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  1 / 26540 MEDLINE  
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[PMID]:29184999
[Au] Autor:Oya M; Suzuki H; Anas ARJ; Oishi K; Ono K; Yamaguchi S; Eguchi M; Sawada M
[Ad] Endereço:Department of Brain Function, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8601, Japan.
[Ti] Título:LC-MS/MS imaging with thermal film-based laser microdissection.
[So] Source:Anal Bioanal Chem;410(2):491-499, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Mass spectrometry (MS) imaging is a useful tool for direct and simultaneous visualization of specific molecules. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to evaluate the abundance of molecules in tissues using sample homogenates. To date, however, LC-MS/MS has not been utilized as an imaging tool because spatial information is lost during sample preparation. Here we report a new approach for LC-MS/MS imaging using a thermal film-based laser microdissection (LMD) technique. To isolate tissue spots, our LMD system uses a 808-nm near infrared laser, the diameter of which can be freely changed from 2.7 to 500 µm; for imaging purposes in this study, the diameter was fixed at 40 µm, allowing acquisition of LC-MS/MS images at a 40-µm resolution. The isolated spots are arranged on a thermal film at 4.5-mm intervals, corresponding to the well spacing on a 384-well plate. Each tissue spot is handled on the film in such a manner as to maintain its spatial information, allowing it to be extracted separately in its individual well. Using analytical LC-MS/MS in combination with the spatial information of each sample, we can reconstruct LC-MS/MS images. With this imaging technique, we successfully obtained the distributions of pilocarpine, glutamate, γ-aminobutyric acid, acetylcholine, and choline in a cross-section of mouse hippocampus. The protocol we established in this study is applicable to revealing the neurochemistry of pilocarpine model of epilepsy. Our system has a wide range of uses in fields such as biology, pharmacology, pathology, and neuroscience. Graphical abstract Schematic Indication of LMD-LC-MS/MS imaging.
[Mh] Termos MeSH primário: Hipocampo/química
Microdissecção e Captura a Laser/métodos
Neurotransmissores/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Acetilcolina/análise
Animais
Colina/análise
Cromatografia Líquida/métodos
Epilepsia/diagnóstico
Epilepsia/patologia
Feminino
Ácido Glutâmico/análise
Hipocampo/patologia
Camundongos Endogâmicos C57BL
Pilocarpina/análise
Ácido gama-Aminobutírico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotransmitter Agents); 01MI4Q9DI3 (Pilocarpine); 3KX376GY7L (Glutamic Acid); 56-12-2 (gamma-Aminobutyric Acid); N91BDP6H0X (Choline); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0739-2


  2 / 26540 MEDLINE  
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[PMID]:28749489
[Au] Autor:Stragierowicz J; Daragó A; Brzeznicki S; Kilanowicz A
[Ad] Endereço:Medical University of Lodz, Lódz, Poland (Faculty of Pharmacy, Department of Toxicology). joanna.stragierowicz@umed.lodz.pl.
[Ti] Título:Optimization of ultra-performance liquid chromatography (UPLC) with fluorescence detector (FLD) method for the quantitative determination of selected neurotransmitters in rat brain.
[Ti] Título:Optimization of ultra-performance liquid chromatography (UPLC) with fluorescence detector (FLD) method for the quantitative determination of selected neurotransmitters in rat brain..
[So] Source:Med Pr;68(5):583-591, 2017 Jul 26.
[Is] ISSN:0465-5893
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Glutamate (Glu) and γ-aminobutyric acid (GABA) are the main neurotransmitters in the central nervous system for excitatory and inhibitory processes, respectively. Monitoring these neurotransmitters is an essential tool in establishing pathological functions, among others in terms of occupational exposure to toxic substances. MATERIAL AND METHODS: We present modification of the HPLC (high-performance liquid chromatography) to the UPLC (ultra-performance liquid chromatography) method for the simultaneous determination of glutamate and γ-aminobutyric acid in a single injection. The isocratic separation of these neurotransmitter derivatives was performed on Waters Acquity BEH (ethylene bridged hybrid) C18 column with particle size of 1.7 µm at 35°C using a mobile phase consisting of 0.1 M acetate buffer (pH 6.0) and methanol (60:40, v/v) at a flow rate of 0.3 ml/min. The analytes were detected with the fluorescence detector (FLD) using derivatization with o-phthaldialdehyde (OPA), resulting in excitation at 340 nm and emission at 455 nm. RESULTS: Several validation parameters including linearity (0.999), accuracy (101.1%), intra-day precision (1.52-1.84%), inter-day precision (2.47-3.12%), limit of detection (5-30 ng/ml) and quantification (100 ng/ml) were examined. The developed method was also used for the determination of these neurotransmitters in homogenates of selected rat brain structures. CONCLUSIONS: The presented UPLC-FLD is characterized by shorter separation time (3.5 min), which is an adaptation of the similar HPLC methods and is an alternative for more expensive references techniques such as liquid chromatography coupled with tandem mass-spectrometry (LC-MS/MS) methods. Med Pr 2017;68(5):583-591.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Ácido Glutâmico/análise
Extração Líquido-Líquido/métodos
Neurotransmissores/análise
Ácido gama-Aminobutírico/análise
[Mh] Termos MeSH secundário: Animais
Ratos
Padrões de Referência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotransmitter Agents); 3KX376GY7L (Glutamic Acid); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


  3 / 26540 MEDLINE  
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[PMID]:29351866
[Au] Autor:Konieczna L; Roszkowska A; Stachowicz-Stencel T; Synakiewicz A; Baczek T
[Ad] Endereço:Department of Pharmaceutical Chemistry, Medical University of Gdansk, Hallera 107 Str., 80-416 Gdansk, Poland.
[Ti] Título:Bioanalysis of a panel of neurotransmitters and their metabolites in plasma samples obtained from pediatric patients with neuroblastoma and Wilms' tumor.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1074-1075:99-110, 2018 Feb 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper details the quantitative analysis of neurotransmitters, including dopamine (DA), norepinephrine (NE), epinephrine (E), and serotonin (5-HT), along with their respective precursors and metabolites in children with solid tumors: Wilms' tumor (WT) and neuroblastoma (NB). A panel of neurotransmitters was determined with the use of dispersive liquid-liquid microextraction (DLLME) technique combined with liquid-chromatography mass spectrometry (LC-MS/MS) in plasma samples obtained from a group of pediatric subjects with solid tumors and a control group of healthy children. Next, statistical univariate analysis (t-test) and multivariate analysis (Principal Component Analysis) were performed using chromatographic data. The levels of tyrosine (Tyr) and tryptophan (Trp) (the precursors of analyzed neurotransmitters) as well as 3,4-dihydroxyphenylacetic acid (DOPAC) (a product of metabolism of DA) were significantly higher in the plasma samples obtained from pediatric patients with WT than in the samples taken from the control group. Moreover, statistically significant differences were observed between the levels of 5-HT and homovanillic acid (HVA) in the plasma samples from pediatric patients with solid tumors and the control group. However, elevated levels of these analytes did not facilitate a clear distinction between pediatric patients with WT and those with NB. Nonetheless, the application of advanced statistical tools allowed the healthy controls to be differentiated from the pediatric oncological patients. The identification and quantification of a panel of neurotransmitters as potential prognostic factors in selected childhood malignancies may provide clinically relevant information about ongoing metabolic alterations, and it could potentially serve as an adjunctive strategy in the effective diagnosis and treatment of solid tumors in children.
[Mh] Termos MeSH primário: Neuroblastoma/metabolismo
Neurotransmissores/sangue
Tumor de Wilms/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Cromatografia Líquida de Alta Pressão
Seres Humanos
Lactente
Recém-Nascido
Limite de Detecção
Modelos Lineares
Neuroblastoma/sangue
Neurotransmissores/química
Neurotransmissores/metabolismo
Análise de Componente Principal
Reprodutibilidade dos Testes
Espectrometria de Massas em Tandem
Tumor de Wilms/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotransmitter Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE


  4 / 26540 MEDLINE  
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[PMID]:29275172
[Au] Autor:Forgacsova A; Galba J; Garruto RM; Majerova P; Katina S; Kovac A
[Ad] Endereço:Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy of Comenius University, Odbojarov 10, 832 32, Bratislava, Slovak Republic. Electronic address: andrej.kovac@savba.sk.
[Ti] Título:A novel liquid chromatography/mass spectrometry method for determination of neurotransmitters in brain tissue: Application to human tauopathies.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1073:154-162, 2018 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Neurotransmitters, small molecules widely distributed in the central nervous system are essential in transmitting electrical signals across neurons via chemical communication. Dysregulation of these chemical signaling molecules is linked to numerous neurological diseases including tauopathies. In this study, a precise and reliable liquid chromatography method was established with tandem mass spectrometry detection for the simultaneous determination of aspartic acid, asparagine, glutamic acid, glutamine, γ-aminobutyric acid, N-acetyl-l-aspartic acid, pyroglutamic acid, acetylcholine and choline in human brain tissue. The method was successfully applied to the analysis of human brain tissues from three different tauopathies; corticobasal degeneration, progressive supranuclear palsy and parkinsonism-dementia complex of Guam. Neurotransmitters were analyzed on ultra-high performance chromatography (UHPLC) using an ethylene bridged hybrid amide column coupled with tandem mass spectrometry (MS/MS). Identification and quantification of neurotransmitters was carried out by ESI+ mass spectrometry detection. We optimized sample preparation to achieve simple and fast extraction of all nine analytes. Our method exhibited an excellent linearity for all analytes (all coefficients of determination >0.99), with inter-day and intra-day precision yielding relative standard deviations 3.2%-11.2% and an accuracy was in range of 92.6%-104.3%. The present study, using the above method, is the first to demonstrate significant alterations of brain neurotransmitters caused by pathological processes in the brain tissues of patient with three different tauopathies.
[Mh] Termos MeSH primário: Química Encefálica/fisiologia
Cromatografia Líquida/métodos
Espectrometria de Massas/métodos
Neurotransmissores/análise
Tauopatias/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Limite de Detecção
Modelos Lineares
Neurotransmissores/metabolismo
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotransmitter Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171225
[St] Status:MEDLINE


  5 / 26540 MEDLINE  
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[PMID]:28452419
[Au] Autor:Joshi S; Rajasekaran K; Williamson J; Kapur J
[Ad] Endereço:Department of Neurology, University of Virginia, Charlottesville, Virginia, U.S.A.
[Ti] Título:Neurosteroid-sensitive δ-GABA receptors: A role in epileptogenesis?
[So] Source:Epilepsia;58(3):494-504, 2017 03.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We determined the role of the neurosteroid-sensitive δ subunit-containing γ-aminobutyric acid A receptors (δ-GABARs) in epileptogenesis. METHODS: Status epilepticus (SE) was induced via lithium pilocarpine in adult rats, and seizures were assessed by continuous video-electroencephalography (EEG) monitoring. Finasteride was administered to inhibit neurosteroid synthesis. The total and surface protein expression of hippocampal δ, α4, and γ2 GABAR subunits was studied using biotinylation assays and Western blotting. Neurosteroid potentiation of the tonic currents of dentate granule cells (DGCs) was measured by whole-cell patch-clamp technique. Finally, the effects of inhibiting N-methyl-d-aspartate receptors (NMDARs) during SE on the long-term plasticity of δ-GABARs, neurosteroid-induced modulation of tonic current, and epileptogenesis were studied. RESULTS: The inhibition of neurosteroid synthesis 4 days after SE triggered acute seizures and accelerated the onset of chronic recurrent spontaneous seizures (epilepsy). The down-regulation of neurosteroid-sensitive δ-GABARs occurred prior to the onset of epilepsy, whereas an increased expression of the γ2-GABAR subunits occurred after seizure onset. MK801 blockade of NMDARs during SE preserved the expression of neurosteroid-sensitive δ-GABARs. NMDAR blockade during SE also prevented the onset of spontaneous seizures. SIGNIFICANCE: Changes in neurosteroid-sensitive δ-GABAR expression correlated temporally with epileptogenesis. These findings raise the possibility that δ-GABAR plasticity may play a role in epileptogenesis.
[Mh] Termos MeSH primário: Epilepsia do Lobo Temporal/fisiopatologia
Neurotransmissores/fisiologia
Receptores de GABA-A/fisiologia
Estado Epiléptico/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Giro Denteado/fisiopatologia
Modelos Animais de Doenças
Maleato de Dizocilpina/farmacologia
Regulação para Baixo/efeitos dos fármacos
Regulação para Baixo/fisiologia
Eletroencefalografia/efeitos dos fármacos
Feminino
Finasterida/farmacologia
Hipocampo/fisiopatologia
Compostos de Lítio
Masculino
Plasticidade Neuronal/efeitos dos fármacos
Plasticidade Neuronal/fisiologia
Neurônios/efeitos dos fármacos
Neurônios/fisiologia
Neurotransmissores/antagonistas & inibidores
Técnicas de Patch-Clamp
Pilocarpina
Ratos
Ratos Sprague-Dawley
Receptores de N-Metil-D-Aspartato/antagonistas & inibidores
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lithium Compounds); 0 (Neurotransmitter Agents); 0 (Receptors, GABA-A); 0 (Receptors, N-Methyl-D-Aspartate); 01MI4Q9DI3 (Pilocarpine); 57GNO57U7G (Finasteride); 6LR8C1B66Q (Dizocilpine Maleate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13660


  6 / 26540 MEDLINE  
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[PMID]:29223589
[Au] Autor:Blanco MJ; La D; Coughlin Q; Newman CA; Griffin AM; Harrison BL; Salituro FG
[Ad] Endereço:Sage Therapeutics, Inc., 215 First Street, Cambridge, MA 02142, USA. Electronic address: Maria-Jesus.Blanco@sagerx.com.
[Ti] Título:Breakthroughs in neuroactive steroid drug discovery.
[So] Source:Bioorg Med Chem Lett;28(2):61-70, 2018 01 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Endogenous and synthetic neuroactive steroids (NASs) or neurosteroids are effective modulators of multiple signaling pathways including receptors for the γ-aminobutyric acid A (GABA ) and glutamate, in particular N-methyl-d-aspartate (NMDA). These receptors are the major inhibitory and excitatory neurotransmitters in the central nervous system (CNS), and there is growing evidence suggesting that dysregulation of neurosteroid production plays a role in numerous neurological disorders. The significant unmet medical need for treatment of CNS disorders has increased the interest for these types of compounds. In this review, we highlight recent progress in the clinical development of NAS drug candidates, in addition to preclinical breakthroughs in the identification of novel NASs, mainly for GABA and NMDA receptor modulation.
[Mh] Termos MeSH primário: Doenças do Sistema Nervoso Central/tratamento farmacológico
Descoberta de Drogas
Neurotransmissores/farmacologia
Receptores de GABA-A/metabolismo
Receptores de N-Metil-D-Aspartato/metabolismo
[Mh] Termos MeSH secundário: Animais
Doenças do Sistema Nervoso Central/metabolismo
Relação Dose-Resposta a Droga
Seres Humanos
Conformação Molecular
Neurotransmissores/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Neurotransmitter Agents); 0 (Receptors, GABA-A); 0 (Receptors, N-Methyl-D-Aspartate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


  7 / 26540 MEDLINE  
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[PMID]:28461682
[Au] Autor:Hull C
[Ad] Endereço:Department of Neurobiology, Duke University, Durham, North Carolina 27710 Hull@neuro.duke.edu.
[Ti] Título:Cellular and Synaptic Properties of Local Inhibitory Circuits.
[So] Source:Cold Spring Harb Protoc;2017(5):pdb.top095281, 2017 May 01.
[Is] ISSN:1559-6095
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inhibitory interneurons play a key role in sculpting the information processed by neural circuits. Despite the wide range of physiologically and morphologically distinct types of interneurons that have been identified, common principles have emerged that have shed light on how synaptic inhibition operates, both mechanistically and functionally, across cell types and circuits. This introduction summarizes how electrophysiological approaches have been used to illuminate these key principles, including basic interneuron circuit motifs, the functional properties of inhibitory synapses, and the main roles for synaptic inhibition in regulating neural circuit function. It also highlights how some key electrophysiological methods and experiments have advanced our understanding of inhibitory synapse function.
[Mh] Termos MeSH primário: Fenômenos Eletrofisiológicos/fisiologia
Neurônios/fisiologia
Sinapses/fisiologia
[Mh] Termos MeSH secundário: Animais
Excitabilidade Cortical/fisiologia
Potenciais Evocados
Interneurônios/fisiologia
Potenciais da Membrana/fisiologia
Neurônios Motores/fisiologia
Neurotransmissores/fisiologia
Transmissão Sináptica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotransmitter Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1101/pdb.top095281


  8 / 26540 MEDLINE  
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[PMID]:28452955
[Au] Autor:Grässel S; Muschter D
[Ad] Endereço:Department of Orthopedic Surgery, Exp. Orthopedics, ZMB/Biopark 1, University of Regensburg, 93053 Regensburg, Germany. susanne.graessel@ukr.de.
[Ti] Título:Peripheral Nerve Fibers and Their Neurotransmitters in Osteoarthritis Pathology.
[So] Source:Int J Mol Sci;18(5), 2017 Apr 28.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The importance of the nociceptive nervous system for maintaining tissue homeostasis has been known for some time, and it has also been suggested that organogenesis and tissue repair are under neuronal control. Changes in peripheral joint innervation are supposed to be partly responsible for degenerative alterations in joint tissues which contribute to development of osteoarthritis. Various resident cell types of the musculoskeletal system express receptors for sensory and sympathetic neurotransmitters, allowing response to peripheral neuronal stimuli. Among them are mesenchymal stem cells, synovial fibroblasts, bone cells and chondrocytes of different origin, which express distinct subtypes of adrenoceptors (AR), receptors for vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP). Some of these cell types synthesize and secrete neuropeptides such as SP, and they are positive for tyrosine-hydroxylase (TH), the rate limiting enzyme for biosynthesis of catecholamines. Sensory and sympathetic neurotransmitters are involved in the pathology of inflammatory diseases such as rheumatoid arthritis (RA) which manifests mainly in the joints. In addition, they seem to play a role in pathogenesis of priori degenerative joint disorders such as osteoarthritis (OA). Altogether it is evident that sensory and sympathetic neurotransmitters have crucial trophic effects which are critical for joint tissue and bone homeostasis. They modulate articular cartilage, subchondral bone and synovial tissue properties in physiological and pathophysiological conditions, in addition to their classical neurological features.
[Mh] Termos MeSH primário: Neurotransmissores/metabolismo
Osteoartrite/patologia
Nervos Periféricos/metabolismo
[Mh] Termos MeSH secundário: Peptídeo Relacionado com Gene de Calcitonina/metabolismo
Condrócitos/citologia
Condrócitos/metabolismo
Seres Humanos
Neuropeptídeos/metabolismo
Osteoartrite/metabolismo
Receptores Adrenérgicos/metabolismo
Substância P/metabolismo
Peptídeo Intestinal Vasoativo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Neuropeptides); 0 (Neurotransmitter Agents); 0 (Receptors, Adrenergic); 33507-63-0 (Substance P); 37221-79-7 (Vasoactive Intestinal Peptide); 83652-28-2 (Calcitonin Gene-Related Peptide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  9 / 26540 MEDLINE  
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[PMID]:29208223
[Au] Autor:Donlea JM
[Ad] Endereço:Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095-1763, USA. Electronic address: jdonlea@ucla.edu.
[Ti] Título:Neuronal and molecular mechanisms of sleep homeostasis.
[So] Source:Curr Opin Insect Sci;24:51-57, 2017 Dec.
[Is] ISSN:2214-5753
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sleep is necessary for survival, and prolonged waking causes a homeostatic increase in the need for recovery sleep. Homeostasis is a core component of sleep regulation and has been tightly conserved across evolution from invertebrates to man. Homeostatic sleep regulation was first identified among insects in cockroaches several decades ago, but the characterization of sleep rebound in Drosophila melanogaster opened the use of insect model species to understand homeostatic functions and regulation of sleep. This review describes circuits in two neuropil structures, the central complex and mushroom bodies, that influence sleep homeostasis and neuromodulatory systems that influence the accrual of homeostatic sleep need.
[Mh] Termos MeSH primário: Drosophila melanogaster/fisiologia
Homeostase/fisiologia
Corpos Pedunculados/fisiologia
Sono/fisiologia
[Mh] Termos MeSH secundário: Animais
Neurópilo/fisiologia
Neurotransmissores/metabolismo
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Neurotransmitter Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  10 / 26540 MEDLINE  
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[PMID]:29283227
[Au] Autor:Kolesnikov SS; Bystrova MF
[Ti] Título:Cyclic AMP: Second Messenger as the First Messenger.
[So] Source:Usp Fiziol Nauk;47(3):3-16, 2016 Jul-Sep.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Cell-to-cell communications and autocrine/paracrine regulations are mediated by an extracellular signaling network involving secretion of a variety of different factors, hormones, neurotransmitters, and other signaling molecules that are recognized in an extracellular medium by multiple molecular receptors operating in the plasma membrane of cells. Most of plasma membrane receptors belong to the superfamily of heptahelical receptors, many of which are coupled by G-proteins to adenylate cyclase responsible for cAMP production in the cell cytoplasm. The canonical role of cAMP in cell physiology is to serve as a second messenger and universal regulator of intracellular processes. Meanwhile, increasing body of evidence leaves little doubts that stimulated cells can release cAMP into intercellular space, where it may serve as signaling molecule in cell-to-cell communications and autocrine regulations. This review considers the basic concept on mechanisms of intracellular and extracellular signaling with cAMP as the second and first messenger.
[Mh] Termos MeSH primário: Adenilil Ciclases/metabolismo
AMP Cíclico/metabolismo
Células Eucarióticas/metabolismo
Receptores de Superfície Celular/metabolismo
Sistemas do Segundo Mensageiro/genética
[Mh] Termos MeSH secundário: Adenilil Ciclases/genética
Animais
Comunicação Celular
Membrana Celular/metabolismo
Nucleotídeo Cíclico Fosfodiesterase do Tipo 6/genética
Nucleotídeo Cíclico Fosfodiesterase do Tipo 6/metabolismo
Células Eucarióticas/citologia
Espaço Extracelular/metabolismo
Regulação da Expressão Gênica
Hormônios/genética
Hormônios/metabolismo
Seres Humanos
Neurotransmissores/genética
Neurotransmissores/metabolismo
Receptores de Superfície Celular/genética
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hormones); 0 (Neurotransmitter Agents); 0 (Receptors, Cell Surface); E0399OZS9N (Cyclic AMP); EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 6); EC 4.6.1.1 (Adenylyl Cyclases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE



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