Base de dados : MEDLINE
Pesquisa : D27.505.696.138 [Categoria DeCS]
Referências encontradas : 241 [refinar]
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[PMID]:28910430
[Au] Autor:Rubin R
[Ti] Título:Work Progresses on Male Contraceptives, but Hurdles Remain.
[So] Source:JAMA;318(13):1208-1210, 2017 Oct 03.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anticoncepcionais Masculinos
Descoberta de Drogas
[Mh] Termos MeSH secundário: Animais
Antiespermatogênicos
Anticoncepcionais Masculinos/efeitos adversos
Anticoncepcionais Masculinos/economia
Indústria Farmacêutica
Géis
Seres Humanos
Masculino
Marketing de Serviços de Saúde
National Institute of Child Health and Human Development (U.S.)
Apoio à Pesquisa como Assunto
Estados Unidos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Antispermatogenic Agents); 0 (Contraceptive Agents, Male); 0 (Gels)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.10302


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[PMID]:28230788
[Au] Autor:Ruan Q; Xu Y; Xu R; Wang J; Hua Y; Wang M; Duan J
[Ad] Endereço:Center for Drug Safety Evaluation and Research, Nanjing University of Chinese Medicine, Nanjing 210023, China. ruanql@njucm.edu.cn.
[Ti] Título:The Adverse Effects of Triptolide on the Reproductive System of Caenorhabditis elegans: Oogenesis Impairment and Decreased Oocyte Quality.
[So] Source:Int J Mol Sci;18(2), 2017 Feb 21.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Previous studies have revealed that Triptolide damages female reproductive capacity, but the mechanism is unclear. In this study, we used to investigate the effects of Triptolide on the germline and explore its possible mechanisms. Our data show that exposure for 4 h to 50 and 100 mg/L Triptolide reduced fertility, led to depletion and inactivation of spermatids with the changes in the expression levels of related genes, and increased the number of unfertilized oocytes through damaging chromosomes and DNA damage repair mechanisms. After 24 and 48 h of the 4 h exposure to 50 and 100 mg/L Triptolide, we observed shrink in distal tip cells, an increase in the number of apoptotic cells, a decrease in the number of mitotic germ cells and oocytes in diakinesis stage, and chromatin aggregates in -1 oocytes. Moreover, expression patterns of the genes associated with mitotic germ cell proliferation, apoptosis, and oocyte quality were altered after Triptolide exposure. Therefore, Triptolide may damage fertility of nematodes by hampering the development of oocytes at different developmental stages. Alterations in the expression patterns of genes involved in oocyte development may explain the corresponding changes in oocyte development in nematodes exposed to Triptolide.
[Mh] Termos MeSH primário: Antiespermatogênicos/farmacologia
Caenorhabditis elegans/efeitos dos fármacos
Caenorhabditis elegans/fisiologia
Diterpenos/farmacologia
Fenantrenos/farmacologia
Reprodução/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Compostos de Epóxi/farmacologia
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Masculino
Mitose/efeitos dos fármacos
Oócitos/efeitos dos fármacos
Oócitos/fisiologia
Oogênese/efeitos dos fármacos
Oogênese/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antispermatogenic Agents); 0 (Diterpenes); 0 (Epoxy Compounds); 0 (Phenanthrenes); 19ALD1S53J (triptolide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


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[PMID]:27281446
[Au] Autor:Chinta G; Periyasamy L
[Ad] Endereço:DBT-Interdisciplinary Program in Life Sciences, Pondicherry University, Puducherry, India.
[Ti] Título:Reversible Anti-Spermatogenic Effect of Piperine on Epididymis and Seminal Vesicles of Albino Rats.
[So] Source:Drug Res (Stuttg);66(8):420-6, 2016 Aug.
[Is] ISSN:2194-9387
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We have recently proved the interactions of piperine with androgen receptor and androgen binding protein. The present study was aimed to evaluate the antifertility effect of piperine on male albino rats after the treatment period i. e., after 60 days and withdrawal period i. e., after 120 days. MATERIALS AND METHODS: Adult male rats were divided into 4 groups (n=12). Group I: CONTROL: Rats were given vehicle p.o i. e., 0.5% carboxy methyl cellulose (CMC) in normal saline daily for 60 days, Group II: Rats were treated with piperine suspended in 0.5% CMC at a dose of 10 mg/kg daily/60 days. Group III: Rats were treated with piperine suspended in 0.5% CMC at a dose of 10 mg/kg on every 4(th) day for 60 days. Group IV: Rats were treated with piperine suspended in 0.5% CMC at a dose of 10 mg/kg on every 7(th) day for 60 days. RESULTS: Piperine significantly altered the epididymal sperm count, motility, viability, weight of the epididymis, cauda, caput, corpus and seminal vesicles. It also exhibited negative impact on biochemical markers via decreasing epididymal sialic acid levels, seminal fructose content, epididymal anti-oxidant enzyme activities of super oxide dismutase (SOD), catalase (CAT) and by increasing the malondialdehyde content after the treatment period. Histopathological observations also supported the above findings. All the altered values were reinforced after the withdrawal period. CONCLUSION: From the results of this study, we can conclude that piperine has the potential to become a good lead for the reversible male oral contraceptive research.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Antiespermatogênicos/farmacologia
Benzodioxóis/farmacologia
Epididimo/efeitos dos fármacos
Piperidinas/farmacologia
Alcamidas Poli-Insaturadas/farmacologia
Glândulas Seminais/efeitos dos fármacos
Espermatogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alcaloides/uso terapêutico
Animais
Benzodioxóis/uso terapêutico
Epididimo/ultraestrutura
Masculino
Tamanho do Órgão/efeitos dos fármacos
Piperidinas/uso terapêutico
Alcamidas Poli-Insaturadas/uso terapêutico
Ratos
Glândulas Seminais/ultraestrutura
Contagem de Espermatozoides
Motilidade Espermática
Espermatozoides/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antispermatogenic Agents); 0 (Benzodioxoles); 0 (Piperidines); 0 (Polyunsaturated Alkamides); U71XL721QK (piperine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-108186


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[PMID]:27266032
[Au] Autor:Lovinskaya AV; Kolumbayeva SZh; Abilev SK; Kolomiets OL
[Ti] Título:[IMMUNOCYTOCHEMICAL ANALYSIS OF THE DISTURBANCES IN THE STRUCTURE OF SYNAPTONEMAL COMPLEXES IN SPERMATOCYTE NUCLEI IN MICE UNDER EXPOSURE TO ROCKET FUEL COMPONENT].
[So] Source:Gig Sanit;95(3):293-6, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There was performed an assessment of genotoxic effects of rocket fuel component--unsymmetrical dimethylhydrazine (UDMH, heptyl)--on forming germ cells of male mice. Immunocytochemically there was studied the structure of meiotic nuclei at different times after the intraperitoneal administration of UDMH to male mice. There were revealed following types of disturbances of the structure of synaptonemal complexes (SCs) of meiotic chromosomes: single and multiple fragments of SCs associations of autosomes with a sex bivalent, atypical structure of the SCs with a frequency higher than the reference level. In addition, there were found the premature desinapsis of sex bivalents, the disorder offormation of the genital corpuscle and ring SCs. Established disorders in SCs of spermatocytes, analyzed at 38th day after the 10-days intoxication of animal by the component of rocket fuel, attest to the risk of permanent persistence of chromosomal abnormalities occurring in the pool of stem cells.
[Mh] Termos MeSH primário: Aberrações Cromossômicas/induzido quimicamente
Dimetilidrazinas
Gasolina/toxicidade
Espermatócitos
Complexo Sinaptonêmico
[Mh] Termos MeSH secundário: Animais
Antiespermatogênicos/administração & dosagem
Antiespermatogênicos/química
Antiespermatogênicos/toxicidade
Dimetilidrazinas/administração & dosagem
Dimetilidrazinas/química
Dimetilidrazinas/toxicidade
Imuno-Histoquímica/métodos
Infecções Intra-Abdominais
Masculino
Camundongos
Modelos Animais
Maturação do Esperma/efeitos dos fármacos
Espermatócitos/efeitos dos fármacos
Espermatócitos/fisiologia
Complexo Sinaptonêmico/efeitos dos fármacos
Complexo Sinaptonêmico/genética
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antispermatogenic Agents); 0 (Dimethylhydrazines); 0 (Gasoline); 4WPQ90N53J (dimazine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160607
[Lr] Data última revisão:
160607
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE


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[PMID]:27016468
[Au] Autor:Chao JH; Page ST
[Ad] Endereço:Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA.
[Ti] Título:The current state of male hormonal contraception.
[So] Source:Pharmacol Ther;163:109-17, 2016 Jul.
[Is] ISSN:1879-016X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:World population continues to grow at an unprecedented rate, doubling in a mere 50years to surpass the 7-billion milestone in 2011. This steep population growth exerts enormous pressure on the global environment. Despite the availability of numerous contraceptive choices for women, approximately half of all pregnancies are unintended and at least half of those are unwanted. Such statistics suggest that there is still a gap in contraceptive options for couples, particularly effective reversible contraceptives for men, who have few contraceptive choices. Male hormonal contraception has been an active area of research for almost 50years. The fundamental concept involves the use of exogenous hormones to suppress endogenous production of gonadotropins, testosterone, and downstream spermatogenesis. Testosterone-alone regimens are effective in many men but high dosing requirements and sub-optimal gonadotropin suppression in 10-30% of men limit their use. A number of novel combinations of testosterone and progestins have been shown to be more efficacious but still require further refinement in delivery systems and a clearer understanding of the potential short- and long-term side effects. Recently, synthetic androgens with both androgenic and progestogenic activity have been developed. These agents have the potential to be single-agent male hormonal contraceptives. Early studies of these compounds are encouraging and there is reason for optimism that these may provide safe, reversible, and reliable contraception for men in the near future.
[Mh] Termos MeSH primário: Antiespermatogênicos/farmacologia
Antiespermatogênicos/uso terapêutico
Progestinas/farmacologia
Progestinas/uso terapêutico
Testosterona/farmacologia
[Mh] Termos MeSH secundário: Androgênios/farmacologia
Antiespermatogênicos/administração & dosagem
Antiespermatogênicos/efeitos adversos
Acetato de Ciproterona/uso terapêutico
Vias de Administração de Medicamentos
Quimioterapia Combinada
Hormônio Foliculoestimulante/metabolismo
Hormônio Liberador de Gonadotropina/antagonistas & inibidores
Gonadotropinas/metabolismo
Seres Humanos
Hormônio Luteinizante/metabolismo
Masculino
Progestinas/administração & dosagem
Progestinas/efeitos adversos
Espermatogênese/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Androgens); 0 (Antispermatogenic Agents); 0 (Gonadotropins); 0 (Progestins); 33515-09-2 (Gonadotropin-Releasing Hormone); 3XMK78S47O (Testosterone); 4KM2BN5JHF (Cyproterone Acetate); 9002-67-9 (Luteinizing Hormone); 9002-68-0 (Follicle Stimulating Hormone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160327
[St] Status:MEDLINE


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[PMID]:26732151
[Au] Autor:Kanakis GA; Goulis DG
[Ad] Endereço:Department of Endocrinology, Athens Naval & VA Hospital, Athens, Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki; Greece.
[Ti] Título:Male contraception: a clinically-oriented review.
[So] Source:Hormones (Athens);14(4):598-614, 2015 Oct-Dec.
[Is] ISSN:1109-3099
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Despite the variety of available female contraceptive methods, many pregnancies (~50%) are still undesired. Many men (>60%) want to participate equally with their partner in family planning; however, male contraceptive methods (MCMs) account for only 14% of those used worldwide and no pharmaceutical MCM is available so far. The only two MCMs currently available are condoms, which despite protecting against sexually transmitted diseases have high failure rates (~19%), and vasectomy, which though very efficient (99%) is poorly reversible (<50%). Among MCMs under investigation, male hormonal contraceptives (MHCs) are those that have come closest to commercialization. The action of MHCs relies on the disruption of spermatogenesis that exogenous androgen administration evokes by suppressing the hypophyseal-gonadal axis. Various regimens of androgens as monotherapy or in combination with progestins have been tested in clinical trials achieving a Pearl Index <1.0 (equal to that of the female oral contraceptive pill); however, concerns regarding the variable response rates observed (non-responders: 5-20%), the impracticality of parenteral administration and long-term prostate-associated or cardiovascular morbidity have deflected the interest of the pharmaceutical industry from further research. Non-hormonal contraception methods may be, at least theoretically, more specific by selectively disrupting spermatogenesis and sperm transport or fertilizing ability. Nevertheless, only a few have been tested in clinical trials (Reversible Inhibition of Sperm Under Guidance, RISUG, and Intra Vas Plugs); most of them are still in pre-clinical development or have been abandoned due to toxicity (gossypol). Consequently, until a reliable, safe and practical MCM is developed, women will continue to bear most of the contraception burden.
[Mh] Termos MeSH primário: Androgênios/uso terapêutico
Antiespermatogênicos/uso terapêutico
Anticoncepção/métodos
Sistema Hipotálamo-Hipofisário/efeitos dos fármacos
Espermatogênese/efeitos dos fármacos
Testículo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Androgênios/efeitos adversos
Antiespermatogênicos/efeitos adversos
Preservativos
Anticoncepção/efeitos adversos
Combinação de Medicamentos
Feminino
Seres Humanos
Sistema Hipotálamo-Hipofisário/metabolismo
Masculino
Gravidez
Testículo/metabolismo
Vasectomia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Androgens); 0 (Antispermatogenic Agents); 0 (Drug Combinations)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160107
[St] Status:MEDLINE
[do] DOI:10.14310/horm.2002.1623


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[PMID]:26274532
[Au] Autor:Briz V; Sepúlveda-Crespo D; Diniz AR; Borrego P; Rodes B; de la Mata FJ; Gómez R; Taveira N; Muñoz-Fernández MÁ
[Ad] Endereço:Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
[Ti] Título:Development of water-soluble polyanionic carbosilane dendrimers as novel and highly potent topical anti-HIV-2 microbicides.
[So] Source:Nanoscale;7(35):14669-83, 2015 Sep 21.
[Is] ISSN:2040-3372
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The development of topical microbicide formulations for vaginal delivery to prevent HIV-2 sexual transmission is urgently needed. Second- and third-generation polyanionic carbosilane dendrimers with a silicon atom core and 16 sulfonate (G2-S16), napthylsulfonate (G2-NS16) and sulphate (G3-Sh16) end-groups have shown potent and broad-spectrum anti-HIV-1 activity. However, their antiviral activity against HIV-2 and mode of action have not been probed. Cytotoxicity, anti-HIV-2, anti-sperm and antimicrobial activities of dendrimers were determined. Analysis of combined effects of triple combinations with tenofovir and raltegravir was performed by using CalcuSyn software. We also assessed the mode of antiviral action on the inhibition of HIV-2 infection through a panel of different in vitro antiviral assays: attachment, internalization in PBMCs, inactivation and cell-based fusion. Vaginal irritation and histological analysis in female BALB/c mice were evaluated. Our results suggest that G2-S16, G2-NS16 and G3-Sh16 exert anti-HIV-2 activity at an early stage of viral replication inactivating the virus, inhibiting cell-to-cell HIV-2 transmission, and blocking the binding of gp120 to CD4, and the HIV-2 entry. Triple combinations with tenofovir and raltegravir increased the anti-HIV-2 activity, consistent with synergistic interactions (CIwt: 0.33-0.66). No vaginal irritation was detected in BALB/c mice after two consecutive applications for 2 days with 3% G2-S16. Our results have clearly shown that G2-S16, G2-NS16 and G3-Sh16 have high potency against HIV-2 infection. The modes of action confirm their multifactorial and non-specific ability, suggesting that these dendrimers deserve further studies as potential candidate microbicides to prevent vaginal/rectal HIV-1/HIV-2 transmission in humans.
[Mh] Termos MeSH primário: Antiespermatogênicos
Antivirais
Dendrímeros
Infecções por HIV/prevenção & controle
HIV-2/fisiologia
Silanos
Replicação Viral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Antiespermatogênicos/síntese química
Antiespermatogênicos/química
Antiespermatogênicos/farmacologia
Antivirais/síntese química
Antivirais/química
Antivirais/farmacologia
Dendrímeros/síntese química
Dendrímeros/química
Dendrímeros/farmacologia
Feminino
Seres Humanos
Leucócitos Mononucleares/virologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Silanos/síntese química
Silanos/química
Silanos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antispermatogenic Agents); 0 (Antiviral Agents); 0 (Dendrimers); 0 (Silanes); 0 (carbosilane)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:150828
[Lr] Data última revisão:
150828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150815
[St] Status:MEDLINE
[do] DOI:10.1039/c5nr03644e


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[PMID]:25337835
[Au] Autor:Zhang YF; Yuan KM; Liang Y; Chu YH; Lian QQ; Ge YF; Zhen W; Sottas CM; Su ZJ; Ge RS
[Ti] Título:Alterations of gene profiles in Leydig-cell-regenerating adult rat testis after ethane dimethane sulfonate-treatment.
[So] Source:Asian J Androl;17(2):253-60, 2015 Mar-Apr.
[Is] ISSN:1745-7262
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Only occupying about 1%-5% of total testicular cells, the adult Leydig cell (ALC) is a unique endocrine cell that produces androgens. Rat Leydig cells regenerate after these cells in the testis are eliminated with ethane dimethane sulfonate (EDS). In this study, we have characterized Leydig cell regeneration and messenger ribonucleic acids (mRNA) profiles of EDS treated rat testes. Serum testosterone, testicular gene profiling and some steroidogenesis-related proteins were analyzed at 7, 21, 35 and 90 days after EDS treatment. Testicular testosterone levels declined to undetectable levels until 7 days after treatment and then started to recover. Seven days after treatment, 81 mRNAs were down-regulated greater than or equal to two-fold, with 48 becoming undetectable. These genes increased their expression 21 days and completely returned to normal levels 90 days after treatment. The undetectable genes include steroidogenic pathway proteins: steroidogenic acute regulatory protein, Scarb1, Cyp11a1, Cyp17a1, Hsd3b1, Cyp1b1 and Cyp2a1. Seven days after treatment, there were 89 mRNAs up-regulated two-fold or more including Pkib. These up-regulated mRNAs returned to normal 90 days after treatment. Cyp2a1 did not start to recover until 35 days after treatment, indicating that this gene is only expressed in ALCs not in the precursor cells. Quantitative polymerase chain reaction, western blotting and semi-quantitative immunohistochemical staining using tissue array confirmed the changes of several randomly picked genes and their proteins.
[Mh] Termos MeSH primário: Antiespermatogênicos/farmacologia
Perfilação da Expressão Gênica
Regulação da Expressão Gênica/efeitos dos fármacos
Células Intersticiais do Testículo/metabolismo
Mesilatos/farmacologia
Regeneração/efeitos dos fármacos
Testículo/metabolismo
[Mh] Termos MeSH secundário: Animais
Hidrocarboneto de Aril Hidroxilases/genética
Hidrocarboneto de Aril Hidroxilases/metabolismo
Família 2 do Citocromo P450
Regulação da Expressão Gênica/fisiologia
Peptídeos e Proteínas de Sinalização Intracelular/genética
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo
Células Intersticiais do Testículo/citologia
Células Intersticiais do Testículo/efeitos dos fármacos
Masculino
Análise em Microsséries
Modelos Animais
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
Ratos Sprague-Dawley
Regeneração/fisiologia
Esteroide Hidroxilases/genética
Esteroide Hidroxilases/metabolismo
Testículo/citologia
Testículo/efeitos dos fármacos
Testosterona/genética
Testosterona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antispermatogenic Agents); 0 (Intracellular Signaling Peptides and Proteins); 0 (Mesylates); 0 (Pkib protein, rat); 0 (RNA, Messenger); 3XMK78S47O (Testosterone); EC 1.14.- (Steroid Hydroxylases); EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases); EC 1.14.14.1 (Cyp2a1 protein, rat); EC 1.14.14.1 (Cytochrome P450 Family 2); EW8V7BJ66Q (ethylene dimethanesulfonate)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141023
[St] Status:MEDLINE
[do] DOI:10.4103/1008-682X.136447


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[PMID]:25658225
[Au] Autor:Payne C; Goldberg E
[Ti] Título:Male contraception: past, present and future.
[So] Source:Curr Mol Pharmacol;7(2):175-81, 2014.
[Is] ISSN:1874-4702
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:Current contraceptive options available to men include withdrawal, condoms, and vasectomy, each of which has its own drawbacks. In this chapter we will describe the pros and cons for each, as well as methodological and product updates. Statistics from the U.S. Centers for Disease Control on acceptance and satisfaction will be included. Advances in vasectomy and reversal will be presented. Methods to develop new contraceptive technologies fall into two categories: hormonal and non-hormonal. Many targets and strategies have been proposed for non-hormonal male contraception within the testis. Targets include structural components in the testis, as well as enzymes, ion channels and other proteins specific to spermatozoa. Here we provide an overview of the spermatogenic mechanisms and proteins that have received research interest to date. We also discuss potential novel targets, such as ubiquitin specific proteases, that warrant greater research emphasis.
[Mh] Termos MeSH primário: Antiespermatogênicos/uso terapêutico
Anticoncepção
Descoberta de Drogas
Fertilidade/efeitos dos fármacos
Espermatogênese/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
Testículo/efeitos dos fármacos
Vasectomia
[Mh] Termos MeSH secundário: Animais
Antiespermatogênicos/efeitos adversos
Antiespermatogênicos/história
Anticoncepção/efeitos adversos
Anticoncepção/história
Anticoncepção/tendências
Difusão de Inovações
Descoberta de Drogas/história
Descoberta de Drogas/tendências
História do Século XX
História do Século XXI
Seres Humanos
Masculino
Terapia de Alvo Molecular
Espermatozoides/metabolismo
Testículo/metabolismo
Vasectomia/efeitos adversos
Vasectomia/história
Vasectomia/tendências
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antispermatogenic Agents)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150303
[Lr] Data última revisão:
150303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150207
[St] Status:MEDLINE


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[PMID]:25620231
[Au] Autor:Oliveira PF; Alves MG
[Ti] Título:Targeting mammalian spermatogenesis: a matter of support.
[So] Source:Curr Mol Pharmacol;7(2):81-2, 2014.
[Is] ISSN:1874-4702
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Mh] Termos MeSH primário: Antiespermatogênicos/uso terapêutico
Fertilidade/efeitos dos fármacos
Espermatogênese/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
Testículo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Desenho de Drogas
Seres Humanos
Masculino
Terapia de Alvo Molecular
Espermatozoides/metabolismo
Testículo/metabolismo
[Pt] Tipo de publicação:EDITORIAL; INTRODUCTORY JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antispermatogenic Agents)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150303
[Lr] Data última revisão:
150303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150127
[St] Status:MEDLINE



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