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[PMID]:29191197
[Au] Autor:Tang X; Olatunji OJ; Zhou Y; Hou X
[Ad] Endereço:College of Horticulture, Nanjing Agricultural University, Weigang No.1, Nanjing, Jiangsu, 210095, China.
[Ti] Título:In vitro and in vivo aphrodisiac properties of the seed extract from Allium tuberosum on corpus cavernosum smooth muscle relaxation and sexual behavior parameters in male Wistar rats.
[So] Source:BMC Complement Altern Med;17(1):510, 2017 Dec 01.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allium tuberosum is a well-known spice as well as a herb in traditional Chinese medicine, used for increasing libido and treating erectile dysfunction. However, not many studies have been done to evaluate the sexual enhancing properties of A. tuberosum. The aim of this study was to evaluate the aphrodisiac and vasorelaxant properties of A. tuberosum on corpus cavernosum smooth muscle (CCSM) as well as checking the effect on enhancing male rat sexual behavior, libido, potency as well as its spermatogenic properties. METHOD: The seeds were powdered and sequentially extracted with hexane, ethyl acetate and butanol. Male Wistar rats were administered with graded doses of the n-BuOH extracts (ATB) of A. tuberosum (50, 100, 200 and 400 mg/kg) and Viagra was used as the positive control drug. The extract/drug was administered by gastric probe once daily for 45 days and the sexual behavior was analyzed by exposing the male rats to female rats in the estrus period. RESULTS: ATB relaxed corpus cavernosum smooth muscle (68.9%) at a concentration of 200 µg/ml. The results obtained from the animal studies indicated that ATB significantly increased mount frequency (MF), intromission frequency (IF), ejaculation frequency (EF), ejaculation latency (EL) and markedly reduced post ejaculatory interval (PEI), mount latency (ML), and intromission latency (IL). Furthermore, a remarkable increase in the test for potency was observed as witnessed by marked increase in erections, quick flips, long flips and total reflex. In addition, ATB significantly improved the sperm viability and count as well as increased the concentrations of testosterone, follicle stimulating hormone (FSH), and phosphatases in the treated animals. CONCLUSION: Thus our results suggest that A. tuberosum could stimulate sexual arousal and enhance sexual execution in male rats, thus providing valuable experimental evidence that A. tuberosum possesses sexual enhancing properties.
[Mh] Termos MeSH primário: Afrodisíacos/farmacologia
Cebolinha-Francesa/química
Relaxamento Muscular/efeitos dos fármacos
Extratos Vegetais/farmacologia
Comportamento Sexual/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Afrodisíacos/química
Feminino
Masculino
Músculo Liso/efeitos dos fármacos
Pênis/efeitos dos fármacos
Extratos Vegetais/química
Ratos
Ratos Wistar
Sementes/química
Citrato de Sildenafila/farmacologia
Espermatozoides/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Extracts); BW9B0ZE037 (Sildenafil Citrate)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2008-5


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[PMID]:28693591
[Au] Autor:Erhabor JO; Idu M
[Ad] Endereço:Permanent Address: Phytomedicine Unit, Department of Plant Biology and Biotechnology, University of Benin, PMB 1154, Benin, Nigeria. joseph.erhabor@uniben.edu.
[Ti] Título:Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats.
[So] Source:BMC Complement Altern Med;17(1):360, 2017 Jul 11.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aloe barbadensis (AB) is a short stemmed succulent medicinal herb that is being used by locals in Nigeria to enhance libido. Therefore this study evaluates the aphrodisiac potential and acute toxicological effect of A. barbadensis (AB) root in male Wistar rats. METHODS: Aphrodisiac potential was determined following the oral administration of graded doses (100, 200 and 400 mg/kg) of ethanol extract of A. barbadensis root. Sildenafil citrate (Viagra) and distilled water served as positive and negative controls respectively. Sexual behavioural parameters (mounting and intromission frequencies, mounting, intromission and ejaculatory latencies) were observed. Serum testosterone and cholesterol concentrations were also progressively monitored on days 1, 7 and 14. The acute toxicological evaluation of the plant were based on any onset behavioural changes and mortality respectively. RESULTS: The findings from the sexual behavioural study indicated that the ethanol extract of A. barbadensis significantly increased mounting frequency and intromission frequency but significantly decreased mount and intromission latencies in a dose dependent manner particularly on day 1 and 14. The ethanol extract also prolonged ejaculatory latency. The testosterone and cholesterol concentrations were also increased as the dose increased particularly on day 1 and 7. The lowest dose of 100 mg/kg showed the best aphrodisiac effect. The toxicity studies showed that there were no acute behavioural changes with zero mortality. CONCLUSION: The increased blood testosterone and cholesterol concentrations by the ethanol extract of A. barbadensis can probably be said to be the possible mechanisms of action for its aphrodisiac property. The plant may also be used to treat hypotestosteronemia following its ability to increase testosterone. These findings therefore give backing to the acclaimed local use of A. barbadensis root as an aphrodisiac in males.
[Mh] Termos MeSH primário: Aloe
Afrodisíacos/farmacologia
Ejaculação/efeitos dos fármacos
Libido/efeitos dos fármacos
Extratos Vegetais/farmacologia
Comportamento Sexual Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Colesterol/sangue
Masculino
Nigéria
Raízes de Plantas
Ratos Wistar
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Extracts); 3XMK78S47O (Testosterone); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1866-1


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[PMID]:28685547
[Au] Autor:Riaz M; Shahid M; Jamil A; Saqib M
[Ad] Endereço:Department of Biochemistry, University of Agriculture, Faisalabad-Pakistan.
[Ti] Título:In vitro antioxidant potential of selected aphrodisiac medicinal plants.
[So] Source:J Biol Regul Homeost Agents;31(2):419-424, 2017 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the antioxidant activity of six selected aphrodisiac medicinal plants. Useful parts of the selected medicinal plants were collected and extracted in methanolic solvent. The antioxidant activity of selected plant extract was determined through different antioxidant assays, namely DPPH radical scavenging assay and ferric reducing antioxidant assay. Moreover, antioxidant compounds, like total phenolics and total flavonoids contents, were also determined. Results showed that Mucuna pruriens seed extract displayed high contents of phenolic compounds with total phenolic content of 683.15±4.28 mg GAE/g dry plant material while the least phenolic content was observed in Asparagus racemosus (195.5±3.02 mg GAE/g dry plant material). Highest total flavonoids content was found in Anacyclus pyrethrum roots (156.58±4.01 µg CE/g) and the least content was found in Asparagus racemosus roots. Among the studied plant extracts, the highest radical scavenging activity was shown by Mucuna pruriens seed extract (82.05±0.55%) and the least percent scavenging activity was observed in Tribulus terrestris extract (36.40±2.01%). Vitamin C was used as positive control for antioxidant assays showing 93.54±0.9% radical scavenging activity. The plant extract also exhibited a strong reducing potential against free radicals. Therefore, the present study concluded that all the studied medicinal plants possess varying concentrations of secondary active metabolites responsible for the antioxidant properties of the tested plant extracts.
[Mh] Termos MeSH primário: Afrodisíacos/análise
Depuradores de Radicais Livres/análise
Extratos Vegetais/química
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Free Radical Scavengers); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28363129
[Au] Autor:Rahimi M; Shokri F; Hassanian-Moghaddam H; Zamani N; Pajoumand A; Shadnia S
[Ad] Endereço:Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Excellence Center of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Iranian Ministry of Health, Tehran, Ir
[Ti] Título:Severe camphor poisoning, a seven-year observational study.
[So] Source:Environ Toxicol Pharmacol;52:8-13, 2017 Jun.
[Is] ISSN:1872-7077
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In a retrospective case series from 2007 to 2014, we searched for any accidental/intentional, and recreational cases of pure camphor poisoning through hospital records. Epidemiological data, as well as factors correlated with seizure, were evaluated. Thirty cases including 29 males were recruited with a median age of 18 years (range; 0.2-87). Patient's reported ingestion rate of camphor was 1.5-15 grams. Almost all of the patients (96.7%) were conscious on arrival time and the ingestion to the presentation time ratio was 7±5h. It was observed that in a majority of the cases (53.4%), decreasing libido was the main intent of Camphor ingestion. Nausea and vomiting occurred in 22 (73.3%) cases and tonic-clonic seizure was seen in 12 (40%) patients. Mean presentation time was significantly longer in patients who experienced seizure (9.1±6.1h vs. 5.2±2.8h, p=0.05). No correlation was found between the amount of ingested camphor (grams or mg/kg) and vital signs along with the bio-chemistry results. Not only did all of our cases survive but also they exclusively received supportive care.
[Mh] Termos MeSH primário: Afrodisíacos/envenenamento
Cânfora/envenenamento
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Irã (Geográfico)/epidemiologia
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Aphrodisiacs); 76-22-2 (Camphor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


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[PMID]:28160849
[Au] Autor:Birri M; Vallejo M; Carro-Juárez M; Agnese AM
[Ad] Endereço:IMBIV, CONICET and Farmacognosia, Departamento de Farmacia, Fac. de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina.
[Ti] Título:Aphrodisiac activity of Phlegmariurus saururus in copulating and noncopulating male rats.
[So] Source:Phytomedicine;24:104-110, 2017 Jan 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Phlegmariurus saururus is popularly known in Argentina as aphrodisiac. For this reason, it was previously investigated and determined that the decoction of this plant elicits pro-ejaculatory activity and increases the ejaculatory potency in the Fictive Ejaculation Model. HYPOTHESIS/PURPOSE: the decoction of P. saururus facilitates sexual behavior in sexually experienced male rat and induces copulatory behavior in non-copulating male rats. METHODS: The extraction method (decoction) was validated through Selectivity, Accuracy and Precision, by identification of the majority alkaloids, expressed as sauroxine. Male (sexually experienced and noncopulating) and female (receptive) Wistar rats were used to determine sexual behavior. Sildenafil was used as positive control. The following variables were evaluated: Mount Latency, Intromission Latency, Ejaculation Latency, Post Ejaculatory Interval, as well as the Mounts and Intromissions Number. RESULTS: In sexually experienced male rats, P. saururus decoction stimulates sexual arousal and facilitates sexual execution. In noncopulating male rats, this decoction induces copulation with behavioral characteristics similar to sexually experienced animals. CONCLUSION: P. saururus possesses aphrodisiac activity in copulating and noncopulating male rats.
[Mh] Termos MeSH primário: Afrodisíacos/farmacologia
Huperzia/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
Comportamento Sexual Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Argentina
Feminino
Masculino
Fitoterapia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


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[PMID]:27312517
[Au] Autor:Abbas MA
[Ad] Endereço:Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
[Ti] Título:Is the use of plants in Jordanian folk medicine for the treatment of male sexual dysfunction scientifically based? Review of in vitro and in vivo human and animal studies.
[So] Source:Andrologia;49(3), 2017 Apr.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Male sexual dysfunction is a serious problem which has an impact on the quality of life. In Jordanian folk medicine, 56 plant species were reported to be used by males to improve sexual potency and as aphrodisiacs. The aim of this study was to search for scientific evidence justifying their folk use. Of the 15 studied plants, only five were found to enhance spermatogenesis. The other 10 were reported to decrease spermatogenesis at least by one study. The majority of the studied plants possessed a protective effect on testis in different in vivo models as well as antioxidant activities. The effect of these plants on steroidogenesis and the hypothalamic-gonadal axis was also reviewed. The effect of only five plants was studied on sexual behaviour enhancement and three of them were active. Three of the four studied plants enhanced erection. The mechanism of action of active constituents isolated from the studied plants was also investigated. In conclusion, many plants used in Jordanian folk medicine decreased or had no effect on spermatogenesis in animal models. These plants have antioxidant and/or adaptogenic effects, and this may result in a beneficial action on male reproductive system.
[Mh] Termos MeSH primário: Afrodisíacos/uso terapêutico
Disfunção Erétil/tratamento farmacológico
Medicina Arábica
Fitoterapia
Extratos Vegetais/uso terapêutico
Espermatogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antioxidantes/uso terapêutico
Medicina Baseada em Evidências
Seres Humanos
Jordânia
Masculino
Ereção Peniana/efeitos dos fármacos
Plantas Medicinais/química
Qualidade de Vida
Testículo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Aphrodisiacs); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE
[do] DOI:10.1111/and.12619


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[PMID]:27681645
[Au] Autor:Malviya N; Malviya S; Jain S; Vyas S
[Ad] Endereço:Smriti College of Pharmaceutical Education, Indore, India. nil30oct@gmail.com.
[Ti] Título:A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction.
[So] Source:Andrologia;48(8):880-93, 2016 Oct.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Male sexual dysfunction is a common disorder that appears to be a consequence of a wide range of physical and psychological conditions. Due to mental stress, insufficient physical exercise and various aetiological factors, human being's life is becoming less pleasant, which leads to incapability to have sexual pleasure. The allopathic drugs used for sexual dysfunction are believed to produce a variety of side effects and affect other physiological processes and, ultimately, general health. Therefore, the search for natural supplement from medicinal plants is being intensified probably because of less side effects availability and affordability. Ethnobotanical surveys have indicated a large number of plants traditionally used as aphrodisiacs but only few of them are scientifically validated for the management and treatment of male sexual dysfunction. This article has summarised the medicinal plants traditionally recommended and scientifically validated for the management and treatment of male sexual dysfunction.
[Mh] Termos MeSH primário: Afrodisíacos/uso terapêutico
Fitoterapia
Preparações de Plantas/uso terapêutico
Plantas Medicinais
Disfunções Sexuais Fisiológicas/tratamento farmacológico
Disfunções Sexuais Psicogênicas/tratamento farmacológico
[Mh] Termos MeSH secundário: Disfunção Erétil/tratamento farmacológico
Seres Humanos
Libido
Masculino
Ejaculação Precoce/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Preparations)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.1111/and.12677


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[PMID]:27681646
[Au] Autor:Lohiya NK; Balasubramanian K; Ansari AS
[Ad] Endereço:Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, India. lohiyank@gmail.com.
[Ti] Título:Indian folklore medicine in managing men's health and wellness.
[So] Source:Andrologia;48(8):894-907, 2016 Oct.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:India is a home for a large variety of plants with remarkable medicinal and pharmacological value. Traditional medicine in the form of Ayurveda, Siddha and Unani has used many of these plants since ancient days for treating and curing various ailments of the body. When it comes to issues related to reproductive health, people still hesitate to discuss and/or accept it openly and hence look for alternate and natural remedies. The various tribal populations distributed across different parts of the country still use these plant extracts in various formulations for maintenance of good health. The medical utilities of several of these plants have been documented; however, there are many more, whose potential is yet to be explored. This review discusses the role of various plants grown in the Indian subcontinent that have been widely used in maintaining various aspects of reproductive health in men such as infertility, aphrodisiac, contraception, libido, sexually transmitted infections and reproductive tract cancers as well as in treating chronic disorders.
[Mh] Termos MeSH primário: Afrodisíacos/uso terapêutico
Anticoncepção/métodos
Infertilidade Masculina/tratamento farmacológico
Medicina Ayurvédica
Fitoterapia
Preparações de Plantas/uso terapêutico
Neoplasias da Próstata/tratamento farmacológico
Doenças Sexualmente Transmissíveis/tratamento farmacológico
Neoplasias Testiculares/tratamento farmacológico
[Mh] Termos MeSH secundário: Seres Humanos
Índia
Masculino
Saúde do Homem
Saúde Reprodutiva
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Preparations)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.1111/and.12680


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[PMID]:27647010
[Au] Autor:Brusotti G; Papetti A; Serra M; Temporini C; Marini E; Orlandini S; Sanda AK; Watcho P; Kamtchouing P
[Ad] Endereço:Department of Drug Sciences, University of Pavia, Pavia, Italy; Center for Studies and Researches in Ethnobiopharmacy and Traditional and Complementary Medicines University of Pavia (CEMEC), Pavia, Italy. Electronic address: gloria.brusotti@unipv.it.
[Ti] Título:Allanblackia floribunda Oliv.: An aphrodisiac plant with vasorelaxant properties.
[So] Source:J Ethnopharmacol;192:480-485, 2016 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Allanblackia floribunda Oliv. is one of the most commonly used medicinal plant in Cameroon. The stem bark of the plant is traditionally used for its aphrodisiac and antihypertensive properties. AIM OF THE STUDY: To validate the traditional uses of Allanblackia floribunda stem bark ethanol extract through the evaluation of their aphrodisiac and vasorelaxant properties. MATERIALS AND METHODS: The extract's ability to increase sexual desire and the frequencies of erection (mount), intromission and prolonged latency of ejaculation were studied on adult male rats. The vasodilator effect was investigated using isolated rat aorta rings. Tests were conducted using fractions obtained by reverse phase column-chromatography (CC), after the acquisition of the HPLC fingerprint of the ethanol extract, resulted the most active in previous studies. RESULTS: The CC allowed the isolation of five fractions whose aphrodisiac and vasodilator activities were tested and compared with those of the whole extract. Four compounds were identified and characterized, three of them, Fukugiside, Morelloflavone and Volkensiflavone, are secondary metabolites known to be in Allanblackia floribunda; the fourth, Spicataside, is a biflavonoid glycoside known to be present in the genus Garcinia but never found neither in Allanblackia floribunda nor in Allanblackia genus. The crude ethanolic extract (CEE) induced a relaxation on aorta rings with EC =11±2µg/mL and Morelloflavone displayed a similar activity with EC =42±6µg/mL; for all the other compounds only the vasodilation % at the maximum concentration assessable (90µg/mL) was determined: 30±8 (Fukugiside), 24±6 (Spicataside), 33±4 (Morelloflavone+Volkensiflavone), 47±1 (Volkensiflavone). Regarding the activity on male sexual behaviour, only CEE and Fukugiside showed activity in the 9 parameters evaluated. CONCLUSIONS: These results may support the traditional uses of Allanblackia floribunda as aphrodisiac plant with antihypertensive properties suggesting the phytocomplex as responsible for the claimed activity.
[Mh] Termos MeSH primário: Aorta/efeitos dos fármacos
Afrodisíacos/farmacologia
Clusiaceae/química
Extratos Vegetais/farmacologia
Comportamento Sexual Animal/efeitos dos fármacos
Vasodilatação/efeitos dos fármacos
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Animais
Afrodisíacos/isolamento & purificação
Biflavonoides/isolamento & purificação
Biflavonoides/farmacologia
Cromatografia Líquida de Alta Pressão
Cromatografia de Fase Reversa
Relação Dose-Resposta a Droga
Ejaculação/efeitos dos fármacos
Etanol/química
Técnicas In Vitro
Masculino
Ereção Peniana/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Espectroscopia de Prótons por Ressonância Magnética
Ratos Wistar
Tempo de Reação
Solventes/química
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
Fatores de Tempo
Vasodilatadores/isolamento & purificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Biflavonoids); 0 (Plant Extracts); 0 (Solvents); 0 (Vasodilator Agents); 16851-21-1 (morelloflavone); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


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[PMID]:27561457
[Au] Autor:Sahin K; Orhan C; Akdemir F; Tuzcu M; Gencoglu H; Sahin N; Turk G; Yilmaz I; Ozercan IH; Juturu V
[Ad] Endereço:Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119, Elazig, Turkey. nsahinkm@yahoo.com.
[Ti] Título:Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats.
[So] Source:BMC Complement Altern Med;16(1):318, 2016 Aug 26.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mucuna pruriens, Tribulus terrestris and Ashwagandha (Withania somnifera) are widely known as antioxidant effective herbals and have been reported to possess aphrodisiac activities in traditional usages. In this study, we determined the effects of these herbals on sexual functions, serum biochemical parameters, oxidative stress and levels of NF-κB, Nrf2, and HO-1 in reproductive tissues. METHODS: Thirty-five male rats were divided into five groups: the control group, sildenafil-treated group (5 mg/kg/d), Mucuna, Tribulus and Ashwagandha groups. The extract groups were treated orally either with Mucuna, Tribulus or Ashwagandha (300 mg/kg b.w.) for 8 weeks. RESULTS: All of the extracts were found to be significantly effective in sexual functioning and antioxidant capacity and Tribulus showed the highest effectiveness. Serum testosterone levels significantly increased in Tribulus and Ashwagandha groups in comparison to control group. Tribulus was able to reduce the levels of NF-κB and increase the levels of Nrf2 and HO-1 to a much greater extent than Mucuna and Ashwagandha. CONCLUSIONS: These results demonstrate for the first time that Mucuna, Tribulus and Ashwagandha supplementation improves sexual function in male rats via activating Nrf2/ HO-1 pathway while inhibiting the NF-κB levels. Moreover, Tribulus terrestris extract was found to be more bioavailable from Ashwagandha extract followed by Mucuna extract. Schematic representation of the mode of action of some aphrodisiac herbal extracts to improve sexual functions.
[Mh] Termos MeSH primário: Afrodisíacos/farmacologia
Fator 2 Relacionado a NF-E2/metabolismo
NF-kappa B/metabolismo
Extratos Vegetais/farmacologia
Comportamento Sexual Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Afrodisíacos/química
Fertilidade/efeitos dos fármacos
Genitália Masculina/química
Genitália Masculina/efeitos dos fármacos
Masculino
Extratos Vegetais/química
Ratos
Transdução de Sinais/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Nfe2l2 protein, rat); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1303-x



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