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[PMID]: | 28302110 |
[Au] Autor: | Palacios S; Losa F; Dexeus D; Cortés J |
[Ad] Endereço: | Gynecology and Obstetrics Department, Instituto Palacios de Medicina y Salud de la Mujer, C/Antonio Acuña 9, E-28009, Madrid, Spain. spalacios@institutopalacios.com. |
[Ti] Título: | Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women. |
[So] Source: | BMC Womens Health;17(1):21, 2017 Mar 16. | [Is] ISSN: | 1472-6874 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: To assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide, Coriolus versicolor, Asian centella, Azadirachta indica and Aloe vera on vaginal microbiota, cervical epithelization and vaginal health. METHODS: Open-label, prospective pilot study conducted in asymptomatic women in daily practice. Cervical epithelization was evaluated by colposcopy using an ectopy epithelization score (from 5: no ectopy to 1: severe ectopy and bleeding), vaginal microbiota using the VaginaStatus-Diagnostic test (Instiüt für Mikroökologie, Herborn, Germany) and further rated by the investigator using a 5-point Liker scale (from 5: normal to 1: very severe deterioration in which all evaluated species were altered), and vaginal health using the Vaginal Health Index. RESULTS: In 21 women, a positive effect to improve epithelization of the cervical mucosa, with a mean score of 4.42 at the final visit as compared to 3.09 at baseline (P < 0.0001) (43% improvement). In 10 women, there was a trend of improving of vaginal microbiota status, with a mean score of 4.0 at the final visit vs. 3.3 at baseline (P = NS) (21.2% improvement). In 11 women, the Vaginal Health Index increased from 19.0 at baseline to 22.3 at the final visit (P = 0.007). The concentration of Lactobacillus spp. increased 54.5% of women and pH decreased from 4.32 to 4.09. CONCLUSIONS: These encouraging preliminary results provide the basis for designing a randomized controlled study, and for potential use in human papilloma virus infection. TRIAL REGISTRATION: ISRCTN77955077 . Registration date: February 15, 2017. Retrospectively registered. |
[Mh] Termos MeSH primário: |
Vagina/microbiologia Cremes, Espumas e Géis Vaginais/farmacologia
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[Mh] Termos MeSH secundário: |
Adulto Muco do Colo Uterino/microbiologia Colposcopia/métodos Interpretação Estatística de Dados Feminino Seres Humanos Lactobacillus/crescimento & desenvolvimento Microbiota/efeitos dos fármacos Projetos Piloto Estudos Prospectivos Espanha Cremes, Espumas e Géis Vaginais/administração & dosagem Cremes, Espumas e Géis Vaginais/uso terapêutico
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Vaginal Creams, Foams, and Jellies) |
[Em] Mês de entrada: | 1708 |
[Cu] Atualização por classe: | 170815 |
[Lr] Data última revisão:
| 170815 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170318 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1186/s12905-017-0374-2 |
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