26. [Is] ISSN: 1881-1361 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: We investigated single application of pastes containing a surface reaction-type pre-reacted glass-ionomer (S-PRG) filler on enamel demineralization. Human enamel blocks were polished using pastes containing S-PRG filler (0, 5, and 30%) and immersed in demineralizing solution for 5 days with daily change of solutions. The pH measurement and nanoindentation testing was carried out during the immersion period, and the enamel surfaces were examined using scanning electron microscopy and atomic force microscopy. A non-fluoride paste and a hydroxyapatite-containing paste were used for comparison. The specimens polished with the S-PRG filler-containing paste exhibited acid-neutralizing properties, which became stronger with an increasing S-PRG filler content. Following immersion in the demineralizing solution, specimens polished with the S-PRG filler-containing paste exhibited significantly greater hardness and elastic modulus values than those polished with the other pastes and exhibited a smoother surface than did the other specimens. Pastes containing S-PRG filler inhibits the demineralization of enamel. [Mh] Termos MeSH primário: Esmalte Dentário Desmineralização do Dente [Mh] Termos MeSH secundário: Dureza Seres Humanos Microscopia Eletrônica de Varredura Pomadas Cremes Dentais [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ointments); 0 (Toothpastes) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170823 [Lr] Data última revisão: 170823 [Sb] Subgrupo de revista: D [Da] Data de entrada para processamento: 170404 [St] Status: MEDLINE [do] DOI: 10.4012/dmj.2016-307

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[PMID]: 28367910 [Au] Autor: Nakamura K; Hamba H; Nakashima S; Sadr A; Nikaido T; Oikawa M; Uo M; Tagami J [Ad] Endereço: Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU). [Ti] Título: Effects of experimental pastes containing surface pre-reacted glass ionomer fillers on inhibition of enamel demineralization. [So] Source: Dent Mater J;36(4):482-490, 2017 Jul 26. [Is] ISSN: 1881-1361 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: This study aimed to evaluate the inhibitory effect of experimental pastes containing surface pre-reacted glass ionomer (S-PRG) fillers on enamel demineralization. Bovine blocks were treated twice a day for 4 days by 7 groups; experimental pastes containing 0-30 wt% S-PRG filler (S00, S01, S05, S10, and S30), deionized water (DW) as negative control, and NaF paste (MP) as positive control. The surfaces were demineralized by acetic acid for 3 days. Mineral loss (ML) was calculated by micro-computed X-ray tomography. The treated surface was finally investigated with scanning electron microscope (SEM) and micro-focused particle induced X-ray emission (micro-PIXE). S05, S10 and S30 demonstrated significantly lower ML than S00, S01 and DW (p<0.05). S10 showed the greatest inhibitory effect, which was significantly greater than MP. The S-PRG filler containing experimental pastes demonstrated a potential to inhibit enamel demineralization. Sr ion incorporation was confirmed on the enamel surface with the experimental pastes. [Mh] Termos MeSH primário: Esmalte Dentário Cremes Dentais [Mh] Termos MeSH secundário: Animais Bovinos Pomadas Fluoreto de Sódio [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ointments); 0 (Toothpastes); 8ZYQ1474W7 (Sodium Fluoride) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170823 [Lr] Data última revisão: 170823 [Sb] Subgrupo de revista: D [Da] Data de entrada para processamento: 170404 [St] Status: MEDLINE [do] DOI: 10.4012/dmj.2016-303

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[PMID]: 28291073 [Au] Autor: de Groot A [Ad] Endereço: From acdegroot publishing, Wapserveen, The Netherlands. [Ti] Título: Contact Allergy to (Ingredients of) Toothpastes. [So] Source: Dermatitis;28(2):95-114, 2017 Mar/Apr. [Is] ISSN: 2162-5220 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The literature on contact allergy to (ingredients of) toothpastes is critically reviewed. We have found 47 case reports, small case series (n = 2-5) and citations published between 1900 and 2016 describing more than 60 patients allergic to toothpastes, and in addition 3 larger case series and many descriptions of toothpaste allergy among selected groups of patients. Allergic reactions usually manifest as cheilitis with or without dermatitis around the mouth, less frequently by oral symptoms. Formerly, many reactions were caused by cinnamon derivatives; more recently, reported allergens are diverse. A semiopen test or closed patch test with the toothpaste "as is" may be performed as an initial test, but a positive reaction should always be followed by confirmatory tests. The role of contact allergy to toothpastes in patients with oral symptoms (stomatitis, glossitis, gingivitis, buccal mucositis, burning, soreness, and possibly burning mouth syndrome and recurrent aphthous ulcers) is unclear and should be further investigated. [Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia Doenças da Boca/etiologia Cremes Dentais/efeitos adversos [Mh] Termos MeSH secundário: Dermatite Alérgica de Contato/diagnóstico Seres Humanos Doenças da Boca/diagnóstico Testes do Emplastro Cremes Dentais/química [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Toothpastes) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170428 [Lr] Data última revisão: 170428 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170315 [St] Status: MEDLINE [do] DOI: 10.1097/DER.0000000000000255

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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