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[PMID]:29192424
[Au] Autor:Heras-Mosteiro J; Monge-Maillo B; Pinart M; Lopez Pereira P; Reveiz L; Garcia-Carrasco E; Campuzano Cuadrado P; Royuela A; Mendez Roman I; López-Vélez R
[Ad] Endereço:Department of Preventive Medicine and Public Health & Immunology and Microbiology, Rey Juan Carlos University, Avda. Atenas s/n, Alcorcón, Madrid, Spain, 28922.
[Ti] Título:Interventions for Old World cutaneous leishmaniasis.
[So] Source:Cochrane Database Syst Rev;12:CD005067, 2017 12 01.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments. This is an update of a Cochrane Review first published in 2008. OBJECTIVES: To assess the effects of therapeutic interventions for the localised form of Old World cutaneous leishmaniasis. SEARCH METHODS: We updated our searches of the following databases to November 2016: the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, and LILACS. We also searched five trials registers and checked the reference lists of included studies for further references to relevant randomised controlled trials (RCTs). We wrote to national programme managers, general co-ordinators, directors, clinicians, WHO-EMRO regional officers of endemic countries, pharmaceutical companies, tropical medicine centres, and authors of relevant papers for further information about relevant unpublished and ongoing trials. We undertook a separate search for adverse effects of interventions for Old World cutaneous leishmaniasis in September 2015 using MEDLINE. SELECTION CRITERIA: Randomised controlled trials of either single or combination treatments in immunocompetent people with OWCL confirmed by smear, histology, culture, or polymerase chain reaction. The comparators were either no treatment, placebo/vehicle, and/or another active compound. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trials for inclusion and risk of bias and extracted data. We only synthesised data when we were able to identify at least two studies investigating similar treatments and reporting data amenable to pooling. We also recorded data about adverse effects from the corresponding search. MAIN RESULTS: We included 89 studies (of which 40 were new to this update) in 10,583 people with OWCL. The studies included were conducted mainly in the Far or Middle East at regional hospitals, local healthcare clinics, and skin disease research centres. Women accounted for 41.5% of the participants (range: 23% to 80%). The overall mean age of participants was 25 years (range 12 to 56). Most studies lasted between two to six months, with the longest lasting two years; average duration was four months. Most studies were at unclear or high risk for most bias domains. A lack of blinding and reporting bias were present in almost 40% of studies. Two trials were at low risk of bias for all domains. Trials reported the causative species poorly.Here we provide results for the two main comparisons identified: itraconazole (200 mg for six to eight weeks) versus placebo; and paromomycin ointment (15% plus 10% urea, twice daily for 14 days) versus vehicle.In the comparison of oral itraconazole versus placebo, at 2.5 months' follow up, 85/125 participants in the itraconazole group achieved complete cure compared to 54/119 in the placebo group (RR 3.70, 95% CI 0.35 to 38.99; 3 studies; 244 participants). In one study, microbiological or histopathological cure of skin lesions only occurred in the itraconazole group after a mean follow-up of 2.5 months (RR 17.00, 95% CI 0.47 to 612.21; 20 participants). However, although the analyses favour oral itraconazole for these outcomes, we cannot be confident in the results due to the very low certainty evidence. More side effects of mild abdominal pain and nausea (RR 2.36, 95% CI 0.74 to 7.47; 3 studies; 204 participants) and mild abnormal liver function (RR 3.08, 95% CI 0.53 to 17.98; 3 studies; 84 participants) occurred in the itraconazole group (as well as reports of headaches and dizziness), compared with the placebo group, but again we rated the certainty of evidence as very low so are unsure of the results.When comparing paromomycin with vehicle, there was no difference in the number of participants who achieved complete cure (RR of 1.00, 95% CI 0.86, 1.17; 383 participants, 2 studies) and microbiological or histopathological cure of skin lesions after a mean follow-up of 2.5 months (RR 1.03, CI 0.88 to 1.20; 383 participants, 2 studies), but the paromomycin group had more skin/local reactions (such as inflammation, vesiculation, pain, redness, or itch) (RR 1.42, 95% CI 0.67 to 3.01; 4 studies; 713 participants). For all of these outcomes, the certainty of evidence was very low, meaning we are unsure about these results.Trial authors did not report the percentage of lesions cured after the end of treatment or speed of healing for either of these key comparisons. AUTHORS' CONCLUSIONS: There was very low-certainty evidence to support the effectiveness of itraconazole and paromomycin ointment for OWCL in terms of cure (i.e. microbiological or histopathological cure and percentage of participants completely cured). Both of these interventions incited more adverse effects, which were mild in nature, than their comparisons, but we could draw no conclusions regarding safety due to the very low certainty of the evidence for this outcome.We downgraded the key outcomes in these two comparisons due to high risk of bias, inconsistency between the results, and imprecision. There is a need for large, well-designed international studies that evaluate long-term effects of current therapies and enable a reliable conclusion about treatments. Future trials should specify the species of leishmaniasis; trials on types caused by Leishmania infantum, L aethiopica, andL donovani are lacking. Research into the effects of treating women of childbearing age, children, people with comorbid conditions, and those who are immunocompromised would also be helpful.It was difficult to evaluate the overall efficacy of any of the numerous treatments due to the variable treatment regimens examined and because RCTs evaluated different Leishmania species and took place in different geographical areas. Some outcomes we looked for but did not find were degree of functional and aesthetic impairment, change in ability to detect Leishmania, quality of life, and emergence of resistance. There were only limited data on prevention of scarring.
[Mh] Termos MeSH primário: Antiprotozoários/uso terapêutico
Itraconazol/uso terapêutico
Leishmaniose Cutânea/terapia
Paromomicina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Animais
Anti-Infecciosos/uso terapêutico
Antiprotozoários/administração & dosagem
Terapias Complementares/métodos
Crioterapia/métodos
Extremo Oriente
Feminino
Temperatura Alta/uso terapêutico
Seres Humanos
Itraconazol/administração & dosagem
Terapia a Laser
Leishmania major
Leishmania tropica
Masculino
Meia-Idade
Oriente Médio
Bases para Pomadas/administração & dosagem
Paromomicina/administração & dosagem
Fotoquimioterapia
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antiprotozoal Agents); 0 (Ointment Bases); 304NUG5GF4 (Itraconazole); 61JJC8N5ZK (Paromomycin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD005067.pub5


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[PMID]:28566581
[Au] Autor:Manabe H; Nozawa A; Matsumoto M; Ohtani M
[Ad] Endereço:Division of Hospital Pharmacy, Tokyo Postal Services Agency Hospital.
[Ti] Título:Evaluation of Moisturizing Effect of Heparinoid Ointment (Hirudoid Soft Ointment) Diluted by White Petrolatum (Propeto).
[So] Source:Yakugaku Zasshi;137(6):763-766, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Steroid ointments are frequently mixed with moisturizer. It was reported that steroid ointments mixed with moisturizer increase permeability. There are only few studies done on the permeability of the moisturizer. We researched moisturizing effect of heparinoid ointment (Hirudoid Soft ointment) diluted with white petrolatum (Propeto) on the dry skin models by measuring water content of stratum. Two to four fold dilution of Hirudoid to white petrolatum resulted in a significant decrease in the moisturizing effect of the active ingredient. There was no significant difference in moisturizing effect between four times diluted mixture and white petrolatum alone. This leads to the conclusion that steroid ointment mixture with moisturizer is frequently used, but we should take more caution regarding the decrease of moisturizing effect.
[Mh] Termos MeSH primário: Água Corporal/metabolismo
Heparinoides/química
Heparinoides/farmacologia
Bases para Pomadas
Vaselina/química
Vaselina/farmacologia
Pele/metabolismo
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Condutividade Elétrica
Feminino
Heparinoides/administração & dosagem
Seres Humanos
Masculino
Pomadas
Vaselina/administração & dosagem
Fenômenos Fisiológicos da Pele
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heparinoids); 0 (Ointment Bases); 0 (Ointments); 8009-03-8 (Petrolatum)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00191


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[PMID]:28381726
[Au] Autor:Taguchi M; Shigeyama M; Ito N; Ogawa N; Takahashi C; Murata M; Hanioka N; Yamamoto H; Teramachi H
[Ad] Endereço:Center for Clinical Pharmacy, Yokohama University of Pharmacy.
[Ti] Título:Preparation and Evaluation of Modified Mohs Paste without Starch.
[So] Source:Yakugaku Zasshi;137(4):477-484, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Mohs paste is an external preparation containing zinc hydrochloride and zinc oxide starch as the main ingredient, and it is used for the palliative treatment of patients with surgically untreatable malignant tumors. However, it has problems, such as changes in hardness and viscoelasticity with time and liquefaction by exudate. To overcome these problems, we modified the formulation of Mohs paste by excluding starch, which is the cause of physical changes, and investigated the base. In the modified Mohs paste using the macrogol ointment for the base, no marked change with time was noted in the hardness, malleability, or elongation property, and the water-absorbing properties were equivalent to those of Mohs paste immediately after preparation. The hardness did not decrease even after absorbing water. The drug release rate increased 1.5 times with the modified Mohs paste. Based on these findings, the risk of liquefaction-associated damage of the surrounding skin decreased on using the modified Mohs paste, and preparing in advance became possible. These results suggest that the modified Mohs paste using the macrogol ointment for the base exhibits an equivalent effect for control of exudate and a high effect for tissue fixation.
[Mh] Termos MeSH primário: Cloretos
Composição de Medicamentos/métodos
Compostos de Zinco
Óxido de Zinco
[Mh] Termos MeSH secundário: Fenômenos Químicos
Bases para Pomadas
Pomadas
Polietilenoglicóis
Amido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Ointment Bases); 0 (Ointments); 0 (Zinc Compounds); 30IQX730WE (Polyethylene Glycols); 86Q357L16B (zinc chloride); 9005-25-8 (Starch); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00248


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[PMID]:28274658
[Au] Autor:Horita K; Horita D; Tomita H; Yasoshima M; Yagami A; Matsunaga K
[Ad] Endereço:Research Laboratory, Ikedamohando Co., Ltd., Jinden, Kamiichi-machi, Nakaniikawa, Toyama 930-0394, Japan. Electronic address: horita.kt@ikedamohando.co.jp.
[Ti] Título:Effects of different base agents on prediction of skin irritation by sodium lauryl sulfate using patch testing and repeated application test.
[So] Source:Toxicology;382:10-15, 2017 May 01.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Animal testing for cosmetics was banned in the European Union (EU) in 2013; therefore, human tests to predict and ensure skin safety such as the patch test or usage test are now in demand in Japan as well as in the EU. In order to investigate the effects of different bases on the findings of tests to predict skin irritation, we performed patch testing (PT) and the repeated application test (RAT) using sodium lauryl sulfate (SLS), a well-known irritant, dissolved in 6 different base agents to examine the effects of these bases on skin irritation by SLS. The bases for PT were distilled water, 50% ethanol, 100% ethanol, a gel containing 50% ethanol, white petrolatum, and hydrophilic cream. The concentrations of SLS were 0.2% and 0.5%. Twelve different base combinations were applied to the normal back skin of 19 individuals for 24h. RAT was performed with distilled water, 50% ethanol, 100% ethanol, a gel containing 50% ethanol, white petrolatum, and hydrophilic cream containing SLS at concentrations of 0.2%, 2%, and 5%, being applied to the arms of the same PT subjects. The test preparation of each base was applied at the same site, with 0.2% SLS being used in the first week, 2% SLS in the following week, and 5% SLS in the final week. The results of PT revealed that skin irritation scores varied when SLS at the same concentration was dissolved in a different base. The results of RAT showed that although skin irritation appeared with every base at a concentration of 5%, the positive rate was approximately the same. In conclusion, our results suggest that skin irritation elicited in PT depends on the base, while in RAT, it does not depend on the type of base employed.
[Mh] Termos MeSH primário: Irritantes
Bases para Pomadas/química
Dodecilsulfato de Sódio
Tensoativos
[Mh] Termos MeSH secundário: Adulto
Idoso
Etanol/química
Feminino
Seres Humanos
Irritantes/química
Irritantes/toxicidade
Masculino
Meia-Idade
Vaselina/química
Testes Cutâneos
Dodecilsulfato de Sódio/química
Dodecilsulfato de Sódio/toxicidade
Solventes/química
Tensoativos/química
Tensoativos/toxicidade
Água/química
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Irritants); 0 (Ointment Bases); 0 (Solvents); 0 (Surface-Active Agents); 059QF0KO0R (Water); 368GB5141J (Sodium Dodecyl Sulfate); 3K9958V90M (Ethanol); 8009-03-8 (Petrolatum)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:27193304
[Au] Autor:Ashizuka Y; Horisawa E
[Ad] Endereço:Maruho Co., Ltd., Kyoto R&D Center Drug Discovery Research Laboratories.
[Ti] Título:Effects of Manufacturing Conditions on Pharmaceutical Properties of Petrolatum Ointment.
[So] Source:Yakugaku Zasshi;136(8):1161-9, 2016 08 01.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Oleaginous white petrolatum ointment (WP ointment) is one of the most commonly used dosage forms in the preparation of topical products. In general, WP ointments containing medium chain fatty acid triglycerides (MCT) are manufactured through a process of melting, mixing, agitating, and cooling. To investigate the pharmaceutical properties of WP ointments in greater detail, we examined manufacturing factors which could potentially influence the pharmaceutical properties of the finished product. WP ointment samples containing 10% MCT were stirred with a homogenizer and a paddle mixer at 65°C, then the homogenizer was stopped. Next, the paddle-mixer was stopped at several planned temperature points at which different samples were taken. Each sample was then cooled under the following planned conditions: rapid-cooling [-50°C/h] and slow-cooling [-7.5°C/h]. The pharmaceutical properties of each WP ointment sample, along with the appearance (Optical/digital microscope), hardness (Rheometer), and bleeding ability (100 Mesh wire-net cone) were measured. Then, release profiles were performed with a WP ointment using the model active ingredient Vitamin D. As a result, high hardness, low bleeding ability and low release profile were observed in the WP ointment samples that were manufactured under the condition of stopping the paddle-mixer at 40°C. However, the influence of cooling speed was observed to affect only hardness. Through optical microscopic observation, it was found that the appearance of WP ointment samples differed depending on the conditions under which they were manufactured. In this study, it was clear that the pharmaceutical properties of WP ointment samples were particularly influenced by the paddle-mixer stopping temperature.
[Mh] Termos MeSH primário: Bases para Pomadas/química
Vaselina/química
Tecnologia Farmacêutica/métodos
[Mh] Termos MeSH secundário: Fenômenos Químicos
Cristalização
Ácidos Graxos
Pomadas
Temperatura Ambiente
Triglicerídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Ointment Bases); 0 (Ointments); 0 (Triglycerides); 8009-03-8 (Petrolatum)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160520
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.15-00247


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[PMID]:27027785
[Au] Autor:Meinke MC; Schanzer S; Richter H; Rippke F; Filbry A; Bohnsack K; Patzelt A; Lademann J
[Ad] Endereço:Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charitx00E9; - Universitx00E4;tsmedizin Berlin, Berlin, Germany.
[Ti] Título:Prevention of Cutaneous Penetration and CD1c+ Uptake of Pollen Allergens by a Barrier-Enhancing Formulation.
[So] Source:Skin Pharmacol Physiol;29(2):71-5, 2016.
[Is] ISSN:1660-5535
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Recent studies have shown that pollen proteins can penetrate the impaired skin barrier of atopic patients and exacerbate their disease. In the presented study the effect of a topically applied barrier-enhancing formulation was investigated for its preventive effect on the uptake of pollen allergens into CD1c+ epidermal cells. The pollen proteins were fluorescence labelled and applied on barrier-disrupted excised human skin. CD1c+ cells were selected after magnetic cell sorting and analysed using laser scanning microscopy. In untreated disrupted skin, 81% of the CD1c+ cells contained the fluorescence-labelled pollen allergens. In formulation-pretreated skin only 12% of the CD1c+ cells showed an uptake of pollen allergens. These results encourage the treatment of atopic patients with barrier-enhancing formulations to reduce the impact of pollen on air-exposed skin areas and hence the exacerbation of cutaneous symptoms.
[Mh] Termos MeSH primário: Alérgenos/metabolismo
Antígenos CD1/metabolismo
Corantes Fluorescentes/metabolismo
Glicoproteínas/metabolismo
Bases para Pomadas/metabolismo
Pólen/metabolismo
[Mh] Termos MeSH secundário: Administração Cutânea
Alérgenos/administração & dosagem
Antígenos CD1/administração & dosagem
Composição de Medicamentos
Corantes Fluorescentes/administração & dosagem
Glicoproteínas/administração & dosagem
Seres Humanos
Lipídeos/administração & dosagem
Lipídeos/farmacocinética
Bases para Pomadas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, CD1); 0 (CD1C protein, human); 0 (Fluorescent Dyes); 0 (Glycoproteins); 0 (Lipids); 0 (Ointment Bases); 8036-49-5 (eucerin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160331
[St] Status:MEDLINE
[do] DOI:10.1159/000444717


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[PMID]:26159459
[Au] Autor:LeBlanc P; Ghannoum JE
[Ad] Endereço:Faculty of Dental Medicine, University of Montreal, Montreal, QC, Canada. priscleblanc@gmail.com.
[Ti] Título:Myospherulosis of the Mandible Presenting as a Multilocular Lesion: A Case Report and Review of the Literature.
[So] Source:Head Neck Pathol;10(2):221-4, 2016 Jun.
[Is] ISSN:1936-0568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myospherulosis is an uncommon foreign body reaction that occurs in tissues exposed to antibiotic and oil-based ointments. Radiographic imaging of this lesion may suggest other diagnoses. Treatment consists of conservative surgical removal, and is usually curative. We report herein a case of myospherulosis presenting as an extremely unusual multilocular radiolucent lesion.
[Mh] Termos MeSH primário: Reação a Corpo Estranho/patologia
Doenças Mandibulares/patologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Bases para Pomadas/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ointment Bases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150711
[St] Status:MEDLINE
[do] DOI:10.1007/s12105-015-0641-1


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[PMID]:25975762
[Au] Autor:Eördögh R; Schwendenwein I; Tichy A; Loncaric I; Nell B
[Ad] Endereço:Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria.
[Ti] Título:Clinical effect of four different ointment bases on healthy cat eyes.
[So] Source:Vet Ophthalmol;19 Suppl 1:4-12, 2016 Jul.
[Is] ISSN:1463-5224
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To describe the effects of long-term treatment with four different eye ointment bases (OBs) in cats. ANIMALS STUDIED: Ten healthy cats. PROCEDURES: The study was performed in two periods. Four different OBs were tested. Hundred grams of OB contained the following: OB-A: 35.17 g liquid paraffin (lp), 64.83 g white petrolatum (wp); OB-B: 10.03 g lp, 84.95 g wp 5.02 g lanolin; OB-C: 18.34 g lp, 51.40 g wp, 25.00 mg KH2 PO4 , 57.00 mg K2 HPO4 , 18.90 g eucerinum anhydricum, 11.28 g water for injections; and OB-D: 70 g unguentum lanalcoli, 20 g lp, 10 g aqua conservans. One eye was treated, and the other served as a negative control. Cats received the OBs TID for 28 days. The two study periods were separated by a 4-month washout phase. Samples for conjunctival impression cytology, swabs for bacteriologic and mycologic examination, and cytobrush samples for FHV-1 and Chlamydophila felis PCR detection were obtained. Both eyes were examined daily. Severity of ocular symptoms was scored using a modified Draize eye irritation test. A total of five eyes were treated with OB-A, five with OB-B, four with OB-C, and five with OB-D. RESULTS: Treated eyes had significantly higher clinical scores. Eyes receiving OB-A had the highest overall clinical score. The results of bacteriologic and mycologic examination concur with the previously published data. All samples tested were negative for FHV-1 and Chlamydophila felis. There was no significant difference between treated and control eyes upon cytological examination. CONCLUSION: The application of OBs resulted in clinical symptoms in treated eyes. The long-term use of ointments is not well tolerated in cats and may lead to ocular irritation.
[Mh] Termos MeSH primário: Gatos
Olho/efeitos dos fármacos
Bases para Pomadas/farmacologia
[Mh] Termos MeSH secundário: Administração Oftálmica
Animais
Bactérias/isolamento & purificação
Olho/microbiologia
Feminino
Fungos/isolamento & purificação
Masculino
Bases para Pomadas/efeitos adversos
Bases para Pomadas/química
Fatores de Tempo
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ointment Bases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150516
[St] Status:MEDLINE
[do] DOI:10.1111/vop.12279


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[PMID]:24758140
[Au] Autor:Abou el Ela Ael S; Allam AA; Ibrahim EH
[Ad] Endereço:a Department of Pharmaceutics, Faculty of Pharmacy , King Saud University, Women Students - Medical Studies and Science Sections , Riyadh , Saudi Arabia and.
[Ti] Título:Pharmacokinetics and anti-hypertensive effect of metoprolol tartrate rectal delivery system.
[So] Source:Drug Deliv;23(1):69-78, 2016.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The main aim of this work was to develop rectal suppositories for better delivery of metoprolol tartrate (MT). The various bases used were fatty, water soluble and emulsion bases. The physical properties of the prepared suppositories were characterized such as weight variation, hardness, disintegration time, melting range and the drug content uniformity. The in vitro release of MT from the prepared suppositories was carried out. The evaluation of the pharmacological effects of MT on the blood pressure and heart rate of the healthy rabbits after the rectal administration compared to the oral tablets was studied. Moreover, the formulation with the highest in vitro release and the highest pharmacological effects would be selected for a further pharmacokinetics study compared to the oral tablets. The results revealed that the emulsion bases gave the highest rate of the drug release than the other bases used. The reduction effect of the emulsion MT suppository base on the blood pressure and heart rate was found to be faster and greater than that administered orally. The selected emulsion suppository base (F11) showed a significant increase in the AUC (1.88-fold) in rabbits as compared to the oral tablets. From the above results we can conclude that rectal route can serve as an efficient alternative route to the oral one for systemic delivery of MT which may be due to the avoidance of first-pass effect in the liver.
[Mh] Termos MeSH primário: Anti-Hipertensivos/administração & dosagem
Anti-Hipertensivos/farmacocinética
Metoprolol/administração & dosagem
Metoprolol/farmacocinética
[Mh] Termos MeSH secundário: Administração Retal
Animais
Pressão Sanguínea/efeitos dos fármacos
Química Farmacêutica
Sistemas de Liberação de Medicamentos
Emulsões
Frequência Cardíaca/efeitos dos fármacos
Bases para Pomadas
Coelhos
Solubilidade
Supositórios
Comprimidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Emulsions); 0 (Ointment Bases); 0 (Suppositories); 0 (Tablets); GEB06NHM23 (Metoprolol)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140425
[St] Status:MEDLINE
[do] DOI:10.3109/10717544.2014.904021


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[PMID]:26241753
[Au] Autor:Xu X; Al-Ghabeish M; Krishnaiah YS; Rahman Z; Khan MA
[Ad] Endereço:Division of Product Quality Research, OTR/OPQ, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. Electronic address: Xiaoming.Xu@fda.hhs.gov.
[Ti] Título:Kinetics of drug release from ointments: Role of transient-boundary layer.
[So] Source:Int J Pharm;494(1):31-9, 2015 Oct 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the current work, an in vitro release testing method suitable for ointment formulations was developed using acyclovir as a model drug. Release studies were carried out using enhancer cells on acyclovir ointments prepared with oleaginous, absorption, and water-soluble bases. Kinetics and mechanism of drug release was found to be highly dependent on the type of ointment bases. In oleaginous bases, drug release followed a unique logarithmic-time dependent profile; in both absorption and water-soluble bases, drug release exhibited linearity with respect to square root of time (Higuchi model) albeit differences in the overall release profile. To help understand the underlying cause of logarithmic-time dependency of drug release, a novel transient-boundary hypothesis was proposed, verified, and compared to Higuchi theory. Furthermore, impact of drug solubility (under various pH conditions) and temperature on drug release were assessed. Additionally, conditions under which deviations from logarithmic-time drug release kinetics occur were determined using in situ UV fiber-optics. Overall, the results suggest that for oleaginous ointments containing dispersed drug particles, kinetics and mechanism of drug release is controlled by expansion of transient boundary layer, and drug release increases linearly with respect to logarithmic time.
[Mh] Termos MeSH primário: Liberação Controlada de Fármacos
Pomadas/química
Preparações Farmacêuticas/química
[Mh] Termos MeSH secundário: Aciclovir/química
Química Farmacêutica/métodos
Excipientes
Concentração de Íons de Hidrogênio
Cinética
Bases para Pomadas/química
Física
Solubilidade
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Ointment Bases); 0 (Ointments); 0 (Pharmaceutical Preparations); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150924
[Lr] Data última revisão:
150924
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150805
[St] Status:MEDLINE



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