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  1 / 2063 MEDLINE  
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[PMID]:28857520
[Au] Autor:Zupcic M; Graf Zupcic S; Duzel V; Simurina T; Sakic L; Fuduric J; Persec J; Milosevic M; Stanec Z; Korusic A; Barisin S
[Ad] Endereço:Miroslav Zupcic, Anesthesiology, Reanimatology and Intensive Care Medicine, Clinical Hospital Dubrava, Av. G. Suska 6, 10000 Zagreb, Croatia, miro_zupcic@yahoo.com.
[Ti] Título:A combination of levobupivacaine and lidocaine for paravertebral block in breast cancer patients undergoing quadrantectomy causes greater hemodynamic oscillations than levobupivacaine alone.
[So] Source:Croat Med J;58(4):270-280, 2017 Aug 31.
[Is] ISSN:1332-8166
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:AIM: To test for differences in hemodynamic and analgesic properties in patients with breast cancer undergoing quadrantectomy with paravertebral block (PVB) induced with a solution of either one or two local anesthetics. METHOD: A prospective, single-center, randomized, double-blinded, controlled trial was conducted from June 2014 until September 2015. A total of 85 women with breast cancer were assigned to receive PVB with either 0.5% levobupivacaine (n=42) or 0.5% levobupivacaine with 2% lidocaine (n=43). Hemodynamic variables of interest included intraoperative stroke volume variation (SVV), mean arterial pressure, heart rate, cardiac output, episodes of hypotension, use of crystalloids, and use of inotropes. Analgesic variables of interest were time to block onset, duration of analgesia, and postoperative serial pain assessment using a visual analogue scale. RESULTS: Although the use of 0.5% levobupivacaine with 2% lidocaine solution for PVB decreased the mean time-to-block onset (14 minutes; P<0.001), it also caused significantly higher SVV values over the 60 minutes of monitoring (mean difference: 4.33; P<0.001). Furthermore, the patients who received 0.5% levobupivacaine with 2% lidocaine experienced shorter mean duration of analgesia (105 minutes; P=0.006) and more episodes of hypotension (17.5%; P=0.048) and received more intraoperative crystalloids (mean volume: 550 mL; P<0.001). CONCLUSION: The use of 0.5% levobupivacaine in comparison with 0.5% levobupivacaine with 2% lidocaine solution for PVB had a longer time-to-block onset, but it also reduced hemodynamic disturbances and prolonged the analgesic effect.
[Mh] Termos MeSH primário: Anestésicos Combinados
Anestésicos Locais
Neoplasias da Mama/cirurgia
Bupivacaína/análogos & derivados
Hemodinâmica/efeitos dos fármacos
Lidocaína
[Mh] Termos MeSH secundário: Idoso
Analgesia
Neoplasias da Mama/fisiopatologia
Método Duplo-Cego
Feminino
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Meia-Idade
Bloqueio Nervoso
Medição da Dor
Dor Pós-Operatória/tratamento farmacológico
Dor Pós-Operatória/fisiopatologia
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Anesthetics, Local); 98PI200987 (Lidocaine); A5H73K9U3W (levobupivacaine); Y8335394RO (Bupivacaine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE


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[PMID]:28822974
[Au] Autor:Medeiros LQ; Gozalo-Marcilla M; Taylor PM; Campagnol D; de Oliveira FA; Watanabe MJ; de Araujo Aguiar AJ
[Ad] Endereço:Graduate Program in Anaesthesiology, Medical School of Botucatu, UNESP-Univ Estadual Paulista, Botucatu-SP, Brazil.
[Ti] Título:Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses.
[So] Source:Vet Rec;181(15):402, 2017 Oct 14.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dexmedetomidine (DEX) alone, or combined with butorphanol (BUT), may be administered by constant rate infusions (CRIs) in standing horses. This blinded, randomised, crossover study in six healthy adult horses aimed to determine the sedative and cardiopulmonary effects of DEX (dexmedetomidine (3.5 µg/kg+5 µg/kg/hour CRI) and DEX/BUT (dexmedetomidine (3.5 µg/kg+3.5 µg/kg/hour CRI) and butorphanol (20 µg/kg+24 µg/kg/hour CRI)). Head height above ground (HHAG), ataxia, responses to tactile/auditory stimuli and cardiopulmonary variables were recorded before, at 5/15/30/60/90 minutes and after CRIs terminated (15/30/60 minutes). Repeated measures analysis of variance with Tukey-Kramer test were used for cardiopulmonary values (mean±SD) and HHAG reduction (per cent), and Friedman's and Dunn's for non-parametric data (P<0.05). Maximum HHAG reductions of 54 per cent (DEX) and 58 per cent (DEX/BUT) occurred at 15 minutes, with ataxia for 15 minutes in both treatments. Responses to stimuli were reduced for 30 minutes in both treatments, and auditory up to 60 minutes in DEX. Cardiopulmonary effects typical of α -agonists were observed, with no differences between treatments. At the doses and rates reported here, both regimens provided clinically sufficient sedation for only 30 minutes.
[Mh] Termos MeSH primário: Analgésicos Opioides/farmacologia
Anestésicos Combinados/farmacologia
Butorfanol/farmacologia
Sistema Cardiovascular/efeitos dos fármacos
Dexmedetomidina/farmacologia
Hipnóticos e Sedativos/farmacologia
Sistema Respiratório/efeitos dos fármacos
[Mh] Termos MeSH secundário: Analgésicos Opioides/administração & dosagem
Anestésicos Combinados/administração & dosagem
Animais
Butorfanol/administração & dosagem
Estudos Cross-Over
Dexmedetomidina/administração & dosagem
Feminino
Cavalos
Hipnóticos e Sedativos/administração & dosagem
Infusões Intravenosas/métodos
Infusões Intravenosas/veterinária
Masculino
Postura
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Anesthetics, Combined); 0 (Hypnotics and Sedatives); 67VB76HONO (Dexmedetomidine); QV897JC36D (Butorphanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170821
[St] Status:MEDLINE
[do] DOI:10.1136/vr.104359


  3 / 2063 MEDLINE  
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[PMID]:28437508
[Au] Autor:Aggarwal V; Singla M; Miglani S
[Ti] Título:Comparative Evaluation of Anesthetic Efficacy of 2% Lidocaine, 4% Articaine, and 0.5% Bupivacaine on Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double-blind Clinical Trial.
[So] Source:J Oral Facial Pain Headache;31(2):124-128, 2017 Spring.
[Is] ISSN:2333-0384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: To compare the anesthetic efficacy of 1.8 mL of 2% lidocaine with 1:200,000 epinephrine, 4% articaine with 1:100,000 epinephrine, and 0.5% bupivacaine with 1:200,000 epinephrine on producing inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis. METHODS: A total of 91 adult patients who were actively experiencing mandibular molar pain were involved in this study. The patients were randomly divided into three groups on the basis of the anesthetic solution used. The first group received IANB with 1.8 mL of 2% lidocaine with 1:200,000 epinephrine, the second group received IANB with 4% articaine with 1:100,000 epinephrine, and the third group received IANB with 0.5% bupivacaine with 1:200,000 epinephrine. After 15 minutes of IANB, conventional endodontic access preparation was started. The pain during the treatment was noted on a Heft-Parker visual analog scale (HP VAS). The primary outcome measure was anesthetic success, and anesthesia was considered successful if the patient reported no pain or weak/mild pain (HP VAS score < 55 mm) during endodontic treatment (pulp access and canal preparation procedures). The data were analyzed with one-way analysis of variance and chi-square test. RESULTS: The anesthetic success rates of 2% lidocaine, 4% articaine, and 0.5% bupivacaine were 23%, 33%, and 17%, respectively. The differences were statistically insignificant (P > .05). CONCLUSION: The 2% lidocaine solution used for IANB had similar success rates when compared with 4% articaine and 0.5% bupivacaine.
[Mh] Termos MeSH primário: Anestésicos Combinados/administração & dosagem
Anestésicos Locais/administração & dosagem
Bupivacaína/administração & dosagem
Carticaína/administração & dosagem
Epinefrina/administração & dosagem
Lidocaína/administração & dosagem
Nervo Mandibular/efeitos dos fármacos
Bloqueio Nervoso
Pulpite
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Anesthetics, Local); 98PI200987 (Lidocaine); D3SQ406G9X (Carticaine); Y8335394RO (Bupivacaine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.11607/ofph.1642


  4 / 2063 MEDLINE  
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[PMID]:28328950
[Au] Autor:Schmitz S; Tacke S; Guth B; Henke J
[Ad] Endereço:Department of Nonclinical Drug Safety, Biological Laboratory Service, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
[Ti] Título:Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters.
[So] Source:PLoS One;12(3):e0174423, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Repeated anaesthesia may be required in experimental protocols and in daily veterinary practice, but anaesthesia is known to alter physiological parameters in GPs (Cavia porcellus, GPs). This study investigated the effects of repeated anaesthesia with either medetomidine-midazolam-fentanyl (MMF) or isoflurane (Iso) on physiological parameters in the GP. Twelve GPs were repeatedly administered with MMF or Iso in two anaesthesia sets. One set consisted of six 40-min anaesthesias, performed over 3 weeks (2 per week); the anaesthetic used first was randomized. Prior to Iso anaesthesia, atropine was injected. MMF anaesthesia was antagonized with AFN (atipamezole-flumazenil-naloxone). Abdominally implanted radio-telemetry devices recorded the mean arterial blood pressure (MAP), heart rate (HR) and core body temperature continuously. Additionally, respiratory rate, blood glucose and body weight were assessed. An operable state could be achieved and maintained for 40 min in all GPs. During the surgical tolerance with MMF, the GPs showed a large MAP range between the individuals. In the MMF wake- up phase, the time was shortened until the righting reflex (RR) returned and that occurred at lower MAP and HR values. Repeated Iso anaesthesia led to an increasing HR during induction (anaesthesias 2-6), non-surgical tolerance (anaesthesias 3-6) and surgical tolerance (anaesthesias 4, 6). Both anaesthetics may be used repeatedly, as repeating the anaesthesias resulted in only slightly different physiological parameters, compared to those seen with single anaesthesias. The regular atropine premedication induced HR increases and repeated MMF anaesthesia resulted in a metabolism increase which led to the faster return of RR. Nevertheless, Iso's anaesthesia effects of strong respiratory depression and severe hypotension remained. Based on this increased anaesthesia risk with Iso, MMF anaesthesia is preferable for repeated use in GPs.
[Mh] Termos MeSH primário: Fentanila/administração & dosagem
Isoflurano/administração & dosagem
Medetomidina/administração & dosagem
Midazolam/administração & dosagem
Fenômenos Fisiológicos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anestesia/métodos
Anestésicos Combinados/administração & dosagem
Animais
Glicemia/efeitos dos fármacos
Pressão Sanguínea/efeitos dos fármacos
Cobaias
Frequência Cardíaca/efeitos dos fármacos
Masculino
Taxa Respiratória/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Blood Glucose); CYS9AKD70P (Isoflurane); MR15E85MQM (Medetomidine); R60L0SM5BC (Midazolam); UF599785JZ (Fentanyl)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174423


  5 / 2063 MEDLINE  
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[PMID]:28237652
[Au] Autor:Kuroda H; Kawamura G; Soya M; Kitamura T; Ichinohe T; Yamada Y
[Ad] Endereço:Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan. Electronic address: kurodahidetaka@tdc.ac.jp.
[Ti] Título:Impact of Epinephrine Contained in Local Anesthetic Solution on Serum Lactate Level During Orthognathic Surgery.
[So] Source:J Oral Maxillofac Surg;75(8):1637-1642, 2017 Aug.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: There have been many discussions of a relation between endogenous and exogenous epinephrine and hyperlactatemia. This study aimed to identify the impact of epinephrine contained in a local anesthetic solution on serum lactate levels in patients who underwent orthognathic surgery. MATERIALS AND METHODS: This study was a retrospective record review of cases of maxillary and mandibular osteotomy at the Tokyo University Hospital (Tokyo, Japan) from January 2006 through December 2014. One hundred ninety-three patients were enrolled in this study. RESULTS: The maximum intraoperative serum lactate level was 22.3 ± 14.7 mg/dL. Of 193 patients, 91 showed an intraoperative serum lactate level that was higher than the normal maximum of 19.8 mg/dL (2.2 mmol/L), and 16 of these had a level that was at least 40 mg/dL (≥4.49 mmol/L). Multiple logistic regression analysis showed 2 factors that could increase the serum lactate level: the amount of epinephrine contained in the local anesthetic solution injected into the oral cavity (odds ratio [OR] = 1.014; 95% confidence interval [CI], 1.006-1.022; P = .0001) and the absence of intraoperative treatment with propranolol (OR, 0.105; 95% CI, 0.019-0.434; P = .0013). Patients with severe serum lactate concentrations (ie, ≥40 mg/dL [≥4.49 mmol/L]) had slight metabolic acidosis. All patients survived 90 days. The number of postoperative hospitalization days for patients with severe serum lactate concentrations was 12.8 ± 2.6 days and that for patients without severe serum lactate concentration was 16.0 ± 8.6 days. CONCLUSION: Increases in intraoperative serum lactate levels during orthognathic surgery are associated, at least in part, with increased aerobic glycolysis because of ß -adrenergic signaling. Lactate increase caused by epinephrine contained in a local anesthetic solution does not result in a poor postoperative outcome.
[Mh] Termos MeSH primário: Anestésicos Combinados/administração & dosagem
Anestésicos Combinados/efeitos adversos
Anestésicos Locais/administração & dosagem
Anestésicos Locais/efeitos adversos
Epinefrina/administração & dosagem
Epinefrina/efeitos adversos
Hiperlactatemia/induzido quimicamente
Complicações Intraoperatórias/induzido quimicamente
Ácido Láctico/sangue
Osteotomia Mandibular
Osteotomia Maxilar
Procedimentos Cirúrgicos Ortognáticos/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hiperlactatemia/sangue
Complicações Intraoperatórias/sangue
Japão
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Anesthetics, Local); 33X04XA5AT (Lactic Acid); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


  6 / 2063 MEDLINE  
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[PMID]:28174153
[Au] Autor:Zhou YL; Tong Y; Wang YX; Zhao PQ; Wang ZY
[Ad] Endereço:Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
[Ti] Título:A prospective, randomised, double-masked comparison of local anaesthetic agents for vitrectomy.
[So] Source:Br J Ophthalmol;101(8):1016-1021, 2017 Aug.
[Is] ISSN:1468-2079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the intraoperative and postoperative clinical properties of 1% ropivacaine, 0.75% bupivacaine, 2% lidocaine and a mixture of 0.75% bupivacaine and 2% lidocaine (bupi+lido) administered for peribulbar anaesthesia during vitrectomy. METHODS: A total of 140 patients were randomly allocated to four groups. The time of onset of analgesia and akinesia was measured. The efficacy of anaesthesia, degree of postoperative pain and intraoperative and postoperative complications were recorded. RESULTS: The mean times of onset (±SD) of analgesia for the ropivacaine, bupivacaine, lidocaine and lido+bupi groups were 90.46±30.08, 94.83±40.72, 78.31±12.56 and 101.51±56.94 s, respectively (p=0.087). The mean times of onset (±SD) of akinesia for the ropivacaine, bupivacaine, lidocaine and lido+bupi groups were 138.89±62.65, 151.86±84.78, 122.66±49.35 and 141.54±62.69 s, respectively (p=0.323). No significant difference was observed in the number of patients who attained grade-5 anaesthesia in the four groups (p=0.966). The outcome of ordered logit analysis showed that the 1% ropivacaine resulted in a significantly lower degree of postoperative pain compared with the other three groups (p=0.017, p=0.001 and p=0.001, respectively). The incidence of postoperative subconjunctival haemorrhage was decreased in the ropivacaine group compared with the other three groups (p<0.001). CONCLUSIONS: For peribulbar anaesthesia in vitrectomy, 1% ropivacaine alone provides an adequate intraoperative anaesthesia similar to that provided by the bupivacaine, lidocaine and lido+bupi solutions, as well as provides a better quality of postoperative analgesia and decreases postoperative subconjunctival haemorrhage. TRIAL REGISTRATION NUMBER: ChiCTR-IPR-16007876; Results.
[Mh] Termos MeSH primário: Anestésicos Locais
Bloqueio Nervoso/métodos
Doenças Retinianas/cirurgia
Vitrectomia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Amidas
Anestésicos Combinados
Bupivacaína
Método Duplo-Cego
Feminino
Seres Humanos
Lidocaína
Masculino
Meia-Idade
Dor Pós-Operatória/etiologia
Dor Pós-Operatória/prevenção & controle
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Amides); 0 (Anesthetics, Combined); 0 (Anesthetics, Local); 7IO5LYA57N (ropivacaine); 98PI200987 (Lidocaine); Y8335394RO (Bupivacaine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1136/bjophthalmol-2016-309780


  7 / 2063 MEDLINE  
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[PMID]:28017546
[Au] Autor:Ensat F; Heinrich K; Kholosy HM; Wimbauer J; Hladik M; Wechselberger G
[Ad] Endereço:Department of Plastic and Reconstructive Surgery, Hospital of the Barmherzigen Brüder, Teaching hospital of the Paracelsus Medical University Salzburg, Kajetanerplatz 1, 5020 Salzburg, Austria.
[Ti] Título:A double-blind randomized prospective study comparing prilocaine versus ropivacaine in upper blepharoplasty.
[So] Source:J Plast Reconstr Aesthet Surg;70(3):375-379, 2017 Mar.
[Is] ISSN:1878-0539
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Upper blepharoplasties are a common procedure in plastic surgery. This procedure can be performed effectively under local anesthesia with or without sedation. The ideal local anesthetic should cause less intraoperative bleeding and less postoperative edema. Our study aimed to show the difference between the two local anesthetics 1% prilocaine (Xylonaest) in combination with epinephrine 1:100,000 and ropivacaine (Naropin) in combination with epinephrine 1:100,000 including sodium chloride, particularly in regard to swelling and bleeding in patients undergoing upper blepharoplasties. MATERIAL AND METHODS: In this double-blind, prospective, randomized study, 31 patients between March 2014 and September 2014 were included. The anesthetic agents used in all cases were 1% prilocaine (Xylonaest) in combination with epinephrine 1:100,000 for one side and ropivacaine consisting of 10-mg Naropin, 5-ml sodium chloride, and 1-ml epinephrine for the other side. The data presented in this study were collected by one of the surgeons performing the surgery. Intraoperative bleeding and postoperative edema were both calculated using a score of five points for each. RESULTS: The average bleeding tendency was 3.39 for prilocaine and 1.71 for local ropivacaine, showing a significant difference (p < 0.0001) between both local anesthetics in bleeding tendency. There was also a significant minor swelling at all times on the side on which ropivacaine was used. DISCUSSION: In our study, we demonstrated that ropivacaine (Naropin) has less intra- and postoperative side effects including swelling and bleeding compared with prilocaine (Xylonaest).
[Mh] Termos MeSH primário: Amidas
Anestésicos Locais
Blefaroplastia/métodos
Perda Sanguínea Cirúrgica/estatística & dados numéricos
Prilocaína
[Mh] Termos MeSH secundário: Anestésicos Combinados
Método Duplo-Cego
Edema/induzido quimicamente
Epinefrina
Feminino
Seres Humanos
Masculino
Complicações Pós-Operatórias/induzido quimicamente
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Amides); 0 (Anesthetics, Combined); 0 (Anesthetics, Local); 046O35D44R (Prilocaine); 7IO5LYA57N (ropivacaine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


  8 / 2063 MEDLINE  
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[PMID]:27823944
[Au] Autor:Abbas AM; Abdellah MS; Khalaf M; Bahloul M; Abdellah NH; Ali MK; Abdelmagied AM
[Ad] Endereço:Department of Obstetrics & Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt. Electronic address: bmr90@hotmail.com.
[Ti] Título:Effect of cervical lidocaine-prilocaine cream on pain perception during copper T380A intrauterine device insertion among parous women: A randomized double-blind controlled trial.
[So] Source:Contraception;95(3):251-256, 2017 Mar.
[Is] ISSN:1879-0518
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective was to investigate the analgesic effect of cervical lidocaine-prilocaine (LP) cream in alleviating pain during copper T380A intrauterine device (IUD) insertion among parous women. STUDY DESIGN: We conducted a randomized, double-blind, placebo-controlled trial at Assiut Women's Health Hospital, Egypt, from October 2015 to April 2016 of parous women desiring copper IUD insertion. We randomized the subjects in a 1:1 ratio to LP cream or placebo. Seven minutes prior to IUD insertion, women received 2 ml of LP cream or placebo to the anterior cervical lip, followed by 2 ml placed in the cervical canal using a Q-tip applicator. The study end point was the subjects' self-reported pain using a 10-cm visual analog scale (VAS) during cervical tenaculum placement, sound insertion, IUD insertion and 5 min postprocedure. We considered a 2-cm difference in VAS scores between study groups as clinically significant. Also, the difference in the ease of insertion score using a 10-cm VAS with 0=very easy insertion and 10=terribly difficult insertion was assessed. RESULTS: The study included 120 women (n=60 in each group). LP cream reduces the median VAS pain scores during tenaculum placement (2 vs. 4), sound insertion (3 vs. 6) and IUD insertion (3 vs. 6.5) with p=.0001 at all steps. A lower ease of insertion score was also determined among LP women (2.5±0.98 vs. 4.5±2.7, p=.001). Participants reported no side effects. CONCLUSIONS: Use of cervical LP cream prior to copper T380A IUD insertion may alleviate the IUD insertion pain among parous women. IMPLICATIONS: Cervical LP cream could be effective as an analgesic prior to copper T380A IUD insertion with no side effects. Further studies are needed to assess the women's satisfaction from lying with a speculum in place for 7 min while waiting for the cream to be effective.
[Mh] Termos MeSH primário: Anestésicos Combinados/administração & dosagem
Anestésicos Locais/administração & dosagem
Dispositivos Intrauterinos de Cobre/efeitos adversos
Lidocaína/administração & dosagem
Dor/tratamento farmacológico
Prilocaína/administração & dosagem
[Mh] Termos MeSH secundário: Administração Intravaginal
Adulto
Método Duplo-Cego
Egito
Feminino
Seres Humanos
Modelos Lineares
Análise Multivariada
Dor/etiologia
Medição da Dor
Percepção da Dor
Estudos Prospectivos
Fatores de Tempo
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Anesthetics, Local); 046O35D44R (Prilocaine); 98PI200987 (Lidocaine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


  9 / 2063 MEDLINE  
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[PMID]:27725350
[Au] Autor:Jeong DH; Yang JJ; Seok SH; Song DJ; Yeon SC
[Ad] Endereço:Species Restoration Technology Institute of Korea National Park Service, Gurye 542-853, Republic of Korea.
[Ti] Título:Cardiorespiratory effects of isoflurane in Asiatic black bears (Ursus thibetanus) anesthetized with intramuscular medetomidine and zolazepam/tiletamine.
[So] Source:J Vet Med Sci;79(1):153-159, 2017 Jan 20.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to determine the dose-dependent effects of isoflurane on various cardiovascular parameters and the stable range of isoflurane concentrations in Asiatic black bears (Ursus thibetanus). Seven Asiatic black bears were intramuscularly injected with medetomidine, zolazepam and tiletamine (MZT) to induce anesthesia, and anesthesia was maintained by administering isoflurane in 100% oxygen (4 l/min) without mechanical ventilation. Several cardiovascular parameters were measured at five end-tidal isoflurane concentrations (0.5, 1.0, 1.5, 2.0, and 2.5%). Blood was collected from the femoral artery before administration of isoflurane and after each administration for immediate blood gas analysis. Isoflurane produced dose-dependent increases in heart rate, respiratory rate, minute volume, end-tidal carbon dioxide (CO ) partial pressure and the partial pressure of arterial CO , and dose-dependent decreases in non-invasive blood pressure and tidal volume. Rectal temperature, oxygenation and acid-base balance were unaffected by isoflurane. All parameters in this study were in a clinically acceptable range at all times. The data show that the combination of MZT and isoflurane is suitable for general anesthesia in Asiatic black bears with spontaneous breathing during prolonged procedures. End-tidal isoflurane concentrations of 0.5 to 2.5% can be used in Asiatic black bears without adverse side effects.
[Mh] Termos MeSH primário: Anestesia Geral/veterinária
Anestésicos Combinados
Frequência Cardíaca
Isoflurano
Medetomidina
Respiração
Tiletamina
Ursidae
Zolazepam
[Mh] Termos MeSH secundário: Animais
Temperatura Corporal
Combinação de Medicamentos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Drug Combinations); 0 (tiletamine, zolazepam drug combination); 2YFC543249 (Tiletamine); CYS9AKD70P (Isoflurane); G1R474U58U (Zolazepam); MR15E85MQM (Medetomidine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.16-0290


  10 / 2063 MEDLINE  
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[PMID]:27401921
[Au] Autor:Khenissi L; Nikolayenkova-Topie O; Broussaud S; Touzot-Jourde G
[Ad] Endereço:1 Department of Anaesthesia, Langford Veterinary Services, University of Bristol, Langford, UK.
[Ti] Título:Comparison of intramuscular alfaxalone and ketamine combined with dexmedetomidine and butorphanol for castration in cats.
[So] Source:J Feline Med Surg;19(8):791-797, 2017 Aug.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives Cardiorespiratory parameters and anaesthesia quality in cats anaesthetised with either intramuscular (IM) alfaxalone or ketamine both combined with dexmedetomidine and butorphanol for castration were evaluated. Methods Thirty-two client-owned cats were randomly assigned to receive either alfaxalone (A; 3 mg/kg IM) or ketamine (K; 5 mg/kg IM), combined with dexmedetomidine (10 µg/kg) and butorphanol (0.2 mg/kg). Heart rate (HR), respiratory rate (RR) and rectal temperature (T°) were recorded prior to drug administration. Pulse rate (PR) and RR were recorded 10 (T ) and 15 (T ) mins after injection (T ). Cardiorespiratory values (PR, RR, SPO , blood pressure, P 'CO ) were recorded every 5 mins for the duration of the procedure. Pain at injection, intubation and recovery were evaluated with simple descriptive scores. Feasibility of anaesthesia was evaluated by the number of top-ups of anaesthetic needed. Cat attitude, ability to walk and presence of ataxia were assessed several times after extubation (T ) and the time between injection and extubation recorded. Pain was assessed at T and T with the 4Avet-pain score. Results The RR was significantly lower in group K at T (RR = 28 ±13.35 breaths per minute [brpm], RR = 43.24 ±7.04 brpm) and T (RR = 28 ±11.53 brpm vs RR = 43 ±12.18 brpm). Time to extubation was significantly longer in group A (T = 62 ±14.6 mins, T = 45.13 ± 7.38 mins). Cats in group K needed more top-ups, were more ataxic at T , had a worse recovery score at T and were less willing to walk at T . Conclusions and relevance Cats receiving alfaxalone had a longer but better quality recovery. Cardiorespiratory parameters were stable and within clinically acceptable values following IM injection of either alfaxalone or ketamine in healthy cats. Intramuscular alfaxalone is a suitable alternative to ketamine for short procedures requiring anaesthesia when used in combination with dexmedetomidine and butorphanol.
[Mh] Termos MeSH primário: Anestesia/veterinária
Anestésicos Combinados/administração & dosagem
Gatos/cirurgia
Dor Pós-Operatória/veterinária
[Mh] Termos MeSH secundário: Anestésicos Combinados/farmacologia
Animais
Pressão Sanguínea/efeitos dos fármacos
Butorfanol/administração & dosagem
Butorfanol/farmacologia
Gatos/fisiologia
Dexmedetomidina/administração & dosagem
Dexmedetomidina/farmacologia
Frequência Cardíaca/efeitos dos fármacos
Injeções Intramusculares/veterinária
Ketamina/administração & dosagem
Ketamina/farmacologia
Masculino
Orquiectomia/veterinária
Medição da Dor/veterinária
Dor Pós-Operatória/prevenção & controle
Pregnanodionas/administração & dosagem
Pregnanodionas/farmacologia
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Pregnanediones); 67VB76HONO (Dexmedetomidine); 690G0D6V8H (Ketamine); BD07M97B2A (alphaxalone); QV897JC36D (Butorphanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X16657951



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