Base de dados : MEDLINE
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  1 / 26 MEDLINE  
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[PMID]:28562262
[Au] Autor:Green JL; Wang GS; Reynolds KM; Banner W; Bond GR; Kauffman RE; Palmer RB; Paul IM; Dart RC
[Ad] Endereço:Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colorado; jody.green@rmpdc.org.
[Ti] Título:Safety Profile of Cough and Cold Medication Use in Pediatrics.
[So] Source:Pediatrics;139(6), 2017 Jun.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: The safety of cough and cold medication (CCM) use in children has been questioned. We describe the safety profile of CCMs in children <12 years of age from a multisystem surveillance program. METHODS: Cases with adverse events (AEs) after ingestion of at least 1 index CCM ingredient (brompheniramine, chlorpheniramine, dextromethorphan, diphenhydramine, doxylamine, guaifenesin, phenylephrine, and pseudoephedrine) in children <12 years of age were collected from 5 data sources. An expert panel determined relatedness, dose, intent, and risk factors. Case characteristics and AEs are described. RESULTS: Of the 4202 cases reviewed, 3251 (77.4%) were determined to be at least potentially related to a CCM, with accidental unsupervised ingestions (67.1%) and medication errors (13.0%) the most common exposure types. Liquid (67.3%), pediatric (75.5%), and single-ingredient (77.5%) formulations were most commonly involved. AEs occurring in >20% of all cases included tachycardia, somnolence, hallucinations, ataxia, mydriasis, and agitation. Twenty cases (0.6%) resulted in death; most were in children <2 years of age (70.0%) and none involved a therapeutic dose. The overall reported AE rate was 0.573 cases per 1 million units (ie, tablets, gelatin capsules, or liquid equivalent) sold (95% confidence interval, 0.553-0.593) or 1 case per 1.75 million units. CONCLUSIONS: The rate of AEs associated with CCMs in children was low. Fatalities occurred even less frequently. No fatality involved a therapeutic dose. Accidental unsupervised ingestions were the most common exposure types and single-ingredient, pediatric liquid formulations were the most commonly reported products. These characteristics present an opportunity for targeted prevention efforts.
[Mh] Termos MeSH primário: Antitussígenos/efeitos adversos
Tosse/tratamento farmacológico
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Medicamentos Compostos contra Resfriado, Influenza e Alergia/efeitos adversos
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Pediatria
Fatores de Risco
Segurança
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitussive Agents); 0 (Multi-Ingredient Cold, Flu, and Allergy Medications)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE


  2 / 26 MEDLINE  
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[PMID]:28278336
[Au] Autor:Wakamatsu TH; Ueta M; Tokunaga K; Okada Y; Loureiro RR; Costa KA; Sallum JMF; Milhomens JA; Inoue C; Sotozono C; Gomes JÁP; Kinoshita S
[Ad] Endereço:Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
[Ti] Título:Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population.
[So] Source:JAMA Ophthalmol;135(4):355-360, 2017 Apr 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Describing the association with human leukocyte antigen (HLA) alleles could facilitate the understanding of increased risk factors for development of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients with severe ocular complications (SOCs). Objective: To investigate the association between HLA class I genes and cold medicine (CM)-associated SJS/TEN with SOCs. Design, Setting, and Participants: This case-control study was conducted between February 8, 2013, and August 29, 2014. Thirty-nine Brazilian patients with CM-SJS/TEN of 74 patients with SJS/TEN with SOCs and 133 healthy Brazilian volunteers were enrolled. Human leukocyte antigen class I genes (HLA-A, HLA-B, and HLA-C) were examined to determine whether there was a genetic predisposition for CM-SJS/TEN with SOC. Patients were interviewed to identify possible etiologic factors. Data analysis was performed from April 14, 2013, to August 29, 2014. Main Outcomes and Measures: Genetic predisposition for CM-SJS/TEN with SOCs by analysis of HLA class I genes. Results: Of 74 patients included in the analysis, 32 (43%) were male; mean (SD) age was 36.01 [15.42] years. HLA-A*66:01 (odds ratio [OR], 24.0; 95% CI, 2.79-206.0; P < .001), HLA-B*44:03 (OR, 2.71; 95% CI, 1.11-6.65; P = .04), and HLA-C*12:03 (OR, 5.6; 95% CI, 1.67-18.80; P = .006) were associated with Brazilian CM-SJS/TEN with SOCs, and HLA-A*11:01 (OR, 0.074; 95% CI, 0.004-1.26; P = .008), HLA-B*08:01 (OR, 0.15; 95% CI, 0.02-1.15; P = .048), and HLA-B*51:01 (OR, 0.23; 95% CI, 0.05-1.03; P = .045) were inversely associated with Brazilian CM-SJS/TEN with SOCs (39 cases: 19 Pardo and 16 European ancestry; 14 males and 25 females; age, 35.2 [14.4] years; and 133 controls: 66 Pardo and 61 European ancestry; 55 males and 78 females; age, 41.2 [12.9] years). When multiple test correction within the HLA locus, HLA-A*66:01 and HLA-C*12:03 demonstrated associations. When participants were segregated into Pardo and locus is considered, HLA-A*66:01 was associated with CM-SJS/TEN with SOC among individuals of both ethnic groups (Pardo: OR, 12.2; 95% CI, 1.19-125.0; P = .03; and European: OR, 21.2; 95% CI, 0.97-465.0; P = .04). An association was observed only in the European cohort for HLA-B*44:03 (OR, 5.50; 95% CI, 1.47-20.50; P = .01) and HLA-C*12:03 (OR, 8.79; 95% CI, 1.83-42.20; P = .008). Conclusions and Relevance: This study suggests that HLA-A*66:01 might be a marker for CM-SJS/TEN with SOCs in Brazilian individuals of Pardo and European ancestry and that HLA-B*44:03 and HLA-C*12:03 might be markers only in those of European ancestry. Moreover, HLA-A*11:01 might be a marker of resistance to CM-SJS/TEN with SOCs.
[Mh] Termos MeSH primário: Síndromes do Olho Seco/genética
Antígenos HLA-A/genética
Antígenos HLA-B/genética
Antígenos HLA-C/genética
Medicamentos Compostos contra Resfriado, Influenza e Alergia/efeitos adversos
Síndrome de Stevens-Johnson/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Alelos
Brasil
Estudos de Casos e Controles
Criança
Síndromes do Olho Seco/induzido quimicamente
Feminino
Marcadores Genéticos
Técnicas de Genotipagem
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Síndrome de Stevens-Johnson/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers); 0 (HLA-A Antigens); 0 (HLA-B Antigens); 0 (HLA-C Antigens); 0 (Multi-Ingredient Cold, Flu, and Allergy Medications)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170624
[Lr] Data última revisão:
170624
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.0074


  3 / 26 MEDLINE  
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[PMID]:28100913
[Au] Autor:Ueta M; Sawai H; Shingaki R; Kawai Y; Sotozono C; Kojima K; Yoon KC; Kim MK; Seo KY; Joo CK; Nagasaki M; Kinoshita S; Tokunaga K
[Ad] Endereço:Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
[Ti] Título:Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications.
[So] Source:J Hum Genet;62(4):485-489, 2017 Apr.
[Is] ISSN:1435-232X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16. This study might suggest the usefulness of GWAS using the ethnicity-specific array and genome-wide imputation based on large-scale whole-genome sequences. Our findings contribute to the understanding of genetic predisposition to CM-SJS with SOC.
[Mh] Termos MeSH primário: Oftalmopatias/genética
Antígeno HLA-A2/genética
Recombinases/genética
Síndrome de Stevens-Johnson/genética
Receptor 3 Toll-Like/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Grupo com Ancestrais do Continente Asiático
Criança
Grupos Étnicos
Oftalmopatias/induzido quimicamente
Oftalmopatias/patologia
Feminino
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Genótipo
Seres Humanos
Japão
Masculino
Meia-Idade
Medicamentos Compostos contra Resfriado, Influenza e Alergia/efeitos adversos
Polimorfismo de Nucleotídeo Único
Síndrome de Stevens-Johnson/complicações
Síndrome de Stevens-Johnson/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HLA-A*02:06 antigen); 0 (HLA-A2 Antigen); 0 (Multi-Ingredient Cold, Flu, and Allergy Medications); 0 (REC114 protein, human); 0 (Recombinases); 0 (TLR3 protein, human); 0 (Toll-Like Receptor 3)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1038/jhg.2016.160


  4 / 26 MEDLINE  
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[PMID]:26457856
[Au] Autor:Newton ER; Hale TW
[Ad] Endereço:*Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina †Department of Pediatrics, School of Medicine, Texas Tech University, Lubbock, Texas.
[Ti] Título:Drugs in Breast Milk.
[So] Source:Clin Obstet Gynecol;58(4):868-84, 2015 Dec.
[Is] ISSN:1532-5520
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most drugs appear in breast milk in very small and safe amounts. The obstetric care provider evaluates drug transfer most commonly in the peripartum period, postpartum hospitalization; and they are often consulted when the new mother has a subsequent need for drug therapy. The chapter provides the foundations for the safest decisions for the mother and her breastfed infant. The foundation of safe decisions is accomplished through a review of the physiology of lactation, the lactation pharmacology, and the specific pharmacology and infant safety of drugs common to everyday obstetric practice.
[Mh] Termos MeSH primário: Aleitamento Materno
Lactação/fisiologia
Leite Humano/química
[Mh] Termos MeSH secundário: Analgésicos/farmacologia
Antibacterianos/farmacologia
Anticoagulantes/farmacologia
Anticonvulsivantes/farmacologia
Antidepressivos/farmacologia
Anti-Hipertensivos/farmacologia
Antipsicóticos/farmacologia
Aleitamento Materno/efeitos adversos
Feminino
Seres Humanos
Hipoglicemiantes/farmacologia
Recém-Nascido
Medicamentos Compostos contra Resfriado, Influenza e Alergia/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Bacterial Agents); 0 (Anticoagulants); 0 (Anticonvulsants); 0 (Antidepressive Agents); 0 (Antihypertensive Agents); 0 (Antipsychotic Agents); 0 (Hypoglycemic Agents); 0 (Multi-Ingredient Cold, Flu, and Allergy Medications)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151030
[Lr] Data última revisão:
151030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151013
[St] Status:MEDLINE
[do] DOI:10.1097/GRF.0000000000000142


  5 / 26 MEDLINE  
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[PMID]:26310854
[Au] Autor:Ito K; Weinberger KR; Robinson GS; Sheffield PE; Lall R; Mathes R; Ross Z; Kinney PL; Matte TD
[Ad] Endereço:New York City Department of Health and Mental Hygiene, Bureau of Environmental Surveillance and Policy, New York, NY, 10013, USA. kito1@health.nyc.gov.
[Ti] Título:The associations between daily spring pollen counts, over-the-counter allergy medication sales, and asthma syndrome emergency department visits in New York City, 2002-2012.
[So] Source:Environ Health;14:71, 2015 Aug 27.
[Is] ISSN:1476-069X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Many types of tree pollen trigger seasonal allergic illness, but their population-level impacts on allergy and asthma morbidity are not well established, likely due to the paucity of long records of daily pollen data that allow analysis of multi-day effects. Our objective in this study was therefore to determine the impacts of individual spring tree pollen types on over-the-counter allergy medication sales and asthma emergency department (ED) visits. METHODS: Nine clinically-relevant spring tree pollen genera (elm, poplar, maple, birch, beech, ash, sycamore/London planetree, oak, and hickory) measured in Armonk, NY, were analyzed for their associations with over-the-counter allergy medication sales and daily asthma syndrome ED visits from patients' chief complaints or diagnosis codes in New York City during March 1st through June 10th, 2002-2012. Multi-day impacts of pollen on the outcomes (0-3 days and 0-7 days for the medication sales and ED visits, respectively) were estimated using a distributed lag Poisson time-series model adjusting for temporal trends, day-of-week, weather, and air pollution. For asthma syndrome ED visits, age groups were also analyzed. Year-to-year variation in the average peak dates and the 10th-to-90th percentile duration between pollen and the outcomes were also examined with Spearman's rank correlation. RESULTS: Mid-spring pollen types (maple, birch, beech, ash, oak, and sycamore/London planetree) showed the strongest significant associations with both outcomes, with cumulative rate ratios up to 2.0 per 0-to-98th percentile pollen increase (e.g., 1.9 [95% CI: 1.7, 2.1] and 1.7 [95% CI: 1.5, 1.9] for the medication sales and ED visits, respectively, for ash). Lagged associations were longer for asthma syndrome ED visits than for the medication sales. Associations were strongest in children (ages 5-17; e.g., a cumulative rate ratio of 2.6 [95% CI: 2.1, 3.1] per 0-to-98th percentile increase in ash). The average peak dates and durations of some of these mid-spring pollen types were also associated with those of the outcomes. CONCLUSIONS: Tree pollen peaking in mid-spring exhibit substantive impacts on allergy, and asthma exacerbations, particularly in children. Given the narrow time window of these pollen peak occurrences, public health and clinical approaches to anticipate and reduce allergy/asthma exacerbation should be developed.
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Asma/epidemiologia
Hipersensibilidade/epidemiologia
Medicamentos Compostos contra Resfriado, Influenza e Alergia/economia
Pólen/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Asma/etiologia
Criança
Pré-Escolar
Serviço Hospitalar de Emergência/estatística & dados numéricos
Serviço Hospitalar de Emergência/utilização
Feminino
Seres Humanos
Hipersensibilidade/etiologia
Lactente
Recém-Nascido
Masculino
Meia-Idade
Cidade de Nova Iorque/epidemiologia
Medicamentos sem Prescrição/economia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Allergens); 0 (Multi-Ingredient Cold, Flu, and Allergy Medications); 0 (Nonprescription Drugs)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150828
[St] Status:MEDLINE
[do] DOI:10.1186/s12940-015-0057-0


  6 / 26 MEDLINE  
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[PMID]:25993915
[Au] Autor:Driedger GE; Dong KA; Newton AS; Rosychuk RJ; Ali S
[Ad] Endereço:*Department of Pediatrics,University of Alberta,Edmonton,AB.
[Ti] Título:What are kids getting into these days? A retrospective chart review of substance use presentations to a Canadian pediatric emergency department.
[So] Source:CJEM;17(4):345-52, 2015 Jul.
[Is] ISSN:1481-8035
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Goals for this study were to characterize the substances being used by youth who presented to an emergency department (ED), their demographic descriptors, and to describe the associated acute morbidity and mortality. METHODS: We conducted a retrospective review of all youth, ages 10-16 years, who presented to a pediatric ED with complaints related to recreational drug use (n=641) for 2 years ending on December 31, 2009. RESULTS: The median age of patients was 15 years; 56% were female. Six percent of patients were homeless, and 21% were wards of the state. The most frequent ingestions included ethanol (74%), marijuana (20%), ecstasy (19%), and medications (15%). Over one third of patients had ingested two or more substances. Ninety percent of patients were brought to the ED by the emergency medical services; 63% of these activations were by non-acquaintances. Of the 47% of youth who presented with a decreased level of consciousness, half had a Glasgow Coma Scale less than 13. The Canadian Triage and Acuity Scale score was 1 or 2 for 44% of patients. Sixty-eight percent received IV fluids, 42% received medication, and 4% were intubated. The admission rate was 9%. CONCLUSIONS: Youth who presented to the ED for substance use represented a socially vulnerable population whose use of recreational substances resulted in high medical acuity and significant morbidity. Improved clinical identification of such high-risk youth and subsequent design of interventions to address problematic substance use and social issues are urgently needed to complement the acute medical care that youth receive.
[Mh] Termos MeSH primário: Serviço Hospitalar de Emergência/normas
Hospitais Urbanos/estatística & dados numéricos
Medicamentos Compostos contra Resfriado, Influenza e Alergia/envenenamento
Admissão do Paciente/tendências
Medição de Risco/métodos
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Alberta/epidemiologia
Criança
Feminino
Seguimentos
Seres Humanos
Incidência
Masculino
Estudos Retrospectivos
Fatores de Risco
Distribuição por Sexo
Taxa de Sobrevida/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Multi-Ingredient Cold, Flu, and Allergy Medications)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150522
[St] Status:MEDLINE
[do] DOI:10.1017/cem.2015.13


  7 / 26 MEDLINE  
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[PMID]:25672763
[Au] Autor:Ueta M; Sawai H; Sotozono C; Hitomi Y; Kaniwa N; Kim MK; Seo KY; Yoon KC; Joo CK; Kannabiran C; Wakamatsu TH; Sangwan V; Rathi V; Basu S; Ozeki T; Mushiroda T; Sugiyama E; Maekawa K; Nakamura R; Aihara M; Matsunaga K; Sekine A; Gomes JÁ; Hamuro J; Saito Y; Kubo M; Kinoshita S; Tokunaga K
[Ad] Endereço:Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; Research Center for Inflammation and Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan; Department of Human Genetics, Graduate School of Medicine, University of Tokyo, To
[Ti] Título:IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement.
[So] Source:J Allergy Clin Immunol;135(6):1538-45.e17, 2015 Jun.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stevens-Johnson syndrome (SJS) and its severe form, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface, oral cavity, and genitals. These reactions are very rare but are often associated with inciting drugs, infectious agents, or both. OBJECTIVE: We sought to identify susceptibility loci for cold medicine-related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement (SMI). METHODS: A genome-wide association study was performed in 808 Japanese subjects (117 patients with CM-SJS/TEN with SMI and 691 healthy control subjects), and subsequent replication studies were performed in 204 other Japanese subjects (16 cases and 188 control subjects), 117 Korean subjects (27 cases and 90 control subjects), 76 Indian subjects (20 cases and 56 control subjects), and 174 Brazilian subjects (39 cases and 135 control subjects). RESULTS: In addition to the most significant susceptibility region, HLA-A, we identified IKZF1, which encodes Ikaros, as a novel susceptibility gene (meta-analysis, rs4917014 [G vs. T]; odds ratio, 0.5; P = 8.5 × 10(-11)). Furthermore, quantitative ratios of the IKZF1 alternative splicing isoforms Ik1 and Ik2 were significantly associated with rs4917014 genotypes. CONCLUSION: We identified IKZF1 as a susceptibility gene for CM-SJS/TEN with SMI not only in Japanese subjects but also in Korean and Indian subjects and showed that the Ik2/Ik1 ratio might be influenced by IKZF1 single nucleotide polymorphisms, which were significantly associated with susceptibility to CM-SJS/TEN with SMI.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/efeitos adversos
Antígenos HLA-A/genética
Fator de Transcrição Ikaros/genética
Mucosa Bucal/efeitos dos fármacos
Medicamentos Compostos contra Resfriado, Influenza e Alergia/efeitos adversos
Síndrome de Stevens-Johnson/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Processamento Alternativo
Grupo com Ancestrais do Continente Asiático
Estudos de Casos e Controles
Grupo com Ancestrais do Continente Europeu
Feminino
Loci Gênicos
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Antígenos HLA-A/imunologia
Seres Humanos
Fator de Transcrição Ikaros/imunologia
Masculino
Meia-Idade
Mucosa Bucal/patologia
Razão de Chances
Polimorfismo de Nucleotídeo Único
Isoformas de Proteínas/genética
Isoformas de Proteínas/imunologia
Síndrome de Stevens-Johnson/etnologia
Síndrome de Stevens-Johnson/etiologia
Síndrome de Stevens-Johnson/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (HLA-A Antigens); 0 (IKZF1 protein, human); 0 (Multi-Ingredient Cold, Flu, and Allergy Medications); 0 (Protein Isoforms); 148971-36-2 (Ikaros Transcription Factor)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150608
[Lr] Data última revisão:
150608
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150213
[St] Status:MEDLINE


  8 / 26 MEDLINE  
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[PMID]:25099678
[Au] Autor:Ueta M; Kannabiran C; Wakamatsu TH; Kim MK; Yoon KC; Seo KY; Joo CK; Sangwan V; Rathi V; Basu S; Shamaila A; Lee HS; Yoon S; Sotozono C; Gomes JÁ; Tokunaga K; Kinoshita S
[Ad] Endereço:1] Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan [2] Research Center for Inflammation and Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
[Ti] Título:Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications.
[So] Source:Sci Rep;4:5981, 2014 Aug 07.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.
[Mh] Termos MeSH primário: Síndromes do Olho Seco/genética
Antígeno HLA-A2/genética
Antígeno HLA-B44/genética
Síndrome de Stevens-Johnson/genética
Triquíase/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alelos
Anti-Inflamatórios não Esteroides/efeitos adversos
Brasil
Criança
Síndromes do Olho Seco/etnologia
Síndromes do Olho Seco/etiologia
Síndromes do Olho Seco/imunologia
Epitélio Anterior/imunologia
Epitélio Anterior/patologia
Grupos Étnicos
Feminino
Frequência do Gene
Antígeno HLA-A2/imunologia
Antígeno HLA-B44/imunologia
Seres Humanos
Índia
Masculino
Meia-Idade
Medicamentos Compostos contra Resfriado, Influenza e Alergia/efeitos adversos
República da Coreia
Epitélio Pigmentado da Retina/imunologia
Epitélio Pigmentado da Retina/patologia
Fatores de Risco
Síndrome de Stevens-Johnson/etnologia
Síndrome de Stevens-Johnson/etiologia
Síndrome de Stevens-Johnson/imunologia
Triquíase/etnologia
Triquíase/etiologia
Triquíase/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (HLA-A*02:06 antigen); 0 (HLA-A2 Antigen); 0 (HLA-B*44:03 antigen); 0 (HLA-B44 Antigen); 0 (Multi-Ingredient Cold, Flu, and Allergy Medications)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:140807
[Lr] Data última revisão:
140807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140808
[St] Status:MEDLINE
[do] DOI:10.1038/srep05981


  9 / 26 MEDLINE  
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[PMID]:25029722
[Ti] Título:Beware of possible risks from cold and flu remedies.
[So] Source:Harv Heart Lett;24(10):8, 2014 Jun.
[Is] ISSN:1051-5313
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Medicamentos Compostos contra Resfriado, Influenza e Alergia/efeitos adversos
Fenilefrina/efeitos adversos
[Mh] Termos MeSH secundário: Acetaminofen/efeitos adversos
Seres Humanos
Medicamentos sem Prescrição/efeitos adversos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Multi-Ingredient Cold, Flu, and Allergy Medications); 0 (Nonprescription Drugs); 1WS297W6MV (Phenylephrine); 362O9ITL9D (Acetaminophen)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140716
[Lr] Data última revisão:
140716
[Sb] Subgrupo de revista:K
[Da] Data de entrada para processamento:140718
[St] Status:MEDLINE


  10 / 26 MEDLINE  
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Texto completo
[PMID]:24198312
[Au] Autor:Yang M; So TY
[Ad] Endereço:1University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[Ti] Título:Revisiting the safety of over-the-counter cough and cold medications in the pediatric population.
[So] Source:Clin Pediatr (Phila);53(4):326-30, 2014 Apr.
[Is] ISSN:1938-2707
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Increased reports of serious adverse events in young children have led to numerous investigations of its therapeutic role in the pediatric population. A review of the literature has shown limited support of its use in young children, with the majority of randomized controlled trials showing no difference in endpoints when compared to placebo. Because of the recent recommended changes to pediatric cough and cold medication use, studies have suggested a decline in ingestion misuses, health care referrals, and reports of adverse events. While these patterns of use are reassuring, clinicians should continue to educate and provide caregivers guidance in managing cough and cold symptoms. Although a tremendous improvement in frequency of therapeutic error ingestions in children younger than 2 years was shown in these studies, the same magnitude of improvement was not seen in children 2 to 12 years. Therefore, future research is necessary to investigate its role in children younger than 12 years.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/induzido quimicamente
Doenças do Sistema Nervoso Central/induzido quimicamente
Resfriado Comum/tratamento farmacológico
Tosse/tratamento farmacológico
Medicamentos Compostos contra Resfriado, Influenza e Alergia/efeitos adversos
Medicamentos sem Prescrição/efeitos adversos
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Seres Humanos
Lactente
Pediatria/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Multi-Ingredient Cold, Flu, and Allergy Medications); 0 (Nonprescription Drugs)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140306
[Lr] Data última revisão:
140306
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:131108
[St] Status:MEDLINE
[do] DOI:10.1177/0009922813507998



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