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[PMID]:29279438
[Au] Autor:Ebitani M; Ebitani T
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University.
[Ti] Título:[Rotational Isomers of Diphenhydramine].
[So] Source:Yakugaku Zasshi;138(3):417-424, 2018 Mar 01.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo: Diphenhydramine (DP), an antihistaminic agent, may become colored and daker or more fluorescent during storage. Herein, we spectroscopically examined the causes of this phenomenon under various DP storage conditions and durations. The infrared vibration-rotation spectrum shows multiple Gauche (G)-type conformers with different intramolecular n→π interaction strengths. The splitting pattern of the dimethylamino group protons in the H-NMR spectrum indicates that DP is mainly in the G-type with a small portion in the Trans (T)-type. The correlation between the red-shifted peak intensity in the UV•VIS absorbance spectrum and the coloring progression indicates a decreased intramolecular n→π interaction of the G-type under elevated temperature during storage. Enhanced fluorescence detected in the Excitation•Fluorescence spectrum demonstrates G-type (quenching) to T-type (fluorescent) conformation conversion, which is due to activated internal rotation of the dimethylamino group under elevated storage temperature and electronic excitation in the phenyl groups under light irradiation during storage. A signal detected in the ESR spectrum corresponds to the G-type charge transfer (CT) structure wherein part of the nonbonding electron pair on the N atom is intramolecularly redistributed to the phenyl groups. The CT structure presents the G-type quenching characteristics, whereas weak CT bonding corresponds to coloring. The results indicate that the quenching G-type is converted to T-type by heat or light to become color faded and bright with enhanced fluorescence and that T-type is reverted to G-type after storage under cool and dark conditions or by vacuum distillation to lose fluorescence.
[Mh] Termos MeSH primário: Difenidramina/química
Estabilidade de Medicamentos
Armazenamento de Medicamentos
Antagonistas dos Receptores Histamínicos/química
[Mh] Termos MeSH secundário: Cor
Espectroscopia de Ressonância de Spin Eletrônica
Fluorescência
Isomerismo
Luz
Espectroscopia de Ressonância Magnética
Conformação Molecular
Rotação
Espectrometria de Fluorescência
Espectrofotometria Infravermelho
Análise Espectral
Temperatura Ambiente
Vibração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histamine Antagonists); 8GTS82S83M (Diphenhydramine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00175


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[PMID]:29341563
[Au] Autor:Radonjic V; Jovic I; Kalaba M; Godman B; Kosutic J
[Ti] Título:Consumption of antihistamines in Serbia in the period 2011-2015 and the correlation with adverse drug reaction reports.
[So] Source:Vojnosanit Pregl;73(11):1076-7, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Mh] Termos MeSH primário: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Antagonistas dos Receptores Histamínicos/efeitos adversos
[Mh] Termos MeSH secundário: Sistemas de Notificação de Reações Adversas a Medicamentos
Revisão de Uso de Medicamentos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico
Seres Humanos
Fatores de Risco
Sérvia/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Histamine Antagonists)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP160909242R


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[PMID]:27775976
[Au] Autor:Grey KR; Warshaw EM
[Ad] Endereço:From the *University of Minnesota Medical School; †HCMC Parkside Occupational and Contact Dermatitis Clinic; ‡Department of Dermatology, Minneapolis Veterans Affairs Medical Center; and §Department of Dermatology, University of Minnesota Medical School, Minneapolis.
[Ti] Título:Allergic Contact Dermatitis to Ophthalmic Medications: Relevant Allergens and Alternative Testing Methods.
[So] Source:Dermatitis;27(6):333-347, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Allergic contact dermatitis is an important cause of periorbital dermatitis. Topical ophthalmic agents are relevant sensitizers. Contact dermatitis to ophthalmic medications can be challenging to diagnose and manage given the numerous possible offending agents, including both active and inactive ingredients. Furthermore, a substantial body of literature reports false-negative patch test results to ophthalmic agents. Subsequently, numerous alternative testing methods have been described. This review outlines the periorbital manifestations, causative agents, and alternative testing methods of allergic contact dermatitis to ophthalmic medications.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia
Dermatoses Faciais/etiologia
Lubrificantes Oftálmicos/efeitos adversos
Soluções Oftálmicas/efeitos adversos
[Mh] Termos MeSH secundário: Administração Oftálmica
Agonistas de Receptores Adrenérgicos alfa 1/efeitos adversos
Antagonistas Adrenérgicos beta/efeitos adversos
Antibacterianos/efeitos adversos
Anti-Infecciosos Locais/efeitos adversos
Anti-Inflamatórios/efeitos adversos
Antineoplásicos/efeitos adversos
Antivirais/efeitos adversos
Inibidores da Anidrase Carbônica/efeitos adversos
Antagonistas Colinérgicos/efeitos adversos
Glaucoma/tratamento farmacológico
Antagonistas dos Receptores Histamínicos/efeitos adversos
Seres Humanos
Agonistas Muscarínicos/efeitos adversos
Antagonistas Muscarínicos/efeitos adversos
Prostaglandinas Sintéticas/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenergic alpha-1 Receptor Agonists); 0 (Adrenergic beta-Antagonists); 0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents, Local); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents); 0 (Antiviral Agents); 0 (Carbonic Anhydrase Inhibitors); 0 (Cholinergic Antagonists); 0 (Histamine Antagonists); 0 (Lubricant Eye Drops); 0 (Muscarinic Agonists); 0 (Muscarinic Antagonists); 0 (Ophthalmic Solutions); 0 (Prostaglandins, Synthetic)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29205994
[Au] Autor:Numminen J
[Ti] Título:Allergic rhinitis.
[So] Source:Duodecim;133(5):473-8, 2017.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:There have been no major changes in the pharmacological treatment of allergic rhinitis in recent years. Treatment is symptomatic and tailored individually, taking into account the type and severity of symptoms. Few new products have entered the market, and treatment is still largely based on antihistamines and nasally administered glucocorticoids. However, the general strategies for treating allergic rhinitis have developed over the last decade due to the introduction of the Finnish National Allergy Program. The treatment should aim at improving tolerance. Avoiding allergens is not necessary but it may help in controlling the symptoms. Hyposensitization, the only disease-modifying therapy, is a recommended, effective and safe form of treatment. New, practical sublingual hyposensitization products have facilitated treatment implementation and moved it from outpatient clinics into homes, which is a more patient-oriented approach and also cost-effective in the long term. However, the unit costs of treatment are relatively high for the patients.
[Mh] Termos MeSH primário: Glucocorticoides/uso terapêutico
Antagonistas dos Receptores Histamínicos/uso terapêutico
Rinite Alérgica/tratamento farmacológico
Rinite Alérgica/imunologia
[Mh] Termos MeSH secundário: Dessensibilização Imunológica
Finlândia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Histamine Antagonists)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:29181536
[Au] Autor:Wallace DV; Dykewicz MS; Oppenheimer J; Portnoy JM; Lang DM
[Ad] Endereço:From Nova Southeastern University, Fort Lauderdale, Florida; Saint Louis University School of Medicine, St. Louis, Missouri; Rutgers New Jersey Medical School, Newark, New Jersey; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri; and Cleveland Clinic Foundation, Cleveland
[Ti] Título:Pharmacologic Treatment of Seasonal Allergic Rhinitis: Synopsis of Guidance From the 2017 Joint Task Force on Practice Parameters.
[So] Source:Ann Intern Med;167(12):876-881, 2017 Dec 19.
[Is] ISSN:1539-3704
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Description: The Joint Task Force on Practice Parameters, which comprises representatives of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), formed a workgroup to review evidence and provide guidance to health care providers on the initial pharmacologic treatment of seasonal allergic rhinitis in patients aged 12 years or older. Methods: To update a prior systematic review, the workgroup searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from 18 July 2012 to 29 July 2016 to identify studies that addressed efficacy and adverse effects of single or combination pharmacotherapy for seasonal allergic rhinitis. In conjunction with the Joint Task Force, the workgroup reviewed the evidence and developed recommendations about initial treatment approaches by using the Grading of Recommendations Assessment, Development and Evaluation approach. Members of the AAAAI, the ACAAI, and the general public provided feedback on the draft document, which the Joint Task Force reviewed before finalizing the guideline. Recommendation 1: For initial treatment of seasonal allergic rhinitis in persons aged 12 years or older, routinely prescribe monotherapy with an intranasal corticosteroid rather than an intranasal corticosteroid in combination with an oral antihistamine. (Strong recommendation). Recommendation 2: For initial treatment of seasonal allergic rhinitis in persons aged 15 years or older, recommend an intranasal corticosteroid over a leukotriene receptor antagonist. (Strong recommendation). Recommendation 3: For treatment of moderate to severe seasonal allergic rhinitis in persons aged 12 years or older, the clinician may recommend the combination of an intranasal corticosteroid and an intranasal antihistamine for initial treatment. (Weak recommendation).
[Mh] Termos MeSH primário: Rinite Alérgica Sazonal/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Intranasal
Administração Oral
Adolescente
Corticosteroides/administração & dosagem
Corticosteroides/uso terapêutico
Fatores Etários
Quimioterapia Combinada
Antagonistas dos Receptores Histamínicos/administração & dosagem
Antagonistas dos Receptores Histamínicos/uso terapêutico
Seres Humanos
Antagonistas de Leucotrienos/administração & dosagem
Antagonistas de Leucotrienos/uso terapêutico
Rinite Alérgica Sazonal/diagnóstico
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Histamine Antagonists); 0 (Leukotriene Antagonists)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.7326/M17-2203


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[PMID]:28458431
[Au] Autor:Ali S; Omer MO; Chaudhry MA; Ashraf M; Bukhsh A
[Ad] Endereço:Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, 54000, Punjab, Pakistan.
[Ti] Título:A pharmacological evidence for the presence of antihistaminic and anticholinergic activities in Roxb.
[So] Source:Indian J Pharmacol;49(1):98-101, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The study was designed to evaluate possible antihistaminic and anticholinergic activities of . MATERIALS AND METHODS: Effects of crude ethanolic (Ed.Eth) and effects of crude aqueous (Ed.Aq) extracts of were studied using isolated guinea pig ileum, rabbit jejunum, and rabbit trachea. Tissue responses were recorded using isotonic and isometric transducers, connected with PowerLab data acquisition system. RESULTS: A dose-dependent (0.1-0.3 mg/ml) rightward shift was demonstrated in histamine concentration-response curves. Whereas a complete relaxation of carbachol (1 µM)-induced contractions in isolated rabbit jejunum (3 mg/ml) and tracheal (10 mg/ml) preparations was observed, similar to dicyclomine at 1 and 3 µM, respectively. However, no significant difference between the effects of Ed.Eth and Ed.Aq was observed. CONCLUSION: Study provides pharmacological evidence for the presence of antihistaminic and anticholinergic activities in crude extracts of and also highlight its medicinal significance in the management of airway and gastrointestinal disorders.
[Mh] Termos MeSH primário: Antagonistas Colinérgicos/farmacologia
Equisetum/química
Antagonistas dos Receptores Histamínicos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antagonistas Colinérgicos/administração & dosagem
Antagonistas Colinérgicos/isolamento & purificação
Diciclomina/administração & dosagem
Diciclomina/farmacologia
Relação Dose-Resposta a Droga
Feminino
Cobaias
Antagonistas dos Receptores Histamínicos/administração & dosagem
Íleo/efeitos dos fármacos
Íleo/metabolismo
Jejuno/efeitos dos fármacos
Jejuno/metabolismo
Masculino
Extratos Vegetais/administração & dosagem
Coelhos
Traqueia/efeitos dos fármacos
Traqueia/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinergic Antagonists); 0 (Histamine Antagonists); 0 (Plant Extracts); 4KV4X8IF6V (Dicyclomine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201017


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[PMID]:28458421
[Au] Autor:Saikia B; Barua CC; Haloi P; Patowary P
[Ad] Endereço:Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Guwahati, Assam, India.
[Ti] Título:Anticholinergic, antihistaminic, and antiserotonergic activity of n-hexane extract of seeds on isolated tissue preparations: An study.
[So] Source:Indian J Pharmacol;49(1):42-48, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to evaluate anticholinergic, antihistaminic, and antiserotonergic activity of the n-hexane extract of the seeds of (ZAHE) on isolated ileum of rat and guinea pig and fundus of rat. MATERIALS AND METHODS: ZAHE was prepared using soxhlet extraction and cumulative concentration response curves were constructed using various doses on the tissues for acetylcholine (ACh), 5-hydroxytryptamine (5-HT), and histamine with or without n-hexane extract. Atropine, ketanserin, and pheniramine maleate were used as antagonists for ACh, serotonin, and histamine, respectively. RESULTS: ZAHE-induced concentration-dependent inhibition of isolated ileum and fundus in rat and ileum of guinea pig. The half maximal effective concentration (EC ) of ACh in the presence of atropine (10 M; < 0.05) and ZAHE (1000 µg/ml; < 0.01) was significantly higher than EC of ACh alone. The EC of 5-HT in the presence of ketanserin (10 M; < 0.01) and ZAHE (1000 µg/ml; < 0.05) was higher than EC of 5-HT alone. Similarly, the EC of histamine in the presence of pheniramine maleate (10 M; < 0.01) and ZAHE (300 µg/ml; < 0.01 and 1000 µg/ml; < 0.05) was also significantly higher than EC of histamine alone. CONCLUSION: From the study, it was observed that ZAHE shows significant anticholinergic, antiserotonergic, and antihistaminic activity. The study provides sufficient evidence that the seeds can be used in gastric disorders, cough, chest infection, etc., as per folklore claims.
[Mh] Termos MeSH primário: Antagonistas Colinérgicos/farmacologia
Antagonistas dos Receptores Histamínicos/farmacologia
Extratos Vegetais/farmacologia
Antagonistas da Serotonina/farmacologia
Zanthoxylum/química
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Animais
Antagonistas Colinérgicos/administração & dosagem
Antagonistas Colinérgicos/isolamento & purificação
Relação Dose-Resposta a Droga
Fundo Gástrico/efeitos dos fármacos
Fundo Gástrico/metabolismo
Cobaias
Hexanos/química
Histamina/metabolismo
Antagonistas dos Receptores Histamínicos/administração & dosagem
Antagonistas dos Receptores Histamínicos/isolamento & purificação
Íleo/efeitos dos fármacos
Íleo/metabolismo
Masculino
Extratos Vegetais/administração & dosagem
Ratos
Ratos Wistar
Sementes
Serotonina/metabolismo
Antagonistas da Serotonina/administração & dosagem
Antagonistas da Serotonina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinergic Antagonists); 0 (Hexanes); 0 (Histamine Antagonists); 0 (Plant Extracts); 0 (Serotonin Antagonists); 2DDG612ED8 (n-hexane); 333DO1RDJY (Serotonin); 820484N8I3 (Histamine); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201025


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[PMID]:28939039
[Au] Autor:Wang B; An N; Shaikh AS; Wang H; Xiao L; Liu H; Li J; Zhao D
[Ad] Endereço:Department of Physiology, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, Jinan, China.
[Ti] Título:Hyperosmolarity evokes histamine release from ileum mucosa by stimulating a cholinergic pathway.
[So] Source:Biochem Biophys Res Commun;493(2):1037-1042, 2017 Nov 18.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Changes in extracellular osmolarity lead to alteration in cellular volume. In the study, we examined the effects of hyperosmolarity on short-circuit currents (Isc) in the rat ileum using the Ussing chamber technique. Mucosal exposure to 20 mM glucose evoked a decrease of I in the rat ileum, which was antagonized by the stretch-activated channel blocker GdCl3, TTX and atropine, respectively. In contrast, it was not blocked by phlorizin, a Na -glucose cotransporter SGLT1 inhibitor. Furthermore, the unabsorbed substances, such as sucrose, lactulose or urea, also induced a decrease of I in rat ileum. ELISA results revealed that 20 mM glucose stimulated the release of histamine from rat ileum mucosa, which was attenuated by TTX. In addition, the glucose-induced I was depressed by pyrilamine, a histamine H receptor blocker (H antagonist) whereas it was not affected by ranitidine (H antagonist), clobenpropit (H antagonists) or JNJ7777120 (H antagonist), respectively. The ion substitution experiments suggest that the changes of Na and HCO ion flux underlie the glucose-induced I In conclusion, osmotic stimulus decreased the basal I of rat ileum by evoking histamine release from ileum mucosa. The changes of Na and HCO ion transport are involved in the glucose-evoked decrease of basal I .
[Mh] Termos MeSH primário: Liberação de Histamina
Íleo/fisiologia
Mucosa Intestinal/fisiologia
Pressão Osmótica
[Mh] Termos MeSH secundário: Animais
Bicarbonatos/metabolismo
Tamanho Celular/efeitos dos fármacos
Glucose/metabolismo
Histamina/metabolismo
Antagonistas dos Receptores Histamínicos/farmacologia
Liberação de Histamina/efeitos dos fármacos
Íleo/citologia
Íleo/efeitos dos fármacos
Mucosa Intestinal/efeitos dos fármacos
Transporte de Íons/efeitos dos fármacos
Masculino
Concentração Osmolar
Ratos
Ratos Wistar
Receptores Histamínicos H1/metabolismo
Sódio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Histamine Antagonists); 0 (Receptors, Histamine H1); 820484N8I3 (Histamine); 9NEZ333N27 (Sodium); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170924
[St] Status:MEDLINE


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[PMID]:28866309
[Au] Autor:Hermans MAW; Arends NJT; Gerth van Wijk R; van Hagen PM; Kluin-Nelemans HC; Oude Elberink HNG; Pasmans SGMA; van Daele PLA
[Ad] Endereço:Department of Internal Medicine, Section of Allergy, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Section of Clinical Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: m.hermans@erasmusmc.nl.
[Ti] Título:Management around invasive procedures in mastocytosis: An update.
[So] Source:Ann Allergy Asthma Immunol;119(4):304-309, 2017 Oct.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Mastocytosis is a chronic hematologic disorder that is characterized by the accumulation of aberrant mast cells and typically involves the skin and/or bone marrow. Patients with mastocytosis are at increased risk of anaphylaxis. Based on theoretical assumptions, medical procedures requiring general anesthesia or radiocontrast media are deemed hazardous for patients with mastocytosis. The objective of this article is to provide a comprehensive overview of the actual risk of iatrogenic anaphylaxis and provide recommendations for daily practice. DATA SOURCES: Various scientific search engines were used (eg, PubMed and Medline). STUDY SELECTIONS: Because of the paucity of high-level studies on this topic, all available evidence was considered, including case reports. RESULTS: Reliable data on the incidence of iatrogenic anaphylaxis in mastocytosis are lacking. However, although the incidence as reported in (retrospective) cohort studies is higher than in the general population, it is still lower than commonly anticipated, with an incidence of 5.4% in 1 study. Adequate premedication and avoidance of certain physical stimuli can further decrease this risk by 10-fold. The role of drugs as elicitors of anaphylaxis is perhaps overestimated, and physical stimuli are at least as important in inducing release of mast cell mediators. CONCLUSION: This article provides practical recommendations for the management of invasive procedures in patients with mastocytosis based on current knowledge of this topic.
[Mh] Termos MeSH primário: Anafilaxia/prevenção & controle
Meios de Contraste/efeitos adversos
Mastócitos/patologia
Mastocitose Sistêmica/terapia
Radiografia
[Mh] Termos MeSH secundário: Corticosteroides/efeitos adversos
Anafilaxia/etiologia
Anafilaxia/imunologia
Anafilaxia/patologia
Anestesia Geral/efeitos adversos
Medula Óssea/efeitos dos fármacos
Medula Óssea/imunologia
Medula Óssea/patologia
Contraindicações
Feminino
Antagonistas dos Receptores Histamínicos/efeitos adversos
Seres Humanos
Doença Iatrogênica
Masculino
Mastócitos/efeitos dos fármacos
Mastócitos/imunologia
Mastocitose Sistêmica/diagnóstico por imagem
Mastocitose Sistêmica/imunologia
Mastocitose Sistêmica/patologia
Pele/efeitos dos fármacos
Pele/imunologia
Pele/patologia
Estresse Mecânico
Procedimentos Cirúrgicos Operatórios/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Contrast Media); 0 (Histamine Antagonists)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE


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[PMID]:28766959
[Au] Autor:Beswick DM; Messner AH; Hwang PH
[Ad] Endereço:1 Stanford University School of Medicine, Department of Otolaryngology-Head and Neck Surgery, Stanford, California, USA.
[Ti] Título:Pediatric Chronic Rhinosinusitis Management in Rhinologists and Pediatric Otolaryngologists.
[So] Source:Ann Otol Rhinol Laryngol;126(9):634-639, 2017 Sep.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare the management of pediatric chronic rhinosinusitis (PCRS) between members of the American Rhinologic Society (ARS) and the American Society of Pediatric Otolaryngology (ASPO). STUDY DESIGN: Comparison of surveys. METHODS: A web-based survey was distributed to ASPO membership twice in September-October 2016. Data were compared to previously published data from ARS membership in March-April 2016. RESULTS: ASPO survey completion rate was 22%. ARS members were more likely to employ oral steroids in initial ( P = .025) and maximal medical management ( P = .001). ASPO members more commonly performed adenoidectomy before computed tomography (CT) ( P < .001). Both groups commonly included adenoidectomy as part of initial surgical management (90% vs 94%, P = .316), while ASPO members more frequently performed adenoidectomy alone (70% vs 43%, P = .001). If initial surgical treatment failed, both groups commonly performed endoscopic sinus surgery (ESS; 81% vs 88%, P = .56) with a similar extent including frontal ( P ≥ .207) and sphenoid ( P ≥ .304) surgery. CONCLUSIONS: Pediatric chronic rhinosinusitis management is similar between groups, yet there are differences including oral steroid use, relative order of CT versus adenoidectomy, and performing concomitant procedures with adenoidectomy. Both groups commonly perform ESS with similar surgical extent if prior surgical treatment fails. Management by both groups is largely in agreement with published consensus statements.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Glucocorticoides/uso terapêutico
Antagonistas dos Receptores Histamínicos/uso terapêutico
Otorrinolaringologistas
Procedimentos Cirúrgicos Otorrinolaringológicos/métodos
Pediatras
Rinite/terapia
Sinusite/terapia
[Mh] Termos MeSH secundário: Adenoidectomia/métodos
Adenoidectomia/utilização
Administração Oral
Criança
Doença Crônica
Gerenciamento Clínico
Endoscopia
Seres Humanos
Sprays Nasais
Otolaringologia
Procedimentos Cirúrgicos Otorrinolaringológicos/utilização
Pediatria
Guias de Prática Clínica como Assunto
Padrões de Prática Médica
Rinite/diagnóstico por imagem
Sinusite/diagnóstico por imagem
Sociedades Médicas
Inquéritos e Questionários
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glucocorticoids); 0 (Histamine Antagonists); 0 (Nasal Sprays)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417719717



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