Base de dados : MEDLINE
Pesquisa : D26.878 [Categoria DeCS]
Referências encontradas : 9553 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 956 ir para página                         

  1 / 9553 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29214532
[Au] Autor:Bade R; White JM; Gerber C
[Ad] Endereço:School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide, South Australia, 5001, Australia.
[Ti] Título:Qualitative and quantitative temporal analysis of licit and illicit drugs in wastewater in Australia using liquid chromatography coupled to mass spectrometry.
[So] Source:Anal Bioanal Chem;410(2):529-542, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The combination of qualitative and quantitative bimonthly analysis of pharmaceuticals and illicit drugs using liquid chromatography coupled to mass spectrometry is presented. A liquid chromatography-quadrupole time of flight instrument equipped with Sequential Window Acquisition of all THeoretical fragment-ion spectra (SWATH) was used to qualitatively screen 346 compounds in influent wastewater from two wastewater treatment plants in South Australia over a 14-month period. A total of 100 compounds were confirmed and/or detected using this strategy, with 61 confirmed in all samples including antidepressants (amitriptyline, dothiepin, doxepin), antipsychotics (amisulpride, clozapine), illicit drugs (cocaine, methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA)), and known drug adulterants (lidocaine and tetramisole). A subset of these compounds was also included in a quantitative method, analyzed on a liquid chromatography-triple quadrupole mass spectrometer. The use of illicit stimulants (methamphetamine) showed a clear decrease, levels of opioid analgesics (morphine and methadone) remained relatively stable, while the use of new psychoactive substances (methylenedioxypyrovalerone (MDPV) and Alpha PVP) varied with no visible trend. This work demonstrates the value that high-frequency sampling combined with quantitative and qualitative analysis can deliver. Graphical abstract Temporal analysis of licit and illicit drugs in South Australia.
[Mh] Termos MeSH primário: Drogas Ilícitas/análise
Espectrometria de Massas em Tandem/métodos
Águas Residuais/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Austrália
Cromatografia Líquida/métodos
Extração em Fase Sólida/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs); 0 (Waste Water); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0747-2


  2 / 9553 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28455844
[Au] Autor:Keshet U; Alon T; Fialkov AB; Amirav A
[Ad] Endereço:School of Chemistry, Tel Aviv University, Tel Aviv, 69978, Israel.
[Ti] Título:Open Probe fast GC-MS - combining ambient sampling ultra-fast separation and in-vacuum ionization for real-time analysis.
[So] Source:J Mass Spectrom;52(7):417-426, 2017 Jul.
[Is] ISSN:1096-9888
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An Open Probe inlet was combined with a low thermal mass ultra-fast gas chromatograph (GC), in-vacuum electron ionization ion source and a mass spectrometer (MS) of GC-MS for obtaining real-time analysis with separation. The Open Probe enables ambient sampling via sample vaporization in an oven that is open to room air, and the ultra-fast GC provides ~30-s separation, while if no separation is required, it can act as a transfer line with 2 to 3-s sample transfer time. Sample analysis is as simple as touching the sample, pushing the sample holder into the Open Probe oven and obtaining the results in 30 s. The Open Probe fast GC was mounted on a standard Agilent 7890 GC that was coupled with an Agilent 5977A MS. Open Probe fast GC-MS provides real-time analysis combined with GC separation and library identification, and it uses the low-cost MS of GC-MS. The operation of Open Probe fast GC-MS is demonstrated in the 30-s separation and 50-s full analysis cycle time of tetrahydrocannabinol and cannabinol in Cannabis flower, sub 1-min analysis of trace trinitrotoluene transferred from a finger onto a glass surface, vitamin E in canola oil, sterols in olive oil, polybrominated flame retardants in plastics, alprazolam in Xanax drug pill and free fatty acids and cholesterol in human blood. The extrapolated limit of detection for pyrene is <1 fg, but the concentration is too high and the software noise calculation is untrustworthy. The broad range of compounds amenable for analysis is demonstrated in the analysis of reserpine. The possible use with alternate standard GC-MS and Open Probe fast GC-MS is demonstrated in the analysis of heroin in its street drug powder. The use of Open Probe with the fast GC acting as a transfer line is demonstrated in <10-s analysis without separation of ibuprofen and estradiol. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas/instrumentação
Cromatografia Gasosa-Espectrometria de Massas/métodos
Compostos Orgânicos/análise
[Mh] Termos MeSH secundário: Ionização do Ar
Seres Humanos
Limite de Detecção
Preparações Farmacêuticas/análise
Preparações Farmacêuticas/química
Drogas Ilícitas/análise
Drogas Ilícitas/química
Vácuo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organic Chemicals); 0 (Pharmaceutical Preparations); 0 (Street Drugs)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1002/jms.3941


  3 / 9553 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29368473
[Au] Autor:Sharma ER; Shuler FD; Loudin S
[Ti] Título:Legal Aspects of Neonatal Abstinence Syndrome.
[So] Source:W V Med J;112(5):19, 2016 Sep-Oct.
[Is] ISSN:0043-3284
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Controle de Medicamentos e Entorpecentes/legislação & jurisprudência
Tempo de Internação/legislação & jurisprudência
Síndrome de Abstinência Neonatal
Admissão do Paciente/legislação & jurisprudência
Complicações na Gravidez
[Mh] Termos MeSH secundário: Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido
Unidades de Terapia Intensiva Neonatal
Tempo de Internação/estatística & dados numéricos
Síndrome de Abstinência Neonatal/epidemiologia
Síndrome de Abstinência Neonatal/etiologia
Admissão do Paciente/estatística & dados numéricos
Gravidez
Complicações na Gravidez/epidemiologia
Complicações na Gravidez/etiologia
Prevalência
Psicotrópicos/efeitos adversos
Drogas Ilícitas/efeitos adversos
Drogas Ilícitas/legislação & jurisprudência
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/etiologia
West Virginia/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; EDITORIAL
[Nm] Nome de substância:
0 (Psychotropic Drugs); 0 (Street Drugs)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  4 / 9553 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29289268
[Au] Autor:Kamal F; Snook L; Saikumar JH
[Ad] Endereço:University of Tennessee Health Science Center (FK, JS), Memphis, Memphis, Tennessee. Electronic address: fkamal1@uthsc.edu.
[Ti] Título:Rhabdomyolysis-Associated Acute Kidney Injury With Normal Creatine Phosphokinase.
[So] Source:Am J Med Sci;355(1):84-87, 2018 Jan.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rhabdomyolysis is a syndrome characterized by the breakdown of skeletal muscle and leakage of intracellular myocyte contents, such as creatine phosphokinase (CPK) and myoglobin, into the interstitial space and plasma resulting in acute kidney injury (AKI). Elevated CPK of at least 5 times the upper limit of normal is an important diagnostic marker of Rhabdomyolysis. We present a case of rhabdomyolysis with severe AKI with a normal CPK at presentation. A 32-year-old man presented with acute respiratory failure and AKI after an overdose of recreational drugs. Urinalysis at presentation showed trace amounts of blood, identified as rare red blood cells under microscopy. CPK was 156 U/L at presentation. Workup for glomerulonephritis and vasculitis was negative. He was initiated on renal replacement therapy, and a kidney biopsy showed severe acute tubular injury with positive myoglobin casts. Supportive management and renal replacement therapy was provided, and renal function spontaneously improved after a few weeks. This is an uncommon clinical presentation of severe rhabdomyolysis complicated by AKI. This suggests that CPK alone may not be a sensitive marker for rhabdomyolysis-induced AKI in some cases.
[Mh] Termos MeSH primário: Lesão Renal Aguda
Creatina Quinase/sangue
Overdose de Drogas
Terapia de Substituição Renal
Rabdomiólise
Drogas Ilícitas/efeitos adversos
[Mh] Termos MeSH secundário: Lesão Renal Aguda/sangue
Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/terapia
Adulto
Biomarcadores/sangue
Overdose de Drogas/sangue
Overdose de Drogas/complicações
Overdose de Drogas/terapia
Seres Humanos
Masculino
Rabdomiólise/sangue
Rabdomiólise/induzido quimicamente
Rabdomiólise/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Street Drugs); EC 2.7.3.2 (Creatine Kinase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


  5 / 9553 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29384873
[Au] Autor:Liakoni E; Yates C; Dines AM; Dargan PI; Heyerdahl F; Hovda KE; Wood DM; Eyer F; Liechti ME; Euro-DEN Plus Research Group
[Ad] Endereço:Division of Clinical Pharmacology and Toxicology, Basel University Hospital and University of Basel, Basel, Switzerland.
[Ti] Título:Acute recreational drug toxicity: Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series.
[So] Source:Medicine (Baltimore);97(5):e9784, 2018 02.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity.We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over 2 years (October 2013 to September 2015) within the European Drug Emergencies Network Plus project.Among the 10,956 cases of acute recreational drug toxicity during the study period, 831 could be included. Between the self-reported substance use and the toxicological results, the highest agreement was found for heroin (86.1%) and cocaine (74.1%), whereas inhalants, poppers, and magic mushrooms were self-reported but not analytically detected. Cathinones and other new psychoactive substances (NPS) could be detected using additional analytical methods. Among cases with both immunoassay (IA) and confirmation with mass spectrometry (MS), the results were consistent for methadone (100%) and cocaine (95.5%) and less consistent for amphetamines (81.8%). In cases with a positive IA for amphetamines (n = 54), MS confirmed the presence of 3,4-methylenedioxymethamphetamine (MDMA), amphetamine, methamphetamine, and NPS in 37, 20, 10, and 6 cases, respectively, also revealing use of more than 1 substance in some cases. MS yielded positive results in 21 cases with a negative IA for amphetamines, including amphetamine, MDMA, methamphetamine, and NPS, in 14, 7, 2, and 2 cases, respectively.In conclusion, the highest agreement was found between self-reports and analytical findings for heroin and cocaine. The diagnosis of NPS use was mainly based on self-report. The IAs accurately identified methadone and cocaine, and MS had advantages for the detection of NPS and amphetamine derivatives.
[Mh] Termos MeSH primário: Drogas Ilícitas/envenenamento
Transtornos Relacionados ao Uso de Substâncias/complicações
Transtornos Relacionados ao Uso de Substâncias/diagnóstico
[Mh] Termos MeSH secundário: Doença Aguda
Serviço Hospitalar de Emergência
Europa (Continente)
Seres Humanos
Imunoensaio
Espectrometria de Massas
Reprodutibilidade dos Testes
Estudos Retrospectivos
Autorrelato
Transtornos Relacionados ao Uso de Substâncias/psicologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Street Drugs)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009784


  6 / 9553 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29277574
[Au] Autor:Caspar AT; Meyer MR; Maurer HH
[Ad] Endereço:Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany.
[Ti] Título:Human cytochrome P450 kinetic studies on six N-2-methoxybenzyl (NBOMe)-derived new psychoactive substances using the substrate depletion approach.
[So] Source:Toxicol Lett;285:1-8, 2018 Mar 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A huge number of new chemical derivatives of known drugs of abuse, so-called new psychoactive substances (NPS), are sold and consumed without prior preclinical and clinical testing. For assessing the elimination behaviors, determination of the kinetic constants K and V of the cytochrome P450 (CYP) isoforms involved in the hepatic metabolism of NPS could help to predict their contributions to hepatic clearance, drug-drug interactions and polymorphisms. Therefore, the aims of the present study were to determine the K and V values for CYP isoforms using the substrate depletion approach for the six N-2-methoxybenzyl (NBOMe)-derived NPS 25B-NBOMe, 25C-NBOMe, 25I-NBOMe, 3,4-DMA-NBOMe, 4-EA-NBOMe, and 4-MMA-NBOMe. Furthermore, the contributions of each CYP isozyme to the hepatic net clearance were elucidated using the relative activity factor approach. Several CYPs including CYP1A2, CYP2B6, CYP2C19, CYP2D6, and CYP3A4 were identified to be involved in the metabolism of the investigated compounds. The determined K values ranged from 0.010 µM (CYP2D6, 4-MMA-NBOMe) to 13 µM (CYP2B6, 4-EA-NBOMe). All NBOMes were good substrates of CYP2C19 and CYP2D6 resulting in very low K values in the nanomolar range. The main contributors to hepatic net clearance were CYP2D6 for 25B-NBOMe (69%), 25C-NBOMe (83%), 25I-NBOMe (61%), 3,4-DMA-NBOMe (89%) as well as for 4-EA-NBOMe (62%) and CYP2C19 for 4-MMA-NBOMe (64%). As more than one isoform was involved in the particular steps, the risk of harm associated with drug-drug interactions might be considered low. However, in cases where substances with high contributions from polymorphically expressed CYP2C19 and CYP2D6 are encountered, inter-individual variations in metabolism and excretion cannot be excluded.
[Mh] Termos MeSH primário: Compostos de Benzil/farmacocinética
Sistema Enzimático do Citocromo P-450/metabolismo
Microssomos Hepáticos/enzimologia
Psicotrópicos/farmacocinética
Drogas Ilícitas/farmacocinética
[Mh] Termos MeSH secundário: Animais
Compostos de Benzil/química
Sistema Enzimático do Citocromo P-450/genética
Interações Medicamentosas
Seres Humanos
Técnicas In Vitro
Cinética
Taxa de Depuração Metabólica
Microssomos Hepáticos/metabolismo
Modelos Biológicos
Psicotrópicos/química
Drogas Ilícitas/química
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzyl Compounds); 0 (Psychotropic Drugs); 0 (Street Drugs); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


  7 / 9553 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29188674
[Au] Autor:Ding BF; Shao L; Zhang RS; Liang C; Zhang YR
[Ad] Endereço:College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China.
[Ti] Título:[Research Progress on Abused Drugs Metabolic in vivo].
[So] Source:Fa Yi Xue Za Zhi;32(4):290-295, 2016 Aug.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Under the catalysis of a variety of metabolic enzymes , such as UDP-glucuronyl transferases, cytochrome P450, carboxylesterase, sulfotransferase, butyrylcholinesterase, catechol- -methyl transferase and 6-morphine dehydrogenase, the drugs perform glucuronidation, hydrolysis, oxidation, sulfonation and other reactions, then translate into active or inactive metabolites, which are excreted through urination, bile or the other pathways at last. Different drugs own their different metabolic pathways. This paper introduces the studies about the metabolism of drugs in human and animal in recent years, such as morphine-like drugs, amphetamine, ketamine, cannabis and cocaine, and reviews the research progress about the sites of metabolism, metabolic enzymes, metabolites and physiological activity of those drugs metabolic .
[Mh] Termos MeSH primário: Colinesterases/metabolismo
Sistema Enzimático do Citocromo P-450/metabolismo
Glucuronosiltransferase/metabolismo
Drogas Ilícitas/metabolismo
[Mh] Termos MeSH secundário: Oxirredutases do Álcool/metabolismo
Animais
Carboxilesterase/metabolismo
Catecol O-Metiltransferase/metabolismo
Seres Humanos
Oxirredução
Sulfotransferases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Street Drugs); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.1.- (Alcohol Oxidoreductases); EC 1.1.1.218 (morphine 6-dehydrogenase); EC 2.1.1.6 (Catechol O-Methyltransferase); EC 2.4.1.17 (Glucuronosyltransferase); EC 2.8.2.- (Sulfotransferases); EC 3.1.1.1 (Carboxylesterase); EC 3.1.1.8 (Cholinesterases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.04.013


  8 / 9553 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29393308
[Au] Autor:Farrell CM; Cucu DF
[Ad] Endereço:Resident Physician, Northwestern University.
[Ti] Título:Cocaine-Related Acute Spinal Cord Infarction.
[So] Source:R I Med J (2013);101(1):28-29, 2018 Feb 02.
[Is] ISSN:2327-2228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report a rare case of anterior spinal artery syndrome in the setting of acute cocaine use. A 31-year-old man presented to the hospital unarousable with leukocytosis and a positive toxicology screen for opioids, cocaine, benzodiazepines and cannabis. He was placed on intravenous naloxone. As the patient regained consciousness, he was found to have paraplegia, sensory loss below the level of T5, and urinary retention. MRI findings showed a signal intensity abnormality from the level of T1-4, highly suggestive of an acute ischemic spinal cord infarct. [Full article available at http://rimed.org/rimedicaljournal-2018-02.asp].
[Mh] Termos MeSH primário: Síndrome da Artéria Espinal Anterior/induzido quimicamente
Transtornos Relacionados ao Uso de Cocaína/complicações
Cocaína/toxicidade
Drogas Ilícitas/toxicidade
[Mh] Termos MeSH secundário: Adulto
Síndrome da Artéria Espinal Anterior/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


  9 / 9553 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29233278
[Au] Autor:Miller LN; Mercer SL
[Ad] Endereço:Department of Pharmacy Practice, Lipscomb University College of Pharmacy and Health Sciences, One University Park Drive, Nashville, TN 37204, United States; Vanderbilt University Medical Center, Nashville, TN 37232, United States. Electronic address: lindsey.miller@lipscomb.edu.
[Ti] Título:Drugs of Abuse and Addiction: An integrated approach to teaching.
[So] Source:Curr Pharm Teach Learn;9(3):405-414, 2017 May.
[Is] ISSN:1877-1300
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: To describe the design, implementation, and student perceptions of a Drugs of Abuse and Addiction elective course utilizing an integrated teaching model. EDUCATIONAL ACTIVITY AND SETTING: Third-year pharmacy students enrolled in the two credit hour elective. Teaching methodology included didactic lecture, journal club, simulated addiction assignment with reflection, debates, external speakers, site visit to a residential drug court program and research paper with presentation. FINDINGS: A course objective survey was administered upon course completion. All students strongly agreed that having science- and clinical-based faculty members develop and deliver course content was beneficial. Additionally, all students agree to strongly agree that their research project helped them integrate and comprehend the science and practice surrounding drugs of abuse and addiction. DISCUSSION AND SUMMARY: Students enjoyed an integrated teaching approach and multiple teaching methodologies leading to increased engagement and enhancement of student learning. Course enrollment was beneficial for personalized learning, but limited student perspective.
[Mh] Termos MeSH primário: Educação em Farmácia/métodos
Drogas Ilícitas
Estudantes de Farmácia
Transtornos Relacionados ao Uso de Substâncias
[Mh] Termos MeSH secundário: Comportamento Aditivo
Comportamento do Consumidor
Currículo
Seres Humanos
Drogas Ilícitas/química
Drogas Ilícitas/farmacologia
Transtornos Relacionados ao Uso de Substâncias/terapia
Inquéritos e Questionários
Ensino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  10 / 9553 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:29319947
[Au] Autor:Drug Enforcement Administration, Department of Justice.
[Ti] Título:Schedules of Controlled Substances: Temporary Placement of Cyclopropyl Fentanyl in Schedule I. Temporary amendment; temporary scheduling order.
[So] Source:Fed Regist;83(3):469-72, 2018 Jan 04.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Administrator of the Drug Enforcement Administration is issuing this temporary scheduling order to schedule the synthetic opioid, -(1-phenethylpiperidin-4-yl)-N-phenylcyclopropanecarboxamide (cyclopropyl fentanyl), and its isomers, esters, ethers, salts, and salts of isomers, esters, and ethers in schedule I. This action is based on a finding by the Administrator that the placement of cyclopropyl fentanyl in schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle, cyclopropyl fentanyl.
[Mh] Termos MeSH primário: Analgésicos Opioides/análise
Analgésicos Opioides/classificação
Controle de Medicamentos e Entorpecentes/legislação & jurisprudência
Fentanila/análogos & derivados
Fentanila/classificação
[Mh] Termos MeSH secundário: Seres Humanos
Drogas Ilícitas/efeitos adversos
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Street Drugs); UF599785JZ (Fentanyl)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE



página 1 de 956 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde